379 results on '"Chen, Alex F."'
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2. Functions, Mechanisms, and therapeutic applications of the inositol pyrophosphates 5PP-InsP5 and InsP8 in mammalian cells
3. O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
4. Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy
5. LXRα Promotes Abdominal Aortic Aneurysm Formation Through UHRF1 Epigenetic Modification of miR-26b-3p
6. Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia
7. Low-dose nifedipine rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice
8. S1PR2/Wnt3a/RhoA/ROCK1/β-catenin signaling pathway promotes diabetic nephropathy by inducting endothelial mesenchymal transition and impairing endothelial barrier function
9. Plasma metabolic fingerprints for large-scale screening and personalized risk stratification of metabolic syndrome
10. Sema3G activates YAP and promotes VSMCs proliferation and migration via Nrp2/PlexinA1
11. Contributors
12. Berberine hydrochloride inhibits migration ability via increasing inducible NO synthase and peroxynitrite in HTR-8/SVneo cells
13. The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis
14. Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression
15. Identification and experimental validation of PYCARD as a crucial PANoptosis- related gene for immune response and inflammation in COPD
16. LXRα Promotes Abdominal Aortic Aneurysm Formation Through UHRF1 Epigenetic Modification of miR-26b-3p.
17. HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production
18. R-spondin 3 inhibits high glucose-induced endothelial activation through LGR4/Wnt/β-catenin pathway
19. Identification of Ferroptosis-Related Hub Genes Associated with Immune Infiltration in Sepsis by Bioinformatics Analysis and in Vivo Validation
20. Discovery of novel p90 ribosomal S6 kinase 2 inhibitors for potential cancer treatment through ligand-based and structure-based virtual screening methods
21. O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
22. R-spondin 3 Inhibits High Glucose-Induced Endothelial Activation Through Leucine-Rich G Protein-Coupled Receptor 4/Wnt/β-catenin Pathway
23. Induced pluripotent stem cells attenuate chronic allogeneic vasculopathy in an integrin beta-1-dependent manner
24. A multi-scale systems pharmacology approach uncovers the anti-cancer molecular mechanism of Ixabepilone
25. Functions, Mechanisms, and therapeutic applications of the inositol pyrophosphates 5PP-InsP5 and InsP8 in mammalian cells.
26. Caspase-4/11–Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension
27. Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells During Cardiac Fibrosis
28. Cardioprotective mechanisms of salvianic acid A sodium in rats with myocardial infarction based on proteome and transcriptome analysis
29. Multistep virtual screening for rapid identification of G Protein-Coupled Receptors Kinase 2 inhibitors for heart failure treatment
30. The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling
31. Preeclampsia serum induces human glomerular vascular endothelial cell hyperpermeability via the HMGB1-Caveolin-1 pathway
32. Sodium dichloroacetate improves migration ability by suppressing LPS-induced inflammation in HTR-8/SVneo cells via the TLR4/NF-B pathway.
33. Aging-Associated ALKBH5-m6A Modification Exacerbates Doxorubicin-Induced Cardiomyocyte Apoptosis Via AT-Rich Interaction Domain 2.
34. iPSC-derived exosomes promote angiogenesis in naturally aged mice
35. Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice
36. A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus
37. ChemBCPP: A freely available web server for calculating commonly used physicochemical properties
38. ADME properties evaluation in drug discovery: Prediction of plasma protein binding using NSGA-II combining PLS and consensus modeling
39. Synergistic augmentation of osimertinib‐induced autophagic death by proguanil or rapamycin in bladder cancer
40. ASGR1 promotes liver injury in sepsis by modulating monocyte-to-macrophage differentiation via NF-κB/ATF5 pathway
41. Induction of KLF2 by Exercise Activates eNOS to Improve Vasodilatation in Diabetic Mice.
42. The peptide lycosin-I attenuates TNF-α-induced inflammation in human umbilical vein endothelial cells via IκB/NF-κB signaling pathway
43. ChemSAR: an online pipelining platform for molecular SAR modeling
44. Deficiency of Sox7 Leads to Congenital Aortic Stenosis via Abnormal Valve Remodeling
45. Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans
46. HIV protease inhibitors in pulmonary hypertension: rationale and design of a pilot trial in idiopathic pulmonary arterial hypertension
47. In silico toxicity prediction of chemicals from EPA toxicity database by kernel fusion-based support vector machines
48. S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1
49. Synergistic augmentation of osimertinib-induced autophagic death by proguanil or rapamycin in bladder cancer.
50. The beneficial effects of alpha‐tocopherol on intestinal function and the expression of tight junction proteins in differentiated segments of the intestine in piglets
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