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Your search keyword '"Chu, Hsuan-Te"' showing total 31 results
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31 results on '"Chu, Hsuan-Te"'

11. Incongruent Expression of Brain-Derived Neurotrophic Factor and Cortisol in Schizophrenia: Results from a Randomized Controlled Trial of Laughter Intervention

Author

Cheng, Shu-Li, Yang, Fu-Chi, Chu, Hsuan-Te, Tsai, Chia-Kuang, Ku, Shih-Chieh, Tseng, Yu-Ting, Yeh, Ta-Chuan, and Liang, Chih-Sung

Subjects
medicine.medical_specialty, media_common.quotation_subject, Brain-derived neurotrophic factor, Cortisol, law.invention, Laughter, Randomized controlled trial, law, Neurotrophic factors, Intervention (counseling), Internal medicine, medicine, Biological Psychiatry, media_common, Laughter therapy, business.industry, Laughter Therapy, medicine.disease, Complementary therapies, Discontinuation, Psychiatry and Mental health, Schizophrenia, Original Article, business
Abstract

Objective Schizophrenia has been associated with dysfunction of the hypothalamic-pituitary-adrenal axis. Furthermore, alterations in neurotrophic factors might contribute to the pathogenesis of schizophrenia. We aimed to evaluate the effects of a simulated laughter intervention on the levels of cortisol and BDNF and to determine whether the effects associated with simulated laughter could be sustained after discontinuation of the intervention. Methods In this randomized controlled study, patients with schizophrenia according to DSM-IV clinical criteria were randomly assigned to receive either 8-week-long simulated laughter intervention (n=32) or treatment-as-usual group (control group, n=27). The serum levels of BDNF and cortisol were measured at baseline, week 8, and four weeks after discontinuation (week 12) of the intervention program.Results After an 8-week simulated laughter intervention, the laughter group had significantly higher levels of BDNF; however, four weeks after discontinuation of the intervention, the levels of BDNF significantly dropped. Interestingly, the levels of cortisol did not change significantly at week 8, but they were significantly elevated at week 12. The levels of BDNF and cortisol in the control group did not change significantly between week 0 and week 8.Conclusion These findings suggest that the simulated laughter intervention has an early effect on neurogenesis with a significant delayed effect on stress regulation in subjects with schizophrenia.

Published
2020
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12. Early Antidepressant Resistance in Late-Onset Major Depressive Disorder

Author

Lin, Po-Chun, primary, Yeh, Ta-Chuan, additional, Bai, Ya-Mei, additional, Hsu, Ju-Wei, additional, Huang, Kai-Lin, additional, Ko, Nai-Ying, additional, Chu, Che-Sheng, additional, Chu, Hsuan-Te, additional, Tsai, Shih-Jen, additional, Chen, Tzeng-Ji, additional, Liang, Chih-Sung, additional, and Chen, Mu-Hong, additional

Published
2022
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16. Better Identification of Cognitive Decline With Interleukin-2 Than With Amyloid and Tau Protein Biomarkers in Amnestic Mild Cognitive Impairment

Author

Liang, Chih-Sung, primary, Tsai, Chia-Lin, additional, Lin, Guan-Yu, additional, Lee, Jiunn-Tay, additional, Lin, Yu-Kai, additional, Chu, Che-Sheng, additional, Sung, Yueh-Feng, additional, Tsai, Chia-Kuang, additional, Yeh, Ta-Chuan, additional, Chu, Hsuan-Te, additional, Su, Ming-Wei, additional, and Yang, Fu-Chi, additional

Published
2021
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25. Associations Between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study

Author

Tsai, Chia-Lin, primary, Liang, Chih-Sung, additional, Lee, Jiunn-Tay, additional, Su, Ming-Wei, additional, Lin, Chun-Chieh, additional, Chu, Hsuan-Te, additional, Tsai, Chia-Kuang, additional, Lin, Guan-Yu, additional, Lin, Yu-Kai, additional, and Yang, Fu-Chi, additional

Published
2019
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30. Associations between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study.

Author

Tsai, Chia-Lin, Liang, Chih-Sung, Lee, Jiunn-Tay, Su, Ming-Wei, Lin, Chun-Chieh, Chu, Hsuan-Te, Tsai, Chia-Kuang, Lin, Guan-Yu, Lin, Yu-Kai, and Yang, Fu-Chi

Subjects
AMNESTIC mild cognitive impairment, ALZHEIMER'S patients, LONGITUDINAL method, COGNITION disorders, TAU proteins
Abstract

Brain degeneration in patients with Alzheimer's disease (AD) results from the accumulation of pathological amyloid-β (Aβ) plaques and tau protein tangles, leading to altered plasma levels of biomarkers. However, few studies have investigated the association between plasma biomarkers and cognitive impairment in patients with AD. In this cross-sectional study, we investigated correlations between mini-mental state examination (MMSE) scores and levels of plasma biomarkers in patients with amnestic mild cognitive impairment (aMCI) and AD. Thirteen individuals with normal cognition, 40 patients with aMCI, and 37 patients with AD were enrolled. Immunomagnetic reduction was used to assess the levels of plasma biomarkers, including amyloid Aβ1-40, Aβ1-42, total tau protein (t-Tau), and phosphorylated tau protein (threonine 181, p-Tau181). Our analysis revealed a significant negative correlation between MMSE and both measures of tau, and a trend toward negative correlation between MMSE and Aβ1-42. In a longitudinal study involving three patients with aMCI and two patients with AD, we observed strong negative correlations (r < −0.8) between changes in MMSE scores and plasma levels of t-Tau. Our results suggest that plasma levels of t-Tau and p-Tau181 can be used to assess the severity of cognitive impairment in patients with AD. Furthermore, the results of our preliminary longitudinal study suggest that levels of t-Tau can be used to monitor the progression of cognitive decline in patients with aMCI/AD. [ABSTRACT FROM AUTHOR]

Published
2019
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31. Efficacy of pregabalin augmentation for refractory pain in late-life depression.

Author

Chu HT, Chen CK, Tzeng NS, Chen YC, and Yeh TC

Subjects
Aged, Duloxetine Hydrochloride therapeutic use, Female, Humans, Psychiatric Status Rating Scales, Tramadol therapeutic use, Treatment Outcome, Calcium Channel Blockers administration & dosage, Depressive Disorder drug therapy, Pain, Intractable drug therapy, Pregabalin administration & dosage
Published
2017
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