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41 results on '"CMM Groep Bos"'

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1. Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

2. A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

3. Oxygen-consumption based quantification of chemogenetic H2O2 production in live human cells

4. Functional determination of emicizumab in presence of factor VIII activity

5. A second case of glutaminase hyperactivity: Expanding the phenotype with epilepsy

6. Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

7. Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration

8. Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

9. FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

10. Development of a plain-language guide for discussing breast cancer genetic counseling and testing with patients with limited health literacy

11. mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy

12. NAA80 bi-allelic missense variants result in high-frequency hearing loss, muscle weakness and developmental delay

13. Treatment of ARS deficiencies with specific amino acids

14. Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

15. Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

16. Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants

17. Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

18. Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

19. De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia

20. MDH1 deficiency is a metabolic disorder of the malate–aspartate shuttle associated with early onset severe encephalopathy

21. Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy

22. Discovery of pyridoxal reductase activity as part of human vitamin B6 metabolism

23. GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

24. Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase

26. Zygotic vinculin is not essential for embryonic development in zebrafish

28. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

29. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

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37. Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

38. The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

39. Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

41. The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex

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