1. Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans
- Author
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Kirsi A. Virtanen, Maren R. Laughlin, Frank I. Lin, Miriam A. Bredella, Paul E. Kinahan, Kong Y. Chen, Houchun H. Hu, Carol Renfrew Haft, John Sunderland, Aaron M. Cypess, Sven Enerbäck, Wouter D. van Marken Lichtenbelt, Richard L. Wahl, RS: NUTRIM - HB/BW section B, RS: NUTRIM - R1 - Metabolic Syndrome, and Humane Biologie
- Subjects
0301 basic medicine ,Physiology ,Statistics as Topic ,Cold exposure ,Adipose tissue ,030209 endocrinology & metabolism ,Computed tomography ,Guidelines as Topic ,Article ,03 medical and health sciences ,0302 clinical medicine ,Adipose Tissue, Brown ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Brown adipose tissue ,medicine ,Humans ,Molecular Biology ,Fluorodeoxyglucose ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Cell Biology ,Organ Size ,030104 developmental biology ,medicine.anatomical_structure ,Positron emission tomography ,Fdg pet ct ,Metabolic activity ,Nuclear medicine ,business ,medicine.drug - Abstract
Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked.
- Published
- 2016