73 results on '"Coudray, C."'
Search Results
2. Some Properties of Isolated Defects in Charged Mgo Clusters
- Author
-
Coudray, C., primary
- Published
- 2019
- Full Text
- View/download PDF
Catalog
3. Walking journeys into everyday climatic-affective atmospheres: The emotional labour of balancing grief and hope
- Author
-
Tschakert, Petra, Bourgault du Coudray, C., Horwitz, P., Tschakert, Petra, Bourgault du Coudray, C., and Horwitz, P.
- Abstract
The postapocalypse as a mobilising discourse for climate action operates largely out of anger over experienced and anticipated injustices as well as paradoxical hope that fuses loss and grief with freed-up solidarities in support of liveable futures. However, negotiating this emotional tension can be both draining and isolating. Here, we examine how white settler populations in Western Australia balance grief and hope in places they hold dear and the role emotions such as sadness, worry, disappointment, joy, and pride play in relational place making. Through an innovative in situ and mobile methodology we call Walking Journeys, we trace how participants navigate their climatic-affective atmospheres and make sense of their agency in changing ‘Places of the Heart’. We find evidence for emotional complexities of solastalgia where pessimistic outlooks for the future are wrapped up in prefigurative visions of a better world. By holding the tension between paralysis and restoration, urban and rural residents explore affective co-existence and differential belonging in their homes and the landscapes around them. We highlight the challenge of enfranchising emotions beyond individuals and conclude by endorsing entangled, reflexive, and (re-)generative responsibilities for hopeful postapocalyptic journeying. more...
- Published
- 2023
4. Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats
- Author
-
Universitat Rovira i Virgili, Cortés-Espinar, AJ; Ibarz-Blanch, N; Soliz-Rueda, JR; Bonafos, B; Feillet-Coudray, C; Casas, F; Bravo, FI; Calvo, E; Avila-Román, J; Mulero, M, Universitat Rovira i Virgili, and Cortés-Espinar, AJ; Ibarz-Blanch, N; Soliz-Rueda, JR; Bonafos, B; Feillet-Coudray, C; Casas, F; Bravo, FI; Calvo, E; Avila-Román, J; Mulero, M more...
- Abstract
Polyphenols play a key role in the modulation of circadian rhythms, while the cafeteria diet (CAF) is able to perturb the hepatic biological rhythm and induce important ROS production. Consequently, we aimed to elucidate whether grape seed proanthocyanidin extract (GSPE) administration recovers the CAF-induced hepatic antioxidant (AOX) misalignment and characterize the chronotherapeutic properties of GSPE. For this purpose, Fischer 344 rats were fed a standard diet (STD) or a CAF and concomitantly treated with GSPE at two time-points (ZT0 vs. ZT12). Animals were euthanized every 6 h and the diurnal rhythms of hepatic ROS-related biomarkers, hepatic metabolites, and AOX gene expression were examined. Interestingly, GSPE treatment was able to recover the diurnal rhythm lost due to the CAF. Moreover, GSPE treatment also increased the acrophase of Sod1, as well as bringing the peak closer to that of the STD group. GSPE also corrected some hepatic metabolites altered by the CAF. Importantly, the differences observed at ZT0 vs. ZT12 due to the time of GSPE administration highlight a chronotherapeutic profile on the proanthocyanin effect. Finally, GSPE could also reduce diet-induced hepatic oxidative stress not only by its ROS-scavenging properties but also by retraining the circadian rhythm of AOX enzymes. more...
- Published
- 2023
5. Influence of Crushing Conditions on Recycled Concrete Aggregates (RCA) Leaching Behaviour
- Author
-
Coudray, C., Amant, V., Cantegrit, L., Le Bocq, A., Thery, F., Denot, A., and Eisenlohr, L.
- Published
- 2017
- Full Text
- View/download PDF
6. Protective effect of myostatin gene deletion on aging-related muscle metabolic decline
- Author
-
Chabi, B., Pauly, M., Carillon, J., Carnac, G., Favier, F. B., Fouret, G., Bonafos, B., Vanterpool, F., Vernus, B., Coudray, C., Feillet-Coudray, C., Bonnieu, A., Lacan, D., and Koechlin-Ramonatxo, C. more...
- Published
- 2016
- Full Text
- View/download PDF
7. Le 9-PAHPA et le 9-OAHPA modulent le métabolisme basal et améliorent la sensibilité à l’insuline chez des souris nourries avec un régime obésogène
- Author
-
Benlebna, M., primary, Balas, L., additional, Bonafos, B., additional, Pessemesse, L., additional, Vigor, C., additional, Gaillet, S., additional, Durand, T., additional, Coudray, C., additional, Casas, F., additional, and Feillet-Coudray, C., additional more...
- Published
- 2021
- Full Text
- View/download PDF
8. PNS76 Why EARLY Access Price Should be Analyzed with Caution?
- Author
-
Coudray, C., primary and Gaugy, P., additional
- Published
- 2020
- Full Text
- View/download PDF
9. Impact de lipides bioactifs, les FAHFAs, sur les désordres métaboliques associés à l’obésité
- Author
-
Benlebna, M., primary, Balas, L., additional, Bonafos, B., additional, Pessemesse, L., additional, Fouret, G., additional, Gaillet, S., additional, Durand, T., additional, Coudray, C., additional, Casas, F., additional, and Feillet-Coudray, C., additional more...
- Published
- 2019
- Full Text
- View/download PDF
10. Inflammation et stress oxydant au cours du développement de l’intolérance au glucose et de la stéatose hépatique chez des rats nourris avec un régime obésogène
- Author
-
Feillet-Coudray, C., primary, Fouret, G., additional, Vigor, C., additional, Bonafos, B., additional, Jover, B., additional, Blachnio-Zabielska, A., additional, Rieusset, J., additional, Gaillet, S., additional, Durand, T., additional, and Coudray, C., additional more...
- Published
- 2019
- Full Text
- View/download PDF
11. Effets de la spiruline enrichie en silicium sur les composantes majeures du syndrome métabolique chez le rat Zucker obèse
- Author
-
Vidé, J., primary, Bonafos, B., additional, Fouret, G., additional, Jouy, N., additional, Coudray, C., additional, Gaillet, S., additional, and Feillet-Coudray, C., additional
- Published
- 2019
- Full Text
- View/download PDF
12. Valorisation des sédiments pour la production de ciments Portland
- Author
-
Faure, A., Coudray, C., Anger, B., Moulin, I., Colina, H., Izoret, L., Théry, F., Smith, Agnès, IRCER - Axe 1 : procédés céramiques (IRCER-AXE1), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and DERORY, BEATRICE more...
- Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,[SPI.MAT]Engineering Sciences [physics]/Materials - Published
- 2019
13. Valorisation des sédiments dans l’industrie cimentaire
- Author
-
Smith, Agnès, Faure, A., Coudray, C., ANGER, B., Colina, H., Moulin, I., Thery, F., DERORY, BEATRICE, IRCER - Axe 1 : procédés céramiques (IRCER-AXE1), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) more...
- Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,[SPI.MAT]Engineering Sciences [physics]/Materials - Published
- 2018
14. Calcined dam sediments as supplementary cementitious materials: characterization and pozzolanic reactivity
- Author
-
Faure, A., Smith, Agnès, Coudray, C., Anger, B., Colina, H., Moulin, I., Thery, F., Axe 1 : procédés céramiques (SPCTS-AXE1), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM), and DERORY, BEATRICE more...
- Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,ComputingMilieux_MISCELLANEOUS ,[SPI.MAT]Engineering Sciences [physics]/Materials - Abstract
International audience
- Published
- 2017
15. Dam fined-grained sediment as a novel resource for clinker manufacture
- Author
-
Faure, A., Smith, Agnès, Coudray, C., ANGER, B., Colina, H., Moulin, I., Thery, F., DERORY, BEATRICE, Axe 1 : procédés céramiques (SPCTS-AXE1), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM) more...
- Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,ComputingMilieux_MISCELLANEOUS ,[SPI.MAT]Engineering Sciences [physics]/Materials - Abstract
International audience
- Published
- 2017
16. Re-use opportunities of dam sediments as hydraulic and pozzolanic binders
- Author
-
Faure, A., Smith, Agnès, Coudray, C., ANGER, B., Colina, H., Moulin, I., Thery, F., DERORY, BEATRICE, Axe 1 : procédés céramiques (SPCTS-AXE1), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) more...
- Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,[SPI.MAT]Engineering Sciences [physics]/Materials - Published
- 2017
17. Calcined fine dam sediments as innovative binders: Optimization of the thermal treatment and pozzolanic activity assessment
- Author
-
Faure, A., Coudray, C., Anger, B., Smith, Agnès, Moulin, I., Colina, H., IRCER - Axe 1 : procédés céramiques (IRCER-AXE1), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Sherbrooke and the École des Mines de Douai., and DERORY, BEATRICE more...
- Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,ComputingMilieux_MISCELLANEOUS ,[SPI.MAT]Engineering Sciences [physics]/Materials - Abstract
International audience
- Published
- 2016
18. Reuse opportunities of dam fine sediments as hydraulic and pozzolanic binders
- Author
-
Faure, A., Smith, Agnès, Anger, B., Coudray, C., Colina, H., Moulin, I., Thery, F., IRCER - Axe 1 : procédés céramiques (IRCER-AXE1), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), and DERORY, BEATRICE more...
- Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry ,GeneralLiterature_INTRODUCTORYANDSURVEY ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,ComputingMilieux_MISCELLANEOUS ,[SPI.MAT]Engineering Sciences [physics]/Materials - Abstract
Prix du meilleur poster attribué par la maison d'édition Springer; International audience
- Published
- 2016
19. Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity.
- Author
-
Carper D, Lac M, Coue M, Labour A, Märtens A, Banda JAA, Mazeyrie L, Mechta M, Ingerslev LR, Elhadad M, Petit JV, Maslo C, Monbrun L, Del Carmine P, Sainte-Marie Y, Bourlier V, Laurens C, Mithieux G, Joanisse DR, Coudray C, Feillet-Coudray C, Montastier E, Viguerie N, Tavernier G, Waldenberger M, Peters A, Wang-Sattler R, Adamski J, Suhre K, Gieger C, Kastenmüller G, Illig T, Lichtinghagen R, Seissler J, Mounier R, Hiller K, Jordan J, Barrès R, Kuhn M, Pesta D, and Moro C more...
- Subjects
- Animals, Mice, Humans, Physical Endurance, Male, Mice, Knockout, Oxidative Phosphorylation, Insulin Resistance, Signal Transduction, Atrial Natriuretic Factor metabolism, Receptors, Atrial Natriuretic Factor metabolism, Receptors, Atrial Natriuretic Factor genetics, Muscle, Skeletal metabolism, Diabetes Mellitus, Type 2 metabolism, Diabetes Mellitus, Type 2 pathology, Mitochondria metabolism
- Abstract
Type 2 diabetes (T2D) and obesity are strongly associated with low natriuretic peptide (NP) plasma levels and a down-regulation of NP guanylyl cyclase receptor-A (GCA) in skeletal muscle and adipose tissue. However, no study has so far provided evidence for a causal link between atrial NP (ANP)/GCA deficiency and T2D pathogenesis. Here, we show that both systemic and skeletal muscle ANP/GCA deficiencies in mice promote metabolic disturbances and prediabetes. Skeletal muscle insulin resistance is further associated with altered mitochondrial function and impaired endurance running capacity. ANP/GCA-deficient mice exhibit increased proton leak and reduced content of mitochondrial oxidative phosphorylation proteins. We further show that GCA is related to several metabolic traits in T2D and positively correlates with markers of oxidative capacity in human skeletal muscle. Together, these results indicate that ANP/GCA signaling controls muscle mitochondrial integrity and oxidative capacity in vivo and plays a causal role in the development of prediabetes. more...
- Published
- 2024
- Full Text
- View/download PDF
20. NAVIGATE Program Directors' perspectives on treatment for early psychosis.
- Author
-
Coudray C, Williams-Wengerd A, Gingerich S, Glynn S, and Meyer-Kalos P
- Subjects
- Humans, United States, Psychotic Disorders psychology, Schizophrenia therapy
- Abstract
Objective: Since the release of the Recovery After Initial Schizophrenia Episode-Early Treatment Program results in 2015, the United States Congress expanded funding for early intervention programs and these programs now exist in every state. The purpose of the present study was to understand the real-world experience of NAVIGATE Program Directors with respect to identifying and recruiting patients with early psychosis and engaging families in treatment., Method: Utilizing a mixed-methods sequential explanatory design, researchers surveyed 32 program directors in 13 states and engaged in 22 follow-up interviews to explore how NAVIGATE is being translated to serve individuals experiencing early psychosis and their families., Results: We found that program directors using the NAVIGATE model encountered difficulty identifying diagnosis at admission and that supporting families of individuals experiencing psychosis was an important aspect of the program with unique complexity., Conclusions and Implications for Practice: These findings have important implications for future mental health research on early intervention programs and may serve to stimulate future research on how early intervention mental health programs can better serve individuals recovering from psychosis and support their families. (PsycInfo Database Record (c) 2024 APA, all rights reserved). more...
- Published
- 2023
- Full Text
- View/download PDF
21. Furan fatty acid extracted from Hevea brasiliensis latex increases muscle mass in mice.
- Author
-
Pelletier F, Durand E, Chaiyut J, Bronstein C, Pessemesse L, Vaysse L, Liengprayoon S, Gaillet S, Brioche T, Bertrand-Gaday C, Coudray C, Sultan A, Feillet-Coudray C, and Casas F
- Subjects
- Animals, Mice, Latex, Mice, Inbred C57BL, Muscle, Skeletal, Dietary Supplements, Fatty Acids, Furans pharmacology, Hevea
- Abstract
Skeletal muscle is essential for locomotion and plays a crucial role in energy homeostasis. It is regulated by nutrition, genetic factors, physical activity and hormones. Furan fatty acids (FuFAs) are minor fatty acids present in small quantities in food from plants and animals origin. Recently, we showed that a preventive nutritional supplementation with furan fatty acid in a DIO mouse model reduces metabolic disorders. The present study was designed to determine the influence of FuFA-F2 extracted from Hevea brasiliensis latex on skeletal muscle phenotype. In C2C12 myotubes we found that FuFA-F2 whatever the concentration used increased protein content. We revealed that in C2C12 myotubes FuFA-F2 (10 µM) increases protein synthesis as shown by the stimulation of mTOR phosphorylation. Next, to confirm in vivo our results C57Bl6 mice were supplemented by oral gavage with vehicle or FuFA-F2 (20 mg/kg) for 3 and a half weeks. We found that mice supplemented with FuFA-F2 had a greater lean mass than the control mice. In line with this observation, we revealed that FuFA-F2 increased muscle mass and promoted more oxidative muscle metabolism in mice as attested by cytochrome c oxidase activity. In conclusion, we demonstrated that FuFA-F2 stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. This study highlights that in vivo FuFA-F2 may have health benefits by increasing muscle mass and oxidative metabolism., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Masson SAS.) more...
- Published
- 2023
- Full Text
- View/download PDF
22. Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats.
- Author
-
Cortés-Espinar AJ, Ibarz-Blanch N, Soliz-Rueda JR, Bonafos B, Feillet-Coudray C, Casas F, Bravo FI, Calvo E, Ávila-Román J, and Mulero M
- Abstract
Polyphenols play a key role in the modulation of circadian rhythms, while the cafeteria diet (CAF) is able to perturb the hepatic biological rhythm and induce important ROS production. Consequently, we aimed to elucidate whether grape seed proanthocyanidin extract (GSPE) administration recovers the CAF-induced hepatic antioxidant (AOX) misalignment and characterize the chronotherapeutic properties of GSPE. For this purpose, Fischer 344 rats were fed a standard diet (STD) or a CAF and concomitantly treated with GSPE at two time-points (ZT0 vs. ZT12). Animals were euthanized every 6 h and the diurnal rhythms of hepatic ROS-related biomarkers, hepatic metabolites, and AOX gene expression were examined. Interestingly, GSPE treatment was able to recover the diurnal rhythm lost due to the CAF. Moreover, GSPE treatment also increased the acrophase of Sod1 , as well as bringing the peak closer to that of the STD group. GSPE also corrected some hepatic metabolites altered by the CAF. Importantly, the differences observed at ZT0 vs. ZT12 due to the time of GSPE administration highlight a chronotherapeutic profile on the proanthocyanin effect. Finally, GSPE could also reduce diet-induced hepatic oxidative stress not only by its ROS-scavenging properties but also by retraining the circadian rhythm of AOX enzymes. more...
- Published
- 2023
- Full Text
- View/download PDF
23. Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders.
- Author
-
Dore L, Durand E, Bonafos B, Chaiyut J, Vaysse L, Liengprayoon S, Gaillet S, Pessemesse L, Lambert K, Bertrand-Gaday C, Coudray C, Sultan A, Casas F, and Feillet-Coudray C
- Subjects
- Mice, Animals, Obesity drug therapy, Obesity prevention & control, Obesity metabolism, Diet, Dietary Supplements, Muscle, Skeletal, Fatty Acids metabolism, Insulin Resistance physiology
- Abstract
The increase in obesity has become a major global health problem and is associated with numerous metabolic dysfunctions. Furan fatty acids (FuFAs) are minor lipids present in our diet. Recently we showed that FuFA-F2 extracted from Hevea brasiliensis latex stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. While skeletal muscle is essential for energy metabolism and is the predominant site of insulin-mediated glucose uptake in the post prandial state, our results suggested that FuFA-F2 could have favorable effects against obesity. The aim of this work was therefore to study whether a preventive nutritional supplementation with FuFA-F2 (40 mg or 110 mg/day/kg of body weight) in a diet-induced obesity (DIO) mouse model may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. We showed that 12 weeks of FuFA-F2 supplementation in DIO mice decreased fat mass, increased lean mass and restored normal energy expenditure. In addition, we found that FuFA-F2 improved insulin sensitivity. We revealed that FuFA-F2 increased muscle mass but had no effect on mitochondrial function and oxidative stress in skeletal muscle. Furthermore, we observed that FuFA-F2 supplementation reduced liver steatosis without impact on mitochondrial function and oxidative stress in liver. Our findings demonstrated for the first time that a preventive nutritional supplementation with a furan fatty acid in DIO mice reduced metabolic disorders and was able to mimic partly the positive effects of physical activity. This study highlights that nutritional FuFA-F2 supplementation could be an effective approach to treat obesity and metabolic syndrome., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.) more...
- Published
- 2023
- Full Text
- View/download PDF
24. 9-PAHPA long term intake in DIO and db/db mice ameliorates insulin sensitivity but has few effects on obesity and associated metabolic disorders.
- Author
-
Bonafos B, Cortés-Espinar AJ, Balas L, Pessemesse L, Lambert K, Benlebna M, Gaillet S, Pelletier F, Delobel P, Ávila-Román J, Abellán MM, Bertrand-Gaday C, Durand T, Coudray C, Casas F, and Feillet-Coudray C more...
- Subjects
- Mice, Animals, Obesity metabolism, Diet, Liver metabolism, Weight Gain, Mice, Inbred Strains, Fatty Acids metabolism, Sucrose metabolism, Oleic Acids metabolism, Mice, Inbred C57BL, Diet, High-Fat adverse effects, Insulin Resistance, Metabolic Diseases etiology, Metabolic Diseases metabolism, Hyperglycemia metabolism
- Abstract
Branched fatty acid esters of hydroxy fatty acids are endogenous lipids reported to have antidiabetic and anti-inflammatory effects. Recently, we showed that 9-palmitic acid esters of hydroxypalmitic acid (9-PAHPA) and 9-oleic acid esters of hydroxypalmitic acid increased insulin sensitivity in mice when incorporated to a chow diet or to a high fat and high sucrose diet. However, preventive supplementation with 9-PAHPA and 9-oleic acid esters of hydroxypalmitic acid in high fat and high sucrose diet mice did not impair significant weight gain or the development of hyperglycemia. The aim of this work was therefore to study whether in two animal models of obesity, namely the classical diet-induced obesity (DIO) and the db/db mice, 9-PAHPA may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. In DIO mice, we observed that 9-PAHPA increased body weight and fat mass. In line with this observation, we found that 9-PAHPA supplementation decreased energy expenditure. In liver and in skeletal muscle, mitochondrial activities and oxidative stress parameters were not modified by 9-PAHPA supplementation. In db/db mice, 9-PAHPA had no effect on the dramatic weight gain and hyperglycemia. In addition, 9-PAHPA supplementation did not correct either the hepatomegaly and hepatic steatosis or the severe muscle atrophy recorded compared with db/+ animals. Likewise, supplementation with 9-PAHPA did not impact the different metabolic parameters analyzed, either in the liver or in the skeletal muscles. However, it decreased insulin resistance in DIO and db/db mice. In conclusion, our study indicated that a long-term intake of 9-PAHPA in DIO and db/db mice improved insulin sensitivity but had only few effects on obesity and associated metabolic disorders., (Copyright © 2022 Elsevier Inc. All rights reserved.) more...
- Published
- 2023
- Full Text
- View/download PDF
25. Impact of Highly Saturated versus Unsaturated Fat Intake on Carbohydrate Metabolism and Vascular Reactivity in Rat.
- Author
-
Djohan YF, Raynaud F, Lambert K, Cristol JP, Coudray C, Feillet-Coudray C, Virsolvy A, and Badia E
- Abstract
Palm olein (PO) and lard are considered harmful to health because of their highly saturated fatty acid content. On the contrary, olive oil (OO) with its high level of polyunsaturated fatty acids is considered healthier. This study aims to evaluate the effects of high consumption of these oils on carbohydrate metabolism and vascular function. Male Wistar rats were fed ad libitum for 12 weeks with different high fat diets (HFD) containing 30% of each oil. Systemic glycemia, insulinemia, and lipidemia were assessed by routine methods or by ELISA. GLUT4 muscular expression and hepatic and muscular Akt phosphorylation were analyzed by western blot. Vascular function was evaluated, ex vivo, on aortic rings and on the variations of isometric tensions. The results show that fasting blood glucose was increased with PO and OO diets and decreased with lard. Compared to control diet, this increase was significant only with PO diet. The area under the curve of IPGTT was increased in all HFD groups. Compared to control diet, this increase was significant only with PO. In contrast, stimulation of the pathway with insulin showed a significant decrease in Akt phosphorylation in all HFD compared to control diet. KCl and phenylephrine induced strong, dose-dependent vasoconstriction of rat aortas in all groups, but KCl EC
50 values were increased with lard and OO diets. The inhibitory effect of tempol was absent in PO and lard and attenuated in OO. Vascular insulin sensitivity was decreased in all HFD groups. This decreased sensitivity of insulin was more important with PO and lard when compared to OO diet. In conclusion, the results of this study clearly show that high consumption of palm olein, olive oil, and lard can compromise glucose tolerance and thus insulin sensitivity. Furthermore, palm olein and lard have a more deleterious effect than olive oil on the contractile function of the aorta. Excessive consumption of saturated or unsaturated fatty acids is harmful to health, regardless of their vegetable or animal origin., Competing Interests: The authors declare that they have no conflicts of interest regarding the publication of this paper., (Copyright © 2022 Youzan Ferdinand Djohan et al.) more...- Published
- 2022
- Full Text
- View/download PDF
26. Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver.
- Author
-
Djohan YF, Camara-Cissé M, Fouret G, Bonafos B, Jover B, Cristol JP, Coudray C, Feillet-Coudray C, and Badia E
- Abstract
Palm oil (crude or refined) and lard are rich in SFA, while olive oil is rich in polyunsaturated fatty acids. SFA are considered harmful to health, while polyunsaturated fatty acids are beneficial to health. The aim of this study was to determine the effect of diets rich in crude PO, refined PO, OO, or lard on the mitochondrial membrane, the activity of mitochondrial respiratory chain complexes, and mitochondrial biogenesis. This was an experimental study in male Wistar rats fed a diet containing 30% of each oil. Rats had free access to food and water. After being fed for 12 weeks, animals were sacrificed and liver mitochondria were collected. This collection was used to determine membrane potential and ROS production, membrane phospholipid and fatty acid composition, citrate synthase activity and respiratory chain complex, cardiolipin synthase protein expression, and expression of selected genes involved in mitochondrial biogenesis. We found that diets rich in olive oil, palm oil, or lard altered mitochondrial biogenesis by significantly decreasing Pgc1 α gene expression and altered the fatty acid composition of rat liver mitochondrial membrane PL., Competing Interests: The authors declare that they have no conflicts of interest regarding the publication of this paper., (Copyright © 2022 Youzan Ferdiand Djohan et al.) more...
- Published
- 2022
- Full Text
- View/download PDF
27. Time-of-Day Circadian Modulation of Grape-Seed Procyanidin Extract (GSPE) in Hepatic Mitochondrial Dynamics in Cafeteria-Diet-Induced Obese Rats.
- Author
-
Rodríguez RM, Cortés-Espinar AJ, Soliz-Rueda JR, Feillet-Coudray C, Casas F, Colom-Pellicer M, Aragonès G, Avila-Román J, Muguerza B, Mulero M, and Salvadó MJ
- Subjects
- Animals, Diet, Liver metabolism, Mitochondrial Dynamics, Obesity drug therapy, Obesity etiology, Obesity metabolism, Rats, Rats, Wistar, Grape Seed Extract pharmacology, Proanthocyanidins metabolism, Proanthocyanidins pharmacology, Vitis
- Abstract
Major susceptibility to alterations in liver function (e.g., hepatic steatosis) in a prone environment due to circadian misalignments represents a common consequence of recent sociobiological behavior (i.e., food excess and sleep deprivation). Natural compounds and, more concisely, polyphenols have been shown as an interesting tool for fighting against metabolic syndrome and related consequences. Furthermore, mitochondria have been identified as an important target for mediation of the health effects of these compounds. Additionally, mitochondrial function and dynamics are strongly regulated in a circadian way. Thus, we wondered whether some of the beneficial effects of grape-seed procyanidin extract (GSPE) on metabolic syndrome could be mediated by a circadian modulation of mitochondrial homeostasis. For this purpose, rats were subjected to "standard", "cafeteria" and "cafeteria diet + GSPE" treatments ( n = 4/group) for 9 weeks (the last 4 weeks, GSPE/vehicle) of treatment, administering the extract/vehicle at diurnal or nocturnal times (ZT0 or ZT12). For circadian assessment, one hour after turning the light on (ZT1), animals were sacrificed every 6 h (ZT1, ZT7, ZT13 and ZT19). Interestingly, GSPE was able to restore the rhythm on clock hepatic genes ( Bmal1 , Per2 , Cry1 , Rorα ), as this correction was more evident in nocturnal treatment. Additionally, during nocturnal treatment, an increase in hepatic fusion genes and a decrease in fission genes were observed. Regarding mitochondrial complex activity, there was a strong effect of cafeteria diet at nearly all ZTs, and GSPE was able to restore activity at discrete ZTs, mainly in the diurnal treatment (ZT0). Furthermore, a differential behavior was observed in tricarboxylic acid (TCA) metabolites between GSPE diurnal and nocturnal administration times. Therefore, GSPE may serve as a nutritional preventive strategy in the recovery of hepatic-related metabolic disease by modulating mitochondrial dynamics, which is concomitant to the restoration of the hepatic circadian machinery. more...
- Published
- 2022
- Full Text
- View/download PDF
28. Effects of high-fat diets on inflammation and antioxidant status in rats : comparison between palm olein and olive oil.
- Author
-
Djohan YF, Monde AA, Camara-Cissé M, Badia E, Bonafos B, Fouret G, Lauret C, Dupuy AM, Pinot E, Koffi G, Niamké G, Sutra T, Gaillet S, Lambert K, Raynaud F, Gayrard N, Jover B, Cristol JP, Coudray C, and Feillet-Coudray C more...
- Subjects
- Animals, Liver metabolism, Male, Oxidative Stress, Rats, Rats, Wistar, Antioxidants metabolism, Diet, High-Fat, Inflammation, Olive Oil administration & dosage, Palm Oil administration & dosage
- Abstract
Palm olein (PO) and olive oil (OO) are widely consumed in the world. PO is considered harmful to health, whereas OO is considered healthy. The aim of the study was to compare the effects of consumption of these oils on antioxidant status and inflammation in rats. This was an experimental study in male wistar rats fed a diet containing 30% of each oil. Rats had free access to food and water. After being fed for 12 weeks, animals were sacrificed and liver and aortic blood were collected. Plasma was used for the determination of interleukin-6 (IL-6) and oxidative stress parameters (Superoxide dismutase -SOD; Gluthation peroxidase - GPx; Thiobarbituric acid reactive substances - TBARS; Thiol groups and isoprostane). The inflammation and oxidative stress status as well as the expression of several genes/proteins were also analyzed in liver homogenate. No significant differences were observed between PO and OO in plasma and liver levels of the studied inflammation and oxidative stress parameters. This study showed that the consumption of PO induces an antioxidant status superimposable to that of OO. Key words : Palm olein - Olive oil - Oxidative stress - Inflammation - High fat diet. more...
- Published
- 2021
- Full Text
- View/download PDF
29. Prospective ultrasonographic follow-up of transvaginal lightweight meshes: a 1-year multicenter study.
- Author
-
Allègre L, Callewaert G, Coudray C, Demattei C, Panel L, Carlier-Guerin C, Letouzey V, de Tayrac R, and Fatton B
- Subjects
- Aged, Female, Follow-Up Studies, Humans, Prospective Studies, Surgical Mesh, Treatment Outcome, Cystocele, Pelvic Organ Prolapse
- Abstract
Introduction and Hypothesis: The use of new lightweight meshes in pelvic organ prolapse (POP) surgery may reduce complications related to mesh retraction (chronic pain, dyspareunia, and mesh exposure). The aim of this study was to investigate changes in the area and position of Uphold Lite™ mesh 6 weeks and 12 months after anterior and/or apical prolapse repair., Methods: This observational prospective multicenter study included patients who had undergone transvaginal surgery for symptomatic POP-Q stage ≥ II anterior and/or apical compartment prolapse with placement of Uphold Lite mesh. The dimensions and position of the mesh were evaluated at 6 weeks and 12 months by ultrasonography. Correlations between ultrasonographic mesh characteristics and POP recurrence were analyzed., Results: Fifty evaluable women with an average age of 66.8 years were included. No statistically significant difference in mesh area was found between week 6 and month 12 postoperatively, either at rest (1746.92 vs. 1574.48 mm
2 ; p = 0.15) or on Valsalva (1568.81 vs. 1542.98 mm2 ; p = 0.65). The ROC-AUC of the distance between the mesh and the bladder neck (M-BN) at 6 weeks for predicting cystocele recurrence at 12 months was 0.764 (95% CI 0.573-0.955) at rest and 0.724 (95% CI 0.533-0.916) on Valsalva. An M-BN distance > 12.5 mm could predict cystocele recurrence at month 12 with a sensitivity of 80% and a specificity of 69%., Conclusions: Ultrasonographic measurements of the Uphold Lite™ mesh appear to remain stable between 6 weeks and 12 months postoperatively. M-BN distance correlates with cystocele recurrence. These results appear to confirm the value of ultrasound in mesh evaluation. more...- Published
- 2021
- Full Text
- View/download PDF
30. Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice.
- Author
-
Benlebna M, Balas L, Bonafos B, Pessemesse L, Fouret G, Vigor C, Gaillet S, Grober J, Bernex F, Landrier JF, Kuda O, Durand T, Coudray C, Casas F, and Feillet-Coudray C
- Subjects
- Animals, Basal Metabolism, Insulin metabolism, Lipid Metabolism, Liver metabolism, Mice, Mice, Inbred C57BL, Diabetes Mellitus, Experimental metabolism, Insulin Resistance
- Abstract
Purpose: Fatty acid esters of hydroxy fatty acids (FAHFAs) are a large family of endogenous bioactive lipids. To date, most of the studied FAHFAs are branched regioisomers of Palmitic Acid Hydroxyl Stearic Acid (PAHSA) that were reported to possess anti-diabetic and anti-inflammatory activity in humans and rodents. Recently, we have demonstrated that 9-PAHPA or 9-OAHPA intake increased basal metabolism and enhanced insulin sensitivity in healthy control diet-fed mice but induced liver damage in some mice. The present work aims to explore whether a long-term intake of 9-PAHPA or 9-OAHPA may have similar effects in obesogenic diet-fed mice., Methods: C57Bl6 mice were fed with a control or high fat-high sugar (HFHS) diets for 12 weeks. The HFHS diet was supplemented or not with 9-PAHPA or 9-OAHPA. Whole-body metabolism was explored. Glucose and lipid metabolism as well as mitochondrial activity and oxidative stress status were analyzed., Results: As expected, the intake of HFHS diet led to obesity and lower insulin sensitivity with minor effects on liver parameters. The long-term intake of 9-PAHPA or 9-OAHPA modulated favorably the basal metabolism and improved insulin sensitivity as measured by insulin tolerance test. On the contrary to what we have reported previously in healthy mice, no marked effect for these FAHFAs was observed on liver metabolism of obese diabetic mice., Conclusion: This study indicates that both 9-PAHPA and 9-OAHPA may have interesting insulin-sensitizing effects in obese mice with lower insulin sensitivity. more...
- Published
- 2021
- Full Text
- View/download PDF
31. Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats.
- Author
-
Laget J, Djohan YF, Jeanson L, Muyor K, Badia E, Cristol JP, Coudray C, Feillet-Coudray C, Vigor C, Oger C, Galano JM, Durand T, Lajoix AD, Gayrard N, and Jover B
- Subjects
- Adipose Tissue pathology, Animals, Blood Glucose, Body Weight, Diet, High-Fat adverse effects, Glucose metabolism, Lipids blood, Macrophages drug effects, Macrophages physiology, Male, Rats, Rats, Wistar, Adipose Tissue drug effects, Dietary Fats administration & dosage, Inflammation chemically induced, Palm Oil administration & dosage
- Abstract
Excessive fat consumption leads to the development of ectopic adipose tissues, affecting the organs they surround. Peripancreatic adipose tissue is implicated in glucose homeostasis regulation and can be impaired in obesity. High palm oil consumption's effects on health are still debated. We hypothesised that crude and refined palm oil high-fat feeding may have contrasting effects on peripancreatic adipocyte hypertrophy, inflammation and lipid oxidation compound production in obese rats. In Wistar rats, morphological changes, inflammation and isoprostanoid production following oxidative stress were assessed in peripancreatic adipose tissue after 12 weeks of diets enriched in crude or refined palm oil or lard (56% energy from fat in each case) versus a standard chow diet (11% energy from fat). Epididymal white and periaortic brown adipose tissues were also included in the study. A refined palm oil diet disturbed glucose homeostasis and promoted lipid deposition in periaortic locations, as well as adipocyte hypertrophy, macrophage infiltration and isoprostanoid (5-F
2c -isoprostane and 7 (RS) -ST-Δ8 -11-dihomo-isofuran) production in peripancreatic adipose tissue. Crude palm oil induced a lower impact on adipose deposits than its refined form and lard. Our results show that the antioxidant composition of crude palm oil may have a protective effect on ectopic adipose tissues under the condition of excessive fat intake. more...- Published
- 2021
- Full Text
- View/download PDF
32. p43, a Truncated Form of Thyroid Hormone Receptor α, Regulates Maturation of Pancreatic β Cells.
- Author
-
Blanchet E, Pessemesse L, Feillet-Coudray C, Coudray C, Cabello C, Bertrand-Gaday C, and Casas F
- Subjects
- Animals, Female, Insulin-Secreting Cells metabolism, Maf Transcription Factors, Large genetics, Male, Mice, Mice, Knockout, Oxidative Stress, Cell Differentiation, Gene Expression Regulation, Insulin Secretion, Insulin-Secreting Cells cytology, Maf Transcription Factors, Large metabolism, Thyroid Hormone Receptors alpha physiology
- Abstract
P43 is a truncated form of thyroid hormone receptor α localized in mitochondria, which stimulates mitochondrial respiratory chain activity. Previously, we showed that deletion of p43 led to reduction of pancreatic islet density and a loss of glucose-stimulated insulin secretion in adult mice. The present study was designed to determine whether p43 was involved in the processes of β cell development and maturation. We used neonatal, juvenile, and adult p43-/- mice, and we analyzed the development of β cells in the pancreas. Here, we show that p43 deletion affected only slightly β cell proliferation during the postnatal period. However, we found a dramatic fall in p43-/- mice of MafA expression (V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog A), a key transcription factor of beta-cell maturation. Analysis of the expression of antioxidant enzymes in pancreatic islet and 4-hydroxynonenal (4-HNE) (a specific marker of lipid peroxidation) staining revealed that oxidative stress occurred in mice lacking p43. Lastly, administration of antioxidants cocktail to p43-/- pregnant mice restored a normal islet density but failed to ensure an insulin secretion in response to glucose. Our findings demonstrated that p43 drives the maturation of β cells via its induction of transcription factor MafA during the critical postnatal window. more...
- Published
- 2021
- Full Text
- View/download PDF
33. Potential physio-pathological effects of branched fatty acid esters of hydroxy fatty acids.
- Author
-
Benlebna M, Balas L, Gaillet S, Durand T, Coudray C, Casas F, and Feillet-Coudray C
- Subjects
- Animals, Cardiovascular Diseases pathology, Diabetes Mellitus, Type 2 pathology, Fatty Liver pathology, Humans, Neoplasms pathology, Cardiovascular Diseases metabolism, Diabetes Mellitus, Type 2 metabolism, Fatty Acids metabolism, Fatty Liver metabolism, Insulin Resistance, Neoplasms metabolism
- Abstract
Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) are a new endogenous lipid class with recently uncovered interesting biological effects and which have been detected in food of plant and animal origins. Some FAHFAs can improve glucose tolerance and insulin sensitivity, stimulate insulin secretion, and exert anti-inflammatory effects. Other beneficial health effects have also been suggested, in particular against some cancers. FAHFAs could therefore be a potential therapeutic target for the treatment of numerous metabolic disorders such as type II diabetes, hepatic steatosis, cardiovascular diseases and various cancers. Their recent discovery has generated a great interest in the field of human health. This short review aims at bringing together the information available to date in the literature concerning their chemical synthesis, biosynthesis and degradation pathways as well as their potential physio-pathological beneficial effects., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.) more...
- Published
- 2021
- Full Text
- View/download PDF
34. FAHFAs Regulate the Proliferation of C2C12 Myoblasts and Induce a Shift toward a More Oxidative Phenotype in Mouse Skeletal Muscle.
- Author
-
Benlebna M, Balas L, Pessemesse L, Bonafos B, Fouret G, Pavlin L, Goustard B, Gaillet S, Durand T, Coudray C, Feillet-Coudray C, and Casas F
- Subjects
- Animals, Cell Differentiation drug effects, Cell Line, Cell Proliferation, Electron Transport drug effects, Electron Transport Complex IV metabolism, Esters chemistry, Fatty Acids chemistry, Gene Expression Regulation drug effects, Mice, Inbred C57BL, Mitochondria drug effects, Mitochondria metabolism, Muscle, Skeletal, Oxidation-Reduction, Phenotype, RNA, Messenger genetics, RNA, Messenger metabolism, Receptors, G-Protein-Coupled genetics, Receptors, G-Protein-Coupled metabolism, Esters pharmacology, Fatty Acids pharmacology, Myoblasts cytology
- Abstract
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids reported to have antidiabetic and anti-inflammatory effects. Since skeletal muscle is a major target for insulin, the aim of this study is to explore for the first time the influence of several FAHFAs in C2C12 myoblasts and in skeletal muscle phenotype in mice. Here, we show that eleven FAHFAs belonging to different families inhibit C2C12 myoblast proliferation. In addition, all FAHFAs decreased mitochondrial cytochrome c oxidase activity without affecting reactive oxygen species production and the mitochondrial network. During C2C12 myoblasts differentiation, we found that two of the most active lipids, 9-PAHPA and 9-OAHPA, did not significantly affect the fusion index and the expression of myosin heavy chains. However, we found that three months' intake of 9-PAHPA or 9-OAHPA in mice increased the expression of more oxidative myosin in skeletal muscle without affecting skeletal muscle mass, number, and mean fiber area, mitochondrial activity, and oxidative stress parameters. In conclusion, our study indicated that the eleven FAHFAs tested decreased the proliferation rate of C2C12 myoblasts, probably through the inhibition of mitochondrial activity. In addition, we found that 9-PAHPA or 9-OAHPA supplementation in mice induced a switch toward a more oxidative contractile phenotype of skeletal muscle. These data suggest that the increase in insulin sensitivity previously described for these two FAHFAs is of muscular origin. more...
- Published
- 2020
- Full Text
- View/download PDF
35. Impact of diets rich in olive oil, palm oil or lard on myokine expression in rats.
- Author
-
Gauze-Gnagne C, Raynaud F, Djohan YF, Lauret C, Feillet-Coudray C, Coudray C, Monde A, Koffi G, Morena M, Camara-Cisse M, Cristol JP, and Badia E
- Subjects
- Animals, Glucose metabolism, Glucose Transporter Type 4 genetics, Glucose Transporter Type 4 metabolism, Insulin metabolism, Lipid Metabolism, Male, Mitochondria genetics, Mitochondria metabolism, Rats, Rats, Wistar, Dietary Fats metabolism, Muscle, Skeletal metabolism, Olive Oil metabolism, Palm Oil metabolism
- Abstract
It has recently emerged that myokines may be an important skeletal muscle adaptive response to obesogenic diets in sedentary subjects (who do not exercise). This study aimed to assess the influence of various high fat (HF) diets rich in either crude palm oil (cPO), refined palm oil (rPO), olive oil (OO) or lard on the modulation of myokine gene expression in the gastrocnemius. Five groups of 8 rats were each fed HF or control diet for 12 weeks. Systemic parameters concerning glucose, insulin, inflammation, cholesterol, triglycerides (TG) and transaminases were assessed by routine methods or ELISA. Akt and ACC phosphorylation were analyzed by WB in the soleus. Mitochondrial density, inflammation, and the gene expression of 17 myokines and the apelin receptor (Apj) were assessed by qPCR in the gastrocnemius. We found that HF diet-fed rats were insulin resistant and Akt phosphorylation decreased in the soleus muscle, but without any change in Glut4 gene expression. Systemic (IL-6) and muscle inflammation (NFκB and IκB) were not affected by the HF diets as well as TBARS, and ASAT level was enhanced with OO diet. Soleus pACC phosphorylation and gastrocnemius mitochondrial density were not significantly altered. The gene expression of some myokines was respectively increased (myostatin and Il-15) and decreased (Fndc5 and apelin) with the HF diets, whatever the type of fat used. The gene expression of two myokines with anti-inflammatory properties, Il-10 and myonectin, was dependent on the type of fat used and was most increased respectively with cPO or both rPO and OO diets. In conclusion, high-fat diets can differentially modulate the expression of some myokines, either in a dependent manner or independently of their composition. more...
- Published
- 2020
- Full Text
- View/download PDF
36. Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice.
- Author
-
Benlebna M, Balas L, Bonafos B, Pessemesse L, Vigor C, Grober J, Bernex F, Fouret G, Paluchova V, Gaillet S, Landrier JF, Kuda O, Durand T, Coudray C, Casas F, and Feillet-Coudray C
- Subjects
- Adipose Tissue, White drug effects, Adipose Tissue, White metabolism, Animals, Blood Glucose analysis, Body Weight drug effects, Energy Metabolism, Fatty Acids administration & dosage, Fatty Acids adverse effects, Fatty Liver metabolism, Glucose Tolerance Test, Homeostasis, Inflammation metabolism, Insulin metabolism, Lipid Metabolism, Liver Cirrhosis metabolism, Male, Mice, Mice, Inbred C57BL, Basal Metabolism drug effects, Fatty Acids pharmacology, Insulin Resistance, Liver metabolism
- Abstract
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a new family of endogenous lipids recently discovered. Several studies reported that some FAHFAs have antidiabetic and anti-inflammatory effects. The objective of this study was to explore the impact of two FAHFAs, 9-PAHPA or 9-OAHPA, on the metabolism of mice. C57Bl/6J male mice, 6 weeks old, were divided into 3 groups of 10 mice each. One group received a control diet and the two others groups received the control diet supplemented with 9-PAHPA or 9-OAHPA for 12 weeks. Mouse weight and body composition were monitored throughout the study. Some days before euthanasia, energy expenditure, glucose tolerance and insulin sensitivity were also determined. After sacrifice, blood and organs were collected for relevant molecular, biochemical and histological analyses. Although high intake of 9-PAHPA or 9-OAHPA increased basal metabolism, it had no direct effect on body weight. Interestingly, the 9-PAHPA or 9-OAHPA intake increased insulin sensitivity but without modifying glucose tolerance. Nevertheless, 9-PAHPA intake induced a loss of glucose-stimulated insulin secretion. Surprisingly, both studied FAHFAs induced hepatic steatosis and fibrosis in some mice, which were more marked with 9-PAHPA. Finally, a slight remodeling of white adipose tissue was also observed with 9-PAHPA intake. In conclusion, the long-term high intake of 9-PAHPA or 9-OAHPA increased basal metabolism and insulin sensitivity in healthy mice. However, this effect, highly likely beneficial in a diabetic state, was accompanied by manifest liver damage in certain mice that should deserve special attention in both healthy and pathological studies., Competing Interests: Conflict of interest The authors confirm that this article content has no conflict of interest., (Copyright © 2020 Elsevier Inc. All rights reserved.) more...
- Published
- 2020
- Full Text
- View/download PDF
37. High dietary intake of palm oils compromises glucose tolerance whereas high dietary intake of olive oil compromises liver lipid metabolism and integrity.
- Author
-
Djohan YF, Badia E, Bonafos B, Fouret G, Lauret C, Dupuy AM, Pinot E, Sutra T, Gaillet S, Lambert K, Raynaud F, Gayrard N, Jover B, Monde AA, Cristol JP, Coudray C, and Feillet-Coudray C
- Subjects
- Animals, Male, Models, Animal, Olive Oil administration & dosage, Palm Oil administration & dosage, Rats, Rats, Wistar, Diet methods, Glucose metabolism, Lipid Metabolism physiology, Liver metabolism, Olive Oil pharmacology, Palm Oil pharmacology
- Abstract
Purpose: Palm (PO) and olive oils (OO) are the two most consumed and/or used oils in the world for food elaboration. These oils should not be confused with the solid palm stearin which is widely used in pastry making. Large number of studies was reported dealing with adverse/beneficial cardiovascular effects of PO and OO, whereas few studies were conducted to compare their potential effects on hepatic steatosis and liver lipid metabolism. The aim of this study was to compare the metabolic effects of high intake of POs (both crude and refined) and virgin OO on surrogate parameters of glucose tolerance, hepatic lipid metabolism and liver integrity., Methods: Thirty-two young male Wistar rats were divided into four equal groups and fed either control diet (11% energy from fat) or three high-fat diets rich in crude or refined POs or in OO (56% energy from fat), during 12 weeks. Systemic blood and liver biochemical parameters linked to glucose and lipid metabolism as well as hepatic steatosis and liver fatty acid composition were explored. The inflammation and oxidative stress status as well as the expression of several genes/proteins were also analyzed., Results: The major effects of POs intake concerned glucose metabolism and liver fatty acid composition, whereas the major effects of OO intake concerned hepatic TG accumulation, inflammation, and cytolysis., Conclusions: In conclusion, high dietary intake of PO compromises glucose tolerance whereas high dietary intake of OO compromises hepatic lipid composition and liver integrity. However, adverse hepatic effects of OO observed in this study may not be transposed to human since, (a) the rodent model could lead to different effects than those observed in humans and (b) the average normal OO amounts ingested in the population are lower than those corresponding to a high-fat diet. So, further studies are needed to determine a maximum non-invasive dietary intake of OO. more...
- Published
- 2019
- Full Text
- View/download PDF
38. Moderators of the efficacy of a web-based stress management intervention for college students.
- Author
-
Coudray C, Palmer R, and Frazier P
- Subjects
- Adolescent, Counseling methods, Female, Humans, Male, Outcome Assessment, Health Care, Psychotherapy methods, Therapy, Computer-Assisted trends, Treatment Outcome, Young Adult, Internet, Stress, Psychological psychology, Stress, Psychological therapy, Students psychology, Therapy, Computer-Assisted methods, Universities
- Abstract
High levels of stress are common among college students. Web-based interventions may be one way to teach students stress management skills. Although previous research has demonstrated the overall efficacy of web-based stress management interventions, little attention has been paid to who might benefit most from these interventions. In this study, we analyzed data from 3 prior studies ( N = 782) to examine moderators of the efficacy of a web-based stress management intervention that focused on increasing perceived present control (i.e., aspects of stressors that are controllable in the present). Specific moderators assessed in regression analyses were baseline scores on outcome measures (perceived stress, stress symptoms, anxiety, depression) and the putative mechanism (perceived present control) of the intervention. Baseline symptom levels moderated the effects of the intervention on all outcomes, such that the intervention was more effective for students with more baseline symptoms. Baseline levels of present control had less consistent moderating effects, but significant interactions indicated that the intervention was more effective for those with lower levels of present control. The novel Johnson-Neyman technique was used to identify specific cutoff scores on these measures, below which the effect of the intervention was not significant, and scores on the measures associated with varying effect sizes. Findings from the Johnson-Neyman analyses can inform the development of screening criteria for future research and clinical application. Because the intervention was more effective for students with higher levels of baseline distress, it may be better suited for an indicated rather than universal prevention approach. (PsycINFO Database Record (c) 2019 APA, all rights reserved). more...
- Published
- 2019
- Full Text
- View/download PDF
39. Effect of spirulina and silicon-enriched spirulina on metabolic syndrome features, oxidative stress and mitochondrial activity in Zucker fatty rats.
- Author
-
Vidé J, Bonafos B, Fouret G, Casas F, Jover B, Jouy N, Feillet-Coudray C, Gaillet S, and Coudray C
- Subjects
- Animal Feed, Animals, Diet, Dietary Supplements, Fatty Liver prevention & control, Glucose Tolerance Test, Lipid Metabolism drug effects, Lipids blood, Lipids chemistry, Liver chemistry, Male, Mitochondria metabolism, Mitochondria, Liver metabolism, Mitochondria, Muscle metabolism, Random Allocation, Rats, Rats, Zucker, Metabolic Syndrome prevention & control, Mitochondria drug effects, Mitochondria, Liver drug effects, Mitochondria, Muscle drug effects, Silicon chemistry, Spirulina
- Abstract
The use of Spirulina platensis (Sp) as a functional food was suggested decades ago. Biological incorporation of Silicon (Si) into Sp increases its bioavailability for potential food supplement applications. This work aimed at determining the effects of Sp and Si-enriched Sp (Sp+Si) on metabolic syndrome features in Zucker fatty rats. Thirty Zucker fatty rats were divided into three groups and supplemented with placebo or Sp or Sp+Si croquettes for 12 weeks. Food consumption, glucose intolerance, hepatic steatosis, and mitochondrial and oxidative stress were determined. Zucker fatty rats exhibited several hepatic metabolic alterations as well as mitochondrial and oxidative stress perturbations. The intake of Sp increased plasma TG levels and decreased the hepatic NADPH oxidase activity and ameliorated transitorily the glucose intolerance. However, Si-spirulina does not appear to have more beneficial effects than spirulina alone. Other experiments with different species of rats/mice, different diets, or durations of diet intake should be undertaken to confirm or infirm these results. PRACTICAL APPLICATIONS: Glucose intolerance and hepatic steatosis, two major components of metabolic syndrome, are increasing and becomes a major public health issue. Use of Spirulina platensis (Sp) as a functional food was suggested as a protein-dense food source. Bioavailable silicon (Si) may be an essential nutrient for higher animals, including humans. Sp but not Sp+Si decreased liver NADPH oxidase activity and improved transitorily glucose tolerance. This is the first study where Sp and Sp+Si effect on glucose intolerance is reported in Zucker rat. Other experiments should be undertaken to confirm or infirm invalidate the beneficial effects of Sp+Si supplement in the metabolic syndrome features., (© 2019 Wiley Periodicals, Inc.) more...
- Published
- 2019
- Full Text
- View/download PDF
40. New evidence of exercise training benefits in myostatin-deficient mice: Effect on lipidomic abnormalities.
- Author
-
Baati N, Feillet-Coudray C, Fouret G, Vernus B, Goustard B, Jollet M, Bertrand-Gaday C, Coudray C, Lecomte J, Bonnieu A, and Koechlin-Ramonatxo C
- Subjects
- Animals, Lipidomics, Male, Mice, Mice, Knockout, Myostatin metabolism, Physical Conditioning, Animal, Physical Endurance, Running, Gene Deletion, Lipid Metabolism, Myostatin genetics
- Abstract
Myostatin (Mstn) inactivation or inhibition is considered as a promising treatment for various muscle-wasting disorders because it promotes muscle growth. However, myostatin-deficient hypertrophic muscles show strong fatigability associated with abnormal mitochondria and lipid metabolism. Here, we investigated whether endurance training could improve lipid metabolism and mitochondrial membrane lipid composition in mice where the Mstn gene was genetically ablated (Mstn
-/- mice). In Mstn-/- mice, 4 weeks of daily running exercise sessions (65-70% of the maximal aerobic speed for 1 h) improved significantly aerobic performance, particularly the endurance capacity (up to +280% compared with untrained Mstn-/- mice), to levels comparable to those of trained wild type (WT) littermates. The expression of oxidative and lipid metabolism markers also was increased, as indicated by the upregulation of the Cpt1, Ppar-δ and Fasn genes. Moreover, endurance training also increased, but far less than WT, citrate synthase level and mitochondrial protein content. Interestingly endurance training normalized the cardiolipin fraction in the mitochondrial membrane of Mstn-/- muscle compared with WT. These results suggest that the combination of myostatin inhibition and endurance training could increase the muscle mass while preserving the physical performance with specific effects on cardiolipin and lipid-related pathways., (Copyright © 2019 Elsevier Inc. All rights reserved.) more...- Published
- 2019
- Full Text
- View/download PDF
41. Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats.
- Author
-
Wang Y, Fouret G, Bonafos B, Blachnio-Zabielska A, Leroy T, Crouzier D, Barea B, Gaillet S, Moro C, Lecomte J, Coudray C, and Feillet-Coudray C
- Subjects
- Animals, Ceramides metabolism, Fatty Acids analysis, Fatty Acids metabolism, Fructose metabolism, Homeostasis, Male, Mitochondria, Muscle drug effects, Mitochondria, Muscle metabolism, Muscle, Skeletal metabolism, Oxidative Stress drug effects, Phospholipids chemistry, Phospholipids metabolism, Rats, Wistar, Reactive Oxygen Species metabolism, Diet, High-Fat adverse effects, Fructose adverse effects, Glucose metabolism, Lipid Metabolism drug effects, Muscle, Skeletal drug effects
- Abstract
Metabolic syndrome components, including obesity, dyslipidemia and impaired glucose homeostasis, become a major public health issue. Muscles play a predominant role in insulin-mediated glucose uptake, and high fat diets may negatively affect muscle function and homeostasis. This work aimed to study the time-course of muscle lipid accumulation, oxidative stress and mitochondrial dysfunction and their association to impaired glucose homeostasis in rats fed an obesogenic diet. Male Wistar rats were fed with a standard or a high fat/high fructose (HFHFr) diet and sacrificed on 4, 8, 12, 16, 20 weeks. Rats fed the HFHFr diet developed mild overweight, increased liver and adipose tissue weights and glucose intolerance. The impaired glucose homeostasis increased gradually with the HFHFr diet to become significant on the 12th and 16th weeks of diet. In parallel, the muscle lipid composition showed an increase in the saturated fatty acids and the monounsaturated fatty acids with a marked decrease in the polyunsaturated fatty acids. The HFHFr diet also increased muscle contents of both diacylglycerols and Ceramides. Surprisingly, HFHFr diet did not induce major muscle mitochondrial dysfunction or oxidative stress. These results indicate that muscle lipid alterations, as well as impaired glucose homeostasis occur as early as the 8th week of HFHFr diet, increase to reach a plateau around the 12th-16th weeks of diet, and then attenuate towards the end of study. At these diet treatment durations, muscle mitochondrial activity and oxidative stress remained unchanged and do not seem to have a major role in the observed impaired glucose homeostasis., (Copyright © 2018 Elsevier Inc. All rights reserved.) more...
- Published
- 2019
- Full Text
- View/download PDF
42. Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High-Fat/High-Fructose Diet.
- Author
-
Feillet-Coudray C, Fouret G, Vigor C, Bonafos B, Jover B, Blachnio-Zabielska A, Rieusset J, Casas F, Gaillet S, Landrier JF, Durand T, and Coudray C
- Subjects
- Animals, Blood Glucose metabolism, Inflammation blood, Liver metabolism, Male, Rats, Rats, Wistar, Reactive Oxygen Species metabolism, Superoxide Dismutase metabolism, Thiobarbituric Acid Reactive Substances metabolism, Diet, High-Fat adverse effects, Dyslipidemias immunology, Dyslipidemias metabolism, Fructose adverse effects, Inflammation metabolism, Oxidative Stress drug effects
- Abstract
Inflammation and oxidative stress are thought to be involved in, or associated with, the development of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. This work was designed to determine the evolution of inflammation and oxidative stress during onset and progression of hepatic steatosis and glucose intolerance. Seventy-five male Wistar rats were divided to control and high-fat high-fructose (HFHFr) groups. A subgroup of each group was sacrificed at 4, 8, 12, 16, and 20 weeks. HFHFr-fed rats exhibited overweight, glucose intolerance, and hepatic steatosis with increased contents of hepatic diacylglycerols and ceramides. The HFHFr diet increased hepatic interleukin 6 (IL-6) protein and adipose tissue CCL5 gene expression and hepatic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity but not mitochondrial reactive oxygen species (ROS) production. The HFHFr diet decreased plasma and liver levels of isoprostanoid metabolites as well as plasma thiobarbituric acid-reactive substance (TBARS) levels. Hepatic glutathione content was decreased with a moderate decrease in superoxide dismutase (SOD) and glutathione peroxidase (GPx) with the HFHFr diet. Overall, HFHFr diet led to hepatic lipid accumulation and glucose intolerance, which were accompanied by only moderate inflammation and oxidative stress. Most of these changes occurred at the same time and as early as 8 or 12 weeks of diet treatment. This implies that oxidative stress may be the result, not the cause, of these metabolic alterations, and suggests that marked hepatic oxidative stress should probably occur at the end of the steatotic stage to result in frank insulin resistance and steatohepatitis. These findings need to be further evaluated in other animal species as well as in human studies., (© 2019 AOCS.) more...
- Published
- 2019
- Full Text
- View/download PDF
43. Supported Internet-Delivered Cognitive Behavioral Therapy Programs for Depression, Anxiety, and Stress in University Students: Open, Non-Randomised Trial of Acceptability, Effectiveness, and Satisfaction.
- Author
-
Palacios JE, Richards D, Palmer R, Coudray C, Hofmann SG, Palmieri PA, and Frazier P
- Abstract
Background: Many university campuses have limited mental health services that cannot cope with the high demand. One alternative is to use internet-delivered cognitive behavioral therapy (iCBT) as a way of tackling barriers such as lack of availability and scheduling issues., Objective: This study aimed to assess feasibility, acceptability, effectiveness, and satisfaction of a supported iCBT intervention offering 3 programs on depression, anxiety, and stress to university students. The design was an open or nonrandomized feasibility trial., Methods: Participants were recruited from 3 counseling centers at a large midwestern University in the United States. Those agreeing to take part chose 1 of 3 iCBT programs-Space from Depression, Space from Anxiety, or Space from Stress -all comprised 8 modules of media-rich interactive content. Participants were supported throughout the trial by a trained professional. The Patient Health Questionnaire 9 (PHQ-9), Generalized Anxiety Disorder 7 (GAD-7) questionnaire, and stress subscale of the Depression Anxiety and Stress Scale (DASS-21) were completed at baseline, 8 weeks, and 3-month follow-up. A Satisfaction With Treatment (SAT) questionnaire was completed at 8 weeks, and qualitative interviews were completed by a subsample of participants at 3 months., Results: A total of 102 participants were recruited, with 52 choosing Space from Anxiety, 31 choosing Space from Depression, and 19 choosing Space from Stress. Mixed-effects models showed a significant decrease in symptoms of depression (F
4 =6.36, P<.001), anxiety (F4 =7.97, P<.001), and stress (F4 =8.50, P<.001) over time across all 3 programs. The largest decreases in PHQ-9 scores at 8 weeks were among participants who chose the Space from Depression program (d=0.84); at 3 months, the largest decreases in PHQ-9 scores were among those who chose the Space from Stress program (d=0.74). The largest decreases in GAD-7 scores were among those who chose the Space from Anxiety program (d=0.74 at 8 weeks and d=0.94 at 3 months). The largest decrease in DASS-21 stress subscale scores was among those who chose the Space from Stress program (d=0.49 at 8 weeks and d=1.16 at 3 months). The mean time spent using the platform per session was 27.4 min (SD 33.8), and participants completed 53% (SD 37.6) of the total program content on average. Most (37/53, 69%) participants found the programs helpful or very helpful and liked the convenience and flexibility of the intervention. Qualitative interviews (n=14) indicated the intervention met students' expectations, and they saw it as a valuable complement to face-to-face treatment., Conclusions: The iCBT programs tested in our study appear to be feasible, acceptable, and effective in a university environment. Participants described the benefits of having a flexible, supported Web-based intervention available on campus. Larger trials should be conducted to further test the effectiveness of supported Web-based interventions that give students a choice of program depending on their symptom profile., (©Jorge E Palacios, Derek Richards, Riley Palmer, Carissa Coudray, Stefan G Hofmann, Patrick A Palmieri, Patricia Frazier. Originally published in JMIR Mental Health (http://mental.jmir.org), 14.12.2018.) more...- Published
- 2018
- Full Text
- View/download PDF
44. Spirulina platensis and silicon-enriched spirulina equally improve glucose tolerance and decrease the enzymatic activity of hepatic NADPH oxidase in obesogenic diet-fed rats.
- Author
-
Vidé J, Bonafos B, Fouret G, Benlebna M, Poupon J, Jover B, Casas F, Jouy N, Feillet-Coudray C, Gaillet S, and Coudray C
- Subjects
- Animals, Glucose Tolerance Test, Humans, Liver drug effects, Liver metabolism, Male, NADPH Oxidases genetics, Obesity enzymology, Obesity genetics, Obesity metabolism, Rats, Rats, Wistar, Silicon analysis, Spirulina chemistry, Glucose metabolism, Liver enzymology, NADPH Oxidases metabolism, Obesity diet therapy, Silicon metabolism, Spirulina metabolism
- Abstract
The prevalence of metabolic syndrome components, such as obesity, glucose intolerance and hepatic steatosis, is rapidly increasing and becoming a major issue of public health. The present work was designed to determine the effects of Spirulina platensis (Sp) algae and silicon-enriched Sp on major metabolic syndrome components in obesogenic diet-fed rats. Forty male Wistar rats were divided into 4 groups. Ten rats were fed a control diet and 30 rats were fed a high fat (HF) diet. The HF groups were divided into three groups and supplemented with placebo or Sp or Si-enriched Sp for 12 weeks. Dietary intake and body weight were recorded. Oral glucose tolerance test and surrogate metabolic syndrome (insulin, leptin, adiponectin and lipids), mitochondrial function (enzymatic activity of respiratory chain complexes and β-hydroxyacyl-CoA dehydrogenase), NADPH oxidase activity and several long-established oxidative stress markers were measured in the blood and liver. The HF diet induced obesity, glucose intolerance, hepatic steatosis and huge metabolic alterations, associated with higher NADPH oxidase activity and lower hepatic sulfhydryl group and glutathione contents. Otherwise, the Sp and Sp + Si supplements showed some interesting effects on rat characteristics and particularly on blood and hepatic metabolic parameters. Indeed, the intake of Sp or Sp + Si mainly improved glucose tolerance and decreased the enzymatic activity of hepatic NADPH oxidase. Overall, Si supplementation of spirulina does not appear to have more beneficial effects than spirulina alone. Other experiments with different species of rats/mice, different diets or different durations of diet intake should be undertaken to confirm or invalidate these results. more...
- Published
- 2018
- Full Text
- View/download PDF
45. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently.
- Author
-
Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, and Koulman A
- Subjects
- Animals, Biomarkers, Diet, Fatty Acids administration & dosage, Gas Chromatography-Mass Spectrometry, Male, Rats, Rats, Sprague-Dawley, Rats, Wistar, Dietary Fats administration & dosage, Fatty Acids blood
- Abstract
Pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) have been described as dietary biomarkers of dairy-fat consumption, with varying degrees of reliability between studies. It remains unclear how the total amount of dietary fat, representing one of the main confounding factors in these biomarker investigations, affects C15:0 and C17:0 circulating concentrations independent of their relative intake. Additionally, it is not clear how changes in the dietary total-fat affects other fatty acids in circulation. Through two dietary studies with different total-fat levels but maintaining identical fatty acid compositions, we were able to see how the dietary total-fat affects the fatty acids in circulation. We saw that there was a statistically significant, proportionate, and robust decrease in the endogenous C15:0 levels with an increase in dietary total-fat. However, there was no significant change in the circulating C17:0 concentrations as the total-fat increased. To conclude, the dietary total-fat content and fat-type have a very complex influence on the relative compositions of circulating fatty acids, which are independent of the actual dietary fatty acid composition. Knowing how to manipulate circulating C15:0 and C17:0 concentrations is far-reaching in nutritional/pathological research as they highlight a dietary route to attenuate the development of metabolic disease (both by reducing risk and improving prognosis). more...
- Published
- 2018
- Full Text
- View/download PDF
46. Branched Fatty Acyl Esters of Hydroxyl Fatty Acids (FAHFAs), Appealing Beneficial Endogenous Fat against Obesity and Type-2 Diabetes.
- Author
-
Balas L, Feillet-Coudray C, and Durand T
- Subjects
- Esters, Humans, Diabetes Mellitus, Type 2 drug therapy, Fatty Acids chemistry, Fatty Acids pharmacology, Obesity drug therapy
- Abstract
After a brief overview of the biological significance of FAHFAs, the present Minireview highlights the different strategies developed for their chemical syntheses. The term "FAHFAs" has been introduced in 2014 for fatty acyl esters of hydroxyl fatty acids, found in adipocytes, with antidiabetic properties. However, many other natural products contain this type of branched lipids in their structure. This review was then extended to the synthesis of these subunits, even though the length of the lipid chains and the location of the ester linkages are different, since the developed strategies may be applied to the synthesis of "FAHFA"., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.) more...
- Published
- 2018
- Full Text
- View/download PDF
47. Toxicity of Natural Deep Eutectic Solvent Betaine:Glycerol in Rats.
- Author
-
Benlebna M, Ruesgas-Ramón M, Bonafos B, Fouret G, Casas F, Coudray C, Durand E, Cruz Figueroa-Espinoza M, and Feillet-Coudray C
- Subjects
- Animals, Betaine analysis, Coffea chemistry, Glycerol analysis, Male, Plant Extracts analysis, Rats, Rats, Wistar, Seeds chemistry, Solvents analysis, Solvents toxicity, Betaine toxicity, Glycerol toxicity, Plant Extracts toxicity
- Abstract
Natural deep eutectic solvents (NaDES) are new natural solvents in green chemistry that in some cases have been shown to allow better extraction of plant bioactive molecules compared to conventional solvents and higher phenolic compound absorption in rodents. However, there is a serious lack of information regarding their in vivo safety. The purpose of this study was to verify the safety of a NaDES (betaine:glycerol (1:2 mole ratio) of water) extract from green coffee beans, rich in polyphenols. Twelve 6-week-old male Wistar rats were randomized into two groups of 6 animals each and twice daily gavaged for 14 days either with 3 mL of water or 3 mL of phenolic NaDES extract. Oral administration of phenolic NaDES extract induced mortality in two rats. In addition, it induced excessive water consumption, reduced dietary intake and weight loss, hepatomegaly, and plasma oxidative stress associated with high blood lipid levels. In conclusion, this work demonstrated the toxicity of oral administration of the selected NaDES under a short-term condition. This occurs despite the fact that this NaDES extract contains polyphenols, whose beneficial effects have been shown. Therefore, complementary work is needed to find the best dose and formulation of NaDES that are safe for the environment and animals and ultimately for humans. more...
- Published
- 2018
- Full Text
- View/download PDF
48. Skeletal muscle overexpression of short isoform Sirt3 altered mitochondrial cardiolipin content and fatty acid composition.
- Author
-
Chabi B, Fouret G, Lecomte J, Cortade F, Pessemesse L, Baati N, Coudray C, Lin L, Tong Q, Wrutniak-Cabello C, Casas F, and Feillet-Coudray C
- Subjects
- Animals, Electron Transport, Mice, Mitochondrial Membranes chemistry, Mitochondrial Membranes metabolism, Phospholipids metabolism, Protein Isoforms, Cardiolipins metabolism, Fatty Acids metabolism, Mitochondria metabolism, Muscle, Skeletal metabolism, Sirtuin 3 physiology
- Abstract
Cardiolipin (CL) is a phospholipid at the heart of mitochondrial metabolism, which plays a key role in mitochondrial function and bioenergetics. Among mitochondrial activity regulators, SIRT3 plays a crucial role in controlling the acetylation status of many enzymes participating in the energy metabolism in particular concerning lipid metabolism and fatty acid oxidation. Data suggest that possible connection may exist between SIRT3 and CL status that has not been evaluated in skeletal muscle. In the present study, we have characterized skeletal muscle lipids as well as mitochondrial lipids composition in mice overexpressing long (SIRT3-M1) and short (SIRT3-M3) isoforms of SIRT3. Particular attention has been paid for CL. We reported no alteration in muscle lipids content and fatty acids composition between the two mice SIRT3 strains and the control mice. However, mitochondrial CL content was significantly decreased in SIRT3-M3 mice and associated to an upregulation of tafazzin gene expression. In addition, mitochondrial phospholipids and fatty acids composition was altered with an increase in the PC/PE ratio and arachidonic acid content and a reduction in the MUFA/SFA ratio. These modifications in mitochondrial membrane composition are associated with a reduction in the enzymatic activities of mitochondrial respiratory chain complexes I and IV. In spite of these mitochondrial enzymatic alterations, skeletal muscle mitochondrial respiration remained similar in SIRT3-M3 and control mice. Surprisingly, none of those metabolic alterations were detected in mitochondria from SIRT3-M1 mice. In conclusion, our data indicate a specific action of the shorter SIRT3 isoform on lipid mitochondrial membrane biosynthesis and functioning. more...
- Published
- 2018
- Full Text
- View/download PDF
49. Combination of nutritional polyphenols supplementation with exercise training counteracts insulin resistance and improves endurance in high-fat diet-induced obese rats.
- Author
-
Lambert K, Hokayem M, Thomas C, Fabre O, Cassan C, Bourret A, Bernex F, Feuillet-Coudray C, Notarnicola C, Mercier J, Avignon A, and Bisbal C
- Subjects
- Animals, Body Weight drug effects, Glucose Tolerance Test, Male, Muscle, Skeletal drug effects, Muscle, Skeletal metabolism, Muscle, Skeletal physiopathology, Obesity chemically induced, Obesity physiopathology, Oxidation-Reduction drug effects, Polyphenols therapeutic use, Rats, Rats, Sprague-Dawley, Diet, High-Fat adverse effects, Dietary Supplements, Insulin Resistance, Obesity drug therapy, Obesity metabolism, Physical Conditioning, Animal, Polyphenols pharmacology
- Abstract
Separately, polyphenols and exercise are known to prevent insulin resistance (IR) but their combined curative effects on established obesity and IR require further investigation. Therefore, we compared the metabolic effects of a combination of exercise and grape polyphenols supplementation in obese IR rats with high-fat diet (EXOPP) to the effect of high-fat diet alone (HF) or with a nutritional supplementation of grape polyphenols (PP) or with endurance exercise (EXO) during 8 wks. We observed an improvement of systemic and skeletal muscle insulin sensitivity in EXO and EXOPP rats. EXOPP rats compared to HF rats presented a lower insulinemia and HOMA-IR with higher liver and muscle glycogen contents. Interestingly, EXOPP rats had a 68% enhanced endurance capacity compared to EXO rats with also a higher activation of AMPK compared to sedentary and EXO rats with increased lipid oxidation. Together, our results suggest that grape polyphenols supplementation combined with exercise has a synergistic effect by increasing muscle lipid oxidation and sparing glycogen utilization which thus enhances endurance capacity. Our data highlight that in cases of established obesity and IR, the combination of nutritional grape polyphenols supplementation and exercise heighten and intensify their individual metabolic effects. more...
- Published
- 2018
- Full Text
- View/download PDF
50. 20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet.
- Author
-
Fouret G, Gaillet S, Lecomte J, Bonafos B, Djohan F, Barea B, Badia E, Coudray C, and Feillet-Coudray C
- Subjects
- Adipose Tissue growth & development, Analysis of Variance, Animals, Cell Respiration, Dietary Carbohydrates administration & dosage, Dietary Carbohydrates adverse effects, Glucose Intolerance diagnosis, Hyperglycemia etiology, Hyperinsulinism etiology, Lipids analysis, Liver chemistry, Male, Membrane Potential, Mitochondrial, Mitochondria, Liver chemistry, Mitochondria, Liver physiology, Overweight etiology, Phospholipids chemistry, Phospholipids classification, Phospholipids isolation & purification, Phospholipids metabolism, Random Allocation, Rats, Rats, Wistar, Reactive Oxygen Species metabolism, Diet, High-Fat adverse effects, Fatty Liver etiology, Fructose administration & dosage, Fructose adverse effects, Mitochondria, Liver pathology
- Abstract
The incidence of obesity and its metabolic complications are rapidly increasing and become a major public health issue. This trend is associated with an increase in the prevalence of non-alcoholic fatty liver disease (NAFLD), insulin resistance and diabetes. The sequence of events leading to NAFLD progression and mitochondrial dysfunction and their interrelation remains to be elucidated. This study aimed to explore the installation and progression of NAFLD and its association with the liver mitochondrial structure and activity changes in rats fed an obesogenic diet up to 20 weeks. Male Wistar rats were fed either a standard or high-fat-high-fructose (HFHFR) diet and killed on 4, 8, 12, 16 and 20 weeks of diet intake. Rats fed the HFHFR diet developed mildly overweight, associated with increased adipose tissue weight, hepatic steatosis, hyperglycaemia and hyperinsulinaemia after 8 weeks of HFHFR diet. Hepatic steatosis and many biochemical modifications plateaued at 8-12 weeks of HFHFR diet with slight amelioration afterwards. Interestingly, several biochemical and physiological parameters of mitochondrial function, as well as its phospholipid composition, in particular cardiolipin content, were tightly related to hepatic steatosis installation. These results showed once again the interrelation between hepatic steatosis development and mitochondrial activity alterations without being able to say whether the mitochondrial alterations preceded or followed the installation/progression of hepatic steatosis. Because both hepatic steatosis and mitochondrial alterations occurred as early as 4 weeks of diet, future studies should consider these four 1st weeks to reveal the exact interconnection between these major consequences of obesogenic diet intake. more...
- Published
- 2018
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.