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The purpose of this work was to evaluate the reactivation of cytomegalovirus (CMV) and Epstein–Barr virus (EBV) in immunocompetent patients in the intensive care unit (ICU) and to identify risk factors associated with reactivation. In this observational prospective study, 60 adult immunocompetent patients who stayed at least 7 days in an ICU were evaluated. During hospitalization, the viral load was monitored at admission and on day 7 with polymerase chain reaction to detect viral reactivation and weekly thereafter on days 14, 21, and 28 if hospitalization continued. The mean age of patients was 63.3 years (±23.4 years) and 34 (56.7 %) of them were male. Mean APACHE II scores for patients was 25 at admission. Of these patients, 28 were hospitalized in the internal ICU and 32 were hospitalized in the anesthesiology ICU. CMV/EBV reactivation was found in 17 individuals (12 for EBV, 3 for CMV, and 2 for both). The median high-sensitive C-reactive protein value in patients with CMV reactivation was significantly higher than in those patients without CMV reactivation (p = 0.037). EBV reactivation was statistically higher in patients with mechanical ventilation compared to patients without mechanical ventilation (p = 0.023). EBV reactivation in patients with fever was found to be statistically higher than in the patients without fever (p = 0.035). There is a need for extended studies with a larger number of patients from specific groups to better understand the reactivation frequency and identify risk factors. EBV and CMV reactivation should be taken into consideration in critically ill patients with fever, without specific symptoms and unresponsive to the treatment.

This paper describes primary subcutaneous infection caused by N. abscessus in a 60-year-old male patient with the history of non-Hodgkins lymphoma and chronic lymphocytic leukemia. The patient was presented with pain and swelling in his left thigh for 45 days. Soft tissue ultrasonography showed a heterogeneous and hypoechoic mass consistent with an abscess. Gram-positive and branched filamentous bacilli, along with neutrophils, were identified in gram-stained smears of the pus. Pus culture was positive for Gram-positive bacilli, which identified as N. abscessus. Initially, the patient was treated with trimethoprim-sulfamethoxazole. Due to insufficient clinical response, ceftriaxone was added for two weeks. Then, the patient was prescribed a 3-month course of trimethoprim-sulfamethoxazole. It is important to start appropriate and effective treatment as soon as possible in patients with immunosuppression. [Dis Mol Med 2016; 4(3.000): 31-33]

tp://dx.doi.org/10.1016/j.tmaid.20 77-8939/a 2015 Elsevier Ltd. All rig Dear sir, it is well known that Shigella spp. primarily cause gastrointestinal infections. Extra-intestinal manifestations are uncommon and mainly include neurological manifestations and arthritis [1]. Urinary tract infections (UTIs) due to Shigella spp. are rare, and Shigella sonnei UTIs are particularly unusual [2]. S. sonnei can be responsible for UTI during pregnancy even when no predisposing factors or an apparent source of infection can be identified [3]. In a study from USA, laboratory confirmed 208,368 Shigella isolates were examined and of these 71.7% were S. sonnei, 18.4% S. flexneri, 1.6% S. boydii, and 0.7% S. dysenteriae. Nearly all of these strains (99%) were recovered from stool and only 0.63% from urine [4]. This study also stressed that urine is the second most common source of positive isolates after feces. The contribution of fecal contamination should be noted for this rate. Unlike other studies, S. boydii was the most common isolated pathogen

Nekrotizan fasiit temelolarak fasya ve subkutan dokuları tutan, hızlı ilerleyen yıkıcı bir yumuşakdoku infeksiyonudur. Yüksek mortalite riski nedeni ile erken tanı ve tedavihayati önem taşımaktadır. Altmış altı yaşında kronik obstrüktif akciğerhastalığı olan erkek hasta ateş, sağ kalçada, ağrı-şişlik, sağ bacakta şişlik,yürümede güçlük, ağız kuruluğu ve halsizlik yakınmaları ile hastanemizebaşvurdu. Anamnezde intramüsküler steroid enjeksiyonu yaptırdığı öğrenildi.Fizik muayenede sağ gluteal bölgede, sağ uyluk ön ksımından popliteal fossayakadar yayılan hiperemik, ödemli ve dokunmakla ağrılı şişlik saptandı. Sepsisile komplike nekrotizan fasiit olarak değerlendirildi. Hastaya destek ve genişspektrumlu antibiyotik tedavisine ilave olarak cerrahi debritman, vakumdestekli kapama ve hiperbarik oksijen tedavisi uygulandı. Altı aylık tedavisüresi sonunda şifa ile taburcu edildi. Nekrotizan fasiit gelişimi açısındanriskli olduğu değerlendirilen hastalara intramüsküler enjeksiyon yapılırkendikkatli olunmalıdır. Nekrotizan fasiit gelişen olgularda erken tanı, uygunantibiyotik tedavisi ve erken geniş debritmana ilave hiperbarik oksijentedavisi sağ kalım oranlarını arttıracağı değerlendirilmektedir., Necrotising fasciitis is a devastating soft tissue infection which characterised by rapidly progressing necrosis involving mainly fascia and subcutaneous tissues. A 66-year old male patient with chronic obstructive pulmonary disease admitted to our hospital with fever, pain and swelling in the right thigh and right leg, difficulty in walking, dry mouth and weakness. There was a single dose intramuscular steroid injection story in his anamnesis. Physical examination revealed swelling, hyperemia and pain in the right gluteal region spreading through the right femur and popliteal fossa. He was diagnosed necrotizing fasciitis complicated with sepsis. We administered the supportive therapy and broad-spectrum antibiotic therapy in addition to the surgical debridement, vacuum assisted closure and hyperbaric oxygen therapy. The patient was discharged after six months of the follow-up period in hospital. In conclusion, Health-care personnel should be careful when the intramuscular injections planned for patients at the risk of development of necrotizing fasciitis reason of their chronic illnesses or immunosuppressive conditions. In patients who developed necrotizing fasciitis despite everything, we want to strongly emphasise the advantageous hyperbaric oxygen therapy as an additional therapy to the broad spe ctrum antibiotherapy and surgical debridement

Aim: The aim of this study is to explore the knowledge and motivations of voluntary blood donors toward allojeneic hematopoietic stem cell donation also, and to determine predictors of hematopoietic stem cell donation motivation among them. Material and methods: The knowledge and motivations of voluntary blood donors toward hematopoietic stem cell donation were evaluated using a questionnaire with 42 items. The sample consisted of 100 voluntary blood donors that admitted to Gulhane Military Medical Faculty Blood Training Center and Blood Bank Department, between May 1st and September 1st, 2015. Results: The mean age of participant was 33.5±6.8 and 83% of them was male. 91% of participant have never get information about hematopoietic stem cell donation and transplantation and 80% of them would like to get information. although 47% of participants keen on for donate ; they haven’t considered such concerns as the deterioration of bodily integrity (75.5%), a negative impact on their health (64.1%) and discomfort (37.7%) before. It was found to be willing for HSC donor both in routine blood donors and in higher education group (respectively values of p