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3. Breast cancer differential diagnosis using diffuse optical spectroscopic imaging and regression with z-score normalized data.

Author

Cochran, Jeffrey M, Leproux, Anais, Busch, David R, O'Sullivan, Thomas D, Yang, Wei, Mehta, Rita S, Police, Alice M, Tromberg, Bruce J, and Yodh, Arjun G

Subjects
Breast, Humans, Breast Neoplasms, Diagnosis, Differential, Mammography, Spectrum Analysis, Retrospective Studies, Female, biopsy, breast cancer, differential diagnosis, diffuse optics, Clinical Research, Breast Cancer, Bioengineering, Cancer, Biomedical Imaging, 4.2 Evaluation of markers and technologies, 4.1 Discovery and preclinical testing of markers and technologies, Optics, Optical Physics, Biomedical Engineering, Opthalmology and Optometry
Abstract

SignificanceCurrent imaging paradigms for differential diagnosis of suspicious breast lesions suffer from high false positive rates that force patients to undergo unnecessary biopsies. Diffuse optical spectroscopic imaging (DOSI) noninvasively probes functional hemodynamic and compositional parameters in deep tissue and has been shown to be sensitive to contrast between normal and malignant tissues.AimDOSI methods are under investigation as an adjunct to mammography and ultrasound that could reduce false positive rates and unnecessary biopsies, particularly in radiographically dense breasts.MethodsWe performed a retrospective analysis of 212 subjects with suspicious breast lesions who underwent DOSI imaging. Physiological tissue parameters were z-score normalized to the patient's contralateral breast tissue and input to univariate logistic regression models to discriminate between malignant tumors and the surrounding normal tissue. The models were then used to differentiate malignant lesions from benign lesions.ResultsModels incorporating several individual hemodynamic parameters were able to accurately distinguish malignant tumors from both the surrounding background tissue and benign lesions with area under the curve (AUC) ≥0.85. Z-score normalization improved the discriminatory ability and calibration of these predictive models relative to unnormalized or ratio-normalized data.ConclusionsFindings from a large subject population study show how DOSI data normalization that accounts for normal tissue heterogeneity and quantitative statistical regression approaches can be combined to improve the ability of DOSI to diagnose malignant lesions. This improved diagnostic accuracy, combined with the modality's inherent logistical advantages of portability, low cost, and nonionizing radiation, could position DOSI as an effective adjunct modality that could be used to reduce the number of unnecessary invasive biopsies.

Published
2021

7. Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine

Author

Padawer-Curry, Jonah A., Volk, Lindsay E., Mavroudis, Constantine D., Ko, Tiffany S., Morano, Vincent C., Busch, David R., Rosenthal, Tami M., Melchior, Richard W., Shade, Brandon C., Schiavo, Kellie L., Boorady, Timothy W., Schmidt, Alexander L., Andersen, Kristen N., Breimann, Jake S., Jahnavi, Jharna, Mensah-Brown, Kobina G., Yodh, Arjun G., Mascio, Christopher E., Kilbaugh, Todd J., Licht, Daniel J., White, Brian R., and Baker, Wesley B.

Published
2022
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9. Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment

Author

Cochran, Jeffrey M, Busch, David R, Leproux, Anaïs, Zhang, Zheng, O’Sullivan, Thomas D, Cerussi, Albert E, Carpenter, Philip M, Mehta, Rita S, Roblyer, Darren, Yang, Wei, Paulsen, Keith D, Pogue, Brian, Jiang, Shudong, Kaufman, Peter A, Chung, So Hyun, Schnall, Mitchell, Snyder, Bradley S, Hylton, Nola, Carp, Stefan A, Isakoff, Steven J, Mankoff, David, Tromberg, Bruce J, and Yodh, Arjun G

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Women's Health, Cancer, Biomedical Imaging, Clinical Research, 4.1 Discovery and preclinical testing of markers and technologies, 6.1 Pharmaceuticals, Adult, Antineoplastic Agents, Biomarkers, Breast Neoplasms, Chemotherapy, Adjuvant, Female, Humans, Logistic Models, Middle Aged, Neoadjuvant Therapy, Oxygen Consumption, Point-of-Care Testing, ROC Curve, Spectroscopy, Near-Infrared, Survival Analysis, biomedical optics, neoadjuvant chemotherapy, diffuse optical spectroscopy, breast cancer, therapy monitoring, translational imaging, Optical Physics, Biomedical Engineering, Opthalmology and Optometry, Optics, Ophthalmology and optometry, Biomedical engineering, Atomic, molecular and optical physics
Abstract

Ideally, neoadjuvant chemotherapy (NAC) assessment should predict pathologic complete response (pCR), a surrogate clinical endpoint for 5-year survival, as early as possible during typical 3- to 6-month breast cancer treatments. We introduce and demonstrate an approach for predicting pCR within 10 days of initiating NAC. The method uses a bedside diffuse optical spectroscopic imaging (DOSI) technology and logistic regression modeling. Tumor and normal tissue physiological properties were measured longitudinally throughout the course of NAC in 33 patients enrolled in the American College of Radiology Imaging Network multicenter breast cancer DOSI trial (ACRIN-6691). An image analysis scheme, employing z-score normalization to healthy tissue, produced models with robust predictions. Notably, logistic regression based on z-score normalization using only tissue oxygen saturation (StO2) measured within 10 days of the initial therapy dose was found to be a significant predictor of pCR (AUC  =  0.92; 95% CI: 0.82 to 1). This observation suggests that patients who show rapid convergence of tumor tissue StO2 to surrounding tissue StO2 are more likely to achieve pCR. This early predictor of pCR occurs prior to reductions in tumor size and could enable dynamic feedback for optimization of chemotherapy strategies in breast cancer.

Published
2018

11. Wavelet and time-based cerebral autoregulation analysis using diffuse correlation spectroscopy on adults undergoing extracorporeal membrane oxygenation therapy.

Author

Dar, Irfaan A., Khan, Imad R., Johnson, Thomas W., Helmy, Samantha Marie, Cardona, Jeronimo I., Escobar, Samantha, Selioutski, Olga, Marinescu, Mark A., Zhang, Chloe T., Proctor, Ashley R., AbdAllah, Noura, Busch, David R., Maddox, Ross K., and Choe, Regine

Subjects
EXTRACORPOREAL membrane oxygenation, PEARSON correlation (Statistics), BRAIN tomography, CARDIOPULMONARY bypass, WAVELETS (Mathematics), CEREBRAL circulation
Abstract

Introduction: Adult patients who have suffered acute cardiac or pulmonary failure are increasingly being treated using extracorporeal membrane oxygenation (ECMO), a cardiopulmonary bypass technique. While ECMO has improved the long-term outcomes of these patients, neurological injuries can occur from underlying illness or ECMO itself. Cerebral autoregulation (CA) allows the brain to maintain steady perfusion during changes in systemic blood pressure. Dysfunctional CA is a marker of acute brain injury and can worsen neurologic damage. Monitoring CA using invasive modalities can be risky in ECMO patients due to the necessity of anticoagulation therapy. Diffuse correlation spectroscopy (DCS) measures cerebral blood flow continuously, noninvasively, at the bedside, and can monitor CA. In this study, we compare DCS-based markers of CA in veno-arterial ECMO patients with and without acute brain injury. Methods: Adults undergoing ECMO were prospectively enrolled at a single tertiary hospital and underwent DCS and arterial blood pressure monitoring during ECMO. Neurologic injuries were identified using brain computerized tomography (CT) scans obtained in all patients. CA was calculated over a twenty-minute window via wavelet coherence analysis (WCA) over 0.05 Hz to 0.1 Hz and a Pearson correlation (DCSx) between cerebral blood flow measured by DCS and mean arterial pressure. Results: Eleven ECMO patients who received CT neuroimaging were recruited. 5 (45%) patients were found to have neurologic injury. CA indices WCOH, the area under the curve of the WCA, were significantly higher for patients with neurological injuries compared to those without neurological injuries (right hemisphere p = 0.041, left hemisphere p = 0.041). %DCSx, percentage of time DCSx was above a threshold 0.4, were not significantly higher (right hemisphere p = 0.268, left hemisphere p = 0.073). Conclusion: DCS can be used to detect differences in CA for ECMO patients with neurological injuries compared to uninjured patients using WCA. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease

Author

Gregori-Pla, Clara, Mesquita, Rickson C., Favilla, Christopher G., Busch, David R., Blanco, Igor, Zirak, Peyman, Frisk, Lisa Kobayashi, Avtzi, Stella, Maruccia, Federica, Giacalone, Giacomo, Cotta, Gianluca, Camps-Renom, Pol, Mullen, Michael T., Martí-Fàbregas, Joan, Prats-Sánchez, Luís, Martínez-Domeño, Alejandro, Kasner, Scott E., Greenberg, Joel H., Zhou, Chao, Edlow, Brian L., Putt, Mary E., Detre, John A., Yodh, Arjun G., Durduran, Turgut, and Delgado-Mederos, Raquel

Published
2021
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15. Neuromonitoring of Pediatric and Adult Extracorporeal Membrane Oxygenation Patients: The Importance of Continuous Bedside Tools in Driving Neuroprotective Clinical Care

Author

Tabet, Margherita, primary, Custer, Chasity, additional, Khan, Imad R., additional, Sanford, Ethan, additional, Sharma, Jayesh, additional, Choe, Regine, additional, Singh, Sumit, additional, Sirsi, Deepa, additional, Olson, DaiWai M., additional, Morriss, Michael Craig, additional, Raman, Lakshmi, additional, and Busch, David R., additional

Published
2023
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19. Correlations Between Quantitative EEG Parameters and Cortical Blood Flow in Patients Undergoing Extracorporeal Membrane Oxygenation With and Without Encephalopathy

Author

Khan, Imad R., primary, Dar, Irfaan A., additional, Johnson, Thomas W., additional, Loose, Emily, additional, Xu, Yama Y., additional, Santiago, Esmeralda, additional, Donohue, Kelly L., additional, Marinescu, Mark A., additional, Gosev, Igor, additional, Schifitto, Giovanni, additional, Maddox, Ross K., additional, Busch, David R., additional, Choe, Regine, additional, and Selioutski, Olga, additional

Published
2023
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20. Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine

Author

Ko, Tiffany S, Mavroudis, Constantine D, Baker, Wesley B, Morano, Vincent C, Mensah-Brown, Kobina, Boorady, Timothy W, Schmidt, Alexander L, Lynch, Jennifer M, Busch, David R, Gentile, Javier, Bratinov, George, Lin, Yuxi, Jeong, Sejin, Melchior, Richard W, Rosenthal, Tami M, Shade, Brandon C, Schiavo, Kellie L, Xiao, Rui, Gaynor, J William, Yodh, Arjun G, Kilbaugh, Todd J, and Licht, Daniel J

Published
2020
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24. Non-invasive bedside assessment of microvascular and endothelial health in severe COVID-19 patients: the international HEMOCOVID-19 study

Author

Cortese, Lorenzo, primary, Zanoletti, Marta, additional, Bacchin de Oliveira, Laís, additional, Barcelona, Miquel, additional, Bernardes Delazari, Lilian Elisabete, additional, Buckley, Erin M., additional, Busch, David R., additional, Caballer, Alba, additional, Carbajal Robles, Verónica, additional, Castro, Pedro, additional, Cavallaro Barauna Lima, Ana Lucia, additional, Cheruku, Sreekanth, additional, Chiscano, Luis, additional, Choi, Christopher, additional, Mesquita, Rickson C., additional, Dave, Siddharth, additional, dos Santos Roceto Ratti, Lígia, additional, Eiras Falcão, Antonio Luis, additional, Espinal, Cristina, additional, Fernández, Sara, additional, Ferrer, Ricard, additional, Font, Francesc, additional, García-de-Acilu, Marina, additional, Grasselli, Giacomo, additional, Gruartmoner, Guillem, additional, Guzzardella, Amedeo, additional, Karadeniz, Umut, additional, Lahsaei, Peiman, additional, Lívio Emídio, Gabriela, additional, Marin Corral, Judith, additional, Matas, Ana, additional, Menezes Forti, Rodrigo, additional, Mera, Abraham, additional, Monte De Oca Hernández, Felix Jerandy, additional, Myers, Tim, additional, Nogales, Sara, additional, Olson, DaiWai, additional, Pagliazzi, Marco, additional, Parada Guzmán, Melvin, additional, Pérez Pacheco, Argelia, additional, Pérez Terán, Puri, additional, Picazo, Lucia, additional, Pineda Vásquez, Diana, additional, Quiroga Soto, Andrés Fabian, additional, Quispe Siccha, Rosa Maria, additional, Romero, David, additional, Santillán Aguayo, Enrique, additional, Serra, Isabel, additional, Serrano Loyola, Raúl, additional, Téllez Santoyo, Adrian, additional, Utino Taniguchi, Leandro, additional, Vilà, Clara, additional, Weinmann, M., additional, Zanella, Alberto, additional, Mesquida, Jaume, additional, and Durduran, Turgut, additional

Published
2022
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27. Additional file 1 of Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease

Author

Gregori-Pla, Clara, Rickson C. Mesquita, Favilla, Christopher G., Busch, David R., Blanco, Igor, Zirak, Peyman, Frisk, Lisa Kobayashi, Avtzi, Stella, Maruccia, Federica, Giacalone, Giacomo, Cotta, Gianluca, Camps-Renom, Pol, Mullen, Michael T., Martí-Fàbregas, Joan, Prats-Sánchez, Luís, Martínez-Domeño, Alejandro, Kasner, Scott E., Greenberg, Joel H., Zhou, Chao, Edlow, Brian L., Putt, Mary E., Detre, John A., Yodh, Arjun G., Durduran, Turgut, and Delgado-Mederos, Raquel

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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28. Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units

Author

Mesquida, Jaume, Caballer, A., Cortese, L., Vila, C., Karadeniz, U., Pagliazzi, M., Zanoletti, M., Pacheco, A. Pérez, Castro, P., García-de-Acilu, M., Mesquita, R. C., Busch, D. R., Durduran, T., Durduran, Turgut, Pagliazzi, Marco, Cortese, Lorenzo, Zanoletti, Marta, Karadeniz, Umut, Caballer, Alba, Nogales, Sara, Espinal, Cristina, Gruartmoner, Guillem, Terán, Puri Pérez, Vilà, Clara, Picazo, Lucía, Ferrer, Ricard, De Acilu, Marina García, Chiscano, Luis, Mera, Abraham, Castro, Pedro, Téllez, Adrián, Fernández, Sara, Matas, Ana, Fuentes, Fernando, Serra, Isabel, Romero, David, Font, Francesc, Myers, Tim, Busch, David R., Dave, Siddharth, Cheruku, Sreekanth, Choi, Christopher, Lahsaei, Peiman, Olson, DaiWai, Pacheco, Argelia Pérez, Quispe Siccha, Rosa María, Liceaga, Eduardo, De Oca Hernández, Félix Jerandy Monte, Besen, Bruno Adler Maccagnan Pinheiro, Taniguchi, Leandro Utino, Mendes, Pedro Vitale, Mesquita, Rickson Coelho, Soto, Andrés Fabián Quiroga, Aventurato, Italo Karmann, de Oliveira, Laís Bacchin, Delazari, Lilian Elisabete Bernardes, dos Santos, Lígia, Ratti, Roceto, Falcão, Antonio Luis Eiras, Marin-Corral, Judith, Serrano-Loyola, Raúl, Carbajal-Robles, Verónica, Santillan-Aguayo, Enrique, Parada-Guzmán, Melvin, Menezes-Forti, Rodrigo, Bacchin, Luis, Lívio-Emidio, Gabriela, Institut Català de la Salut, [Mesquida J, Caballer A] Àrea de Crítics, Parc Taulí Hospital Universitari, Sabadell, Spain. [Cortese L, Karadeniz U, Pagliazzi M] ICFO Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain. [Vila C] Servei de Medicina Intensiva, Parc Salut Mar Hospital, Barcelona, Spain. [García-de-Acilu M] Servei de Cures Intensives, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Male, Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units::Respiratory Care Units [HEALTH CARE], ARDS, medicine.medical_treatment, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, medicine.disease_cause, COVID-19 (Malaltia), Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Blood Circulation::Microcirculation [PHENOMENA AND PROCESSES], Severity of Illness Index, instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::unidades hospitalarias::unidades de cuidados intensivos::unidades de cuidados respiratorios [ATENCIÓN DE SALUD], Hypoxemia, Microcirculació, 0302 clinical medicine, Blood vessels, Fraction of inspired oxygen, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Medicine, Prospective Studies, Endothelial dysfunction, Respiratory system, Unitats de cures intensives, Infrared spectroscopy, Vasos sanguinis, Respiratory Distress Syndrome, Intensive care units, Respiratory Care Units, Respiratory disease, Medical emergencies. Critical care. Intensive care. First aid, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Middle Aged, enfermedades respiratorias::enfermedades pulmonares::síndrome de dificultad respiratoria del adulto [ENFERMEDADES], Intensive Care Units, Cardiology, Trastorns microcirculatoris, Female, medicine.symptom, Nasal cannula, Brazil, Adult, Otros calificadores::/fisiología [Otros calificadores], medicine.medical_specialty, Other subheadings::/physiology [Other subheadings], Respiratory Tract Diseases::Lung Diseases::Respiratory Distress Syndrome, Adult [DISEASES], 03 medical and health sciences, Near-infrared spectroscopy, Internal medicine, Intensive care, Humans, fenómenos fisiológicos respiratorios y circulatorios::fenómenos fisiológicos cardiovasculares::circulación sanguínea::microcirculación [FENÓMENOS Y PROCESOS], Muscle, Skeletal, Mexico, Aged, Mechanical ventilation, RC86-88.9, business.industry, SARS-CoV-2, Research, Microcirculation, Espectroscòpia infraroja, COVID-19, medicine.disease, 030228 respiratory system, Spain, Microvessels, Pulmons - Malalties - Complicacions, business
Abstract

Background COVID-19 is primarily a respiratory disease; however, there is also evidence that it causes endothelial damage in the microvasculature of several organs. The aim of the present study is to characterize in vivo the microvascular reactivity in peripheral skeletal muscle of severe COVID-19 patients. Methods This is a prospective observational study carried out in Spain, Mexico and Brazil. Healthy subjects and severe COVID-19 patients admitted to the intermediate respiratory (IRCU) and intensive care units (ICU) due to hypoxemia were studied. Local tissue/blood oxygen saturation (StO2) and local hemoglobin concentration (THC) were non-invasively measured on the forearm by near-infrared spectroscopy (NIRS). A vascular occlusion test (VOT), a three-minute induced ischemia, was performed in order to obtain dynamic StO2 parameters: deoxygenation rate (DeO2), reoxygenation rate (ReO2), and hyperemic response (HAUC). In COVID-19 patients, the severity of ARDS was evaluated by the ratio between peripheral arterial oxygen saturation (SpO2) and the fraction of inspired oxygen (FiO2) (SF ratio). Results Healthy controls (32) and COVID-19 patients (73) were studied. Baseline StO2 and THC did not differ between the two groups. Dynamic VOT-derived parameters were significantly impaired in COVID-19 patients showing lower metabolic rate (DeO2) and diminished endothelial reactivity. At enrollment, most COVID-19 patients were receiving invasive mechanical ventilation (MV) (53%) or high-flow nasal cannula support (32%). Patients on MV were also receiving sedative agents (100%) and vasopressors (29%). Baseline StO2 and DeO2 negatively correlated with SF ratio, while ReO2 showed a positive correlation with SF ratio. There were significant differences in baseline StO2 and ReO2 among the different ARDS groups according to SF ratio, but not among different respiratory support therapies. Conclusion Patients with severe COVID-19 show systemic microcirculatory alterations suggestive of endothelial dysfunction, and these alterations are associated with the severity of ARDS. Further evaluation is needed to determine whether these observations have prognostic implications. These results represent interim findings of the ongoing HEMOCOVID-19 trial. Trial registration ClinicalTrials.gov NCT04689477. Retrospectively registered 30 December 2020.

Published
2021

30. Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine

Author

Padawer-Curry, Jonah A., primary, Volk, Lindsay E., additional, Mavroudis, Constantine D., additional, Ko, Tiffany S., additional, Morano, Vincent C., additional, Busch, David R., additional, Rosenthal, Tami M., additional, Melchior, Richard W., additional, Shade, Brandon C., additional, Schiavo, Kellie L., additional, Boorady, Timothy W., additional, Schmidt, Alexander L., additional, Andersen, Kristen N., additional, Breimann, Jake S., additional, Jahnavi, Jharna, additional, Mensah-Brown, Kobina G., additional, Yodh, Arjun G., additional, Mascio, Christopher E., additional, Kilbaugh, Todd J., additional, Licht, Daniel J., additional, White, Brian R., additional, and Baker, Wesley B., additional

Published
2021
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32. Non-invasive estimation of intracranial pressure by fast diffuse correlation spectroscopy: a multi-center study

Author

Fischer, Jonas B., primary, Tagliabue, Susanna, additional, Maruccia, Federica, additional, Jiménez-Sánchez, Amelia, additional, Sathialingam, Eashani, additional, Baker, Wesley B., additional, Eken, Aykut, additional, Ghouse, Ameer, additional, Rey-Perez, Anna, additional, Báguena, Marcelino, additional, Rosas, Katiuska, additional, Sadan, Ofer, additional, Kandiah, Prem A., additional, Samuels, Owen B., additional, Balu, Ramani, additional, Zucca, Riccardo, additional, Weigel, Udo M., additional, Busch, David R., additional, Buckley, Erin M., additional, Yodh, Arjun G., additional, Licht, Daniel J., additional, Kofke, W. Andrew, additional, Poca, Maria A., additional, Piella, Gemma, additional, Sahuquillo, Juan, additional, and Durduran, Turgut, additional

Published
2021
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34. Towards detection of brain injury using multimodal non-invasive neuromonitoring in adults undergoing extracorporeal membrane oxygenation

Author

Dar, Irfaan A., primary, Khan, Imad R., additional, Maddox, Ross K., additional, Selioutski, Olga, additional, Donohue, Kelly L., additional, Marinescu, Mark A., additional, Prasad, Sunil M., additional, Quazi, Nadim H., additional, Donlon, Jack S., additional, Loose, Emily A., additional, Ramirez, Gabriel A., additional, Ren, Jingxuan, additional, Majeski, Joseph B., additional, Abramson, Kenneth, additional, Durduran, Turgut, additional, Busch, David R., additional, and Choe, Regine, additional

Published
2020
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37. Application of Non-Invasive Cerebral Blood Flow Monitoring Modalities in Adults Undergoing Extracorporeal Membrane Oxygenation

Author

Dar, Irfaan A., primary, Khan, Imad R., additional, Maddox, Ross K., additional, Prasad, Sunil M., additional, Selioutski, Olga, additional, Donohue, Kelly L., additional, Abramson, Kenneth, additional, Yodh, Arjun G., additional, Durduran, Turgut, additional, Busch, David R., additional, and Choe, Regine, additional

Published
2020
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40. Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine

Author

Ko, Tiffany S, primary, Mavroudis, Constantine D, additional, Baker, Wesley B, additional, Morano, Vincent C, additional, Mensah-Brown, Kobina, additional, Boorady, Timothy W, additional, Schmidt, Alexander L, additional, Lynch, Jennifer M, additional, Busch, David R, additional, Gentile, Javier, additional, Bratinov, George, additional, Lin, Yuxi, additional, Jeong, Sejin, additional, Melchior, Richard W, additional, Rosenthal, Tami M, additional, Shade, Brandon C, additional, Schiavo, Kellie L, additional, Xiao, Rui, additional, Gaynor, J William, additional, Yodh, Arjun G, additional, Kilbaugh, Todd J, additional, and Licht, Daniel J, additional

Published
2018
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41. Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy

Author

Busch, David R., primary, Balu, Ramani, additional, Baker, Wesley B., additional, Guo, Wensheng, additional, He, Lian, additional, Diop, Mamadou, additional, Milej, Daniel, additional, Kavuri, Venkaiah, additional, Amendolia, Olivia, additional, St. Lawrence, Keith, additional, Yodh, Arjun G., additional, and Kofke, W. Andrew, additional

Published
2018
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48. Noninvasive Optical Monitoring of Cerebral Blood Flow, Critical Closing Pressure, and Arteriole Compliance in Adult Human Subjects

Author

Baker, Wesley, primary, Parthasarathy, Ashwin B., additional, He, Lian, additional, Kavuri, Venkaiah C., additional, Diop, Mamadou, additional, Milej, Daniel F., additional, Busch, David R., additional, Gannon, Kimberly P., additional, Mullen, Michael T., additional, Detre, John A., additional, Licht, Daniel, additional, St. Lawrence, Keith, additional, Balu, Ramani, additional, Kofke, W. Andrew, additional, and Yodh, Arjun G., additional

Published
2018
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