Author: "Bullmore, Ed" / Publication Year Range: Last 10 years - Searchworks@Jio Institute Digital Library Search Results

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122 results on '"Bullmore, Ed"'

1. Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

Author: Wood, Greta K., Sargent, Brendan F., Ahmad, Zain-Ul-Abideen, Tharmaratnam, Kukatharmini, Dunai, Cordelia, Egbe, Franklyn N., Martin, Naomi H., Facer, Bethany, Pendered, Sophie L., Rogers, Henry C., Hübel, Christopher, van Wamelen, Daniel J., Bethlehem, Richard A. I., Giunchiglia, Valentina, Hellyer, Peter J., Trender, William, Kalsi, Gursharan, Needham, Edward, Easton, Ava, Jackson, Thomas A., Cunningham, Colm, Upthegrove, Rachel, Pollak, Thomas A., Hotopf, Matthew, Solomon, Tom, Pett, Sarah L., Shaw, Pamela J., Wood, Nicholas, Harrison, Neil A., Miller, Karla L., Jezzard, Peter, Williams, Guy, Duff, Eugene P., Williams, Steven, Zelaya, Fernando, Smith, Stephen M., Keller, Simon, Broome, Matthew, Kingston, Nathalie, Husain, Masud, Vincent, Angela, Bradley, John, Chinnery, Patrick, Menon, David K., Aggleton, John P., Nicholson, Timothy R., Taylor, John-Paul, David, Anthony S., Carson, Alan, Bullmore, Ed, Breen, Gerome, Hampshire, Adam, Michael, Benedict D., Paddick, Stella-Maria, and Leek, E. Charles
Published: 2024
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2. Neuroscience needs Network Science

Author: Barabási, Dániel L, Bianconi, Ginestra, Bullmore, Ed, Burgess, Mark, Chung, SueYeon, Eliassi-Rad, Tina, George, Dileep, Kovács, István A., Makse, Hernán, Papadimitriou, Christos, Nichols, Thomas E., Sporns, Olaf, Stachenfeld, Kim, Toroczkai, Zoltán, Towlson, Emma K., Zador, Anthony M, Zeng, Hongkui, Barabási, Albert-László, Bernard, Amy, and Buzsáki, György
Subjects: Quantitative Biology - Neurons and Cognition
Abstract: The brain is a complex system comprising a myriad of interacting elements, posing significant challenges in understanding its structure, function, and dynamics. Network science has emerged as a powerful tool for studying such intricate systems, offering a framework for integrating multiscale data and complexity. Here, we discuss the application of network science in the study of the brain, addressing topics such as network models and metrics, the connectome, and the role of dynamics in neural networks. We explore the challenges and opportunities in integrating multiple data streams for understanding the neural transitions from development to healthy function to disease, and discuss the potential for collaboration between network science and neuroscience communities. We underscore the importance of fostering interdisciplinary opportunities through funding initiatives, workshops, and conferences, as well as supporting students and postdoctoral fellows with interests in both disciplines. By uniting the network science and neuroscience communities, we can develop novel network-based methods tailored to neural circuits, paving the way towards a deeper understanding of the brain and its functions., Comment: 19 pages, 1 figure, 1 box
Published: 2023

3. Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.

Author: Lynall, Mary-Ellen, Soskic, Blagoje, Hayhurst, James, Schwartzentruber, Jeremy, Levey, Daniel, Pathak, Gita, Polimanti, Renato, Gelernter, Joel, Stein, Murray, Trynka, Gosia, Clatworthy, Menna, and Bullmore, Ed
Subjects: Catalytic Domain, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lymphocytes, Mental Disorders, Polymorphism, Single Nucleotide, Schizophrenia
Abstract: Multiple psychiatric disorders have been associated with abnormalities in both the innate and adaptive immune systems. The role of these abnormalities in pathogenesis, and whether they are driven by psychiatric risk variants, remains unclear. We test for enrichment of GWAS variants associated with multiple psychiatric disorders (cross-disorder or trans-diagnostic risk), or 5 specific disorders (cis-diagnostic risk), in regulatory elements in immune cells. We use three independent epigenetic datasets representing multiple organ systems and immune cell subsets. Trans-diagnostic and cis-diagnostic risk variants (for schizophrenia and depression) are enriched at epigenetically active sites in brain tissues and in lymphoid cells, especially stimulated CD4+ T cells. There is no evidence for enrichment of either trans-risk or cis-risk variants for schizophrenia or depression in myeloid cells. This suggests a possible model where environmental stimuli activate T cells to unmask the effects of psychiatric risk variants, contributing to the pathogenesis of mental health disorders.
Published: 2022

4. Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK

Author: Lone, Nazir, Baillie, Kenneth, Pairo-Castineira, Erola, Avramidis, Nikos, Wain, Louise, Guillen-Guio, Beatriz, Leavy, Olivia, Jones, S, Armstrong, Lisa, Hairsine, Brigid, Henson, Helen, Kurasz, Claire, Shaw, Alison, Shenton, Liz, Dobson, Hannah, Dell, Amanda, Fairbairn, Sara, Hawkings, Nancy, Haworth, Jill, Hoare, Michaela, Lewis, Victoria, Lucey, Alice, Mallison, Georgia, Nassa, Heeah, Pennington, Chris, Price, Andrea, Price, Claire, Storrie, Andrew, Willis, Gemma, Young, Susan, Poinasamy, Krisnah, Walker, Samantha, Jarrold, Ian, Rawlik, Konrad, Sanderson, Amy, Chong-James, K, David, C, James, W Y, Pfeffer, Paul, Zongo, O, Martineau, Adrian, Manisty, C, Armour, Cherie, Brown, Vanessa, Busby, John, Connolly, Bronwen, Craig, Thelma, Drain, Stephen, Heaney, Liam, King, Bernie, Magee, Nick, Major, E, McAulay, Danny, McGarvey, Lorcan, McGinness, Jade, Peto, Tunde, Stone, Roisin, Bolger, Annette, Davies, Ffyon, Haggar, Ahmed, Lewis, Joanne, Lloyd, Arwel, Manley, R, McIvor, Emma, Menzies, Daniel, Roberts, K, Saxon, W, Southern, David, Subbe, Christian, Whitehead, Victoria, Bularga, Anda, Mills, Nicholas, Dawson, Joy, El-Taweel, Hosni, Robinson, Leanne, Brear, Lucy, Regan, Karen, Saralaya, Dinesh, Storton, Kim, Amoils, Shannon, Bermperi, Areti, Cruz, Isabel, Dempsey, K, Elmer, Anne, Fuld, Jonathon, Jones, H, Jose, Sherly, Marciniak, Stefan, Parkes, M, Ribeiro, Carla, Taylor, Jessica, Toshner, Mark, Watson, L, Worsley, J, Broad, Lauren, Evans, Teriann, Haynes, Matthew, Jones, L, Knibbs, Lucy, McQueen, Alison, Oliver, Catherine, Paradowski, Kerry, Sabit, Ramsey, Williams, Jenny, Jones, Ian, Milligan, Lea, Harris, Edward, Sampson, Claire, Davies, Ellie, Evenden, Cerys, Hancock, Alyson, Hancock, Kia, Lynch, Ceri, Rees, Meryl, Roche, Lisa, Stroud, Natalie, Thomas-Woods, T, Heller, Simon, Chalder, Trudie, Shah, Kamini, Robertson, Elizabeth, Young, Bob, Babores, Marta, Holland, Maureen, Keenan, Natalie, Shashaa, Sharlene, Wassall, Helen, Austin, Liam, Beranova, Eva, Cosier, Tracey, Deery, Joanne, Hazelton, Tracy, Price, Carly, Ramos, Hazel, Solly, Reanne, Turney, Sharon, Weston, Heather, Coughlan, Eamon, Ralser, Markus, Pearce, Lorraine, Pugmire, S, Stoker, Wendy, Wilson, Ann, McCormick, W, Fraile, Eva, Ugoji, Jacinta, Aguilar Jimenez, Laura, Arbane, Gill, Betts, Sarah, Bisnauthsing, Karen, Dewar, A, Hart, Nicholas, Kaltsakas, G, Kerslake, Helen, Magtoto, Murphy, Marino, Philip, Martinez, L M, Ostermann, Marlies, Rossdale, Jennifer, Solano, Teresa, Alvarez Corral, Maria, Arias, Ava Maria, Bevan, Emily, Griffin, Denise, Martin, Jane, Owen, J, Payne, Sheila, Prabhu, A, Reed, Annabel, Storrar, Will, Williams, Nick, Wrey Brown, Caroline, Burdett, Tracy, Featherstone, James, Lawson, Cathy, Layton, Alison, Mills, Clare, Stephenson, Lorraine, Ellis, Yvette, Atkin, Paul, Brindle, K, Crooks, Michael, Drury, Katie, Easom, Nicholas, Flockton, Rachel, Holdsworth, L, Richards, A, Sykes, D L, Thackray-Nocera, Susannah, Wright, C, Coetzee, S, Davies, Kim, Hughes, Rachel Ann, Loosley, Ronda, McGuinness, Heather, Mohamed, Abdelrahman, O'Brien, Linda, Omar, Zohra, Perkins, Emma, Phipps, Janet, Ross, Gavin, Taylor, Abigail, Tench, Helen, Wolf-Roberts, Rebecca, Burden, L, Calvelo, Ellen, Card, Bethany, Carr, Caitlin, Chilvers, Edwin, Copeland, Donna, Cullinan, P, Daly, Patrick, Evison, Lynsey, Fayzan, Tamanah, Gordon, Hussain, Haq, Sulaimaan, Jenkins, Gisli, King, Clara, Kon, Onn Min, March, Katherine, Mariveles, Myril, McLeavey, Laura, Mohamed, Noura, Moriera, Silvia, Munawar, Unber, Nunag, Jose Lloyd, Nwanguma, Uchechi, Orriss-Dib, Lorna, Ross, Alexandra, Roy, Maura, Russell, Emily, Samuel, Katherine, Schronce, J, Simpson, Neil, Tarusan, Lawrence, Thomas, David, Wood, Chloe, Yasmin, Najira, Altmann, Danny, Howard, Luke, Johnston, Desmond, Lingford-Hughes, Anne, Man, William, Mitchell, Jane, Molyneaux, Philip, Nicolaou, Christos, O'Regan, D P, Price, L, Quint, Jenni, Smith, David, Thwaites, Ryan, Valabhji, Jonathon, Walsh, Simon, Efstathiou, Claudia, Liew, Felicity, Frankel, Anew, Lightstone, Liz, McAdoo, Steve, Wilkins, Martin, Willicombe, Michelle, Touyz, R, Guerdette, Anne-Marie, Hewitt, Melanie, Reddy, R, Warwick, Katie, White, Sonia, McMahon, Aisling, Adeyemi, Oluwaseun, Adrego, Rita, Assefa-Kebede, Hosanna, Breeze, Jonathon, Byrne, S, Dulawan, Pearl, Hoare, Amy, Jolley, Caroline, Knighton, Abigail, Patale, Sheetal, Peralta, Ida, Powell, Natassia, Ramos, Albert, Shevket, K, Speranza, Fabio, Te, Amelie, Malim, M, Bramham, Kate, Brown, M, Ismail, Khalida, Nicholson, Tim, Pariante, Carmen, Sharpe, Claire, Wessely, Simon, Whitney, J, Shah, Ajay, Chiribiri, A, O'Brien, C, Hayday, A, Ashworth, Andrew, Beirne, Paul, Clarke, Jude, Coupland, C, Dalton, Matthhew, Favager, Clair, Glossop, Jodie, Greenwood, John, Hall, Lucy, Hardy, Tim, Humphries, Amy, Murira, Jennifer, Peckham, Dan, Plein, S, Rangeley, Jade, Saalmink, Gwen, Tan, Ai Lyn, Wade, Elaine, Whittam, Beverley, Window, Nicola, Woods, Janet, Coakley, G, Turtle, Lance, Allerton, Lisa, Allt, Ann Marie, Beadsworth, M, Berridge, Anthony, Brown, Jo, Cooper, Shirley, Cross, Andy, Defres, Sylviane, Dobson, S L, Earley, Joanne, French, N, Greenhalf, William, Hainey, Kera, Hardwick, Hayley, Hawkes, Jenny, Highett, Victoria, Kaprowska, Sabina, Key, Angela, Lavelle-Langham, Lara, Lewis-Burke, N, Madzamba, Gladys, Malein, Flora, Marsh, Sophie, Mears, Chloe, Melling, Lucy, Noonan, Matthew, Poll, L, Pratt, James, Richardson, Emma, Rowe, Anna, Semple, Calum, Shaw, Victoria, Tripp, K A, Wajero, Lilian, Williams-Howard, S A, Wootton, Dan, Wyles, J, Diwanji, Shalin, Gurram, Sambasivarao, Papineni, Padmasayee, Quaid, Sheena, Tiongson, Gerlynn, Watson, Ekaterina, Briggs, Andrew, Marks, Michael, Hastie, Claire, Rogers, Natalie, Smith, Nikki, Stensel, David, Bishop, Lettie, McIvor, Katherine, Rivera-Ortega, Pilar, Al-Sheklly, Bashar, Avram, Cristina, Blaikely, John, Buch, M, Choudhury, N, Faluyi, David, Felton, T, Gorsuch, T, Hanley, Neil, Horsley, Alex, Hussell, Tracy, Kausar, Zunaira, Odell, Natasha, Osbourne, Rebecca, Piper Hanley, Karen, Radhakrishnan, K, Stockdale, Sue, Kabir, Thomas, Scott, Janet, Stewart, Iain, Openshaw, Peter, Burn, David, Ayoub, A, Brown, J, Burns, G, Davies, Gareth, De Soyza, Anthony, Echevarria, Carlos, Fisher, Helen, Francis, C, Greenhalgh, Alan, Hogarth, Philip, Hughes, Joan, Jiwa, Kasim, Jones, G, MacGowan, G, Price, D, Sayer, Avan, Simpson, John, Tedd, H, Thomas, S, West, Sophie, Witham, M, Wright, S, Young, A, McMahon, Michael, Neill, Paula, Anderson, David, Basu, Neil, Bayes, Hannah, Brown, Ammani, Dougherty, Andrew, Fallon, K, Gilmour, L, Grieve, D, Mangion, K, Morrow, A, Sykes, R, Berry, Colin, McInnes, I B, Scott, Kathryn, Barrett, Fiona, Donaldson, A, Sage, Beth, Bell, Murdina, Brown, Angela, Hamil, R, Leitch, Karen, Macliver, L, Patel, Manish, Quigley, Jackie, Smith, Andrew, Welsh, B, Choudhury, Gaunab, Clohisey, S, Deans, Andrew, Docherty, Annemarie, Furniss, J, Harrison, Ewen, Kelly, S, Sheikh, Aziz, Chalmers, James, Connell, David, Deas, C, Elliott, Anne, George, J, Mohammed, S, Rowland, J, Solstice, AR, Sutherland, Debbie, Tee, Caroline, Bunker, Jenny, Gill, Rhyan, Nathu, Rashmita, Holmes, Katie, Adamali, H, Arnold, David, Barratt, Shaney, Dipper, A, Dunn, Sarah, Maskell, Nick, Morley, Anna, Morrison, Leigh, Stadon, Louise, Waterson, Samuel, Welch, H, Jayaraman, Bhagy, Light, Tessa, Vogiatzis, Ioannis, Almeida, Paula, Bolton, Charlotte, Hosseini, Akram, Matthews, Laura, Needham, Robert, Shaw, Karen, Thomas, Andrew, Bonnington, J, Chrystal, Melanie, Dupont, Catherine, Greenhaff, Paul, Gupta, Ayushman, Jang, W, Linford, S, Nikolaidis, Athanasios, Prosper, Sabrina, Burns, A, Kanellakis, N, Ferreira, V, Nikolaidou, C, Xie, C, Ainsworth, Mark, Alamoudi, Asma, Bloss, Angela, Carter, Penny, Cassar, M, Chen, Jin, Conneh, Florence, Dong, T, Evans, Ranuromanana, Fraser, Emily, Geddes, John, Gleeson, F, Harrison, Paul, Havinden-Williams, May, Ho, Ling Pei, Jezzard, P, Koychev, Ivan, Kurupati, Prathiba, McShane, H, Megson, Clare, Neubauer, Stefan, Nicoll, Debby, Ogg, G, Pacpaco, Edmund, Pavlides, M, Peng, Yanchun, Petousi, Nayia, Pimm, John, Rahman, Najib, Raman, Betty, Rowland, M J, Saunders, Kathryn, Sharpe, Michael, Talbot, Nick, Tunnicliffe, E M, Korszun, Ania, Kerr, Steven, Barker, R E, Cristiano, Daniele, Dormand, N, George, P, Gummadi, Mahitha, Kon, S, Liyanage, Kamal, Nolan, C M, Patel, B, Patel, Suhani, Polgar, Oliver, Shah, P, Singh, Suver, Walsh, J A, Gibbons, Michael, Ahmad, Shanaz, Brill, Simon, Hurst, John, Jarvis, Hannah, Lim, Lai, Mandal, S, Matila, Darwin, Olaosebikan, Olaoluwa, Singh, Claire, Laing, C, Baxendale, Helen, Garner, Lucie, Johnson, C, Mackie, J, Michael, Alice, Newman, J, Pack, Jamie, Paques, K, Parfrey, H, Parmar, J, Reddy, A, Halling-Brown, Mark, Dark, P, Diar-Bakerly, Nawar, Evans, D, Hardy, E, Harvey, Alice, Holgate, D, Knight, Sean, Mairs, N, Majeed, N, McMorrow, L, Oxton, J, Pendlebury, Jessica, Summersgill, C, Ugwuoke, R, Whittaker, S, Matimba-Mupaya, Wadzanai, Strong-Sheldrake, Sophia, Chowienczyk, Phillip, Bagshaw, J, Begum, M, Birchall, K, Butcher, Robyn, Carborn, H, Chan, Flora, Chapman, Kerry, Cheng, Yutung, Chetham, Luke, Clark, Cameron, Coburn, Zach, Cole, Joby, Dixon, Myles, Fairman, Alexandra, Finnigan, J, Foot, H, Foote, David, Ford, Amber, Gregory, Rebecca, Harrington, Kate, Haslam, L, Hesselden, L, Hockridge, J, Holbourn, Ailsa, Holroyd-Hind, B, Holt, L, Howell, Alice, Hurditch, E, Ilyas, F, Jarman, Claire, Lawrie, Allan, Lee, Ju Hee, Lee, Elvina, Lenagh, Rebecca, Lye, Alison, Macharia, Irene, Marshall, M, Mbuyisa, Angeline, McNeill, J, Megson, Sharon, Meiring, J, Milner, L, Misra, S, Newell, Helen, Newman, Tom, Norman, C, Nwafor, Lorenza, Pattenadk, Dibya, Plowright, Megan, Porter, Julie, Ravencroft, Phillip, Roddis, C, Rodger, J, Rowland-Jones, Sarah, Saunders, Peter, Sidebottom, J, Smith, Jacqui, Smith, Laurie, Steele, N, Stephens, G, Stimpson, R, Thamu, B, Thompson, A. A. Roger, Tinker, N, Turner, Kim, Turton, Helena, Wade, Phillip, Walker, S, Watson, James, Wilson, Imogen, Zawia, Amira, Allsop, Lynne, Bennett, Kaytie, Buckley, Phil, Flynn, Margaret, Gill, Mandy, Goodwin, Camelia, Greatorex, M, Gregory, Heidi, Heeley, Cheryl, Holloway, Leah, Holmes, Megan, Hutchinson, John, Kirk, Jill, Lovegrove, Wayne, Sewell, Terri Ann, Shelton, Sarah, Sissons, D, Slack, Katie, Smith, Susan, Sowter, D, Turner, Sarah, Whitworth, V, Wynter, Inez, Tomlinson, Johanne, Warburton, Louise, Painter, Sharon, Palmer, Sue, Redwood, Dawn, Tilley, Jo, Vickers, Carinna, Wainwright, Tania, Breen, G, Hotopf, M, Aul, Raminder, Forton, D, Ali, Mariam, Dunleavy, A, Mencias, Mark, Msimanga, N, Samakomva, T, Siddique, Sulman, Tavoukjian, Vera, Teixeira, J, Ahmed, Rubina, Francis, Richard, Connor, Lynda, Cook, Amanda, Davies, Gwyneth, Rees, Tabitha, Thaivalappil, Favas, Thomas, Caradog, McNarry, M, Williams, N, Lewis, Keir, Coulding, Martina, Jones, Heather, Kilroy, Susan, McCormick, Jacqueline, McIntosh, Jerome, Turner, Victoria, Vere, Joanne, Butt, Al-Tahoor, Savill, Heather, Kon, Samantha, Landers, G, Lota, Harpreet, Portukhay, Sofiya, Nasseri, Mariam, Daniels, Alison, Hormis, Anil, Ingham, Julie, Zeidan, Lisa, Chablani, Manish, Osborne, Lynn, Aslani, Shahab, Banerjee, Amita, Batterham, R, Baxter, Gabrielle, Bell, Robert, David, Anthony, Denneny, Emma, Hughes, Alun, Lilaonitkul, W, Mehta, P, Pakzad, Ashkan, Rangelov, Bojidar, Williams, B, Willoughby, James, Xu, Moucheng, Ahwireng, Nyarko, Bang, Dongchun, Basire, Donna, Brown, Jeremy, Chambers, Rachel, Checkley, A, Evans, R, Heightman, M, Hillman, T, Jacob, Joseph, Jastrub, Roman, Lipman, M, Logan, S, Lomas, D, Merida Morillas, Marta, Plant, Hannah, Porter, Joanna, Roy, K, Wall, E, Treibel, T, Ahmad Haider, N, Atkin, Catherine, Baggott, Rhiannon, Bates, Michelle, Botkai, A, Casey, Anna, Cooper, B, Dasgin, Joanne, Dawson, Camilla, Draxlbauer, Katharine, Gautam, N, Hazeldine, J, Hiwot, T, Holden, Sophie, Isaacs, Karen, Jackson, T, Kamwa, Vicky, Lewis, D, Lord, Janet, Madathil, S, McGee, C, Mcgee, K, Neal, Aoife, Newton-Cox, Alex, Nyaboko, Joseph, Parekh, Dhruv, Peterkin, Z, Qureshi, H, Ratcliffe, Liz, Sapey, Elizabeth, Short, J, Soulsby, Tracy, Stockley, J, Suleiman, Zehra, Thompson, Tamika, Ventura, Maximina, Walder, Sinead, Welch, Carly, Wilson, Daisy, Yasmin, S, Yip, Kay Por, Chaudhuri, N, Childs, Caroline, Djukanovic, R, Fletcher, S, Harvey, Matt, Jones, Mark, Marouzet, Elizabeth, Marshall, B, Samuel, Reena, Sass, T, Wallis, Tim, Wheeler, Helen, Steeds, R, Beckett, Paul, Dickens, Caroline, Nanda, Uttam, Aljaroof, M, Armstrong, Natalie, Arnold, H, Aung, Hnin, Bakali, Majda, Bakau, M, Baldry, E, Baldwin, Molly, Bourne, Charlotte, Bourne, Michelle, Brightling, Chris, Brunskill, Nigel, Cairns, P, Carr, Liesel, Charalambou, Amanda, Christie, C, Davies, Melanie, Daynes, Enya, Diver, Sarah, Dowling, Rachael, Edwards, Sarah, Edwardson, C, Elneima, Omer, Evans, H, Evans, Rachael, Finch, J, Glover, Sarah, Goodman, Nicola, Gooptu, Bibek, Greening, Neil, Hadley, Kate, Haldar, Pranab, Hargadon, Beverley, Harris, Victoria, Houchen-Wolloff, Linzy, Ibrahim, W, Ingram, L, Khunti, Kamlesh, Lea, A, Lee, D, McAuley, Hamish, McCann, Gerry, McCourt, P, Mcnally, Teresa, Mills, George, Monteiro, Will, Pareek, Manish, Parker, S, Prickett, Anne, Qureshi, I N, Rowland, A, Russell, Richard, Sereno, Marco, Shikotra, Aarti, Siddiqui, Salman, Singapuri, Ananga, Singh, Sally, Skeemer, J, Soares, M, Stringer, E, Thornton, T, Tobin, Martin, Ward, T J C, Woodhead, F, Yates, Tom, Yousuf, A J, Broome, Mattew, McArdle, Paul, Thickett, David, Upthegrove, Rachel, Wilkinson, Dan, Moss, Paul, Wraith, David, Evans, Jonathon, Bullmore, Ed, Heeney, Jonathon, Langenberg, Claudia, Schwaeble, William, Summers, Charlotte, Weir McCall, J, Adeloye, Davies, Newby, D E, Pius, Riinu, Rudan, Igor, Shankar-Hari, Manu, Sudlow, Catherine, Thorpe, Mat, Walmsley, Sarah, Zheng, Bang, Allan, Louise, Ballard, Clive, McGovern, Andrew, Dennis, J, Cavanagh, Jonathon, MacDonald, S, O'Donnell, Kate, Petrie, John, Sattar, Naveed, Spears, Mark, Guthrie, Elspeth, Henderson, Max, Allen, Richard, Bingham, Michelle, Brugha, Terry, Finney, Selina, Free, Rob, Jones, Don, Lawson, Claire, Lucy, Gardiner, Moss, Alistair, Mukaetova-Ladinska, Elizabeta, Novotny, Petr, Overton, Charlotte, Pearl, John, Plekhanova, Tatiana, Richardson, M, Samani, Nilesh, Sargant, Jack, Sharma, M, Steiner, Mike, Taylor, Chris, Terry, Sarah, Tong, C, Turner, E, Wormleighton, J, Zhao, Bang, Ntotsis, Kimon, Saunders, Ruth, Lozano-Rojas, Daniel, Goemans, Anne, Cuthbertson, D, Kemp, G, McArdle, Anne, Michael, Benedict, Reynolds, Will, Spencer, Lisa, Vinson, Ben, Ashworth, M, Abel, Kathryn, Chinoy, H, Deakin, Bill, Harvie, M, Miller, C A, Stanel, Stefan, Barran, Perdita, Trivedi, Drupad, McAllister-Williams, Hamish, Paddick, Stella-Maria, Rostron, Anthony, Taylor, John Paul, Baguley, David, Coleman, Chris, Cox, E, Fabbri, Laura, Francis, Susan, Hall, Ian, Hufton, E, Johnson, Simon, Khan, Fasih, Kitterick, Paaig, Morriss, Richard, Selby, Nick, Wright, Louise, Antoniades, Charalambos, Bates, A, Beggs, M, Bhui, Kamaldeep, Breeze, Katie, Channon, K M, Clark, David, Fu, X, Husain, Masud, Li, X, Lukaschuk, E, McCracken, Celeste, McGlynn, K, Menke, R, Motohashi, K, Nichols, T E, Ogbole, Godwin, Piechnik, S, Propescu, I, Propescu, J, Samat, A A, Sanders, Z B, Sigfrid, Louise, Webster, M, Kingham, Lucy, Klenerman, Paul, Lamlum, Hanan, Taquet, Maxime, Carson, G, Finnigan, L, Saunders, Laura, Wild, James, Calder, P C, Huneke, Nathan, Simons, Gemma, Baldwin, David, Bain, Steve, Daines, Luke, Bright, E, Crisp, P, Dharmagunawardena, Ruvini, Stern, M, Bailey, Elisabeth, Reddington, Anne, Wight, Andrew, Ashish, A, Cooper, Josh, Robinson, Emma, Broadley, Andrew, Barman, Laura, Brookes, Claire, Elliott, K, Griffiths, L, Guy, Zoe, Howard, Kate, Ionita, Diana, Redfearn, Heidi, Sarginson, Carol, Turnbull, Alison, Skorniewska, Zuzanna, De Deyn, Thomas, Hampshire, Adam, Trender, William R, Hellyer, Peter J, Chalmers, James D, Ho, Ling-Pei, Leavy, Olivia C, Richardson, Matthew, McAuley, Hamish J C, Singapuri, Amisha, Saunders, Ruth M, Harris, Victoria C, Greening, Neil J, Mansoori, Parisa, Harrison, Ewen M, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Brightling, Christopher E, Wain, Louise V, Evans, Rachael A, Geddes, John R, and Harrison, Paul J
Published: 2024
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5. Multidisciplinary research priorities for the COVID-19 pandemic – Authors' reply

Author: O'Connor, Rory C, Hotopf, Matthew, Worthman, Carol M, Perry, V Hugh, Tracey, Irene, Wessely, Simon, Arseneault, Louise, Ballard, Clive, Christensen, Helen, Silver, Roxane Cohen, Ford, Tamsin, John, Ann, Kabir, Thomas, King, Kate, Simpson, Alan, Madan, Ira, Cowan, Katherine, Bullmore, Ed, and Holmes, Emily A
Subjects: Betacoronavirus, COVID-19, Coronavirus Infections, Humans, Interdisciplinary Research, Mental Health, Pandemics, Pneumonia, Viral, SARS-CoV-2, Clinical Sciences, Public Health and Health Services, Psychology
Published: 2020

6. Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science

Author: Holmes, Emily A, O'Connor, Rory C, Perry, V Hugh, Tracey, Irene, Wessely, Simon, Arseneault, Louise, Ballard, Clive, Christensen, Helen, Cohen Silver, Roxane, Everall, Ian, Ford, Tamsin, John, Ann, Kabir, Thomas, King, Kate, Madan, Ira, Michie, Susan, Przybylski, Andrew K, Shafran, Roz, Sweeney, Angela, Worthman, Carol M, Yardley, Lucy, Cowan, Katherine, Cope, Claire, Hotopf, Matthew, and Bullmore, Ed
Subjects: Behavioral and Social Science, Mental Health, Mental health, Good Health and Well Being, COVID-19, Coronavirus Infections, Humans, Mental Disorders, Pandemics, Pneumonia, Viral, Research, Clinical Sciences, Public Health and Health Services, Psychology
Abstract: The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research. These priorities were informed by surveys of the public and an expert panel convened by the UK Academy of Medical Sciences and the mental health research charity, MQ: Transforming Mental Health, in the first weeks of the pandemic in the UK in March, 2020. We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time. The need to maintain high-quality research standards is imperative. International collaboration and a global perspective will be beneficial. An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19. There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19. Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required. Rising to this challenge will require integration across disciplines and sectors, and should be done together with people with lived experience. New funding will be required to meet these priorities, and it can be efficiently leveraged by the UK's world-leading infrastructure. This Position Paper provides a strategy that may be both adapted for, and integrated with, research efforts in other countries.
Published: 2020

7. Prefrontal connectomics: from anatomy to human imaging

Author: Haber, Suzanne N., Liu, Hesheng, Seidlitz, Jakob, and Bullmore, Ed
Published: 2022
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8. 29. Post-Natal Development of the Rat Connectome and the Impacts of Early Life and Adult Stress

Author: Smith, Rachel, primary, Dorfschmidt, Lena, additional, Sawiak, Stephen J., additional, Dutcher, Ethan, additional, McMahon, Francis J., additional, Raznahan, Armin, additional, Dalley, Jeffrey W., additional, Vértes, Petra, additional, and Bullmore, Ed, additional
Published: 2024
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9. A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Author: Wlazly, Dominika, Dickinson, Amber, Foster, Andy, Knight, Clare, Leckey, Claire, Morgan, Paul, Morgan, Angharad, O'Hagan, Caroline, Touchard, Samuel, Khan, Shahid, Murphy, Phil, Parker, Christine, Patel, Jai, Richardson, Jill, Acton, Paul, Austin, Nigel, Bhattacharya, Anindya, Carruthers, Nick, de Boer, Peter, Drevets, Wayne, Isaac, John, Jones, Declan, Kemp, John, Kolb, Hartmuth, Nye, Jeff, Wittenberg, Gayle, Barker, Gareth, Bogdanova, Anna, Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Enache, Daniela, Gee, Tony, Hastings, Caitlin, Kose, Melisa, Lombardo, Giulia, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Pariante, Carmine, Randall, Karen, Schubert, Julia, Sforzini, Luca, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Turkheimer, Federico, Van Loo, Vicky, Veronese, Mattia, Rodriguez, Marta Vicente, Wood, Toby, Worrell, Courtney, Zajkowska, Zuzanna, Campbell, Brian, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Moeller, Thomas, Nelson, Bob, Plath, Niels, Thomsen, Christian, Pederson, Jan Torleif, Zorn, Stevin, Deith, Catherine, Farmer, Scott, McClean, John, McPherson, Andrew, Penandes, Nagore, Scouller, Paul, Sutherland, Murray, Attenburrow, Mary Jane, Benjamin, Jithen, Jones, Helen, Mada, Fran, Oladejo, Akintayo, Smith, Katy, Balice-Gordon, Rita, Binneman, Brendon, Duerr, James, Fullerton, Terence, Goli, Veeru, Hughes, Zoe, Piro, Justin, Samad, Tarek, Sporn, Jonathan, Hoskins, Liz, Kohn, Charmaine, Wilcock, Lauren, Aigbirhio, Franklin, Bhatti, Junaid, Bullmore, Ed, Chamberlain, Sam, Correia, Marta, Crofts, Anna, Fryer, Tim, Graves, Martin, Hatton, Alex, Kitzbichler, Manfred, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy, Cavanagh, Jonathan, McColl, Alison, Shaw, Robin, Boddeke, Erik, Baird, Alison, Clare, Stuart, Cowen, Phil, Huang, I-Shu (Dante), Hurley, Sam, Lovestone, Simon, Nevado-Holgado, Alejo, Ribe, Elena, Vyas, Anviti, Winchester, Laura, Cleal, Madeleine, Gomez-Nicola, Diego, Mancuso, Renzo, Perry, Hugh, Cercignani, Mara, Clarke, Charlotte, Colasanti, Alessandro, Harrison, Neil, Murray, Rosemary, O'Connor, Jason, Mount, Howard, Schubert, Julia J., Fryer, Tim D., Manavaki, Roido, Kitzbichler, Manfred G., Nettis, Maria A., Pariante, Carmine M., Bullmore, Edward T., and Turkheimer, Federico E.
Published: 2021
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10. Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK

Author: Taquet, Maxime, Skorniewska, Zuzanna, De Deyn, Thomas, Hampshire, Adam, Trender, William R, Hellyer, Peter J, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Raman, Betty, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish J C, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M, Harris, Victoria C, Rogers, Natalie, Houchen-Wolloff, Linzy, Greening, Neil J, Mansoori, Parisa, Harrison, Ewen M, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Brightling, Christopher E, Wain, Louise V, Evans, Rachael A, Geddes, John R, Harrison, Paul J, Lone, Nazir, Baillie, Kenneth, Pairo-Castineira, Erola, Avramidis, Nikos, Wain, Louise, Guillen-Guio, Beatriz, Leavy, Olivia, Jones, S, Armstrong, Lisa, Hairsine, Brigid, Henson, Helen, Kurasz, Claire, Shaw, Alison, Shenton, Liz, Dobson, Hannah, Dell, Amanda, Fairbairn, Sara, Hawkings, Nancy, Haworth, Jill, Hoare, Michaela, Lewis, Victoria, Lucey, Alice, Mallison, Georgia, Nassa, Heeah, Pennington, Chris, Price, Andrea, Price, Claire, Storrie, Andrew, Willis, Gemma, Young, Susan, Poinasamy, Krisnah, Walker, Samantha, Jarrold, Ian, Rawlik, Konrad, Sanderson, Amy, Chong-James, K, David, C, James, W Y, Pfeffer, Paul, Zongo, O, Martineau, Adrian, Manisty, C, Armour, Cherie, Brown, Vanessa, Busby, John, Connolly, Bronwen, Craig, Thelma, Drain, Stephen, Heaney, Liam, King, Bernie, Magee, Nick, Major, E, McAulay, Danny, McGarvey, Lorcan, McGinness, Jade, Peto, Tunde, Stone, Roisin, Bolger, Annette, Davies, Ffyon, Haggar, Ahmed, Lewis, Joanne, Lloyd, Arwel, Manley, R, McIvor, Emma, Menzies, Daniel, Roberts, K, Saxon, W, Southern, David, Subbe, Christian, Whitehead, Victoria, Bularga, Anda, Mills, Nicholas, Dawson, Joy, El-Taweel, Hosni, Robinson, Leanne, Brear, Lucy, Regan, Karen, Saralaya, Dinesh, Storton, Kim, Amoils, Shannon, Bermperi, Areti, Cruz, Isabel, Dempsey, K, Elmer, Anne, Fuld, Jonathon, Jones, H, Jose, Sherly, Marciniak, Stefan, Parkes, M, Ribeiro, Carla, Taylor, Jessica, Toshner, Mark, Watson, L, Worsley, J, Broad, Lauren, Evans, Teriann, Haynes, Matthew, Jones, L, Knibbs, Lucy, McQueen, Alison, Oliver, Catherine, Paradowski, Kerry, Sabit, Ramsey, Williams, Jenny, Jones, Ian, Milligan, Lea, Harris, Edward, Sampson, Claire, Davies, Ellie, Evenden, Cerys, Hancock, Alyson, Hancock, Kia, Lynch, Ceri, Rees, Meryl, Roche, Lisa, Stroud, Natalie, Thomas-Woods, T, Heller, Simon, Chalder, Trudie, Shah, Kamini, Robertson, Elizabeth, Young, Bob, Babores, Marta, Holland, Maureen, Keenan, Natalie, Shashaa, Sharlene, Wassall, Helen, Austin, Liam, Beranova, Eva, Cosier, Tracey, Deery, Joanne, Hazelton, Tracy, Price, Carly, Ramos, Hazel, Solly, Reanne, Turney, Sharon, Weston, Heather, Coughlan, Eamon, Ralser, Markus, Pearce, Lorraine, Pugmire, S, Stoker, Wendy, Wilson, Ann, McCormick, W, Fraile, Eva, Ugoji, Jacinta, Aguilar Jimenez, Laura, Arbane, Gill, Betts, Sarah, Bisnauthsing, Karen, Dewar, A, Hart, Nicholas, Kaltsakas, G, Kerslake, Helen, Magtoto, Murphy, Marino, Philip, Martinez, L M, Ostermann, Marlies, Rossdale, Jennifer, Solano, Teresa, Alvarez Corral, Maria, Arias, Ava Maria, Bevan, Emily, Griffin, Denise, Martin, Jane, Owen, J, Payne, Sheila, Prabhu, A, Reed, Annabel, Storrar, Will, Williams, Nick, Wrey Brown, Caroline, Burdett, Tracy, Featherstone, James, Lawson, Cathy, Layton, Alison, Mills, Clare, Stephenson, Lorraine, Ellis, Yvette, Atkin, Paul, Brindle, K, Crooks, Michael, Drury, Katie, Easom, Nicholas, Flockton, Rachel, Holdsworth, L, Richards, A, Sykes, D L, Thackray-Nocera, Susannah, Wright, C, Coetzee, S, Davies, Kim, Hughes, Rachel Ann, Loosley, Ronda, McGuinness, Heather, Mohamed, Abdelrahman, O'Brien, Linda, Omar, Zohra, Perkins, Emma, Phipps, Janet, Ross, Gavin, Taylor, Abigail, Tench, Helen, Wolf-Roberts, Rebecca, Burden, L, Calvelo, Ellen, Card, Bethany, Carr, Caitlin, Chilvers, Edwin, Copeland, Donna, Cullinan, P, Daly, Patrick, Evison, Lynsey, Fayzan, Tamanah, Gordon, Hussain, Haq, Sulaimaan, Jenkins, Gisli, King, Clara, Kon, Onn Min, March, Katherine, Mariveles, Myril, McLeavey, Laura, Mohamed, Noura, Moriera, Silvia, Munawar, Unber, Nunag, Jose Lloyd, Nwanguma, Uchechi, Orriss-Dib, Lorna, Ross, Alexandra, Roy, Maura, Russell, Emily, Samuel, Katherine, Schronce, J, Simpson, Neil, Tarusan, Lawrence, Thomas, David, Wood, Chloe, Yasmin, Najira, Altmann, Danny, Howard, Luke, Johnston, Desmond, Lingford-Hughes, Anne, Man, William, Mitchell, Jane, Molyneaux, Philip, Nicolaou, Christos, O'Regan, D P, Price, L, Quint, Jenni, Smith, David, Thwaites, Ryan, Valabhji, Jonathon, Walsh, Simon, Efstathiou, Claudia, Liew, Felicity, Frankel, Anew, Lightstone, Liz, McAdoo, Steve, Wilkins, Martin, Willicombe, Michelle, Touyz, R, Guerdette, Anne-Marie, Hewitt, Melanie, Reddy, R, Warwick, Katie, White, Sonia, McMahon, Aisling, Adeyemi, Oluwaseun, Adrego, Rita, Assefa-Kebede, Hosanna, Breeze, Jonathon, Byrne, S, Dulawan, Pearl, Hoare, Amy, Jolley, Caroline, Knighton, Abigail, Patale, Sheetal, Peralta, Ida, Powell, Natassia, Ramos, Albert, Shevket, K, Speranza, Fabio, Te, Amelie, Malim, M, Bramham, Kate, Brown, M, Ismail, Khalida, Nicholson, Tim, Pariante, Carmen, Sharpe, Claire, Wessely, Simon, Whitney, J, Shah, Ajay, Chiribiri, A, O'Brien, C, Hayday, A, Ashworth, Andrew, Beirne, Paul, Clarke, Jude, Coupland, C, Dalton, Matthhew, Favager, Clair, Glossop, Jodie, Greenwood, John, Hall, Lucy, Hardy, Tim, Humphries, Amy, Murira, Jennifer, Peckham, Dan, Plein, S, Rangeley, Jade, Saalmink, Gwen, Tan, Ai Lyn, Wade, Elaine, Whittam, Beverley, Window, Nicola, Woods, Janet, Coakley, G, Turtle, Lance, Allerton, Lisa, Allt, Ann Marie, Beadsworth, M, Berridge, Anthony, Brown, Jo, Cooper, Shirley, Cross, Andy, Defres, Sylviane, Dobson, S L, Earley, Joanne, French, N, Greenhalf, William, Hainey, Kera, Hardwick, Hayley, Hawkes, Jenny, Highett, Victoria, Kaprowska, Sabina, Key, Angela, Lavelle-Langham, Lara, Lewis-Burke, N, Madzamba, Gladys, Malein, Flora, Marsh, Sophie, Mears, Chloe, Melling, Lucy, Noonan, Matthew, Poll, L, Pratt, James, Richardson, Emma, Rowe, Anna, Semple, Calum, Shaw, Victoria, Tripp, K A, Wajero, Lilian, Williams-Howard, S A, Wootton, Dan, Wyles, J, Diwanji, Shalin, Gurram, Sambasivarao, Papineni, Padmasayee, Quaid, Sheena, Tiongson, Gerlynn, Watson, Ekaterina, Briggs, Andrew, Marks, Michael, Hastie, Claire, Rogers, Natalie, Smith, Nikki, Stensel, David, Bishop, Lettie, McIvor, Katherine, Rivera-Ortega, Pilar, Al-Sheklly, Bashar, Avram, Cristina, Blaikely, John, Buch, M, Choudhury, N, Faluyi, David, Felton, T, Gorsuch, T, Hanley, Neil, Horsley, Alex, Hussell, Tracy, Kausar, Zunaira, Odell, Natasha, Osbourne, Rebecca, Piper Hanley, Karen, Radhakrishnan, K, Stockdale, Sue, Kabir, Thomas, Scott, Janet, Stewart, Iain, Openshaw, Peter, Burn, David, Ayoub, A, Brown, J, Burns, G, Davies, Gareth, De Soyza, Anthony, Echevarria, Carlos, Fisher, Helen, Francis, C, Greenhalgh, Alan, Hogarth, Philip, Hughes, Joan, Jiwa, Kasim, Jones, G, MacGowan, G, Price, D, Sayer, Avan, Simpson, John, Tedd, H, Thomas, S, West, Sophie, Witham, M, Wright, S, Young, A, McMahon, Michael, Neill, Paula, Anderson, David, Basu, Neil, Bayes, Hannah, Brown, Ammani, Dougherty, Andrew, Fallon, K, Gilmour, L, Grieve, D, Mangion, K, Morrow, A, Sykes, R, Berry, Colin, McInnes, I B, Scott, Kathryn, Barrett, Fiona, Donaldson, A, Sage, Beth, Bell, Murdina, Brown, Angela, Brown, M, Hamil, R, Leitch, Karen, Macliver, L, Patel, Manish, Quigley, Jackie, Smith, Andrew, Welsh, B, Choudhury, Gaunab, Clohisey, S, Deans, Andrew, Docherty, Annemarie, Furniss, J, Harrison, Ewen, Kelly, S, Sheikh, Aziz, Chalmers, James, Connell, David, Deas, C, Elliott, Anne, George, J, Mohammed, S, Rowland, J, Solstice, AR, Sutherland, Debbie, Tee, Caroline, Bunker, Jenny, Gill, Rhyan, Nathu, Rashmita, Holmes, Katie, Adamali, H, Arnold, David, Barratt, Shaney, Dipper, A, Dunn, Sarah, Maskell, Nick, Morley, Anna, Morrison, Leigh, Stadon, Louise, Waterson, Samuel, Welch, H, Jayaraman, Bhagy, Light, Tessa, Vogiatzis, Ioannis, Almeida, Paula, Bolton, Charlotte, Hosseini, Akram, Matthews, Laura, Needham, Robert, Shaw, Karen, Thomas, Andrew, Bonnington, J, Chrystal, Melanie, Dupont, Catherine, Greenhaff, Paul, Gupta, Ayushman, Jang, W, Linford, S, Nikolaidis, Athanasios, Prosper, Sabrina, Burns, A, Kanellakis, N, Ferreira, V, Nikolaidou, C, Xie, C, Ainsworth, Mark, Alamoudi, Asma, Bloss, Angela, Carter, Penny, Cassar, M, Chen, Jin, Conneh, Florence, Dong, T, Evans, Ranuromanana, Fraser, Emily, Geddes, John, Gleeson, F, Harrison, Paul, Havinden-Williams, May, Ho, Ling Pei, Jezzard, P, Koychev, Ivan, Kurupati, Prathiba, McShane, H, Megson, Clare, Neubauer, Stefan, Nicoll, Debby, Ogg, G, Pacpaco, Edmund, Pavlides, M, Peng, Yanchun, Petousi, Nayia, Pimm, John, Rahman, Najib, Raman, Betty, Rowland, M J, Saunders, Kathryn, Sharpe, Michael, Talbot, Nick, Tunnicliffe, E M, Korszun, Ania, Kerr, Steven, Barker, R E, Cristiano, Daniele, Dormand, N, George, P, Gummadi, Mahitha, Kon, S, Liyanage, Kamal, Nolan, C M, Patel, B, Patel, Suhani, Polgar, Oliver, Price, L, Shah, P, Singh, Suver, Walsh, J A, Gibbons, Michael, Ahmad, Shanaz, Brill, Simon, Hurst, John, Jarvis, Hannah, Lim, Lai, Mandal, S, Matila, Darwin, Olaosebikan, Olaoluwa, Singh, Claire, Laing, C, Baxendale, Helen, Garner, Lucie, Johnson, C, Mackie, J, Michael, Alice, Newman, J, Pack, Jamie, Paques, K, Parfrey, H, Parmar, J, Reddy, A, Halling-Brown, Mark, Dark, P, Diar-Bakerly, Nawar, Evans, D, Hardy, E, Harvey, Alice, Holgate, D, Knight, Sean, Mairs, N, Majeed, N, McMorrow, L, Oxton, J, Pendlebury, Jessica, Summersgill, C, Ugwuoke, R, Whittaker, S, Matimba-Mupaya, Wadzanai, Strong-Sheldrake, Sophia, Chowienczyk, Phillip, Bagshaw, J, Begum, M, Birchall, K, Butcher, Robyn, Carborn, H, Chan, Flora, Chapman, Kerry, Cheng, Yutung, Chetham, Luke, Clark, Cameron, Coburn, Zach, Cole, Joby, Dixon, Myles, Fairman, Alexandra, Finnigan, J, Foot, H, Foote, David, Ford, Amber, Gregory, Rebecca, Harrington, Kate, Haslam, L, Hesselden, L, Hockridge, J, Holbourn, Ailsa, Holroyd-Hind, B, Holt, L, Howell, Alice, Hurditch, E, Ilyas, F, Jarman, Claire, Lawrie, Allan, Lee, Ju Hee, Lee, Elvina, Lenagh, Rebecca, Lye, Alison, Macharia, Irene, Marshall, M, Mbuyisa, Angeline, McNeill, J, Megson, Sharon, Meiring, J, Milner, L, Misra, S, Newell, Helen, Newman, Tom, Norman, C, Nwafor, Lorenza, Pattenadk, Dibya, Plowright, Megan, Porter, Julie, Ravencroft, Phillip, Roddis, C, Rodger, J, Rowland-Jones, Sarah, Saunders, Peter, Sidebottom, J, Smith, Jacqui, Smith, Laurie, Steele, N, Stephens, G, Stimpson, R, Thamu, B, Thompson, A. A. Roger, Tinker, N, Turner, Kim, Turton, Helena, Wade, Phillip, Walker, S, Watson, James, Wilson, Imogen, Zawia, Amira, Allsop, Lynne, Bennett, Kaytie, Buckley, Phil, Flynn, Margaret, Gill, Mandy, Goodwin, Camelia, Greatorex, M, Gregory, Heidi, Heeley, Cheryl, Holloway, Leah, Holmes, Megan, Hutchinson, John, Kirk, Jill, Lovegrove, Wayne, Sewell, Terri Ann, Shelton, Sarah, Sissons, D, Slack, Katie, Smith, Susan, Sowter, D, Turner, Sarah, Whitworth, V, Wynter, Inez, Tomlinson, Johanne, Warburton, Louise, Painter, Sharon, Palmer, Sue, Redwood, Dawn, Tilley, Jo, Vickers, Carinna, Wainwright, Tania, Breen, G, Hotopf, M, Aul, Raminder, Forton, D, Ali, Mariam, Dunleavy, A, Mencias, Mark, Msimanga, N, Samakomva, T, Siddique, Sulman, Tavoukjian, Vera, Teixeira, J, Ahmed, Rubina, Francis, Richard, Connor, Lynda, Cook, Amanda, Davies, Gwyneth, Rees, Tabitha, Thaivalappil, Favas, Thomas, Caradog, McNarry, M, Williams, N, Lewis, Keir, Coulding, Martina, Jones, Heather, Kilroy, Susan, McCormick, Jacqueline, McIntosh, Jerome, Turner, Victoria, Vere, Joanne, Butt, Al-Tahoor, Savill, Heather, Kon, Samantha, Landers, G, Lota, Harpreet, Portukhay, Sofiya, Nasseri, Mariam, Daniels, Alison, Hormis, Anil, Ingham, Julie, Zeidan, Lisa, Chablani, Manish, Osborne, Lynn, Aslani, Shahab, Banerjee, Amita, Batterham, R, Baxter, Gabrielle, Bell, Robert, David, Anthony, Denneny, Emma, Hughes, Alun, Lilaonitkul, W, Mehta, P, Pakzad, Ashkan, Rangelov, Bojidar, Williams, B, Willoughby, James, Xu, Moucheng, Ahwireng, Nyarko, Bang, Dongchun, Basire, Donna, Brown, Jeremy, Chambers, Rachel, Checkley, A, Evans, R, Heightman, M, Hillman, T, Jacob, Joseph, Jastrub, Roman, Lipman, M, Logan, S, Lomas, D, Merida Morillas, Marta, Plant, Hannah, Porter, Joanna, Roy, K, Wall, E, Treibel, T, Ahmad Haider, N, Atkin, Catherine, Baggott, Rhiannon, Bates, Michelle, Botkai, A, Casey, Anna, Cooper, B, Dasgin, Joanne, Dawson, Camilla, Draxlbauer, Katharine, Gautam, N, Hazeldine, J, Hiwot, T, Holden, Sophie, Isaacs, Karen, Jackson, T, Kamwa, Vicky, Lewis, D, Lord, Janet, Madathil, S, McGee, C, Mcgee, K, Neal, Aoife, Newton-Cox, Alex, Nyaboko, Joseph, Parekh, Dhruv, Peterkin, Z, Qureshi, H, Ratcliffe, Liz, Sapey, Elizabeth, Short, J, Soulsby, Tracy, Stockley, J, Suleiman, Zehra, Thompson, Tamika, Ventura, Maximina, Walder, Sinead, Welch, Carly, Wilson, Daisy, Yasmin, S, Yip, Kay Por, Chaudhuri, N, Childs, Caroline, Djukanovic, R, Fletcher, S, Harvey, Matt, Jones, Mark, Marouzet, Elizabeth, Marshall, B, Samuel, Reena, Sass, T, Wallis, Tim, Wheeler, Helen, Steeds, R, Beckett, Paul, Dickens, Caroline, Nanda, Uttam, Aljaroof, M, Armstrong, Natalie, Arnold, H, Aung, Hnin, Bakali, Majda, Bakau, M, Baldry, E, Baldwin, Molly, Bourne, Charlotte, Bourne, Michelle, Brightling, Chris, Brunskill, Nigel, Cairns, P, Carr, Liesel, Charalambou, Amanda, Christie, C, Davies, Melanie, Daynes, Enya, Diver, Sarah, Dowling, Rachael, Edwards, Sarah, Edwardson, C, Elneima, Omer, Evans, H, Evans, Rachael, Finch, J, Glover, Sarah, Goodman, Nicola, Gooptu, Bibek, Greening, Neil, Hadley, Kate, Haldar, Pranab, Hargadon, Beverley, Harris, Victoria, Houchen-Wolloff, Linzy, Ibrahim, W, Ingram, L, Khunti, Kamlesh, Lea, A, Lee, D, McAuley, Hamish, McCann, Gerry, McCourt, P, Mcnally, Teresa, Mills, George, Monteiro, Will, Pareek, Manish, Parker, S, Prickett, Anne, Qureshi, I N, Rowland, A, Russell, Richard, Sereno, Marco, Shikotra, Aarti, Siddiqui, Salman, Singapuri, Ananga, Singh, Sally, Skeemer, J, Soares, M, Stringer, E, Thornton, T, Tobin, Martin, Ward, T J C, Woodhead, F, Yates, Tom, Yousuf, A J, Broome, Mattew, McArdle, Paul, Thickett, David, Upthegrove, Rachel, Wilkinson, Dan, Moss, Paul, Wraith, David, Evans, Jonathon, Bullmore, Ed, Heeney, Jonathon, Langenberg, Claudia, Schwaeble, William, Summers, Charlotte, Weir McCall, J, Adeloye, Davies, Newby, D E, Pius, Riinu, Rudan, Igor, Shankar-Hari, Manu, Sudlow, Catherine, Thorpe, Mat, Walmsley, Sarah, Zheng, Bang, Allan, Louise, Ballard, Clive, McGovern, Andrew, Dennis, J, Cavanagh, Jonathon, MacDonald, S, O'Donnell, Kate, Petrie, John, Sattar, Naveed, Spears, Mark, Guthrie, Elspeth, Henderson, Max, Allen, Richard, Bingham, Michelle, Brugha, Terry, Finney, Selina, Free, Rob, Jones, Don, Lawson, Claire, Lucy, Gardiner, Moss, Alistair, Mukaetova-Ladinska, Elizabeta, Novotny, Petr, Overton, Charlotte, Pearl, John, Plekhanova, Tatiana, Richardson, M, Samani, Nilesh, Sargant, Jack, Sharma, M, Steiner, Mike, Taylor, Chris, Terry, Sarah, Tong, C, Turner, E, Wormleighton, J, Zhao, Bang, Ntotsis, Kimon, Saunders, Ruth, Lozano-Rojas, Daniel, Goemans, Anne, Cuthbertson, D, Kemp, G, McArdle, Anne, Michael, Benedict, Reynolds, Will, Spencer, Lisa, Vinson, Ben, Ashworth, M, Abel, Kathryn, Chinoy, H, Deakin, Bill, Harvie, M, Miller, C A, Stanel, Stefan, Barran, Perdita, Trivedi, Drupad, McAllister-Williams, Hamish, Paddick, Stella-Maria, Rostron, Anthony, Taylor, John Paul, Baguley, David, Coleman, Chris, Cox, E, Fabbri, Laura, Francis, Susan, Hall, Ian, Hufton, E, Johnson, Simon, Khan, Fasih, Kitterick, Paaig, Morriss, Richard, Selby, Nick, Wright, Louise, Antoniades, Charalambos, Bates, A, Beggs, M, Bhui, Kamaldeep, Breeze, Katie, Channon, K M, Clark, David, Fu, X, Husain, Masud, Li, X, Lukaschuk, E, McCracken, Celeste, McGlynn, K, Menke, R, Motohashi, K, Nichols, T E, Ogbole, Godwin, Piechnik, S, Propescu, I, Propescu, J, Samat, A A, Sanders, Z B, Sigfrid, Louise, Webster, M, Kingham, Lucy, Klenerman, Paul, Lamlum, Hanan, Taquet, Maxime, Carson, G, Finnigan, L, Saunders, Laura, Wild, James, Calder, P C, Huneke, Nathan, Simons, Gemma, Baldwin, David, Bain, Steve, Daines, Luke, Bright, E, Crisp, P, Dharmagunawardena, Ruvini, Stern, M, Bailey, Elisabeth, Reddington, Anne, Wight, Andrew, Ashish, A, Cooper, Josh, Robinson, Emma, Broadley, Andrew, Barman, Laura, Brookes, Claire, Elliott, K, Griffiths, L, Guy, Zoe, Howard, Kate, Ionita, Diana, Redfearn, Heidi, Sarginson, Carol, and Turnbull, Alison
Abstract: COVID-19 is known to be associated with increased risks of cognitive and psychiatric outcomes after the acute phase of disease. We aimed to assess whether these symptoms can emerge or persist more than 1 year after hospitalisation for COVID-19, to identify which early aspects of COVID-19 illness predict longer-term symptoms, and to establish how these symptoms relate to occupational functioning.
Published: 2024
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11. Network topology and functional connectivity disturbances precede the onset of Huntington’s disease

Author: Harrington, Deborah L, Rubinov, Mikail, Durgerian, Sally, Mourany, Lyla, Reece, Christine, Koenig, Katherine, Bullmore, Ed, Long, Jeffrey D, Paulsen, Jane S, and Rao, Stephen M
Subjects: Rare Diseases, Neurodegenerative, Brain Disorders, Huntington's Disease, Neurosciences, Clinical Research, Prevention, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Neurological, Adult, Aged, Brain, Brain Mapping, Executive Function, Female, Humans, Huntington Disease, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neuropsychological Tests, Huntington disease, resting-state connectivity, network topology, graph theory, network based statistic, PREDICT-HD investigators of the Huntington Study Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract: Cognitive, motor and psychiatric changes in prodromal Huntington's disease have nurtured the emergent need for early interventions. Preventive clinical trials for Huntington's disease, however, are limited by a shortage of suitable measures that could serve as surrogate outcomes. Measures of intrinsic functional connectivity from resting-state functional magnetic resonance imaging are of keen interest. Yet recent studies suggest circumscribed abnormalities in resting-state functional magnetic resonance imaging connectivity in prodromal Huntington's disease, despite the spectrum of behavioural changes preceding a manifest diagnosis. The present study used two complementary analytical approaches to examine whole-brain resting-state functional magnetic resonance imaging connectivity in prodromal Huntington's disease. Network topology was studied using graph theory and simple functional connectivity amongst brain regions was explored using the network-based statistic. Participants consisted of gene-negative controls (n = 16) and prodromal Huntington's disease individuals (n = 48) with various stages of disease progression to examine the influence of disease burden on intrinsic connectivity. Graph theory analyses showed that global network interconnectivity approximated a random network topology as proximity to diagnosis neared and this was associated with decreased connectivity amongst highly-connected rich-club network hubs, which integrate processing from diverse brain regions. However, functional segregation within the global network (average clustering) was preserved. Functional segregation was also largely maintained at the local level, except for the notable decrease in the diversity of anterior insula intermodular-interconnections (participation coefficient), irrespective of disease burden. In contrast, network-based statistic analyses revealed patterns of weakened frontostriatal connections and strengthened frontal-posterior connections that evolved as disease burden increased. These disturbances were often related to long-range connections involving peripheral nodes and interhemispheric connections. A strong association was found between weaker connectivity and decreased rich-club organization, indicating that whole-brain simple connectivity partially expressed disturbances in the communication of highly-connected hubs. However, network topology and network-based statistic connectivity metrics did not correlate with key markers of executive dysfunction (Stroop Test, Trail Making Test) in prodromal Huntington's disease, which instead were related to whole-brain connectivity disturbances in nodes (right inferior parietal, right thalamus, left anterior cingulate) that exhibited multiple aberrant connections and that mediate executive control. Altogether, our results show for the first time a largely disease burden-dependent functional reorganization of whole-brain networks in prodromal Huntington's disease. Both analytic approaches provided a unique window into brain reorganization that was not related to brain atrophy or motor symptoms. Longitudinal studies currently in progress will chart the course of functional changes to determine the most sensitive markers of disease progression.
Published: 2015

12. Neuroscience Needs Network Science

Author: Barabási, Dániel L., primary, Bianconi, Ginestra, additional, Bullmore, Ed, additional, Burgess, Mark, additional, Chung, SueYeon, additional, Eliassi-Rad, Tina, additional, George, Dileep, additional, Kovács, István A., additional, Makse, Hernán, additional, Nichols, Thomas E., additional, Papadimitriou, Christos, additional, Sporns, Olaf, additional, Stachenfeld, Kim, additional, Toroczkai, Zoltán, additional, Towlson, Emma K., additional, Zador, Anthony M., additional, Zeng, Hongkui, additional, Barabási, Albert-László, additional, Bernard, Amy, additional, and Buzsáki, György, additional
Published: 2023
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13. Early adversity changes the economic conditions of mouse structural brain network organization

Author: Carozza, Sofia, primary, Holmes, Joni, additional, Vértes, Petra E., additional, Bullmore, Ed, additional, Arefin, Tanzil M., additional, Pugliese, Alexa, additional, Zhang, Jiangyang, additional, Kaffman, Arie, additional, Akarca, Danyal, additional, and Astle, Duncan E., additional
Published: 2023
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14. Quantitative evaluation of simulated functional brain networks in graph theoretical analysis

Author: Lee, Won Hee, Bullmore, Ed, and Frangou, Sophia
Published: 2017
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15. The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism

Author: Uzefovsky, Florina, Bethlehem, Richard A. I., Shamay-Tsoory, Simone, Ruigrok, Amber, Holt, Rosemary, Spencer, Michael, Chura, Lindsay, Warrier, Varun, Chakrabarti, Bhismadev, Bullmore, Ed, Suckling, John, Floris, Dorothea, and Baron-Cohen, Simon
Published: 2019
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16. Brain growth charts of “clinical controls” for quantitative analysis of clinically acquired brain MRI

Author: Schabdach, Jenna M., primary, Schmitt, J. Eric, additional, Sotardi, Susan, additional, Vossough, Arastoo, additional, Andronikou, Savvas, additional, Roberts, Timothy P., additional, Huang, Hao, additional, Padmanabhan, Viveknarayanan, additional, Oritz-Rosa, Alfredo, additional, Gardner, Margaret, additional, Covitz, Sydney, additional, Bedford, Saashi A., additional, Mandal, Ayan, additional, Chaiyachati, Barbara H., additional, White, Simon R., additional, Bullmore, Ed, additional, Bethlehem, Richard A.I., additional, Shinohara, Russell T., additional, Billot, Benjamin, additional, Iglesias, J. Eugenio, additional, Ghosh, Satrajit, additional, Gur, Raquel E., additional, Satterthwaite, Theodore D., additional, Roalf, David, additional, Seidlitz, Jakob, additional, and Alexander-Bloch, Aaron, additional
Published: 2023
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17. Idiosyncratic responding during movie-watching predicted by age differences in attentional control

Author: Tyler, Lorraine K., Brayne, Carol, Bullmore, Ed, Calder, Andrew, Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Henson, Rik, Matthews, Fiona, Marslen-Wilson, William, Rowe, James, Shafto, Meredith, Campbell, Karen, Cheung, Teresa, Davis, Simon, Geerligs, Linda, Kievit, Rogier, McCarrey, Anna, Price, Darren, Taylor, Jason, Tsvetanov, Kamen, Williams, Nitin, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewal, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Dixon, Marie, Barnes, Dan, Hillman, Jaya, Mitchell, Joanne, Villis, Laura, Campbell, Karen L., Shafto, Meredith A., Wright, Paul, and Tsvetanov, Kamen A.
Published: 2015
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18. Multi-Round Trust Game Quantifies Inter-Individual Differences in Social Exchange from Adolescence to Adulthood

Author: Hula, Andreas, Moutoussis, Michael, Will, Geert-Jan, Kokorikou, Danae, Reiter, Andrea M, Ziegler, Gabriel, NSPN Consortium, Bullmore, ED, Jones, Peter B, Goodyer, Ian, Fonagy, Peter, Montague, P Read, Dolan, Raymond J, Hula, Andreas [0000-0003-4253-5604], Moutoussis, Michael [0000-0002-4751-0425], Will, Geert-Jan [0000-0003-1887-9829], Reiter, Andrea M [0000-0002-5209-3996], Ziegler, Gabriel [0000-0001-6589-6416], Bullmore, ED [0000-0002-8955-8283], Jones, Peter B [0000-0002-0387-880X], Goodyer, Ian [0000-0001-9183-0373], Fonagy, Peter [0000-0003-0229-0091], Montague, P Read [0000-0002-8967-0339], Dolan, Raymond J [0000-0001-9356-761X], and Apollo - University of Cambridge Repository
Subjects: NSPN Consortium, I-POMDP, 2.3 Psychological, social and economic factors, Adolescent, Sample (statistics), Development, Trust, Basic Behavioral and Social Science, Developmental psychology, IQ Effects, Age, Dictator game, Behavioral and Social Science, ddc:610, Young adult, 10 Reduced Inequalities, Socioeconomic status, Socio-Economic Status, Pediatric, 2 Aetiology, Risk aversion, Model Based, General Arts and Humanities, Cognition, Risk Aversion, Gender Difference, Social exchange theory, Mental health, Psychology, Inequity aversion
Abstract: Investing in strangers in a socio-economic exchange is risky, as we may be uncertain whether they will reciprocate. Nevertheless, the potential rewards for cooperating can be great. Here, we used a cross sectional sample (n = 784) to study how the challenges of cooperation versus defection are negotiated across an important period of the lifespan: from adolescence to young adulthood (ages 14 to 25). We quantified social behaviour using a multi round investor-trustee task, phenotyping individuals using a validated model whose parameters characterise patterns of real exchange and constitute latent social characteristics. We found highly significant differences in investment behaviour according to age, sex, socio-economic status and IQ. Consistent with the literature, we showed an overall trend towards higher trust from adolescence to young adulthood but, in a novel finding, we characterized key cognitive mechanisms explaining this, especially regarding socio-economic risk aversion. Males showed lower risk-aversion, associated with greater investments. We also found that inequality aversion was higher in females and, in a novel relation, that socio-economic deprivation was associated with more risk averse play. Published version
Published: 2021
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19. 20. INSIGHTS INTO CORTICAL ORGANISATION, DEVELOPMENT, AND EVOLUTION FROM GWAS OF 2,352 STRUCTURAL BRAIN PHENOTYPES

Author: Warrier, Varun, primary, Alexander-Bloch, Aaron, additional, Bullmore, Ed, additional, Gandal, Michael, additional, Grotzinger, Andrew, additional, Mallard, Travis, additional, Martin, Hilary, additional, Murray, Graham, additional, Romero-Garcia, Rafael, additional, Ronan, Lisa, additional, Seidlitz, Jakob, additional, Slob, Eric, additional, Stauffer, Eva-Maria, additional, Won, Hyejung, additional, and Bethlehem, Richard, additional
Published: 2022
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20. Early adversity changes the economic conditions of structural brain network organisation

Author: Carozza, Sofia, primary, Holmes, Joni, additional, Vértes, Petra E., additional, Bullmore, Ed, additional, Arefin, Tanzil M., additional, Pugliese, Alexa, additional, Zhang, Jiangyang, additional, Kaffman, Arie, additional, Akarca, Danyal, additional, and Astle, Duncan E., additional
Published: 2022
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21. Graph Convolutional Networks Reveal Network-Level Functional Dysconnectivity in Schizophrenia

Author: Lei, Du, primary, Qin, Kun, additional, Pinaya, Walter H L, additional, Young, Jonathan, additional, Van Amelsvoort, Therese, additional, Marcelis, Machteld, additional, Donohoe, Gary, additional, Mothersill, David O, additional, Corvin, Aiden, additional, Vieira, Sandra, additional, Lui, Su, additional, Scarpazza, Cristina, additional, Arango, Celso, additional, Bullmore, Ed, additional, Gong, Qiyong, additional, McGuire, Philip, additional, and Mechelli, Andrea, additional
Published: 2022
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22. Prefrontal connectomics: from anatomy to human imaging

Author: Haber, Suzanne N, Liu, Hesheng, Seidlitz, Jakob, Bullmore, Ed, Liu, Hesheng [0000-0002-7233-1509], Seidlitz, Jakob [0000-0002-8164-7476], and Apollo - University of Cambridge Repository
Subjects: mental disorders, Neural Pathways, Connectome, Animals, Brain, Humans, Prefrontal Cortex, Neuroimaging, Nerve Net, Magnetic Resonance Imaging, health care economics and organizations, humanities
Abstract: Funder: U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH), The fundamental importance of prefrontal cortical connectivity to information processing and, therefore, disorders of cognition, emotion, and behavior has been recognized for decades. Anatomic tracing studies in animals have formed the basis for delineating the direct monosynaptic connectivity, from cells of origin, through axon trajectories, to synaptic terminals. Advances in neuroimaging combined with network science have taken the lead in developing complex wiring diagrams or connectomes of the human brain. A key question is how well these magnetic resonance imaging (MRI)-derived networks and hubs reflect the anatomic "hard wiring" first proposed to underlie the distribution of information for large-scale network interactions. In this review, we address this challenge by focusing on what is known about monosynaptic prefrontal cortical connections in non-human primates and how this compares to MRI-derived measurements of network organization in humans. First, we outline the anatomic cortical connections and pathways for each prefrontal cortex (PFC) region. We then review the available MRI-based techniques for indirectly measuring structural and functional connectivity, and introduce graph theoretical methods for analysis of hubs, modules, and topologically integrative features of the connectome. Finally, we bring these two approaches together, using specific examples, to demonstrate how monosynaptic connections, demonstrated by tract-tracing studies, can directly inform understanding of the composition of PFC nodes and hubs, and the edges or pathways that connect PFC to cortical and subcortical areas.
Published: 2021
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23. Prefrontal connectomics: from anatomy to human imaging

Author: Haber, Suzanne N., primary, Liu, Hesheng, additional, Seidlitz, Jakob, additional, and Bullmore, Ed, additional
Published: 2021
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24. The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study

Author: Zhang, Yi, Luo, Qiang, Huang, Chu-Chung, Lo, Chun-Yi Zac, Langley, Christelle, Quinlan, Erin Burke, Banaschewski, Tobias, Millenet, Sabina, Bokde, Arun L W, Flor, Herta, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Poustka, Luise, Smolka, Michael N, Walter, Henrik, Whelan, Robert, Tsai, Shih-Jen, Lin, Ching-Po, Bullmore, Ed, Schumann, Gunter, Sahakian, Barbara J, Feng, Jianfeng, and for the IMAGEN consortium
Subjects: Cellular and Molecular Neuroscience, Cognitive Neuroscience
Abstract: Psychological androgyny has long been associated with greater cognitive flexibility, adaptive behavior, and better mental health, but whether a similar concept can be defined using neural features remains unknown. Using the neuroimaging data from 9620 participants, we found that global functional connectivity was stronger in the male brain before middle age but became weaker after that, when compared with the female brain, after systematic testing of potentially confounding effects. We defined a brain gender continuum by estimating the likelihood of an observed functional connectivity matrix to represent a male brain. We found that participants mapped at the center of this continuum had fewer internalizing symptoms compared with those at the 2 extreme ends. These findings suggest a novel hypothesis proposing that there exists a neuroimaging concept of androgyny using the brain gender continuum, which may be associated with better mental health in a similar way to psychological androgyny.
Published: 2021

25. Genetic variants associated with cross-disorder and disorder-specific risk for psychiatric disorders are enriched at epigenetically active sites in peripheral lymphoid cells

Author: Lynall, Mary-Ellen, primary, Soskic, Blagoje, additional, Hayhurst, James, additional, Schwartzentruber, Jeremy, additional, Levey, Daniel F., additional, Pathak, Gita A., additional, Polimanti, Renato, additional, Gelernter, Joel, additional, Stein, Murray B., additional, Trynka, Gosia, additional, Clatworthy, Menna R., additional, and Bullmore, Ed, additional
Published: 2021
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26. A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Author: Schubert, Julia J., primary, Veronese, Mattia, additional, Fryer, Tim D., additional, Manavaki, Roido, additional, Kitzbichler, Manfred G., additional, Nettis, Maria A., additional, Mondelli, Valeria, additional, Pariante, Carmine M., additional, Bullmore, Edward T., additional, Turkheimer, Federico E., additional, Wlazly, Dominika, additional, Dickinson, Amber, additional, Foster, Andy, additional, Knight, Clare, additional, Leckey, Claire, additional, Morgan, Paul, additional, Morgan, Angharad, additional, O'Hagan, Caroline, additional, Touchard, Samuel, additional, Khan, Shahid, additional, Murphy, Phil, additional, Parker, Christine, additional, Patel, Jai, additional, Richardson, Jill, additional, Acton, Paul, additional, Austin, Nigel, additional, Bhattacharya, Anindya, additional, Carruthers, Nick, additional, de Boer, Peter, additional, Drevets, Wayne, additional, Isaac, John, additional, Jones, Declan, additional, Kemp, John, additional, Kolb, Hartmuth, additional, Nye, Jeff, additional, Wittenberg, Gayle, additional, Barker, Gareth, additional, Bogdanova, Anna, additional, Byrom, Heidi, additional, Cash, Diana, additional, Cattaneo, Annamaria, additional, Enache, Daniela, additional, Gee, Tony, additional, Hastings, Caitlin, additional, Kose, Melisa, additional, Lombardo, Giulia, additional, Mariani, Nicole, additional, McLaughlin, Anna, additional, Nettis, Maria, additional, Nikkheslat, Naghmeh, additional, Pariante, Carmine, additional, Randall, Karen, additional, Schubert, Julia, additional, Sforzini, Luca, additional, Sheridan, Hannah, additional, Simmons, Camilla, additional, Singh, Nisha, additional, Turkheimer, Federico, additional, Van Loo, Vicky, additional, Rodriguez, Marta Vicente, additional, Wood, Toby, additional, Worrell, Courtney, additional, Zajkowska, Zuzanna, additional, Campbell, Brian, additional, Egebjerg, Jan, additional, Eriksson, Hans, additional, Gastambide, Francois, additional, Adams, Karen Husted, additional, Jeggo, Ross, additional, Moeller, Thomas, additional, Nelson, Bob, additional, Plath, Niels, additional, Thomsen, Christian, additional, Pederson, Jan Torleif, additional, Zorn, Stevin, additional, Deith, Catherine, additional, Farmer, Scott, additional, McClean, John, additional, McPherson, Andrew, additional, Penandes, Nagore, additional, Scouller, Paul, additional, Sutherland, Murray, additional, Attenburrow, Mary Jane, additional, Benjamin, Jithen, additional, Jones, Helen, additional, Mada, Fran, additional, Oladejo, Akintayo, additional, Smith, Katy, additional, Balice-Gordon, Rita, additional, Binneman, Brendon, additional, Duerr, James, additional, Fullerton, Terence, additional, Goli, Veeru, additional, Hughes, Zoe, additional, Piro, Justin, additional, Samad, Tarek, additional, Sporn, Jonathan, additional, Hoskins, Liz, additional, Kohn, Charmaine, additional, Wilcock, Lauren, additional, Aigbirhio, Franklin, additional, Bhatti, Junaid, additional, Bullmore, Ed, additional, Chamberlain, Sam, additional, Correia, Marta, additional, Crofts, Anna, additional, Fryer, Tim, additional, Graves, Martin, additional, Hatton, Alex, additional, Kitzbichler, Manfred, additional, Lynall, Mary-Ellen, additional, Maurice, Christina, additional, O'Donnell, Ciara, additional, Pointon, Linda, additional, St George Hyslop, Peter, additional, Turner, Lorinda, additional, Vertes, Petra, additional, Widmer, Barry, additional, Williams, Guy, additional, Cavanagh, Jonathan, additional, McColl, Alison, additional, Shaw, Robin, additional, Boddeke, Erik, additional, Baird, Alison, additional, Clare, Stuart, additional, Cowen, Phil, additional, Huang, I-Shu (Dante), additional, Hurley, Sam, additional, Lovestone, Simon, additional, Nevado-Holgado, Alejo, additional, Ribe, Elena, additional, Vyas, Anviti, additional, Winchester, Laura, additional, Cleal, Madeleine, additional, Gomez-Nicola, Diego, additional, Mancuso, Renzo, additional, Perry, Hugh, additional, Cercignani, Mara, additional, Clarke, Charlotte, additional, Colasanti, Alessandro, additional, Harrison, Neil, additional, Murray, Rosemary, additional, O'Connor, Jason, additional, and Mount, Howard, additional
Published: 2021
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27. Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom

Author: Török, M Estée, primary, Underwood, Benjamin R, additional, Toshner, Mark, additional, Waddington, Claire, additional, Sidhom, Emad, additional, Sharrocks, Katherine, additional, Bousfield, Rachel, additional, Summers, Charlotte, additional, Saunders, Caroline, additional, McIntyre, Zoe, additional, Morris, Helen, additional, Piper, Jo, additional, Calderon, Gloria, additional, Dennis, Sarah, additional, Assari, Tracy, additional, de Rotrou, Anita Marguerie, additional, Shaw, Ashley, additional, Bradley, John, additional, O’Brien, John, additional, Rintoul, Robert C, additional, Smith, Ian, additional, Bullmore, Ed, additional, Chatterjee, Krishna, additional, Ribeiro, Carla, additional, Pickup, Lorinda, additional, de Jesus, Ranalie, additional, Brookes, Karen, additional, Vargas, Phoebe, additional, McMahon, Caroline, additional, Macor, Chiara, additional, Pasquale, Ciro, additional, Bermperi, Areti, additional, Kourampa, Evgenia, additional, Fabiculcana, Marivic, additional, Zerudo, Julie Ann, additional, Mendoza, Vivien, additional, Fuller, Stewart, additional, Glemas, Claire, additional, Baker, Sharon, additional, Lyons, Greta, additional, Bishop, Marina, additional, Coleman, Siobhan, additional, Thomas, Naomi, additional, Mlilo, Vince, additional, Stanton, Edward, additional, Michel, Rachel, additional, Philips, Julie, additional, Rice, Heidi, additional, Garner, Lucie, additional, Rosa, Francesca, additional, Victor, Saji, additional, Zamikula, Julie, additional, Mepham, Sue, additional, Hajee, Fatima, additional, Quijano-Campos, Juan Carlos, additional, Watson, Laura, additional, Georgiou, Christopher, additional, Worsley, Jieniean, additional, Shamtally-Amode, Djamilla, additional, Rahimi, Ferishta, additional, Jones, Heather, additional, Cruz, Isabel, additional, Lindsay, Gayle, additional, Sparke, Christian, additional, Chapman, Anna, additional, Keating-Fedders, Katie, additional, Fahey, Codie, additional, Johnson, Danielle, additional, Worboys, Lucy, additional, Hargreaves, Simone, additional, Bucke, Ashlea, additional, Carr, Lindsay, additional, Hampshire, Jackie, additional, Richardson, Tracy, additional, Sharpe, Jenny, additional, Whitehead, Lynne, additional, Vyse, Naval, additional, Kelleher, Stephen, additional, Sherwood, Mary-Beth, additional, Hughes, Vicki, additional, and Giraud, Kim, additional
Published: 2021
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28. Why is non-suicidal self-injury more prevalent among women? Mediation and moderation analyses of psychological distress, emotion dysregulation, and impulsivity

Author: Lutz, Nina M., primary, Neufeld, Sharon A.S., additional, Hook, Roxanne W., additional, Jones, Peter B., additional, Bullmore, Ed T., additional, Goodyer, Ian M., additional, Chamberlain, Samuel R., additional, and Wilkinson, Paul O., additional
Published: 2021
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29. [11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease

Author: van den Ameele, Jelle, primary, Hong, Young T., additional, Manavaki, Roido, additional, Kouli, Antonina, additional, Biggs, Heather, additional, MacIntyre, Zoe, additional, Horvath, Rita, additional, Yu-Wai-Man, Patrick, additional, Reid, Evan, additional, Williams-Gray, Caroline H., additional, Bullmore, Ed T., additional, Aigbirhio, Franklin I., additional, Fryer, Tim D., additional, and Chinnery, Patrick F., additional
Published: 2021
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30. The scope of mental health research in the COVID-19 Pandemic and its aftermath

Author: Hotopf, Matthew, Bullmore, Ed, O'Connor, Rory C., and Holmes, Emily A.
Abstract: The effects of the COVID-19 pandemic on population mental health are unknown. We need to understand the scale of any such impact in different sections of the population, who is most affected and how best to mitigate, prevent and treat any excess morbidity. We propose a coordinated and interdisciplinary mental health science response.
Published: 2020

31. The scope of mental health research during the COVID-19 pandemic and its aftermath

Author: Hotopf, Matthew, Bullmore, Ed, O'Connor, Rory C., Holmes, Emily A., Hotopf, Matthew, Bullmore, Ed, O'Connor, Rory C., and Holmes, Emily A.
Abstract: The effects of the COVID-19 pandemic on population mental health are unknown. We need to understand the scale of any such impact in different sections of the population, who is most affected and how best to mitigate, prevent and treat any excess morbidity. We propose a coordinated and interdisciplinary mental health science response.
Published: 2020
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32. Multidisciplinary research priorities for the COVID-19 pandemic : a call for action for mental health science

Author: Holmes, Emily A., O'Connor, Rory C., Perry, V. Hugh, Tracey, Irene, Wessely, Simon, Arseneault, Louise, Ballard, Clive, Christensen, Helen, Silver, Roxane Cohen, Everall, Ian, Ford, Tamsin, John, Ann, Kabir, Thomas, King, Kate, Madan, Ira, Michie, Susan, Przybylski, Andrew K., Shafran, Roz, Sweeney, Angela, Worthman, Carol M., Yardley, Lucy, Cowan, Katherine, Cope, Claire, Hotopf, Matthew, Bullmore, Ed, Holmes, Emily A., O'Connor, Rory C., Perry, V. Hugh, Tracey, Irene, Wessely, Simon, Arseneault, Louise, Ballard, Clive, Christensen, Helen, Silver, Roxane Cohen, Everall, Ian, Ford, Tamsin, John, Ann, Kabir, Thomas, King, Kate, Madan, Ira, Michie, Susan, Przybylski, Andrew K., Shafran, Roz, Sweeney, Angela, Worthman, Carol M., Yardley, Lucy, Cowan, Katherine, Cope, Claire, Hotopf, Matthew, and Bullmore, Ed
Abstract: The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research. These priorities were informed by surveys of the public and an expert panel convened by the UK Academy of Medical Sciences and the mental health research charity, MQ: Transforming Mental Health, in the first weeks of the pandemic in the UK in March, 2020. We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time. The need to maintain high-quality research standards is imperative. International collaboration and a global perspective will be beneficial. An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19. There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19. Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required. Rising to this challenge will require integration across disciplines and sectors, and should be done together with people with lived experience. New funding will be required to meet these priorities, and it can be efficiently leveraged by the UK's world-leading infrastructure. This Position Paper provides a strategy that may be both adapted for, and integrated with, research, Emily A. Holmes and Rory C. O'Connor are joint first authors. Matthew Hotopf and Ed Bullmore are joint last authors.
Published: 2020
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33. Multidisciplinary research priorities for the COVID-19 pandemic : Authors' reply

Author: O'Connor, Rory C., Hotopf, Matthew, Worthman, Carol M., Perry, V. Hugh, Tracey, Irene, Wessely, Simon, Arseneault, Louise, Ballard, Clive, Christensen, Helen, Silver, Roxane Cohen, Ford, Tamsin, John, Ann, Kabir, Thomas, King, Kate, Simpson, Alan, Madan, Ira, Cowan, Katherine, Bullmore, Ed, Holmes, Emily A., O'Connor, Rory C., Hotopf, Matthew, Worthman, Carol M., Perry, V. Hugh, Tracey, Irene, Wessely, Simon, Arseneault, Louise, Ballard, Clive, Christensen, Helen, Silver, Roxane Cohen, Ford, Tamsin, John, Ann, Kabir, Thomas, King, Kate, Simpson, Alan, Madan, Ira, Cowan, Katherine, Bullmore, Ed, and Holmes, Emily A.
Published: 2020
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34. The scope of mental health research during the COVID-19 pandemic and its aftermath

Author: Hotopf, Matthew, primary, Bullmore, Ed, additional, O'Connor, Rory C., additional, and Holmes, Emily A., additional
Published: 2020
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35. Additional file 1: of The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism

Author: Uzefovsky, Florina, Bethlehem, Richard, Shamay-Tsoory, Simone, Ruigrok, Amber, Holt, Rosemary, Spencer, Michael, Chura, Lindsay, Varun Warrier, Bhismadev Chakrabarti, Bullmore, Ed, Suckling, John, Floris, Dorothea, and Baron-Cohen, Simon
Abstract: Figure S1. Analysis of residual head movement based on DVARS, which is a time series of the root mean squares (RMS) of the derivatives of the timecourses of all within-brain voxels for each volume. The analysis was conducted using code publishes by the Brain and Mind Lab at Aalto University, Finland. (PDF 345 kb)
Published: 2019
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36. Computational psychiatry of reinforcement learning: relation to psychotic illness, clinical risk of psychosis and polygenic risk for schizophrenia

Author: Montagnese, Marcella, Knolle, Franziska, Haarsma, Joost, Griffin, Juliet, Richards, Alex, Vertes, Petra, Kiddle, Bea, Owen, Michael, Jones, Peter, Moutoussis, Michael, Fonagy, Peter, Bullmore, Ed, Dolan, Ray, Goodyer, Ian, Fletcher, Paul, and Murray, Graham K
Published: 2019
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37. The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism

Author: Uzefovsky, Florina, Bethlehem, Richard AI, Shamay-Tsoory, Simone, Ruigrok, Amber, Holt, Rosemary, Spencer, Michael, Chura, Lindsay, Warrier, Varun, Chakrabarti, Bhismadev, Bullmore, Ed, Suckling, John, Floris, Dorothea, Baron-Cohen, Simon, Uzefovsky, Florina [0000-0003-4571-2514], and Apollo - University of Cambridge Repository
Subjects: Male, Adolescent, Genotype, Research, Autism, Emotions, fMRI, Brain, Supramarginal gyrus, Imaging genetics, Magnetic Resonance Imaging, Polymorphism, Single Nucleotide, lcsh:RC346-429, Receptors, Oxytocin, Humans, Female, Autistic Disorder, Child, Facial Recognition, Oxytocin receptor, lcsh:Neurology. Diseases of the nervous system
Abstract: Background Autism is a highly varied and heritable neurodevelopmental condition, and common variants explain approximately 50% of the genetic variance of autism. One of the genes implicated in autism is the oxytocin receptor (OXTR). The current study combined genetic and brain imaging (fMRI) data to examine the moderating effect of genotype on the association between diagnosis and brain activity in response to a test of cognitive empathy. Methods Participants were adolescents (mean age = 14.7 ± 1.7) who were genotyped for single nucleotide polymorphisms (SNPs) within the OXTR and underwent functional brain imaging while completing the adolescent version of the ‘Reading the Mind in the Eyes’ Test (Eyes Test). Results Two (rs2254298, rs53576) of the five OXTR SNPs examined were significantly associated with brain activity during the Eyes Test, and three of the SNPs (rs2254298, rs53576, rs2268491) interacted with diagnostic status to predict brain activity. All of the effects localized to the right supramarginal gyrus (rSMG) and an overlap analysis revealed a large overlap of the effects. An exploratory analysis showed that activity within an anatomically defined rSMG and genotype can predict diagnostic status with reasonable accuracy. Conclusions This is one of the first studies to investigate OXTR and brain function in autism. The findings suggest a neurogenetic mechanism by which OXTR-dependent activity within the rSMG is related to the aetiology of autism. Electronic supplementary material The online version of this article (10.1186/s13229-019-0258-4) contains supplementary material, which is available to authorized users.
Published: 2018

38. Developmental cognitive neuroscience using latent change score models: A tutorial and applications

Author: Kievit, Rogier A, Brandmaier, Andreas M, Ziegler, Gabriel, Van Harmelen, Anne-Laura, De Mooij, Susanne MM, Moutoussis, Michael, Goodyer, Ian M, Bullmore, Ed, Jones, Peter B, Fonagy, Peter, NSPN Consortium, Lindenberger, Ulman, Dolan, Raymond J, the Neuroscience in Psychiatry Network (NSPN) Consortium, Kievit, Rogier [0000-0003-0700-4568], van Harmelen, Anne-Laura [0000-0003-1108-2921], Goodyer, Ian [0000-0001-9183-0373], Bullmore, Edward [0000-0002-8955-8283], Jones, Peter [0000-0002-0387-880X], and Apollo - University of Cambridge Repository
Subjects: Change over time, Cognitive Neuroscience, Latent change scores, Developmental cognitive neuroscience, Context (language use), Development, Structural equation models, Article, Structural equation modeling, 050105 experimental psychology, Developmental psychology, Old-age, 03 medical and health sciences, 0302 clinical medicine, 0504 sociology, Extant taxon, Humans, Measurement invariance, 0501 psychology and cognitive sciences, ddc:610, methods [Cognitive Neuroscience], Individual-differences, Change score, White-matter microstructure, Models, Statistical, Covariance structure-analysis, Longitudinal data, lcsh:QP351-495, 05 social sciences, Likelihood ratio test, 050401 social sciences methods, Factorial invariance, Cognitive training, Variety (cybernetics), Adolescence, lcsh:Neurophysiology and neuropsychology, Cross-Sectional Studies, Structural equation modelling, Individual differences, Adolescent development, Psychology, Longitudinal modelling, Growth curve models, 030217 neurology & neurosurgery, Cognitive psychology
Abstract: Assessing and analysing individual differences in change over time is of central scientific importance to developmental neuroscience. However, the literature is based largely on cross-sectional comparisons, which reflect a variety of influences and cannot directly represent change. We advocate using latent change score (LCS) models in longitudinal samples as a statistical framework to tease apart the complex processes underlying lifespan development in brain and behaviour using longitudinal data. LCS models provide a flexible framework that naturally accommodates key developmental questions as model parameters and can even be used, with some limitations, in cases with only two measurement occasions. We illustrate the use of LCS models with two empirical examples. In a lifespan cognitive training study (COGITO, N=204 (N=32 imaging) on two waves) we observe correlated change in brain and behaviour in the context of a high-intensity training intervention. In an adolescent development cohort (NSPN, N=176, two waves) we find greater variability in cortical thinning in males than in females. To facilitate the adoption of LCS by the developmental community, we provide analysis code that can be adapted by other researchers and basic primers in two freely available SEM software packages (lavaan and Ωnyx).HighlightsWe describe Latent change score modelling as a flexible statistical toolKey developmental questions can be readily formalized using LCS modelsWe provide accessible open source code and software examples to fit LCS modelsWhite matter structural change is negatively correlated with processing speed gainsFrontal lobe thinning in adolescence is more variable in males than females
Published: 2018
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39. Integrating machining learning and multimodal neuroimaging to detect schizophrenia at the level of the individual

Author: Lei, Du, primary, Pinaya, Walter H. L., additional, Young, Jonathan, additional, van Amelsvoort, Therese, additional, Marcelis, Machteld, additional, Donohoe, Gary, additional, Mothersill, David O., additional, Corvin, Aiden, additional, Vieira, Sandra, additional, Huang, Xiaoqi, additional, Lui, Su, additional, Scarpazza, Cristina, additional, Arango, Celso, additional, Bullmore, Ed, additional, Gong, Qiyong, additional, McGuire, Philip, additional, and Mechelli, Andrea, additional
Published: 2019
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40. Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations

Author: Chamberlain, Samuel R, primary, Tiego, Jeggan, additional, Fontenelle, Leonardo F, additional, Hook, Roxanne, additional, Parkes, Linden, additional, Segrave, Rebecca, additional, Hauser, Tobias U, additional, Dolan, Ray J, additional, Goodyer, Ian M, additional, Bullmore, Ed, additional, Grant, Jon E, additional, and Yücel, Murat, additional
Published: 2019
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41. Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations

Author: Chamberlain, Samuel R., primary, Tiego, Jeggan, additional, Fontenelle, Leonardo F., additional, Hook, Roxanne, additional, Parkes, Linden, additional, Segrave, Rebecca, additional, Hauser, Tobias U., additional, Dolan, Ray J., additional, Goodyer, Ian M., additional, Bullmore, Ed, additional, Grant, Jon E., additional, and Yücel, Murat, additional
Published: 2019
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42. SA97COMPUTATIONAL PSYCHIATRY MEETS GENETICS: REINFORCEMENT LEARNING IN EARLY PSYCHOSIS AND IN RELATION TO CLINICAL AND MOLECULAR GENETIC RISK FOR SCHIZOPHRENIA

Author: Murray, Graham, primary, Montagnese, Marcella, additional, Knolle, Franziska, additional, Griffin, Juliet, additional, Haarsma, Joost, additional, Richards, Alexander, additional, Vertes, Petra, additional, Kiddle, Bea, additional, Owen, Michael, additional, Jones, Peter, additional, Fonagy, Peter, additional, Moutoussis, Michael, additional, Bullmore, Ed, additional, Dolan, Ray, additional, and Goodyer, Ian, additional
Published: 2019
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43. Integrating machining learning and multimodal neuroimaging to detect schizophrenia at the level of the individual.

Author: Lei, Du, Pinaya, Walter H. L., Young, Jonathan, Amelsvoort, Therese, Marcelis, Machteld, Donohoe, Gary, Mothersill, David O., Corvin, Aiden, Vieira, Sandra, Huang, Xiaoqi, Lui, Su, Scarpazza, Cristina, Arango, Celso, Bullmore, Ed, Gong, Qiyong, McGuire, Philip, and Mechelli, Andrea
Subjects: MACHINE learning, SUPPORT vector machines, COVARIANCE matrices, FUNCTIONAL magnetic resonance imaging, BRAIN abnormalities
Abstract: Schizophrenia is a severe psychiatric disorder associated with both structural and functional brain abnormalities. In the past few years, there has been growing interest in the application of machine learning techniques to neuroimaging data for the diagnostic and prognostic assessment of this disorder. However, the vast majority of studies published so far have used either structural or functional neuroimaging data, without accounting for the multimodal nature of the disorder. Structural MRI and resting‐state functional MRI data were acquired from a total of 295 patients with schizophrenia and 452 healthy controls at five research centers. We extracted features from the data including gray matter volume, white matter volume, amplitude of low‐frequency fluctuation, regional homogeneity and two connectome‐wide based metrics: structural covariance matrices and functional connectivity matrices. A support vector machine classifier was trained on each dataset separately to distinguish the subjects at individual level using each of the single feature as well as their combination, and 10‐fold cross‐validation was used to assess the performance of the model. Functional data allow higher accuracy of classification than structural data (mean 82.75% vs. 75.84%). Within each modality, the combination of images and matrices improves performance, resulting in mean accuracies of 81.63% for structural data and 87.59% for functional data. The use of all combined structural and functional measures allows the highest accuracy of classification (90.83%). We conclude that combining multimodal measures within a single model is a promising direction for developing biologically informed diagnostic tools in schizophrenia. [ABSTRACT FROM AUTHOR]
Published: 2020
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44. Developmental cognitive neuroscience using latent change score models: A tutorial and applications

Author: Kievit, Rogier A., primary, Brandmaier, Andreas M., additional, Ziegler, Gabriel, additional, van Harmelen, Anne-Laura, additional, de Mooij, Susanne M.M., additional, Moutoussis, Michael, additional, Goodyer, Ian M., additional, Bullmore, Ed, additional, Jones, Peter B., additional, Fonagy, Peter, additional, Lindenberger, Ulman, additional, and Dolan, Raymond J., additional
Published: 2018
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45. The Oxytocin Receptor Interacts with Autism Diagnosis To Predict Brain Activation In Response To The Eyes Test

Author: Uzefovsky, Florina, primary, Bethlehem, Richard, additional, Shamay-Tsoory, Simone, additional, Ruigrok, Amber, additional, Holt, Rosemary, additional, Spencer, Michael, additional, Chura, Lindsey, additional, Warrier, Varun, additional, Chakrabarti, Bhismadev, additional, Bullmore, Ed, additional, Suckling, John, additional, Floris, Dorothea, additional, and Baron-Cohen, Simon, additional
Published: 2017
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46. Idiosyncratic responding during movie-watching predicted by age differences in attentional control

Author: Campbell, Karen L., primary, Shafto, Meredith A., additional, Wright, Paul, additional, Tsvetanov, Kamen A., additional, Geerligs, Linda, additional, Cusack, Rhodri, additional, Tyler, Lorraine K., additional, Brayne, Carol, additional, Bullmore, Ed, additional, Calder, Andrew, additional, Dalgleish, Tim, additional, Duncan, John, additional, Henson, Rik, additional, Matthews, Fiona, additional, Marslen-Wilson, William, additional, Rowe, James, additional, Shafto, Meredith, additional, Campbell, Karen, additional, Cheung, Teresa, additional, Davis, Simon, additional, Kievit, Rogier, additional, McCarrey, Anna, additional, Price, Darren, additional, Taylor, Jason, additional, Tsvetanov, Kamen, additional, Williams, Nitin, additional, Bates, Lauren, additional, Emery, Tina, additional, Erzinçlioglu, Sharon, additional, Gadie, Andrew, additional, Gerbase, Sofia, additional, Georgieva, Stanimira, additional, Hanley, Claire, additional, Parkin, Beth, additional, Troy, David, additional, Allen, Jodie, additional, Amery, Gillian, additional, Amunts, Liana, additional, Barcroft, Anne, additional, Castle, Amanda, additional, Dias, Cheryl, additional, Dowrick, Jonathan, additional, Fair, Melissa, additional, Fisher, Hayley, additional, Goulding, Anna, additional, Grewal, Adarsh, additional, Hale, Geoff, additional, Hilton, Andrew, additional, Johnson, Frances, additional, Johnston, Patricia, additional, Kavanagh-Williamson, Thea, additional, Kwasniewska, Magdalena, additional, McMinn, Alison, additional, Norman, Kim, additional, Penrose, Jessica, additional, Roby, Fiona, additional, Rowland, Diane, additional, Sargeant, John, additional, Squire, Maggie, additional, Stevens, Beth, additional, Stoddart, Aldabra, additional, Stone, Cheryl, additional, Thompson, Tracy, additional, Yazlik, Ozlem, additional, Dixon, Marie, additional, Barnes, Dan, additional, Hillman, Jaya, additional, Mitchell, Joanne, additional, and Villis, Laura, additional
Published: 2015
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47. Semi-Metric Topology of the Human Connectome: Sensitivity and Specificity to Autism and Major Depressive Disorder

Author: Simas, Tiago, primary, Chattopadhyay, Shayanti, additional, Hagan, Cindy, additional, Kundu, Prantik, additional, Patel, Ameera, additional, Holt, Rosemary, additional, Floris, Dorothea, additional, Graham, Julia, additional, Ooi, Cinly, additional, Tait, Roger, additional, Spencer, Michael, additional, Baron-Cohen, Simon, additional, Sahakian, Barbara, additional, Bullmore, Ed, additional, Goodyer, Ian, additional, and Suckling, John, additional
Published: 2015
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48. Opening bottlenecks on weighted networks by local adaptation to cascade failures

Author: Alstott, Jeff, primary, Pajevic, Sinisa, additional, Bullmore, Ed, additional, and Plenz, Dietmar, additional
Published: 2015
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49. M12 - The Oxytocin Receptor Interacts with Autism Diagnosis To Predict Brain Activation In Response To The Eyes Test

Author: Uzefovsky, Florina, Bethlehem, Richard, Shamay-Tsoory, Simone, Ruigrok, Amber, Holt, Rosemary, Spencer, Michael, Chura, Lindsey, Warrier, Varun, Chakrabarti, Bhismadev, Bullmore, Ed, Suckling, John, Floris, Dorothea, and Baron-Cohen, Simon
Published: 2017
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50. A Modest Increase in 11C-PK11195-PET TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Author: Schubert, Julia J., Veronese, Mattia, Fryer, Tim D., Manavaki, Roido, Kitzbichler, Manfred G., Nettis, Maria A., Mondelli, Valeria, Pariante, Carmine M., Bullmore, Edward T., Wlazly, Dominika, Dickinson, Amber, Foster, Andy, Knight, Clare, Leckey, Claire, Morgan, Paul, Morgan, Angharad, O'Hagan, Caroline, Touchard, Samuel, Khan, Shahid, Murphy, Phil, Parker, Christine, Patel, Jai, Richardson, Jill, Acton, Paul, Austin, Nigel, Bhattacharya, Anindya, Carruthers, Nick, de Boer, Peter, Drevets, Wayne, Isaac, John, Jones, Declan, Kemp, John, Kolb, Hartmuth, Nye, Jeff, Wittenberg, Gayle, Barker, Gareth, Bogdanova, Anna, Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Enache, Daniela, Gee, Tony, Hastings, Caitlin, Kose, Melisa, Lombardo, Giulia, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Pariante, Carmine, Randall, Karen, Schubert, Julia, Sforzini, Luca, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Turkheimer, Federico, Van Loo, Vicky, Veronese, Mattia, Rodriguez, Marta Vicente, Wood, Toby, Worrell, Courtney, Zajkowska, Zuzanna, Campbell, Brian, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Moeller, Thomas, Nelson, Bob, Plath, Niels, Thomsen, Christian, Pederson, Jan Torleif, Zorn, Stevin, Deith, Catherine, Farmer, Scott, McClean, John, McPherson, Andrew, Penandes, Nagore, Scouller, Paul, Sutherland, Murray, Attenburrow, Mary Jane, Benjamin, Jithen, Jones, Helen, Mada, Fran, Oladejo, Akintayo, Smith, Katy, Balice-Gordon, Rita, Binneman, Brendon, Duerr, James, Fullerton, Terence, Goli, Veeru, Hughes, Zoe, Piro, Justin, Samad, Tarek, Sporn, Jonathan, Hoskins, Liz, Kohn, Charmaine, Wilcock, Lauren, Aigbirhio, Franklin, Bhatti, Junaid, Bullmore, Ed, Chamberlain, Sam, Correia, Marta, Crofts, Anna, Fryer, Tim, Graves, Martin, Hatton, Alex, Kitzbichler, Manfred, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy, Cavanagh, Jonathan, McColl, Alison, Shaw, Robin, Boddeke, Erik, Baird, Alison, Clare, Stuart, Cowen, Phil, Huang, I-Shu (Dante), Hurley, Sam, Lovestone, Simon, Nevado-Holgado, Alejo, Ribe, Elena, Vyas, Anviti, Winchester, Laura, Cleal, Madeleine, Gomez-Nicola, Diego, Mancuso, Renzo, Perry, Hugh, Cercignani, Mara, Clarke, Charlotte, Colasanti, Alessandro, Harrison, Neil, Murray, Rosemary, O'Connor, Jason, Mount, Howard, and Turkheimer, Federico E.
Abstract: Immune mechanisms have been implicated in the pathogenesis of depression. Translocator protein (TSPO)–targeted positron emission tomography (PET) has been used to assess neuroinflammation in major depressive disorder. We aimed to 1) test the hypothesis of significant case-control differences in TSPO binding in the anterior cingulate cortex, prefrontal cortex, and insula regions; and 2) explore the relationship between cerebral TSPO binding and peripheral blood C-reactive protein (CRP) concentration.
Published: 2021
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