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Your search keyword '"Chu, Wen-Feng"' showing total 15 results
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15 results on '"Chu, Wen-Feng"'

6. [Electroacupuncture improves cognitive function by inhibiting NF-κB activity in rats with chronic fatigue syndrome]

Author

Chu-Wen, Feng, Yuan-Yuan, Qu, Zhong-Ren, Sun, Yu-Lin, Wang, Peng, Zhang, Qing-Yong, Wang, Wan-Juan, Lin, Lin, Zhang, and Tian-Song, Yang

Subjects
Rats, Sprague-Dawley, Cognition, Electroacupuncture, Fatigue Syndrome, Chronic, Alzheimer Disease, NF-kappa B, Animals, Hippocampus, Rats
Abstract

To observe the effect of electroacupuncture (EA) on the expression of NF-κB p65 in hippocampus and the morphology of hippocampus in rats with chronic fatigue syndrome (CFS), so as to explore its mechanism in improving cognitive dysfunction of CFS.Forty-eight SD rats were randomly divided into control, model, EA and inhibitor groups (After mode-ling, the general status score was increased （EA can improve the cognitive function in CFS rats, which may be associated with its effect in inhibiting the expression of NF-κB and reducing the inflammation response in hippocampus.

Published
2021

7. [Analgesic mechanism of acupuncture on neuropathic pain]

Author

Qing-Yong, Wang, Yuan-Yuan, Qu, Chu-Wen, Feng, Wei-Bo, Sun, De-Long, Wang, Tian-Song, Yang, and Zhong-Ren, Sun

Subjects
Analgesics, Acupuncture Therapy, Acupuncture, Humans, Neuralgia, Acupuncture Analgesia
Abstract

The research progress of acupuncture analgesia in recent years is analyzed to summarize the analgesic mechanism of acupuncture on neuropathic pain. The analgesic mechanism of acupuncture on neuropathic pain is discussed from peripheral level and central level, including peripheral sensitization and immune inflammatory response, changes of ion channel, central sensitization, regulation of cell signal pathway, activation of spinal glial cells, etc. It is suggested that the focus of future research should include conducting in-vitro studies with the help of multi-omics technology to detect the changes of metabolic substances and signal pathway molecules in patients with neuropathic pain before and after acupuncture to further clarify the mechanism of acupuncture analgesia.

Published
2020

10. PMLIV overexpression promotes TGF‐β‐associated epithelial–mesenchymal transition and migration in MCF‐7 cancer cells

Author

Liu, Yu, primary, Wang, Jia‐Xin, additional, Huang, Di, additional, Wang, Bing, additional, Li, Liang‐Liang, additional, Li, Xiu‐Xian, additional, Ni, Ping, additional, Dong, Xing‐Li, additional, Xia, Wei, additional, Yu, Chun‐Xiao, additional, Xu, Wan‐Lu, additional, Chu, Wen‐Feng, additional, and Zhao, Dan, additional

Published
2018
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12. Transforming Growth Factor‐β Receptor III is a Potential Regulator of Ischemia‐Induced Cardiomyocyte Apoptosis

Author

Sun, Fei, primary, Li, Xin, additional, Duan, Wen‐Qi, additional, Tian, Wei, additional, Gao, Ming, additional, Yang, Jia, additional, Wu, Xia‐Yang, additional, Huang, Di, additional, Xia, Wei, additional, Han, Yan‐Na, additional, Wang, Jia‐Xin, additional, Liu, Yan‐Xin, additional, Dong, Chang‐Jiang, additional, Zhao, Dan, additional, Ban, Tao, additional, and Chu, Wen‐Feng, additional

Published
2017
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13. Arsenic trioxide and angiotensin II have inhibitory effects on HERG protein expression: Evidence for the role of PML SUMOylation

Author

Liu, Yu, primary, Li, Duo, additional, Nie, Dan, additional, Liu, Shang-Kun, additional, Qiu, Fang, additional, Liu, Mei-Tong, additional, Li, Yuan-Yuan, additional, Wang, Jia-Xin, additional, Liu, Yan-Xin, additional, Dong, Chang-Jiang, additional, Wu, Di, additional, Tian, Wei, additional, Yang, Jia, additional, Mu, Wei, additional, Li, Jia-Tong, additional, Zhao, Dan, additional, Wang, Xiao-Feng, additional, Chu, Wen-Feng, additional, and Yang, Bao-Feng, additional

Published
2017
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14. TGF‐β1‐PML SUMOylation‐peptidyl‐prolyl cis–trans isomerase NIMA‐interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis.

Author

Wu, Di, Huang, Di, Li, Liang‐Liang, Ni, Ping, Li, Xiu‐Xian, Wang, Bing, Han, Yan‐Na, Shao, Xiao‐Qi, Zhao, Dan, Chu, Wen‐Feng, and Li, Bai‐Yan

Subjects
TRANSFORMING growth factors, HEART fibrosis, COLLAGEN, FIBROBLASTS, DOWNREGULATION, MESSENGER RNA
Abstract

Transforming growth factor‐β (TGF‐β) signaling pathway is involved in fibrosis in most, if not all forms of cardiac diseases. Here, we evaluate a positive feedback signaling the loop of TGF‐β1/promyelocytic leukemia (PML) SUMOylation/Pin1 promoting the cardiac fibrosis. To test this hypothesis, the mice underwent transverse aortic constriction (3 weeks) were developed and the morphological evidence showed obvious interstitial fibrosis with TGF‐β1, Pin1 upregulation, and increase in PML SUMOylation. In neonatal mouse cardiac fibroblasts (NMCFs), we found that exogenous TGF‐β1 induced the upregulation of TGF‐β1 itself in a time‐ and dose‐dependent manner, and also triggered the PML SUMOylation and the formation of PML nuclear bodies (PML‐NBs), and consequently recruited Pin1 into nuclear to colocalize with PML. Pharmacological inhibition of TGF‐β signal or Pin1 with LY364947 (3 μM) or Juglone (3 μM), the TGF‐β1‐induced PML SUMOylation was reduced significantly with downregulation of the messenger RNA and protein for TGF‐β1 and Pin1. To verify the cellular function of PML by means of gain‐ or loss‐of‐function, the positive feedback signaling loop was enhanced or declined, meanwhile, TGF‐β‐Smad signaling pathway was activated or weakened, respectively. In summary, we uncovered a novel reciprocal loop of TGF‐β1/PML SUMOylation/Pin1 leading to myocardial fibrosis. Exogenous transforming growth factor‐β (TGF‐β1) is added into neonatal mouse cardiac fibroblasts, triggering promyelocytic leukemia (PML) SUMOylation and PML nuclear bodies (NBs) formation. Meanwhile, Pin1 is recruited into the PML‐NBs and colocated in the nuclear body. Then, the messenger RNA level and protein level of TGF‐β1 are both increased, activating the TGF‐β/Smad‐2/3 signaling pathway, increasing collagen formation, and ultimately leading to cardiac fibrosis. [ABSTRACT FROM AUTHOR]

Published
2019
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