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2. Correction: Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

Author

Duse, Marzia, Santamaria, Francesca, Verga, Maria Carmen, Bergamini, Marcello, Simeone, Giovanni, Leonardi, Lucia, Tezza, Giovanna, Bianchi, Annamaria, Capuano, Annalisa, Cardinale, Fabio, Cerimoniale, Giovanni, Landi, Massimo, Malventano, Monica, Tosca, Mariangela, Varricchio, Attilio, Zicari, Anna Maria, Alfaro, Carlo, Barberi, Salvatore, Becherucci, Paolo, Bernardini, Roberto, Biasci, Paolo, Caffarelli, Carlo, Caldarelli, Valeria, Capristo, Carlo, Castronuovo, Serenella, Chiappini, Elena, Cutrera, Renato, De Castro, Giovanna, De Franciscis, Luca, Decimo, Fabio, Iacono, Iride Dello, Diaferio, Lucia, Di Cicco, Maria Elisa, Di Mauro, Caterina, Di Mauro, Cristina, Di Mauro, Dora, Di Mauro, Francesco, Di Mauro, Gabriella, Doria, Mattia, Falsaperla, Raffaele, Ferraro, Valentina, Fanos, Vassilios, Galli, Elena, Ghiglioni, Daniele Giovanni, Indinnimeo, Luciana, Kantar, Ahmad, Lamborghini, Adima, Licari, Amelia, Lubrano, Riccardo, Luciani, Stefano, Macrì, Francesco, Marseglia, Gianluigi, Martelli, Alberto Giuseppe, Masini, Luigi, Midulla, Fabio, Minasi, Domenico, Miniello, Vito Leonardo, Del Giudice, Michele Miraglia, Morandini, Sergio Renzo, Nardini, Germana, Nocerino, Agostino, Novembre, Elio, Pajno, Giovanni Battista, Paravati, Francesco, Piacentini, Giorgio, Piersantelli, Cristina, Pozzobon, Gabriella, Ricci, Giampaolo, Spanevello, Valter, Turra, Renato, Zanconato, Stefania, Borrelli, Melissa, Villani, Alberto, Corsello, Giovanni, Di Mauro, Giuseppe, and Peroni, Diego

Published
2022
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3. Impact of intrauterine growth restriction on cerebral and renal oxygenation and perfusion during the first 3 days after birth

Author

Montaldo, Paolo, Puzone, Simona, Caredda, Elisabetta, Pugliese, Umberto, Inserra, Emanuela, Cirillo, Grazia, Gicchino, Francesca, Campana, Giuseppina, Ursi, Davide, Galdo, Francesca, Internicola, Margherita, Spagnuolo, Ferdinando, Carpentieri, Mauro, Capristo, Carlo, Marzuillo, Pierluigi, and Del Giudice, Emanuele Miraglia

Published
2022
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4. Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy

Author

Montaldo, Paolo, primary, Burgod, Constance, additional, Herberg, Jethro A., additional, Kaforou, Myrsini, additional, Cunnington, Aubrey J., additional, Mejias, Asuncion, additional, Cirillo, Grazia, additional, Miraglia Del Giudice, Emanuele, additional, Capristo, Carlo, additional, Bandiya, Prathik, additional, Kamalaratnam, Chinnathambi N., additional, Chandramohan, Rema, additional, Manerkar, Swati, additional, Rodrigo, Ranmali, additional, Sumanasena, Samanmali, additional, Krishnan, Vaisakh, additional, Pant, Stuti, additional, Shankaran, Seetha, additional, and Thayyil, Sudhin, additional

Published
2024
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5. Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

Author

Duse, Marzia, Santamaria, Francesca, Verga, Maria Carmen, Bergamini, Marcello, Simeone, Giovanni, Leonardi, Lucia, Tezza, Giovanna, Bianchi, Annamaria, Capuano, Annalisa, Cardinale, Fabio, Cerimoniale, Giovanni, Landi, Massimo, Malventano, Monica, Tosca, Mariangela, Varricchio, Attilio, Zicari, Anna Maria, Alfaro, Carlo, Barberi, Salvatore, Becherucci, Paolo, Bernardini, Roberto, Biasci, Paolo, Caffarelli, Carlo, Caldarelli, Valeria, Capristo, Carlo, Castronuovo, Serenella, Chiappini, Elena, Cutrera, Renato, De Castro, Giovanna, De Franciscis, Luca, Decimo, Fabio, Iacono, Iride Dello, Diaferio, Lucia, Di Cicco, Maria Elisa, Di Mauro, Caterina, Di Mauro, Cristina, Di Mauro, Dora, Di Mauro, Francesco, Di Mauro, Gabriella, Doria, Mattia, Falsaperla, Raffaele, Ferraro, Valentina, Fanos, Vassilios, Galli, Elena, Ghiglioni, Daniele Giovanni, Indinnimeo, Luciana, Kantar, Ahmad, Lamborghini, Adima, Licari, Amelia, Lubrano, Riccardo, Luciani, Stefano, Macrì, Francesco, Marseglia, Gianluigi, Martelli, Alberto Giuseppe, Masini, Luigi, Midulla, Fabio, Minasi, Domenico, Miniello, Vito Leonardo, del Giudice, Michele Miraglia, Morandini, Sergio Renzo, Nardini, Germana, Nocerino, Agostino, Novembre, Elio, Pajno, Giovanni Battista, Paravati, Francesco, Piacentini, Giorgio, Piersantelli, Cristina, Pozzobon, Gabriella, Ricci, Giampaolo, Spanevello, Valter, Turra, Renato, Zanconato, Stefania, Borrelli, Melissa, Villani, Alberto, Corsello, Giovanni, Di Mauro, Giuseppe, and Peroni, Diego

Published
2021
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7. Critical reappraisal of short-acting bronchodilators for pediatric respiratory diseases.

Author

Licari, Amelia, Manti, Sara, Mastellone, Francesco, Miraglia Del Giudice, Michele, Marseglia, Gian Luigi, Tosca, Maria Angela, Andrenacci, Beatrice, Capristo, Carlo, Cutrera, Renato, Di Cicco, Maria Elisa, Fierro, Vincenzo, Leone, Maddalena, Naso, Matteo, Pezone, Ilaria, and Trincianti, Chiara

Subjects
PARASYMPATHOMIMETIC agents, HEALTH literacy, RESPIRATORY organ sounds, PATIENT safety, BRONCHIOLE diseases, RESPIRATORY diseases, TREATMENT duration, TREATMENT effectiveness, PEDIATRICS, BRONCHODILATOR agents, ASTHMA, CHILDREN
Abstract

Short-acting bronchodilators are a class of medications commonly used to treat asthma, chronic obstructive pulmonary disease, and other respiratory conditions. The use of these medications has evolved over time as we have gained a better understanding of their effectiveness and safety in the pediatric population. This comprehensive review synthesizes the current understanding of short-acting β2-agonists and short-acting anticholinergics in children. It addresses indications, contraindications, safety considerations, and highlights areas where further research is needed to guide the most effective use of short-acting bronchodilators. [ABSTRACT FROM AUTHOR]

Published
2024
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10. From Clinical Scenarios to the Management of Lower Urinary Tract Symptoms in Children: A Focus for the General Pediatrician

Author

Palma, Pier Luigi, primary, Marzuillo, Pierluigi, additional, Di Sessa, Anna, additional, Guarino, Stefano, additional, Capalbo, Daniela, additional, Marrapodi, Maria Maddalena, additional, Buccella, Giulia, additional, Cameli, Sabrina, additional, Miraglia del Giudice, Emanuele, additional, Torella, Marco, additional, Colacurci, Nicola, additional, and Capristo, Carlo, additional

Published
2023
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12. Magnetic Resonance Biomarkers and Neurological Outcome of Infants with Mild Hypoxic-Ischaemic Encephalopathy Who Progress to Moderate Hypoxic-Ischaemic Encephalopathy

Author

Montaldo, Paolo, primary, Puzone, Simona, additional, Caredda, Elisabetta, additional, Galdo, Francesca, additional, Pugliese, Umberto, additional, Maietta, Anna, additional, Ascione, Serena, additional, Diplomatico, Mario, additional, Spagnuolo, Ferdinando, additional, Roma, Vincenzina, additional, De Vivo, Massimiliano, additional, Carpentieri, Mauro, additional, Moschella, Sabino, additional, Giordano, Lucio, additional, D’Amico, Alessandra, additional, Capristo, Carlo, additional, Travan, Laura, additional, Chello, Giovanni, additional, Miraglia del Giudice, Emanuele, additional, and Cirillo, Mario, additional

Published
2022
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14. A Survey on the Management of Children with Asthma in Primary Care Setting in Italy

Author

Tosca, Maria Angela, Schiavetti, Irene, Duse, Marzia, Maseglia, Gian Luigi, Ciprandi, Giorgio, Licari, Amelia, Leone, Maddalena, Di Cicco, Maria Elisa, Bozzetto, Sara, De Vittori, Valentina, Scavone, Maria, Amato, Doriana, Capristo, Carlo, and Di Mauro, Dora

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Primary Health Care, business.industry, MEDLINE, Primary care, medicine.disease, Asthma, Italy, Surveys and Questionnaires, Family medicine, Pediatrics, Perinatology and Child Health, medicine, Humans, Immunology and Allergy, My Corner: Allergy and Pulmonary Highlights from Around the World, Child, business
Published
2021

15. Characterization and Comparison of Ocular Surface Microbiome in Newborns

Author

Petrillo, Francesco, primary, Petrillo, Arianna, additional, Marrapodi, Maddalena, additional, Capristo, Carlo, additional, Gicchino, Maria Francesca, additional, Montaldo, Paolo, additional, Caredda, Elisabetta, additional, Reibaldi, Michele, additional, Boatti, Lara M. V., additional, Dell’Annunziata, Federica, additional, Folliero, Veronica, additional, and Galdiero, Marilena, additional

Published
2022
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16. Magnetic Resonance Biomarkers and Neurological Outcome of Infants with Mild Hypoxic-Ischaemic Encephalopathy Who Progress to Moderate Hypoxic-Ischaemic Encephalopathy.

Author

Montaldo, Paolo, Puzone, Simona, Caredda, Elisabetta, Galdo, Francesca, Pugliese, Umberto, Maietta, Anna, Ascione, Serena, Diplomatico, Mario, Spagnuolo, Ferdinando, Roma, Vincenzina, De Vivo, Massimiliano, Carpentieri, Mauro, Moschella, Sabino, Giordano, Lucio, D'Amico, Alessandra, Capristo, Carlo, Travan, Laura, Chello, Giovanni, Miraglia del Giudice, Emanuele, and Cirillo, Mario

Subjects
MAGNETIC resonance, INFANTS, BRAIN diseases, MAGNETIC resonance imaging, THERAPEUTIC hypothermia
Abstract

Background: There is increasing concern that infants with mild hypoxic-ischaemic encephalopathy (HIE) may develop seizures and progress to moderate HIE beyond the therapeutic window for cooling. Objective: The aim of this study was to examine the effect of therapeutic hypothermia on magnetic resonance imaging (MRI) biomarkers and neurological outcomes in infants with mild HIE and seizures within 24 h after birth. Methods: This study shows an observational cohort study on 366 (near)-term infants with mild HIE and normal amplitude-integrated electroencephalography background. Results: Forty-one infants showed progression (11.2%); 29/41 (70.7%) were cooled. Infants with progression showed cerebral metabolite perturbations and higher white matter injury scores compared to those without in both cooled and non-cooled groups (p = 0.001, p = 0.02). Abnormal outcomes were seen in 5/12 (42%) non-cooled and 7/29 (24%) cooled infants with progression (p = 0.26). Conclusions: Early biomarkers are needed to identify infants with mild HIE at risk of progression. Mild HIE infants with progression showed a higher incidence of brain injury and abnormal outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Comorbidità nell’asma grave pediatrico

Author

Licari, Amelia, Andrenacci, Beatrice, Bozzetto, Sara, Capristo, Carlo, De Vittori, Valentina, Di Cicco, Maria Elisa, Di Mauro, Dora, Leone, Maddalena, Scavone, Maria, and Tosca, Maria Angela

Subjects
severe asthma, pediatrics, precision medicine, severe asthma, comorbidities, precision medicine, pediatrics, comorbidities
Published
2022

20. Maternal and Fetal Outcomes in Women with Diabetes in Pregnancy Treated before and after the Introduction of a Standardized Multidisciplinary Management Protocol

Author

Morlando, Maddalena, primary, Savoia, Fabiana, additional, Conte, Anna, additional, Schiattarella, Antonio, additional, La Verde, Marco, additional, Petrizzo, Michela, additional, Carpentieri, Mauro, additional, Capristo, Carlo, additional, Esposito, Katherine, additional, and Colacurci, Nicola, additional

Published
2021
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21. Safety and effectiveness of intranasal dexmedetomidine together with midazolam for sedation in neonatal MRI

Author

Inserra, Emanuela, primary, Colella, Umberto, additional, Caredda, Elisabetta, additional, Diplomatico, Mario, additional, Puzone, Simona, additional, Moschella, Sabino, additional, Capristo, Carlo, additional, Tedeschi, Gioacchino, additional, Caranci, Ferdinando, additional, Cirillo, Mario, additional, Miraglia del Giudice, Emanuele, additional, and Montaldo, Paolo, additional

Published
2021
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24. Controversie nel trattamento dell’asma lieve: quali novità e implicazioni pratiche

Author

Tosca, Maria Angela, Bozzetto, Sara, Capristo, Carlo, De Vittori, Valentina, Di Cicco, Maria Elisa, Di Mauro, Dora, Leone, Maddalena, Scavone, Maria, and Licari, Amelia

Subjects
asma, controllo, broncodilatator, gravità, asma, bambini, gravità, controllo, corticosteroidi inalatori, broncodilatator, bambini, corticosteroidi inalatori
Published
2021

28. Impact of Braxton-Hicks contractions on fetal wellbeing; a prospective analysis through computerised cardiotocography.

Author

La Verde, Marco, Riemma, Gaetano, Torella, Marco, Torre, Clelia, Cianci, Stefano, Conte, Anna, Capristo, Carlo, Morlando, Maddalena, Colacurci, Nicola, and De Franciscis, Pasquale

Subjects
FETAL heart rate monitoring, HEART beat, PREGNANT women, MOTHERS, UTERINE contraction
Abstract

To estimate the correlation between the maternal perception of Braxton-Hicks contractions (BHC) and foetal wellbeing throughout antepartum computerised cardiotocography (cCTG) parameters, we performed a prospective observational study between April 2019 and March 2020. Non-labouring women with a term pregnancy were recruited. We collected data regarding maternal perception of BHC in the last two weeks before delivery. For each patient, an external computerised cardiotocography (cCTG) was registered. Women were subdivided in accordance with perception or non-perception of BHC. Fifty women were recruited. Women who felt BHC showed higher foetal heart rate (135 bpm vs 128 bpm, p =.008), lower long-term variability (47.2 ms vs 57.7 ms, p =.02) and reduced number of accelerations (7.8 vs 11.4, p =.04). In conclusion, the absence of mother's perception of BHC showed lower baseline foetal heart rate, increased number of accelerations and higher long-term variability related to mothers who perceived BHC. What is already known on this subject? BHC are common painful contractions that start in the third trimester. They are random spots of uterine action that happen in the absence of sufficient gap-junction connectivity. BHC have a significant impact on foetal wellbeing. What do the results of this study add? BHC are associated with reduced long-term variability during cCTG examination. Moreover, baseline foetal heart rate seems lower, and accelerations are less frequent when BHC are felt by pregnant women. What are the implications of these findings for clinical practice and/or further research? These findings could be related to a cumulative effect on the uterine flow mediated by BHC. Further researches are needed to state the impact of BHC on the foetal wellbeing. [ABSTRACT FROM AUTHOR]

Published
2022
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31. CONSENSUS INTERSOCIETARIA - L’uso dei corticosteroidi inalatori in età evolutiva

Author

Alfaro, Carlo, Barberi, Salvatore, Becherucci, Paolo, Bergamini, Marcello, Bianchi, Anna Maria, Biasci, Paolo, Boner, Attilio, Caffarelli, Carlo, Caldarelli, Valeria, Capristo, Carlo, Capuano, Annalisa, Cardinale, Fabio, Castronuovo, Serenella, Cerimoniale, Giovanni, Chiappini, Elena, Cutrera, Renato, Castro, Giovanna, Franciscis, Luca, Decimo, Fabio, Dello Iacono, Iride, Diaferio, Lucia, Maria Di Cicco, Di Mauro, Caterina, Di Mauro, Cristina, Di Mauro, Dora, Di Mauro, Francesco, Di Mauro, Giuseppe, Doria, Mattia, Duse, Marzia, Falsaperla, Raffaele, Fanos, Vassilios, Ferraro, Valentina, Galli, Elena, Ghiglioni, Daniele Giovanni, Indinnimeo, Luciana, Kantar, Ahmad, Lamborghini, Adima, Landi, Massimo, Leonardi, Lucia, Lubrano, Riccardo, Luciani, Stefano, Macrì, Francesco, Malventano, Monica, Marseglia, Gian Luigi, Martelli, Alberto, Masini, Luigi, Midulla, Fabio, Minasi, Domenico, Miniello, Vito Leonardo, Miraglia Del Giudice, Michele, Morandini, Sergio Renzo, Nardini, Germana, Nocerino, Agostino, Novembre, Elio, Pajno, Giovanni Battista, Paravati, Francesco, Diego Peroni, Piacentini, Giorgio, Piersantelli, Cristina, Pozzobon, Gabriella, Ricci, Gian Paolo, Santamaria, Francesca, Simeone, Giovanni, Spanevello, Valter, Tezza, Giovanna, Tosca, Mariangela, Turra, Renato, Ugazio, Alberto Giovanni, Varricchio, Attilio, Verga, Maria Carmen, Zanconato, Stefania, and Zicari, Anna Maria

Published
2019

32. Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report

Author

Pajno, Giovanni Battista, Bernardini, Roberto, Peroni, Diego, Arasi, Stefania, Martelli, Alberto, Landi, Massimo, Passalacqua, Giovanni, Muraro, Antonella, Grutta, Stefania La, Fiocchi, Alessandro, Indinnimeo, Luciana, Caffarelli, Carlo, Calamelli, Elisabetta, Comberiati, Pasquale, Duse, Marzia, Allergy, Allergen specific Immunotherapy panel of the Italian Society of Pediatric, CAPRISTO, Carlo, Pajno, Giovanni Battista, Bernardini, Roberto, Peroni, Diego, Arasi, Stefania, Martelli, Alberto, Landi, Massimo, Passalacqua, Giovanni, Muraro, Antonella, Grutta, Stefania La, Fiocchi, Alessandro, Indinnimeo, Luciana, Caffarelli, Carlo, Calamelli, Elisabetta, Comberiati, Pasquale, Duse, Marzia, Allergy, Allergen specific Immunotherapy panel of the Italian Society of Pediatric, and Capristo, Carlo

Published
2017

34. Impatto del microbioma (polmonare e intestinale) sull’asma

Author

Maria Di Cicco, Licari, Amelia, Leone, Maddalena, Bozzetto, Sara, Chinellato, Iolanda, Capristo, Carlo, De Vittori Valentina, Severini, Nadia, and Tosca Maria Angela

Subjects
asma, microbioma intestinale, microbioma polmonare, asma, microbioma intestinale, microbioma polmonare
Published
2018

37. Safety and effectiveness of intranasal dexmedetomidine together with midazolam for sedation in neonatal MRI.

Author

Inserra, Emanuela, Colella, Umberto, Caredda, Elisabetta, Diplomatico, Mario, Puzone, Simona, Moschella, Sabino, Capristo, Carlo, Tedeschi, Gioacchino, Caranci, Ferdinando, Cirillo, Mario, Miraglia del Giudice, Emanuele, Montaldo, Paolo, and Cravero, Joseph

Subjects
DEXMEDETOMIDINE, MIDAZOLAM, MAGNETIC resonance imaging, ADRENERGIC agonists
Abstract

Therefore, the ideal sedation regimen should obviate the need for an intravenous access, but still enable the completion of the MRI without deep sedation and subsequent complications. Keywords: adverse effects; dexmedetomidine; infant; magnetic resonance imaging; midazolam EN adverse effects dexmedetomidine infant magnetic resonance imaging midazolam 79 81 3 12/09/21 20220101 NES 220101 Magnetic resonance imaging (MRI) has been consistently indicated as the imaging modality of choice in children and neonates. While feed and wrap technique may be used to perform MRI scans without sedation, this is not always possible due to MRI sensitivity to motion artifacts and long duration of the procedure. [Extracted from the article]

Published
2022
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38. Microorganism-induced exacerbations in atopic dermatitis: a possible preventive role for vitamin D?

Author

Benetti C, Piacentini GL, CAPRISTO, Carlo, Boner AL, Peroni DG, Benetti, C, Piacentini, Gl, Capristo, Carlo, Boner, Al, and Peroni, Dg

Subjects
Staphylococcus aureus, vitamin D, Atopic dermatiti
Abstract

Atopic dermatitis (AD) is a common skin disease characterized by a complex pathogenesis not completely understood despite numerous studies to date. The clinical patterns result from interactions between genetic disorders determining abnormalities in the epidermis differentiation complex, modification of the cutaneous barrier, and dysfunction of immune responses. Several studies have shown that an alteration of the skin barrier combined with immune dysfunction is important for the onset, maintenance, and risk of exacerbations of the disease. In recent years, new aspects regarding the pathogenesis of the disease, such as the effects of vitamin D (VD) on immunity at the skin level and the role of certain microorganisms (particularly Staphylococcus and Malassezia species) on eczema exacerbations, have been evaluated. This article provides an overview of the evidences supporting the link between VD (deficiency) and microorganisms (skin colonization/sensitization) in AD pathogenesis, based on comprehensive review of the literature. By considering different aspects of disease, it might be possible to improve our understanding, particularly in those patients refractory to conventional treatments. An electronic research strategy was used to search in Medline Pub-Med Library using as research words AD, exacerbation, VD, Staphylococcus aureus (SA), and Malassezia. The results were downloaded and analyzed for systematic review. Few studies actually consider the relationship between VD deficiency (VDD), AD, and SA and Malassezia, but many suggest a correlation between these factors. VDs play a major role against microorganisms in the development of AD and should be considered when treating patients.

Published
2015

44. MKRN3 levels in girls with central precocious puberty and correlation with sexual hormone levels: a pilot study.

Author

Grandone, Anna, Cirillo, Grazia, Sasso, Marcella, Capristo, Carlo, Tornese, Gianluca, Marzuillo, Pierluigi, Luongo, Caterina, Rosaria Umano, Giuseppina, Festa, Adalgisa, Coppola, Ruggero, Miraglia del Giudice, Emanuele, and Perrone, Laura

Abstract

Purpose: Recently, mutations of makorin RING-finger protein 3 (MKRN3) have been described in familial central precocious puberty. Serum levels of this protein decline before the pubertal onset in healthy girls and boys. The aim of the study is to investigate MKRN3 circulating levels in patients with central precocious puberty. Methods: We performed an observational cross-sectional study. We enrolled 17 patients with central precocious puberty aged 7 years (range: 2-8 years) and breast development onset <8 years; 17 prepubertal control age-matched patients aged 6.3 years (2-8.2); and 10 pubertal stage-matched control patients aged 11.4 years (9-14). Serum values of MKRN3, gonadotropins, (17)estradiol and Anti-Müllerian Hormone were evaluated and the MKRN3 genotyped in central precocious puberty patients. Results: No MKRN3 mutation was found among central precocious puberty patients. MKRN3 levels were lower in patients with central precocious puberty compared to prepubertal age-matched ones (p: 0.0004) and comparable to those matched for pubertal stage. MKRN3 levels were inversely correlated to Body Mass Index Standard Deviations ( r:−0.35; p:0.02), Luteinizing Hormone ( r:−0.35; p:0.03), FSH ( r:−0.37; p:0.02), and (17)estradiol ( r: −0.36; p:0.02). Conclusions: We showed that girls with central precocious puberty had lower peripheral levels of MKRN3 compared to age-matched pairs and that they negatively correlated to gonadotropins, estrogen, and BMI. Our findings support the MKRN3 involvement in central precocious puberty also in absence of deleterious mutations, although our sample size is small. In addition our data suggest the role of MKRN3 in the complex mechanism controlling puberty onset and its interaction with other factors affecting puberty such as nutrition. [ABSTRACT FROM AUTHOR]

Published
2018
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50. The association between fetal Doppler and uterine artery blood volume flow at term of pregnancy: a pilot study

Author

Marco La Verde, Marco Torella, Carlo Ronsini, Gaetano Riemma, Luigi Cobellis, Maria Maddalena Marrapodi, Carlo Capristo, Agnese Maria Chiara Rapisarda, Maddalena Morlando, Pasquale De Franciscis, La Verde, Marco, Torella, Marco, Ronsini, Carlo, Riemma, Gaetano, Cobellis, Luigi, Marrapodi, Maria Maddalena, Capristo, Carlo, Rapisarda, Agnese Maria Chiara, Morlando, Maddalena, and De Franciscis, Pasquale

Subjects
Radiology, Nuclear Medicine and imaging
Abstract

Purpose: To investigate the relationship between uterine artery blood volume flow and fetal doppler indices at term of pregnancy. Materials and Methods: A prospective observational study in a tertiary-care university hospital was performed between December 2021 and May 2022. We included only term pregnancies that received an accurate ultrasound scan until a week before the birth. Uterine artery (UtA) diameter and UtA volume blood flow was estimated were recorded. The volume of each artery was summed to obtain the total uterine artery volume blood flow (QUtA). Umbilical artery (UA), middle cerebral artery (MCA), ductus venosus (DV) and cerebroplacental ratio (CPR) foetal doppler indices were evaluated. Linear regression analysis was performed to investigate the relation of the QUtA with the fetal Doppler indices. Results: 49 pregnancies were included. UA pulsatility index (PI) analysis showed a significant association with QUtA (r2=0.40, p=0.01), demonstrating a decrease of the UA PI when the QUtA increased. The same relationship was noted between the UtA mean PI and QUtA (r2=0.41, p=0.005). A weak correlation between the newborn weight and the QUtA was also noted (r2=0.31, p=0.048), with an elevated newborn weight when the QUtA was high. Conclusion: This study showed that UA, UtA PI and birth weight seem to be linked to QUtA. QUtA had an inverse correlation with UA and UtA PI. In addition, increasing the QUtA showed a linear increase in fetal birth weight. These findings could be helpful in high-risk pregnancy management, but additional research is needed to identify how QUtA in the third trimester impacts labour and fetal outcomes.

Published
2023

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