7 results on '"Del Giudice, E. Miraglia"'
Search Results
2. The impact of the CB2-63 polymorphism on the histological presentation of chronic hepatitis B
- Author
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Coppola, N., primary, Zampino, R., additional, Bellini, G., additional, Stanzione, M., additional, Capoluongo, N., additional, Marrone, A., additional, Macera, M., additional, Pasquale, G., additional, Boemio, A., additional, Maione, S., additional, Adinolfi, L.E., additional, Del Giudice, E. Miraglia, additional, Sagnelli, E., additional, and Rossi, F., additional
- Published
- 2015
- Full Text
- View/download PDF
3. Patients affected by dent disease 2 could be predisposed to hidradenitis suppurativa.
- Author
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Marzuillo, P., Piccolo, V., Mascolo, M., Apicella, A., Argenziano, G., Vecchia, N. Della, Guarino, S., del Giudice, E. Miraglia, and La Manna, A.
- Subjects
HIDRADENITIS suppurativa ,SKIN diseases ,TISSUE wounds ,ABSCESSES ,HAIR follicles ,PATIENTS - Abstract
The article presents a study which shows that patients affected by dent disease 2 could be predisposed to hidradenitis suppurativa (HS). Topics include the lesions started as ‘blind' deep inflammatory nodules and subsequently developed into abscesses, and the primum movens in the HS pathophysiological mechanism is stated to be occlusion followed by inflammation of the hair follicle.
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- 2018
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4. Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation
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Rossi, F., Bellini, G., Luongo, L., Manzo, I., Tolone, S., Tortora, C., Bernardo, M. E., Grandone, A., Conforti, A., Docimo, L., Nobili, B., Perrone, L., Locatelli, F., Maione, S., and del Giudice, E. Miraglia
- Abstract
Context:Obesity is associated with a low-grade inflammatory state and adipocyte (ADP) hyperplasia/hypertrophy. Obesity inhibits the “browning” of white adipose tissue. Cannabinoid receptor 2 (CB2) agonists reduce food intake and induce antiobesity effect in mice. A common missense CB2 variant, Q63R, causes CB2-reduced function.Objective:To evaluate the influence of CB2 receptor on the modulation of childhood obesity and of ADP activity and morphology.Design:CB2-Q63R variant was analyzed in obese Italian children. The effects of an inflammatory stimulus and those of drugs selectively acting on CB2 were investigated on in vitro ADPs obtained from mesenchymal stem cells of adult healthy donors or from sc adipose biopsies of adult nonobese and obese subjects.Setting:Department of Women, Child and General and Specialist Surgery of the Second University of Naples.Patients or Other Participants:A total of 501 obese Italian children (age 11 ± 2.75). Twelve healthy bone marrow donors (age 36.5 ± 15); and 17 subjects, 7 lean (age 42 ± 10) and 10 obese (age 37.8 ± 12) underwent sc adipose tissue biopsies.Main Outcome Measures:Effects of CB2 stimulation on adipokine, perilipin, and uncoupling protein-1 expression.Results:The less-functional CB2-R63 variant was significantly associated with a high z-score body mass index. CB2 blockade with AM630 reverse agonist increased inflammatory adipokine release and fat storage and reduced browning. CB2 stimulation with JWH-133 agonist reversed all of the obesity-related effects.Conclusion:CB2 receptor is a novel pharmacological target that should be considered for obesity.
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- 2016
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5. Phenotypes of prediabetes and metabolic risk in Caucasian youths with overweight or obesity
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P. Di Bonito, M. R. Licenziati, D. Corica, M. G. Wasniewska, A. Di Sessa, E. Miraglia del Giudice, A. Morandi, C. Maffeis, M. F. Faienza, E. Mozzillo, V. Calcaterra, F. Franco, G. Maltoni, G. Valerio, Di Bonito, P., Licenziati, M. R., Corica, D., Wasniewska, M. G., Di Sessa, A., del Giudice, E. M., Morandi, A., Maffeis, C., Faienza, M. F., Mozzillo, E., Calcaterra, V., Franco, F., Maltoni, G., Valerio, G., Di Bonito, P, Licenziati, M R, Corica, D, Wasniewska, M G, Di Sessa, A, Del Giudice, E Miraglia, Morandi, A, Maffeis, C, Faienza, M F, Mozzillo, E, Calcaterra, V, Franco, F, Maltoni, G, and Valerio, G
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Blood Glucose ,Glycated Hemoglobin ,Cardiometabolic risk factor ,HbA1c ,Endocrinology, Diabetes and Metabolism ,Impaired glucose tolerance ,Pediatric obesity ,Fasting ,Glucose Tolerance Test ,Overweight ,Cardiometabolic risk factors ,Impaired fasting glucose ,Prediabetic State ,Prediabetes ,Cross-Sectional Studies ,Phenotype ,Endocrinology ,Glucose Intolerance ,Humans ,Insulin ,Obesity ,Insulin Resistance - Abstract
Purpose To assess the prevalence of pre-diabetes phenotypes, i.e., impaired fasting glucose (IFG), impaired glucose tolerance (IGT), increased HbA1c (IA1c), and their association with metabolic profile and atherogenic lipid profile in youths with overweight/obesity (OW/OB). Methods This cross-sectional study analyzed data of 1549 youths (5–18 years) with OW/OB followed in nine Italian centers between 2016 and 2020. Fasting and post-load measurements of glucose, insulin, and HbA1c were available. Insulin resistance (IR) was estimated by HOMA-IR and insulin sensitivity (IS) by reciprocal of fasting insulin. The atherogenic lipid profile was assessed by triglycerides-to-HDL ratio or cholesterol-to-HDL ratio. Insulinogenic index was available in 939 youths, in whom the disposition index was calculated. Results The prevalence of overall pre-diabetes, IFG, IGT and IA1c was 27.6%, 10.2%, 8% and 16.3%, respectively. Analyzing each isolated phenotype, IGT exhibited two- to three-fold higher odds ratio of family history of diabetes, and worse metabolic and atherogenic lipid profile vs normoglycemic youths; IFG was associated only with IR, while IA1c showed a metabolic and atherogenic lipid profile intermediate between IGT and IFG. Conclusion Prevalence of pre-diabetes was high and IA1c was the most prevalent phenotype in Italian youths with OW/OB. The IGT phenotype showed the worst metabolic and atherogenic lipid profile, followed by IA1c. More studies are needed to assess whether HbA1c may help improving the prediction of diabetes.
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- 2022
6. Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians
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Irene Cetin, Giuseppe Di Mauro, Francesco Vierucci, Rino Agostiniani, Daniele Giovanni Ghiglioni, Fabio Cardinale, Domenico Careddu, Flavia Prodam, Diego Peroni, Luigi Terracciano, Giuseppe Saggese, Elena Chiappini, Giovanni Corsello, Michele Miraglia Del Giudice, Maddalena Massari, Gian Luigi De' Angelis, Emanuele Miraglia del Giudice, Gianni Bona, Saggese, Giuseppe, Vierucci, Francesco, Prodam, Flavia, Cardinale, Fabio, Cetin, Irene, Chiappini, Elena, De Angelis, Gian Luigi, Massari, Maddalena, Miraglia Del Giudice, Emanuele, Miraglia Del Giudice, Michele, Peroni, Diego, Terracciano, Luigi, Agostiniani, Rino, Careddu, Domenico, Ghiglioni, Daniele Giovanni, Bona, Gianni, Di Mauro, Giuseppe, Corsello, Giovanni, and Saggese G, Vierucci F, Prodam F, Cardinale F, Cetin I, Chiappini E, De' Angelis GL, Massari M, Miraglia Del Giudice E, Miraglia Del Giudice M, Peroni D, Terracciano L, Agostiniani R, Careddu D, Ghiglioni DG, Bona G, Di Mauro G, Corsello G
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Pediatrics ,medicine.medical_specialty ,Consensus ,Adolescent ,Supplementation ,Consensu ,030209 endocrinology & metabolism ,Review ,Adolescents ,Vitamin ,vitamin D deficiency ,law.invention ,Nutritional Rickets ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,030225 pediatrics ,Vitamin D and neurology ,medicine ,Musculoskeletal health ,Humans ,Vitamin D ,Child ,Pathological ,Children ,Societies, Medical ,Dietary Supplement ,vitamin D children ,Vitamin d supplementation ,business.industry ,lcsh:RJ1-570 ,Infant, Newborn ,Infant ,Hypovitaminosis D ,lcsh:Pediatrics ,Pediatric age ,General Medicine ,Vitamins ,medicine.disease ,Vitamin D Deficiency ,Italy ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Dietary Supplements ,Deficiency ,business ,Human - Abstract
Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur. Besides its historical skeletal functions, in the last years it has been demonstrated that vitamin D directly or indirectly regulates up to 1250 genes, playing so-called extraskeletal actions. Indeed, recent data suggest a possible role of vitamin D in the pathogenesis of several pathological conditions, including infectious, allergic and autoimmune diseases. Thus, vitamin D deficiency may affect not only musculoskeletal health but also a potentially wide range of acute and chronic conditions. At present, the prevalence of vitamin D deficiency is high in Italian children and adolescents, and national recommendations on vitamin D supplementation during pediatric age are lacking. An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplementation to provide a practical approach to vitamin D supplementation for infants, children and adolescents.
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- 2017
7. Association between cannabinoid receptor type 2 Q63R variant and oligo/polyarticular juvenile idiopathic arthritis.
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Bellini G, Olivieri AN, Grandone A, Alessio M, Gicchino MF, Nobili B, Perrone L, Maione S, del Giudice EM, and Rossi F
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- Arthritis ethnology, Arthritis, Juvenile ethnology, Case-Control Studies, Child, Child, Preschool, Female, Genetic Predisposition to Disease ethnology, Genetic Predisposition to Disease genetics, Genotype, Humans, Italy, Male, Severity of Illness Index, Arthritis genetics, Arthritis, Juvenile genetics, Genetic Variation genetics, Receptor, Cannabinoid, CB2 genetics
- Abstract
Objectives: To investigate whether the functional variant Q63R of the cannabinoid 2 (CB2) receptor is associated with susceptibility to oligo/poly-articular juvenile idiopathic arthritis (JIA) and with its clinical features., Method: A total of 171 Italian children with oligoarticular/rheumatoid factor negative poly-articular JIA and 600 healthy controls were enrolled in the study and genotyped., Results: A significant difference in genotype distribution of the CB2 Q63R variant (CNR2 rs35761398) between oligo/poly-articular JIA patients and controls was found (p = 0.001). The R63 variant was associated with increased rates of relapse (p = 0.0001)., Conclusions: This study indicates that the CB2 receptor contributes to susceptibility to oligo/polyarticular JIA and to the severity of its clinical course.
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- 2015
- Full Text
- View/download PDF
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