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Collaborative problem-solving (CPS) engages students in solving ill-structured problems, creating group knowledge, and developing self-regulation and collaboration skills. Different scaffoldings, such as minimal-guided, task-oriented, and idea-oriented, can be used to facilitate students' CPS activities, but their effects have not been comprehensively explored. In this research, we use minimally-guided, task-oriented, and idea-oriented scaffoldings to promote Chinese university students' online CPS activities and use a multi-method approach to analyze the effects of three scaffolding on collaboration. The results indicate relatively complicated collaborative processes and outcomes supported by three scaffoldings. It is initially shown that the idea-centered scaffolding strengthens students' connections between idea contribution, metacognitive regulation, and knowledge artifact behaviors, which are critical factors for improving the CPS quality. Based on the empirical research results, we conclude that future instructional design should carefully consider the educational culture, time constraint, and student regulation to better facilitate CPS practices.

Aim: This study aims to investigate the influence of medical explainable artificial intelligence (XAI) on the innovation behaviour of nurses, as well as explore the dual‐pathway mediating effect of AI self‐efficacy and AI anxiety and organizational ethical climate as the moderating effect. Background: To address the practical application of medical AI technology, alleviate the scarcity of medical resources and fulfil the medical and health demands of the public, it is crucial to improve the innovation behaviour of nurses through the use of medical XAI. Methods: A cross‐sectional survey was conducted involving 368 Chinese nurses working at tertiary and secondary hospitals in Anhui Province, Jiangsu Province, Zhejiang Province and Shanghai. Results: Implementing medical XAI significantly enhanced the innovation behaviour of nurses. Anxiety and self‐efficacy regarding AI mediated the connection between medical XAI and the innovation behaviour of nurses. Furthermore, the organizational ethical climate positively moderated the relationship between medical XAI and AI self‐efficacy. Conclusion: Medical XAI helps to enhance nurses' AI self‐efficacy and reduce AI anxiety, thereby enhancing nurses' innovation behaviour. An organizational ethical climate enhances the positive relationship between medical XAI and AI self‐efficacy. Implications for Nursing Management: Organizations and technology developers must augment the study about XAI and the system design of human‐centred AI technology. The organizations aim to enhance the education and training of nurses in AI, specifically focussing on boosting nurses' self‐efficacy in utilizing AI technology. Moreover, they want to alleviate nurses' fear of new technological advancements. Hospital administrators and leaders develop strategies to address the ethical atmosphere inside their organization. [ABSTRACT FROM AUTHOR]

Background: Cholestasis is a common yet severe complication that occurs during the advancement of liver metastasis. However, how cholestasis impacts the development, treatment, and tumor microenvironment (TME) of liver metastasis remains to be elucidated. Methods: Extrahepatic and intrahepatic cholestatic mouse models with liver metastasis were established to detect the differential expression levels of genes, infiltration of immune cells and change in bile acid-associated metabolites by using RNA-Sequencing, flowcytometry, and liquid chromatography and mass spectrometry. Western blot was applied to neutrophils under the stimulation of primary bile acids (BAs) in vitro to study the mechanism of phenotypic alteration. In vitro coculture of BA-treated neutrophils with CD8+ T cells were performed to study the immune-suppressive effect of phenotypic-altered neutrophils. Clinical samples collected from colorectal cancer patients with liver metastasis and cholestasis were applied to RNA-Seq. Results: Compared to non-cholestatic mice, the progression of liver metastasis of cholestatic mice was significantly accelerated, which was associated with increased neutrophil infiltration and T-cell exclusion. Both neutrophils and T cells expressed higher immunosuppressive markers in the cholestatic mouse model, further indicating that an immunosuppressive tumor microenvironment was induced during cholestasis. Although neutrophils deletion via anti-Ly6G antibody partially hindered liver metastasis progression, it reduced the overall survival of mice. Tauro-β-muricholic acid (Tβ-MCA) and Glycocholic acid (GCA), the two most abundant cholestasis-associated primary BAs, remarkably promoted the expression of Arg1 and iNOS on neutrophils via p38 MAPK signaling pathway. In addition, BAs-pretreated neutrophils significantly suppressed the activation and cytotoxic effects of CD8+ T cells, indicating that the immunosuppressive phenotype of neutrophils was directly induced by BAs. Importantly, targeting BA anabolism with Obeticholic acid (OCA) under cholestasis effectively suppressed liver metastasis progression, enhanced the efficacy of immune checkpoint blockade, and prolonged survival of mice. Conclusions: Our study reveals the TME of cholestasis-associated liver metastasis and proposes a new strategy for such patients by targeting bile acid anabolism. Schematic model depicting the proposed mechanism of cholestasis-mediated progression of colorectal liver metastasis. As cholestasis progresses, excessive primary bile acids that accumulate in the liver intoxicates hepatocytes, which lead to exacerbated release of chemokines, particularly CXCL2 and CXCL5. Neutrophils are then accumulated by CXCL2 and CXCL5 and undergo an immunosuppressive-phenotypic alteration induced by direct stimulation of BAs via activating the p38 MAPK signaling pathway, which eventually led to the dysfunction of T cells and progression of LM. Targeting bile acid anabolism can effectively restore the immune-activated microenvironment and prevent the progression of LM. [ABSTRACT FROM AUTHOR]

The renewable nature, high carbon content, and unique hierarchical structure of wood-derived carbon make it an optimal self-supporting electrode for energy storage. However, the limitations in specific surface area and electrical conductivity defects pose challenges to achieving satisfactory charge storage in wood-derived carbon electrodes. Therefore, exploring diverse and effective surface strategies is crucial for enhancing the electrochemical energy storage performance. Herein, a decoration technique for enhancing aesthetic appeal involves applying a metal-organic framework (Ni/Co-MOF) containing nickel and cobalt onto the inner walls of wood tracheids. The sequential modification steps include carbonization, oxidation activation, and acid-etching. The Ni/NiO/CoO-CW-4 electrode, made by acid-etching carbonized wood (CW) doped with nickel, nickel oxide, and cobalt oxide for 4 h, has excellent surface area and pore size distribution, high graphitization degree, and exceptional conductivity. Furthermore, surface modification optimizes the surface chemistry and phase composition, resulting in a 0.8 mm thick Ni/NiO/CoO-CW-4 electrode with an exceptionally high areal capacitance of 16.76 F cm -2 at 5 mA cm -2 . Meanwhile, the fabricated solid-state supercapacitor achieves an impressive energy density of 0.67 mWh cm -2 (8.38 mWh cm -3 ) at 2.5 mW cm -2 (31.25 mW cm -3 ), surpassing representative modified wood-based carbon electrodes by approximately 2-7 times. Additionally, the supercapacitor demonstrates exceptional stability, maintaining 96.21 % of capacitance even over 10,000 cycles. The parameters presented here demonstrate a significant improvement compared to those typically observed in most modified wood-derived carbon-based supercapacitors, effectively addressing common issues of low energy density and suboptimal cycling performance with wood carbon composites., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

MXenes have attracted growing interest in electrochemical energy storage owing to their high electronic conductivity and editable surface chemistry. Besides, rendering MXenes with spectrum defense properties further broadens their versatile applications. However, the development of MXenes suffers from weak van der Waal interaction-driven self-restacking that leads to random alignment and inferior interface microenvironments. Herein, a nacre-inspired MXene film is tailored by dual-filling of 2-ureido-4[1H]-pyrimidinone (UPy)-modified polyvinyl alcohol (PVA-UPy) and carbon nanotubes (CNTs). The dual-nanofillers engineering endows the nanocomposite film with a highly ordered structure (a Herman's order value of 0.838), a high mechanical strength (139.5 MPa), and continuous conductive pathways of both the ab plane and c-axis. As a proof-of-concept, the tailored nanocomposite film achieves a considerable capacitance of 508.2 F cm -3 and long-term cycling stability without performance degradation for 10 000 cycles. It is efficient for spectra defense in radar and infrared bands, displaying a high electromagnetic shielding capacity (19186 dB cm 2 g -1 ) and a super-low infrared (IR) emissivity (0.16), with negligible performance decay after saving in the air for 1 year, responsible for the applications in specific and complex conditions. This interfacial dual-filler engineering concept showcases effective nanotechnology toward sustainable energy applications with a long lifetime and safety., (© 2024 Wiley‐VCH GmbH.)

Graphene nanoribbon is a novel variety of graphene with high length-to-width ratio and straight edges. Herein, we report an improved method for the synthesis of graphene oxide nanoribbons (GONRs) from longitudinal unraveling of multiwalled carbon nanotubes by means of a one-step, one-pot pressurized oxidation reaction. The obtained GONRs were characterized by different techniques. Furthermore, owing to their unique properties such as strong optical absorption and good water dispersibility, we show that GONRs can be used as an excellent matrix or probe in matrix-assisted or surface-enhanced laser desorption/ionization mass spectrometry (MALDI or SELDI MS) for the first time. In MALDI MS, GONRs generated significantly higher signals than conventional organic matrix and other graphene-based matrices in the detection of low-mass compounds. We also demonstrate the use of GONRs as a sensitive SELDI probe for simultaneous detection of multiple small molecules and profiling of small molecules in complex environmental samples, thus revealing its application potential in rapid screening of low-mass pollutants in complex media., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)