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4. Burden and risk factors of chronic obstructive pulmonary disease in Sub-Saharan African countries, 1990–2019: a systematic analysis for the Global Burden of disease study 2019

Author

Alemayohu, Mulubirhan Assefa, Zanolin, Maria Eisabetta, Cazzoletti, Lucia, Nyasulu, Peter S., Garcia-Larsen, Vanessa, Abtew, Yonas Derso, Adane, Denberu Eshetie, Adesina, Miracle Ayomikun, Barrow, Amadou, Berhie, Alemshet Yirga, Abule Bodicha, Belay Boda, Chanie, Gashaw Sisay, Demeke, Feleke Mekonnen, Dereje, Diriba, Digesa, Lankamo Ena, Ekholuenetale, Michael, Enyew, Daniel Berhanie, Esayas, Hawi Leul, Fagbamigbe, Adeniyi Francis, Fetensa, Getahun, Gebrekidan, Kahsu Gebrekirstos, Gela, Yibeltal Yismaw, Guadie, Habtamu Alganeh, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Kanko, Tesfaye K., Katoto, Patrick D.M.C., Legesse, Samson Mideksa, Mohammed, Shafiu, Nansseu, Jobert Richie, Nzoputam, Ogochukwu Janet, Nzoputam, Chimezie Igwegbe, Odukoya, Oluwakemi Ololade, Okonji, Osaretin Christabel, Owolabi, Mayowa O., Shashamo, Bereket Beyene, Solomon, Yonatan, Temesgen, Worku Animaw, Wubetie, Gedif Ashebir, Yismaw, Yazachew, Zenebe, Getachew Assefa, Zanolin, Maria Elisabetta, and Nyasulu, Peter

Published
2023
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7. Bone Mineral Density in Mountain, Road Cyclists and Untrained Controls: Exercise, Diet and Hormones.

Author

Zamboni, Francesco, Ferrari, Pietro, Cazzoletti, Lucia, Setti, Angela, Bertoldo, Francesco, Dalle Carbonare, Luca G., Danese, Elisa, Tardivo, Stefano, Crisafulli, Ernesto, and Ferrari, Marcello

Subjects
BONE density, CYCLISTS, FEMUR neck, ADIPOSE tissues, LUMBAR vertebrae
Abstract

Purpose: The aim of the study was to compare bone mineral density (BMD) in the lumbar spine (LSBMD) and the femoral neck (FBMD) in male road cyclists (RC n = 39), mountain cyclists (MC n = 30) and controls (C n = 27) and to determine the factors associated with BMD in the same group of participants. Methods: BMD, fat mass (FM) and fat-free mass (FFM) were measured using DXA. Calcium intake (Cal), exercise energy expenditure (EEE) and energy availability (EA) were assessed using self-reported questionnaires. Samples for circulating hormones were also obtained. VO2max was estimated by a cycloergometric test. Results: After adjustment for body mass, in cyclists LSBMD (RC 0.98 ± 0.12; MC 0.98 ± 0.10 g/cm2) was significantly lower than in C (1.11 ± 0.10; p <.001), while FBMD resulted in no significant difference in cyclists compared to C (p = 0.213). EA (kcal/FFM/day) was different in cyclists and in C (p <.05). In C, EEE and EA were positively associated with LSBMD (R = 0.561, R = 0.656, respectively, p <.01), whereas only EA was associated with FBMD (R = 0.554, p <.05); a positive association between EA and FBMD was found in MC (R = 0.464, p <.05). A negative relationship between VO2max and LSBMD in RC (R = -0.418, p <.05) and a positive one between EEE and LSBMD in MC were found (R = 0.605, p <.001). CaI, free testosterone and cortisol were unrelated to BMD. Conclusion: Both the RC and MC had lower LSBMD than C, whereas no difference was found between the two groups of cyclists. The factors associated with BMD are manifold, vary in relation to the measurement site and are likely different in RC, MC and C. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma

Author

Marcon, Alessandro, Marchetti, Pierpaolo, Antó, Josep M., Cazzoletti, Lucia, Cerveri, Isa, Corsico, Angelo, Ferreira, Diogenes Seraphim, Garcia-Aymerich, Judith, Gislason, David, Heinrich, Joachim, Jõgi, Rain, Johannessen, Ane, Leynaert, Bénédicte, Malinovschi, Andrei, Pin, Isabelle, Probst-Hensch, Nicole, Weyler, Joost, Janson, Christer, Jarvis, Deborah, and Accordini, Simone

Published
2020
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9. A stepped-wedge randomised controlled trial to assess efficacy and cost-effectiveness of a care-bundle to prevent falls in older hospitalised patients

Author

Di Gennaro, Gianfranco, primary, Chamitava, Liliya, additional, Pertile, Paolo, additional, Ambrosi, Elisa, additional, Mosci, Daniela, additional, Fila, Alice, additional, Alemayohu, Mulubirhan Assefa, additional, Cazzoletti, Lucia, additional, Tardivo, Stefano, additional, and Zanolin, Maria Elisabetta, additional

Published
2024
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11. Dietary flavonoids and ventilatory function in adults from the multinational Burden of Obstructive Lung Disease (BOLD) Study

Author

Alemayohu, Mulubirhan Assefa, primary, Zanolin, Maria Elisabetta, additional, Cazzoletti, Lucia, additional, El-Rhazi, Karima, additional, Hafizi, Hasan, additional, Nafees, Asaad Ahmed, additional, Gunasekera, Kirthi, additional, Anand, Mahesh Padukudru, additional, Sooronbayev, Talant, additional, Burney, Peter, additional, and Garcia-Larsen, Vanessa, additional

Published
2023
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13. #4427 USING REDUCED RANK REGRESSION TO INVESTIGATE THE RELATIONSHIP BETWEEN DIETARY PATTERNS AND ADULT KIDNEY FUNCTION IN THE GENERAL POPULATION

Author

Barbieri, Giulia, primary, Larsen, Vanessa Garcia, additional, Lundin, Rebecca, additional, Fujii, Ryosuke, additional, Melotti, Roberto, additional, Cazzoletti, Lucia, additional, Peter, Pramstaller, additional, Zanolin, Maria Elisabetta, additional, Pattaro, Cristian, additional, and Hantikainen, Essi Marjatta, additional

Published
2023
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14. A stepped-wedge randomised controlled trial to assess efficacy and cost-effectiveness of a care-bundle to prevent falls in older hospitalised patients.

Author

Gennaro, Gianfranco Di, Chamitava, Liliya, Pertile, Paolo, Ambrosi, Elisa, Mosci, Daniela, Fila, Alice, Alemayohu, Mulubirhan Assefa, Cazzoletti, Lucia, Tardivo, Stefano, and Zanolin, Maria Elisabetta

Subjects
EVALUATION of medical care, CONFIDENCE intervals, RANDOMIZED controlled trials, SEVERITY of illness index, ACCIDENTAL falls, HEALTH care teams, HOSPITAL care of older people, COST effectiveness, DESCRIPTIVE statistics, STATISTICAL sampling, DATA analysis software, ODDS ratio, ELDER care, OLD age
Abstract

Background Patient accidental falls in a hospital environment are a serious problem for patient safety, and for the additional costs due to associated medical interventions. Objective The endpoints of this study were the assessment of the fall incidence in the hospital before and after the implementation of a multidisciplinary care-bundle, along with a cost-effectiveness evaluation. Design A stepped-wedge trial was conducted between April 2015 and December 2016 in Bologna University Hospital. Methods Incidence rates (IRs) of falls in both the control and intervention periods were calculated. A multilevel mixed-effects generalised linear model with logit link function, adjusted for age, sex, cluster cross-over timing and patients' clinical severity was used to estimate odds ratios (OR) of fall risk of patients of the intervention group respect to the controls. Intervention costs associated with the introduction of the care-bundle intervention were spread between patients per cluster-period-group of exposure. Incremental cost-effectiveness ratio was evaluated using total costs in the intervention and control groups. Results IRs of falls in control and intervention periods were respectively 3.15 and 2.58 for 1,000 bed-days. After adjustment, the subjects receiving the intervention had a statistically significant reduced risk of falling with respect to those who did not (OR = 0.71, 95% confidence interval: 0.60–0.84). According to the cost-effectiveness analysis, the incremental cost per fall prevented was €873.92 considering all costs, and €1644.45 excluding costs related falls. Conclusions Care-bundle had a protective effect on patients, with a statistically significant reduction of the fall risk. This type of intervention appears cost-effective compared to routine practices. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Inhaled corticosteroids and risk of osteoporosis in late-middle-aged subjects: a multicenter European cohort study

Author

GROSSO, Amelia, primary, CERVERI, Isa, additional, CAZZOLETTI, Lucia, additional, ZANOLIN, Maria E., additional, MATTIOLI, Veronica, additional, PILONI, Davide, additional, GINI, Erica, additional, ALBICINI, Federica, additional, RONZONI, Vanessa, additional, JARVIS, Debbie, additional, JANSON, Christer, additional, and CORSICO, Angelo G., additional

Published
2023
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17. Inhaled corticosteroids and risk of osteoporosis in late-middle age subjects : a multicenter European cohort study

Author

Grosso, Amelia, Cerveri, Isa, Cazzoletti, Lucia, Zanolin, Maria E, Mattioli, Veronica, Piloni, Davide, Gini, Erica, Albicini, Federica, Ronzoni, Vanessa, Jarvis, Debbie, Janson, Christer, Corsico, Angelo G, Grosso, Amelia, Cerveri, Isa, Cazzoletti, Lucia, Zanolin, Maria E, Mattioli, Veronica, Piloni, Davide, Gini, Erica, Albicini, Federica, Ronzoni, Vanessa, Jarvis, Debbie, Janson, Christer, and Corsico, Angelo G

Abstract

BACKGROUND: Inhaled corticosteroids have been widely used for the regular treatment of asthma and COPD over the past few decades. To date, studies investigating the effects of ICS on bone in populations including asthma and COPD patients, show conflicting results. The skeletal effects of ICS remain poorly understood. We assessed the association between ICS exposure and self-reported osteoporosis diagnosis in a European cohort study. METHODS: The analysis was carried out by using clinical and questionnaire data available for subjects participating in the ECRHS III (European Community Respiratory Health Survey) with age >55 years. RESULTS: Among the 3004 enrolled subjects, 245 were ICS users with an exposure ≥12 months. Osteoporosis was reported by 16 subjects in the ICS group (6.5%) and by 167 in the not exposed group (6.1%). The adjusted risk of osteoporosis in ICS users (≥12 months) was not greater in exposed subjects when compared with the unexposed ones (OR=1.02, 95CI%: 0.51, 2.03). The same result was observed even when considering in the analysis a longer exposure to the ICS use (≥ 36.5 months, the median ICS exposure for all subjects). History of COPD, use of oral corticosteroids, Body Mass Index, smoking and physical activity did not show any evidence of an association with osteoporosis. CONCLUSIONS: Our study did not show any significant association between long- term ICS use and self-reported diagnosis of osteoporosis in subjects aged >55 years. To explore the real effect of ICS on bone status, further studies are needed, especially in the long-term ICS exposure.

Published
2023
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19. Patient safety subcultures among nursing home staff in Italy: a cross-sectional study

Author

Tocco Tussardi, Ilaria, Cazzoletti, Lucia, Zanolin, Maria Elisabetta, Comini, Annarita, Visentin, Donatella, Torri, Emanuele, Tardivo, Stefano, and Moretti, Francesca

Subjects
nursing home, patient safety, long-term care, professional subcultures, healthcare provider, Nursing Home Survey on Patient Safety Culture
Published
2023

20. Circulating eosinophil levels and lung function decline in stable chronic obstructive pulmonary disease: a retrospective longitudinal study

Author

Ferrari, Marcello, Pizzini, Michela, Cazzoletti, Lucia, Ermon, Valentina, Spelta, Francesco, De Marchi, Sergio, Carbonare, Luca Giuseppe Dalle, and Crisafulli, Ernesto

Subjects
Exacerbations, Declínio de VEF1, Biomarcadores, Eosinófilos no sangue, Exacerbações, COPD, FEV1 decline, DPOC, Blood eosinophils, Biomarkers
Abstract

RESUMO Objetivo Discute-se se eosinófilos no sangue (EOS) na doença pulmonar obstrutiva crônica (DPOC) são associados à evolução da doença. O objetivo deste estudo foi avaliar se a contagem diferencial de células brancas do sangue (CBS), os sintomas e o tratamento podem prever o declínio da função pulmonar e as exacerbações em pacientes com DPOC. Métodos Foram retrospectivamente examinados pacientes com DPOC estável submetidos a um monitoramento mínimo de três anos em nossas clínicas ambulatoriais. Coletaram-se informações sobre volumes pulmonares (VEF1 e CVF), contagens total e diferencial de CBS, exacerbações agudas de DPOC (número nos 12 meses anteriores ao início do estudo = EA-DPOC-B; e durante o monitoramento = EA-DPOC-F), status tabagístico e tratamento. Os declínios de VEF1 e EA-DPOC-F foram descritos empregando modelo linear generalizado e regressão binomial negativa com interceptação aleatória de nível 2, respectivamente. Os modelos incluíram contagens de eosinófilo e neutrófilo como potenciais preditores e foram ajustados de acordo com sexo, idade, status tabagístico, EA-DPOC-B, tratamento com broncodilatadores e corticosteroides inalados (CSI). Resultados 68 pacientes foram considerados, dos quais 36 para EOS- (< 170 células/μL, valor da mediana) e 32 para EOS+ (≥ 170 células/μL). ∆VEF1 foi maior em EOS+ do que em EOS- (34,86 mL/ano vs 4,49 mL/ano, p = 0,029). Após o ajuste em relação aos potenciais confundidores, as contagens de eosinófilos (β = 19,4; CI 95% 2,8,36,1; p = 0,022) e CSI (β = -57,7; CI 95% -91,5,-23,9; p = 0,001) foram positivamente e negativamente associadas ao declínio da função pulmonar, respectivamente. Os EOS não foram associados ao número de EA-DPOC-F. Conclusão Em pacientes com DPOC estável, o maior nível de EOS (embora em um intervalo regular) prevê um maior declínio de VEF1, enquanto os CSIs são associados a uma evolução mais lenta da obstrução do fluxo aéreo. ABSTRACT Objective Whether blood eosinophils (bEOS) in chronic obstructive pulmonary disease (COPD) are associated with disease progression is a topic of debate. We aimed to evaluate whether the differential white blood cell (WBC) count, symptoms and treatment may predict lung function decline and exacerbations in COPD patients. Methods We retrospectively examined stable COPD patients with a minimum follow-up of 3 years at our outpatients’ clinic. We collected information about lung volumes (FEV1, FVC), the total and differential WBC count, acute exacerbations of COPD (number in the 12 months before the beginning of the study=AE-COPD-B, and during the follow-up=AE-COPD-F), smoking status and treatment. FEV1 decline and AE-COPD-F were described by using a generalized linear model and a 2-level random intercept negative binomial regression, respectively. The models included eosinophil and neutrophil counts as potential predictors and were adjusted by sex, age, smoking status, AE-COPD-B, treatment with bronchodilators and inhaled corticosteroids (ICS). Results Sixty-eight patients were considered, 36 bEOS- (

Published
2022

21. Correction: Cazzoletti et al. Risk Factors Associated with Nursing Home COVID-19 Outbreaks: A Retrospective Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 8434

Author

Cazzoletti, Lucia, primary, Zanolin, Maria Elisabetta, additional, Tocco Tussardi, Ilaria, additional, Alemayohu, Mulubirhan Assefa, additional, Zanetel, Ernesto, additional, Visentin, Donatella, additional, Fabbri, Luca, additional, Giordani, Massimo, additional, Ruscitti, Giancarlo, additional, Benetollo, Pier Paolo, additional, Tardivo, Stefano, additional, and Torri, Emanuele, additional

Published
2021
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23. Risk Factors Associated with Nursing Home COVID-19 Outbreaks: A Retrospective Cohort Study

Author

Cazzoletti, Lucia, primary, Zanolin, Maria, additional, Tocco Tussardi, Ilaria, additional, Alemayohu, Mulubirhan, additional, Zanetel, Ernesto, additional, Visentin, Donatella, additional, Fabbri, Luca, additional, Giordani, Massimo, additional, Ruscitti, Giancarlo, additional, Benetollo, Pier, additional, Tardivo, Stefano, additional, and Torri, Emanuele, additional

Published
2021
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28. Inhaled Corticosteroids and Risk of Osteoporosis in Late-Middle Age Subjects: A Multicenter European Cohort Study

Author

Grosso, Amelia, primary, Piloni, Davide, additional, Zanolin, Maria Elisabetta, additional, Cazzoletti, Lucia, additional, Mattioli, Veronica, additional, Gini, Erica, additional, Albicini, Federica, additional, Ronzoni, Vanessa, additional, Cerveri, Isa, additional, Corsico, Angelo Guido, additional, Jarvis, Debbie, additional, and Janson, Christer, additional

Published
2020
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29. Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases

Author

Chamitava, Liliya, primary, Cazzoletti, Lucia, additional, Ferrari, Marcello, additional, Garcia-Larsen, Vanessa, additional, Jalil, Aneza, additional, Degan, Paolo, additional, Fois, Alessandro G., additional, Zinellu, Elisabetta, additional, Fois, Sara S., additional, Fratta Pasini, Anna Maria, additional, Nicolis, Morena, additional, Olivieri, Mario, additional, Corsico, Angelo, additional, Bono, Roberto, additional, Pirina, Pietro, additional, and Zanolin, Maria Elisabetta, additional

Published
2020
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32. Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases

Author

Ferrari, Marcello, primary, Piccinno, Elia, additional, Marcon, Alessandro, additional, Marchetti, Pierpaolo, additional, Cazzoletti, Lucia, additional, Pirina, Pietro, additional, Battaglia, Salvatore, additional, Grosso, Amelia, additional, Squillacioti, Giulia, additional, Antonicelli, Leonardo, additional, Verlato, Giuseppe, additional, and Pesce, Giancarlo, additional

Published
2019
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33. Additional file 1: of Health-related quality of life varies in different respiratory disorders: a multi-case control population based study

Author

Cappa, Veronica, Marcon, Alessandro, Gennaro, Gianfranco Di, Chamitava, Liliya, Cazzoletti, Lucia, Bombieri, Cristina, Nicolis, Morena, Perbellini, Luigi, Sembeni, Silvia, Marco, Roberto De, Spelta, Francesco, Ferrari, Marcello, and Zanolin, Maria

Abstract

Definition of cases and controls (a) and clinical tests (b). (DOCX 171 kb)

Published
2019
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34. Additional file 2: of Health-related quality of life varies in different respiratory disorders: a multi-case control population based study

Author

Cappa, Veronica, Marcon, Alessandro, Gennaro, Gianfranco Di, Chamitava, Liliya, Cazzoletti, Lucia, Bombieri, Cristina, Nicolis, Morena, Perbellini, Luigi, Sembeni, Silvia, Marco, Roberto De, Spelta, Francesco, Ferrari, Marcello, and Zanolin, Maria

Subjects
mental disorders, respiratory tract diseases
Abstract

Comorbidities among respiratory diseases. Figure S1. Comorbidities* between respiratory diseases and COPD cases. Figure S2. Comorbidities* between respiratory diseases and current asthma cases. Figure S3. Comorbidities* between respiratory diseases and past asthma cases. Figure S4. Comorbidities* between respiratory diseases and CB cases. (DOCX 117 kb)

Published
2019
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35. Pharmacological treatment of asthma in a cohort of adults during a 20-year period : results from the European Community Respiratory Health Survey I, II and III

Author

Janson, Christer, Accordini, Simone, Cazzoletti, Lucia, Cerveri, Isa, Chanoine, Sebastien, Corsico, Angelo, Ferreira, Diogenes Seraphim, Garcia-Aymerich, Judith, Gislason, David, Nielsen, Rune, Johannessen, Ane, Jõgi, Rain, Malinovschi, Andrei, Martinez-Moratalla Rovira, Jesús, Marcon, Alessandro, Pin, Isabelle, Quint, Jennifer, Siroux, Valerie, Almar, Enrique, Bellisario, Valeria, Franklin, Karl A, Gullón, José A, Holm, Mathias, Heinrich, Joachim, Nowak, Dennis, Sánchez-Ramos, José Luis, Weyler, Joost J, Jarvis, Deborah, Janson, Christer, Accordini, Simone, Cazzoletti, Lucia, Cerveri, Isa, Chanoine, Sebastien, Corsico, Angelo, Ferreira, Diogenes Seraphim, Garcia-Aymerich, Judith, Gislason, David, Nielsen, Rune, Johannessen, Ane, Jõgi, Rain, Malinovschi, Andrei, Martinez-Moratalla Rovira, Jesús, Marcon, Alessandro, Pin, Isabelle, Quint, Jennifer, Siroux, Valerie, Almar, Enrique, Bellisario, Valeria, Franklin, Karl A, Gullón, José A, Holm, Mathias, Heinrich, Joachim, Nowak, Dennis, Sánchez-Ramos, José Luis, Weyler, Joost J, and Jarvis, Deborah

Abstract

Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with the regular use of inhaled corticosteroid (ICS) treatment. Changes in the use of medication were determined in 4617 randomly selected subjects, while changes in adults with persistent asthma were analysed in 369 participants. The study compares data from three surveys in 24 centres in 11 countries. The use of ICSs increased from 1.7% to 5.9% in the general population and the regular use of ICSs increased from 19% to 34% among persistent asthmatic subjects. The proportion of asthmatic subjects reporting asthma attacks in the last 12 months decreased, while the proportion that had seen a doctor in the last 12 months remained unchanged (42%). Subjects with asthma who had experienced attacks or had seen a doctor were more likely to use ICSs on a regular basis. Although ICS use has increased, only one-third of subjects with persistent asthma take ICSs on a regular basis. Less than half had seen a doctor during the last year. This indicates that underuse of ICSs and lack of regular healthcare contacts remains a problem in the management of asthma.

Published
2019
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36. Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Author

Nerpin, Elisabet, Olivieri, Mario, Gislason, Thorainn, Olin, Anna C., Nielsen, Rune, Johannessen, Ane, Ferreira, Diogenes S., Marcon, Alessandro, Cazzoletti, Lucia, Accordini, Simone, Pin, Isabelle, Corsico, Angelo, Demoly, Pascal, Weyler, Joost, Nowak, Dennis, Jõgi, Rain, Forsberg, Bertil, Zock, Jan P., Sigsgaard, Torben, Heinric, Joachim, Bono, Roberto, Leynaert, Benedicte, Jarvis, Deborah, Janson, Christer, Malinovschi, Andrei, Nerpin, Elisabet, Olivieri, Mario, Gislason, Thorainn, Olin, Anna C., Nielsen, Rune, Johannessen, Ane, Ferreira, Diogenes S., Marcon, Alessandro, Cazzoletti, Lucia, Accordini, Simone, Pin, Isabelle, Corsico, Angelo, Demoly, Pascal, Weyler, Joost, Nowak, Dennis, Jõgi, Rain, Forsberg, Bertil, Zock, Jan P., Sigsgaard, Torben, Heinric, Joachim, Bono, Roberto, Leynaert, Benedicte, Jarvis, Deborah, Janson, Christer, and Malinovschi, Andrei

Abstract

Introduction The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective To identify determinants of FENO in men and women without lung diseases. Method Fractional exhaled nitric oxide was validly measured in 3881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease. Results Exhaled NO levels were 21.3% higher in men compared with women P < 0.001. Being in the upper age quartile (60.3-67.6 years), men had 19.2 ppb (95% CI: 18.3, 20.2) higher FENO than subjects in the lowest age quartile (39.7-48.3 years) P = 0.02. Women in the two highest age quartiles (54.6-60.2 and 60.3-67.6 years) had 15.4 ppb (14.7, 16.2), P = 0.03 and 16.4 ppb (15.6, 17.1), P = FENO, compared with the lowest age quartile. Height was related to 8% higher FENO level in men (P < 0.001) and 5% higher FENO levels in women (P = 0.008). Men who smoked had 37% lower FENO levels and women had 30% lower levels compared with never-smokers (P < 0.001 for both). Men and women sensitized to both grass and perennial allergens had higher FENO levels compared with non-sensitized subjects 26% and 29%, P Fractional exhaled nitric oxide levels were higher in men than women. Similar effects of current smoking, height, and IgE sensitization were found in both sexes. FENO started increasing at lower age in women than in men, suggesting that interpretation of FENO levels in adults aged over 50 years should take into account age and sex.

Published
2019
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42. Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III

Author

Janson, Christer, primary, Accordini, Simone, additional, Cazzoletti, Lucia, additional, Cerveri, Isa, additional, Chanoine, Sebastien, additional, Corsico, Angelo, additional, Ferreira, Diogenes Seraphim, additional, Garcia-Aymerich, Judith, additional, Gislason, David, additional, Nielsen, Rune, additional, Johannessen, Ane, additional, Jogi, Rain, additional, Malinovschi, Andrei, additional, Martinez-Moratalla Rovira, Jesús, additional, Marcon, Alessandro, additional, Pin, Isabelle, additional, Quint, Jennifer, additional, Siroux, Valerie, additional, Almar, Enrique, additional, Bellisario, Valeria, additional, Franklin, Karl A., additional, Gullón, José A., additional, Holm, Mathias, additional, Heinrich, Joachim, additional, Nowak, Dennis, additional, Sánchez-Ramos, José Luis, additional, Weyler, Joost J., additional, and Jarvis, Deborah, additional

Published
2019
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43. Cost variations of asthma over 10 years in adults

Author

Portas, Laura, Calciano, Lucia, Corsico, Angelo Guido, Cazzoletti, Lucia, Cerveri, Isa, Gerbase, Margaret W., Gislason, David, Gronseth, Rune, Heinrich, Joachim, Jögi, Rain, Johannessen, Ane, Marcon, Alessandro, Pin, Isabelle, Wacker, Margarethe, Jarvis, Deborah, Janson, Christer, Accordini, Simone, Portas, Laura, Calciano, Lucia, Corsico, Angelo Guido, Cazzoletti, Lucia, Cerveri, Isa, Gerbase, Margaret W., Gislason, David, Gronseth, Rune, Heinrich, Joachim, Jögi, Rain, Johannessen, Ane, Marcon, Alessandro, Pin, Isabelle, Wacker, Margarethe, Jarvis, Deborah, Janson, Christer, and Accordini, Simone

Abstract

Supplement: 62Meeting Abstract: PA3904

Published
2018
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44. Inhaled corticosteroids and FEV1 decline in asthma : an international cohort study

Author

Marcon, Alessandro, Marchetti, Pierpaolo, Anto, Josep M., Cazzoletti, Lucia, Cerveri, Isa, Corsico, Angelo, Garcia-Aymerich, Judith, Heinrich, Joachim, Gislason, David, Jogi, Rain, Johannessen, Ane, Leynaert, Benedicte, Malinovschi, Andrei, Pin, Isabelle, Weyler, Joost, Janson, Christer, Accordini, Simone, Jarvis, Deborah, Marcon, Alessandro, Marchetti, Pierpaolo, Anto, Josep M., Cazzoletti, Lucia, Cerveri, Isa, Corsico, Angelo, Garcia-Aymerich, Judith, Heinrich, Joachim, Gislason, David, Jogi, Rain, Johannessen, Ane, Leynaert, Benedicte, Malinovschi, Andrei, Pin, Isabelle, Weyler, Joost, Janson, Christer, Accordini, Simone, and Jarvis, Deborah

Abstract

Supplement: 62Meeting Abstract: OA295

Published
2018
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45. Asthma control and decline in FEV1/FVC ratio over 10 years in adults

Author

Accordini, Simone, Cazzoletti, Lucia, Anto, Josep, Cerveri, Isa, Corsico, Angelo, Garcia-Aymerich, Judith, Heinrich, Joachim, Gislason, David, Jogi, Rain, Johannessen, Ane, Leynaert, Benedicte, Malinovschi, Andrei, Pin, Isabelle, Portas, Laura, Weyler, Joost, Janson, Christer, Marcon, Alessandro, Jarvis, Deborah, Accordini, Simone, Cazzoletti, Lucia, Anto, Josep, Cerveri, Isa, Corsico, Angelo, Garcia-Aymerich, Judith, Heinrich, Joachim, Gislason, David, Jogi, Rain, Johannessen, Ane, Leynaert, Benedicte, Malinovschi, Andrei, Pin, Isabelle, Portas, Laura, Weyler, Joost, Janson, Christer, Marcon, Alessandro, and Jarvis, Deborah

Published
2018
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47. Determination of adjusted reference intervals of urinary biomarkers of oxidative stress in healthy adults using GAMLSS models

Author

Chamitava, Liliya, primary, Garcia-Larsen, Vanessa, additional, Cazzoletti, Lucia, additional, Degan, Paolo, additional, Pasini, Andrea, additional, Bellisario, Valeria, additional, Corsico, Angelo G., additional, Nicolis, Morena, additional, Olivieri, Mario, additional, Pirina, Pietro, additional, Ferrari, Marcello, additional, Stasinopoulos, Mikis D., additional, and Zanolin, Maria E., additional

Published
2018
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49. Cost variations of asthma over 10 years in adults

Author

Portas, Laura, primary, Calciano, Lucia, additional, Corsico, Angelo Guido, additional, Cazzoletti, Lucia, additional, Cerveri, Isa, additional, Gerbase, Margaret W, additional, Gislason, David, additional, Gronseth, Rune, additional, Heinrich, Joachim, additional, Jögi, Rain, additional, Johannessen, Ane, additional, Marcon, Alessandro, additional, Pin, Isabelle, additional, Wacker, Margarethe, additional, Jarvis, Deborah, additional, Janson, Christer, additional, and Accordini, Simone, additional

Published
2018
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50. Asthma control and decline in FEV1/FVC ratio over 10 years in adults

Author

Accordini, Simone, primary, Cazzoletti, Lucia, additional, Antó, Josep, additional, Cerveri, Isa, additional, Corsico, Angelo, additional, Garcia-Aymerich, Judith, additional, Heinrich, Joachim, additional, Gislason, David, additional, Jõgi, Rain, additional, Johannessen, Ane, additional, Leynaert, Bénédicte, additional, Malinovschi, Andrei, additional, Pin, Isabelle, additional, Portas, Laura, additional, Weyler, Joost, additional, Janson, Christer, additional, Marcon, Alessandro, additional, and Jarvis, Deborah, additional

Published
2018
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