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1. Comparing performance of year-round and campaign-mode influenza vaccination strategies among children aged 6–23 months in Kenya: 2019–2021

Author

Dawa, Jeanette, Jalang'o, Rose, Mirieri, Harriet, Kalani, Rosalia, Marwanga, Doris, Lafond, Kathryn E., Muriuki, Mary Margaret, Ejoi, Joyce, Chiguba, Faith, Patta, Shem, Amoth, Patrick, Okunga, Emmanuel, Tabu, Collins, Chaves, Sandra S., Ebama, Malembe S., Muthoka, Philip, Njenga, Virginia, Kiptoo, Elizabeth, Jewa, Isaac, Mwanyamawi, Raphael, Bresee, Joseph, Njenga, M. Kariuki, Osoro, Eric, Mecca, Lucy, and Emukule, Gideon O.

Published
2024
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5. Risk Analysis of Respiratory Syncytial Virus Among Infants in the United States by Birth Month

Author

Gantenberg, Jason R, primary, van Aalst, Robertus, additional, Reddy Bhuma, Monika, additional, Limone, Brendan, additional, Diakun, David, additional, Smith, David M, additional, Nelson, Christopher B, additional, Bengtson, Angela M, additional, Chaves, Sandra S, additional, La Via, William V, additional, Rizzo, Christopher, additional, Savitz, David A, additional, and Zullo, Andrew R, additional

Published
2024
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10. Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza

Author

Arriola, Carmen, Garg, Shikha, Anderson, Evan J, Ryan, Patrician A, George, Andrea, Zansky, Shelley M, Bennett, Nancy, Reingold, Arthur, Bargsten, Marisa, Miller, Lisa, Yousey-Hindes, Kimberly, Tatham, Lilith, Bohm, Susan R, Lynfield, Ruth, Thomas, Ann, Lindegren, Mary Lou, Schaffner, William, Fry, Alicia M, and Chaves, Sandra S

Subjects
Emerging Infectious Diseases, Immunization, Influenza, Clinical Research, Pneumonia & Influenza, Vaccine Related, Infectious Diseases, Prevention, Aging, Infection, Adolescent, Adult, Aged, Female, Humans, Influenza Vaccines, Influenza, Human, Male, Middle Aged, Propensity Score, Retrospective Studies, Severity of Illness Index, United States, Vaccination, Young Adult, Influenza vaccination, adults, disease severity, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundWe investigated the effect of influenza vaccination on disease severity in adults hospitalized with laboratory-confirmed influenza during 2013-14, a season in which vaccine viruses were antigenically similar to those circulating.MethodsWe analyzed data from the 2013-14 influenza season and used propensity score matching to account for the probability of vaccination within age strata (18-49, 50-64, and ≥65 years). Death, intensive care unit (ICU) admission, and hospital and ICU lengths of stay (LOS) were outcome measures for severity. Multivariable logistic regression and competing risk models were used to compare disease severity between vaccinated and unvaccinated patients, adjusting for timing of antiviral treatment and time from illness onset to hospitalization.ResultsInfluenza vaccination was associated with a reduction in the odds of in-hospital death among patients aged 18-49 years (adjusted odds ratios [aOR] = 0.21; 95% confidence interval [CI], 0.05 to 0.97), 50-64 years (aOR = 0.48; 95% CI, 0.24 to 0.97), and ≥65 years (aOR = 0.39; 95% CI, 0.17 to 0.66). Vaccination also reduced ICU admission among patients aged 18-49 years (aOR = 0.63; 95% CI, 0.42 to 0.93) and ≥65 years (aOR = 0.63; 95% CI, 0.48 to 0.81), and shortened ICU LOS among those 50-64 years (adjusted relative hazards [aRH] = 1.36; 95% CI, 1.06 to 1.74) and ≥65 years (aRH = 1.34; 95% CI, 1.06 to 1.73), and hospital LOS among 50-64 years (aRH = 1.13; 95% CI, 1.02 to 1.26) and ≥65 years (aRH = 1.24; 95% CI, 1.13 to 1.37).ConclusionsInfluenza vaccination during 2013-14 influenza season attenuated adverse outcome among adults that were hospitalized with laboratory-confirmed influenza.

Published
2017

11. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Author

Nair, Harish, Campbell, Harry, Wang, Xin, Li, You, Chung, Alexandria, Rahi, Manveer, Abbas, Qalab, Ali, Asad, Bhutta, Zulfiqar A, Saeed, Bushra, Soofi, Sajid B, Yousafzai, Mohammad Tahir, Zaidi, Anita K, Amu, Alberta, Awini, Elizabeth, Azziz-Baumgartner, Eduardo, Baggett, Henry C, Chaves, Sandra S, Shang, Nong, Schrag, Stephanie J, Widdowson, Marc-Alain, Tempia, Stefano, Bassat, Quique, Lanaspa, Miguel, Acácio, Sozinho, Brooks, W Abdullah, Driscoll, Amanda, Knoll, Maria Deloria, O'Brien, Katherine L, Prosperi, Christine, Baqui, Abdullah H, Mullany, Luke, Byass, Peter, Cohen, Cheryl, von Gottberg, Anne, Hellferscee, Orienka, Treurnicht, Florette K, Walaza, Sibongile, Goswami, Doli, Rahman, Mustafizur, Connor, Nicholas E, El Arifeen, Shams, Echavarria, Marcela, Marcone, Débora N, Reyes, Noelia, Gutierrez, Andrea, Rodriguez, Ivan, Lopez, Olga, Ortiz, David, Gonzalez, Nathaly, Gentile, Angela, del Valle Juarez, Maria, Gordon, Aubree, Cutland, Clare, Groome, Michelle, Madhi, Shabir A, Nunes, Marta C, Nzenze, Susan, Heikkinen, Terho, Hirve, Siddhivinayak, Juvekar, Sanjay, Halasa, Natasha, Jara, Jorge H, Bernart, Chris, Katz, Mark A, Gofer, Ilan, Avni, Yonat Shemer, Khuri-Bulos, Najwa, Faori, Samir, Shehabi, Asem, Krishnan, Anand, Kumar, Rakesh, Amarchand, Ritvik, Contreras, Carmen L, de Leon, Oscar, Lopez, Maria R, McCracken, John P, Maldonado, Herberth, Samayoa, Antonio P, Gomez, Ana B, Lucero, Marilla G, Nillos, Leilani T, Lupisan, Socorro P, Nohynek, Hanna, Mira-Iglesias, Ainara, Puig-Barberà, Joan, Díez-Domingo, Javier, Gessner, Bradford D, Njanpop-Lafourcade, Berthe-Marie, Moïsi, Jennifer C, Tall, Haoua, Munywoki, Patrick K, Ngama, Mwanjuma, Nokes, D James, Omer, Saad B, Clark, Dayna R, Ourohiré, Millogo, Ali, Sié, Pascal, Zabré, Cheik, Bagagnan H, Caballero, Mauricio T, Libster, Romina, Polack, Fernando P, Rasmussen, Zeba A, Thomas, Elizabeth D, Baker, Julia M, Rath, Barbara A, Obermeier, Patrick E, Hassanuzzaman, MD., Islam, Maksuda, Islam, Mohammad S, Saha, Samir K, Panigrahi, Pinaki, Bose, Anuradha, Isaac, Rita, Murdoch, David, Nanda, Pritish, Qazi, Shamim A, Hessong, Danielle, Simőes, Eric AF, Sotomayor, Viviana, Thamthitiwat, Somsak, Chittaganpitch, Malinee, Dawood, Halima, Kyobutungi, Catherine, Wamukoya, Marylene, Ziraba, Abdhalah K, Yoshida, Lay-Myint, Yoshihara, Keisuke, Dand, Duc-Anh, Le, Minh-Nhat, Nicol, Mark P, Zar, Heather J, Broor, Shobha, Chadha, Mandeep, Madrid, Lola, Gresh, Lionel, Balmaseda, Angel, Kuan, Guillermina, Wairagkar, Niteen, Tapia, Milagritos D, Knobler, Stacey L, Barahona, Alfredo, Ferguson, Ericka, Schweiger, Brunhilde, Abdullah Brooks, W, Fasce, Rodrigo A, and Simões, Eric AF

Published
2020
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13. Utility of Keywords from Chest Radiograph Reports for Pneumonia Surveillance among Hospitalized Patients with Influenza: The CDC Influenza Hospitalization Surveillance Network, 2008–2009

Author

Bramley, Anna M, Chaves, Sandra S, Dawood, Fatimah S, Doshi, Saumil, Reingold, Arthur, Miller, Lisa, Yousey-Hindes, Kimberly, Farley, Monica M, Ryan, Patricia, Lynfield, Ruth, Baumbach, Joan, Zansky, Shelley, Bennett, Nancy, Thomas, Ann, Schaffner, William, Finelli, Lyn, and Jain, Seema

Subjects
Health Services and Systems, Public Health, Health Sciences, Human Society, Policy and Administration, Lung, Prevention, Pneumonia & Influenza, Infectious Diseases, Influenza, Clinical Research, Pneumonia, Emerging Infectious Diseases, Infection, Centers for Disease Control and Prevention, U.S., Hospitalization, Humans, Influenza, Human, Observer Variation, Population Surveillance, Radiography, Thoracic, Reproducibility of Results, Terminology as Topic, United States, Nursing, Public Health and Health Services, Health services and systems, Public health, Policy and administration
Abstract

ObjectiveTranscripts from admission chest radiographs could aid in identification of pneumonia cases for public health surveillance. We assessed the reliability of radiographic data abstraction and performance of radiographic key terms to identify pneumonia in patients hospitalized with laboratory-confirmed influenza virus infection.MethodsWe used data on patients hospitalized with laboratory-confirmed influenza virus infection from October 2008 through December 2009 from 10 geographically diverse U.S. study sites participating in the Influenza Hospitalization Surveillance Network (FluSurv-NET). Radiographic key terms (i.e., bronchopneumonia, consolidation, infiltrate, airspace density, and pleural effusion) were abstracted from final impressions of chest radiograph reports. We assessed the reliability of radiographic data abstraction by examining the percent agreement and Cohen's k statistic between clinicians and surveillance staff members. Using a composite reference standard for presence or absence of pneumonia based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes and discharge summary data, we calculated sensitivity, specificity, positive predictive value (PPV), and percent agreement for individual and combined radiographic key terms.ResultsFor each radiographic key term, the percent agreement between clinicians and surveillance staff members ranged from 89.4% to 98.6% and Cohen's k ranged from 0.46 (moderate) to 0.84 (almost perfect). The combination of bronchopneumonia or consolidation or infiltrate or airspace density terms had sensitivity of 66.5%, specificity of 89.2%, PPV of 80.4%, and percent agreement of 80.1%. Adding pleural effusion did not result in significant changes in sensitivity, specificity, PPV, or percent agreement.ConclusionRadiographic key terms abstracted by surveillance staff members from final impressions of chest radiograph reports had moderate to almost perfect reliability and could be used to identify pneumonia among patients hospitalized with laboratory-confirmed influenza virus infection. This method can inform pneumonia surveillance and aid in public health response.

Published
2016

17. Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States

Author

Arriola, Carmen S, Anderson, Evan J, Baumbach, Joan, Bennett, Nancy, Bohm, Susan, Hill, Mary, Lindegren, Mary Lou, Lung, Krista, Meek, James, Mermel, Elizabeth, Miller, Lisa, Monroe, Maya L, Morin, Craig, Oni, Oluwakemi, Reingold, Arthur, Schaffner, William, Thomas, Ann, Zansky, Shelley M, Finelli, Lyn, and Chaves, Sandra S

Subjects
Emerging Infectious Diseases, Immunization, Lung, Prevention, Pneumonia & Influenza, Patient Safety, Influenza, Aging, Vaccine Related, Infectious Diseases, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, Infection, Aged, Female, Hospitalization, Humans, Influenza Vaccines, Influenza, Human, Intensive Care Units, Logistic Models, Male, Middle Aged, Pneumonia, Seasons, Severity of Illness Index, United States, Vaccination, adults, influenza, influenza vaccine, severe illness, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundSome studies suggest that influenza vaccination might be protective against severe influenza outcomes in vaccinated persons who become infected. We used data from a large surveillance network to further investigate the effect of influenza vaccination on influenza severity in adults aged ≥50 years who were hospitalized with laboratory-confirmed influenza.MethodsWe analyzed influenza vaccination and influenza severity using Influenza Hospitalization Surveillance Network (FluSurv-NET) data for the 2012-2013 influenza season. Intensive care unit (ICU) admission, death, diagnosis of pneumonia, and hospital and ICU lengths of stay served as measures of disease severity. Data were analyzed by multivariable logistic regression, parametric survival models, and propensity score matching (PSM).ResultsOverall, no differences in severity were observed in the multivariable logistic regression model. Using PSM, adults aged 50-64 years (but not other age groups) who were vaccinated against influenza had a shorter length of ICU stay than those who were unvaccinated (hazard ratio for discharge, 1.84; 95% confidence interval, 1.12-3.01).ConclusionsOur findings show a modest effect of influenza vaccination on disease severity. Analysis of data from seasons with different predominant strains and higher estimates of vaccine effectiveness are needed.

Published
2015

19. Surveillance of respiratory viruses at health facilities from across Kenya, 2014

Author

Murunga, Nickson, primary, Nyawanda, Bryan, additional, Nyiro, Joyce U., additional, Otieno, Grieven P., additional, Kamau, Everlyn, additional, Agoti, Charles N., additional, Lewa, Clement, additional, Gichuki, Alex, additional, Mutunga, Martin, additional, Otieno, Nancy, additional, Mayieka, Lilian, additional, Ochieng, Melvin, additional, Kikwai, Gilbert, additional, Hunsperger, Elizabeth, additional, Onyango, Clayton, additional, Emukule, Gideon, additional, Bigogo, Godfrey, additional, Verani, Jennifer R., additional, Chaves, Sandra S., additional, Nokes, D. James, additional, and Munywoki, Patrick K., additional

Published
2023
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20. Predictors of Severity of Influenza-Related Hospitalizations: Results From the Global Influenza Hospital Surveillance Network (GIHSN)

Author

Cohen, Lily E, primary, Hansen, Chelsea L, additional, Andrew, Melissa K, additional, McNeil, Shelly A, additional, Vanhems, Philippe, additional, Kyncl, Jan, additional, Domingo, Javier Díez, additional, Zhang, Tao, additional, Dbaibo, Ghassan, additional, Laguna-Torres, Victor Alberto, additional, Draganescu, Anca, additional, Baumeister, Elsa, additional, Gomez, Doris, additional, Raboni, Sonia M, additional, Giamberardino, Heloisa I G, additional, Nunes, Marta C, additional, Burtseva, Elena, additional, Sominina, Anna, additional, Medić, Snežana, additional, Coulibaly, Daouda, additional, Salah, Afif Ben, additional, Otieno, Nancy A, additional, Koul, Parvaiz A, additional, Unal, Serhat, additional, Tanriover, Mine Durusu, additional, Mazur, Marie, additional, Bresee, Joseph, additional, Viboud, Cecile, additional, and Chaves, Sandra S, additional

Published
2023
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23. Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015

Author

Appiah, Grace D., Chaves, Sandra S., Kirley, Pam D., Miller, Lisa, Meek, James, Anderson, Evan, Oni, Oluwakemi, Ryan, Patricia, Eckel, Seth, Lynfield, Ruth, Bargsten, Marisa, Zansky, Shelley M., Bennett, Nancy, Lung, Krista, McDonald-Hamm, Christie, Thomas, Ann, Brady, Diane, Lindegren, Mary L., Schaffner, William, Hill, Mary, Garg, Shikha, Fry, Alicia M., and Campbell, Angela P.

Published
2017

25. Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network

Author

Andrew, Melissa K, primary, Pott, Henrique, additional, Staadegaard, Lisa, additional, Paget, John, additional, Chaves, Sandra S, additional, Ortiz, Justin R, additional, McCauley, John, additional, Bresee, Joseph, additional, Nunes, Marta C, additional, Baumeister, Elsa, additional, Raboni, Sonia Mara, additional, Giamberardino, Heloisa I G, additional, McNeil, Shelly A, additional, Gomez, Doris, additional, Zhang, Tao, additional, Vanhems, Philippe, additional, Koul, Parvaiz A, additional, Coulibaly, Daouda, additional, Otieno, Nancy A, additional, Dbaibo, Ghassan, additional, Almeida, Maria Lourdes Guerrero, additional, Laguna-Torres, Victor Alberto, additional, Drăgănescu, Anca Cristina, additional, Burtseva, Elena, additional, Sominina, Anna, additional, Danilenko, Daria, additional, Medić, Snežana, additional, Diez-Domingo, Javier, additional, and Lina, Bruno, additional

Published
2023
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28. Global, regional and national estimates of influenza-attributable ischemic heart disease mortality

Author

Chaves, Sandra S., Nealon, Joshua, Burkart, Katrin G., Modin, Daniel, Biering-Sørensen, Tor, Ortiz, Justin R., Vilchis-Tella, Victor M., Wallace, Lindsey E., Roth, Gregory, Mahe, Cedric, Brauer, Michael, Chaves, Sandra S., Nealon, Joshua, Burkart, Katrin G., Modin, Daniel, Biering-Sørensen, Tor, Ortiz, Justin R., Vilchis-Tella, Victor M., Wallace, Lindsey E., Roth, Gregory, Mahe, Cedric, and Brauer, Michael

Abstract

Background: Influenza virus infection is associated with incident ischemic heart disease (IHD) events. Here, we estimate the global, regional, and national IHD mortality burden attributable to influenza. Methods: We used vital registration data from deaths in adults ≥50 years (13.2 million IHD deaths as underlying cause) to assess the relationship between influenza activity and IHD mortality in a non-linear meta-regression framework from 2010 to 2019. This derived relationship was then used to estimate the global influenza attributable IHD mortality. We estimated the population attributable fraction (PAF) of influenza for IHD deaths based on the relative risk associated with a given level of weekly influenza test positivity rate and multiplied PAFs by IHD mortality from the Global Burden of Disease study. Findings: Influenza activity was associated with increased risk of IHD mortality across all countries analyzed. The mean PAF of influenza for IHD mortality was 3.9% (95% uncertainty interval [UI] 2.5–5.3%), ranging from <1% to 10%, depending on country and year. Globally, 299,858 IHD deaths (95% UI 191,216–406,809) in adults ≥50 years could be attributed to influenza, with the highest rates per 100,000 population in the Central Europe, Eastern Europe and Central Asia Region (32.3; 95% UI 20.6–43.8), and in the North Africa and Middle East Region (26.7; 95% UI 17–36.2). Interpretation: Influenza may contribute substantially to the burden of IHD. Our results suggest that if there were no influenza, an average of 4% of IHD deaths globally would not occur. Funding: Collaborative study funded by Sanofi Vaccines.

Published
2023

33. Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis

Author

Lafond, Kathryn E., Porter, Rachael M., Whaley, Melissa J., Suizan, Zhou, Ran, Zhang, Aleem, Mohammad Abdul, Thapa, Binay, Sar, Borann, Proschle, Viviana Sotomayor, Peng, Zhibin, Feng, Luzhao, Coulibaly, Daouda, Nkwembe, Edith, Olmedo, Alfredo, Ampofo, William, Saha, Siddhartha, Chadha, Mandeep, Mangiri, Amalya, Setiawaty, Vivi, Ali, Sami Sheikh, Chaves, Sandra S., Otorbaeva, Dinagul, Keosavanh, Onechanh, Saleh, Majd, Ho, Antonia, Alexander, Burmaa, Oumzil, Hicham, Baral, Kedar Prasad, Huang, Q. Sue, Adebayo, Adedeji A., Al-Abaidani, Idris, von Horoch, Marta, Cohen, Cheryl, Tempia, Stefano, Mmbaga, Vida, Chittaganpitch, Malinee, Casal, Mariana, Dang, Duc Anh, Couto, Paula, Nair, Harish, Bresee, Joseph S., Olsen, Sonja J., Azziz-Baumgartner, Eduardo, Nuorti, J. Pekka, and Widdowson, Marc-Alain

Subjects
World health -- Research, Medical research, Medicine, Experimental, Influenza -- Complications and side effects, Respiratory tract infections -- Causes of -- Care and treatment -- Statistics, Biological sciences
Abstract

Background Influenza illness burden is substantial, particularly among young children, older adults, and those with underlying conditions. Initiatives are underway to develop better global estimates for influenza-associated hospitalizations and deaths. Knowledge gaps remain regarding the role of influenza viruses in severe respiratory disease and hospitalizations among adults, particularly in lower-income settings. Methods and findings We aggregated published data from a systematic review and unpublished data from surveillance platforms to generate global meta-analytic estimates for the proportion of acute respiratory hospitalizations associated with influenza viruses among adults. We searched 9 online databases (Medline, Embase, CINAHL, Cochrane Library, Scopus, Global Health, LILACS, WHOLIS, and CNKI; 1 January 1996-31 December 2016) to identify observational studies of influenza-associated hospitalizations in adults, and assessed eligible papers for bias using a simplified Newcastle-Ottawa scale for observational data. We applied meta-analytic proportions to global estimates of lower respiratory infections (LRIs) and hospitalizations from the Global Burden of Disease study in adults [greater than or equal to]20 years and by age groups (20-64 years and [greater than or equal to]65 years) to obtain the number of influenza-associated LRI episodes and hospitalizations for 2016. Data from 63 sources showed that influenza was associated with 14.1% (95% CI 12.1%-16.5%) of acute respiratory hospitalizations among all adults, with no significant differences by age group. The 63 data sources represent published observational studies (n = 28) and unpublished surveillance data (n = 35), from all World Health Organization regions (Africa, n = 8; Americas, n = 11; Eastern Mediterranean, n = 7; Europe, n = 8; Southeast Asia, n = 11; Western Pacific, n = 18). Data quality for published data sources was predominantly moderate or high (75%, n = 56/75). We estimate 32,126,000 (95% CI 20,484,000-46,129,000) influenza-associated LRI episodes and 5,678,000 (95% CI 3,205,000-9,432,000) LRI hospitalizations occur each year among adults. While adults Conclusions In this meta-analysis, we estimated that influenza viruses are associated with over 5 million hospitalizations worldwide per year. Inclusion of both published and unpublished findings allowed for increased power to generate stratified estimates, and improved representation from lower-income countries. Together, the available data demonstrate the importance of influenza viruses as a cause of severe disease and hospitalizations in younger and older adults worldwide., Author(s): Kathryn E. Lafond 1,2,*, Rachael M. Porter 1, Melissa J. Whaley 3, Zhou Suizan 4, Zhang Ran 4, Mohammad Abdul Aleem 5, Binay Thapa 6, Borann Sar 7, Viviana [...]

Published
2021
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36. Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya

Author

Hunsperger, Elizabeth, Juma, Bonventure, Onyango, Clayton, Ochieng, John B., Omballa, Victor, Fields, Barry S., Njenga, M. Kariuki, Mwangi, Jane, Bigogo, Godfrey, Omore, Richard, Otieno, Nancy, Chaves, Sandra S., Munyua, Peninah, Njau, Daniel Macharia, Verani, Jennifer, Lowther, Sara, Breiman, Robert F., Montgomery, Joel M, De Cock, Kevin M., Widdowson, Marc-Alain, and CDC and KEMRI Laboratory and Epidemiology Team

Published
2019
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38. Global and national influenza-associated hospitalisation rates: Estimates for 40 countries and administrative regions

Author

Paget, John, primary, Staadegaard, Lisa, additional, Wang, Xin, additional, Li, You, additional, van Pomeren, Tayma, additional, van Summeren, Jojanneke, additional, Dückers, Michel, additional, Chaves, Sandra S, additional, Johnson, Emily K, additional, Mahé, Cédric, additional, Nair, Harish, additional, Viboud, Cecile, additional, and Spreeuwenberg, Peter, additional

Published
2023
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40. Increased severity of influenza-associated hospitalizations in resource-limited settings: Results from the Global Influenza Hospital Surveillance Network (GIHSN)

Author

Cohen, Lily E, primary, Hansen, Chelsea, additional, Andrew, Melissa K, additional, McNeil, Shelly A, additional, Vanhems, Philippe, additional, Kyncl, Jan, additional, Díez Domingo, Javier, additional, Zhang, Tao, additional, Dbaibo, Ghassan, additional, Laguna-Torres, Victor Alberto, additional, Draganescu, Anca, additional, Baumeister, Elsa, additional, Gomez, Doris, additional, Raboni, Sonia M, additional, Giamberardino, Heloisa I G, additional, Nunes, Marta C, additional, Burtseva, Elena, additional, Sominina, Anna, additional, Medić, Snežana, additional, Coulibaly, Daouda, additional, Salah, Afif Ben, additional, Otieno, Nancy A, additional, Koul, Parvaiz A, additional, Unal, Serhat, additional, Tanriover, Mine Durusu, additional, Mazur, Marie, additional, Bresee, Joseph, additional, Viboud, Cecile, additional, and Chaves, Sandra S, additional

Published
2022
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41. Age differences in comorbidities, presenting symptoms, and outcomes of influenza illness requiring hospitalization: A worldwide perspective from the global influenza hospital surveillance network

Author

Andrew, Melissa K, Pott, Henrique, Staadegaard, Lisa, Paget, John, Chaves, Sandra S, Ortiz, Justin R, McCauley, John, Bresee, Joseph, Nunes, Marta C, Baumeister, Elsa, Raboni, Sonia Mara, Giamberardino, Heloisa IG, McNeil, Shelly A, Gomez, Doris, Zhang, Tao, Vanhems, Philippe, Koul, Parvaiz A, Coulibaly, Daouda, Otieno, Nancy A, Dbaibo, Ghassan, Almeida, Maria Lourdes Guerrero, Laguna-Torres, Victor Alberto, Drăgănescu, Anca Cristina, Burtseva, Elena, Sominina, Anna, Danilenko, Daria, Medić, Snežana, Diez-Domingo, Javier, Lina, Bruno, and Investigators, on behalf of GIHSN

Subjects
Ecology,Evolution & Ethology, Infectious Disease
Abstract

Background. The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes in patients hospitalized with influenza. Methods. Between November 2018 and October 2019, GIHSN included 19 sites in 18 countries using a standardized surveillance protocol. Influenza infection was laboratory-confirmed with reverse-transcription polymerase chain reaction. A multivariate logistic regression model was utilized to analyze the extent to which various risk factors predict severe outcomes. Results. Of 16 022 enrolled patients, 21.9% had laboratory-confirmed influenza; 49.2% of influenza cases were A/ H1N1pdm09. Fever and cough were the most common symptoms, although they decreased with age (P < .001). Shortness of breath was uncommon among those

Published
2023
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42. Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012-2013 Season in the United States

Author

Arriola, Carmen S., Anderson, Evan J., Baumbach, Joan, Bennett, Nancy, Bohm, Susan, Hill, Mary, Lindegren, Mary Lou, Lung, Krista, Meek, James, Mermel, Elizabeth, Miller, Lisa, Monroe, Maya L., Morin, Craig, Oni, Oluwakemi, Reingold, Arthur, Schaffner, William, Thomas, Ann, Zansky, Shelley M., Finelli, Lyn, and Chaves, Sandra S.

Published
2015

44. Update : Influenza Activity — United States, September 28, 2014–February 21, 2015

Author

World Health Organization Collaborating Center for Surveillance, Epidemiology, and Control of Influenza, D’Mello, Tiffany, Brammer, Lynnette, Blanton, Lenee, Kniss, Krista, Smith, Sophie, Mustaquim, Desiree, Steffens, Craig, Dhara, Rosaline, Cohen, Jessica, Chaves, Sandra S., Finelli, Lyn, Bresee, Joseph, Wallis, Teresa, Xu, Xiyan, Elal, Anwar Isa Abd, Gubareva, Larisa, Wentworth, David, Villanueva, Julie, Katz, Jackie, and Jernigan, Daniel

Published
2015

45. Update : Influenza Activity — United States, September 28–December 6, 2014

Author

Rolfes, Melissa, Blanton, Lenee, Brammer, Lynnette, Smith, Sophie, Mustaquim, Desiree, Steffens, Craig, Cohen, Jessica, Leon, Michelle, Chaves, Sandra S., Elal, Anwar Isa Abd, Gubareva, Larisa, Hall, Henrietta, Wallis, Teresa, Villanueva, Julie, Xu, Xiyan, Bresee, Joseph, Cox, Nancy, and Finelli, Lyn

Published
2014

48. Surveillance of respiratory viruses at health facilities from across Kenya, 2014

Author

Murunga, Nickson, primary, Nyawanda, Bryan, additional, Nyiro, Joyce U., additional, Otieno, Grieven P., additional, Kamau, Everlyn, additional, Agoti, Charles N., additional, Lewa, Clement, additional, Gichuki, Alex, additional, Mutunga, Martin, additional, Otieno, Nancy, additional, Mayieka, Lilian, additional, Ochieng, Melvin, additional, Kikwai, Gilbert, additional, Hunsperger, Elizabeth, additional, Onyango, Clayton, additional, Emukule, Gideon, additional, Bigogo, Godfrey, additional, Verani, Jennifer R., additional, Chaves, Sandra S., additional, Nokes, D. James, additional, and Munywoki, Patrick K., additional

Published
2022
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49. Medically Attended Illness due to Respiratory Syncytial Virus Infection Among Infants Born in the United States Between 2016 and 2020

Author

Gantenberg, Jason R, primary, van Aalst, Robertus, additional, Zimmerman, Nicole, additional, Limone, Brendan, additional, Chaves, Sandra S, additional, La Via, William V, additional, Nelson, Christopher B, additional, Rizzo, Christopher, additional, Savitz, David A, additional, and Zullo, Andrew R, additional

Published
2022
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