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Your search keyword '"Dai, Zhenlin"' showing total 19 results
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19 results on '"Dai, Zhenlin"'

7. Head‐and‐neck dermatofibrosarcoma protuberans: Survival analysis and Clinically relevant immunohistochemical indicators.

Author

Dai, Zhenlin, He, Youya, Zhang, Xu, Tian, Zhen, Zhu, Guopei, Ren, Zhenhu, Ye, Lulu, Liu, Zheqi, Ma, Chunyue, Cao, Wei, and Ji, Tong

Subjects
*HEAD & neck cancer treatment, *CLINICAL medicine, *RESEARCH funding, *HEAD & neck cancer, *KEY performance indicators (Management), *MEDICAL care, *FISHER exact test, *SYMPTOMS, *DESCRIPTIVE statistics, *CHI-squared test, *IMMUNOHISTOCHEMISTRY, *KAPLAN-Meier estimator, *LOG-rank test, *QUALITY assurance, *DATA analysis software, *SURVIVAL analysis (Biometry), CONNECTIVE tissue tumors
Abstract

Background: Head and neck dermatofibrosarcoma protuberans (HNDFSP) is extremely rare and not entirely understood. Objective: To investigate the clinicopathological features of HNDFSP and identify the expression of its clinically relevant indicators, with the expectation of improving the existing treatment strategies. Methods: A long‐term follow‐up of patients with HNDFSP who received treatment between 2000 and 2021 at Shanghai Ninth People's Hospital was conducted. The clinical, histological, and immunohistochemical data of the patients were retrieved and analyzed. The endpoint of the study was the incidence of significant disease‐related clinical events (recurrences or metastasis). Results: A total of 49 patients with HNDFSP were included in the study, with males (92.7%) predominating than females (7.3%). Eighteen patients developed recurrent disease (36.8%) after surgery, and the median time of recurrence was 48 months (interquartile, 20–74 months). Metastasis occurred in two cases (4.1%). Two patients died during follow‐up, both with local recurrence, and one of them with intestinal metastasis. Post‐operation radiotherapy was administered to eight patients (16.3%) and the effect in local control was remarkable. Age, tumor size, and negative margins with sufficient safety width were the main independent factors affecting the disease‐free survival. Several potential targeted therapeutic indicators, including EZH2 (80.0%), EGFR (91.4%), PDGF (97.1%), PD‐L1 (77.1%), and VEGF (77.1%), were positively expressed in most tumor samples. Conclusion: HNDFSP is rare, significantly challenging to control locally, and has a worse prognosis with current treatment strategies. Wide local excision and long‐term follow‐up are needed. Radiotherapy could improve the prognosis of patients with HNDFSP. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Nerve growth factor (NGF)-TrkA axis in head and neck squamous cell carcinoma triggers EMT and confers resistance to the EGFR inhibitor erlotinib

Author

Lin, Chengzhong, primary, Ren, Zhenhu, additional, Yang, Xi, additional, Yang, Rong, additional, Chen, Yiming, additional, Liu, Zheqi, additional, Dai, Zhenlin, additional, Zhang, Yu, additional, He, Youya, additional, Zhang, Chunye, additional, Wang, Xu, additional, Cao, Wei, additional, and Ji, Tong, additional

Published
2020
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19. Insights into the relevance between bacterial endophytic communities and resistance of rice cultivars infected by Xanthomonas oryzaepv. oryzicola

Author

Yang, Jun, Dai, Zhenlin, Wan, Xiaoyan, Munir, Shahzad, Wang, Xing, Wei, Lanfang, and Ji, Guanghai

Abstract

Bacterial leaf streak (BLS) caused by Xanthomonas oryzaepv. oryzicola(Xoc), impacts the production of rice. However, several rice cultivars displayed resistance to Xocin the field, but scarce information is available about the role of endophytic microbiota in disease resistance. In the present study, the endophytic bacterial communities of resistant and susceptible rice cultivars “CG2” and “IR24”, respectively, were analyzed using high throughput 16S rRNAgene amplified sequencing and culture dependent method was further used for bacterial isolation. A total of 452,716 high-quality sequences representing 132 distinct OTUs (Proteobacteria, Actinobacteria, Bacteroidetes, and Firmicutes) and 46 isolates of 16 genera were explored from rice leaves infected with Xoc. Community diversity of endophytic bacteria were higher in the leaves of the resistant cultivars compared to susceptible cultivars upon Xocinfection. Strikingly, this diversity might contribute to natural defense of the resistant cultivar against pathogen. Pantoea, which is pathogen antagonist, was frequently detected in two cultivars and higher abundance were recorded in resistant cultivars. Different abundance genus includes endophytic isolates with marked antagonistic activity to Xoc. The increased proportions of antagonistic bacteria, may contribute to resistance of rice cultivar against Xocand the Pantoeagenus was recruited by Xocinfection play a key role in suppressing the development of BLS disease in rice. Taken together, this work reveals the association between endophytic bacteria and BLS resistance in rice and identification of antagonism-Xocbacterial communities in rice.

Published
2021
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