8 results on '"Cathryn Gordon Green"'
Search Results
2. Negative emotionality as a candidate mediating mechanism linking prenatal maternal mood problems and offspring internalizing behaviour
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Cathryn Gordon Green, Eszter Szekely, Vanessa Babineau, Alexia Jolicoeur-Martineau, Andrée-Anne Bouvette-Turcot, Klaus Minde, Roberto Sassi, Leslie Atkinson, James L. Kennedy, Meir Steiner, John Lydon, Helene Gaudreau, Jacob A. Burack, Catherine Herba, Marie-Helene Pennestri, Robert Levitan, Michael J. Meaney, and Ashley Wazana
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Psychiatry and Mental health ,education ,Developmental and Educational Psychology - Abstract
Negative emotionality (NE) was evaluated as a candidate mechanism linking prenatal maternal affective symptoms and offspring internalizing problems during the preschool/early school age period. The participants were 335 mother–infant dyads from the Maternal Adversity, Vulnerability and Neurodevelopment project. A Confirmatory Bifactor Analysis (CFA) based on self-report measures of prenatal depression and pregnancy-specific anxiety generated a general factor representing overlapping symptoms of prenatal maternal psychopathology and four distinct symptom factors representing pregnancy-specific anxiety, negative affect, anhedonia and somatization. NE was rated by the mother at 18 and 36 months. CFA based on measures of father, mother, child-rated measures and a semistructured interview generated a general internalizing factor representing overlapping symptoms of child internalizing psychopathology accounting for the unique contribution of each informant. Path analyses revealed significant relationships among the general maternal affective psychopathology, the pregnancy- specific anxiety, and the child internalizing factors. Child NE mediated only the relationship between pregnancy-specific anxiety and the child internalizing factors. We highlighted the conditions in which prenatal maternal affective symptoms predicts child internalizing problems emerging early in development, including consideration of different mechanistic pathways for different maternal prenatal symptom presentations and child temperament.
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- 2022
3. Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months
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Michael J. Meaney, John E. Lydon, Andrée-Anne Bouvette-Turcot, Ashley Wazana, Jacob A. Burack, Leslie Atkinson, Vanessa Babineau, James L. Kennedy, Alexia Jolicoeur-Martineau, Meir Steiner, Martin St-André, Hélène Gaudreau, Klaus Minde, Roberto B. Sassi, Normand Carrey, Robert Levitan, and Cathryn Gordon Green
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medicine.medical_specialty ,Pregnancy ,biology ,05 social sciences ,medicine.disease ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Endocrinology ,Polymorphism (computer science) ,Internal medicine ,5-HTTLPR ,Genotype ,Developmental and Educational Psychology ,biology.protein ,medicine ,Dopamine receptor D4 ,0501 psychology and cognitive sciences ,Allele ,Psychology ,030217 neurology & neurosurgery ,Serotonin transporter ,Depression (differential diagnoses) ,050104 developmental & child psychology ,Clinical psychology - Abstract
Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother–infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from the serotonin transporter linked polymorphic region gene (5-HTTLPR): no long-rs25531(A) (LA: short/short, short/long-rs25531(G) [LG], or LG/LG] vs. any LA) and the dopamine receptor D4 gene (six to eight repeats vs. two to five repeats). Negative emotionality was extracted from the Infant Behaviour Questionnaire—Revised at 3 and 6 months and the Early Child Behavior Questionnaire at 18 and 36 months. Mixed and confirmatory regression analyses indicated that prenatal depression and the multilocus genetic profile interacted to predict negative emotionality from 3 to 36 months. The results were characterized by a differential susceptibility model at 3 and 6 months and by a diathesis–stress model at 36 months.
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- 2016
4. The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age
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Marla B. Sokolowski, Martin St.-André, Cathryn Gordon-Green, John E. Lydon, Alexis Jolicoeur-Martineau, Ashley Wazana, Stephen G. Matthews, Meir Steiner, Hélène Gaudreau, Alison S. Fleming, Robert Levitan, Katherine Pascuzzo, Ellen Moss, Normand Carrey, Gal Tsabari, Justin Graffi, Viara Mileva, Michael J. Meaney, Klaus Minde, Vanessa Lecompte, Vanessa Babineau, André Anne Bouvette-Turcot, Leslie Atkinson, James L. Kennedy, and Roberto B. Sassi
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Male ,Genotype ,Birth weight ,Dysfunctional family ,Article ,Reactive attachment disorder ,Developmental psychology ,Risk Factors ,Developmental and Educational Psychology ,medicine ,Dopamine receptor D4 ,Birth Weight ,Humans ,Genetic Predisposition to Disease ,Risk factor ,Maternal Behavior ,Alleles ,Reactive Attachment Disorder ,Polymorphism, Genetic ,biology ,Socioemotional selectivity theory ,Receptors, Dopamine D4 ,Infant, Newborn ,Infant ,medicine.disease ,Moderation ,Mother-Child Relations ,Psychiatry and Mental health ,Child, Preschool ,biology.protein ,Strange situation ,Female ,Gene-Environment Interaction ,Psychology ,Follow-Up Studies - Abstract
Disorganized attachment is an important early risk factor for socioemotional problems throughout childhood and into adulthood. Prevailing models of the etiology of disorganized attachment emphasize the role of highly dysfunctional parenting, to the exclusion of complex models examining the interplay of child and parental factors. Decades of research have established that extreme child birth weight may have long-term effects on developmental processes. These effects are typically negative, but this is not always the case. Recent studies have also identified the dopamine D4 receptor (DRD4) as a moderator of childrearing effects on the development of disorganized attachment. However, there are inconsistent findings concerning which variant of the polymorphism (seven-repeat long-form allele or non–seven-repeat short-form allele) is most likely to interact with caregiving in predicting disorganized versus organized attachment. In this study, we examined possible two- and three-way interactions and child DRD4 polymorphisms and birth weight and maternal caregiving at age 6 months in longitudinally predicting attachment disorganization at 36 months. Our sample is from the Maternal Adversity, Vulnerability and Neurodevelopment project, a sample of 650 mother–child dyads. Birth weight was cross-referenced with normative data to calculate birth weight percentile. Infant DRD4 was obtained with buccal swabs and categorized according to the presence of the putative allele seven repeat. Macroanalytic and microanalytic measures of maternal behavior were extracted from a videotaped session of 20 min of nonfeeding interaction followed by a 10-min divided attention maternal task at 6 months. Attachment was assessed at 36 months using the Strange Situation procedure, and categorized into disorganized attachment and others. The results indicated that a main effect for DRD4 and a two-way interaction of birth weight and 6-month maternal attention (frequency of maternal looking away behavior) and sensitivity predicted disorganized attachment in robust logistic regression models adjusted for social demographic covariates. Specifically, children in the midrange of birth weight were more likely to develop a disorganized attachment when exposed to less attentive maternal care. However, the association reversed with extreme birth weight (low and high). The DRD4 seven-repeat allele was associated with less disorganized attachment (protective), while non–seven-repeat children were more likely to be classified as disorganized attachment. The implications for understanding inconsistencies in the literature about which DRD4 genotype is the risk direction are also considered. Suggestions for intervention with families with infants at different levels of biological risk and caregiving risk are also discussed.
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- 2015
5. The dopamine D4 receptor gene, birth weight, maternal depression, maternal attention, and the prediction of disorganized attachment at 36 months of age: A prospective gene×environment analysis
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Vanessa Babineau, Klaus Minde, Roberto B. Sassi, Ashley Wazana, Cathryn Gordon-Green, Ellen Moss, Vanessa Lecompte, Viara R. Mileva-Seitz, Meir Steiner, Michael J. Meaney, Justin Graffi, James L. Kennedy, Alexia Jolicoeur-Martineau, Gal Moss, Katherine Pascuzzo, Hélène Gaudreau, Robert Levitan, and Mavan
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Adult ,Male ,Adolescent ,Genotype ,Birth weight ,Developmental psychology ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Dopamine ,Predictive Value of Tests ,Pregnancy ,Developmental and Educational Psychology ,medicine ,Birth Weight ,Humans ,0501 psychology and cognitive sciences ,Attention ,Longitudinal Studies ,Prospective Studies ,Allele ,Maternal Behavior ,Depression (differential diagnoses) ,Depression ,05 social sciences ,Receptors, Dopamine D4 ,Center for Epidemiologic Studies Depression Scale ,Maternal depression ,Object Attachment ,Mother-Child Relations ,Child, Preschool ,Strange situation ,Female ,Gene-Environment Interaction ,Psychology ,030217 neurology & neurosurgery ,050104 developmental & child psychology ,Psychopathology ,medicine.drug ,Clinical psychology ,Follow-Up Studies - Abstract
Background Efforts to understand the developmental pathways for disorganized attachment reflect the importance of disorganized attachment on the prediction of future psychopathology. The inconsistent findings on the prediction of disorganized attachment from the dopamine D4 receptor (DRD4) gene, birth weight, and maternal depression as well as the evidence supporting the contribution of early maternal care, suggest the importance of exploring a gene by environment model. Methods Our sample is from the Maternal Adversity, Vulnerability, and Neurodevelopment project; consisting of 655 mother–child dyads. Birth weight was cross-referenced with normative data to calculate birth weight percentile. Infant DRD4 genotype was obtained with buccal swabs and categorized according to the presence of the 7-repeat allele. Maternal depression was assessed with the Center for Epidemiologic Studies Depression Scale at the prenatal, 6-, 12-, and 24-month assessments. Maternal attention was measured at 6-months using a videotaped session of a 20-min non-feeding interaction. Attachment was assessed at 36-months using the Strange Situation Procedure. Results The presence of the DRD4 7-repeat allele was associated with less disorganized attachment, β = −1.11, OR = 0.33, p = 0.0008. Maternal looking away frequency showed significant interactions with maternal depression at the prenatal assessment, β = 0.003, OR = 1.003, p = 0.023, and at 24 months, β = 0.004, OR = 1.004, p = 0.021, as at both time points, women suffering from depression and with frequent looking away behavior had an increased probability of disorganized attachment in their child, while those with less looking away behavior had a decreased probability of disorganized attachment in their child at 36 months. Conclusions Our models support the contribution of biological and multiple environmental factors in the complex prediction of disorganized attachment at 36 months.
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- 2017
6. Developments in the Developmental Approach to Intellectual Disability
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Cathryn Gordon Green, Jacob A. Burack, Oriane Landry, Grace Iarocci, and Natalie Russo
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Down syndrome ,education.field_of_study ,05 social sciences ,Population ,medicine.disease ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Developmental stage theories ,Intellectual disability ,Learning disability ,medicine ,0501 psychology and cognitive sciences ,Social competence ,Medical model of disability ,medicine.symptom ,Psychology ,education ,030217 neurology & neurosurgery ,050104 developmental & child psychology ,Mental age - Abstract
Based in classic developmental theory and in more than two centuries of ever increasingly sophisticated medical thinking and science, the developmental approach has transformed the theory, methodology, and interpretation of the study of persons with intellectual disability. The primary contributions include the differentiation among persons with intellectual disability by etiology, the application of developmental principles to the specific etiological groups, the emphasis on mental age (MA) (rather than chronological age; CA), and the consideration of the “whole person” along with his or her family and community. In debunking the monolithic approach to intellectual disability as a single disorder, the developmental approach allows for considerably more precision in the study of this population and the resultant rejection of common myths, albeit as part of a process that highlights the extent to which this field is a nascent one. In highlighting the broadening of the understanding of persons with intellectual disability, we review contributions from the study of social competence, language development, and family relations. We then introduce the potential impact and current limitations of the application of cutting-edge technology in the study of neuroscience among persons with intellectual disability. Keywords: developmental approach; etiological differentiation; Down syndrome; fragile X; intellectual disability; mental age (MA); Prader-Willi syndrome; Williams syndrome
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- 2016
7. 2.47 THE DOPAMINE D4 RECEPTOR GENE, BIRTH WEIGHT, EARLY MATERNAL CARE, MATERNAL DEPRESSION OVER THE POSTNATAL TIME PERIOD, AND THE PREDICTION OF DISORGANIZED ATTACHMENT AT 36-MONTHS OF AGE: A PROSPECTIVE GENE X ENVIRONMENT ANALYSIS
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Gal Moss, Justin Graffi, Helen Gaudreau, James L. Kennedy, Roberto Levitan, Vanessa Lecompte, Cathryn Gordon-Green, Normand Carrey, Ashley Wazana, Klaus Minde, Michael J. Meaney, Viara R. Mileva-Seitz, Vanessa Babineau, Meir Steiner, Katherine Pascuzzo, Ellen Moss, Roberto B. Sassi, and Alexis Jolicoeur-Martineau
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050103 clinical psychology ,medicine.medical_specialty ,Pediatrics ,Obstetrics ,Period (gene) ,Environment analysis ,Birth weight ,05 social sciences ,Maternal depression ,Psychiatry and Mental health ,Dopamine ,Developmental and Educational Psychology ,medicine ,0501 psychology and cognitive sciences ,Psychology ,Receptor ,Gene ,050104 developmental & child psychology ,medicine.drug - Published
- 2016
8. 752. A Developmental Model of Atypical Depression Based on Dopamine and Serotonin System Gene Interaction with Pre- And Post-Natal Adversity
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Michael J. Meaney, Hélène Gaudreau, Barbara Wendland, James L. Kennedy, Ashley Wazana, Laurette Dubé, Cathryn Gordon-Green, Meir Steiner, Patrícia Pelufo Silveira, and Robert D. Levitan
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Gene interaction ,Dopamine ,business.industry ,medicine ,Serotonin ,medicine.disease ,business ,Atypical depression ,Pre and post ,Biological Psychiatry ,medicine.drug ,Clinical psychology - Published
- 2017
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