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8 results on '"Chloe Miller"'

1. Insights into the spatial ecology of the world’s most ancient dog: High-altitude movements of New Guinea dingoes

Author

Benjamin L. Allen, Chloe Miller, Lisa Wolf, Hendra K. Maury, Leonardo A. Numberi, Suriani Surbakti, Berna Natalia Br Silaban, Kukuh Indra Kusuma, and James K. McIntyre

Subjects
Activity patterns, Ancient dog, Canis hallstromi, Movement ecology, New Guinea highland wild dog, New Guinea singing dog, Ecology, QH540-549.5
Abstract

Knowledge of an animal’s activity patterns, home range size and space use is fundamental to understanding their basic ecology, and obtaining spatial data is an important research priority for newly discovered species, data-deficient species of conservation concern, or species of great scientific or public interest. Here we report the first spatial data obtained from wild-living dingoes near Puncak Jaya, New Guinea. Based on information from four dingoes monitored with GPS tracking collars between 2018 and 2022, we report that dingo home range sizes can be up to 128 km2, dingoes travel up to 56.8 km per day, and they utilise rainforest and alpine habitats up to 4630 m above sea level. Dingoes at the site regularly traversed steep, rocky and barren alpine mountain crevasses to access more fertile areas at lower altitudes on the other side. These results imply that New Guinea dingoes may have physiological and genetic adaptations that enable them to live in high-altitude low-oxygen environments similar to Himalayan wolves, Ethiopian wolves, and other canids found in high-altitude areas. As the first domesticated animal and the world’s most ancient dog, and given their historic and current cultural significance, their illusiveness in the wild, and their trophic position as the largest terrestrial predators on the second-largest island in the world, we believe that further research on the ecology of New Guinea dingoes will continue to reveal important insights valuable for our understanding of human and animal ecology in this global biodiversity hotspot.

Published
2024
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2. Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes

Author

Susmita Bhattarai, Utsab Subedi, Shrivats Manikandan, Sudha Sharma, Papori Sharma, Chloe Miller, Md Shenuarin Bhuiyan, Srivatsan Kidambi, Vassilis Aidinis, Hong Sun, Sumitra Miriyala, and Manikandan Panchatcharam

Subjects
autotaxin (ATX), lysophosphatidic acid (LPA), ischemic stroke, endothelium, permeability, Cytology, QH573-671
Abstract

Autotaxin (ATX) is an extracellular secretory enzyme (lysophospholipase D) that catalyzes the hydrolysis of lysophosphatidyl choline to lysophosphatidic acid (LPA). The ATX–LPA axis is a well-known pathological mediator of liver fibrosis, metastasis in cancer, pulmonary fibrosis, atherosclerosis, and neurodegenerative diseases. Additionally, it is believed that LPA may cause vascular permeability. In ischemic stroke, vascular permeability leading to hemorrhagic transformation is a major limitation for therapies and an obstacle to stroke management. Therefore, in this study, we generated an endothelial-specific ATX deletion in mice (ERT2 ATX−/−) to observe stroke outcomes in a mouse stroke model to analyze the role of endothelial ATX. The AR2 probe and Evans Blue staining were used to perform the ATX activity and vascular permeability assays, respectively. Laser speckle imaging was used to observe the cerebral blood flow following stroke. In this study, we observed that stroke outcomes were alleviated with the endothelial deletion of ATX. Permeability and infarct volume were reduced in ERT2 ATX−/− mice compared to ischemia–reperfusion (I/R)-only mice. In addition, the cerebral blood flow was retained in ERT2 ATX−/− compared to I/R mice. The outcomes in the stroke model are alleviated due to the limited LPA concentration, reduced ATX concentration, and ATX activity in ERT2 ATX−/− mice. This study suggests that endothelial-specific ATX leads to increased LPA in the brain vasculature following ischemic–reperfusion and ultimately disrupts vascular permeability, resulting in adverse stroke outcomes.

Published
2023
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3. Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated Signaling and Mitochondrial Dysfunction

Author

Sudha Sharma, Papori Sharma, Tara Bailey, Susmita Bhattarai, Utsab Subedi, Chloe Miller, Hosne Ara, Srivatsan Kidambi, Hong Sun, Manikandan Panchatcharam, and Sumitra Miriyala

Subjects
oxidative stress, lipid peroxidation, 4-hydroxynonenal, mitochondrial dysfunction, Microbiology, QR1-502
Abstract

Reactive oxygen species (ROS), a by-product of aerobic life, are highly reactive molecules with unpaired electrons. The excess of ROS leads to oxidative stress, instigating the peroxidation of polyunsaturated fatty acids (PUFA) in the lipid membrane through a free radical chain reaction and the formation of the most bioactive aldehyde, known as 4-hydroxynonenal (4-HNE). 4-HNE functions as a signaling molecule and toxic product and acts mainly by forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and lipids. The mitochondria have been implicated as a site for 4-HNE generation and adduction. Several studies clarified how 4-HNE affects the mitochondria’s functions, including bioenergetics, calcium homeostasis, and mitochondrial dynamics. Our research group has shown that 4-HNE activates mitochondria apoptosis-inducing factor (AIFM2) translocation and facilitates apoptosis in mice and human heart tissue during anti-cancer treatment. Recently, we demonstrated that a deficiency of SOD2 in the conditional-specific cardiac knockout mouse increases ROS, and subsequent production of 4-HNE inside mitochondria leads to the adduction of several mitochondrial respiratory chain complex proteins. Moreover, we highlighted the physiological functions of HNE and discussed their relevance in human pathophysiology and current discoveries concerning 4-HNE effects on mitochondria.

Published
2022
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4. Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study

Author

Douglas L Fink, Helen Callaby, Akish Luintel, William Beynon, Helena Bond, Eleanor Y Lim, Effrossyni Gkrania-Klotsas, Jospeh Heskin, Margherita Bracchi, Balram Rathish, Iain Milligan, Geraldine O'Hara, Stephanie Rimmer, Joanna R Peters, Lara Payne, Nisha Mody, Bethany Hodgson, Penny Lewthwaite, Rebecca Lester, Stephen D Woolley, Ann Sturdy, Ashley Whittington, Leann Johnson, Nathan Jacobs, John Quartey, Brendan AI Payne, Stewart Crowe, Ivo AM Elliott, Thomas Harrison, Joby Cole, Katie Beard, Tomas-Paul Cusack, Imogen Jones, Rishi Banerjee, Tommy Rampling, Jake Dunning, Iain D Milligan, Alison J Rodger, Sanjay R Bhagani, Lucy E Lamb, Rachel C Moores, Simon F K Lee, Colin S Brown, Susan Hopkins, Stephen Mepham, Simon Warren, Aoife Molloy, Ian Cropley, Alex Kew, Natasha Karunaharan, Antonia Scobie, Jennifer Hart, Dianne Irish, Tanzina Haque, Hamid Jalal, Robin Smith, Damien Mack, Tristan Barber, Fiona Burns, Robert Miller, Eleanor Hamlyn, Pedro Simoes, Breda Athan, Jennifer Abrahamsen, Jessica Joyce, Caroline Taylor, Sally Reddecliffe, Chloe Miller, Brooke Reeve, Hugh Kingston, Tim Crocker-Buque, Nicolas Massie, Ankush Dhariwal, Angelina Jayakumar, Robert Hammond, Alexandra Bramley, Tanmay Kanitkar, Laura Maynard-Smith, Eliza Gil, Cavan O'Connor, Derek Cocker, Wendy Spicer, Marisa Lanzman, Meera Thacker, Zoe O Anorson, Dharmesh Patel, Alan Williams, Catherine F Houlihan, Dominic Wakerley, Claire N Gordon, Daniel J Bailey, Jenna Furneaux, Abbie M Bown, Elizabeth J Truelove, Marian J Killip, David Jackson, Tracy L B Beetar-King, Ulrike M V Arnold, Rhea M Strachan, Jones Matthew, Hannah J Matthew, Jane C Osborne, Richard Vipond, Barry Gibney, Jodie Owen, Will Beynon, Michael Hunter, Louise McCorry, Carol Emerson, Say Quah, Suzanne Todd, Emma McCarty, Eoin Walker, Susan Feeney, Tanya Curran, Kathy Li, JD Mullan, Kate Jackson, Peter Nelson, Kevin Lewis, Mark McNicol, Marcus Pratt, Anna Smith, Erin Vos, Fahad Alsalemee, Daniel O Leary, John Canny, Katherine McGinnity, Carly Culbert, Conor McDowell, Cathy McQuillan, Eunjin Jeong, Lynsey Glass, Jessica Dyche, Paula McClean, Rebecca Stewart, Harold Ursolino, Melissa Perry, Hannah McCormick, Joseph Heskin, Nicklas Brown, Thomas Juniper, Borja Mora-Peris, Alessia Dalla-Pria, Nicola Mackie, Lucy Garvey, Alan Winston, Graham Cooke, Mark Nelson, Emer Kilbride, Ala Elbishi, William Kerrigan, Joshua Silva, Jesal Gohil, Sasha Payagala, Yasmin Walters, Joanna Smith, Jonathan Goodfellow, Kitty Lyons, Hsiu Tung, Kinjal Patel, Merle Henderson, Michael Butler, Edu Peres, Taiana Silva Carvalho, Antoine Joly, Molly Dickinson, Luke S P Moore, Nabeela Mughal, Stephen Hughes, Shrada Chitlangia, Priyanka Viramgana, Ruth Byrne, Paul Randell, Luigi Strangis, Nicola Poveda, Deborah Bovey, Poppy Richardson, Vivian Heaslip, Christopher Higgs, Marta Boffito, Nicolo Girometti, Gary Whitlock, Victoria Tittle, Rachel Jones, Michael Rayment, Christopher Scott, David Asboe, Marcus Pond, David Muir, Movin Abeywickrema, Sarah-Lou Bailey, Sara E Boyd, Dayana Da Silva Fontoura, Anna Daunt, Claire Y Mason, Jamie Murphy, Vasanth V Naidu, Aatish Patel, Caitlin Pley, Ethan Redmore, Katherine Sharrocks, Luke B Snell, Rohan Sundramoorthi, Jerry C H Tam, Aisling Brown, Sam Douthwaite, Anna Goodman, Gaia Nebbia, William Newsholme, Nicholas Price, Emily Shaw, Alex Salam, Claire van Nispen tot Pannerden, Helen Winslow, Julia Bilinska, Sarah Keegan, Harry Coleman, Jessica Doctor, Nasreen Moini, Daniella Chilton, Golaleh Haidari, Rebecca Simons, Rajababu Kulasegaram, Nick Larbalestier, Achyuta Nori, Jack R Potter, Cecilia Tuudah, Paul Wade, Alexandra Travers, Sarah Dunford, Joshua Greenwood, Georgina Oledimmah, Lesley Gyampo, Pedro SA Pinto, AbdulKadir Muse, Zoe Parker, Charlotte Alexander, Alexander Khan, Medinat Ajayi, Abigail Baltazar, Davis Sharella, Nasra Hersi, Thuy Nguyen, Rugiatu Timbo, Ismail Jalloh, Susan Bryan, Patricia Clarke, Marcia Kerr, Fidelis Amedu, Maria BohoBonaba, Sarah Haque, Michelle Howson, Norbai Tambilawan, Soledad Yupanqui Estay, Hawanatu Bangura, Tseday Gideon, Damilola Jerome-oboh, Linda Tetteh, Chioma Nwagu, Viwoalo Agbaglah, Nona Narag, Mahima Zaveri, Maedhbh Ni Luanaigh, Peggy Keane, Aula Abbara, Olamide Dosekun, Mhairi Bolland, Adam Stafford, Dina Saleh, Rhianna Sheridan, Ella Davies, Kristi Sun, Mark Gilchrist, Priti Kukadia, Muhammed Embrahimsa, Christopher Chiu, Lauren Taylor, Charlotte Short, Jasmini Alagratnam, Iresh Jayaweera, Kavitha Gundugola, Lara V S Payne, Killian Quinn, Caoimhe Nic Fhogartaigh, Nivenjit Kaur, Salmaan Bholah, Kajann Kantha, Jonathan Youngs, Temi Lampejo, Nicholas Pitto, David S Lawrence, Holly Middleditch, Lourdes Dominguez-Dominguez, Ayoma Ratnappuli, Sara Al-Hashimi, Amelia Oliveira, Zoe Ottaway, Larissa Mulka, Anne M Neary, Michael R Downey, Danielle C Lucy, Craig I McCallum, Michael Beadsworth, Libuse Ratcliffe, Tom E Fletcher, Gerry Davies, Nicholas Wong, Stephen Aston, Thomas E Wingfield, Thomas Blanchard, Paul Hine, Susie Gould, Christopher Smith, Michael Abouyannis, Abolaji Atomode, James Cruise, Merna Samual, Nicola Scott, Vino Srirathan, Joseph Lewis, Lauren Richards, Mary-Ann Cummings, Emily Gillan, Rebecca Peers, Amy Tickle, Grace Keating, Tendi Chinyanda, Mav Sanchez, Daniel Harrison, null Hoyle, Ben Metcalfe, Jennifer Taylor, Nicky Johnson, Neil Kelle, Kirsty McDowell, Ian Richardson, Monette Saguidan, Nicky Farmer, Angella Gillespie, Shay Willoughby, Samantha Parker, Shamseena Avulan, Shazia Arif, Suzanne Marshall, David Carlisle, Mohsen Rezaei, Angela Booth, Joanne Watts, Lauren Tremarco, Priyanga Jeyanayagam, Odinaka Ubochi, Daniel Vagianos, Mark Richardson, Anthony Jarvis, Kyra Gow, Jade Walmsley, Adam O'keefe, Anna Smielewska, Mark Hopkins, Fatima Balane, Sarah Bradley, Tumena Corrah, Venus Daquiz, Christopher Dugan, Joshua Elliot, Fiona Foley, Dawn Friday, May Gamit, David Garner, Karishma Gokani, Laurence John, Deepa Joseph, Nuzhath Khan, Cherifer Mamuyac, Alastair McGregor, John McSorley, Victoria Parris, Luciana Rubinstein, Julian Rycroft, Kelcy Salinas, Jason Salinas, Jency Sebatian, Melanie Smith, Marina Tejero Garcia, Uchenna Ume, Margarete Vicentine, Gabriel Wallis, Alec Bonington, Alison Uriel, Andrew Ustianowski, Balazs Dancso, Celia Hogan, Clare van Halsema, F Javier Vilar, Karen Devine, Katherine Ajdukiewicz, Rajesh Rajendran, Samit Ghosh, Michael Riste, Nicholas Machin, Chitra Babu, Shazaad Ahmad, Dorcas Obeng, Farnaz Dave, Gavin Conolley, Joseph Thompson, Maya Tickell-Painter, Prasun Chakravorty, Rachel Pringle, Mohammad R Zafar, Sarah Lawrence, Amada Sanchez-Gonzalez, Cristina Fernandez, Lynsey Goodwin, David Carey, Molly Howarth-Maddison, Samuel Moody, Rebecca Upton, Christina Apthorp, Charlotte Murray, Kirstie Salthouse, Sabah Nadeem, Grant Ridley, Francesca White, Andrew Brown, Michael Lawless, Mohamed Mohamed, Robert Mulligan, Amy Belfield, Jacob Brolly, Maria Calderon, James Cheveau, Milo Cullinan, Sophie Garrad, Will Griffiths, Aidan Ireland, Peter Ireland, Charlotte Milne, Paul Nwajiugo, Bijan Ghavami-Kia, Chris Duncan, Adam Evans, Ewan Hunter, Ashley Price, Matthias Schmid, Uli Schwab, Yusri Taha, Brendan Payne, Ivo A M Elliott, Charles J Woodrow, Drosos E Karageorgopoulos, Peter J Davis, Emily Lord, Oliver J Bannister, Andrew B Dagens, Anne Tunbridge, Saher Choudry, Adam Telfer, Ihsan Jhibril, Syed N Atta, Ben Stone, Cariad Evans, Mike Ankcorn, Suha Akili, Mehmet Yavuz, Vicky Goodall, Sam Farrow, Georgina Mountford, Kate Beard, Julian Sutton, Tristan Clark, Annette Mason, Mike Vickers, Derek Macallan, Tihana Bicanic, Angela Houston, Cassie Pope, NgeeKeong Tan, Christopher Ward, Jonathan Cohen, Marieke Emonts-le Clercq, David Porter, Andrew Riordan, Ruchi Sinha, Elizabeth Whittaker, and Monkeypox, Specialist and High Consequence Infectious Diseases Centres Network for

Subjects
Infectious Diseases
Abstract

Background:The scale of the 2022 global mpox (formerly known as monkeypox) outbreak has been unprecedented. In less than 6 months, non-endemic countries have reported more than 67 000 cases of a disease that had previously been rare outside of Africa. Mortality has been reported as rare but hospital admission has been relatively common. We aimed to describe the clinical and laboratory characteristics and outcomes of individuals admitted to hospital with mpox and associated complications, including tecovirimat recipients. Methods:In this cohort study, we undertook retrospective review of electronic clinical records and pathology data for all individuals admitted between May 6, and Aug 3, 2022, to 16 hospitals from the Specialist and High Consequence Infectious Diseases Network for Monkeypox. The hospitals were located in ten cities in England and Northern Ireland. Inclusion criteria were clinical signs consistent with mpox and MPXV DNA detected from at least one clinical sample by PCR testing. Patients admitted solely for isolation purposes were excluded from the study. Key outcomes included admission indication, complications (including pain, secondary infection, and mortality) and use of antibiotic and anti-viral treatments. Routine biochemistry, haematology, microbiology, and virology data were also collected. Outcomes were assessed in all patients with available data. Findings:156 individuals were admitted to hospital with complicated mpox during the study period. 153 (98%) were male and three (2%) were female, with a median age of 35 years (IQR 30–44). Gender data were collected from electronic patient records, which encompassed full formal review of clincian notes. The prespecified options for data collection for gender were male, female, trans, non-binary, or unknown. 105 (71%) of 148 participants with available ethnicity data were of White ethnicity and 47 (30%) of 155 were living with HIV with a median CD4 count of 510 cells per mm3(IQR 349–828). Rectal or perianal pain (including proctitis) was the most common indication for hospital admission (44 [28%] of 156). Severe pain was reported in 89 (57%) of 156, and secondary bacterial infection in 82 (58%) of 142 individuals with available data. Median admission duration was 5 days (IQR 2–9). Ten individuals required surgery and two cases of encephalitis were reported. 38 (24%) of the 156 individuals received tecovirimat with early cessation in four cases (two owing to hepatic transaminitis, one to rapid treatment response, and one to patient choice). No deaths occurred during the study period. Interpretation:Although life-threatening mpox appears rare in hospitalised populations during the current outbreak, severe mpox and associated complications can occur in immunocompetent individuals. Analgesia and management of superimposed bacterial infection are priorities for patients admitted to hospital.

Published
2023
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5. Mn(III) Porphyrin, MnTnBuOE-2-PyP5+, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress

Author

Sudha Sharma, Papori Sharma, Utsab Subedi, Susmita Bhattarai, Chloe Miller, Shrivats Manikandan, Ines Batinic-Haberle, Ivan Spasojevic, Hong Sun, Manikandan Panchatcharam, and Sumitra Miriyala

Subjects
Inorganic Chemistry, Organic Chemistry, General Medicine, superoxide, cardiomyocytes, SOD2, apoptosis, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Catalysis, Computer Science Applications
Abstract

Myocardial ischemia-reperfusion injury (I/R) causes damage to cardiomyocytes through oxidative stress and apoptosis. We investigated the cardioprotective effects of MnTnBuOE-2-PyP5+ (BMX-001), a superoxide dismutase mimic, in an in vitro model of I/R injury in H9c2 cardiomyocytes. We found that BMX-001 protected against hypoxia/reoxygenation (H/R)-induced oxidative stress, as evident by a significant reduction in intracellular and mitochondrial superoxide levels. BMX-001 pre-treatment also reduced H/R-induced cardiomyocyte apoptosis, as marked by a reduction in TUNEL-positive cells. We further demonstrated that BMX-001 pre-treatment significantly improved mitochondrial function, particularly O2 consumption, in mouse adult cardiomyocytes subjected to H/R. BMX-001 treatment also attenuated cardiolipin peroxidation, 4-hydroxynonenal (4-HNE) level, and 4-HNE adducted proteins following H/R injury. Finally, the pre-treatment with BMX-001 improved cell viability and lactate dehydrogenase (LDH) activity in H9c2 cells following H/R injury. Our findings suggest that BMX-001 has therapeutic potential as a cardioprotective agent against oxidative stress-induced H/R damage in H9c2 cardiomyocytes.

Published
2023
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8. Understanding renal patients who are challenging or complex

Author

Chloe Miller, Amy Stevenson, and Janette Moran

Subjects
03 medical and health sciences, 0302 clinical medicine, Psychotherapist, biology, 05 social sciences, Attachment theory, Miller, 050109 social psychology, 0501 psychology and cognitive sciences, 030212 general & internal medicine, biology.organism_classification, Psychology
Abstract

Patients receiving haemodialysis can sometimes present with behaviour which can be seen as ‘challenging’ to those offering care services. In this paper, Chloe Miller, Janette Moran and Amy Stevenson describe an attachment theory-based workshop aimed at helping staff in a haemodialysis unit understand why some patients react the way they do.

Published
2017
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