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2. Contributors

Author

Anto, Aram, primary, Anto, Josep M, additional, Balli, Fabio, additional, Bedard, Annabelle, additional, Bedbrook, Anna, additional, Bousquet, Jean, additional, Brussino, Luisa, additional, Burgel, Pierre-Régis, additional, Burte, Emilie, additional, Camargo, Jr., Carlos A., additional, Canonica, G Walter, additional, Carr, Tara F., additional, Casale, Thomas, additional, Casas, Lidia, additional, Chassagnon, Guillaume, additional, Czarlewski, Wienczyslawa, additional, Dharmage, Shyamali C., additional, Dumas, Orianne, additional, Fonseca, Joao A, additional, Gaga, Mina, additional, Gemicioglu, Bilun, additional, Günther, Sven, additional, Habib, Stéfanie, additional, Hasegawa, Kohei, additional, Heinrich, Joachim, additional, Idrose, N. Sabrina, additional, Jacquemin, Bénédicte, additional, Klimek, Ludger, additional, Kvedariene, Violeta, additional, Leynaert, Bénédicte, additional, Li, Zhen, additional, Louis, Renaud, additional, Martin, Clémence, additional, Morin, Andréanne, additional, Moual, Nicole Le, additional, Nadif, Rachel, additional, Nagase, Hiroyuki, additional, Ober, Carole, additional, Pastré, Jean, additional, Patel, Sanjay B., additional, Puggioni, Francesca, additional, Real, Francisco Gómez, additional, Roche, Nicolas, additional, Sastre, Joaquin, additional, Savouré, Marine, additional, Schoettler, Nathan, additional, Scichilone, Nicola, additional, Sousa-Pinto, Bernardo, additional, Suzukawa, Maho, additional, Toivonen, Laura, additional, Valiulis, Arunas, additional, Varraso, Raphaëlle, additional, Yorgancioglu, Arzu, additional, Zervas, Eleptherios, additional, and Zuberbier, Torsten, additional

Published
2023
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3. Influence of exposure assessment methods on associations between long-term exposure to outdoor fine particulate matter and risk of cancer in the French cohort Gazel

Author

Lequy, Emeline, Zare Sakhvidi, Mohammad Javad, Vienneau, Danielle, de Hoogh, Kees, Chen, Jie, Dupuy, Jean-François, Garès, Valérie, Burte, Emilie, Bouaziz, Olivier, Le Tertre, Alain, Wagner, Vérène, Hertel, Ole, Christensen, Jesper Heile, Zhivin, Sergey, Siemiatycki, Jack, Goldberg, Marcel, Zins, Marie, and Jacquemin, Bénédicte

Published
2022
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4. Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

Author

Burte, Emilie, Leynaert, Bénédicte, Marcon, Alessandro, Bousquet, Jean, Benmerad, Meriem, Bono, Roberto, Carsin, Anne-Elie, de Hoogh, Kees, Forsberg, Bertil, Gormand, Frederic, Heinrich, Joachim, Just, Jocelyne, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Künzli, Nino, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, and Jacquemin, Bénédicte

Published
2020
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5. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author

Anto, Josep M., Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S., Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N., Lodrup Carlsen, Karin C., Koppelman, Gerard H., Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L., Maier, Dieter, Melén, Erik, Smit, Henriette A., Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M., Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C., Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J., Siroux, Valerie, Tischer, Christina G., Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian

Published
2017
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6. Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Author

Bousquet, Jean, Melén, Erik, Haahtela, Tari, Koppelman, Gerard, Togias, Alkis, Valenta, Rudolf, Akdis, Cezmi, Czarlewski, Wienczyslawa, Rothenberg, Marc, Valiulis, Arunas, Wickman, Magnus, Vichyanond, Pakit, Moniuszko, Marcin, Ėmužytė, Regina, Bush, Andrew, Chu, Derek K, Viegi, Giovanni, Wallace, Dana, Durham, Stephen, Wang, De Yun, Vandenplas, O., Just, Jocelyne, Carlsen, Karin C. Lodrup, Passalacqua, Giovanni, Williams, Siân, Linnemann, Désirée Larenas, Loureiro, Cláudia Chaves, Sagara, Hironori, Worm, Margitta, Yiallouros, Panayiotis, Yusuf, Osman, Zaitoun, Fares, Bonini, Matteo, Hrubiško, Martin, Cingi, C., Dykewicz, Mark, Zernotti, Mario, Calderon, Moises, Halpin, David M.G., Zidarn, Mihaela, Patella, Vincenzo, Sheikh, Aziz, Zuberbier, Jaron, Papadopoulos, Nikolaos, Louis, Renaud, Suppli Ulrik, Charlotte, Fonseca, João P., Zuberbier, Torsten, Anto, M. J., Costa, Elisio, Eiwegger, Thomas, Bosnic-Anticevich, Sinthia, Cruz, Alvaro, Sousa, Jaime Correia de, Louis-Philippe, Boulet, Erhola, Marina, Cardona, Victoria, Carr, Warner, Gemicioglu, Bilun, Pawankar, Ruby, Fokkens, Wytske, Calvo, Mário, Garcia-Aymerich, J., Mäkelä, Mika J., Hofmann, Maja Ann, Klimek, Ludger, Makris, Michael, Mohamed Sayed, Zeinab, Maurer, Marcus, D'Amato, G., Momas, Isabelle, Siroux, Valérie, Almeida, Mário Morais, Corrigan, Chris, Mullol, Joaquim, Montefort, Stephen, Jutel, Marek, Pham Thi, Nhan, Hossny, Elham, Akdis, Mubeccel, Pfaar, Oliver, Ventura, Maria Teresa, Regateiro, Frederico S., Bindslev-Jensen, Carsten, Ring, Johannes, Bustamante, Mariona, Pinto, Bernardo Sousa, Kaidashev, Igor, Guerra, Stefano, Standl, Marie, Sunyer, J., Keil, Thomas, Barata, Luís Taborda, Camargos, Paulo, Weiss, Scott, Naclerio, Robert, Yorgancıoglu, Arzu, Zhang, Luo, Nadeau, Kari, Abdul Latiff, Amir, Aberer, Werner, Heinrich, Joachim, Sisul, Juan, Nunes, Elizabete, Plavec, Davor, Agache, Ioana, Al-Ahmad, Mona, Serpa, Faradiba, Alobid, Isam, Kalayci, Omer, Giacco, S. Del, Fiocchi, Alessandro, Ansotegui Zubeldia, Ignacio Javier, Custovic, Adnan, Martins, Pedro Carreiro, Rouadi, Philip, Arshad, Syed Hasan, Asayag, Estrella, Bárbara, Cristina, Abdullah, Baharudin, Tomazic, Peter Valentin, Popov, T. A., Sayah, Zineb, Lkhagvaa, Battur, Nyembue Tshipukane , Dieudonne, Thomas, Mike, Bennoor, Kazi Saifuddin, Fyhrquist, Nanna Theresia, Irani, Carla, Berghea, Elena Camelia, De Blay, Frédéric, Toppila-Salmi, Sanna Katriina, Bergmann, Karl-Christian, Bernstein, D., Bewick, M., Casale, Thomas, Scheire, Sophie, Bumbacea, Roxana Silvia, Cepeda Sarabia, Alfonso, Puggioni, Francesca, Chandrasekharan, Ramanathan, Ohta, Ken, Okubo, Kimihiro, Charpin, Denis, Gomez, R Maximiliano, Chen, Y. Z., O'Hehir, Robyn, Cherrez Ojeda, Ivan, Bedbrook, Anna, To, Teresa, Devillier, Philippe, Schmid-Grendelmeier, Peter, Didier, Alain, Repka-Ramirez, María Susana, Teixeira, Maria Do Céu, Ispayeva, Zhanat, Dokic, Dejan, Quirce, Santiago, Douagui , Habib, Ivancevich, Juan Carlos, Gotua, Maia, Todo-Bom, Ana, Blain, Hubert, Guzman, Maria Antonieta, Kalyoncu, Ali Fuat, Hagemann, Jan, Buhl, Roland, Hamamah, Samir, Caraballo, Luis, Jares, Edgardo, Chivato, Tomás, Jartti, Tuomas, Jassem, Ewa, Christoff, George, Julge, Kalev, Ogulur, Ismail, Kardas, Przemyslaw, Doulaptsi, Maria, Kirenga, Bruce, Helga, Kraxner, Kull, Inger, Kulus, Marek, Daniel, Aguilar, Shamji, Mohamed, Kuna, Piotr, Nadif, Rachel, La Grutta, Stefania, Brightling, Chris, Samoliński, Bolesław, Lau, Susanne, Cordeiro, Carlos Manuel Da Silva Robalo, Solé, Dirceu, Le Thi Tuyet, Lan, Recto, Marysia, Ouedraogo, Solange, Halken, Susanne, Levin, Michael, Lipworth, Brian, Lourenço, Olga, Mahboub, Bassam, Niedoszytko, Marek, Sastre, Joaquin, Martinez‐Infante, E., Kupczyk, Maciej, Torres, María Jose, Matricardi, Paolo Maria, Cecchi, Lorenzo, Celedón, Juan C, Miculinic, Neven, Roche, Nicolas, Migueres, Nicolas, Brussino, Luisa, Florin, Mihaltan, Olze, Heidi, Savouré, Marine, Nekam, Kristof, Pali, Isabella, Okamoto, Yoshitaka, Palomares, O., Lemonnier, Nathanaël, Palosuo, Kati, Soto-Martinez, Manuel, Panaitescu, Carmen, Kvedarienė, Violeta, Panzner, P., Braido, Fulvio, Tsiligianni, Ioanna, Rodriguez-Gonzalez, Monica, Scichilone, Nicola, Canonica, Giogio Walter, Romantowski, Jan, Urrutia-Pereira, Marilyn, Filho, Nelson Augusto Rosario, Ollert, Markus W., Rottem, Menachem, Chkhartishvili, Ekaterine, Sova, Milan, Valovirta, Erkka, Mohammad, Yousser, Sperl, Annette, Spranger, Otto, Neffen, Hugo, Stelmach, Rafael, Burte, Emilie, Valentin Rostan, Marylin, Park, Hae-Sim, Van Ganse, Eric, Van Hage, Marianne, Pitsios, Constantinos, Vasankari, Tuula, and uBibliorum

Subjects
IL-33, Multimorbidity, Asthma, Toll-like receptors, Rhinitis
Abstract

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.

Published
2023

7. Outdoor air pollution and asthma in a changing climate

Author

Jacquemin, Bénédicte, Burte, Emilie, Savouré, Marine, Heinrich, Joachim, EHESP-Irset (EHESP-Irset), École des Hautes Études en Santé Publique [EHESP] (EHESP), Université de Rennes (UR), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, and Ludwig Maximilian University [Munich] (LMU)

Subjects
Particles, Epidemiology, [SDV]Life Sciences [q-bio], Allergies, Air pollution, Climate change, Pollen, Traffic, Gases, Asthma
Abstract

International audience; The purpose of the chapter is to summarize the recent research on the associations between long-term exposure to air pollution and asthma and allergies, both in adults and children, and to identify knowledge gaps for future research. The chapter also discusses the evidence of the impacts of climate change on air pollution as well as the possible interactions between air pollution, climate change, and allergens.

Published
2023
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12. Association between long-term ambient air pollution exposure and handgrip strength change in the French CONSTANCES cohort

Author

Burte, Emilie, primary, Zare Sakhvidi, Mohammad Javad, additional, Lafontaine, Antoine, additional, Lequy, Emeline, additional, Artaud, Fanny, additional, Berr, Claudine, additional, Canonico, Marianne, additional, Elbaz, Alexis, additional, de Hoogh, Kees, additional, Vienneau, Danielle, additional, Goldberg, Marcel, additional, Zins, Marie, additional, and Jacquemin, Bénédicte, additional

Published
2022
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14. Duration of nivolumab for pretreated, advanced non–small‐cell lung cancer

Author

Geier, Margaux, primary, Descourt, Renaud, additional, Corre, Romain, additional, Léveiller, Guillaume, additional, Lamy, Régine, additional, Goarant, Éric, additional, Bizec, Jean‐Louis, additional, Bernier, Cyril, additional, Quéré, Gilles, additional, Amrane, Karim, additional, Gaye, Elisabeth, additional, Lucia, François, additional, Burte, Emilie, additional, Chouaid, Christos, additional, and Robinet, Gilles, additional

Published
2020
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15. The Role of Socioeconomic Status in the Association of Lung Function and Air Pollution : A Pooled Analysis of Three Adult ESCAPE Cohorts

Author

Keidel, Dirk, Anto, Josep Maria, Basagaña, Xavier, Bono, Roberto, Burte, Emilie, Carsin, Anne-Elie, Forsberg, Bertil, Fuertes, Elaine, Galobardes, Bruna, Heinrich, Joachim, de Hoogh, Kees, Jarvis, Debbie, Künzli, Nino, Leynaert, Bénédicte, Marcon, Alessandro, Le Moual, Nicole, de Nazelle, Audrey, Schindler, Christian, Siroux, Valérie, Stempfelet, Morgane, Sunyer, Jordi, Temam, Sofia, Tsai, Ming-Yi, Varraso, Raphaëlle, Jacquemin, Bénédicte, Probst-Hensch, Nicole, Keidel, Dirk, Anto, Josep Maria, Basagaña, Xavier, Bono, Roberto, Burte, Emilie, Carsin, Anne-Elie, Forsberg, Bertil, Fuertes, Elaine, Galobardes, Bruna, Heinrich, Joachim, de Hoogh, Kees, Jarvis, Debbie, Künzli, Nino, Leynaert, Bénédicte, Marcon, Alessandro, Le Moual, Nicole, de Nazelle, Audrey, Schindler, Christian, Siroux, Valérie, Stempfelet, Morgane, Sunyer, Jordi, Temam, Sofia, Tsai, Ming-Yi, Varraso, Raphaëlle, Jacquemin, Bénédicte, and Probst-Hensch, Nicole

Abstract

Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated with both air pollution exposure and respiratory function. This study assesses the role of SES either as confounder or effect modifier of the association between ambient air pollution and lung function. Cross-sectional data from three European multicenter adult cohorts were pooled to assess factors associated with lung function, including annual means of home outdoor NO2. Pre-bronchodilator lung function was measured according to the ATS-criteria. Multiple mixed linear models with random intercepts for study areas were used. Three different factors (education, occupation and neighborhood unemployment rate) were considered to represent SES. NO2 exposure was negatively associated with lung function. Occupation and neighborhood unemployment rates were not associated with lung function. However, the inclusion of the SES-variable education improved the models and the air pollution-lung function associations got slightly stronger. NO2 associations with lung function were not substantially modified by SES-variables. In this multicenter European study we could show that SES plays a role as a confounder in the association of ambient NO2 exposure with lung function.

Published
2019
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16. The Role of Socioeconomic Status in the Association of Lung Function and Air Pollution—A Pooled Analysis of Three Adult ESCAPE Cohorts

Author

Keidel, Dirk, primary, Anto, Josep Maria, additional, Basagaña, Xavier, additional, Bono, Roberto, additional, Burte, Emilie, additional, Carsin, Anne-Elie, additional, Forsberg, Bertil, additional, Fuertes, Elaine, additional, Galobardes, Bruna, additional, Heinrich, Joachim, additional, de Hoogh, Kees, additional, Jarvis, Debbie, additional, Künzli, Nino, additional, Leynaert, Bénédicte, additional, Marcon, Alessandro, additional, Le Moual, Nicole, additional, de Nazelle, Audrey, additional, Schindler, Christian, additional, Siroux, Valérie, additional, Stempfelet, Morgane, additional, Sunyer, Jordi, additional, Temam, Sofia, additional, Tsai, Ming-Yi, additional, Varraso, Raphaëlle, additional, Jacquemin, Bénédicte, additional, and Probst-Hensch, Nicole, additional

Published
2019
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17. Association between air pollution and rhinitis incidence in two European cohorts

Author

Burte, Emilie, Leynaert, Bénédicte, Bono, Roberto, Brunekreef, Bert, Bousquet, Jean, Carsin, Anne-Elie, De Hoogh, Kees, Forsberg, Bertil, Gormand, Frédéric, Heinrich, Joachim, Just, Jocelyne, Marcon, Alessandro, Künzli, Nino, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, Jacquemin, Bénédicte, Burte, Emilie, Leynaert, Bénédicte, Bono, Roberto, Brunekreef, Bert, Bousquet, Jean, Carsin, Anne-Elie, De Hoogh, Kees, Forsberg, Bertil, Gormand, Frédéric, Heinrich, Joachim, Just, Jocelyne, Marcon, Alessandro, Künzli, Nino, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, and Jacquemin, Bénédicte

Abstract

The association between air pollution and rhinitis is not well established. Aim: The aim of this longitudinal analysis was to study the association between modeled air pollution at the subjects' home addresses and self-reported incidence of rhinitis. Methods: We used data from 1533 adults from two multicentre cohorts' studies (EGEA and ECRHS). Rhinitis incidence was defined as reporting rhinitis at the second follow-up (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the ESCAPE project for the 2009-2010 period. Incidence rate ratios (IRR) were computed using Poisson regression. Pooled analysis, analyses by city and meta-regression testing for heterogeneity were carried out. Results: No association between long-term air pollution exposure and incidence of rhinitis was found (adjusted IRR (aIRR) for an increase of 10 mu g center dot m(-3) of NO2: 1.00 [0.91-1.09], for an increase of 5 mu g center dot m(-3) of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10 mu g center dot m(-3) of NO2: 1.01 [0.87-1.17], for an increase of 5 mu g center dot m(-3) of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional pattern emerged for any of the pollutants. Conclusions: This study did not find any consistent evidence of an association between long-term air pollution and incident rhinitis.

Published
2018
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18. Association between air pollution and rhinitis incidence in two European cohorts

Author

One Health Chemisch, dIRAS RA-2, Burte, Emilie, Leynaert, Bénédicte, Bono, Roberto, Brunekreef, Bert, Bousquet, Jean, Carsin, Anne-Elie, De Hoogh, Kees, Forsberg, Bertil, Gormand, Frédéric, Heinrich, Joachim, Just, Jocelyne, Marcon, Alessandro, Künzli, Nino, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, Jacquemin, Bénédicte, One Health Chemisch, dIRAS RA-2, Burte, Emilie, Leynaert, Bénédicte, Bono, Roberto, Brunekreef, Bert, Bousquet, Jean, Carsin, Anne-Elie, De Hoogh, Kees, Forsberg, Bertil, Gormand, Frédéric, Heinrich, Joachim, Just, Jocelyne, Marcon, Alessandro, Künzli, Nino, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, and Jacquemin, Bénédicte

Published
2018

19. Association between air pollution and rhinitis incidence in two European cohorts

Author

Burte, Emilie, Leynaert, Bénédicte, Bono, Roberto, Brunekreef, Bert, Bousquet, Jean, Carsin, Anne-Elie, De Hoogh, Kees, Forsberg, Bertil, Gormand, Frédéric, Heinrich, Joachim, Just, Jocelyne, Marcon, Alessandro, Künzli, Nino, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, Jacquemin, Bénédicte, One Health Chemisch, dIRAS RA-2, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology & Pulmonology [Barcelona, Spain] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF)-Centre de Recerca en Epidemiologia Ambiental - CREAL [Barcelona, Spain]-Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Public Health and Pediatrics [Turin, Italy], University of Turin, Institute for Risk Assessment Sciences [Utrecht, The Netherlands] (IRAS), Utrecht University [Utrecht], Julius Center for Health Sciences and Primary Care [Utrecht, The Netherlands], University Medical Center [Utrecht], Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIBER de Epidemiología y Salud Pública (CIBERESP), Hospital del Mar Medical Research Institute [Barcelona, Spain] (IMIM), Universitat Pompeu Fabra [Barcelona] (UPF), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Department of Public Health and Clinical Medicine [Umeå, Sweden] (Environmental and Occupational Medicine), Umeå University, Service de pneumologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Social and Environmental Medicine [Munich, Germany] (Institute and Outpatient Clinic for Occupational), Ludwig-Maximilians University [Munich] (LMU)-University Hospital Munich [Munich, Germany], Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Diagnostics and Public Health [Verona] (UNIVR | DDSP), University of Verona (UNIVR), Unit of Epidemiology and Medical Statistics [Verona, Italy] (Dept of Diagnostics and Public Health), Service de pédiatrie générale et maladies infectieuses [CHU Grenoble], CHU Grenoble, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Veille Sanitaire (INVS), Unit of Biostatistics and Clinical Epidemiology [Pavia, Italy] (Dept of Public Health), University of Pavia-Experimental and Forensic Medicine [Pavia, Italy], School of Public Health [London, UK] (Faculty of Medicine), Imperial College London, Medical Research Council (MRC), One Health Chemisch, dIRAS RA-2, Università degli studi di Torino = University of Turin (UNITO), Ludwig-Maximilians-Universität München (LMU)-University Hospital Munich [Munich, Germany], Università degli studi di Verona = University of Verona (UNIVR), Università degli Studi di Pavia = University of Pavia (UNIPV)-Experimental and Forensic Medicine [Pavia, Italy], and Faraldo, Beatrice

Subjects
medicine.medical_specialty, Air pollution, MEDLINE, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Environmental health, air pollution, rhinitis, epidemiology, Air Pollution, Epidemiology, MD Multidisciplinary, medicine, Humans, lcsh:Environmental sciences, 0105 earth and related environmental sciences, General Environmental Science, Retrospective Studies, Rhinitis, lcsh:GE1-350, Air Pollutants, business.industry, Incidence (epidemiology), Incidence, Retrospective cohort study, 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 13. Climate action, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Environmental Sciences
Abstract

International audience; BACKGROUND:The association between air pollution and rhinitis is not well established.AIM:The aim of this longitudinal analysis was to study the association between modeled air pollution at the subjects' home addresses and self-reported incidence of rhinitis.METHODS:We used data from 1533 adults from two multicentre cohorts' studies (EGEA and ECRHS). Rhinitis incidence was defined as reporting rhinitis at the second follow-up (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the ESCAPE project for the 2009-2010 period. Incidence rate ratios (IRR) were computed using Poisson regression. Pooled analysis, analyses by city and meta-regression testing for heterogeneity were carried out.RESULTS:No association between long-term air pollution exposure and incidence of rhinitis was found (adjusted IRR (aIRR) for an increase of 10 μg·m-3 of NO2: 1.00 [0.91-1.09], for an increase of 5 μg·m-3 of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10 μg·m-3 of NO2: 1.01 [0.87-1.17], for an increase of 5 μg·m-3 of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional pattern emerged for any of the pollutants.CONCLUSIONS:This study did not find any consistent evidence of an association between long-term air pollution and incident rhinitis.

Published
2017
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20. Association between air pollution and rhinitis incidence in two European cohorts

Author

Burte, Emilie, primary, Leynaert, Bénédicte, additional, Bono, Roberto, additional, Brunekreef, Bert, additional, Bousquet, Jean, additional, Carsin, Anne-Elie, additional, De Hoogh, Kees, additional, Forsberg, Bertil, additional, Gormand, Frédéric, additional, Heinrich, Joachim, additional, Just, Jocelyne, additional, Marcon, Alessandro, additional, Künzli, Nino, additional, Nieuwenhuijsen, Mark, additional, Pin, Isabelle, additional, Stempfelet, Morgane, additional, Sunyer, Jordi, additional, Villani, Simona, additional, Siroux, Valérie, additional, Jarvis, Deborah, additional, Nadif, Rachel, additional, and Jacquemin, Bénédicte, additional

Published
2018
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22. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author

Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian

Abstract

Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non-IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. A microarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), and transcriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4 years and 11,080 children aged 8 years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.

Published
2017

23. Socioeconomic position and outdoor nitrogen dioxide (NO2) exposure in Western Europe: A multi-city analysis

Author

Temam, Sofia, Burte, Emilie, Adam, Martin, Antó, Josep M, Basagaña, Xavier, Bousquet, Jean, Carsin, Anne-Elie, Galobardes, Bruna, Keidel, Dirk, Künzli, Nino, Le Moual, Nicole, Sanchez, Margaux, Sunyer, Jordi, Bono, Roberto, Brunekreef, Bert, Heinrich, Joachim, de Hoogh, Kees, Jarvis, Debbie, Marcon, Alessandro, Modig, Lars, Nadif, Rachel, Nieuwenhuijsen, Mark, Pin, Isabelle, Siroux, Valérie, Stempfelet, Morgane, Tsai, Ming-Yi, Probst-Hensch, Nicole, Jacquemin, Bénédicte, Temam, Sofia, Burte, Emilie, Adam, Martin, Antó, Josep M, Basagaña, Xavier, Bousquet, Jean, Carsin, Anne-Elie, Galobardes, Bruna, Keidel, Dirk, Künzli, Nino, Le Moual, Nicole, Sanchez, Margaux, Sunyer, Jordi, Bono, Roberto, Brunekreef, Bert, Heinrich, Joachim, de Hoogh, Kees, Jarvis, Debbie, Marcon, Alessandro, Modig, Lars, Nadif, Rachel, Nieuwenhuijsen, Mark, Pin, Isabelle, Siroux, Valérie, Stempfelet, Morgane, Tsai, Ming-Yi, Probst-Hensch, Nicole, and Jacquemin, Bénédicte

Abstract

BACKGROUND: Inconsistent associations between socioeconomic position (SEP) and outdoor air pollution have been reported in Europe, but methodological differences prevent any direct between-study comparison.OBJECTIVES: Assess and compare the association between SEP and outdoor nitrogen dioxide (NO2) exposure as a marker of traffic exhaust, in 16 cities from eight Western European countries.METHODS: Three SEP indicators, two defined at individual-level (education and occupation) and one at neighborhood-level (unemployment rate) were assessed in three European multicenter cohorts. NO2 annual concentration exposure was estimated at participants' addresses with land use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE; http://www.escapeproject.eu/). Pooled and city-specific linear regressions were used to analyze associations between each SEP indicator and NO2. Heterogeneity across cities was assessed using the Higgins' I-squared test (I(2)).RESULTS: The study population included 5692 participants. Pooled analysis showed that participants with lower individual-SEP were less exposed to NO2. Conversely, participants living in neighborhoods with higher unemployment rate were more exposed. City-specific results exhibited strong heterogeneity (I(2)>76% for the three SEP indicators) resulting in variation of the individual- and neighborhood-SEP patterns of NO2 exposure across cities. The coefficients from a model that included both individual- and neighborhood-SEP indicators were similar to the unadjusted coefficients, suggesting independent associations.CONCLUSIONS: Our study showed for the first time using homogenized measures of outcome and exposure across 16 cities the important heterogeneity regarding the association between SEP and NO2 in Western Europe. Importantly, our results showed that individual- and neighborhood-SEP indicators capture different aspects of the association between SE

Published
2017

24. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author

dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian

Published
2017

25. Socioeconomic position and outdoor nitrogen dioxide (NO2) exposure in Western Europe: A multi-city analysis

Author

dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Temam, Sofia, Burte, Emilie, Adam, Martin, Antó, Josep M, Basagaña, Xavier, Bousquet, Jean, Carsin, Anne-Elie, Galobardes, Bruna, Keidel, Dirk, Künzli, Nino, Le Moual, Nicole, Sanchez, Margaux, Sunyer, Jordi, Bono, Roberto, Brunekreef, Bert, Heinrich, Joachim, de Hoogh, Kees, Jarvis, Debbie, Marcon, Alessandro, Modig, Lars, Nadif, Rachel, Nieuwenhuijsen, Mark, Pin, Isabelle, Siroux, Valérie, Stempfelet, Morgane, Tsai, Ming-Yi, Probst-Hensch, Nicole, Jacquemin, Bénédicte, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Temam, Sofia, Burte, Emilie, Adam, Martin, Antó, Josep M, Basagaña, Xavier, Bousquet, Jean, Carsin, Anne-Elie, Galobardes, Bruna, Keidel, Dirk, Künzli, Nino, Le Moual, Nicole, Sanchez, Margaux, Sunyer, Jordi, Bono, Roberto, Brunekreef, Bert, Heinrich, Joachim, de Hoogh, Kees, Jarvis, Debbie, Marcon, Alessandro, Modig, Lars, Nadif, Rachel, Nieuwenhuijsen, Mark, Pin, Isabelle, Siroux, Valérie, Stempfelet, Morgane, Tsai, Ming-Yi, Probst-Hensch, Nicole, and Jacquemin, Bénédicte

Published
2017

26. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author

Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Other research (not in main researchprogram), Epi Infectieziekten Team 3, Infection & Immunity, Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Other research (not in main researchprogram), Epi Infectieziekten Team 3, Infection & Immunity, Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian

Published
2017

27. Socioeconomic position and outdoor nitrogen dioxide (NO2) exposure in Western Europe: A multi-city analysis

Author

Temam, Sofia, primary, Burte, Emilie, additional, Adam, Martin, additional, Antó, Josep M., additional, Basagaña, Xavier, additional, Bousquet, Jean, additional, Carsin, Anne-Elie, additional, Galobardes, Bruna, additional, Keidel, Dirk, additional, Künzli, Nino, additional, Le Moual, Nicole, additional, Sanchez, Margaux, additional, Sunyer, Jordi, additional, Bono, Roberto, additional, Brunekreef, Bert, additional, Heinrich, Joachim, additional, de Hoogh, Kees, additional, Jarvis, Debbie, additional, Marcon, Alessandro, additional, Modig, Lars, additional, Nadif, Rachel, additional, Nieuwenhuijsen, Mark, additional, Pin, Isabelle, additional, Siroux, Valérie, additional, Stempfelet, Morgane, additional, Tsai, Ming-Yi, additional, Probst-Hensch, Nicole, additional, and Jacquemin, Bénédicte, additional

Published
2017
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28. Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study

Author

Burte, Emilie, Bousquet, Jean, Varraso, Raphaëlle, Gormand, Frédéric, Just, Jocelyne, Matran, Régis, Pin, Isabelle, Siroux, Valerie, Jacquemin, Bénédicte, Nadif, Rachel, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Department of Pneumology [Lyon], Hospices Civils de Lyon (HCL), Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Université Lille Nord de France (COMUE), Team of environmental epidemiology applied to reproduction and respiratory health / IAB, INSERM, CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Pediatric department, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and HAL UPMC, Gestionnaire

Subjects
Adult, Male, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, lcsh:R, lcsh:Medicine, Comorbidity, Allergens, Asthma, respiratory tract diseases, Cross-Sectional Studies, Phenotype, immune system diseases, Case-Control Studies, Surveys and Questionnaires, Prevalence, Humans, Female, lcsh:Q, France, Self Report, lcsh:Science, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Rhinitis, Research Article
Abstract

International audience; BackgroundThe classification of rhinitis in adults is missing in epidemiological studies.ObjectiveTo identify phenotypes of adult rhinitis using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach.Methods983 adults of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) were studied. Self-reported symptoms related to rhinitis such as nasal symptoms, hay fever, sinusitis, conjunctivitis, and sensitivities to different triggers (dust, animals, hay/flowers, cold air…) were used. Allergic sensitization was defined by at least one positive skin prick test to 12 aeroallergens. Mixture model was used to cluster participants, independently in those without (Asthma-, n = 582) and with asthma (Asthma+, n = 401).ResultsThree clusters were identified in both groups: 1) Cluster A (55% in Asthma-, and 22% in Asthma+) mainly characterized by the absence of nasal symptoms, 2) Cluster B (23% in Asthma-, 36% in Asthma+) mainly characterized by nasal symptoms all over the year, sinusitis and a low prevalence of positive skin prick tests, and 3) Cluster C (22% in Asthma-, 42% in Asthma+) mainly characterized by a peak of nasal symptoms during spring, a high prevalence of positive skin prick tests and a high report of hay fever, allergic rhinitis and conjunctivitis. The highest rate of polysensitization (80%) was found in participants with comorbid asthma and allergic rhinitis.ConclusionThis cluster analysis highlighted three clusters of rhinitis with similar characteristics than those known by clinicians but differing according to allergic sensitization, and this whatever the asthma status. These clusters could be easily rebuilt using a small number of variables.

Published
2015
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29. Socioeconomic position and air pollution exposure in Western Europe: A multi-city analysis

Author

Jacquemin*, Bénédicte, primary, Temam, Sofia, additional, Burte, Emilie, additional, Adam, Martin, additional, Anto, Josep Maria, additional, Basagaña, Xavier, additional, Bousquet, Jean, additional, Carsin, Anne Elie, additional, Galobardes, Bruna, additional, Jarvis, Debie, additional, Keidel, Dirk, additional, Künzli, Nino, additional, Moual, Nicole Le, additional, Sunyer, Jordi, additional, and Probst-Hensch, Nicole, additional

Published
2016
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32. P I – 1–5 Association between air pollution and severity of rhinitis in two european cohorts

Author

Burte, Emilie, Leynaert, Bénéédicte, Kunzli, Nino, Siroux, Valééérie, Jarvis, Deborah, Nadif, Rachel, and Jacquemin, Béééénééééédicte

Abstract

Background/aimLittle is known about the effects of outdoor air pollution on severity of rhinitis. The objective is to assess the association between modelled PM10, PM2.5and NO2concentrations and severity of rhinitis in two multicenter European cohorts on respiratory health (EGEA and ECRHS).Methods1603 adults with data on air pollution and on severity of at least one rhinitis symptom were included. Annual exposure to NO2, PM10and PM2.5was estimated at participants’ residential address using land use regression models thanks to the ESCAPE project. Severity of rhinitis was defined in two ways:according to the importance of the disturbance due to four symptoms of rhinitis (runny nose, blocked nose, sneezing and itchy nose) categorised in 3 groups: no (reference), mild or high severity,using an overall score of severity including disturbances to all symptoms, varying from 0 to 12.Polytomous logistic or linear regression was used, and the city was further included as a random effect. Adjusted odds ratio are presented for an increase of 10 µg.m−3of NO2and 5 µg.m−3of PM2.5.ResultsThe 1603 adults (mean age=52.5 years, 45% men, 73% from ECRHS) from 17 cities had a median[Q1-Q3] score of severity of 4[2–6]. Exposure to air pollution was associated with an increased score of severity of rhinitis (aOR[95% CI] for NO2: 1.13 [1.03–1.25], for PM2.5: 1.85 [1.47–2.33]). Exposure to NO2was also associated with an increased severity of blocked nose (aOR for NO2: 1.17 [1.06–1.30] for mild and 1.21 [1.10–1.33] for high severity) and similarly with runny nose, but not with itchy nose or sneezing. Exposure to PM2.5or PM10was associated with mild severity for blocked nose and with high severity for all symptoms (aOR for blocked nose for PM2.5: 1.41 [1.06–1.88] for mild and 1.91 [1.46–2.51] for high severity). Similar results were found when considering city as a random effect.ConclusionSeverity of rhinitis and particularly blocked nose symptoms are associated with air pollution exposure.

Published
2018
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33. Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes

Author

Isabelle Pin, Stefano Guerra, Cynthia Hohmann, Marit Westman, Mariona Pinart, Jordi Mestres, Martijn C. Nawijn, Tari Haahtela, Dirkje S. Postma, Torsten Zuberbier, Kalus Wenzel, Mika J. Mäkelä, Fanny Rancière, Karin C. Lødrup Carlsen, Mirela Curin, Dieter Maier, Stephane Ballereau, Johan Pellet, Cezmi A. Akdis, Claus Bachert, Erik Melén, Emilie Burte, Bénédicte Jacquemin, Jean Bousquet, Anne Cambon-Thomsen, Christian Lupinek, I. Skrindo, Mübeccel Akdis, Rachel Nadif, Bert Brunekreef, Judith Garcia-Aymerich, Jonathan M. Coquet, Valérie Siroux, Inger Kull, Peter Mowinckel, Bart N. Lambrecht, Renata Kiss, Anna Bedbrook, Ferran Ballester, Kai-Håkon Carlsen, Yvan Saeys, Raphaëlle Varraso, Emmanuelle Rial-Sebbag, Giuseppe De Carlo, Sibylle Koletzko, Maria Pia Fantini, Joachim Heinrich, Jordi Sunyer, Andrea von Berg, Gerard H. Koppelman, Theresa Keller, Vergard Hovland, John Wright, Nicolas Lemonnier, Josep M. Antó, Marta Benet, Rudolf Valenta, Irina Lehmann, Susanne Lau, Francesco Forastiere, Isabelle Momas, Niklas Andersson, Albert Arno, Pascal Demoly, Jocelyne Just, Anna Bergström, Charles Auffray, Henriette A. Smit, Delphine Smagghe, Manolis Kogevinas, Anna Asarnoj, Marie Standl, Daniela Porta, I. Annesi-Maesano, Martijn J. Schuijs, Ulrike Gehring, Mathies Torrent, Thomas Keil, Christina Tischer, Cheng-Jian Xu, Esben Eller, Marek L. Kowalski, Carsten Bindslev-Jensen, Leda Chatzi, Magnus Wickman, Natalia Ballardini, Leena von Hertzen, Xavier Basagaña, Anto, Josep M., Bousquet, Jean, Akdis, Mubeccel, Auffray, Charle, Keil, Thoma, Momas, Isabelle, Postma, Dirkje S., Valenta, Rudolf, Wickman, Magnu, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N., Lodrup Carlsen, Karin C., Koppelman, Gerard H., Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L., Maier, Dieter, Melén, Erik, Smit, Henriette A., Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Nikla, Bachert, Clau, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M., Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manoli, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicola, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C., Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J., Siroux, Valerie, Tischer, Christina G., Torrent, Mathie, Varraso, Raphaelle, Wenzel, Kalu, Xu, Cheng-Jian, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), European Institute for Systems Biology and Medicine (EISBM), Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins (DS3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut Albert Bonniot, Département de pédiatrie, CHU Grenoble-Hôpital Michallon, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
0301 basic medicine, Allergy, Genome-wide association study, Comorbidity, Immunoglobulin E, medicine.disease_cause, Cohort Studies, Translational Research, Biomedical, 0302 clinical medicine, Allergen, REGULATORY B-CELLS, PRECISION MEDICINE, Medicine, BIRTH COHORT INFANTS, ATOPIC-DERMATITIS, Immunology and Allergy, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, Child, media_common, biology, atopic dermatitis, Atopic dermatitis, 3. Good health, Europe, Multicenter Study, CHRONIC RESPIRATORY-DISEASES, rhiniti, Phenotype, INNER-CITY CHILDREN, Biomarker (medicine), Female, atopic dermatiti, Adolescent, EUROPEAN INNOVATION PARTNERSHIP, Immunology, review, 03 medical and health sciences, EARLY-LIFE, Young Adult, rhinitis, Asthma, Atopic Dermatitis, Rhinitis, Hypersensitivity, Journal Article, media_common.cataloged_instance, Animals, Humans, European union, MOUNTAIN CEDAR POLLINOSIS, business.industry, Gene Expression Profiling, CHILDHOOD ASTHMA, Allergens, medicine.disease, allergy, 030104 developmental biology, 030228 respiratory system, biology.protein, Immunization, business, Genome-Wide Association Study
Abstract

Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including invivo and invitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. Amicroarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), andtranscriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4years and 11,080 children aged 8years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.

Published
2017
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34. Socioeconomic position and outdoor nitrogen dioxide (NO 2 ) exposure in Western Europe: A multi-city analysis.

Author

Temam S, Burte E, Adam M, Antó JM, Basagaña X, Bousquet J, Carsin AE, Galobardes B, Keidel D, Künzli N, Le Moual N, Sanchez M, Sunyer J, Bono R, Brunekreef B, Heinrich J, de Hoogh K, Jarvis D, Marcon A, Modig L, Nadif R, Nieuwenhuijsen M, Pin I, Siroux V, Stempfelet M, Tsai MY, Probst-Hensch N, and Jacquemin B

Subjects
Adult, Air Pollution analysis, Bronchiolitis etiology, Cities, Cross-Sectional Studies, Environmental Exposure adverse effects, Europe epidemiology, Female, Humans, Linear Models, Male, Middle Aged, Occupations, Socioeconomic Factors, Air Pollutants analysis, Bronchiolitis epidemiology, Nitrogen Dioxide analysis, Vehicle Emissions analysis
Abstract

Background: Inconsistent associations between socioeconomic position (SEP) and outdoor air pollution have been reported in Europe, but methodological differences prevent any direct between-study comparison., Objectives: Assess and compare the association between SEP and outdoor nitrogen dioxide (NO 2 ) exposure as a marker of traffic exhaust, in 16 cities from eight Western European countries., Methods: Three SEP indicators, two defined at individual-level (education and occupation) and one at neighborhood-level (unemployment rate) were assessed in three European multicenter cohorts. NO 2 annual concentration exposure was estimated at participants' addresses with land use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE; http://www.escapeproject.eu/). Pooled and city-specific linear regressions were used to analyze associations between each SEP indicator and NO 2 . Heterogeneity across cities was assessed using the Higgins' I-squared test (I 2 )., Results: The study population included 5692 participants. Pooled analysis showed that participants with lower individual-SEP were less exposed to NO 2 . Conversely, participants living in neighborhoods with higher unemployment rate were more exposed. City-specific results exhibited strong heterogeneity (I 2 >76% for the three SEP indicators) resulting in variation of the individual- and neighborhood-SEP patterns of NO 2 exposure across cities. The coefficients from a model that included both individual- and neighborhood-SEP indicators were similar to the unadjusted coefficients, suggesting independent associations., Conclusions: Our study showed for the first time using homogenized measures of outcome and exposure across 16 cities the important heterogeneity regarding the association between SEP and NO 2 in Western Europe. Importantly, our results showed that individual- and neighborhood-SEP indicators capture different aspects of the association between SEP and exposure to air pollution, stressing the importance of considering both in air pollution health effects studies., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Published
2017
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