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7 results on '"Cimpean, Anca M."'

1. Consensus guidelines for the use and interpretation of angiogenesis assays

Author

Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C, Auerbach, Robert, Augustin, Hellmut G, Bates, David O, van Beijnum, Judy R, Bender, R Hugh F, Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Böck, Barbara C, Brooks, Peter C, Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M, Cleaver, Ondine, Coukos, George, Davis, George E, De Palma, Michele, Dimberg, Anna, Dings, Ruud PM, Djonov, Valentin, Dudley, Andrew C, Dufton, Neil P, Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquière, Bart, Gong, Yan, Griffin, Robert J, Harris, Adrian L, Hughes, Christopher CW, Hultgren, Nan W, Iruela-Arispe, M Luisa, Irving, Melita, Jain, Rakesh K, Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S, Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K, Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R, Marien, Koen, Melero-Martin, Juan M, Munn, Lance L, Nicosia, Roberto F, Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V, Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W, Post, Mark J, Quax, Paul HA, Rabinovich, Gabriel A, Raica, Marius, Randi, Anna M, Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O, Schulte-Merker, Stefan, Smith, Lois EH, Song, Jonathan W, Stacker, Steven A, Stalin, Jimmy, Stratman, Amber N, Van de Velde, Maureen, van Hinsbergh, Victor WM, Vermeulen, Peter B, Waltenberger, Johannes, Weinstein, Brant M, Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C, and Griffioen, Arjan W

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cardiovascular, Animals, Biological Assay, Guidelines as Topic, Humans, Mice, Neoplasms, Neovascularization, Pathologic, Angiogenesis, Aortic ring, Endothelial cell migration, Proliferation, Microfluidic, Zebrafish, Chorioallantoic membrane, Vascular network, Intussusceptive angiogenesis, Retinal vasculature, Corneal angiogenesis, Hindlimb ischemia, Myocardial angiogenesis, Recombinant proteins, Tip cells, Plug assay, Vessel co-option, Clinical Sciences, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology
Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018

3. Targeting Tumor Vascular CD99 Inhibits Tumor Growth

Author

Huijbers, Elisabeth J. M., primary, van der Werf, Inge M., additional, Faber, Lisette D., additional, Sialino, Lena D., additional, van der Laan, Pia, additional, Holland, Hanna A., additional, Cimpean, Anca M., additional, Thijssen, Victor L. J. L., additional, van Beijnum, Judy R., additional, and Griffioen, Arjan W., additional

Published
2019
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4. Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth

Author

Thijssen, Victor LJL, Paulis, Yvette WJ, Nowak-Sliwinska, Patrycja, Deumelandt, Katrin L, Hosaka, Kayoko, Soetekouw, Patricia MMB, Cimpean, Anca M, Raica, Marius, Pauwels, Patrick, van den Oord, Joost J, Tjan-Heijnen, Vivianne CG, Hendrix, Mary J, Heldin, Carl-Henrik, Cao, Yihai, Griffioen, Arjan W, Promovendi ODB, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), Medical oncology laboratory, Radiation Oncology, VU University medical center, and CCA - Cancer biology and immunology

Subjects
Time Factors, perivascular cells, Cell Communication/drug effects, TO-MESENCHYMAL TRANSITION, Melanoma, Experimental, vessel stabilization, Cell Communication, STEM-LIKE CELLS, Cell Proliferation/drug effects, Mice, Antineoplastic Agents, Immunological, Signal Transduction/drug effects, Pathology, IN-VIVO, Platelet-Derived Growth Factor, ddc:615, CO-OPTION, Neovascularization, Pathologic, Biological Mimicry, Original Papers, endothelial cells, Antineoplastic Agents, Immunological/pharmacology, Tumor Burden, VASCULOGENIC MIMICRY, Oncology, PRIMARY CUTANEOUS MELANOMA, Imatinib Mesylate, Imatinib Mesylate/pharmacology, Life Sciences & Biomedicine, Tumor Burden/drug effects, Platelet-Derived Growth Factor/antagonists & inhibitors/immunology/metabolism, Signal Transduction, Mice, Nude, Cell Line, Tumor, melanoma, Animals, Humans, cancer, BREAST-CANCER, Protein Kinase Inhibitors, Cell Proliferation, Biological Mimicry/drug effects, Original Paper, Science & Technology, Melanoma, Experimental/blood supply/drug therapy/metabolism/pathology, tumor angiogenesis, Pericytes/drug effects/metabolism/pathology, Xenograft Model Antitumor Assays, ENDOTHELIAL-CELLS, Coculture Techniques, imatinib, Protein Kinase Inhibitors/pharmacology, METASTASIS, Human medicine, Pericytes, Ewing sarcoma, ANTI-ANGIOGENIC THERAPY
Abstract

Aggressive tumor cells can adopt an endothelial cell-like phenotype and contribute to the formation of a tumor vasculature, independent of tumor angiogenesis. This adoptive mechanism is referred to as vascular mimicry and it is associated with poor survival in cancer patients. To what extent tumor cells capable of vascular mimicry phenocopy the angiogenic cascade is still poorly explored. Here, we identify pericytes as important players in vascular mimicry. We found that pericytes are recruited by vascular mimicry-positive tumor cells in order to facilitate sprouting and to provide structural support of the vascular-like networks. The pericyte recruitment is mediated through platelet-derived growth factor (PDGF)-B. Consequently, preventing PDGF-B signaling by blocking the PDGF receptors with either the small tyrosine kinase inhibitor imatinib or blocking antibodies inhibits vascular mimicry and tumor growth. Collectively, the current study identifies an important role for pericytes in the formation of vascular-like structures by tumor cells. Moreover, the mechanism that controls the pericyte recruitment provides therapeutic opportunities for patients with aggressive vascular mimicry-positive cancer types. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ispartof: JOURNAL OF PATHOLOGY vol:246 issue:4 pages:447-458 ispartof: location:England status: published

Published
2018
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6. Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth

Author

Thijssen, Victor L. J. L., Paulis, Yvette W. J., Nowak-Sliwinska, Patrycja, Deumelandt, Katrin L., Hosaka, Kayoko, Soetekouw, Patricia M. M. B., Cimpean, Anca M., Raica, Marius, Pauwels, Patrick, van den Oord, Joost J., Tjan-Heijnen, Vivianne C. G., Hendrix, Mary J., Heldin, Carl-Henrik, Cao, Yihai, Griffioen, Arjan W., Thijssen, Victor L. J. L., Paulis, Yvette W. J., Nowak-Sliwinska, Patrycja, Deumelandt, Katrin L., Hosaka, Kayoko, Soetekouw, Patricia M. M. B., Cimpean, Anca M., Raica, Marius, Pauwels, Patrick, van den Oord, Joost J., Tjan-Heijnen, Vivianne C. G., Hendrix, Mary J., Heldin, Carl-Henrik, Cao, Yihai, and Griffioen, Arjan W.

Abstract

Aggressive tumor cells can adopt an endothelial cell-like phenotype and contribute to the formation of a tumor vasculature, independent of tumor angiogenesis. This adoptive mechanism is referred to as vascular mimicry and it is associated with poor survival in cancer patients. To what extent tumor cells capable of vascular mimicry phenocopy the angiogenic cascade is still poorly explored. Here, we identify pericytes as important players in vascular mimicry. We found that pericytes are recruited by vascular mimicry-positive tumor cells in order to facilitate sprouting and to provide structural support of the vascular-like networks. The pericyte recruitment is mediated through platelet-derived growth factor (PDGF)-B. Consequently, preventing PDGF-B signaling by blocking the PDGF receptors with either the small tyrosine kinase inhibitor imatinib or blocking antibodies inhibits vascular mimicry and tumor growth. Collectively, the current study identifies an important role for pericytes in the formation of vascular-like structures by tumor cells. Moreover, the mechanism that controls the pericyte recruitment provides therapeutic opportunities for patients with aggressive vascular mimicry-positive cancer types. (c) 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Published
2018
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