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21 results on '"Capello, Daniela"'

5. A eficácia de programas de treinamento de professores online

Author

Lopes, João, primary, Capello, Daniela de Souza, additional, Amorim, Joseane Maria Fianco, additional, Costa, Luciene da, additional, Braga, Neide Rafael Alves, additional, Santos, Sandra Benites dos, additional, Santos, Taciane do Rosario dos, additional, and Fernandes, Wélida Verdam de Souza, additional

Published
2024
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7. Extracellular vesicles from human plasma for biomarkers discovery: Impact of anticoagulants and isolation techniques

Author

Bettio, Valentina, primary, Mazzucco, Eleonora, additional, Antona, Annamaria, additional, Cracas, Silvia, additional, Varalda, Marco, additional, Venetucci, Jacopo, additional, Bruno, Stefania, additional, Chiabotto, Giulia, additional, Venegoni, Chiara, additional, Vasile, Alessandra, additional, Chiocchetti, Annalisa, additional, Quaglia, Marco, additional, Camussi, Giovanni, additional, Cantaluppi, Vincenzo, additional, Panella, Massimiliano, additional, Rolla, Roberta, additional, Manfredi, Marcello, additional, and Capello, Daniela, additional

Published
2023
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8. Supplementary Tables S1-S4 from The Prognostic Value of TP53 Mutations in Chronic Lymphocytic Leukemia Is Independent of Del17p13: Implications for Overall Survival and Chemorefractoriness

Author

Rossi, Davide, primary, Cerri, Michaela, primary, Deambrogi, Clara, primary, Sozzi, Elisa, primary, Cresta, Stefania, primary, Rasi, Silvia, primary, De Paoli, Lorenzo, primary, Spina, Valeria, primary, Gattei, Valter, primary, Capello, Daniela, primary, Forconi, Francesco, primary, Lauria, Francesco, primary, and Gaidano, Gianluca, primary

Published
2023
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9. CCR Translation for this Article from Expression of Mutated IGHV3-23 Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features

Author

Bomben, Riccardo, primary, Dal-Bo, Michele, primary, Benedetti, Dania, primary, Capello, Daniela, primary, Forconi, Francesco, primary, Marconi, Daniela, primary, Bertoni, Francesco, primary, Maffei, Rossana, primary, Laurenti, Luca, primary, Rossi, Davide, primary, Del Principe, Maria Ilaria, primary, Luciano, Fabrizio, primary, Sozzi, Elisa, primary, Cattarossi, Ilaria, primary, Zucchetto, Antonella, primary, Rossi, Francesca Maria, primary, Bulian, Pietro, primary, Zucca, Emanuele, primary, Nicoloso, Milena S., primary, Degan, Massimo, primary, Marasca, Roberto, primary, Efremov, Dimitar G., primary, Del Poeta, Giovanni, primary, Gaidano, Gianluca, primary, and Gattei, Valter, primary

Published
2023
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10. Supplementary Data from Expression of Mutated IGHV3-23 Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features

Author

Bomben, Riccardo, primary, Dal-Bo, Michele, primary, Benedetti, Dania, primary, Capello, Daniela, primary, Forconi, Francesco, primary, Marconi, Daniela, primary, Bertoni, Francesco, primary, Maffei, Rossana, primary, Laurenti, Luca, primary, Rossi, Davide, primary, Del Principe, Maria Ilaria, primary, Luciano, Fabrizio, primary, Sozzi, Elisa, primary, Cattarossi, Ilaria, primary, Zucchetto, Antonella, primary, Rossi, Francesca Maria, primary, Bulian, Pietro, primary, Zucca, Emanuele, primary, Nicoloso, Milena S., primary, Degan, Massimo, primary, Marasca, Roberto, primary, Efremov, Dimitar G., primary, Del Poeta, Giovanni, primary, Gaidano, Gianluca, primary, and Gattei, Valter, primary

Published
2023
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11. Public Attitude towards Biobanking: An Italian University Survey

Author

Aleni, Chiara, primary, Rinaldi, Carmela, additional, Bettio, Valentina, additional, Mazzucco, Eleonora, additional, Antona, Annamaria, additional, Meini, Cristina, additional, Loria, Emiliano, additional, Bonvicini, Paolo, additional, Cracas, Silvia Vittoria, additional, Caristia, Silvia, additional, Rimedio, Antonio, additional, Faggiano, Fabrizio, additional, Ferrante, Daniela, additional, and Capello, Daniela, additional

Published
2022
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12. UPO Biobank: The Challenge of Integrating Biobanking into the Academic Environment to Support Translational Research.

Author

Bettio, Valentina, Mazzucco, Eleonora, Aleni, Chiara, Cracas, Silvia, Rinaldi, Carmela, Antona, Annamaria, Varalda, Marco, Venetucci, Jacopo, Ferrante, Daniela, Rimedio, Antonio, and Capello, Daniela

Subjects
TRANSLATIONAL research, BIOLOGICAL specimens, INDIVIDUALIZED medicine, BIOMATERIALS, LONGITUDINAL method
Abstract

Biobanks are driving motors of precision and personalized medicine by providing high-quality biological material/data through the standardization and harmonization of their collection, preservation, and distribution. UPO Biobank was established in 2020 as an institutional, disease, and population biobank within the University of Piemonte Orientale (UPO) for the promotion and support of high-quality, multidisciplinary studies. UPO Biobank collaborates with UPO researchers, sustaining academic translational research, and supports the Novara Cohort Study, a longitudinal cohort study involving the population in the Novara area that will collect data and biological specimens that will be available for epidemiological, public health, and biological studies on aging. UPO Biobank has been developed by implementing the quality standards for the field and the ethical and legal issues and normative about privacy protection, data collection, and sharing. As a member of the "Biobanking and Biomolecular Resources Research Infrastructure" (BBMRI) network, UPO Biobank aims to expand its activity worldwide and launch cooperation with new national and international partners and researchers. The objective of this manuscript is to report an institutional and operational experience through the description of the technical and procedural solutions and ethical and scientific implications associated with the establishment of this university research biobank. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer

Author

Antona, Annamaria, primary, Varalda, Marco, additional, Roy, Konkonika, additional, Favero, Francesco, additional, Mazzucco, Eleonora, additional, Zuccalà, Miriam, additional, Leo, Giovanni, additional, Soggia, Giulia, additional, Bettio, Valentina, additional, Tosi, Martina, additional, Gaggianesi, Miriam, additional, Riva, Beatrice, additional, Reano, Simone, additional, Genazzani, Armando, additional, Manfredi, Marcello, additional, Stassi, Giorgio, additional, Corà, Davide, additional, D’Alfonso, Sandra, additional, and Capello, Daniela, additional

Published
2022
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14. Persistence of Neutralizing Antibodies to SARS-CoV-2 in First Wave Infected Individuals at Ten Months Post-Infection: The UnIRSA Cohort Study

Author

Griffante, Gloria, primary, Chandel, Shikha, additional, Ferrante, Daniela, additional, Caneparo, Valeria, additional, Capello, Daniela, additional, Bettio, Valentina, additional, Borgogna, Cinzia, additional, Aleni, Chiara, additional, Esposito, Salvatore, additional, Sarro, Andrea, additional, Vasile, Alessandra, additional, Comba, Marco, additional, Testa, Tommaso, additional, Cotrupi, Gianmarco, additional, De Andrea, Marco, additional, Bortoluzzi, Sara, additional, and Gariglio, Marisa, additional

Published
2021
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15. Identification of Key Phospholipids That Bind and Activate Atypical PKCs

Author

Velnati, Suresh, primary, Centonze, Sara, additional, Girivetto, Federico, additional, Capello, Daniela, additional, Biondi, Ricardo M., additional, Bertoni, Alessandra, additional, Cantello, Roberto, additional, Ragnoli, Beatrice, additional, Malerba, Mario, additional, Graziani, Andrea, additional, and Baldanzi, Gianluca, additional

Published
2021
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17. Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors

Author

Velnati, Suresh, primary, Massarotti, Alberto, additional, Antona, Annamaria, additional, Talmon, Maria, additional, Fresu, Luigia Grazia, additional, Galetto, Alessandra Silvia, additional, Capello, Daniela, additional, Bertoni, Alessandra, additional, Mercalli, Valentina, additional, Graziani, Andrea, additional, Tron, Gian Cesare, additional, and Baldanzi, Gianluca, additional

Published
2019
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18. Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors.

Author

Velnati, Suresh, Massarotti, Alberto, Antona, Annamaria, Talmon, Maria, Fresu, Luigia Grazia, Galetto, Alessandra Silvia, Capello, Daniela, Bertoni, Alessandra, Mercalli, Valentina, Graziani, Andrea, Tron, Gian Cesare, and Baldanzi, Gianluca

Subjects
STRUCTURE-activity relationships, SEROTONIN antagonists, SEROTONIN receptors, CELL migration, MOLECULAR models
Abstract

A series of analogues of Amb639752, a novel diacylglycerol kinase (DGK) inhibitor recently discovered by us via virtual screening, have been tested. The compounds were evaluated as DGK inhibitors on α, θ, and ζ isoforms, and as antagonists on serotonin receptors. From these assays emerged two novel compounds, namely 11 and 20, which with an IC50 respectively of 1.6 and 1.8 µM are the most potent inhibitors of DGKα discovered to date. Both compounds demonstrated the ability to restore apoptosis in a cellular model of X-linked lymphoproliferative disease as well as the capacity to reduce the migration of cancer cells, suggesting their potential utility in preventing metastasis. Finally, relying on experimental biological data, molecular modelling studies allow us to set a three-point pharmacophore model for DGK inhibitors. [ABSTRACT FROM AUTHOR]

Published
2020
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19. Cover Image, Volume 232, Number 9, September 2017

Author

Poli, Alessandro, primary, Fiume, Roberta, additional, Baldanzi, Gianluca, additional, Capello, Daniela, additional, Ratti, Stefano, additional, Gesi, Marco, additional, Manzoli, Lucia, additional, Graziani, Andrea, additional, Suh, Pann-Ghill, additional, Cocco, Lucio, additional, and Follo, Matilde Y., additional

Published
2017
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21. Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression

Author

Poli, A, Fiume, R, Baldanzi, G, Capello, D, Ratti, S, Gesi, Marco, Manzoli, L, Graziani, A, Suh, Pg, Cocco, L, Follo, M. Y., Poli, Alessandro, Fiume, Roberta, Baldanzi, Gianluca, Capello, Daniela, Ratti, Stefano, Gesi, Marco, Manzoli, Lucia, Graziani, Andrea, Suh, Pann Ghill, Cocco, Lucio, Follo, Matilde Y., and Suh, Pann-Ghill

Subjects
Diacylglycerol Kinase, Time Factors, Cell Cycle, K562 Cells, Nucleus, Phosphatidylinositol, Physiology, Clinical Biochemistry, Erythroblastic, Cell Nucleus, Dose-Response Relationship, Drug, Humans, Isoenzymes, Leukemia, Erythroblastic, Acute, Phosphorylation, Protein Kinase Inhibitors, RNA Interference, Retinoblastoma Protein, Signal Transduction, Transfection, Cell Proliferation, G1 Phase Cell Cycle Checkpoints, Cell Biology, Acute, Dose-Response Relationship, Leukemia, Medicine (all), Nucleus, Dyacylglycerol, Cell Cycle, Erythroleukemia, K562, Drug
Abstract

Phosphatidylinositol (PI) signaling is an essential regulator of cell motility and proliferation. A portion of PI metabolism and signaling takes place in the nuclear compartment of eukaryotic cells, where an array of kinases and phosphatases localize and modulate PI. Among these, Diacylglycerol Kinases (DGKs) are a class of phosphotransferases that phosphorylate diacylglycerol and induce the synthesis of phosphatidic acid. Nuclear DGKalpha modulates cell cycle progression, and its activity or expression can lead to changes in the phosphorylated status of the Retinoblastoma protein, thus, impairing G1/S transition and, subsequently, inducing cell cycle arrest, which is often uncoupled with apoptosis or autophagy induction. Here we report for the first time not only that the DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, but also that its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression. J. Cell. Physiol. 232: 2550-2557, 2017. © 2016 Wiley Periodicals, Inc.

Published
2017

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