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1. The epigenetic hallmark of early-life α-hexabromocyclododecane exposure: From cerebellar 6-mA levels to locomotor performance in adulthood

Author

Cyrielle Holuka, Chloé Morel, Sarah Roth, Yordenca Lamartinière, Sophie B. Mériaux, Justine Paoli, Pauline Guébels, Radu C. Duca, Lode Godderis, An van Nieuwenhuyse, Pascaline Kremarik-Bouillaud, Ronan Cariou, Claude Emond, Henri Schroeder, Jonathan D. Turner, and Nathalie Grova

Subjects
α-hexabromocyclododecane, Early-life exposure, 6 methyl-adenine, Cerebellum, Developmental neurotoxicity, Rat, Environmental sciences, GE1-350
Abstract

There is a growing evidence that methylation at the N6 position of adenine (6-mA), whose modulation occurs primarily during development, would be a reliable epigenetic marker in eukaryotic organisms. The present study raises the question as to whether early-life exposure to α-hexabromocyclododecane (α-HBCDD), a brominated flame retardant, may trigger modifications in 6-mA epigenetic hallmarks in the brain during the development which, in turn could affect the offspring behaviour in adulthood. Pregnant Wistar rats were split into two groups: control and α-HBCDD (66 ng/kg/per os, G0-PND14). At PND1, α-HBCDD levels were assessed in brain and liver by LC-MS/MS. At PND14, DNA was isolated from the offspring’s cerebellum. DNA methylation was measured by 6-mA-specific immunoprecipitation and Illumina® sequencing (MEDIP-Seq). Locomotor activity was finally evaluated at PND120. In our early-life exposure model, we confirmed that α-HBCDD can cross the placental barrier and be detected in pups at birth. An obvious post-exposure phenotype with locomotor deficits was observed when the rats reached adulthood. This was accompanied by sex-specific over-methylation of genes involved in the insulin signaling pathway, MAPK signaling pathway as well as serotonergic and GABAergic synapses, potentially altering the normal process of neurodevelopment with consequent motor impairments crystalized at adulthood.

Published
2023
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3. QUBIC VII: The feedhorn-switch system of the technological demonstrator

Author

F. Cavaliere, A. Mennella, M. Zannoni, P. Battaglia, E. S. Battistelli, D. Burke, G. D’Alessandro, P. de Bernardis, M. De Petris, C. Franceschet, L. Grandsire, J. -Ch. Hamilton, B. Maffei, E. Manzan, S. Marnieros, S. Masi, C. O’Sullivan, A. Passerini, F. Pezzotta, M. Piat, A. Tartari, S. A. Torchinsky, D. Viganò, F. Voisin, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, B. Bélier, A. Baù, S. Banfi, D. Bennett, L. Bergé, J. -Ph. Bernard, M. Bersanelli, M. -A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Buzi, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, M. Gómez Berisso, M. M. Gamboa Lerena, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, E. Pagana, A. Paiella, F. Pajot, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, C. Scóccola, A. Schillaci, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J. -P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, N. Vittorio, F. Wicek, M. Wright, and A. Zullo, Cavaliere, F, Mennella, A, Zannoni, M, Battaglia, P, Battistelli, E, De Bernardis, P, Burke, D, D'Alessandro, G, De Petris, M, Franceschet, C, Grandsire, L, Hamilton, J, Maffei, B, Manzan, B, Marnieros, S, Masi, S, O'Sullivan, C, Passerini, A, Pezzotta, F, Piat, M, Tartari, A, Torchinsky, S, Viganò, D, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Pastoriza, H, Pelosi, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), QUBIC, D’Alessandro, G, de Bernardis, P, Manzan, E, O’Sullivan, C, Pagana, E, Perbost, C, Perciballi, M, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Vittorio, N, Wicek, F, Wright, M, and Zullo, A

Subjects
CMBR polarisation, Physics - Instrumentation and Detectors, Manchester Cancer Research Centre, Settore FIS/05, ResearchInstitutes_Networks_Beacons/mcrc, FOS: Physical sciences, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), CMBR detectors, CMBR experiments, gravitational waves and CMBR polarization, FIS/05 - ASTRONOMIA E ASTROFISICA, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], CMBR experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), CMBR detector
Abstract

We present the design, manufacturing and performance of the horn-switch system developed for the technological demonstrator of QUBIC (the $Q$\&$U$ Bolometric Interferometer for Cosmology). This system is constituted of 64 back-to-back dual-band (150\,GHz and 220\,GHz) corrugated feed-horns interspersed with mechanical switches used to select desired baselines during the instrument self-calibration. We manufactured the horns in aluminum platelets milled by photo-chemical etching and mechanically tightened with screws. The switches are based on steel blades that open and close the wave-guide between the back-to-back horns and are operated by miniaturized electromagnets. We also show the current development status of the feedhorn-switch system for the QUBIC full instrument, based on an array of 400 horn-switch assemblies., 30 pages, 28 figures. Accepted for submission to JCAP

Published
2022
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4. QUBIC VII: The feedhorn-switch system of the technological demonstrator

Author

Cavaliere, F, Mennella, A, Zannoni, M, Battaglia, P, Battistelli, E, Burke, D, D’Alessandro, G, de Bernardis, P, De Petris, M, Franceschet, C, Grandsire, L, Hamilton, J, Maffei, B, Manzan, E, Marnieros, S, Masi, S, O’Sullivan, C, Passerini, A, Pezzotta, F, Piat, M, Tartari, A, Torchinsky, S, Viganò, D, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Bélier, B, Baù, A, Banfi, S, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Gómez Berisso, M, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Pagana, E, Paiella, A, Pajot, F, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Vittorio, N, Wicek, F, Wright, M, Zullo, A, F. Cavaliere, A. Mennella, M. Zannoni, P. Battaglia, E. S. Battistelli, D. Burke, G. D’Alessandro, P. de Bernardis, M. De Petris, C. Franceschet, L. Grandsire, J. -Ch. Hamilton, B. Maffei, E. Manzan, S. Marnieros, S. Masi, C. O’Sullivan, A. Passerini, F. Pezzotta, M. Piat, A. Tartari, S. A. Torchinsky, D. Viganò, F. Voisin, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, B. Bélier, A. Baù, S. Banfi, D. Bennett, L. Bergé, J. -Ph. Bernard, M. Bersanelli, M. -A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Buzi, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, M. Gómez Berisso, M. M. Gamboa Lerena, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, E. Pagana, A. Paiella, F. Pajot, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, C. Scóccola, A. Schillaci, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J. -P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, N. Vittorio, F. Wicek, M. Wright, and A. Zullo, Cavaliere, F, Mennella, A, Zannoni, M, Battaglia, P, Battistelli, E, Burke, D, D’Alessandro, G, de Bernardis, P, De Petris, M, Franceschet, C, Grandsire, L, Hamilton, J, Maffei, B, Manzan, E, Marnieros, S, Masi, S, O’Sullivan, C, Passerini, A, Pezzotta, F, Piat, M, Tartari, A, Torchinsky, S, Viganò, D, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Bélier, B, Baù, A, Banfi, S, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Gómez Berisso, M, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Pagana, E, Paiella, A, Pajot, F, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Vittorio, N, Wicek, F, Wright, M, Zullo, A, F. Cavaliere, A. Mennella, M. Zannoni, P. Battaglia, E. S. Battistelli, D. Burke, G. D’Alessandro, P. de Bernardis, M. De Petris, C. Franceschet, L. Grandsire, J. -Ch. Hamilton, B. Maffei, E. Manzan, S. Marnieros, S. Masi, C. O’Sullivan, A. Passerini, F. Pezzotta, M. Piat, A. Tartari, S. A. Torchinsky, D. Viganò, F. Voisin, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, B. Bélier, A. Baù, S. Banfi, D. Bennett, L. Bergé, J. -Ph. Bernard, M. Bersanelli, M. -A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Buzi, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, M. Gómez Berisso, M. M. Gamboa Lerena, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, E. Pagana, A. Paiella, F. Pajot, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, C. Scóccola, A. Schillaci, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J. -P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, N. Vittorio, F. Wicek, M. Wright, and and A. Zullo

Abstract

We present the design, manufacturing and performance of the horn-switch system developed for the technological demonstrator of QUBIC (the Q&U Bolometric Interferometer for Cosmology). This system consists of 64 back-to-back dual-band (150 GHz and 220 GHz) corrugated feed-horns interposed with mechanical switches used to select desired baselines during the instrument self-calibration. We manufactured the horns in aluminum platelets milled by photo-chemical etching and mechanically tightened with screws. The switches are based on steel blades that open and close the waveguide between the back-to-back horns and are operated by miniaturized electromagnets. The measured electromagnetic performance of the feedhorns agrees with simulations. In particular we obtained a return loss around -20 dB up to 230 GHz and beam patterns in agreement with single-mode simulations down to -30 dB. The switches for this prototype were designed and built for the 150 GHz band. In this frequency range we find return and insertion losses consistent with expectations (< -25 dB and ∼-0.1 dB, respectively) and an isolation larger than 70 dB. In this paper we also show the current development status of the feedhorn-switch system for the QUBIC full instrument, based on an array of 400 horn-switch assemblies.

Published
2022

5. QUBIC Experiment Toward the First Light

Author

G. D’Alessandro, E. S. Battistelli, P. de Bernardis, M. De Petris, M. M. Gamboa Lerena, L. Grandsire, J.-Ch. Hamilton, S. Marnieros, S. Masi, A. Mennella, L. Mousset, C. O’Sullivan, M. Piat, A. Tartari, S. A. Torchinsky, F. Voisin, M. Zannoni, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, S. Banfi, A. Baù, B. Bélier, D. Bennett, L. Bergé, J.-Ph. Bernard, M. Bersanelli, M.-A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Burke, D. Buzi, F. Cavaliere, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, C. Franceschet, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. Gómez Berisso, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, B. Maffei, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, A. Paiella, F. Pajot, A. Passerini, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Pezzotta, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, G. Presta, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, A. Schillaci, C. G. Scóccola, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J.-P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, D. Viganò, N. Vittorio, F. Wicek, M. Wright, A. Zullo, D’Alessandro, G, Battistelli, E, de Bernardis, P, De Petris, M, Gamboa Lerena, M, Grandsire, L, Hamilton, J, Marnieros, S, Masi, S, Mennella, A, Mousset, L, O’Sullivan, C, Piat, M, Tartari, A, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Presta, G, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Wicek, F, Wright, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), and QUBIC

Subjects
Instruments, mm-wave, Applications, astrophysics and cosmology, Settore FIS/05, Applications: astrophysics and cosmology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, FIS/05 - ASTRONOMIA E ASTROFISICA, FIS/01 - FISICA SPERIMENTALE, Settore FIS/05 - Astronomia e Astrofisica, Instruments: mm-wave, Instruments: mm-wave · Applications: astrophysics and cosmology, General Materials Science, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

International audience; The Q & U Bolometric Interferometer for Cosmology (QUBIC) is a cosmology experiment that aims to measure the B-mode polarization of the cosmic microwave background (CMB). Measurements of the primordial B-mode pattern of the CMB polarization are in fact among the most exciting goals in cosmology as it would allow testing of the inflationary paradigm. Many experiments are attempting to measure the B-modes, from the ground and the stratosphere, using imaging Stokes polarimeters. The QUBIC collaboration developed an innovative concept to measure CMB polarization using bolometric interferometry. This approach mixes the high sensitivity of bolometric detectors with the accurate control of systematics due to the interferometric layout of the instrument. We present the calibration results for the Technological Demonstrator, before its commissioning in the Argentinian observing site and preparation for first light.

Published
2022
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6. Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides

Author

Aleksandra Fučić, Michael S. Bloom, Helle Raun Andersen, Karen S. Galea, Tihana Maric, Radu C. Duca, Kelly Garcia, and John E. Vena

Subjects
Male, Medical surveillance, Health, Toxicology and Mutagenesis, Disease, Review, 010501 environmental sciences, 01 natural sciences, 0302 clinical medicine, HUMAN PARAOXONASE PON1, Pregnancy, POLYCHLORINATED-BIPHENYLS, Medicine, PERSISTENT ORGANIC POLLUTANTS, CORD BLOOD, Transplacental, media_common, Reproductive health, Public, Environmental & Occupational Health, 030219 obstetrics & reproductive medicine, Neurodegenerative Diseases, Environmental exposure, 3. Good health, Reproductive Health, female, Female, infertility, Life Sciences & Biomedicine, Infertility, transplacental, media_common.quotation_subject, HORMONE-LEVELS, ENDOCRINE-DISRUPTING CHEMICALS, Fertility, Environmental Sciences & Ecology, 03 medical and health sciences, male, Environmental health, Occupational Exposure, Humans, Pesticides, PYRETHROID INSECTICIDE EXPOSURE, 0105 earth and related environmental sciences, PRENATAL EXPOSURE, Science & Technology, business.industry, Public Health, Environmental and Occupational Health, Environmental Exposure, Pesticide, medicine.disease, SEMEN QUALITY, IN-UTERO EXPOSURE, business, Environmental Sciences
Abstract

A marked reduction in fertility and an increase in adverse reproductive outcomes during the last few decades have been associated with occupational and environmental chemical exposures. Exposure to different types of pesticides may increase the risks of chronic diseases, such as diabetes, cancer, and neurodegenerative disease, but also of reduced fertility and birth defects. Both occupational and environmental exposures to pesticides are important, as many are endocrine disruptors, which means that even very low-dose exposure levels may have measurable biological effects. The aim of this review was to summarize the knowledge collected between 2000 and 2020, to highlight new findings, and to further interpret the mechanisms that may associate pesticides with infertility, abnormal sexual maturation, and pregnancy complications associated with occupational, environmental and transplacental exposures. A summary of current pesticide production and usage legislation is also included in order to elucidate the potential impact on exposure profile differences between countries, which may inform prevention measures. Recommendations for the medical surveillance of occupationally exposed populations, which should be facilitated by the biomonitoring of reduced fertility, is also discussed. ispartof: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH vol:18 issue:12 ispartof: location:Switzerland status: published

Published
2021
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7. Detection chain and electronic readout of the QUBIC instrument

Author

L. M. Mundo, S. Marnieros, D. Fracchia, A. Mattei, R. Puddu, S. Spinelli, A. Passerini, Federico Nati, V. Gilles, K. Ganga, B. García, Giuseppe D'Alessandro, F. Wicek, P. A. R. Ade, Diego Harari, J. Bonaparte, F. Pezzotta, Massimo Gervasi, F. Incardona, M. E. García Redondo, M. Platino, L. Grandsire, J. D. Murphy, Damien Rambaud, E. Jules, M. Wright, C. Kristukat, L. Dumoulin, E. Olivieri, B. Maffei, Alessandro Paiella, J. Bonis, J.-P. Thermeau, D. Prêle, H. Pastoriza, Michel Piat, M. Gómez Berisso, M. Perciballi, F. Piacentini, D. Burke, Mark McCulloch, A. Zullo, L. H. Arnaldi, Giampaolo Pisano, A. Baù, L.P. Ferreyro, C. Perbost, C. Duca, C. Franceschet, L. Mousset, J. A. Murphy, D. Viganò, Gustavo E. Romero, Martin Giard, Emory F. Bunn, Alessandro Schillaci, Gregory S. Tucker, P. Chanial, L. A. Montier, M.-A. Bigot-Sazy, Alejandro Almela, A. Etchegoyen, Marco Bersanelli, E. Rasztocky, M. Gaspard, Nicola Vittorio, Mario Zannoni, A. Pelosi, S. Azzoni, P. de Bernardis, T. D. Hoang, S. Banfi, W. Marty, A. Mennella, S. Scully, M. M. Gamboa Lerena, Elia S. Battistelli, Andrea Tartari, J.G. Alberro, D. Gayer, Alessandro Coppolecchia, C. Oriol, J.M. Salum, J. Aumont, D. Bennett, S. Loucatos, Silvia Masi, Marcin Gradziel, S. Dheilly, François Pajot, A.C. Cobos Cerutti, C. Chapron, A. Fasciszewski, J.-Ch. Hamilton, M. González, M. Tomasi, Créidhe O'Sullivan, Laurent Bergé, G. Amico, D. Buzi, A.D. Supanitsky, D. Auguste, Gianluca Polenta, Francesco Cavaliere, P. Ringegni, G. Stankowiak, Luca Lamagna, Steve Torchinsky, L. Mele, Andrew May, Peter Timbie, F. Columbro, F. Voisin, C. Tucker, J. Kaplan, B. Bélier, R. Charlassier, M. R. Hampel, G. de Gasperis, C. Scóccola, Lucio Piccirillo, Thibaut Louis, Sophie Henrot-Versille, D. Melo, J.-Ph. Bernard, M. Stolpovskiy, Y. Giraud-Héraud, M. De Leo, M. De Petris, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Zmuidzinas, Jonas, Gao, Jian-Rong, Stankowiak, G, Piat, M, Battistelli, E, D'Alessandro, G, de Bernardis, P, De Petris, M, González, M, Grandsire, L, Hamilton, J, Hoang, T, Masi, S, Marnieros, S, Mennella, A, Mousset, L, O'Sullivan, C, Prêle, D, Tartari, A, Thermeau, J, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Bélier, B, Baù, A, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, de Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Héraud, Y, Gómez Berisso, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Rasztocky, E, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stolpovskiy, M, Supanitsky, A, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Wicek, F, Wright, M, and Zullo, A

Subjects
QUBIC, Cosmic microwave background, 02 engineering and technology, CMB, SQUID, 7. Clean energy, Superconducting QUantum Interference Device, 030218 nuclear medicine & medical imaging, law.invention, TDM, FIS/05 - ASTRONOMIA E ASTROFISICA, 03 medical and health sciences, 020210 optoelectronics & photonics, 0302 clinical medicine, Optics, Application-specific integrated circuit, law, Cosmic Microwave Background, B-modes, 0202 electrical engineering, electronic engineering, information engineering, Noise-equivalent power, [PHYS]Physics [physics], Physics, TES, business.industry, Bolometer, Time constant, CMB instrumentation, bolometric interferometry, Transition Edge Sensor, Interferometry, Transition edge sensor, business
Abstract

International audience; The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10-16W= p √Hz

Published
2020
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8. Calibration of QUBIC: The Q and U bolometric interferometer for cosmology

Author

D. Melo, Peter T. Timbie, G. Polenta, L. Mele, S. Loucatos, K. Ganga, Alejandro Almela, Luca Lamagna, W. Marty, Gustavo E. Romero, Giuseppe D'Alessandro, D. Burke, Emory F. Bunn, H. Pastoriza, D. Harari, L. Montier, E. Rasztocky, F. Piacentini, C. Duca, L.P. Ferreyro, L. M. Mundo, D. Prêle, Andrew May, C. Perbost, J.-Ph. Bernard, M. Stolpovskiy, P. de Bernardis, Francesco Cavaliere, J. A. Murphy, P. A. R. Ade, M. Platino, Federico Nati, Créidhe O'Sullivan, M. Wright, Cristian Franceschet, M. Gómez Berisso, M. Giard, M. Gaspard, P. Chanial, E. Olivieri, Alessandro Schillaci, D. Fracchia, C. Kristukat, Y. Giraud-Héraud, A. Baù, L. Mousset, J. Kaplan, C. Oriol, A. Mattei, F. Columbro, J. Bonaparte, M. E. García Redondo, B. Bélier, Nicola Vittorio, L. Grandsire, Silvia Masi, J. Bonis, C. Tucker, G. Amico, Federico Pezzotta, M. Piat, J.-P. Thermeau, F. Incardona, D. Buzi, A. Mennella, Marcin Gradziel, A.D. Supanitsky, J. D. Murphy, Gregory S. Tucker, E. Jules, A. Passerini, V. Gilles, J.M. Salum, S. Dheilly, M. Perciballi, M. M. Gamboa Lerena, F. Voisin, S. A. Torchinsky, Alessandro Paiella, Damien Rambaud, Bruno Maffei, J.G. Alberro, A.C. Cobos Cerutti, C. Chapron, L. Bergé, Mark McCulloch, S. Marnieros, S. Azzoni, D. Auguste, Giampaolo Pisano, F. Pajot, F. Wicek, R. Puddu, Elia S. Battistelli, D. Gayer, S. Banfi, L. H. Arnaldi, J. Aumont, Massimo Gervasi, M. De Leo, D. Bennett, A. Zullo, S. Spinelli, M. Tomasi, Lucio Piccirillo, C. Scóccola, M. De Petris, A. Etchegoyen, Thibaut Louis, Marco Bersanelli, Sophie Henrot-Versille, Mario Zannoni, M.-A. Bigot-Sazy, M. González, A. Pelosi, S. Scully, P. Ringegni, G. Stankowiak, J.-Ch. Hamilton, L. Dumoulin, A. Tartari, D. Viganò, R. Charlassier, M. R. Hampel, G. de Gasperis, Bruce Rafael Mellado Garcia, Alessandro Coppolecchia, A. Fasciszewski, Zmuidzinas, Jonas, Murphy, J, Burke, D, Gamboa Lerena, M, Hamilton, J, Mousset, L, De Petris, M, O'Sullivan, C, Torchinsky, S, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Bélier, B, Battistelli, E, Baù, A, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, D'Alessandro, G, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Grandsire, L, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Mennella, A, Montier, L, Mundo, L, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Voisin, F, Wicek, F, Wright, M, Zannoni, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), and Gao, Jian-Rong

Subjects
QUBIC, Instrumentation, interferometer, Cosmic microwave background, measurement methods, CDM, cosmic background radiation: polarization, 02 engineering and technology, Astrophysics::Cosmology and Extragalactic Astrophysics, CMB, 7. Clean energy, 01 natural sciences, Cosmology, law.invention, 010309 optics, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, bolometer, B-mode polarisation, law, 0103 physical sciences, Cosmic Microwave Background, Calibration, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], measure: spectral, detector: design, data-analysis, Physics, instrumentation, calibration, TES, business.industry, Instrument Data, Bolometer, transition edge sensor, Astrophysics::Instrumentation and Methods for Astrophysics, 021001 nanoscience & nanotechnology, sensitivity, Interferometry, B-mode, Transition edge sensor, 0210 nano-technology, business
Abstract

International audience; QUBIC (a Q and U Bolometric Interferometer for Cosmology) is a next generation cosmology experiment designed to detect the B-mode polarisation of the Cosmic Microwave Background (CMB). A B-mode detection is hard evidence of Inflation in the ΛCDM model. QUBIC aims to accomplish this by combining novel technologies to achieve the sensitivity required to detect the faint B-mode signal. QUBIC uses technologies such as a rotating half-wave plate, cryogenics, interferometric horns with self-calibration switches and transition edge sensor bolometers. A Technical Demonstrator (TD) is currently being calibrated in APC in Paris before observations in Argentina in 2021. As part of the calibration campaign, the spectral response of the TD is measured to test and validate QUBIC's spectro-imaging capability. This poster gives an overview of the methods used to measure the spectral response and a comparison of the instrument data with theoretical predictions and optical simulations.

Published
2020
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9. Hair analysis for the biomonitoring of polycyclic aromatic hydrocarbon exposure: comparison with urinary metabolites and DNA adducts in a rat model

Author

Emilie M. Hardy, Nathalie Grova, Brice M.R. Appenzeller, Radu C. Duca, and François Faÿs

Subjects
Health, Toxicology and Mutagenesis, Urinary system, Polycyclic aromatic hydrocarbon, Urine, 010501 environmental sciences, Toxicology, 01 natural sciences, Adduct, DNA Adducts, chemistry.chemical_compound, Biomonitoring, Animals, Rats, Long-Evans, Benzopyrenes, Polycyclic Aromatic Hydrocarbons, 0105 earth and related environmental sciences, chemistry.chemical_classification, Chromatography, Dose-Response Relationship, Drug, 010401 analytical chemistry, Hair analysis, Environmental Exposure, General Medicine, 0104 chemical sciences, chemistry, Pyrene, Environmental Pollutants, Female, DNA, Hair
Abstract

Alongside the analysis of urinary metabolites which are traditional biomarkers of polycyclic aromatic hydrocarbons (PAH) exposure, the possibility of detecting PAH as well as their metabolites in hair has also recently been demonstrated. As the concentration of pollutants detected in hair is not impacted by short-term variations in exposure as can be observed with urine, it accurately represents an individual’s average level of exposure, which is the most relevant information when investigating possible linkages with biological effects. In the current study, based on a rat model exposed to a mixture of PAHs for a 90-day period, the linkage between the PAH exposure level and the resulting concentration of their metabolites in hair was then investigated. The linkage between exposure levels and the concentrations of OH-PAH in hair collected at the end of the experiment were compared to those obtained using urinary concentration of OH-PAH collected from the same animals. Linear relationship between levels of exposure and the concentration of OH-PAH in the rats’ hair (R2 0.722–0.965, p

Published
2018
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10. Single-walled and multi-walled carbon nanotubes induce sequence-specific epigenetic alterations in 16 HBE cells

Author

Deniz Öner, Lode Godderis, Radu C. Duca, Peter Hoet, Jeroen Vanoirbeek, Manosij Ghosh, and Bram Bekaert

Subjects
0301 basic medicine, DNA methylation, epigenetics, Chemistry, MWCNT, 02 engineering and technology, Methylation, 021001 nanoscience & nanotechnology, In vitro, Cell biology, 03 medical and health sciences, 030104 developmental biology, Oncology, CpG site, SWCNT, Nanotoxicology, DNMT1, nanotoxicology, sense organs, Epigenetics, 0210 nano-technology, Gene, Research Paper
Abstract

Recent studies have identified carbon nanotube (CNT)-induced epigenetic changes as one of the key players in patho-physiological response. In the present study, we investigated whether CNT exposure is associated with epigenetic changes in human bronchial epithelial cells (16 HBE), in vitro. We focused on global DNA methylation, methylation of LINE-1 elements and promoter sequence of twelve functionally important genes (SKI, DNMT1, HDAC4, NPAT, ATM, BCL2L11, MAP3K10, PIK3R2, MYO1C, TCF3, FGFR 1 and AGRN). Additionally, we studied the influence of CNT exposure on miRNA expression. Using a LC-MS/MS method and pyrosequencing for LINE-1, we observed no significant changes in global DNA methylation (%) between the concentrations of multi-walled and single-walled CNT (MWCNT and SWCNT, respectively). Significant changes in sequence-specific methylation was observed in at least one CpG site for DNMT1 (SWCNT), HDAC4 (MWCNT), NPAT/ATM (MWCNT and SWCNT), MAP3K10 (MWCNT), PIK3R2 (MWCNT and SWCNT) and MYO1C (SWCNT). While changes in DNA methylation of the genes were relatively small, these changes were associated with changes in RNA expression, especially for MWCNT. However, the study did not reveal any significant alteration in the miRNA expression, associated with MWCNT and SWCNT exposure. Based on our results, mainly MWCNT influence DNA methylation and expression of the studied genes and could have significant impact on several critical cellular processes.

Published
2018
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11. Saturation reduces in-vitro leakage of monomers from composites

Author

Stevan M. Cokic, Kirsten Van Landuyt, Bart Van Meerbeek, Mario Smet, Lode Godderis, Peter Hoet, Radu C. Duca, and Jan De Munck

Subjects
Technology, Bisphenol A, STRESS, Polyurethanes, Leachability, 02 engineering and technology, Polyethylene Glycols, chemistry.chemical_compound, 0302 clinical medicine, Materials Testing, Bisphenol A-Glycidyl Methacrylate, General Materials Science, BISGMA, Composite material, DENTAL RESIN MONOMERS, Materials Science, Biomaterials, Composite materials, Saturation, 021001 nanoscience & nanotechnology, UDMA, Solvent, LIGHT, Monomer, Mechanics of Materials, Methacrylates, 0210 nano-technology, Saturation (chemistry), Life Sciences & Biomedicine, Dental composite, Materials science, Surface Properties, Equilibrium, TOXICOLOGY, Materials Science, Methacrylate, Composite Resins, Gas Chromatography-Mass Spectrometry, Dental Materials, 03 medical and health sciences, Phenols, Polymethacrylic Acids, Dentistry, Oral Surgery & Medicine, Benzhydryl Compounds, General Dentistry, Science & Technology, LEACHABLE COMPONENTS, Ethanol, Elution, 030206 dentistry, chemistry, Dentin-Bonding Agents, Solvents, TEGDMA
Abstract

OBJECTIVE: Accurate knowledge of the quantity of released monomers from composites is important. To evaluate the elution of monomers, polymerized composites are typically immersed in an extraction solvent. The objective was to determine whether the volume of extraction solvent and the immersion time influences monomer leachability from dental composite materials. METHODS: Composite disks of two commercial composites, (Filtek Supreme XTE, 3M ESPE and G-aenial Universal Flo, GC) were prepared. The disks (n=10) were placed in a glass vial with 1ml, 2ml or 3ml of extraction solvent (100% ethanol with deuterated diethylphalate as internal standard). After either 7 or 30 days at 37°C, the supernatant was collected and the amount of released monomers (BisEMA, BisGMA, UDMA, TEGDMA) and bisphenol A was measured with liquid chromatography mass spectroscopy. RESULTS: For both tested composites, the highest amount of released monomers was measured after sample incubation in 3ml, while the lowest amount was measured in 1ml of extraction solvent. Furthermore, 30 days did not result in much more monomer release compared to 7 days, and for most monomers, there was no statistically significant difference in release between 7 and 30 days. SIGNIFICANCE: Release kinetics in in-vitro experiments are also influenced by saturation of the extraction solvent with the leached monomers. This is important as it is unlikely that saturation can be reached in an in-vivo situation, where saliva (or pulpal fluid) is continuously refreshed. Saturation of the extraction solvent can be avoided in-vitro by refreshing the extraction medium after equal time intervals. ispartof: DENTAL MATERIALS vol:34 issue:4 pages:579-586 ispartof: location:England status: published

Published
2018
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12. Une singulière façon d’entrer dans la danse

Author

François Sellal, L. Faure, C. Duca, and Aurelian Ungureanu

Subjects
03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030212 general & internal medicine, Neurology (clinical), business, 030217 neurology & neurosurgery
Published
2017
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13. Forces transmission in the case of SSR structural group

Author

C. Duca and F. Buium

Subjects
Transmission (mechanics), Group (periodic table), law, Topology, Mathematics, law.invention
Abstract

This paper contains the SSR spatial group analysis, following to determinate the forces transmission index. It comes to conclusion, this index is a two variable function, defined by discrete values and graphically represented by a surface. Knowing this function it has been studied a linkage containing the SSR group – the spatial four bar linkage of orthogonal type. To avoid very high values of reactions, the forces transmission index must be inferior limited. Verifying of this limitation is done by the above mentioned surfaces level curves. This method is performed by authors, and it had been used previously for planar linkages only.

Published
2020
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14. 1713c Epigenetics in solvent induced neurobehavioral disorders

Author

Ruxandra Nagy, Minneke Viaene, Manosij Gosh, Radu C. Duca, and Lode Godderis

Subjects
business.industry, Mechanism (biology), Disease, Methylation, Bioinformatics, chemistry.chemical_compound, chemistry, In vivo, DNA methylation, DNMT1, Medicine, Epigenetics, Solvent exposure, business
Abstract

Introduction In order to prevent neurodegenerative diseases such as chronic solvent encephalopathy (CSE), it is important to elucidate the underlying mechanism. Cells are able to respond to occupational stressors by turning on or off specific genes mediated through epigenetic alterations. Consequently, epigenetic mechanisms can play an important role in mediating the effects of solvent exposure on the development of neurobehavioral disorders. Methods We have set-up several studies in a translational design using cell lines, mice and humans exposed to solvents and CSE patients. DNA methylation was measured with liquid chromatography coupled with tandem mass spectrometry for the assessment of 2’-deoxycytidine, 5-methyl-2’-deoxycytidine, 5-hydroxymethyl-2´-deoxycytidine, 5-formyl-2´-deoxycytidine, 5-carboxy-2´-deoxycytidine and pyrosequencing. Results Global DNA methylation and hydroxymethylation was mostly negatively associated with solvent exposure in both in vitro as in vivo studies. DNMT1 CpG1 gene-specific methylation levels were significantly higher in CSE patients as compared to controls, associations that persisted after adjustment for age, gender, alcohol abuse, smoking, level of education and the use of psychotropic medication (p=0.004 and p=0.017, respectively). In addition, in the group of CSE patients there was a positive correlation between the duration of solvent exposure and the percentage of BDNF CpG1 methylation (rs=0.374, p=0.017), which was maintained after adjustment for age and smoking (p Conclusion The study of epigenetic alterations gives us the possibility to study the immediate consequences of exposure and make projections for disease development. These epigenetic marks can be used to develop a set of biomarkers and used in the follow-up of humans.

Published
2018
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15. 915 Maternal occupation is associated with maternal global dna (hydroxy) methylation in the second trimester of pregnancy

Author

Inge Huybrechts, Sas Langie, Gudrun Koppen, Manosij Ghosh, Sara Pauwels, Roland Devlieger, Radu C. Duca, and Lode Godderis

Subjects
DNA Hydroxymethylation, medicine.medical_specialty, Pregnancy, Offspring, Obstetrics, business.industry, Epigenome, Methylation, medicine.disease, chemistry.chemical_compound, chemistry, DNA methylation, medicine, Epigenetics, business, DNA
Abstract

Introduction Environmental factors, such as nutrition and occupational exposure can influence epigenetic marks like DNA methylation, which play a role in the development of chronic diseases. Methods Data of the MAternal Nutrition and Offspring’s Epigenome (MANOE) study was used to assess the effect of maternal occupation on maternal and infant DNA (hydroxy)methylation levels. Mothers were categorised in job categories according to the International Standard Classification of Occupations (ISCO). Maternal global DNA (hydroxy)methylation levels during each trimester of pregnancy and at delivery (n=122) was measured in whole blood via LC-MS/MS. Data were analysed with a one-Way ANOVA. Results We found statistically significant differences in maternal global DNA methylation (p=0.008) and global DNA hydroxymethylation (p=0.004) at 20 weeks of pregnancy. Post hoc tests revealed that global DNA methylation and global DNA hydroxymethylation level was significantly lower when the mother had an intellectual/scientific/artistic profession (6.36% and 0.13%) as opposed to being a manager (7.77%, p=0.007% and 0.22%, p=0.002) or administrative staff (7.71%, p=0.003% and 0.2%, p=0.005). No significant differences between different working groups were found for global DNA (hydroxy)methylation in the first and third trimester of pregnancy and at delivery. Conclusion The mother’s occupation was associated with maternal global DNA (hydroxy)methylation levels only in the second trimester of pregnancy. The change in maternal global DNA (hydroxy)methylation in the second trimester of pregnancy could be due to hormonal changes during pregnancy, a shift in the one-carbon metabolism in the middle of pregnancy, but based on these results we also have to take into account maternal occupational exposure.

Published
2018
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16. Differences in MWCNT- and SWCNT-induced DNA methylation alterations in association with the nuclear deposition

Author

Matthieu Moisse, Diether Lambrechts, Bram Boeckx, Lode Godderis, Peter Hoet, Manosij Ghosh, Katrien Luyts, Deniz Öner, Kirsten Van Landuydt, Marcel Ameloot, Jeroen Vanoirbeek, Radu C. Duca, Eveline Putzeys, Katrien Poels, and Hannelore Bové

Subjects
Epigenomics, 0301 basic medicine, Cell Survival, Surface Properties, Health, Toxicology and Mutagenesis, Carbon nanotubes, lcsh:Industrial hygiene. Industrial welfare, Bronchi, Toxicology, Proto-Oncogene Mas, Cell Line, Epigenesis, Genetic, Structure-Activity Relationship, 03 medical and health sciences, In vitro, lcsh:RA1190-1270, Gene expression, Humans, Epigenetics, Particle Size, Nanomaterials, lcsh:Toxicology. Poisons, Cell Nucleus, DNA methylation, Toxicity, Nanotubes, Carbon, Chemistry, Research, Epithelial Cells, Promoter, General Medicine, Methylation, Cell cycle, Cell biology, 030104 developmental biology, CpG site, carbon nanotubes, gene expression, nuclear uptake, toxicity, epigenetics, epigenomics, genotoxicity, nanoparticles, nanomaterials, in vitro, Nuclear uptake, Nanoparticles, Genotoxicity, lcsh:HD7260-7780.8, Genome-Wide Association Study
Abstract

Background: Subtle DNA methylation alterations mediated by carbon nanotubes (CNTs) exposure might contribute to pathogenesis and disease susceptibility. It is known that both multi-walled carbon nanotubes (MWCNTs) and single-walled carbon nanotubes (SWCNTs) interact with nucleus. Such, nuclear-CNT interaction may affect the DNA methylation effects. In order to understand the epigenetic toxicity, in particular DNA methylation alterations, of SWCNTs and short MWCNTs, we performed global/genome-wide, gene-specific DNA methylation and RNA-expression analyses after exposing human bronchial epithelial cells (16HBE14o-cell line). In addition, the presence of CNTs on/in the cell nucleus was evaluated in a label-free way using femtosecond pulsed laser microscopy. Results: Generally, a higher number of SWCNTs, compared to MWCNTs, was deposited at both the cellular and nuclear level after exposure. Nonetheless, both CNT types were in physical contact with the nuclei. While particle type dependency was noticed for the identified genome-wide and gene-specific alterations, no global DNA methylation alteration on 5-methylcytosine (5-mC) sites was observed for both CNTs. After exposure to MWCNTs, 2398 genes were hypomethylated (at gene promoters), and after exposure to SWCNTs, 589 CpG sites (located on 501 genes) were either hypo-(N = 493 CpG sites) or hypermethylated (N = 96 CpG sites). Cells exposed to MWCNTs exhibited a better correlation between gene promoter methylation and gene expression alterations. Differentially methylated and expressed genes induced changes (MWCNTs > SWCNTs) at different cellular pathways, such as p53 signalling, DNA damage repair and cell cycle. On the other hand, SWCNT exposure showed hypermethylation on functionally important genes, such as SKI proto-oncogene (SKI), glutathione S-transferase pi 1 (GTSP1) and shroom family member 2 (SHROOM2) and neurofibromatosis type I (NF1), which the latter is both hypermethylated and downregulated. Conclusion: After exposure to both types of CNTs, epigenetic alterations may contribute to toxic or repair response. Moreover, our results suggest that the observed differences in the epigenetic response depend on particle type and differential CNT-nucleus interactions. This work was granted by Stichting Tegen Kanker (Foundation Against Cancer), grant agreement no: 2012-218, Project No: 3 M150270. Manosij Ghosh is a postdoctoral fellow of European Respiratory Society RESPIRE (RESPIRE2) grant agreement no: 2014-7310.

Published
2018
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17. Forces Transmission at Structural Group 0/4/2

Author

Fl. Buium and C. Duca

Subjects
Mechanism (engineering), Singularity, Transmission (telecommunications), Group (mathematics), Mathematical analysis, Transmission quality, Connection (vector bundle), Static analysis, Mathematics
Abstract

The paper uses as forces transmission quality index the coefficient’s determinant of the system serving to static analysis without friction. Then it does the connection between this determinants value and the configuration parameter, expressing the length between exterior joints centres. Aided this length, the conditions for a favourable transmission regime, it formulates. It formulates also the driving link rotatability condition for the simplest mechanism, containing the 0/4/2 structural group.

Published
2018
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20. Graphical shapes of the 2ndtype singularities of a 3-RR̠R planar mechanism

Author

I Doroftei, F. Buium, D. Leohchi, and C Duca

Subjects
Computer Science::Robotics, Mechanism (engineering), Singularity, Planar, Structure (category theory), Robot, Gravitational singularity, Workspace, Type (model theory), Topology, Mathematics
Abstract

This paper intends to discuss about singularity curves of 2nd type inside the workspace of a 3RRR planar parallel mechanism used as robot structure. In order to attain this goal we will use certain variation of the links dimensional parameters. This characterization of the mechanism singularities located inside mechanism workspace depends on the dimensional parameters and can be useful in mechanism designing accorded to some functional particularities in the sense that it can help in avoiding singular configurations.

Published
2016
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21. The 033(6R) structural group existence condition in real field

Author

F. Buium and C. Duca

Subjects
Group (mathematics), Mathematical analysis, Zero (complex analysis), Binary number, Gravitational singularity, Point (geometry), Revolute joint, Topology, Link (knot theory), Real field, Mathematics
Abstract

This paper proposes an approach to identify and study the critical configurations of the 6R (033) structural group, based on an new idea, similar to the case of dyad groups. Starting up from the idea that the critical configurations of a structural group correspond to the singularities of the equation system, modeling the velocity problem and the critical positions are obtained when the lines through the binary link joints are concurrent in a point or are parallel. The velocity equation system for the case of 0/3/3 group with revolute joints, in conditions that the (6x6) system determinant equals zero.

Published
2016
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22. The singularities, forces transmission index and mechanism selfblocking

Author

F. Buium and C. Duca

Subjects
Field (physics), 0211 other engineering and technologies, 02 engineering and technology, Kinematics, 021001 nanoscience & nanotechnology, Transmission index, Mechanism (engineering), Classical mechanics, Position (vector), Component (UML), 021105 building & construction, Gravitational singularity, 0210 nano-technology, Statics, Mathematics
Abstract

The paper represents a synthesis of the most representative results obtained by authors, along their researches in the field of mechanism singularities, forces transmission quality in mechanisms and self-blocking phenomenon. Our research is based on the idea that mechanism critical positions are a consequence of critical configurations in the component structural groups. At its turn, the critical configurations are noticed when the mathematical model of the kinematics and statics without friction, is affected by singularities. Thus, we have presented in the paper, the case of the principal structural groups, and we have established the critical configuration, the calculus formula of the configuration parameter and the existence conditions of the configuration (real solutions in the position problem).

Published
2016
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23. Dietary glutamine, glutamic acid and nucleotides increase the carbon turnover (δ13C) on the intestinal mucosa of weaned piglets

Author

A.B. Amorim, D.A. Berto, M.A.D. Saleh, G.M. Miassi, and C. Ducatti

Subjects
additives, intestinal epithelium, pigs, stable isotopes, Animal culture, SF1-1100
Abstract

This study aimed at evaluating the influence of dietary glutamine, glutamic acid and nucleotides on duodenal and jejunal carbon turnover, and on mucosa morphometry of piglets weaned at an age of 21 days. The diets were: additive-free diet – control (C); 1% of glutamine (G); 1% of glutamic acid (GA); and 1% of nucleotides (N). In intestinal mucosa morphometry trial, 65 animals were used. At day 0 (baseline), five animals were slaughtered to determine the villus height (VH), crypt depth (CD), VH : CD ratio and villi density (VD). The remaining 60 animals were allocated into a randomized block design with 4×3 factorial arrangement (four diets: C – control, G – glutamine, GA – glutamic acid and N – nucleotides; three slaughter ages: 7, 14 and 21 days post-weaning) with five piglets slaughtered per treatment. In carbon turnover trial, 123 animals were used. At day 0 (baseline), three animals were slaughtered to quantify the δ13C half-life (T50%) and the 99% carbon substitution (T99%) on intestinal mucosa. The remaining 120 animals were blocked by three weight categories (light, medium and heavy) and, randomly assigned to pen with the same four diets from the previous trial with one piglet slaughtered per weight category per treatment at days 1, 2, 4, 5, 7, 9, 13, 20, 27 and 49 after weaning. Morphometric analyses have yielded no consistent results regarding the action of the evaluated additives, and few reproducible age-related effects. The N diets determined lower T50% values (5.18 days) and T99% (17.21 days) than G and C diets (T50%=7.29, 7.58 days and T99%=24.22, 25.17 days, respectively) in the duodenal mucosa. In jejunum, the N, GA and G diets determined the lowest T50% means (4.9, 6.2 and 6.7 days, respectively) and T99% means (15.34, 21.10 and 21.84 days, respectively) in comparison with C diets (T50%=7.44 and T99%=24.72 days). The inclusion of the additives in the diets of piglets accelerated the carbon turnover in piglets during the post-weaning period. The stable isotopes technique (δ13C) is an important methodology in studies of additives with trophic effects on the intestinal mucosa of the piglets.

Published
2017
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24. Gas Exchanges and Dehydration in Different Intensities of Conditioning in Tifton 85 Bermudagrass: Nutritional Value during Hay Storage

Author

M. Pasqualotto, M. A. Neres, V. F. Guimarães, J. Klein, A. M. Inagaki, and C. Ducati

Subjects
Haymaking, Mower Conditioner, Stomatal Conductance, Bermudagrass, Animal culture, SF1-1100, Animal biochemistry, QP501-801
Abstract

The present study aimed at evaluating the intensity of Tifton 85 conditioning using a mower conditioner with free-swinging flail fingers and storage times on dehydration curve, fungi presence, nutritional value and in vitro digestibility of Tifton 85 bermudagrass hay dry matter (DM). The dehydration curve was determined in the whole plant for ten times until the baling. The zero time corresponded to the plant before cutting, which occurred at 11:00 and the other collections were carried out at 8:00, 10:00, 14:00, and 16:00. The experimental design was randomised blocks with two intensities of conditioning (high and low) and ten sampling times, with five replications. The high and low intensities related to adjusting the deflector plate of the free iron fingers (8 and 18 cm). In order to determine gas exchanges during Tifton 85 bermudagrass dehydration, there were evaluations of mature leaves, which were placed in the upper middle third of each branch before the cutting, at every hour for 4 hours. A portable gas analyser was used by an infrared IRGA (6400xt). The analysed variables were photosynthesis (A), stomatal conductance (gs), internal CO2 concentration (Ci), transpiration (T), water use efficiency (WUE), and intrinsic water use efficiency (WUEi). In the second part of this study, the nutritional value of Tifton 85 hay was evaluated, so randomised blocks were designed in a split plot through time, with two treatments placed in the following plots: high and low intensity of cutting and five different time points as subplots: cutting (additional treatment), baling and after 30, 60, and 90 days of storage. Subsequently, fungi that were in green plants as well as hay were determined and samples were collected from the grass at the cutting period, during baling, and after 30, 60, and 90 days of storage. It was observed that Tifton 85 bermudagrass dehydration occurred within 49 hours, so this was considered the best time for drying hay. Gas exchanges were more intense before cutting, although after cutting they decreased until ceasing within 4 hours. The lowest values of acid detergent insoluble nitrogen were obtained with low conditioning intensity after 30 days of storage, 64.8 g/kg DM. The in vitro dry matter of Tifton 85 bermudagrass did not differ among the storage times or the conditioning intensities. There was no fungi present in the samples collected during the storage period up to 90 days after dehydration, with less than 30 colony forming units found on plate counting. The use of mower conditioners in different intensities of injury did not speed up the dehydration time of Tifton 85.

Published
2015
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25. Turnover do carbono em sangue e plasma, nas fases crescimento e postura, de codornas japonesas (Coturnix coturnix japonica)

Author

G.E.M. Pimenta, J.C. Denadai, M.M.P. Sartori, A.C. Pezzato, J.R. Sartori, E.A. Garcia, A.N.D. Ishizuka, F.G. Luiggi, R. Fasanaro, G.A.M. Pasquali, E.T. Silva, and C. Ducatti

Subjects
codornas japonesas, farinha de origem animal, plantas C3, plantas C4, patamar de equilíbrio, Animal culture, SF1-1100
Abstract

O estudo objetivou avaliar o turnover do 13C no sangue e plasma de codornas japonesas utilizando a técnica de isótopos estáveis, para a obtenção do patamar de equilíbrio isotópico que servirá de fundamento para estudos de rastreabilidade. Foram utilizadas 300 aves durante o período experimental de 1-42 e 49-97 dias de idade. Os tratamentos da primeira fase foram constituídos de dietas à base de arroz (C3), contendo ou não farinha de carne e ossos bovinos e um com dieta à base de milho (C4). Nessa primeira fase foi analisado o turnover do sinal isotópico do matrizeiro à base de dietas C4 para dietas à base de C3, como também as diferenças isotópicas das dietas contendo ou não farinha de origem animal. Na segunda fase houve uma substituição de dietas, ou seja, as aves no tratamento C4 da primeira fase passaram a consumir dieta C3, e o tratamento que antes consumia dieta C3 passou para dieta C4. Para determinar a taxa de turnover e o percentual estimado de participação da farinha na composição do material coletado, foi empregado o modelo de diluição isotópica utilizando valores do δ13C. A comparação entre as meias-vidas do sangue e plasma da primeira fase revelou o enriquecimento do δ13C na dieta; já na segunda fase foi possível observar as velocidades de incorporação após a troca das dietas.

Published
2014
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30. Differences in MWCNT- and SWCNT-induced DNA methylation alterations in association with the nuclear deposition

Author

Deniz Öner, Manosij Ghosh, Hannelore Bové, Matthieu Moisse, Bram Boeckx, Radu C. Duca, Katrien Poels, Katrien Luyts, Eveline Putzeys, Kirsten Van Landuydt, Jeroen AJ Vanoirbeek, Marcel Ameloot, Diether Lambrechts, Lode Godderis, and Peter HM Hoet

Subjects
Carbon nanotubes, DNA methylation, Gene expression, Nuclear uptake, Toxicity, Epigenetics, Toxicology. Poisons, RA1190-1270, Industrial hygiene. Industrial welfare, HD7260-7780.8
Abstract

Abstract Background Subtle DNA methylation alterations mediated by carbon nanotubes (CNTs) exposure might contribute to pathogenesis and disease susceptibility. It is known that both multi-walled carbon nanotubes (MWCNTs) and single-walled carbon nanotubes (SWCNTs) interact with nucleus. Such, nuclear-CNT interaction may affect the DNA methylation effects. In order to understand the epigenetic toxicity, in particular DNA methylation alterations, of SWCNTs and short MWCNTs, we performed global/genome-wide, gene-specific DNA methylation and RNA-expression analyses after exposing human bronchial epithelial cells (16HBE14o- cell line). In addition, the presence of CNTs on/in the cell nucleus was evaluated in a label-free way using femtosecond pulsed laser microscopy. Results Generally, a higher number of SWCNTs, compared to MWCNTs, was deposited at both the cellular and nuclear level after exposure. Nonetheless, both CNT types were in physical contact with the nuclei. While particle type dependency was noticed for the identified genome-wide and gene-specific alterations, no global DNA methylation alteration on 5-methylcytosine (5-mC) sites was observed for both CNTs. After exposure to MWCNTs, 2398 genes were hypomethylated (at gene promoters), and after exposure to SWCNTs, 589 CpG sites (located on 501 genes) were either hypo- (N = 493 CpG sites) or hypermethylated (N = 96 CpG sites). Cells exposed to MWCNTs exhibited a better correlation between gene promoter methylation and gene expression alterations. Differentially methylated and expressed genes induced changes (MWCNTs > SWCNTs) at different cellular pathways, such as p53 signalling, DNA damage repair and cell cycle. On the other hand, SWCNT exposure showed hypermethylation on functionally important genes, such as SKI proto-oncogene (SKI), glutathione S-transferase pi 1 (GTSP1) and shroom family member 2 (SHROOM2) and neurofibromatosis type I (NF1), which the latter is both hypermethylated and downregulated. Conclusion After exposure to both types of CNTs, epigenetic alterations may contribute to toxic or repair response. Moreover, our results suggest that the observed differences in the epigenetic response depend on particle type and differential CNT-nucleus interactions.

Published
2018
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31. Amphibians of Santa Teresa, Brazil: the hotspot further evaluated.

Author

Ferreira RB, Mônico AT, da Silva ET, Lirio FCF, Zocca C, Mageski MM, Tonini JFR, Beard KH, Duca C, and Silva-Soares T

Abstract

A checklist of the amphibians of Santa Teresa municipality, in southeastern Brazil is presented based on fieldwork, examination of specimens in collections, and a literature review. This new amphibian list of Santa Teresa includes 108 species, of which 106 (~98%) belong to Anura and two (~2%) to Gymnophiona. Hylidae was the most represented family with 47 species (43%). Compared to the previous amphibian lists for Santa Teresa, 14 species were added, 17 previously reported species were removed, and 13 species were re-identified based on recent taxonomic rearrangements. Of the 14 species added, 11 (79%) were first recorded during our fieldwork and specimen examination. It is also the first list of caecilians for Santa Teresa. This list suggests that Santa Teresa has 0.16 species per km 2 (i.e., 108 species/683 km 2 ), one of the highest densities of amphibian species in the world at a regional scale. This richness represents 78% of the 136 anurans from Espírito Santo state and 10% of the 1,080 amphibians from Brazil. We highlight the need for long-term monitoring to understand population trends and develop effective conservation plans to safeguard this remarkable amphibian richness.

Published
2019
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32. Positive roadside edge effects on artificial nest survival in a lowland Atlantic Forest.

Author

da Silva GR, Diniz P, Banhos A, and Duca C

Abstract

Road construction is considered to be one of the primary causes of forest fragmentation, and little is known about how roads affect bird reproductive success. The objective of this study was to assess the survival rate of artificial nests along an edge associated with a highway and in the interior of a tabuleiro forest. The study was performed at the Sooretama Biological Reserve, on the margins of federal highway BR-101, between September and October 2015. A total of 168 artificial nests with a Common quail ( Coturnix coturnix ) egg in each nest were placed along six sampling transects, at distances of 2, 25, 50, 100, 200, 400, and 800 m from the highway toward the forest interior. We used logistic regression and estimated daily survival rate (DSR) using the "Nest Survival" function in the program MARK to estimate artificial nest survival and assessed the effect of the distance from the highway. The artificial nest survival rate was significantly higher on the highway margins than at other distances. The results show that artificial nests located up to 25 m from the highway have a greater success probability (over 95%) and a significant decrease in success probability more than 50 m from the highway. Although we cannot rule out other nonroad-specific edge effects on artificial nest predation, our results suggest that the impacts of the highway (e.g., noise, vibration, visual stimuli) cause predators to avoid the road's surroundings (up to 25 m into the forest) when selecting their feeding sites, which partially supports the predation release hypothesis., Competing Interests: None declared.

Published
2019
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33. ATLANTIC BIRD TRAITS: a data set of bird morphological traits from the Atlantic forests of South America.

Author

Rodrigues RC, Hasui É, Assis JC, Pena JCC, Muylaert RL, Tonetti VR, Martello F, Regolin AL, Costa TVVD, Pichorim M, Carrano E, Lopes LE, de Vasconcelos MF, Fontana CS, Roos AL, Gonçalves F, Banks-Leite C, Cavarzere V, Efe MA, Alves MAS, Uezu A, Metzger JP, de Tarso Zuquim de Antas P, de Barros Ferraz KMPM, Calsavara LC, Bispo AA, Araujo HFP, Duca C, Piratelli AJ, Naka LN, Dias RA, Gatto CAFR, Vallejos MAV, Menezes GDR, Bugoni L, Rajão H, Zocche JJ, Willrich G, Silva ESD, Manica LT, de Camargo Guaraldo A, Althmann G, Serafini PP, Francisco MR, Lugarini C, Machado CG, Marques-Santos F, Bobato R, de Souza EA, Donatelli RJ, Ferreira CD, Morante-Filho JC, Paes-Macarrão ND, Macarrão A, Lima MR, Jacoboski LI, Candia-Gallardo C, Alegre VB, Jahn AE, de Camargo Barbosa KV, Cestari C, Silva JND, Silveira NSD, Crestani ACV, Petronetto AP, Bovo AAA, Viana AD, Araujo AC, Santos AHD, Amaral ACAD, Ferreira A, Vieira-Filho AH, Ribeiro BC, Missagia CCC, Bosenbecker C, Medolago CAB, Espínola CRR, Faxina C, Nunes CEC, Prates C, Luz DTAD, Moreno DJ, Mariz D, Faria D, Meyer D, Doná EA, Alexandrino ER, Fischer E, Girardi F, Giese FB, Shibuya FLS, Faria FA, de Farias FB, de Lima Favaro F, Freitas FJF, Chaves FG, Las-Casas FMG, Rosa GLM, Torre GM, Bochio GM, Bonetti GE, Kohler G, Toledo-Lima GS, Plucenio GP, Menezes Í, Torres IMD, Provinciato ICC, Viana IR, Roper JJ, Persegona JE, Barcik JJ, Martins-Silva J, Just JPG, Tavares-Damasceno JP, de Almeida Ferreira JR, Rosoni JRR, Falcon JET, Schaedler LM, Mathias LB, Deconto LR, Rodrigues LDC, Meyer MAP, Repenning M, Melo MA, de Carvalho MAS, Rodrigues M, Nunes MFC, Ogrzewalska MH, Gonçalves ML, Vecchi MB, Bettio M, Baptista MNDM, Arantes MS, Ruiz NL, de Andrade PGB, Ribeiro PHL, Junior PMG, Macario P, de Oliveira Fratoni R, Meurer R, Saint-Clair RS, Romagna RS, Lacerda RCA, Cerboncini RAS, Lyra RB, Lau R, Rodrigues RC, Faria RR, Laps RR, Althoff SL, de Jesus S, Namba S, Braga TV, Molin T, Câmara TPF, Enedino TR, Wischhoff U, de Oliveira VC, Leandro-Silva V, Araújo-Lima V, de Oliveira Lunardi V, de Gusmão RF, de Souza Correia JM, Gaspar LP, Fonseca RCB, Neto PAFP, de Aquino ACMM, de Camargo BB, Cezila BA, Costa LM, Paolino RM, Kanda CZ, Monteiro ECS, Oshima JEF, Alves-Eigenheer M, Pizo MA, Silveira LF, Galetti M, and Ribeiro MC

Abstract

Scientists have long been trying to understand why the Neotropical region holds the highest diversity of birds on Earth. Recently, there has been increased interest in morphological variation between and within species, and in how climate, topography, and anthropogenic pressures may explain and affect phenotypic variation. Because morphological data are not always available for many species at the local or regional scale, we are limited in our understanding of intra- and interspecies spatial morphological variation. Here, we present the ATLANTIC BIRD TRAITS, a data set that includes measurements of up to 44 morphological traits in 67,197 bird records from 2,790 populations distributed throughout the Atlantic forests of South America. This data set comprises information, compiled over two centuries (1820-2018), for 711 bird species, which represent 80% of all known bird diversity in the Atlantic Forest. Among the most commonly reported traits are sex (n = 65,717), age (n = 63,852), body mass (n = 58,768), flight molt presence (n = 44,941), molt presence (n = 44,847), body molt presence (n = 44,606), tail length (n = 43,005), reproductive stage (n = 42,588), bill length (n = 37,409), body length (n = 28,394), right wing length (n = 21,950), tarsus length (n = 20,342), and wing length (n = 18,071). The most frequently recorded species are Chiroxiphia caudata (n = 1,837), Turdus albicollis (n = 1,658), Trichothraupis melanops (n = 1,468), Turdus leucomelas (n = 1,436), and Basileuterus culicivorus (n = 1,384). The species recorded in the greatest number of sampling localities are Basileuterus culicivorus (n = 243), Trichothraupis melanops (n = 242), Chiroxiphia caudata (n = 210), Platyrinchus mystaceus (n = 208), and Turdus rufiventris (n = 191). ATLANTIC BIRD TRAITS (ABT) is the most comprehensive data set on measurements of bird morphological traits found in a biodiversity hotspot; it provides data for basic and applied research at multiple scales, from individual to community, and from the local to the macroecological perspectives. No copyright or proprietary restrictions are associated with the use of this data set. Please cite this data paper when the data are used in publications or teaching and educational activities., (© 2019 The Authors. Ecology © 2019 The Ecological Society of America.)

Published
2019
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34. ATLANTIC BIRDS: a data set of bird species from the Brazilian Atlantic Forest.

Author

Hasui É, Metzger JP, Pimentel RG, Silveira LF, Bovo AADA, Martensen AC, Uezu A, Regolin AL, Bispo de Oliveira AÂ, Gatto CAFR, Duca C, Andretti CB, Banks-Leite C, Luz D, Mariz D, Alexandrino ER, de Barros FM, Martello F, Pereira IMDS, da Silva JN, Ferraz KMPMDB, Naka LN, Dos Anjos L, Efe MA, Pizo MA, Pichorim M, Gonçalves MSS, Cordeiro PHC, Dias RA, Muylaert RDL, Rodrigues RC, da Costa TVV, Cavarzere V, Tonetti VR, Silva WR, Jenkins CN, Galetti M, and Ribeiro MC

Abstract

South America holds 30% of the world's avifauna, with the Atlantic Forest representing one of the richest regions of the Neotropics. Here we have compiled a data set on Brazilian Atlantic Forest bird occurrence (150,423) and abundance samples (N = 832 bird species; 33,119 bird individuals) using multiple methods, including qualitative surveys, mist nets, point counts, and line transects). We used four main sources of data: museum collections, on-line databases, literature sources, and unpublished reports. The data set comprises 4,122 localities and data from 1815 to 2017. Most studies were conducted in the Florestas de Interior (1,510 localities) and Serra do Mar (1,280 localities) biogeographic sub-regions. Considering the three main quantitative methods (mist net, point count, and line transect), we compiled abundance data for 745 species in 576 communities. In the data set, the most frequent species were Basileuterus culicivorus, Cyclaris gujanensis, and Conophaga lineata. There were 71 singletons, such as Lipaugus conditus and Calyptura cristata. We suggest that this small number of records reinforces the critical situation of these taxa in the Atlantic Forest. The information provided in this data set can be used for macroecological studies and to foster conservation strategies in this biodiversity hotspot. No copyright restrictions are associated with the data set. Please cite this Data Paper if data are used in publications and teaching events., (© 2017 by the Ecological Society of America.)

Published
2018
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35. Effects of inorganics on the degradation of micropollutants with vacuum UV (VUV) advanced oxidation.

Author

Duca C, Imoberdorf G, and Mohseni M

Subjects
Bicarbonates chemistry, Hydrogen Peroxide chemistry, Hydroxyl Radical chemistry, Nitrates chemistry, Oxidation-Reduction, Photolysis, Sulfates chemistry, Atrazine analysis, Inorganic Chemicals chemistry, Models, Theoretical, Ultraviolet Rays, Vacuum, Water Pollutants, Chemical analysis
Abstract

This research focused on the effects of inorganic water constituents on the efficiency of vacuum UV (VUV) for the degradation of micropollutants in surface water supplies. Atrazine was used as a model miropollutant, and bicarbonate, sulphate, and nitrate were used as the most common inorganic constituents in the water matrix. First, the absorbance of radiation at 254 and 185 nm was measured in the presence of different ions. At 254 nm, only nitrate showed a measurable absorption coefficient of [Formula: see text] = 3.51 M[Formula: see text] cm[Formula: see text], and all other ions showed a molar absorption coefficient below the detection limit. However, at 185 nm, all the ions showed high absorption coefficients, with nitrate giving the highest absorption coefficient of [Formula: see text] = 5568 M[Formula: see text] cm[Formula: see text]. Second, the hydroxyl radical (HO[Formula: see text]) scavenging effects of the same inorganic ions were evaluated; nitrate and bicarbonate showed a negative effect during the UV/H 2 O 2 and VUV advanced oxidation processes. Sulfate was photolyzed with 185 nm UV to form HO[Formula: see text], and for this reason, it assisted the degradation of the target micropollutant, as demonstrated by increases in the degradation rate constant. An additional component of this work involved developing a method for measuring the quantum yield of atrazine at 185 nm. This made it possible to distinguish the contribution of OH radical attach from that of direct photolysis towards the degradation of atrazine.

Published
2017
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36. Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report.

Author

Nussbaum-Hermassi L, Ahle G, Zaenker C, Duca C, and Namer IJ

Subjects
Evoked Potentials, Visual physiology, Female, Humans, Indium Radioisotopes, Magnetic Resonance Imaging, Meningioma complications, Meningioma metabolism, Meningioma physiopathology, Middle Aged, Multimodal Imaging, Optic Nerve Neoplasms complications, Optic Nerve Neoplasms metabolism, Optic Nerve Neoplasms physiopathology, Receptors, Somatostatin metabolism, Scotoma etiology, Single Photon Emission Computed Tomography Computed Tomography, Somatostatin analogs & derivatives, Vision Disorders etiology, Meningioma diagnostic imaging, Optic Nerve Neoplasms diagnostic imaging
Abstract

Background: Optic nerve sheath meningiomas account for only 2% of orbital lesions and 42% of optic nerve tumors. Diagnosis remains difficult because histologic confirmation carries a high risk of visual loss. Therefore, a less invasive and specific diagnostic method for differentiating optic nerve sheath meningiomas from other optic nerve lesions is needed to overcome the limitations of computed tomography and magnetic resonance imaging, and make the best individualized treatment decision. This case is a good illustration of the clinical and imaging difficulties inherent in this rare tumor, which may be hard to differentiate from other causes., Case Presentation: A 51-year-old Caucasian woman developed a central scotoma, visual loss, and abnormal visual evoked potentials. The first magnetic resonance imaging scan classified the optic nerve damage as retrobulbar optic neuritis. After magnetic resonance imaging follow-up at 3 months, a negative lumbar puncture and biological workup, and clinical worsening, an optic nerve sheath meningioma was suspected. We confirmed this diagnosis with 111In-pentetreotide single-photon emission computed tomography, which is able to bind with very high affinity to somatostatin receptor subtype 2 expressed on meningiomas., Conclusions: In the diagnosis of optic nerve sheath meningiomas, [111In]-pentetreotide single-photon emission computed tomography-fused magnetic resonance imaging is a valuable additional tool, optimizing the diagnosis and obviating the need for a more invasive procedure.

Published
2016
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