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1. Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3)

Author

Contou, Damien, Pajot, Olivier, Jaubert, Paul, Marin, Nathalie, Simon, Marie, Cour, Martin, Mortaza, Satar, Souday, Vincent, Lemerle, Marie, Malfroy, Sylvain, Berdaguer Ferrari, Fernando, Rozec, Bertrand, Gruson, Didier, Sazio, Charline, Champion, Suzanne, Boissier, Florence, Veinstein, Anne, Baboi, Loredana, Richard, Jean-Christophe, Yonis, Hodane, Le Guennec, Loïc, Lefevre, Lucie, Chommeloux, Juliette, Hékimian, Guillaume, Lemiale, Virginie, Mariotte, Eric, Valade, Sandrine, Tirolien, Joanna, Fedun, Yannick, Cerf, Charles, Tachon, Guillaume, Roustan, Jérôme, Vimeux, Sylvie, Bonnivard, Michel, Anguel, Nadia, Osman, David, Asehnoune, Karim, Roquilly, Antoine, Belafia, Fouad, Conseil, Matthieu, Cisse, Moussa, Chaouki, Bouras, Espenel, Rémi, Brasse, Christine, Ena, Sébastien, Delahaye, Arnaud, Castanera, Jeremy, Dulac, Thierry, Petua, Philippe, Zerbib, Yoann, Brault, Clément, Annane, Djillali, Bounab, Rania, Heming, Nicholas, Boulain, Thierry, Jacquier, Sophie, Muller, Grégoire, Favory, Raphael, Préau, Sébastien, Poissy, Julien, Massri, Alexandre, Lissonde, Floriane, Winiszewski, Hadrien, Vieille, Thibault, Jacquier, Marine, Labruyère, Marie, Andreu, Pascal, Tadié, Jean-Marc, Bodenes, Laetitia, Combaux, Danièle, Luis, David, Marchalot, Antoine, Herbrecht, Jean-Etienne, Clere-Jehl, Raphaël, Schnell, David, Aboad, Jérôme, Bougon, David, Escudier, Etienne, Coupez, Elisabeth, Dupuis, Claire, Demailly, Zoe, Galerneau, Louis-Marie, Chelly, Jonathan, Pourcine, Franck, Van Vong, Ly, Abid, Sonia, De Montmollin, Etienne, Sonneville, Romain, Guitton, Christophe, Chudeau, Nicolas, Landais, Mickaël, Pages, Vincent, Séjourné, Caroline, Rahmani, Imen, Sbouj, Ghada, Megarbane, Bruno, Deye, Nicolas, Malissin, Isabelle, Reignier, Jean, Plantefeve, Gaetan, Mira, Jean-Paul, Argaud, Laurent, Asfar, Pierre, Aissaoui, Nadia, Badie, Julio, Botoc, Nicolae-Vlad, Brisard, Laurent, Bui, Hoang-Nam, Chatellier, Delphine, Chauvelot, Louis, Combes, Alain, Cracco, Christophe, Darmon, Michael, Das, Vincent, Debarre, Matthieu, Delbove, Agathe, Devaquet, Jérôme, Dumont, Louis-Marie, Gontier, Olivier, Groyer, Samuel, Guérin, Laurent, Guidet, Bertrand, Hourmant, Yannick, Jaber, Samir, Lambiotte, Fabien, Leroy, Christophe, Letocart, Philippe, Madeux, Benjamin, Maizel, Julien, Martinet, Olivier, Martino, Frédéric, Maxime, Virginie, Mercier, Emmanuelle, Nay, Mai-Anh, Nseir, Saad, Oziel, Johanna, Picard, Walter, Piton, Gael, Quenot, Jean-Pierre, Reizine, Florian, Renault, Anne, Richecoeur, Jack, Rigaud, Jean-Philippe, Schneider, Francis, Silva, Daniel, Sirodot, Michel, Souweine, Bertrand, Tamion, Fabienne, Terzi, Nicolas, Thévenin, Didier, Thiery, Guillaume, Thieulot-Rolin, Nathalie, Timsit, Jean-Francois, Tinturier, Francois, Tirot, Patrice, Vanderlinden, Thierry, Vinatier, Isabelle, Vinsonneau, Christophe, Voicu, Sebastian, Lascarrou, Jean-Baptiste, and Le Gouge, Amélie

Published
2023
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2. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Author

Souweine, Bertrand, Eisenmann, Nathanael, Quenot, Jean-Pierre, Seguin, Philippe, Asehnoune, Karim, Lasocki, Sigismond, Ferrandiere, Martine, Sossou, Achile, Langeron, Olivier, Leone, Marc, Dupont, Herve, Veber, Benoit, Ichai, Carole, Rimmelé, Thomas, Legay, François, Grelon, Fabien, Dahyot-Fizelier, Claire, Cayot, Sophie, Godet, Thomas, Guerin, Renaud, Verlhac, Camille, Chabanne, Russell, Cosserant, Bernard, Blondonnet, Raiko, Lautrette, Alexandre, Muller, Laurent, Massanet, Pablo, Boutin, Caroline, Barbar, Saber, Roger, Claire, Belafia, Fouad, Cisse, Moussa, Monnin, Marion, Conseil, Matthieu, Carr, Julie, De Jong, Audrey, Chanques, Gérald, Dargent, Auguste, Crozon, Thomas, Clauzel, Julien, Le Core, Marinne, Andreu, Pascal, Lebouvrier, Thomas, Launey, Yoann, Roquilly, Antoine, Cinotti, Raphael, Tellier, Anne-Charlotte, Barbaz, Mathilde, Cohen, Benjamin, Lemarche, Edouard, Bertrand, Pierre-Marie, Arbelot, Charlotte, Zieleskiewicz, Laurent, Hammad, Emmanuelle, Duclos, Garry, Calypso, Mathieu, Orban, Jean-Christophe, Quintard, Hervé, Assefi, Mona, Morel, Jerome, Molliex, Serge, Petitas, Frank, Nanadougmar, Hadanou, Jabaudon, Matthieu, Audard, Jules, Pereira, Bruno, Jaber, Samir, Lefrant, Jean-Yves, Futier, Emmanuel, Lambert, Céline, Bazin, Jean-Etienne, Bastarache, Julie A., Constantin, Jean-Michel, and Ware, Lorraine B.

Published
2020
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4. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial

Author

Jaber, Samir, de Jong, Audrey, Belafia, Fouad, Chanques, Gérald, Monnin, Marion, Delay, Jean-Marc, Cissé, Moussa, Geniez, Marie, Conseil, Matthieu, Souche, Bruno, Paugam, Catherine, Abback, Paër-Sélim, Futier, Emmanuel, Constantin, Jean Michel, Lefrant, Jean-Yves, Muller, Laurent, Lasocki, Sigismond, Lescot, Thomas, Pottecher, Julien, Noll, Eric, Demoule, Alexandre, Morawiec, Elise, Ferrandière, Martine, Asehnoune, Karim, Roquilly, Antoine, Dellamonica, Jean, Robert, Alexandre, Velly, Lionel, Triglia, Thibaut, Brunot, Vincent, Molinari, Nicolas, Mechati, Malika, Arnal, Jean-Michel, Durand-Gasselin, Jacques, Demoly, Didier, Hraiech, Sami, Papazian, Laurent, Gilles, Vincent, Rimmelé, Thomas, Riu, Béatrice, Cougot, Pierre, Fourcade, Olivier, Seguin, Philippe, Charbit, Jonathan, Capdevila, Xavier, Leone, Marc, Zieleskiewicz, Laurent, Ichai, Carole, Orban, Jean Christophe, Darmon, Michael, Azoulay, Elie, Lemiale, Virginie, Zafrani, Lara, Debbat, Karim, Mimoz, Oliver, Guérin, Claude, Kipnis, Eric, Constantin, Jean-Michel, Bertet, Helena, Klouche, Kada, and Jung, Boris

Published
2018
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6. Immediate interruption of sedation compared with usual sedation care in critically ill postoperative patients (SOS-Ventilation): a randomised, parallel-group clinical trial

Author

Chanques, Gerald, Conseil, Matthieu, Prades, Albert, Carr, Julie, Jung, Boris, Belafia, Fouad, Cissé, Moussa, Delay, Jean-Marc, De Jong, Audrey, Verzilli, Daniel, Clavieras, Noémie, Jaber, Samir, Mercier, Grégoire, Molinari, Nicolas, Mathieu, Emmanuelle, Bertet, Héléna, Roger, Claire, Muller, Laurent, Lefrant, Jean-Yves, Boutin, Caroline, Constantin, Jean-Michel, Futier, Emmanuel, Cayot, Sophie, Perbet, Sébastien, Jabaudon, Matthieu, and de Jong, Audrey

Published
2017
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7. Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3)

Author

Reignier, Jean, primary, Plantefeve, Gaetan, additional, Mira, Jean-Paul, additional, Argaud, Laurent, additional, Asfar, Pierre, additional, Aissaoui, Nadia, additional, Badie, Julio, additional, Botoc, Nicolae-Vlad, additional, Brisard, Laurent, additional, Bui, Hoang-Nam, additional, Chatellier, Delphine, additional, Chauvelot, Louis, additional, Combes, Alain, additional, Cracco, Christophe, additional, Darmon, Michael, additional, Das, Vincent, additional, Debarre, Matthieu, additional, Delbove, Agathe, additional, Devaquet, Jérôme, additional, Dumont, Louis-Marie, additional, Gontier, Olivier, additional, Groyer, Samuel, additional, Guérin, Laurent, additional, Guidet, Bertrand, additional, Hourmant, Yannick, additional, Jaber, Samir, additional, Lambiotte, Fabien, additional, Leroy, Christophe, additional, Letocart, Philippe, additional, Madeux, Benjamin, additional, Maizel, Julien, additional, Martinet, Olivier, additional, Martino, Frédéric, additional, Maxime, Virginie, additional, Mercier, Emmanuelle, additional, Nay, Mai-Anh, additional, Nseir, Saad, additional, Oziel, Johanna, additional, Picard, Walter, additional, Piton, Gael, additional, Quenot, Jean-Pierre, additional, Reizine, Florian, additional, Renault, Anne, additional, Richecoeur, Jack, additional, Rigaud, Jean-Philippe, additional, Schneider, Francis, additional, Silva, Daniel, additional, Sirodot, Michel, additional, Souweine, Bertrand, additional, Tamion, Fabienne, additional, Terzi, Nicolas, additional, Thévenin, Didier, additional, Thiery, Guillaume, additional, Thieulot-Rolin, Nathalie, additional, Timsit, Jean-Francois, additional, Tinturier, Francois, additional, Tirot, Patrice, additional, Vanderlinden, Thierry, additional, Vinatier, Isabelle, additional, Vinsonneau, Christophe, additional, Voicu, Sebastian, additional, Lascarrou, Jean-Baptiste, additional, Le Gouge, Amélie, additional, Contou, Damien, additional, Pajot, Olivier, additional, Jaubert, Paul, additional, Marin, Nathalie, additional, Simon, Marie, additional, Cour, Martin, additional, Mortaza, Satar, additional, Souday, Vincent, additional, Lemerle, Marie, additional, Malfroy, Sylvain, additional, Berdaguer Ferrari, Fernando, additional, Rozec, Bertrand, additional, Gruson, Didier, additional, Sazio, Charline, additional, Champion, Suzanne, additional, Boissier, Florence, additional, Veinstein, Anne, additional, Baboi, Loredana, additional, Richard, Jean-Christophe, additional, Yonis, Hodane, additional, Le Guennec, Loïc, additional, Lefevre, Lucie, additional, Chommeloux, Juliette, additional, Hékimian, Guillaume, additional, Lemiale, Virginie, additional, Mariotte, Eric, additional, Valade, Sandrine, additional, Tirolien, Joanna, additional, Fedun, Yannick, additional, Cerf, Charles, additional, Tachon, Guillaume, additional, Roustan, Jérôme, additional, Vimeux, Sylvie, additional, Bonnivard, Michel, additional, Anguel, Nadia, additional, Osman, David, additional, Asehnoune, Karim, additional, Roquilly, Antoine, additional, Belafia, Fouad, additional, Conseil, Matthieu, additional, Cisse, Moussa, additional, Chaouki, Bouras, additional, Espenel, Rémi, additional, Brasse, Christine, additional, Ena, Sébastien, additional, Delahaye, Arnaud, additional, Castanera, Jeremy, additional, Dulac, Thierry, additional, Petua, Philippe, additional, Zerbib, Yoann, additional, Brault, Clément, additional, Annane, Djillali, additional, Bounab, Rania, additional, Heming, Nicholas, additional, Boulain, Thierry, additional, Jacquier, Sophie, additional, Muller, Grégoire, additional, Favory, Raphael, additional, Préau, Sébastien, additional, Poissy, Julien, additional, Massri, Alexandre, additional, Lissonde, Floriane, additional, Winiszewski, Hadrien, additional, Vieille, Thibault, additional, Jacquier, Marine, additional, Labruyère, Marie, additional, Andreu, Pascal, additional, Tadié, Jean-Marc, additional, Bodenes, Laetitia, additional, Combaux, Danièle, additional, Luis, David, additional, Marchalot, Antoine, additional, Herbrecht, Jean-Etienne, additional, Clere-Jehl, Raphaël, additional, Schnell, David, additional, Aboad, Jérôme, additional, Bougon, David, additional, Escudier, Etienne, additional, Coupez, Elisabeth, additional, Dupuis, Claire, additional, Demailly, Zoe, additional, Galerneau, Louis-Marie, additional, Chelly, Jonathan, additional, Pourcine, Franck, additional, Van Vong, Ly, additional, Abid, Sonia, additional, De Montmollin, Etienne, additional, Sonneville, Romain, additional, Guitton, Christophe, additional, Chudeau, Nicolas, additional, Landais, Mickaël, additional, Pages, Vincent, additional, Séjourné, Caroline, additional, Rahmani, Imen, additional, Sbouj, Ghada, additional, Megarbane, Bruno, additional, Deye, Nicolas, additional, and Malissin, Isabelle, additional

Published
2023
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8. High-Flow Versus VenturiMask Oxygen Therapy to Prevent Reintubation in Hypoxemic Patients after Extubation: A Multicenter Randomized Clinical Trial

Author

Maggiore, Salvatore Maurizio, primary, Jaber, Samir, additional, Grieco, Domenico Luca, additional, Mancebo, Jordi, additional, Zakynthinos, Spyros, additional, Demoule, Alexandre, additional, Ricard, Jean-Damien, additional, Navalesi, Paolo, additional, Vaschetto, Rosanna, additional, Hraiech, Sami, additional, Klouche, Kada, additional, Frat, Jean-Pierre, additional, Lemiale, Virginie, additional, Fanelli, Vito, additional, Chanques, Gerald, additional, Natalini, Daniele, additional, Ischaki, Eleni, additional, Reuter, Danielle, additional, Morán, Indalecio, additional, La Combe, Béatrice, additional, Longhini, Federico, additional, De Gaetano, Andrea, additional, Ranieri, V. Marco, additional, Brochard, Laurent J., additional, Antonelli, Massimo, additional, Aarab, Yassir, additional, Azoulay, Elie, additional, Belafia, Fouad, additional, Berquier, Guillaume, additional, Conseil, Matthieu, additional, Costamagna, Andrea, additional, Dangers, Laurence, additional, Jong, Audrey De, additional, Delemazure, Julie, additional, Corte, Francesco Della, additional, Dell’Atti, Ivan, additional, Gaudry, Stèphane, additional, Grossi, Francesca, additional, Iovino, Giovanni Carmine, additional, Jean-Baptiste, Sylvain, additional, Laissi, Mohammed, additional, Larcher, Romaric, additional, Meur, Matthieu Le, additional, Leclaire, Clèment, additional, Lopez, Paula Andrea, additional, Malachias, Sotirios M., additional, Matteo, Marilena, additional, Mayaux, Julienne, additional, Messika, Jonathan, additional, Monet, Clement, additional, Morawiec, Elise, additional, Papazian, Laurent, additional, Parrilla, Francisco, additional, Platon, Laura, additional, Roux, Damien, additional, Santantonio, Maria Teresa, additional, Suarez, Juan Carlos, additional, Tanzarella, Eloisa Sofia, additional, Toni, Flavia, additional, and Vetrugno, Luigi, additional

Published
2022
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9. Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial

Author

Jaber, Samir, Monnin, Marion, Girard, Mehdi, Conseil, Matthieu, Cisse, Moussa, Carr, Julie, and Mahul, Martin

Subjects
Hospital patients -- Comparative analysis -- Health aspects, Health care industry
Abstract

Purpose High-flow nasal cannula oxygen (HFNC) has the potential to provide apnoeic oxygenation. We decided to assess in a proof-of-concept study whether the addition of HFNC to non-invasive ventilation (NIV) could reduce oxygen desaturation during intubation, compared with NIV alone for preoxygenation, in severely hypoxaemic intensive care unit (ICU) patients with respiratory failure. Methods We conducted a randomised, controlled, single-centre trial with assessor-blinded outcome assessment in patients admitted to the ICU. Hypoxaemic patients requiring orotracheal intubation for respiratory failure were randomised to receive preoxygenation using HFNC [flow = 60 L/min, fraction of inspired oxygen (FiO.sub.2) = 100 %] combined with NIV (pressure support = 10 cmH.sub.2O, positive end-expiratory pressure = 5 cmH.sub.2O, FiO.sub.2 = 100 %) in the intervention group or NIV alone in the reference group prior to intubation. The primary outcome was the lowest oxygen saturation (SpO.sub.2) during the intubation procedure. Secondary outcomes were intubation-related complications and ICU mortality. Results Between July 2015 and February 2016, we randomly assigned 25 and 24 patients to the intervention and reference groups, respectively. In both groups the main reasons for respiratory failure were pneumonia and ARDS. During the intubation procedure, the lowest SpO.sub.2 values were significantly higher in the intervention group than in the reference group [100 (95-100) % vs. 96 (92-99) %, p = 0.029]. After exclusion of two patients from analysis for protocol violation, no (0 %) patients in the intervention group and five (21 %) patients in the reference group had SpO.sub.2 below 80 % (p = 0.050). We recorded no significant difference between the groups in intubation-related complications or ICU mortality. Conclusions A novel strategy for preoxygenation in hypoxaemic patients, adding HFNC for apnoeic oxygenation to NIV prior to orotracheal intubation, may be more effective in reducing the severity of oxygen desaturation than the reference method using NIV alone., Author(s): Samir Jaber [sup.1] [sup.2], Marion Monnin [sup.1], Mehdi Girard [sup.1], Matthieu Conseil [sup.1], Moussa Cisse [sup.1], Julie Carr [sup.1], Martin Mahul [sup.1], Jean Marc Delay [sup.1], Fouad Belafia [sup.1], [...]

Published
2016
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10. Long-Term Outcome of Severe Metabolic Acidemia in ICU Patients, a BICAR-ICU Trial Post Hoc Analysis.

Author

Bendiab, Eddine, Garnier, Fanny, Soler, Marion, Fosset, Maxime, Jaber, Samir, Molinari, Nicolas, Jung, Boris, de Jong, Audrey, Belafia, Fouad, Chanques, Gérald, Monnin, Marion, Delay, Jean-Marc, Cissé, Moussa, Geniez, Marie, Conseil, Matthieu, Souche, Bruno, Paugam, Catherine, Abback, Paër-Sélim, Futier, Emmanuel, and Michel Constantin, Jean

Published
2023
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11. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Author

Jabaudon, Matthieu, primary, Audard, Jules, additional, Pereira, Bruno, additional, Jaber, Samir, additional, Lefrant, Jean-Yves, additional, Blondonnet, Raiko, additional, Godet, Thomas, additional, Futier, Emmanuel, additional, Lambert, Céline, additional, Bazin, Jean-Etienne, additional, Bastarache, Julie A., additional, Constantin, Jean-Michel, additional, Ware, Lorraine B., additional, Souweine, Bertrand, additional, Eisenmann, Nathanael, additional, Quenot, Jean-Pierre, additional, Seguin, Philippe, additional, Asehnoune, Karim, additional, Lasocki, Sigismond, additional, Ferrandiere, Martine, additional, Sossou, Achile, additional, Langeron, Olivier, additional, Leone, Marc, additional, Dupont, Herve, additional, Veber, Benoit, additional, Ichai, Carole, additional, Rimmelé, Thomas, additional, Legay, François, additional, Grelon, Fabien, additional, Dahyot-Fizelier, Claire, additional, Cayot, Sophie, additional, Guerin, Renaud, additional, Verlhac, Camille, additional, Chabanne, Russell, additional, Cosserant, Bernard, additional, Lautrette, Alexandre, additional, Muller, Laurent, additional, Massanet, Pablo, additional, Boutin, Caroline, additional, Barbar, Saber, additional, Roger, Claire, additional, Belafia, Fouad, additional, Cisse, Moussa, additional, Monnin, Marion, additional, Conseil, Matthieu, additional, Carr, Julie, additional, De Jong, Audrey, additional, Chanques, Gérald, additional, Dargent, Auguste, additional, Crozon, Thomas, additional, Clauzel, Julien, additional, Le Core, Marinne, additional, Andreu, Pascal, additional, Lebouvrier, Thomas, additional, Launey, Yoann, additional, Roquilly, Antoine, additional, Cinotti, Raphael, additional, Tellier, Anne-Charlotte, additional, Barbaz, Mathilde, additional, Cohen, Benjamin, additional, Lemarche, Edouard, additional, Bertrand, Pierre-Marie, additional, Arbelot, Charlotte, additional, Zieleskiewicz, Laurent, additional, Hammad, Emmanuelle, additional, Duclos, Garry, additional, Calypso, Mathieu, additional, Orban, Jean-Christophe, additional, Quintard, Hervé, additional, Assefi, Mona, additional, Morel, Jerome, additional, Molliex, Serge, additional, Petitas, Frank, additional, and Nanadougmar, Hadanou, additional

Published
2020
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12. Combination of Monocyte Human Leukocyte Antigen-DR and β-d-Glucan for the Early Diagnosis of Invasive Candida Infection in Critically Ill Patients: A Proof of Concept Study

Author

Jung, Boris, primary, Bihan, Clément Le, additional, Portales, Pierre, additional, Bourgeois, Nathalie, additional, Vincent, Thierry, additional, Lachaud, Laurence, additional, Chanques, Gerald, additional, Conseil, Matthieu, additional, Corne, Philippe, additional, Massanet, Pablo, additional, Timsit, Jean François, additional, and Jaber, Samir, additional

Published
2020
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13. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

Author

Jean-Michel Constantin, Matthieu Jabaudon, Jean-Yves Lefrant, Samir Jaber, Jean-Pierre Quenot, Olivier Langeron, Martine Ferrandière, Fabien Grelon, Philippe Seguin, Carole Ichai, Benoit Veber, Bertrand Souweine, Thomas Uberti, Sigismond Lasocki, François Legay, Marc Leone, Nathanael Eisenmann, Claire Dahyot-Fizelier, Hervé Dupont, Karim Asehnoune, Achille Sossou, Gérald Chanques, Laurent Muller, Jean-Etienne Bazin, Antoine Monsel, Lucile Borao, Jean-Marc Garcier, Jean-Jacques Rouby, Bruno Pereira, Emmanuel Futier, Cayot Sophie, Godet Thomas, Guerin Renaud, Verlac Camille, Chabanne Russel, Cosserant Bernard, Blondonnet Raiko, Lautrette Alexandre, Eisenmann Nathanael, Muller Laurent, Massanet Pablo, Boutin Caroline, Barbar Saber, Roger Claire, Belafia Fouad, Cisse Moussa, Monnin Marion, Conseil Matthieu, Carr Julie, De Jong Audrey, Dargent Auguste, Andreu Pascal, Lebouvrier Thomas, Launey Yoann, Roquilly Antoine, Cinotti Raphael, Tellier Anne-Charlotte, Barbaz Mathilde, Cohen Benjamin, Lemarche Edouard, Bertrand Pierre-Marie, Arberlot Charlotte, Zieleskiewicz Laurent, Hammad Emmanuelle, Duclos Garry, Mathie Calypso, Dupont Herve, Veber Benoit, Orban Jean-Christophe, Quintard Hervé, Rimmele Thomas, Crozon-Clauzel Julien, Le Core Marinne, Grelon Fabien, Assefi Mona, Petitas Frank, Morel Jerome, Molliex Serge, Hadanou Nanadougmar, CHU Clermont-Ferrand, Service d'Anésthésie Réanimation [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Réanimation Médicale (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Le Mans (CH Le Mans), CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de réanimation, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital St Roch, Département d'anesthésie-Réanimation-Samu, CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Unité de soins intensifs [Clermont Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Edouard Herriot Hospital, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU de Saint-Brieuc, Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Thérapeutiques cliniques et expérimentales des infections (EA 3826) (EA 3826), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Department of Anesthesiology and Critical Care Medicine, Emile-Roux general hospital, Le Puy-en-Velay, Université de Montpellier (UM), Immunologie - Immunopathologie - Immunothérapie (I3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Génétique, Reproduction et Développement (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Department of Perioperative Medicine, CHU Clermont-Ferrand, CHU Pitié-Salpêtrière [APHP], Hopital Général, Le Mans, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand-Hôpital Gabriel Montpied, Hospital General Saint-Brieuc, Hôpital Nord [CHU - APHM]-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU), Centre Régional de Lutte Contre le Cancer Jean Perrin, Centre hospitalier universitaire d'Amiens (CHU Amiens-Picardie), Service de réanimation adulte, département d'anesthésie-réanimation, CHU Clermont-Ferrand-Hôtel Dieu, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), University Hospital of Clermont-Ferrand, Institut Pascal - Clermont Auvergne (IP), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Unité de biostatistiques, CHU Clermont-Ferrand-Hôpital Montpied, Génétique, Reproduction et Développement - Clermont Auvergne (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), MORNET, Dominique, Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, ARDS, medicine.medical_treatment, [SDV]Life Sciences [q-bio], law.invention, Positive-Pressure Respiration, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Fraction of inspired oxygen, Intensive care, medicine, Prone Position, Tidal Volume, Humans, Single-Blind Method, 030212 general & internal medicine, Prospective Studies, Precision Medicine, Lung, Positive end-expiratory pressure, Tidal volume, ComputingMilieux_MISCELLANEOUS, Proportional Hazards Models, Mechanical ventilation, Respiratory Distress Syndrome, business.industry, Hazard ratio, Middle Aged, medicine.disease, Respiration, Artificial, 3. Good health, [SDV] Life Sciences [q-bio], Intensive Care Units, Editorial Commentary, Treatment Outcome, 030228 respiratory system, Female, France, business
Abstract

The effect of personalised mechanical ventilation on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remains uncertain and needs to be evaluated. We aimed to test whether a mechanical ventilation strategy that was personalised to individual patients' lung morphology would improve the survival of patients with ARDS when compared with standard of care.We designed a multicentre, single-blind, stratified, parallel-group, randomised controlled trial enrolling patients with moderate-to-severe ARDS in 20 university or non-university intensive care units in France. Patients older than 18 years with early ARDS for less than 12 h were randomly assigned (1:1) to either the control group or the personalised group using a minimisation algorithm and stratified according to the study site, lung morphology, and duration of mechanical ventilation. Only the patients were masked to allocation. In the control group, patients received a tidal volume of 6 mL/kg per predicted bodyweight and positive end-expiratory pressure (PEEP) was selected according to a low PEEP and fraction of inspired oxygen table, and early prone position was encouraged. In the personalised group, the treatment approach was based on lung morphology; patients with focal ARDS received a tidal volume of 8 mL/kg, low PEEP, and prone position. Patients with non-focal ARDS received a tidal volume of 6 mL/kg, along with recruitment manoeuvres and high PEEP. The primary outcome was 90-day mortality as established by intention-to-treat analysis. This study is registered online with ClinicalTrials.gov, NCT02149589.From June 12, 2014, to Feb 2, 2017, 420 patients were randomly assigned to treatment. 11 patients were excluded in the personalised group and nine patients were excluded in the control group; 196 patients in the personalised group and 204 in the control group were included in the analysis. In a multivariate analysis, there was no difference in 90-day mortality between the group treated with personalised ventilation and the control group in the intention-to-treat analysis (hazard ratio [HR] 1·01; 95% CI 0·61-1·66; p=0·98). However, misclassification of patients as having focal or non-focal ARDS by the investigators was observed in 85 (21%) of 400 patients. We found a significant interaction between misclassification and randomised group allocation with respect to the primary outcome (p0·001). In the subgroup analysis, the 90-day mortality of the misclassified patients was higher in the personalised group (26 [65%] of 40 patients) than in the control group (18 [32%] of 57 patients; HR 2·8; 95% CI 1·5-5·1; p=0·012.Personalisation of mechanical ventilation did not decrease mortality in patients with ARDS, possibly because of the misclassification of 21% of patients. A ventilator strategy misaligned with lung morphology substantially increases mortality. Whether improvement in ARDS phenotyping can decrease mortality should be assessed in a future clinical trial.French Ministry of Health (Programme Hospitalier de Recherche Clinique InterRégional 2013).

Published
2019
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14. Medical Versus Surgical ICU Obese Patient Outcome: A Propensity-Matched Analysis to Resolve Clinical Trial Controversies

Author

De Jong, Audrey, primary, Verzilli, Daniel, additional, Sebbane, Mustapha, additional, Monnin, Marion, additional, Belafia, Fouad, additional, Cisse, Moussa, additional, Conseil, Matthieu, additional, Carr, Julie, additional, Jung, Boris, additional, Chanques, Gérald, additional, Molinari, Nicolas, additional, and Jaber, Samir, additional

Published
2018
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15. Differential Perceptions of Noninvasive Ventilation in Intensive Care among Medical Caregivers, Patients, and Their Relatives

Author

Schmidt, Matthieu, primary, Boutmy-Deslandes, Emmanuelle, additional, Perbet, Sébastien, additional, Mongardon, Nicolas, additional, Dres, Martin, additional, Razazi, Keyvan, additional, Guerot, Emmanuel, additional, Terzi, Nicolas, additional, Andrivet, Pierre, additional, Alves, Mikael, additional, Sonneville, Romain, additional, Cracco, Christophe, additional, Peigne, Vincent, additional, Collet, Francois, additional, Sztrymf, Benjamin, additional, Rafat, Cedric, additional, Reuter, Danielle, additional, Fabre, Xavier, additional, Labbe, Vincent, additional, Tachon, Guillaume, additional, Minet, Clémence, additional, Conseil, Matthieu, additional, Azoulay, Elie, additional, Similowski, Thomas, additional, and Demoule, Alexandre, additional

Published
2016
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