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Your search keyword '"CHAN-MUK IM"' showing total 7 results
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7 results on '"CHAN-MUK IM"'

1. Clinical outcomes of colorectal neoplasm with positive resection margin after endoscopic submucosal dissection

Author

Hyung-Hoon Oh, Je-Seong Kim, Jae-Woong Lim, Chae-June Lim, Young-Eun Seo, Ga-Ram You, Chan-Muk Im, Ki-Hyun Kim, Dong-Hyun Kim, Hyun-Soo Kim, and Young-Eun Joo

Subjects
Colorectal tumor, Endoscopic submucosal dissection, Positive margin, Medicine, Science
Abstract

Abstract A positive resection margin after colorectal endoscopic submucosal dissection (ESD) is associated with an increased risk of recurrence. We aimed to identify the clinical significance of positive resection margins in colorectal neoplasms after ESD. We reviewed 632 patients who had en bloc colorectal ESD at two hospitals between 2015 and 2020. The recurrence rates and presence of residual tumor after surgery were evaluated. The rate of additional surgery after ESD and recurrence rate were significantly higher in patients with incomplete resection (n = 75) compared to patients with complete resection (n = 557). When focusing solely on non-invasive lesions, no significant differences in recurrence rates were observed between the groups with complete and incomplete resection (0.2% vs. 1.9%, p = 0.057). Among 84 patients with submucosal invasive carcinoma, 39 patients underwent additional surgery due to non-curative resection. Positive vertical margin and lymphovascular invasion were associated with residual tumor. Lymphovascular invasion was associated with lymph node metastasis. However, no residual tumor nor lymph node metastases were found in patients with only one unfavorable histological factor. In conclusion, a positive resection margin in non-invasive colorectal lesions, did not significantly impact the recurrence rate. Also, in T1 colorectal cancer with a positive vertical resection margin, salvage surgery can be considered in selected patients with additional risk factors.

Published
2024
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2. Primary Esophageal Malignant Melanoma in Korea: Clinical features, Management and Prognosis

Author

Hyung-Hoon Oh, Yong-Wook Jung, Bora Han, Chan-Muk Im, Hyung-Joo Yu, and Young-Eun Joo

Subjects
melanoma, esophagus, korea, Medicine
Abstract

Primary esophageal melanoma is a rare disease with a poor prognosis. To date, 18 cases have been reported in Korea. Four patients visited the Chonnam National University Hwasun Hospital with dysphagia, followed by epigastric pain and discomfort, odynophagia, and weight loss. Esophagogastroduodenoscopy revealed a black pigmented polypoid mass, protruding mass, or black-pigmented flat lesions. Two patients had distant metastases and lymphadenopathies in imaging studies. Two patients underwent esophagectomy and intrathoracic esophagogastrostomy. One patient was treated with chemotherapy and interferon-alpha. The other patient declined further treatment. The routine histology using H&E revealed brown-colored atypical melanocytes. Immunohistochemical staining exhibited strong reactivity for Melan-A, S-100, and HMB-45 proteins. The biopsy specimens were interpreted to be malignant melanoma. One patient had multiple distant metastases 13 months after surgery. The other patient had no recurrence for 33 months after surgery. The patient treated with chemotherapy and interferon-alpha showed disease progression in the follow-up examination. Primary esophageal melanoma in Korea is a rare disease characterized by aggressive behavior, early metastasis, and poor prognosis.

Published
2022
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3. Clinical Outcome and Risk Factors of Chronic Radiation Proctitis Following Pelvic Radiation Therapy

Author

CHAN-MUK IM, ICK-JOON CHO, HYUNG-JOO YU, BORA HAN, HYUNG-HOON OH, YOON-JIN SEO, KI-HYUN KIM, DAE-SEONG MYUNG, SUNG-BOM CHO, WAN-SIK LEE, TAEK-KEUN NAM, and YOUNG-EUN JOO

Subjects
Cancer Research, Oncology, Risk Factors, Humans, Proctitis, General Medicine, Radiotherapy, Conformal, Retrospective Studies, Pelvis
Abstract

Pelvic radiation therapy (RT) is a common treatment for malignancies, including gynecological, genitourinary, and lower gastrointestinal tract cancers. However, chronic radiation proctitis (RP) is an unavoidable side effect, and its clinical presentation varies from asymptomatic to potentially life-threatening. This study evaluated the clinical characteristics and risk factors of chronic RP.Patients with chronic RP (212) following RT for various pelvic cancers between January 2015 and December 2021 were enrolled. Clinical characteristics of RP were analyzed retrospectively. Severity was graded according to the Radiation Therapy Oncology Group (RTOG) modified rectal toxicity score and Vienna rectoscopy score (VRS), and risk factors were statistically analyzed.The most common pelvic cancer observed was cervical cancer. The patients received three-dimensional conformal RT (3D-CRT), intensity-modulated RT, or a combination of 3D-CRT and intracavitary RT (ICR). Rectal bleeding occurred in 70 (33.0%) patients. Previous abdominopelvic surgery and total radiation dose significantly correlated with the RTOG score and VRS. Previous abdominopelvic surgery, ICR, and total radiation dose were associated with chronic hemorrhagic RP. All patients with chronic hemorrhagic RP were treated with argon plasma coagulation (APC). 91.4% of cases required 1-3 APC sessions to resolve the bleeding, with a mean of 1.7 sessions.Our results showed that previous abdominopelvic surgery and total radiation dose were significant risk factors related to chronic RP, while total radiation dose was related to chronic hemorrhagic RP. We also showed that APC was effective and safe for chronic hemorrhagic RP.

Published
2022

4. Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer

Author

YOUNG-LAN PARK, SUNG-BUM CHO, SUN-YOUNG PARK, HYUNG-HOON OH, EUN MYUNG, CHAN-MUK IM, SEYEONG SON, SEUNGHEE KIM, SEO-YEON CHO, MIN-WOO CHUNG, JI-YUN HONG, KI-HYUN KIM, DAE-SEONG MYUNG, WAN-SIK LEE, DAEHO PARK, and YOUNG-EUN JOO

Subjects
Cancer Research, Glycogen Synthase Kinase 3 beta, Caspase 3, Cyclin-Dependent Kinase 2, General Medicine, Poly(ADP-ribose) Polymerase Inhibitors, Prognosis, Cadherins, Gene Expression Regulation, Neoplastic, Oncology, Cell Movement, Cell Line, Tumor, Claudin-1, Humans, Vimentin, Myeloid Cell Leukemia Sequence 1 Protein, Cyclin D1, RNA, Small Interfering, Colorectal Neoplasms, Proto-Oncogene Proteins c-akt, Cell Proliferation
Abstract

Engulfment and cell motility 1 (ELMO1) plays a crucial role in the process of migration, chemotaxis, and metastasis of tumor cells. ELMO1 has been implicated in the pathogenesis of various cancers. However, the distinct function of ELMO1 in colorectal cancer (CRC) is unclear. We determined whether ELMO1 affects the oncogenic behavior of CRC cells and investigated its prognostic value in CRC patients.We investigated the impact of ELMO1 on tumor cell behavior using small interference RNA (siRNA) in CRC cell lines, including SW480 and DLD1. The expression of ELMO1 was investigated by reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA) in cancer tissues and sera obtained from CRC patients.ELMO1 knockdown suppressed tumor cell proliferation in SW480 and DLD1 cells. ELMO1 knockdown-induced apoptosis through up-regulation of caspase-3, -7, and PARP activities and down-regulation of the anti-apoptotic Mcl-1 protein. ELMO1 knockdown-induced cell-cycle arrest by decreasing cyclin D1, cyclin-dependent kinase 2, 4 and 6, and the 25C cell division cycle (CDC25C). ELMO1 knockdown suppressed tumor cell invasion and migration. The expression of E-cadherin was increased, while that of Vimentin and Claudin 1 decreased following ELMO1 knockdown. The phosphorylation levels of PDK1, Akt, and GSK-3β and were down-regulated after ELMO1 knockdown. The expression of ELMO1 was found up-regulated in cancer tissues and sera taken from CRC patients. ELMO1 expression was significantly associated with tumor stage, lymph node metastasis, distant metastases, and poor survival.ELMO1 mediates tumor progression by increasing tumor cell motility and inhibiting apoptosis in human CRC.

Published
2022

5. Engulfment and Cell Motility1 Regulate Tumor Cell Behaviors and Predict Prognosis in Colorectal Cancer

Author

Young-Lan Park, Sung-Bum Cho, Sun-Young Park, Hyung-Hoon Oh, Eun Myung, Chan-Muk Im, Seyeong Son, Seunghee Kim, Seo-Yeon Cho, Min-Woo Chung, Ji-Yun Hong, Ki-Hyun Kim, Dae-Seong Myung, Wan-Sik Lee, Daeho Park, and Young-Eun Joo

Abstract

Background: Engulfment and cell motility 1 (ELMO1) plays a crucial role in the process of migration, chemotaxis, and metastasis of tumor cells. ELMO 1 has been implicated in the pathogenesis of various cancers. However, the distinct function of ELMO1 in colorectal cancer (CRC) is unclear. We determined whether ELMO1 affected the oncogenic behavior of CRC cells and investigated its prognostic value in CRC patients. Methods: We investigated the impact of ELMO1 on tumor cell behaviors using small interference RNA in CRC cell lines, including SW480 and DLD1. The expression of ELMO1 was investigated by reverse transcription-polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay in cancer tissues and sera taken from CRC patients. Results: ELMO1 knockdown suppressed tumor cell proliferation in SW480 and DLD1 cells. ELMO1 knockdown-induced apoptosis through up-regulation of caspase-3, -7, and PARP activities and down-regulation of the anti-apoptotic Mcl-1 protein. ELMO1 knockdown-induced cell cycle arrest by decreasing cyclin D1, cyclin-dependent kinase 2, 4 and 6, and the 25C cell division cycle (CDC25C). ELMO1 knockdown suppressed tumor cell invasion and migration. The expression of E-cadherin was increased, and Vimentin and Claudin 1 decreased with ELMO1 knockdown. The phosphorylation levels of PDK1, Akt, and GSK-3β and were down-regulated by ELMO1 knockdown. The expression of ELMO1 was up-regulated in cancer tissues and sera taken from CRC patients. ELMO1 expression was significantly associated with tumor stage, lymph node metastasis, distant metastases, and poor survival. Conclusions: These results indicate that ELMO1 mediates tumor progression by increasing tumor cell motility and inhibiting apoptosis in human CRC.

Published
2022
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6. CD47 mediates the progression of colorectal cancer by inducing tumor cell apoptosis and angiogenesis

Author

Hyung-Hoon, Oh, Young-Lan, Park, Sun-Young, Park, Eun, Myung, Chan-Muk, Im, Hyung-Joo, Yu, Bora, Han, Yoon-Jin, Seo, Ki-Hyun, Kim, Dae-Seong, Myung, Sung-Bum, Cho, Wan-Sik, Lee, Daeho, Park, and Young-Eun, Joo

Subjects
Ki-67 Antigen, Humans, CD47 Antigen, Apoptosis, Cell Biology, Lymphangiogenesis, Colorectal Neoplasms, Pathology and Forensic Medicine
Abstract

CD47 is an immunoregulatory protein that is found on the cell surface and plays significant roles in cellular functions such as proliferation, apoptosis, migration, and immune homeostasis. CD47 is overexpressed in various human cancers and is associated with tumor development, progression, and poor prognosis. In this study, we analyzed the expression of CD47 to determine whether it affected the oncogenic behavior of colorectal cancer (CRC) and investigated the prognostic value of CD47 expression in patients with CRC. We investigated 468 patients with CRC who underwent curative surgery and examined the expression of CD47 in tumor and lymph node tissues by performing RT-PCR and immunohistochemistry. Apoptosis, proliferation, angiogenesis, and lymphangiogenesis were determined via a TUNEL assay and immunohistochemical staining for Ki-67, CD34, and D2-40. CD47 expression was increased in human CRC tumors and metastatic lymph nodes compared with normal colorectal mucosa and non-metastatic lymph node tissues. CD47 expression was significantly associated with perineural invasion, lymphovascular invasion, cell differentiation, cancer stage, depth of invasion, lymph node metastasis, distant metastasis, and poor survival. The mean apoptotic index and microvessel density value of CD47-positive tumors were significantly higher than those of CD47-negative tumors. However, no significant difference was observed between CD47 expression and Ki-67 labeling index or lymphatic vessel density. These results indicate that CD47 mediated the progression of CRC by inducing tumor cell apoptosis and angiogenesis.

Published
2022
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7. Clinical Outcomes of Endoscopic Incompletely Resected Rectal Neuroendocrine Tumors and Risk Factors Associated with Residual Tumors after Salvage Treatment.

Author

Youngeun Seo, Young-eun Joo, Hyung-hoon Oh, Chae-jube Lim, Je-seoung Kim, Chan-muk Im, You, Garam, and Seoungeon Kim

Subjects
ENDOSCOPIC surgery, RECTUM tumors, NEUROENDOCRINE tumors, SURGICAL excision, PROGRESSION-free survival
Abstract

Background/Aims In recent years, a significant increase in incidence of rectal neuroendocrine tumors (NETs) has consequently increased in the importance of their optimal treatment and post-treatment management. Endoscopic resection has become a primary option for the treatment of grade 1 rectal NETs, less than 10 mm, but there is also a higher risk of residual tumors, compared to surgical resection. The study aimed to investigate the clinical outcomes of incompletely resected grade 1 rectal NETs and risk factors associated with prediction of residual tumors after salvage treatment. Methods Patients with grade 1 rectal NETs who underwent incomplete endoscopic resection from 2008 to 2023 were enrolled and their medical records were reviewed retrospectively. Finally, a total of 205 rectal NETs with the pathologic reports of incomplete resection were collected for data analysis. Results Among 205 patients, 76 patients received the salvage treatment and 126patients had been on a regular follow-up schedule without the salvage treatment. The mean follow-up period of enrolled patients was 35.0±37.6 months. The mean follow-up period of the salvage treatment and regular follow-up groups was 33.5±28.3 and 35.9±42.2 months, respectively. Local recurrence, metastasis, and disease-free survival rates did not show significant differences between the salvage treatment and regular follow-up groups. In the salvage treatment group, residual tumors were found in 23 (32.4%) patients. Primary endoscopic resection methods such as cold forceps, cold snare polypectomy, and conventional endoscopic mucosal resection (EMR), and primary endoscopic resection at non-tertiary medical center were the significant risk factors associated with residual tumors after the salvage treatment Conclusion Primary endoscopic resection methods such as cold forceps, cold snare polypectomy, and conventional EMR, and primary endoscopic resection at non-tertiary medical centers were the significant risk factors associated with prediction of the residual tumors after salvage treatment. [ABSTRACT FROM AUTHOR]

Published
2024

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