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Your search keyword '"Castillo-Martin, Mireia"' showing total 282 results
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282 results on '"Castillo-Martin, Mireia"'

1. Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients with colorectal cancer

Author

Costa, Bruna, primary, Estrada, Marta F., additional, Gomes, António, additional, Fernandez, Laura M., additional, Azevedo, José M., additional, Póvoa, Vanda, additional, Fontes, Márcia, additional, Alves, António, additional, Galzerano, António, additional, Castillo-Martin, Mireia, additional, Herrando, Ignacio, additional, Brandão, Shermann, additional, Carneiro, Carla, additional, Nunes, Vítor, additional, Carvalho, Carlos, additional, Parvaiz, Amjad, additional, Marreiros, Ana, additional, and Fior, Rita, additional

Published
2024
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2. PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Author

Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Fernandez-Ruiz, Sonia, Viera, Cristina, Carlevaris, Onintza, Ercilla, Amaia, Mendizabal, Isabel, Martin, Teresa, Macchia, Alice, Camacho, Laura, Pujana-Vaquerizo, Mikel, Sanchez-Mosquera, Pilar, Torrano, Verónica, Martin-Martin, Natalia, Zuniga-Garcia, Patricia, Castillo-Martin, Mireia, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Unda, Miguel, Mato, Jose M., Berra, Edurne, Martinez-Chantar, Maria L., and Carracedo, Arkaitz

Published
2022
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4. Characterization and detection of colorectal cancer by multidimensional autofluorescence lifetime imaging: a preliminary study on surgical specimens

Author

Herrando, Alberto Ignacio, primary, Castillo Martin, Mireia, additional, Galzerano, Antonio, additional, Fernández, Laura M., additional, Vieira, Pedro, additional, Azevedo, José, additional, Parvaiz, Amjad, additional, Shcheslavskiy, Vladislav, additional, Cicchi, Riccardo, additional, García Silva, Pedro, additional, and Lagarto, João L., additional

Published
2024
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8. Dual excitation spectral autofluorescence lifetime and reflectance imaging for fast macroscopic characterization of tissues

Author

Herrando, Alberto, primary, Castillo-Martin, Mireia, additional, Galzerano, Antonio, additional, Fernández, Laura, additional, Vieira, Pedro, additional, Azevedo, José, additional, Parvaiz, Amjad, additional, Cicchi, Riccardo, additional, Shcheslavskiy, Vladislav, additional, Silva, Pedro, additional, and Lagarto, Joao, additional

Published
2023
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13. Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis

Author

Chen, Ming, Zhang, Jiangwen, Berger, Alice H., Diolombi, Moussa S., Ng, Christopher, Fung, Jacqueline, Bronson, Roderick T., Castillo-Martin, Mireia, Thin, Tin Htwe, Cordon-Cardo, Carlos, Plevin, Robin, and Pandolfi, Pier Paolo

Subjects
Carcinogenesis -- Research, Cellular signal transduction -- Research, Lung -- Health aspects, Health care industry
Abstract

Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting the mouse orthologs of human DOK2 and DUSP4 genes, which were co-deleted in approximately half of human lung adenocarcinomas, we found that compound-heterozygous deletion of Dok2 and Dusp4 in mice resulted in lung tumorigenesis with short latency and high incidence, and that their co-deletion synergistically activated MAPK signaling and promoted cell proliferation. Conversely, restoration of DOK2 and DUSP4 in lung cancer cells suppressed MAPK activation and cell proliferation. Importantly, in contrast to downregulation of DOK2 or DUSP4 alone, concomitant downregulation of DOK2 and DUSP4 was associated with poor survival in human lung adenocarcinoma. Therefore, our findings lend in vivo experimental support to the notion that compound haploinsufficiency, due to broad-scale chromosome deletions, constitutes a driving force in tumorigenesis., IntroductionHuman cancers are characterized by recurrent somatic copy number alterations (SCNAs), which include both focal and broad arm-level amplifications and deletions (1). How these alterations contribute to tumorigenesis remains a [...]

Published
2019
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14. Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Author

Guarnerio, Jlenia, Zhang, Yang, Cheloni, Giulia, Panella, Riccardo, Mae Katon, Jesse, Simpson, Mark, Matsumoto, Akinobu, Papa, Antonella, Loretelli, Cristian, Petri, Andreas, Kauppinen, Sakari, Garbutt, Cassandra, Nielsen, Gunnlaugur Petur, Deshpande, Vikram, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Dimitrios, Spentzos, Clohessy, John G., Batish, Mona, and Pandolfi, Pier Paolo

Published
2019
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16. International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy.

Author

El Sissy, Carine, Kirilovsky, Amos, Lagorce Pagès, Christine, Marliot, Florence, Custers, Petra A., Dizdarevic, Edina, Sroussi, Marine, Castillo-Martin, Mireia, Haicheur, Nacilla, Dermani, Mohamed, Loche, Nicolas, Buttard, Bénedicte, Musina, Ana Maria, Anitei, Maria Gabriela, van den Berg, José G., Broeks, Annegien, Iseas, Soledad, Coraglio, Mariana, Loria, Fernando Sanchez, and Romero, Alfredo

Published
2024
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20. An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

Author

Chen, Ming, Zhang, Jiangwen, Sampieri, Katia, Clohessy, John G., Mendez, Lourdes, Gonzalez-Billalabeitia, Enrique, Liu, Xue-Song, Lee, Yu-Ru, Fung, Jacqueline, Katon, Jesse M., Menon, Archita Venugopal, Webster, Kaitlyn A., Ng, Christopher, Palumbieri, Maria Dilia, Diolombi, Moussa S., Breitkopf, Susanne B., Teruya-Feldstein, Julie, Signoretti, Sabina, Bronson, Roderick T., Asara, John M., Castillo-Martin, Mireia, Cordon-Cardo, Carlos, and Pandolfi, Pier Paolo

Published
2018
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22. Supplementary Figure S6. Ar expression in primary and metastatic tumors. from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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24. Supplementary Figure S2. Genetic tools used for dissecting Il6/Stat3/Myc signaling. from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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25. Supplementary Figure Legend from Preclinical Analysis of the γ-Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

Author

Samon, Jeremy B., primary, Castillo-Martin, Mireia, primary, Hadler, Michael, primary, Ambesi-Impiobato, Alberto, primary, Paietta, Elisabeth, primary, Racevskis, Janis, primary, Wiernik, Peter H., primary, Rowe, Jacob M., primary, Jakubczak, John, primary, Randolph, Sophia, primary, Cordon-Cardo, Carlos, primary, and Ferrando, Adolfo A., primary

Published
2023
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26. Data from Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis

Author

Lunardi, Andrea, primary, Varmeh, Shohreh, primary, Chen, Ming, primary, Taulli, Riccardo, primary, Guarnerio, Jlenia, primary, Ala, Ugo, primary, Seitzer, Nina, primary, Ishikawa, Tomoki, primary, Carver, Brett S., primary, Hobbs, Robin M., primary, Quarantotti, Valentina, primary, Ng, Christopher, primary, Berger, Alice H., primary, Nardella, Caterina, primary, Poliseno, Laura, primary, Montironi, Rodolfo, primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Signoretti, Sabina, primary, and Pandolfi, Pier Paolo, primary

Published
2023
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27. Supplementary Figure Legends from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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29. Data from Preclinical Analysis of the γ-Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

Author

Samon, Jeremy B., primary, Castillo-Martin, Mireia, primary, Hadler, Michael, primary, Ambesi-Impiobato, Alberto, primary, Paietta, Elisabeth, primary, Racevskis, Janis, primary, Wiernik, Peter H., primary, Rowe, Jacob M., primary, Jakubczak, John, primary, Randolph, Sophia, primary, Cordon-Cardo, Carlos, primary, and Ferrando, Adolfo A., primary

Published
2023
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31. Supplementary Figure S1. Copy Number Alteration analysis of human prostate cancer confirms loss of PTEN and TP53 genes as a genetic hallmark of metastatic prostate cancer. from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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33. Supplementary Figure S3. Tools used for targeting of Il6 and Stat3. from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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35. Supplementary Figure 1 from Preclinical Analysis of the γ-Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

Author

Samon, Jeremy B., primary, Castillo-Martin, Mireia, primary, Hadler, Michael, primary, Ambesi-Impiobato, Alberto, primary, Paietta, Elisabeth, primary, Racevskis, Janis, primary, Wiernik, Peter H., primary, Rowe, Jacob M., primary, Jakubczak, John, primary, Randolph, Sophia, primary, Cordon-Cardo, Carlos, primary, and Ferrando, Adolfo A., primary

Published
2023
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36. Supplementary Figure S5. IHC analysis of wild type lung and primary and metastatic tumors. from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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37. Supplementary Figure S3 from Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis

Author

Lunardi, Andrea, primary, Varmeh, Shohreh, primary, Chen, Ming, primary, Taulli, Riccardo, primary, Guarnerio, Jlenia, primary, Ala, Ugo, primary, Seitzer, Nina, primary, Ishikawa, Tomoki, primary, Carver, Brett S., primary, Hobbs, Robin M., primary, Quarantotti, Valentina, primary, Ng, Christopher, primary, Berger, Alice H., primary, Nardella, Caterina, primary, Poliseno, Laura, primary, Montironi, Rodolfo, primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Signoretti, Sabina, primary, and Pandolfi, Pier Paolo, primary

Published
2023
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38. Supplementary Figure Legends from Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis

Author

Lunardi, Andrea, primary, Varmeh, Shohreh, primary, Chen, Ming, primary, Taulli, Riccardo, primary, Guarnerio, Jlenia, primary, Ala, Ugo, primary, Seitzer, Nina, primary, Ishikawa, Tomoki, primary, Carver, Brett S., primary, Hobbs, Robin M., primary, Quarantotti, Valentina, primary, Ng, Christopher, primary, Berger, Alice H., primary, Nardella, Caterina, primary, Poliseno, Laura, primary, Montironi, Rodolfo, primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Signoretti, Sabina, primary, and Pandolfi, Pier Paolo, primary

Published
2023
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39. Supplementary Figure S4. Activation of Stat3/Myc signaling is specific to Ptenpc-/-; Trp53pc-/-prostate and leads to stromal expansion. from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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40. Supplementary Figure S7. Pathway to Pten/ Trp53 deficient prostate metastasis and therapy resistance. from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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41. Supplementary Figure Legends from A Genetic Platform to Model Sarcomagenesis from Primary Adult Mesenchymal Stem Cells

Author

Guarnerio, Jlenia, primary, Riccardi, Luisa, primary, Taulli, Riccardo, primary, Maeda, Takahiro, primary, Wang, Guocan, primary, Hobbs, Robin M., primary, Song, Min Sup, primary, Sportoletti, Paolo, primary, Bernardi, Rosa, primary, Bronson, Roderick T., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Lunardi, Andrea, primary, and Pandolfi, Pier Paolo, primary

Published
2023
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43. Supplementary Figures S1 - S5 from A Genetic Platform to Model Sarcomagenesis from Primary Adult Mesenchymal Stem Cells

Author

Guarnerio, Jlenia, primary, Riccardi, Luisa, primary, Taulli, Riccardo, primary, Maeda, Takahiro, primary, Wang, Guocan, primary, Hobbs, Robin M., primary, Song, Min Sup, primary, Sportoletti, Paolo, primary, Bernardi, Rosa, primary, Bronson, Roderick T., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Lunardi, Andrea, primary, and Pandolfi, Pier Paolo, primary

Published
2023
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45. Supplementary Figure 3 from Preclinical Analysis of the γ-Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

Author

Samon, Jeremy B., primary, Castillo-Martin, Mireia, primary, Hadler, Michael, primary, Ambesi-Impiobato, Alberto, primary, Paietta, Elisabeth, primary, Racevskis, Janis, primary, Wiernik, Peter H., primary, Rowe, Jacob M., primary, Jakubczak, John, primary, Randolph, Sophia, primary, Cordon-Cardo, Carlos, primary, and Ferrando, Adolfo A., primary

Published
2023
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46. Supplementary Figure 2 from Preclinical Analysis of the γ-Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

Author

Samon, Jeremy B., primary, Castillo-Martin, Mireia, primary, Hadler, Michael, primary, Ambesi-Impiobato, Alberto, primary, Paietta, Elisabeth, primary, Racevskis, Janis, primary, Wiernik, Peter H., primary, Rowe, Jacob M., primary, Jakubczak, John, primary, Randolph, Sophia, primary, Cordon-Cardo, Carlos, primary, and Ferrando, Adolfo A., primary

Published
2023
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49. Data from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2

Author

Nowak, Dawid G., primary, Cho, Hyejin, primary, Herzka, Tali, primary, Watrud, Kaitlin, primary, DeMarco, Daniel V., primary, Wang, Victoria M.Y., primary, Senturk, Serif, primary, Fellmann, Christof, primary, Ding, David, primary, Beinortas, Tumas, primary, Kleinman, David, primary, Chen, Muhan, primary, Sordella, Raffaella, primary, Wilkinson, John E., primary, Castillo-Martin, Mireia, primary, Cordon-Cardo, Carlos, primary, Robinson, Brian D., primary, and Trotman, Lloyd C., primary

Published
2023
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50. Data from PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth

Author

Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, primary, Fernández-Ruiz, Sonia, primary, Arreal, Leire, primary, Camacho, Laura, primary, Castillo-Martin, Mireia, primary, Cortazar, Ana R., primary, Torrano, Verónica, primary, Astobiza, Ianire, primary, Zúñiga-García, Patricia, primary, Ugalde-Olano, Aitziber, primary, Loizaga-Iriarte, Ana, primary, Unda, Miguel, primary, Valcárcel-Jiménez, Lorea, primary, Arruabarrena-Aristorena, Amaia, primary, Piva, Marco, primary, Sánchez-Mosquera, Pilar, primary, Aransay, Ana M., primary, Gomez-Muñoz, Antonio, primary, Barrio, Rosa, primary, Sutherland, James D., primary, and Carracedo, Arkaitz, primary

Published
2023
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