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Your search keyword '"Conway, C M"' showing total 8 results
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8 results on '"Conway, C M"'

2. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

Author

Kostich, W., primary, Hamman, B. D., additional, Li, Y.-W., additional, Naidu, S., additional, Dandapani, K., additional, Feng, J., additional, Easton, A., additional, Bourin, C., additional, Baker, K., additional, Allen, J., additional, Savelieva, K., additional, Louis, J. V., additional, Dokania, M., additional, Elavazhagan, S., additional, Vattikundala, P., additional, Sharma, V., additional, Das, M. L., additional, Shankar, G., additional, Kumar, A., additional, Holenarsipur, V. K., additional, Gulianello, M., additional, Molski, T., additional, Brown, J. M., additional, Lewis, M., additional, Huang, Y., additional, Lu, Y., additional, Pieschl, R., additional, OMalley, K., additional, Lippy, J., additional, Nouraldeen, A., additional, Lanthorn, T. H., additional, Ye, G., additional, Wilson, A., additional, Balakrishnan, A., additional, Denton, R., additional, Grace, J. E., additional, Lentz, K. A., additional, Santone, K. S., additional, Bi, Y., additional, Main, A., additional, Swaffield, J., additional, Carson, K., additional, Mandlekar, S., additional, Vikramadithyan, R. K., additional, Nara, S. J., additional, Dzierba, C., additional, Bronson, J., additional, Macor, J. E., additional, Zaczek, R., additional, Westphal, R., additional, Kiss, L., additional, Bristow, L., additional, Conway, C. M., additional, Zambrowicz, B., additional, and Albright, C. F., additional

Published
2016
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5. Persistence of external signs in Pacific herring Clupea pallasii Valenciennes with ichthyophoniasis.

Author

Hart, L M, Conway, C M, Elliott, D G, and Hershberger, P K

Subjects
*ICHTHYOSPORIDIUM hoferi, *PACIFIC herring, *INFECTIONS in fish, *FISH mortality, *HISTOPATHOLOGY
Abstract

The progression of external signs of Ichthyophonus infection in Pacific herring Clupea pallasii Valenciennes was highly variable and asynchronous after intraperitoneal injection with pure parasite preparations; however, external signs generally persisted through the end of the study (429 days post-exposure). Observed signs included papules, erosions and ulcers. The prevalence of external signs plateaued 35 days post-exposure and persisted in 73-79% of exposed individuals through the end of the first experiment (147 days post-exposure). Among a second group of infected herring, external signs completely resolved in only 10% of the fish after 429 days. The onset of mortality preceded the appearance of external signs. Histological examination of infected skin and skeletal muscle tissues indicated an apparent affinity of the parasite for host red muscle. Host responses consisted primarily of granulomatous inflammation, fibrosis and necrosis in the skeletal muscle and other tissues. The persistence and asynchrony of external signs and host response indicated that they were neither a precursor to host mortality nor did they provide reliable metrics for hindcasting on the date of exposure. However, the long-term persistence of clinical signs in Pacific herring may be useful in ascertaining the population-level impacts of ichthyophoniasis in regularly observed populations. [ABSTRACT FROM AUTHOR]

Published
2016
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6. Detection of Ichthyophonus by chromogenic in situ hybridization.

Author

Conway, C M, Purcell, M K, Elliott, D G, and Hershberger, P K

Subjects
*ICHTHYOSPORIDIUM hoferi, *ICHTHYOSPORIDIUM, *IN situ hybridization, *NUCLEIC acid hybridization, *PROTISTA
Abstract

The article discusses the detection of Ichthyophonus by chromogenic in situ hybridization. It says that Ichthyophonus (I.) hoferi is a protistan parasite in the class Mesomycetozoea that infects a range of marine and freshwater fish. It adds that only two species, I. hoferi and I. irregularis, are recognized within the genus, at present.

Published
2015
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7. Infecting Pacific Herring with Ichthyophonussp. in the Laboratory

Author

Hershberger, P. K., Hart, L. M., MacKenzie, A. H., Yanney, M. L., Conway, C. M., and Elliott, D. G.

Abstract

The protistan parasite Ichthyophonussp. occurs in coastal populations of Pacific Herring Clupea pallasiithroughout the northeast Pacific region, but the route(s) by which these planktivorous fish become infected is unknown. Several methods for establishing Ichthyophonusinfections in laboratory challenges were examined. Infections were most effectively established after intraperitoneal (IP) injections with suspended parasite isolates from culture or after repeated feedings with infected fish tissues. Among groups that were offered the infected tissues, infection prevalence was greater after multiple feedings (65%) than after a single feeding (5%). Additionally, among groups that were exposed to parasite suspensions prepared from culture isolates, infection prevalence was greater after exposure by IP injection (74%) than after exposure via gastric intubation (12%); the flushing of parasite suspensions over the gills did not lead to infections in any of the experimental fish. Although the consumption of infected fish tissues is unlikely to be the primary route of Ichthyophonussp. transmission in wild populations of Pacific Herring, this route may contribute to abnormally high infection prevalence in areas where juveniles have access to infected offal. Received June 25, 2015; accepted September 12, 2015

Published
2015
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