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20 results on '"Cowart, Beverly J."'

3. Denatonium benzoate bitter taste perception in chronic rhinosinusitis subgroups

Author

Civantos, Alyssa M., primary, Maina, Ivy W., additional, Arnold, Monique, additional, Lin, Cailu, additional, Stevens, Elizabeth M., additional, Tan, Li Hui, additional, Gleeson, Patrick K., additional, Colquitt, Lauren R., additional, Cowart, Beverly J., additional, Bosso, John V., additional, Palmer, James N., additional, Adappa, Nithin D., additional, Kohanski, Michael A., additional, Reed, Danielle R., additional, and Cohen, Noam A., additional

Published
2020
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4. Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients

Author

Lin, Cailu, primary, Civantos, Alyssa M., additional, Arnold, Monique, additional, Stevens, Elizabeth M., additional, Cowart, Beverly J., additional, Colquitt, Lauren R., additional, Mansfield, Corrine, additional, Kennedy, David W., additional, Brooks, Steven G., additional, Workman, Alan D., additional, Blasetti, Mariel T., additional, Kohanski, Michael A., additional, Doghramji, Laurel, additional, Douglas, Jennifer E., additional, Maina, Ivy W., additional, Palmer, James N., additional, Adappa, Nithin D., additional, Reed, Danielle R., additional, and Cohen, Noam A., additional

Published
2020
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6. Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients.

Author

Lin, Cailu, Civantos, Alyssa M., Arnold, Monique, Stevens, Elizabeth M., Cowart, Beverly J., Colquitt, Lauren R., Mansfield, Corrine, Kennedy, David W., Brooks, Steven G., Workman, Alan D., Blasetti, Mariel T., Kohanski, Michael A., Doghramji, Laurel, Douglas, Jennifer E., Maina, Ivy W., Palmer, James N., Adappa, Nithin D., Reed, Danielle R., and Cohen, Noam A.

Published
2021
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8. Tissue-dependent expression of bitter receptor TAS2R38 mRNA

Author

Douglas, Jennifer E, primary, Lin, Cailu, additional, Mansfield, Corrine J, additional, Arayata, Charles J, additional, Cowart, Beverly J, additional, Spielman, Andrew I, additional, Adappa, Nithin D, additional, Palmer, James N, additional, Cohen, Noam A, additional, and Reed, Danielle R, additional

Published
2018
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9. Taste Exam: A Brief and Validated Test

Author

Douglas, Jennifer E., primary, Mansfield, Corrine J., primary, Arayata, Charles J., primary, Cowart, Beverly J., primary, Colquitt, Lauren R., primary, Maina, Ivy W., primary, Blasetti, Mariel T., primary, Cohen, Noam A., primary, and Reed, Danielle R., primary

Published
2018
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10. Dual requirements for WNT10A in proliferation and KLF4-mediated differentiation underlie ectodermal dysplasia

Author

Zu, Mingang, Horrell, Jeremy, Snitow, Melinda, Cui, Jiawei, Gochnauer, Heather, Syrett, Camille M., Kallish, Staci, Seykora, John T., Liu, Fei, Gaillard, Dany, Katz, Jonathan P., Kaestner, Klaus H., Levin, Brooke, Mansfield, Corinne, Douglas, Jennifer E., Cowart, Beverly J., Tordoff, Michael, Liu, Fang, Zhu, Xuming, Barlow, Linda A., Rubin, Adam I., McGrath, John A., Morrisey, Edward E., Chu, Emily Y., and Millar, Sarah E.

Abstract

Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of a broad range of ectodermal defects. Here we show that β-catenin pathway activity and adult epithelial progenitor proliferation are reduced in the absence of WNT10A, and identify Wnt-active self-renewing stem cells in affected tissues including hair follicles, sebaceous glands, taste buds, nails and sweat ducts. Human and mouse WNT10A mutant palmoplantar and tongue epithelia also display specific differentiation defects that are mimicked by loss of the transcription factor KLF4. We find that β-catenin interacts directly with region-specific LEF/TCF factors, and with KLF4 in differentiating, but not proliferating, cells to promote expression of specialized keratins required for normal tissue structure and integrity. Our data identify WNT10A as a critical ligand controlling adult epithelial proliferation and region-specific differentiation, and suggest downstream β-catenin pathway activation as a potential approach to ameliorate regenerative defects in WNT10A patients.

Published
2017

11. Tissue dependent expression of bitter receptorTAS2R38mRNA

Author

Douglas, Jennifer E., primary, Lin, Cailu, additional, Mansfield, Corrine J., additional, Arayata, Charles J., additional, Cowart, Beverly J., additional, Spielman, Andrew I., additional, Adappa, Nithin D., additional, Palmer, James N., additional, Reed, Danielle R., additional, and Cohen, Noam A., additional

Published
2018
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12. The Role of Quinine-Responsive Taste Receptor Family 2 in Airway Immune Defense and Chronic Rhinosinusitis

Author

Workman, Alan D., primary, Maina, Ivy W., additional, Brooks, Steven G., additional, Kohanski, Michael A., additional, Cowart, Beverly J., additional, Mansfield, Corrine, additional, Kennedy, David W., additional, Palmer, James N., additional, Adappa, Nithin D., additional, Reed, Danielle R., additional, Lee, Robert J., additional, and Cohen, Noam A., additional

Published
2018
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14. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation

Author

Xu, Mingang, primary, Horrell, Jeremy, additional, Snitow, Melinda, additional, Cui, Jiawei, additional, Gochnauer, Heather, additional, Syrett, Camille M., additional, Kallish, Staci, additional, Seykora, John T., additional, Liu, Fei, additional, Gaillard, Dany, additional, Katz, Jonathan P., additional, Kaestner, Klaus H., additional, Levin, Brooke, additional, Mansfield, Corinne, additional, Douglas, Jennifer E., additional, Cowart, Beverly J., additional, Tordoff, Michael, additional, Liu, Fang, additional, Zhu, Xuming, additional, Barlow, Linda A., additional, Rubin, Adam I., additional, McGrath, John A., additional, Morrisey, Edward E., additional, Chu, Emily Y., additional, and Millar, Sarah E., additional

Published
2017
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15. Roundtable Proceedings

Author

Kleinman, Ronald E., primary, Greer, Frank, additional, Cowart, Beverly J., additional, Hetherington, Marion M., additional, Johnson, Susan L., additional, Keller, Kathleen L., additional, Klurfeld, David M., additional, Moshfegh, Alanna J., additional, Murray, Robert, additional, Welsh, Jean, additional, Coletta, Frances A., additional, and Marr, Liz, additional

Published
2017
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16. Tissue-Dependent Expression of Bitter Receptor TAS2R38 mRNA.

Author

Douglas, Jennifer E, Lin, Cailu, Mansfield, Corrine J, Arayata, Charles J, Cowart, Beverly J, Spielman, Andrew I, Adappa, Nithin D, Palmer, James N, Cohen, Noam A, and Reed, Danielle R

Abstract

TAS2R38 is a human bitter receptor gene with a common but inactive allele; people homozygous for the inactive form cannot perceive low concentrations of certain bitter compounds. The frequency of the inactive and active forms of this receptor is nearly equal in many human populations, and heterozygotes with 1 copy of the active form and 1 copy of the inactive form have the most common diplotype. However, even though they have the same genotype, heterozygotes differ markedly in their perception of bitterness, perhaps in part because of differences in TAS2R38 mRNA expression. Other tissues express this receptor too, including the nasal sinuses, where it contributes to pathogen defense. We, therefore, wondered whether heterozygous people had a similar wide range of TAS2R38 mRNA in sinonasal tissue and whether those with higher TAS2R38 mRNA expression in taste tissue were similarly high expressers in nasal tissue. To that end, we measured gene expression by quantitative PCR in taste and sinonasal tissue and found that expression abundance in one tissue was not related to the other. We confirmed the independence of expression in other tissue pairs expressing TAS2R38 mRNA, such as pancreas and small intestine, using autopsy data from the Genotype-Tissue Expression project (although people with high expression of TAS2R38 mRNA in colon also tended to have higher expression in the small intestine). Thus, taste tissue TAS2R38 mRNA expression among heterozygotes is unlikely to predict expression in other tissues, perhaps reflecting tissue-dependent function, and hence regulation, of this protein. [ABSTRACT FROM AUTHOR]

Published
2019
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18. TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis

Author

Adappa, Nithin D., primary, Farquhar, Douglas, additional, Palmer, James N., additional, Kennedy, David W., additional, Doghramji, Laurel, additional, Morris, Shane A., additional, Owens, David, additional, Mansfield, Corrine, additional, Lysenko, Anna, additional, Lee, Robert J., additional, Cowart, Beverly J., additional, Reed, Danielle R., additional, and Cohen, Noam A., additional

Published
2015
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19. Nasal Structural and Aerodynamic Features That May Benefit Normal Olfactory Sensitivity.

Author

Chengyu Li, Jianbo Jiang, Kanghyun Kim, Otto, Bradley A., Farag, Alexander A., Cowart, Beverly J., Pribitkin, Edmund A., Dalton, Pamela, and Kai Zhao

Abstract

Nasal airflow that effectively transports ambient odors to the olfactory receptors is important for human olfaction. Yet, the impact of nasal anatomical variations on airflow pattern and olfactory function is not fully understood. In this study, 22 healthy volunteers were recruited and underwent computed tomographic scans for computational simulations of nasal airflow patterns. Unilateral odor detection thresholds (ODT) to l-carvone, phenylethyl alcohol (PEA) and d-limonene were also obtained for all participants. Significant normative variations in both nasal anatomy and aerodynamics were found. The most prominent was the formation of an anterior dorsal airflow vortex in some but not all subjects, with the vortex size being significantly correlated with ODT of l-carvone (r = 0.31, P < 0.05). The formation of the vortex is likely the result of anterior nasal morphology, with the vortex size varying significantly with the nasal index (ratio of the width and height of external nose, r = -0.59, P < 0.001) and nasal vestibule "notch" index (r = 0.76, P < 0.001). The "notch" is a narrowing of the upper nasal vestibule cartilage region. The degree of the notch also significantly correlates with ODT for PEA (r = 0.32, P < 0.05) and l-carvone (r = 0.33, P < 0.05). ODT of d-limonene, a low mucosal soluble odor, does not correlate with any of the anatomical or aerodynamic variables. The current study revealed that nasal anatomy and aerodynamics might have a significant impact on normal olfactory sensitivity, with greater airflow vortex and a narrower vestibule region likely intensifying the airflow vortex toward the olfactory region and resulting in greater olfactory sensitivity to high mucosal soluble odors. [ABSTRACT FROM AUTHOR]

Published
2018
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