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Your search keyword '"D'Souza, Daniel M"' showing total 6 results
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6 results on '"D'Souza, Daniel M"'

1. Recurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome

Author

Berardi, Giammauro, Cucchetti, Alessandro, Sposito, Carlo, Ratti, Francesca, Nebbia, Martina, D’Souza, Daniel M., Pascual, Franco, Dogeas, Epameinondas, Tohme, Samer, Vitale, Alessandro, D’Amico, Francesco Enrico, Alessandris, Remo, Panetta, Valentina, Simonelli, Ilaria, Colasanti, Marco, Russolillo, Nadia, Moro, Amika, Fiorentini, Guido, Serenari, Matteo, Rotellar, Fernando, Zimitti, Giuseppe, Famularo, Simone, Ivanics, Tommy, Donando, Felipe Gaviria, Hoffman, Daniel, Onkendi, Edwin, Essaji, Yasmin, Giuliani, Tommaso, Lopez Ben, Santiago, Caula, Celia, Rompianesi, Gianluca, Chopra, Asmita, Abu Hilal, Mohammed, Sapisochin, Gonzalo, Torzilli, Guido, Corvera, Carlos, Alseidi, Adnan, Helton, Scott, Troisi, Roberto I., Simo, Kerri, Conrad, Claudius, Cescon, Matteo, Cleary, Sean, Kwon, David Choon Hyuck, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cillo, Umberto, Geller, David, Cherqui, Daniel, Serrano, Pablo E., Ferrone, Cristina, Aldrighetti, Luca, Kingham, T. Peter, and Mazzaferro, Vincenzo

Published
2024
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2. Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome

Author

Berardi, Giammauro, Ivanics, Tommy, Sapisochin, Gonzalo, Ratti, Francesca, Sposito, Carlo, Nebbia, Martina, D’Souza, Daniel M., Pascual, Franco, Tohme, Samer, D’Amico, Francesco Enrico, Alessandris, Remo, Panetta, Valentina, Simonelli, Ilaria, Del Basso, Celeste, Russolillo, Nadia, Fiorentini, Guido, Serenari, Matteo, Rotellar, Fernando, Zimitti, Giuseppe, Famularo, Simone, Hoffman, Daniel, Onkendi, Edwin, Lopez-Ben, Santiago, Caula, Celia, Rompianesi, Gianluca, Chopra, Asmita, Abu Hilal, Mohammed, Torzilli, Guido, Corvera, Carlos, Alseidi, Adnan, Helton, Scott, Troisi, Roberto I., Simo, Kerri, Conrad, Claudius, Cescon, Matteo, Cleary, Sean, Kwon, Choon H. D., Ferrero, Alessandro, Ettorre, Giuseppe M., Cillo, Umberto, Geller, David, Cherqui, Daniel, Serrano, Pablo E., Ferrone, Cristina, Mazzaferro, Vincenzo, Aldrighetti, Luca, and Kingham, T. Peter

Published
2023
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3. Model to predict major complications following liver resection for HCC in patients with metabolic syndrome

Author

Berardi, Giammauro, primary, Ratti, Francesca, additional, Sposito, Carlo, additional, Nebbia, Martina, additional, D’Souza, Daniel M., additional, Pascual, Franco, additional, Dogeas, Epameinondas, additional, Tohme, Samer, additional, D’Amico, Francesco E., additional, Alessandris, Remo, additional, Simonelli, Ilaria, additional, Del Basso, Celeste, additional, Russolillo, Nadia, additional, Moro, Amika, additional, Fiorentini, Guido, additional, Serenari, Matteo, additional, Rotellar, Fernando, additional, Zimmitti, Giuseppe, additional, Famularo, Simone, additional, Ivanics, Tommy, additional, Hoffman, Daniel, additional, Onkendi, Edwin, additional, Essaji, Yasmin, additional, Lopez Ben, Santiago, additional, Caula, Celia, additional, Rompianesi, Gianluca, additional, Chopra, Asmita, additional, Abu Hilal, Mohammed, additional, Torzilli, Guido, additional, Sapisochin, Gonzalo, additional, Corvera, Carlos, additional, Alseidi, Adnan, additional, Helton, Scott, additional, Troisi, Roberto I., additional, Simo, Kerri, additional, Conrad, Claudius, additional, Cescon, Matteo, additional, Cleary, Sean, additional, Kwon, Choon H.D., additional, Ferrero, Alessandro, additional, Ettorre, Giuseppe M., additional, Cillo, Umberto, additional, Geller, David, additional, Cherqui, Daniel, additional, Serrano, Pablo E., additional, Ferrone, Cristina, additional, Mazzaferro, Vincenzo, additional, Aldrighetti, Luca, additional, and Kingham, T. Peter, additional

Published
2023
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5. Model to predict major complications following liver resection for HCC in patients with metabolic syndrome

Author

Giammauro Berardi, Francesca Ratti, Carlo Sposito, Martina Nebbia, Daniel M. D’Souza, Franco Pascual, Epameinondas Dogeas, Samer Tohme, Francesco E. D’Amico, Remo Alessandris, Ilaria Simonelli, Celeste Del Basso, Nadia Russolillo, Amika Moro, Guido Fiorentini, Matteo Serenari, Fernando Rotellar, Giuseppe Zimmitti, Simone Famularo, Tommy Ivanics, Daniel Hoffman, Edwin Onkendi, Yasmin Essaji, Santiago Lopez Ben, Celia Caula, Gianluca Rompianesi, Asmita Chopra, Mohammed Abu Hilal, Guido Torzilli, Gonzalo Sapisochin, Carlos Corvera, Adnan Alseidi, Scott Helton, Roberto I. Troisi, Kerri Simo, Claudius Conrad, Matteo Cescon, Sean Cleary, Choon H.D. Kwon, Alessandro Ferrero, Giuseppe M. Ettorre, Umberto Cillo, David Geller, Daniel Cherqui, Pablo E. Serrano, Cristina Ferrone, Vincenzo Mazzaferro, Luca Aldrighetti, T. Peter Kingham, Berardi, Giammauro, Ratti, Francesca, Sposito, Carlo, Nebbia, Martina, D'Souza, Daniel M, Pascual, Franco, Dogeas, Epameinonda, Tohme, Samer, D'Amico, Francesco E, Alessandris, Remo, Simonelli, Ilaria, Del Basso, Celeste, Russolillo, Nadia, Moro, Amika, Fiorentini, Guido, Serenari, Matteo, Rotellar, Fernando, Zimmitti, Giuseppe, Famularo, Simone, Ivanics, Tommy, Hoffman, Daniel, Onkendi, Edwin, Essaji, Yasmin, Lopez Ben, Santiago, Caula, Celia, Rompianesi, Gianluca, Chopra, Asmita, Abu Hilal, Mohammed, Torzilli, Guido, Sapisochin, Gonzalo, Corvera, Carlo, Alseidi, Adnan, Helton, Scott, Troisi, Roberto I, Simo, Kerri, Conrad, Claudiu, Cescon, Matteo, Cleary, Sean, Kwon, Choon H D, Ferrero, Alessandro, Ettorre, Giuseppe M, Cillo, Umberto, Geller, David, Cherqui, Daniel, Serrano, Pablo E, Ferrone, Cristina, Mazzaferro, Vincenzo, Aldrighetti, Luca, and Kingham, T Peter

Subjects
Hepatology
Abstract

Background: Metabolic syndrome (MS) is rapidly growing as risk factor for HCC. Liver resection for HCC in patients with MS is associated with increased postoperative risks. There are no data on factors associated with postoperative complications. Aims: The aim was to identify risk factors and develop and validate a model for postoperative major morbidity after liver resection for HCC in patients with MS, using a large multicentric Western cohort. Materials and methods: The univariable logistic regression analysis was applied to select predictive factors for 90 days major morbidity. The model was built on the multivariable regression and presented as a nomogram. Performance was evaluated by internal validation through the bootstrap method. The predictive discrimination was assessed through the concordance index. Results: A total of 1087 patients were gathered from 24 centers between 2001 and 2021. Four hundred and eighty-four patients (45.2%) were obese. Most liver resections were performed using an open approach (59.1%), and 743 (68.3%) underwent minor hepatectomies. Three hundred and seventy-six patients (34.6%) developed postoperative complications, with 13.8% major morbidity and 2.9% mortality rates. Seven hundred and thirteen patients had complete data and were included in the prediction model. The model identified obesity, diabetes, ischemic heart disease, portal hypertension, open approach, major hepatectomy, and changes in the nontumoral parenchyma as risk factors for major morbidity. The model demonstrated an AUC of 72.8% (95% CI: 67.2%-78.2%) (https://childb.shinyapps.io/NomogramMajorMorbidity90days/). Conclusions: Patients undergoing liver resection for HCC and MS are at high risk of postoperative major complications and death. Careful patient selection, considering baseline characteristics, liver function, and type of surgery, is key to achieving optimal outcomes.

Published
2023

6. Domino Insertion-Coupling Synthesis of Solid-State Luminescent Propynylidene Indolones.

Author

Schönhaber J, D'Souza DM, Glißmann T, Mayer B, Janiak C, Rominger F, Frank W, and Müller TJJ

Abstract

The compound class of 3-arylpropynylidene indolones, key intermediates in consecutive three-component syntheses of various indole-based chromophores with peculiar emission characteristics, are readily synthesized by a domino insertion-coupling synthesis with an electronically diverse substitution pattern in moderate to excellent yields. The title compounds are formed in E/Z-ratios from 100:0 to 0:100. Besides structure elucidation by NMR-spectroscopy and X-ray structure analysis, DFT calculations have been employed to rationalize the observed stereoselectivity. The photophysical properties of 3-arylpropynylidene indolones are characterized by intense, tunable, solid-state emission of N-substituted derivatives as quantified for drop-cast films. The electronic ground state structure was corroborated by DFT and TD-DFT calculations, showing that gradient-corrected exchange and correlation PBE (Perdew-Burke-Ernzerhof) functionals can be successfully employed to correctly reproduce the observed absorption characteristics of merocyanine derivatives. The huge Stokes shifts strongly depend on the electronic substitution pattern as supported by Hammett-Taft correlations., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2018
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