Search

There is limited data on indications and outcomes of home continuous positive airway pressure (CPAP) therapy in the first year of life. We aimed to analyze the clinical, demographic, and polysomnographic (PSG) characteristics of a cohort of children initiated on home CPAP for treatment of sleep disordered breathing (SDB) and as respiratory support in the first year of life.Children started on CPAP in the first year of life at the Queensland Children's Hospital were retrospectively evaluated for clinicaldemographic parameters, underlying diagnoses, respiratory support, airway surgical intervention, PSG results at baseline and on CPAP.Twenty-nine infants [median age (IQR) at CPAP initiation 182 days (126-265.5); 12F] were included. Underlying aetiology included Trisomy 21 (n=6), craniofacial syndromes (n=5), hypotonia (n=8; 5 with non-craniofacial syndrome), airway malacia (n=5), skeletal dysplasia (n=2), non-syndromic upper airway obstruction (n=2) and CNLD (n=1). The median (IQR) Obstructive Apnoea-Hypopnea Index was 14\hr (6.2-31) at CPAP initiation, which improved on CPAP to 3.4\hr (1.4-6.4). Median (IQR) TcCOHome CPAP as respiratory support is an effective long-term therapy in infancy and can be weaned even if initiated early. Prospective studies with pre-defined criteria for CPAP initiation and cessation would help ascertain long term outcomes in this poorly researched group.