125 results on '"Deo N."'
Search Results
2. Benign descriptors and ADNEX in two-step strategy to estimate risk of malignancy in ovarian tumors: retrospective validation on IOTA 5 multicenter cohort
- Author
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Landolfo, C, Bourne, T, Froyman, W, Van Calster, B, Ceusters, J, Testa, A, Wynants, L, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Savelli, L, Fischerova, D, Czekierdowski, A, Kaijser, J, Coosemans, A, Scambia, G, Vergote, I, Timmerman, D, Valentin, L, Landolfo C., Bourne T., Froyman W., Van Calster B., Ceusters J., Testa A. C., Wynants L., Sladkevicius P., Van Holsbeke C., Domali E., Fruscio R., Epstein E., Franchi D., Kudla M. J., Chiappa V., Alcazar J. L., Leone F. P. G., Buonomo F., Coccia M. E., Guerriero S., Deo N., Jokubkiene L., Savelli L., Fischerova D., Czekierdowski A., Kaijser J., Coosemans A., Scambia G., Vergote I., Timmerman D., Valentin L., Landolfo, C, Bourne, T, Froyman, W, Van Calster, B, Ceusters, J, Testa, A, Wynants, L, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Savelli, L, Fischerova, D, Czekierdowski, A, Kaijser, J, Coosemans, A, Scambia, G, Vergote, I, Timmerman, D, Valentin, L, Landolfo C., Bourne T., Froyman W., Van Calster B., Ceusters J., Testa A. C., Wynants L., Sladkevicius P., Van Holsbeke C., Domali E., Fruscio R., Epstein E., Franchi D., Kudla M. J., Chiappa V., Alcazar J. L., Leone F. P. G., Buonomo F., Coccia M. E., Guerriero S., Deo N., Jokubkiene L., Savelli L., Fischerova D., Czekierdowski A., Kaijser J., Coosemans A., Scambia G., Vergote I., Timmerman D., and Valentin L. more...
- Abstract
Objective: Previous work suggested that the ultrasound-based benign Simple Descriptors can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. We aim to validate a modified version of the Benign Simple Descriptors (BD), and we introduce a two-step strategy to estimate the risk of malignancy: if the BDs do not apply, the ADNEX model is used to estimate the risk of malignancy. Methods: This is a retrospective analysis using the data from the 2-year interim analysis of the IOTA5 study, in which consecutive patients with at least one adnexal mass were recruited irrespective of subsequent management (conservative or surgery). The main outcome was classification of tumors as benign or malignant, based on histology or on clinical and ultrasound information during one year of follow-up. Multiple imputation was used when outcome based on follow-up was uncertain according to predefined criteria. Results: 8519 patients were recruited at 36 centers between 2012 and 2015. We included all masses that were not already in follow-up at recruitment from 17 centers with good quality surgical and follow-up data, leaving 4905 patients for statistical analysis. 3441 (70%) tumors were benign, 978 (20%) malignant, and 486 (10%) uncertain. The BDs were applicable in 1798/4905 (37%) tumors, and 1786 (99.3%) of these were benign. The two-step strategy based on ADNEX without CA125 had an area under the receiver operating characteristic curve (AUC) of 0.94 (95% CI, 0.91-0.95). The risk of malignancy was slightly underestimated, but calibration varied between centers. A sensitivity analysis in which we expanded the definition of uncertain outcome resulted in 1419 (29%) tumors with uncertain outcome and an AUC of the two-step strategy without CA125 of 0.93 (95% CI, 0.91-0.95). Conclusion: A large proportion of adnexal masses can be classified as benign by the BDs. For the remaining masses the ADNEX model can be used to estimate the risk of malignancy. This more...
- Published
- 2023
Catalog
3. Primary Retroperitoneal Mucinous Tumours Diagnosed in Pregnancy: A Case Report and Literature Review
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Tahmasebi F, Morje M, Jamall H, Polson A, and Deo N
- Subjects
primary retroperitoneal mucinous adenocarcinoma ,pregnancy ,Gynecology and obstetrics ,RG1-991 - Abstract
Farshad Tahmasebi,1 Mridula Morje,2 Hina Jamall,1 Alexander Polson,3 Nandia Deo1 1Obstetrics and Gynaecology, Whipps Cross University Hospital, London, UK; 2Obstetrics and Gynaecology, St Thomas’ Hospital, London, UK; 3Cellular Pathology, Histopathology, St Thomas’ Hospital, London, UKCorrespondence: Farshad Tahmasebi Flat 20 Charing Cross Mansions, 26 Charing Cross Road, London WC2H 0DG, UKEmail tfarshad@hotmail.comAbstract: We present the case of a pregnant patient who was found to have a primary retroperitoneal mucinous tumour (PMRT). An abdominal mass measuring 11.5 × 9.8 × 8.8cm, initially thought to be of ovarian origin, was found incidentally on ultrasound in a 36-year-old patient at 20 weeks’ gestation. Tumour markers were normal. She underwent an elective Caesarean section at 34 weeks, but the uterus, fallopian tubes and ovaries were normal. The mass was found to be retroperitoneal. A clinical decision was made to avoid further surgical exploration at the time. Following further surgical planning, the patient underwent open resection of the retroperitoneal mass, 6 weeks after her Caesarean section. Histology confirmed a moderately differentiated adenocarcinoma suggestive of a primary retroperitoneal mucinous adenocarcinoma. A literature review following this identified five case reports of PMRT in pregnancy in the last decade. In all cases, the patients underwent tumour resection without adverse pregnancy outcomes. While our patient had an uncomplicated pregnancy, she developed a 2cm lesion suggestive of disease recurrence 15 months post-operatively. A plan was made for surgical resection. PMRT are rare, but can occur in pregnant patients and patients of childbearing age. Tumour resection should be carried out, but where there is no concrete evidence of tumour invasion, the uterus and ovaries should be spared to avoid infertility and menopause. We would recommend early tumour resection, given its potentially aggressive nature.Keywords: primary retroperitoneal mucinous adenocarcinoma, pregnancy more...
- Published
- 2019
4. External Validation of the Ovarian-Adnexal Reporting and Data System (O-RADS) Lexicon and the International Ovarian Tumor Analysis 2-Step Strategy to Stratify Ovarian Tumors into O-RADS Risk Groups
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Timmerman, S. Valentin, L. Ceusters, J. Testa, A.C. Landolfo, C. Sladkevicius, P. Van Holsbeke, C. Domali, E. Fruscio, R. Epstein, E. Franchi, D. Kudla, M.J. Chiappa, V. Alcazar, J.L. Leone, F.P.G. Buonomo, F. Coccia, M.E. Guerriero, S. Deo, N. Jokubkiene, L. Kaijser, J. Scambia, G. Andreotti, R. Timmerman, D. Bourne, T. Van Calster, B. Froyman, W. and Timmerman, S. Valentin, L. Ceusters, J. Testa, A.C. Landolfo, C. Sladkevicius, P. Van Holsbeke, C. Domali, E. Fruscio, R. Epstein, E. Franchi, D. Kudla, M.J. Chiappa, V. Alcazar, J.L. Leone, F.P.G. Buonomo, F. Coccia, M.E. Guerriero, S. Deo, N. Jokubkiene, L. Kaijser, J. Scambia, G. Andreotti, R. Timmerman, D. Bourne, T. Van Calster, B. Froyman, W. more...
- Abstract
Importance: Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy. Objective: To investigate the diagnostic performance of the O-RADS lexicon and the IOTA 2-step strategy. Design, Setting, and Participants: Retrospective external diagnostic validation study based on interim data of IOTA5, a prospective international multicenter cohort study, in 36 oncology referral centers or other types of centers. A total of 8519 consecutive adult patients presenting with an adnexal mass between January 1, 2012, and March 1, 2015, and treated either with surgery or conservatively were included in this diagnostic study. Twenty-five patients were excluded for withdrawal of consent, 2777 were excluded from 19 centers that did not meet predefined data quality criteria, and 812 were excluded because they were already in follow-up at recruitment. The analysis included 4905 patients with a newly detected adnexal mass in 17 centers that met predefined data quality criteria. Data were analyzed from January 31 to March 1, 2022. Exposures: Stratification into O-RADS categories (malignancy risk <1%, 1% to <10%, 10% to <50%, and ≥50%). For the IOTA 2-step strategy, the stratification is based on the individual risk of malignancy calculated with the IOTA 2-step strategy. Main Outcomes and Measures: Observed prevalence of malignancy in each O-RADS risk category, as well as sensitivity and specificity. The reference standard was the status of the tumor at inclusion, determined by histology or clinical and ultrasonographic follow-up for 1 year. Multiple imputation was used for uncertain outcomes owing to inconclusive follow-up information. Results: Median age of the 4905 patients was 48 years (IQR, 36-62 years). more...
- Published
- 2023
5. Benign descriptors and ADNEX in two-step strategy to estimate risk of malignancy in ovarian tumors: retrospective validation in IOTA5 multicenter cohort
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Landolfo, C. Bourne, T. Froyman, W. Van Calster, B. Ceusters, J. Testa, A.C. Wynants, L. Sladkevicius, P. Van Holsbeke, C. Domali, E. Fruscio, R. Epstein, E. Franchi, D. Kudla, M.J. Chiappa, V. Alcazar, J.L. Leone, F.P.G. Buonomo, F. Coccia, M.E. Guerriero, S. Deo, N. Jokubkiene, L. Savelli, L. Fischerova, D. Czekierdowski, A. Kaijser, J. Coosemans, A. Scambia, G. Vergote, I. Timmerman, D. Valentin, L. and Landolfo, C. Bourne, T. Froyman, W. Van Calster, B. Ceusters, J. Testa, A.C. Wynants, L. Sladkevicius, P. Van Holsbeke, C. Domali, E. Fruscio, R. Epstein, E. Franchi, D. Kudla, M.J. Chiappa, V. Alcazar, J.L. Leone, F.P.G. Buonomo, F. Coccia, M.E. Guerriero, S. Deo, N. Jokubkiene, L. Savelli, L. Fischerova, D. Czekierdowski, A. Kaijser, J. Coosemans, A. Scambia, G. Vergote, I. Timmerman, D. Valentin, L. more...
- Abstract
Objective: Previous work has suggested that the ultrasound-based benign simple descriptors (BDs) can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. This study aimed to validate a modified version of the BDs and to validate a two-step strategy to estimate the risk of malignancy, in which the modified BDs are followed by the Assessment of Different NEoplasias in the adneXa (ADNEX) model if modified BDs do not apply. Methods: This was a retrospective analysis using data from the 2-year interim analysis of the International Ovarian Tumor Analysis (IOTA) Phase-5 study, in which consecutive patients with at least one adnexal mass were recruited irrespective of subsequent management (conservative or surgery). The main outcome was classification of tumors as benign or malignant, based on histology or on clinical and ultrasound information during 1 year of follow-up. Multiple imputation was used when outcome based on follow-up was uncertain according to predefined criteria. Results: A total of 8519 patients were recruited at 36 centers between 2012 and 2015. We excluded patients who were already in follow-up at recruitment and all patients from 19 centers that did not fulfil our criteria for good-quality surgical and follow-up data, leaving 4905 patients across 17 centers for statistical analysis. Overall, 3441 (70%) tumors were benign, 978 (20%) malignant and 486 (10%) uncertain. The modified BDs were applicable in 1798/4905 (37%) tumors, of which 1786 (99.3%) were benign. The two-step strategy based on ADNEX without CA125 had an area under the receiver-operating-characteristics curve (AUC) of 0.94 (95% CI, 0.92–0.96). The risk of malignancy was slightly underestimated, but calibration varied between centers. A sensitivity analysis in which we expanded the definition of uncertain outcome resulted in 1419 (29%) tumors with uncertain outcome and an AUC of the two-step strategy without CA125 of 0.93 (95% CI, 0.91–0.95). Conclusion more...
- Published
- 2023
6. Benign descriptors and ADNEX in two-step strategy to estimate risk of malignancy in ovarian tumors: retrospective validation in IOTA5 multicenter cohort
- Author
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Landolfo, C, Bourne, T, Froyman, W, Van Calster, B, Ceusters, J, Testa, Antonia Carla, Wynants, L, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M J, Chiappa, V, Alcazar, J L, Leone, F P G, Buonomo, F, Coccia, M E, Guerriero, Silvia, Deo, N, Jokubkiene, L, Savelli, L, Fischerova, D, Czekierdowski, A, Kaijser, J, Coosemans, A, Scambia, Giovanni, Vergote, I, Timmerman, D, Valentin, L, Testa, A C (ORCID:0000-0003-2217-8726), Guerriero, S, Scambia, G (ORCID:0000-0003-2758-1063), Landolfo, C, Bourne, T, Froyman, W, Van Calster, B, Ceusters, J, Testa, Antonia Carla, Wynants, L, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M J, Chiappa, V, Alcazar, J L, Leone, F P G, Buonomo, F, Coccia, M E, Guerriero, Silvia, Deo, N, Jokubkiene, L, Savelli, L, Fischerova, D, Czekierdowski, A, Kaijser, J, Coosemans, A, Scambia, Giovanni, Vergote, I, Timmerman, D, Valentin, L, Testa, A C (ORCID:0000-0003-2217-8726), Guerriero, S, and Scambia, G (ORCID:0000-0003-2758-1063) more...
- Abstract
ObjectivePrevious work has suggested that the ultrasound-based benign simple descriptors (BDs) can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. This study aimed to validate a modified version of the BDs and to validate a two-step strategy to estimate the risk of malignancy, in which the modified BDs are followed by the Assessment of Different NEoplasias in the adneXa (ADNEX) model if modified BDs do not apply. MethodsThis was a retrospective analysis using data from the 2-year interim analysis of the International Ovarian Tumor Analysis (IOTA) Phase-5 study, in which consecutive patients with at least one adnexal mass were recruited irrespective of subsequent management (conservative or surgery). The main outcome was classification of tumors as benign or malignant, based on histology or on clinical and ultrasound information during 1 year of follow-up. Multiple imputation was used when outcome based on follow-up was uncertain according to predefined criteria. ResultsA total of 8519 patients were recruited at 36 centers between 2012 and 2015. We excluded patients who were already in follow-up at recruitment and all patients from 19 centers that did not fulfil our criteria for good-quality surgical and follow-up data, leaving 4905 patients across 17 centers for statistical analysis. Overall, 3441 (70%) tumors were benign, 978 (20%) malignant and 486 (10%) uncertain. The modified BDs were applicable in 1798/4905 (37%) tumors, of which 1786 (99.3%) were benign. The two-step strategy based on ADNEX without CA125 had an area under the receiver-operating-characteristics curve (AUC) of 0.94 (95% CI, 0.92-0.96). The risk of malignancy was slightly underestimated, but calibration varied between centers. A sensitivity analysis in which we expanded the definition of uncertain outcome resulted in 1419 (29%) tumors with uncertain outcome and an AUC of the two-step strategy without CA125 of 0.93 (95% CI, 0.91-0.95). ConclusionA large more...
- Published
- 2023
7. External Validation of the Ovarian-Adnexal Reporting and Data System (O-RADS) Lexicon and the International Ovarian Tumor Analysis 2-Step Strategy to Stratify Ovarian Tumors Into O-RADS Risk Groups
- Author
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Timmerman, S, Valentin, L, Ceusters, J, Testa, A, Landolfo, C, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Kaijser, J, Scambia, G, Andreotti, R, Timmerman, D, Bourne, T, Van Calster, B, Froyman, W, Timmerman, Stefan, Valentin, Lil, Ceusters, Jolien, Testa, Antonia C, Landolfo, Chiara, Sladkevicius, Povilas, Van Holsbeke, Caroline, Domali, Ekaterini, Fruscio, Robert, Epstein, Elisabeth, Franchi, Dorella, Kudla, Marek J, Chiappa, Valentina, Alcazar, Juan L, Leone, Francesco P G, Buonomo, Francesca, Coccia, Maria Elisabetta, Guerriero, Stefano, Deo, Nandita, Jokubkiene, Ligita, Kaijser, Jeroen, Scambia, Giovanni, Andreotti, Rochelle, Timmerman, Dirk, Bourne, Tom, Van Calster, Ben, Froyman, Wouter, Timmerman, S, Valentin, L, Ceusters, J, Testa, A, Landolfo, C, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Kaijser, J, Scambia, G, Andreotti, R, Timmerman, D, Bourne, T, Van Calster, B, Froyman, W, Timmerman, Stefan, Valentin, Lil, Ceusters, Jolien, Testa, Antonia C, Landolfo, Chiara, Sladkevicius, Povilas, Van Holsbeke, Caroline, Domali, Ekaterini, Fruscio, Robert, Epstein, Elisabeth, Franchi, Dorella, Kudla, Marek J, Chiappa, Valentina, Alcazar, Juan L, Leone, Francesco P G, Buonomo, Francesca, Coccia, Maria Elisabetta, Guerriero, Stefano, Deo, Nandita, Jokubkiene, Ligita, Kaijser, Jeroen, Scambia, Giovanni, Andreotti, Rochelle, Timmerman, Dirk, Bourne, Tom, Van Calster, Ben, and Froyman, Wouter more...
- Abstract
Importance: Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy. Objective: To investigate the diagnostic performance of the O-RADS lexicon and the IOTA 2-step strategy. Design, Setting, and Participants: Retrospective external diagnostic validation study based on interim data of IOTA5, a prospective international multicenter cohort study, in 36 oncology referral centers or other types of centers. A total of 8519 consecutive adult patients presenting with an adnexal mass between January 1, 2012, and March 1, 2015, and treated either with surgery or conservatively were included in this diagnostic study. Twenty-five patients were excluded for withdrawal of consent, 2777 were excluded from 19 centers that did not meet predefined data quality criteria, and 812 were excluded because they were already in follow-up at recruitment. The analysis included 4905 patients with a newly detected adnexal mass in 17 centers that met predefined data quality criteria. Data were analyzed from January 31 to March 1, 2022. Exposures: Stratification into O-RADS categories (malignancy risk <1%, 1% to <10%, 10% to <50%, and ≥50%). For the IOTA 2-step strategy, the stratification is based on the individual risk of malignancy calculated with the IOTA 2-step strategy. Main Outcomes and Measures: Observed prevalence of malignancy in each O-RADS risk category, as well as sensitivity and specificity. The reference standard was the status of the tumor at inclusion, determined by histology or clinical and ultrasonographic follow-up for 1 year. Multiple imputation was used for uncertain outcomes owing to inconclusive follow-up information. Results: Median age of the 4905 patients was 48 years (IQR, 36-62 years). more...
- Published
- 2023
8. Benign descriptors and ADNEX in two‐step strategy to estimate risk of malignancy in ovarian tumors: retrospective validation in IOTA5 multicenter cohort
- Author
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Landolfo, C., primary, Bourne, T., additional, Froyman, W., additional, Van Calster, B., additional, Ceusters, J., additional, Testa, A. C., additional, Wynants, L., additional, Sladkevicius, P., additional, Van Holsbeke, C., additional, Domali, E., additional, Fruscio, R., additional, Epstein, E., additional, Franchi, D., additional, Kudla, M. J., additional, Chiappa, V., additional, Alcazar, J. L., additional, Leone, F. P. G., additional, Buonomo, F., additional, Coccia, M. E., additional, Guerriero, S., additional, Deo, N., additional, Jokubkiene, L., additional, Savelli, L., additional, Fischerova, D., additional, Czekierdowski, A., additional, Kaijser, J., additional, Coosemans, A., additional, Scambia, G., additional, Vergote, I., additional, Timmerman, D., additional, and Valentin, L., additional more...
- Published
- 2023
- Full Text
- View/download PDF
9. Better approximation results by Bernstein–Kantorovich operators
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Dhamija, M. and Deo, N.
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- 2017
- Full Text
- View/download PDF
10. Validation of models to diagnose ovarian cancer in patients managed surgically or conservatively: multicentre cohort study
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Van Calster, B, Valentin, L, Froyman, W, Landolfo, C, Ceusters, J, Testa, A, Wynants, L, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Savelli, L, Fischerova, D, Czekierdowski, A, Kaijser, J, Coosemans, A, Scambia, G, Vergote, I, Bourne, T, Timmerman, D, Van Calster B., Valentin L., Froyman W., Landolfo C., Ceusters J., Testa A. C., Wynants L., Sladkevicius P., Van Holsbeke C., Domali E., Fruscio R., Epstein E., Franchi D., Kudla M. J., Chiappa V., Alcazar J. L., Leone F. P. G., Buonomo F., Coccia M. E., Guerriero S., Deo N., Jokubkiene L., Savelli L., Fischerova D., Czekierdowski A., Kaijser J., Coosemans A., Scambia G., Vergote I., Bourne T., Timmerman D., Van Calster, B, Valentin, L, Froyman, W, Landolfo, C, Ceusters, J, Testa, A, Wynants, L, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Savelli, L, Fischerova, D, Czekierdowski, A, Kaijser, J, Coosemans, A, Scambia, G, Vergote, I, Bourne, T, Timmerman, D, Van Calster B., Valentin L., Froyman W., Landolfo C., Ceusters J., Testa A. C., Wynants L., Sladkevicius P., Van Holsbeke C., Domali E., Fruscio R., Epstein E., Franchi D., Kudla M. J., Chiappa V., Alcazar J. L., Leone F. P. G., Buonomo F., Coccia M. E., Guerriero S., Deo N., Jokubkiene L., Savelli L., Fischerova D., Czekierdowski A., Kaijser J., Coosemans A., Scambia G., Vergote I., Bourne T., and Timmerman D. more...
- Abstract
OBJECTIVE: To evaluate the performance of diagnostic prediction models for ovarian malignancy in all patients with an ovarian mass managed surgically or conservatively. DESIGN: Multicentre cohort study. SETTING: 36 oncology referral centres (tertiary centres with a specific gynaecological oncology unit) or other types of centre. PARTICIPANTS: Consecutive adult patients presenting with an adnexal mass between January 2012 and March 2015 and managed by surgery or follow-up. MAIN OUTCOME MEASURES: Overall and centre specific discrimination, calibration, and clinical utility of six prediction models for ovarian malignancy (risk of malignancy index (RMI), logistic regression model 2 (LR2), simple rules, simple rules risk model (SRRisk), assessment of different neoplasias in the adnexa (ADNEX) with or without CA125). ADNEX allows the risk of malignancy to be subdivided into risks of a borderline, stage I primary, stage II-IV primary, or secondary metastatic malignancy. The outcome was based on histology if patients underwent surgery, or on results of clinical and ultrasound follow-up at 12 (±2) months. Multiple imputation was used when outcome based on follow-up was uncertain. RESULTS: The primary analysis included 17 centres that met strict quality criteria for surgical and follow-up data (5717 of all 8519 patients). 812 patients (14%) had a mass that was already in follow-up at study recruitment, therefore 4905 patients were included in the statistical analysis. The outcome was benign in 3441 (70%) patients and malignant in 978 (20%). Uncertain outcomes (486, 10%) were most often explained by limited follow-up information. The overall area under the receiver operating characteristic curve was highest for ADNEX with CA125 (0.94, 95% confidence interval 0.92 to 0.96), ADNEX without CA125 (0.94, 0.91 to 0.95) and SRRisk (0.94, 0.91 to 0.95), and lowest for RMI (0.89, 0.85 to 0.92). Calibration varied among centres for all models, however the ADNEX models and SRRisk were th more...
- Published
- 2020
11. Fatal Rift Valley Fever Outbreak Caused By Exposure To Meat From Sick And Dead Livestock: Uganda, July 2018
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Steven Balinandi, Alex Riolexus Ario, Deo N. Birungi, Bernadette Basuta Mirembe, David Muwanguzi, Esther Kisaakye, Steven Ndugwa Kabwama, Angella Musewa, Daniel Kadobera, Doreen Birungi, Benon Kwesiga, and Lilian Bulage more...
- Subjects
Veterinary medicine ,Geography ,business.industry ,medicine ,Outbreak ,Livestock ,Rift Valley fever ,medicine.disease ,business - Abstract
Background: Rift Valley Fever (RVF) is a viral hemorrhagic fever that can be fatal to humans and livestock. During June-October 2018, reported RVF cases increased sharply in eight western and central Ugandan districts. We investigated to identify the scope of the outbreak, determine risk factors, and recommend control measures.Methods: We defined a probable case as acute onset of unexplained fever with thrombocytopenia or leukopenia, plus ≥1 of: unexplained bleeding, blurred vision, or unexplained death during June–October 2018 in a resident of the affected districts. A confirmed case was a probable case with a positive PCR test for RVF. We reviewed medical records and actively searched for cases in communities. In a case-control study, we compared exposures of cases and age-, sex-, and neighbourhood-matched controls. We reviewed livestock RVF surveillance data.Results: We identified 19 cases (17 confirmed, 2 probable); 13 (68%) died. The mean age of the case-patients was 36 (range: 27-55) years. The attack rate in men (15/10,000) was 19 times higher than in women (0.78/10,000). Stratified epidemic curves indicated multiple point-source outbreaks, often following skinning/butchering livestock or eating grilled meat from livestock that had been sick or died of unknown causes (‘sick/dead livestock’). All case-patients with data (n=18) ate or butchered meat from sick/dead livestock. Of the 18 case-patients and 90 controls who participated in the case-control study, 10 case-patients (56%) and five controls (5.6%) cut or handled raw meat from sick/dead livestock (ORadj=14, 95%CI=2.8-72). RVF-seropositive livestock were identified from serum samples taken from farms where human cases had occurred.Conclusion. Human RVF outbreaks in Western and Central Uganda in 2018 were caused by contact with raw meat of sick/dead livestock. We recommended wearing protective gear during butchering, and safe handling and disposal of carcasses of sick/dead livestock. RVF surveillance data between human and livestock health sectors should be shared to facilitate early warning and detection for RVF. more...
- Published
- 2021
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12. Spatial linear dark field control on Subaru/SCExAO
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K. L. Miller, S. P. Bos, J. Lozi, O. Guyon, D. S. Doelman, S. Vievard, A. Sahoo, V. Deo, N. Jovanovic, F. Martinache, F. Snik, T. Currie
- Published
- 2021
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13. Fatal Rift Valley Fever Outbreak Caused By Exposure To Meat From Sick And Dead Livestock: Uganda, July 2018
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Musewa, Angella, primary, Mirembe, Bernadette B, additional, Ario, Alex R., additional, Birungi, Doreen, additional, Bulage, Lilian, additional, Kisaakye, Esther, additional, Kwesiga, Benon, additional, Kabwama, Steven N., additional, Muwanguzi, David, additional, Kadobera, Daniel, additional, Balinandi, Steven, additional, and Birungi, Deo N., additional more...
- Published
- 2021
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14. Synthesis, Anticancer, and Antibacterial Studies of Benzylidene Bearing 5-substituted and 3,5-disubstituted-2,4-Thiazolidinedione Derivatives
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Sethi, Navjot S., primary, Prasad, Deo N., additional, and Singh, Rajesh K., additional
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- 2021
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15. Modification in the Natural Bioactive Molecule: Piperine; A Continuing Source for the Drug Development
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Chopra, Bhawna, primary, Dhingra, Ashwani K., additional, and Prasad, Deo N., additional
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- 2020
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16. Virtual reality for acute pain in outpatient hysteroscopy: a randomised controlled trial
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Deo, N, primary, Khan, KS, additional, Mak, J, additional, Allotey, J, additional, Gonzalez Carreras, FJ, additional, Fusari, G, additional, and Benn, J, additional
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- 2020
- Full Text
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17. Synthesis and In Silico Molecular Docking Studies on Substituted Piperic Acid Derivatives as Inhibitors of Bacterial DNA Gyrase
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Chopra, Bhawna, primary, Dhingra, Ashwani K., additional, Prasad, Deo N., additional, Bhardwaj, Sakshi, additional, and Dubey, Sonal, additional
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- 2020
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18. Instant Gratification as a Method to Promote Critical Care Providers Practice Guideline Adherence: A Systematic Review
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Kashyap, R., primary, Deo, N., additional, Johnson, E., additional, Kancharla, K., additional, and O'Horo, J.C., additional
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- 2020
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19. Synthesis and Antimicrobial Activity of Naphthylamine Analogs Having Azetidinone and Thiazolidinone Moiety
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Ram Prakash Kapoor, Ashwani Kumar Dhingra, Bhawna Chopra, and Deo N. Parsad
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2-Azetidinone ,010405 organic chemistry ,Stereochemistry ,05 social sciences ,Antimicrobial ,Ring (chemistry) ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Naphthylamine ,chemistry ,0502 economics and business ,4-thiazolidinone ,Moiety ,050211 marketing ,Naphthalene - Abstract
To synthesize 2-naphthylamine analogs containing azetidin-2-one (4a–g) and thiazolidin-4-one (5a–g) ring moiety, with the aim of finding new potent antimicrobial agents.
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- 2017
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20. Validation of models to diagnose ovarian cancer in patients managed surgically or conservatively: multicentre cohort study
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Van Calster, B. Valentin, L. Froyman, W. Landolfo, C. Ceusters, J. Testa, A.C. Wynants, L. Sladkevicius, P. Van Holsbeke, C. Domali, E. Fruscio, R. Epstein, E. Franchi, D. Kudla, M.J. Chiappa, V. Alcazar, J.L. Leone, F.P.G. Buonomo, F. Coccia, M.E. Guerriero, S. Deo, N. Jokubkiene, L. Savelli, L. Fischerová, D. Czekierdowski, A. Kaijser, J. Coosemans, A. Scambia, G. Vergote, I. Bourne, T. Timmerman, D. more...
- Abstract
OBJECTIVE: To evaluate the performance of diagnostic prediction models for ovarian malignancy in all patients with an ovarian mass managed surgically or conservatively. DESIGN: Multicentre cohort study. SETTING: 36 oncology referral centres (tertiary centres with a specific gynaecological oncology unit) or other types of centre. PARTICIPANTS: Consecutive adult patients presenting with an adnexal mass between January 2012 and March 2015 and managed by surgery or follow-up. MAIN OUTCOME MEASURES: Overall and centre specific discrimination, calibration, and clinical utility of six prediction models for ovarian malignancy (risk of malignancy index (RMI), logistic regression model 2 (LR2), simple rules, simple rules risk model (SRRisk), assessment of different neoplasias in the adnexa (ADNEX) with or without CA125). ADNEX allows the risk of malignancy to be subdivided into risks of a borderline, stage I primary, stage II-IV primary, or secondary metastatic malignancy. The outcome was based on histology if patients underwent surgery, or on results of clinical and ultrasound follow-up at 12 (±2) months. Multiple imputation was used when outcome based on follow-up was uncertain. RESULTS: The primary analysis included 17 centres that met strict quality criteria for surgical and follow-up data (5717 of all 8519 patients). 812 patients (14%) had a mass that was already in follow-up at study recruitment, therefore 4905 patients were included in the statistical analysis. The outcome was benign in 3441 (70%) patients and malignant in 978 (20%). Uncertain outcomes (486, 10%) were most often explained by limited follow-up information. The overall area under the receiver operating characteristic curve was highest for ADNEX with CA125 (0.94, 95% confidence interval 0.92 to 0.96), ADNEX without CA125 (0.94, 0.91 to 0.95) and SRRisk (0.94, 0.91 to 0.95), and lowest for RMI (0.89, 0.85 to 0.92). Calibration varied among centres for all models, however the ADNEX models and SRRisk were the best calibrated. Calibration of the estimated risks for the tumour subtypes was good for ADNEX irrespective of whether or not CA125 was included as a predictor. Overall clinical utility (net benefit) was highest for the ADNEX models and SRRisk, and lowest for RMI. For patients who received at least one follow-up scan (n=1958), overall area under the receiver operating characteristic curve ranged from 0.76 (95% confidence interval 0.66 to 0.84) for RMI to 0.89 (0.81 to 0.94) for ADNEX with CA125. CONCLUSIONS: Our study found the ADNEX models and SRRisk are the best models to distinguish between benign and malignant masses in all patients presenting with an adnexal mass, including those managed conservatively. TRIAL REGISTRATION: ClinicalTrials.gov NCT01698632. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ. more...
- Published
- 2020
21. Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) alleles[S]
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Morgan, BM, Brown, AN, Deo, N, Harrop, TWR, Taiaroa, G, Mace, PD, Wilbanks, SM, Merriman, TR, Williams, MJA, McCormick, SPA, Morgan, BM, Brown, AN, Deo, N, Harrop, TWR, Taiaroa, G, Mace, PD, Wilbanks, SM, Merriman, TR, Williams, MJA, and McCormick, SPA more...
- Abstract
Plasma lipoprotein (a) [Lp(a)] levels are largely determined by variation in the LPA gene, which codes for apo(a). Genome-wide association studies (GWASs) have identified nonsynonymous variants in LPA that associate with low Lp(a) levels, although their effect on apo(a) function is unknown. We investigated two such variants, R990Q and R1771C, which were present in four null Lp(a) individuals, for structural and functional effects. Sequence alignments showed the R990 and R1771 residues to be highly conserved and homologous to each other and to residues associated with plasminogen deficiency. Structural modeling showed both residues to make several polar contacts with neighboring residues that would be ablated on substitution. Recombinant expression of the WT and R1771C apo(a) in liver and kidney cells showed an abundance of an immature form for both apo(a) proteins. A mature form of apo(a) was only seen with the WT protein. Imaging of the recombinant apo(a) proteins in conjunction with markers of the secretory pathway indicated a poor transit of R1771C into the Golgi. Furthermore, the R1771C mutant displayed a glycosylation pattern consistent with ER, but not Golgi, glycosylation. We conclude that R1771 and the equivalent R990 residue facilitate correct folding of the apo(a) kringle structure and mutations at these positions prevent the proper folding required for full maturation and secretion. To our knowledge, this is the first example of nonsynonymous variants in LPA being causative of a null Lp(a) phenotype. more...
- Published
- 2020
22. Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study
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Froyman, W. Landolfo, C. De Cock, B. Wynants, L. Sladkevicius, P. Testa, A.C. Van Holsbeke, C. Domali, E. Fruscio, R. Epstein, E. dos Santos Bernardo, M.J. Franchi, D. Kudla, M.J. Chiappa, V. Alcazar, J.L. Leone, F.P.G. Buonomo, F. Hochberg, L. Coccia, M.E. Guerriero, S. Deo, N. Jokubkiene, L. Kaijser, J. Coosemans, A. Vergote, I. Verbakel, J.Y. Bourne, T. Van Calster, B. Valentin, L. Timmerman, D. more...
- Abstract
Background: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complications and malignancy during the first 2 years of follow-up after adnexal masses have been classified as benign by use of ultrasonography. Methods: In the international, prospective, cohort International Ovarian Tumor Analysis Phase 5 (IOTA5) study, patients aged 18 years or older with at least one adnexal mass who had been selected for surgery or conservative management after ultrasound assessment were recruited consecutively from 36 cancer and non-cancer centres in 14 countries. Follow-up of patients managed conservatively is ongoing at present. In this 2-year interim analysis, we analysed patients who were selected for conservative management of an adnexal mass judged to be benign on ultrasound on the basis of subjective assessment of ultrasound images. Conservative management included ultrasound and clinical follow-up at intervals of 3 months and 6 months, and then every 12 months thereafter. The main outcomes of this 2-year interim analysis were cumulative incidence of spontaneous resolution of the mass, torsion or cyst rupture, or borderline or invasive malignancy confirmed surgically in patients with a newly diagnosed adnexal mass. IOTA5 is registered with ClinicalTrials.gov, number NCT01698632, and the central Ethics Committee and the Belgian Federal Agency for Medicines and Health Products, number S51375/B32220095331, and is ongoing. Findings: Between Jan 1, 2012, and March 1, 2015, 8519 patients were recruited to IOTA5. 3144 (37%) patients selected for conservative management were eligible for inclusion in our analysis, of whom 221 (7%) had no follow-up data and 336 (11%) were operated on before a planned follow-up scan was done. Of 2587 (82%) patients with follow-up data, 668 (26%) had a mass that was already in follow-up at recruitment, and 1919 (74%) presented with a new mass at recruitment (ie, not already in follow-up in the centre before recruitment). Median follow-up of patients with new masses was 27 months (IQR 14–38). The cumulative incidence of spontaneous resolution within 2 years of follow-up among those with a new mass at recruitment (n=1919) was 20·2% (95% CI 18·4–22·1), and of finding invasive malignancy at surgery was 0·4% (95% CI 0·1–0·6), 0·3% ( more...
- Published
- 2019
23. Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model
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Avila, MA, Walker, S, Wankell, M, Ho, V, White, R, Deo, N, Devine, C, Dewdney, B, Bhathal, P, Govaere, O, Roskams, T, Qiao, L, George, J, Hebbard, L, Avila, MA, Walker, S, Wankell, M, Ho, V, White, R, Deo, N, Devine, C, Dewdney, B, Bhathal, P, Govaere, O, Roskams, T, Qiao, L, George, J, and Hebbard, L more...
- Abstract
Liver cancer is a poor prognosis cancer with limited treatment options. To develop a new therapeutic approach, we derived HCC cells from a known model of murine hepatocellular carcinoma (HCC). We treated adiponectin (APN) knock-out mice with the carcinogen diethylnitrosamine, and the resulting tumors were 7-fold larger than wild-type controls. Tumors were disassociated from both genotypes and their growth characteristics evaluated. A52 cells from APN KO mice had the most robust growth in vitro and in vivo, and presented with pathology similar to the parental tumor. All primary tumors and cell lines exhibited activity of the mammalian target of Rapamycin (mTOR) and Src pathways. Subsequent combinatorial treatment, with the mTOR inhibitor Rapamycin and the Src inhibitor Dasatinib reduced A52 HCC growth 29-fold in vivo. Through protein and histological analyzes we observed activation of these pathways in human HCC, suggesting that targeting both mTOR and Src may be a novel approach for the treatment of HCC. more...
- Published
- 2019
24. Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study
- Author
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Froyman, W, Landolfo, C, De Cock, B, Wynants, L, Sladkevicius, P, Testa, A, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, dos Santos Bernardo, M, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Hochberg, L, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Kaijser, J, Coosemans, A, Vergote, I, Verbakel, J, Bourne, T, Van Calster, B, Valentin, L, Timmerman, D, Froyman, Wouter, Landolfo, Chiara, De Cock, Bavo, Wynants, Laure, Sladkevicius, Povilas, Testa, Antonia Carla, Van Holsbeke, Caroline, Domali, Ekaterini, Fruscio, Robert, Epstein, Elisabeth, dos Santos Bernardo, Maria José, Franchi, Dorella, Kudla, Marek Jerzy, Chiappa, Valentina, Alcazar, Juan Luis, Leone, Francesco Paolo Giuseppe, Buonomo, Francesca, Hochberg, Lauri, Coccia, Maria Elisabetta, Guerriero, Stefano, Deo, Nandita, Jokubkiene, Ligita, Kaijser, Jeroen, Coosemans, An, Vergote, Ignace, Verbakel, Jan Yvan, Bourne, Tom, Van Calster, Ben, Valentin, Lil, Timmerman, Dirk, Froyman, W, Landolfo, C, De Cock, B, Wynants, L, Sladkevicius, P, Testa, A, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, dos Santos Bernardo, M, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Hochberg, L, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Kaijser, J, Coosemans, A, Vergote, I, Verbakel, J, Bourne, T, Van Calster, B, Valentin, L, Timmerman, D, Froyman, Wouter, Landolfo, Chiara, De Cock, Bavo, Wynants, Laure, Sladkevicius, Povilas, Testa, Antonia Carla, Van Holsbeke, Caroline, Domali, Ekaterini, Fruscio, Robert, Epstein, Elisabeth, dos Santos Bernardo, Maria José, Franchi, Dorella, Kudla, Marek Jerzy, Chiappa, Valentina, Alcazar, Juan Luis, Leone, Francesco Paolo Giuseppe, Buonomo, Francesca, Hochberg, Lauri, Coccia, Maria Elisabetta, Guerriero, Stefano, Deo, Nandita, Jokubkiene, Ligita, Kaijser, Jeroen, Coosemans, An, Vergote, Ignace, Verbakel, Jan Yvan, Bourne, Tom, Van Calster, Ben, Valentin, Lil, and Timmerman, Dirk more...
- Abstract
Background: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complications and malignancy during the first 2 years of follow-up after adnexal masses have been classified as benign by use of ultrasonography. Methods: In the international, prospective, cohort International Ovarian Tumor Analysis Phase 5 (IOTA5) study, patients aged 18 years or older with at least one adnexal mass who had been selected for surgery or conservative management after ultrasound assessment were recruited consecutively from 36 cancer and non-cancer centres in 14 countries. Follow-up of patients managed conservatively is ongoing at present. In this 2-year interim analysis, we analysed patients who were selected for conservative management of an adnexal mass judged to be benign on ultrasound on the basis of subjective assessment of ultrasound images. Conservative management included ultrasound and clinical follow-up at intervals of 3 months and 6 months, and then every 12 months thereafter. The main outcomes of this 2-year interim analysis were cumulative incidence of spontaneous resolution of the mass, torsion or cyst rupture, or borderline or invasive malignancy confirmed surgically in patients with a newly diagnosed adnexal mass. IOTA5 is registered with ClinicalTrials.gov, number NCT01698632, and the central Ethics Committee and the Belgian Federal Agency for Medicines and Health Products, number S51375/B32220095331, and is ongoing. Findings: Between Jan 1, 2012, and March 1, 2015, 8519 patients were recruited to IOTA5. 3144 (37%) patients selected for conservative management were eligible for inclusion in our analysis, of whom 221 (7%) had no follow-up data and 336 (11%) were operated on before a planned follow-up scan was done. Of 2587 (82%) patients with follow-up data, 668 (26%) had a mass that was already in fo more...
- Published
- 2019
25. Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer
- Author
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Kumar, Sahil, primary, Sharma, Bandna, additional, Thakur, Kiran, additional, Bhardwaj, Tilak R., additional, Prasad, Deo N., additional, and Singh, Rajesh K., additional
- Published
- 2019
- Full Text
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26. Virtual reality for acute pain in outpatient hysteroscopy: a randomised controlled trial.
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Deo, N, Khan, KS, Mak, J, Allotey, J, Gonzalez Carreras, FJ, Fusari, G, and Benn, J
- Subjects
- *
RANDOMIZED controlled trials , *VIRTUAL reality , *HYSTEROSCOPY , *VIRTUAL reality therapy , *PAIN measurement , *ANXIETY , *PAIN - Abstract
Objective: To evaluate the effectiveness of virtual reality as a distraction technique in the management of acute pain and anxiety during outpatient hysteroscopy. Design: Parallel group, prospective randomised controlled trial. Setting: UK University Hospital. Methods: Forty consenting, eligible women were randomised to virtual reality intervention (immersive video content as a distraction method) or standard care during outpatient hysteroscopy from August to October 2018. Main outcome measures: Pain and anxiety outcomes were measured as a numeric rating score (scale 0–10). Results: Compared with standard care, women with virtual reality intervention experienced less average pain (score 6.0 versus 3.7, mean difference 2.3, 95% CI 0.61–3.99, P = 0.009) and anxiety (score 5.45 versus 3.3, mean difference 2.15, 95% CI 0.38–3.92, P = 0.02). Conclusion: Virtual reality was effective in reducing pain and anxiety during outpatient hysteroscopy in a mixed‐methods randomised control trial. Its wide potential role in ambulatory gynaecological procedures needs further evaluation. Virtual reality can be used as a part of a multimodal strategy to reduce acute pain and anxiety in patients undergoing outpatient hysteroscopy. Virtual reality can be used as a part of a multimodal strategy to reduce acute pain and anxiety in patients undergoing outpatient hysteroscopy. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
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27. Practical consensus recommendations regarding the management of sentinel lymph node issues in early breast cancer
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Kabra, Vedant, additional, Aggarwal, R., additional, Vardhan, S., additional, Singh, M., additional, Khandelwal, R., additional, Jain, S., additional, Sahani, S., additional, Saini, S., additional, Deo, N., additional, Kaul, R., additional, Parikh, P. M., additional, and Aggarwal, S., additional more...
- Published
- 2018
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28. A unique mullerian anomaly of bicollis uterus and vaginal septum with abnormal cervical smears—a case report of pregnancy in such an anomaly
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Deo, N. and Annan, H.
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- 2024
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29. Therapeutic Potential of N-heterocyclic Analogs as Anti-inflammatory Agents
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Dhingra, Ashwani K., primary, Chopra, Bhawna, additional, Dua, Jagdeep S., additional, and Prasad, Deo N., additional
- Published
- 2018
- Full Text
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30. Synthesis and Antimicrobial Activity of Naphthylamine Analogs Having Azetidinone and Thiazolidinone Moiety
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Chopra, Bhawna, primary, Dhingra, Ashwani K., additional, Kapoor, Ram P., additional, and Parsad, Deo N., additional
- Published
- 2017
- Full Text
- View/download PDF
31. Synthesis and In SilicoMolecular Docking Studies on Substituted Piperic Acid Derivatives as Inhibitors of Bacterial DNA Gyrase
- Author
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Chopra, Bhawna, Dhingra, Ashwani K., Prasad, Deo N., Bhardwaj, Sakshi, and Dubey, Sonal
- Abstract
Background: Piperine or piperic acid was isolated from fruits of Piper nigrum and had been reported as pharmacological valuable bioactive constituents. Keeping in view, a series of piperic acid-based N heterocyclic’s derivatives were synthesized and evaluated for antibacterial activity. All these prepared ligands were docked to study the molecular interactions and binding affinities against the protein PDB ID: 5 CDP. Objective: To meet the real need of newer antibacterials, we designed and synthesized scaffolds with good antibacterial activity. The obtained antibacterials have been validated in terms of ligand-protein interaction and thus prove to build up as good drug candidates. Methods: Antibacterial activity of the compounds were carried out against bacterial strains; three Grampositive and three Gram-negative bacterial strains using agar well diffusion method. In silico molecular docking studies were carried out using Glide (grid-based ligand docking) program incorporated in the Schrödinger molecular modeling package by Maestro 11.0. Results: Compounds BC 28, BC 32, and BC 33 exhibits antibacterial activity along with Glide docking score of -8.580, -9.753 kcal/mol, and -8.813 kcal/mol, respectively. Docking studies explained hydrogen bonding, pi-pi, and hydrophobic interactions with amino acid residues which explain the binding affinity of the most docked ligand with protein. Conclusion: In the present study, substituted piperic acid was synthesized and evaluated as antibacterial compared with standard drug ciprofloxacin and results interpret that having nitrogen as heteroatom in the heterocyclic nucleus found to be more potent than the standard drug ciprofloxacin. On comparing, substitution with electron-donating groups generates excellent antibacterial potential against the bacterial strains. It was also proved that having substitution with electron-donating groups on meta and para position with triazoline ring system exhibits greater potential while compounds which have a meta- electron-donating substituent showed lesser activity with thiazole nucleus. In addition, structure-based activities of the prepared analogs were discussed under Structure-Activity Relationship (SAR) section. more...
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- 2020
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32. Multicomponent Catalytic Synthesis of 1,5-Benzodiazepines: An Update
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Singh, Rajesh K., Sharda, Sadhna, Sharma, Shikha, Kumar, Sahil, and Prasad, Deo N.
- Abstract
1,5-Benzodiazepines are considered some of the most vital classes of heterocyclic compounds due to their amazing biological and varied pharmacological activities. They are regarded as privileged structures and therefore have been striking synthetic targets for organic and medicinal chemists over the last decade. This results in the exploration of various silica supported catalysts, Lewis acids, organoacids, magnetic nanoparticles and other miscellaneous catalysts that have been investigated till date for an efficient and green synthesis of 1,5-benzodiazepine and its derivatives. The current review article primarily covers the one-pot green chemical synthesis of 1,5- benzodiazepines using various novel catalysts. The main motive of this review is the assessment of the literature on various catalysts along with their yield, reaction condition, and mechanism of action. In the end, the entire catalysts are structured systematically into various Lewis acids, Bronsted organoacids, supported catalysts, nanocatalysts, and miscellaneous catalysts and are presented in the form of tables for quick ‘at a glance’ study of catalysts, their reaction condition, time taken, etc. more...
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- 2020
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33. Current Progress in the Multicomponent Catalytic Synthesis of Amidoalkyl-Naphthols: An Update
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Singh, Rajesh K., Dhiman, Ashima, Chaudhary, Shallu, Prasad, Deo N., and Kumar, Sahil
- Abstract
Amidoalkyl-2-naphthol is one of the vital synthetic intermediates which occupy an imperative position in medicinal chemistry due to its amazing biological, pharmacological as well as industrial and synthetic applications. Owing to its diverse pharmaceutical activities, hundreds of scientific literature are available, signifying the efficient synthesis of this intermediate using various catalysts. Most of these literature methods suffer from low yield and harsh reaction conditions that further ignited the researcher to explore for another green catalyst and fresh methodologies. This review summarizes the last five years progress in the catalytic synthesis of 1-amidoalkyl-2-naphthols using various heterogenous, homogenous and nanocatalysts along with their mechanism of action. Various advantages like green synthesis, atom economy, clean reaction profile and catalyst recovery are discussed which facilitate the scientist to probe and stimulate the study on this scaffold. In the end, the catalysts and reactions condition are organized into the tables for swift at a glance understanding of different catalysts used with their yield and time taken for the synthesis. more...
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- 2020
- Full Text
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34. Prodrugs of Non-steroidal Anti-inflammatory Drugs (NSAIDs): A Long March Towards Synthesis of Safer NSAIDs
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Sehajpal, Shikha, Prasad, Deo N., and Singh, Rajesh K.
- Abstract
As a therapeutic group, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used, prescribed and over the counter (OTC) medications for the treatment of inflammatory diseases, but suffering from several undesired side effects, the most important being ulcerogenicity, mucosal hemorrhage and gastritis. Most of the NSAID moieties are chemically composed of carboxylic functional groups and this could be one of the reasons for the damage to the mucosal lining. The prodrug designing is one of the several strategies used to overcome this drawback. Hence, in the last decade, the design and the synthesis of prodrugs of NSAIDs have been explored and given much attention by medicinal chemists. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. This review is aimed to highlight and provide important information on NSAID prodrugs that have been designed and reported to be safe and more effective. This review will also focus on NSAID prodrugs that have been designed for improving therapeutic i.e. anti-inflammatory action as well as improving drug delivery at the target site. The most common derivatives of carboxylic NSAIDs that are discussed here belong to the chemical classes of esters, amides, anhydrides, acetals and the other derivatives with completely masked carboxylic groups. The successful prodrugs were listed and their molecular structures were also demonstrated here. The present review covers the recent updates present in literature and will surely provide a greater insight into the designing of safer NSAIDs in the future. more...
- Published
- 2018
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35. Therapeutic Potential of N-heterocyclic Analogs as Anti-inflammatory Agents
- Author
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Dhingra, Ashwani K., Chopra, Bhawna, Dua, Jagdeep S., and Prasad, Deo N.
- Abstract
Background: Various mediators and anti-inflammatory drugs were used since from a long time but it is still a challenge for the medicinal chemists to treat or reduce the symptoms of inflammatory diseases. Most of the clinically used anti-inflammatory drugs such as NSAIDs, Coxibs and GCs are allied with considerable toxicity. Objective: The search of novel anti-inflammatory agent is not an ending process. Although the drug treatment has been improved steadily but yet, it is still there is a need to develop more potent therapeutic agents. Method: Reported literature survey has been studied to summarize the nitrogen containing moieties which were utilized as potential therapeutic agents. Results: A variety of N-heterocyclic analogs are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal and anti-HIV. However, numerous approaches were used to overcome the toxicity level such as co-administration with suitable agent/substance which provides protection against toxicity as well to synthesise new potent and safe anti-inflammatory drug. Conclusion: The present review summarizes the synthetic methodology and therapeutic potential of some N-heterocyclic analogs as potent anti-inflammatory agents. more...
- Published
- 2017
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36. Methods for Reconstructing Interbank Networks from Limited Information: A Comparison
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Piero Mazzarisi, Fabrizio Lillo, Abergel F, Aoyama H, Chakrabarti BK, Chakraborti A, Deo N, Raina D, Vodenska I, Mazzarisi, Piero, Lillo, Fabrizio, Abergel, F, Aoyama, H, Chakrabarti, BK, Chakraborti, A, Deo, N, Raina, D, and Vodenska, I more...
- Subjects
Communication ,Kullback–Leibler divergence ,maximum entropy ,business.industry ,Computer science ,Principle of maximum entropy ,Fitness model ,Complex network ,computer.software_genre ,01 natural sciences ,010305 fluids & plasmas ,Interbank network ,Interbank market ,complex network ,Goodness of fit ,0103 physical sciences ,Interbank lending market ,Minification ,Data mining ,010306 general physics ,business ,computer - Abstract
In this chapter, we review and compare some methods for the reconstruction of an interbank network from limited information. By exploiting the theory of complex networks and some ideas from statistical physics, we mainly focus on three different methods based on the maximum entropy principle, the relative entropy minimization, and the fitness model. We apply our analysis to the credit network of electronic Market for Interbank Deposit (e-MID) in 2011. In comparing the goodness of fit of the proposed methods, we look at the topological network properties and how reliably each method reproduces the real-world network. more...
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- 2017
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37. External validation of the ovarian-adnexal reporting and data system (O-RADS) lexicon and the international ovarian tumor analysis 2-step strategy to stratify ovarian tumors into O-RADS risk groups
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Stefan Timmerman, Lil Valentin, Jolien Ceusters, Antonia C. Testa, Chiara Landolfo, Povilas Sladkevicius, Caroline Van Holsbeke, Ekaterini Domali, Robert Fruscio, Elisabeth Epstein, Dorella Franchi, Marek J. Kudla, Valentina Chiappa, Juan L. Alcazar, Francesco P. G. Leone, Francesca Buonomo, Maria Elisabetta Coccia, Stefano Guerriero, Nandita Deo, Ligita Jokubkiene, Jeroen Kaijser, Giovanni Scambia, Rochelle Andreotti, Dirk Timmerman, Tom Bourne, Ben Van Calster, Wouter Froyman, Timmerman, S, Valentin, L, Ceusters, J, Testa, A, Landolfo, C, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Kaijser, J, Scambia, G, Andreotti, R, Timmerman, D, Bourne, T, Van Calster, B, and Froyman, W more...
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Cancer Research ,Settore MED/40 - GINECOLOGIA E OSTETRICIA ,Sensitivity ,Oncology ,Ovarian cancer ,ultrasound ,Surgery ,Ovarian-Adnexal Reporting and Data System (O-RADS) ,Multicenter ,Prediction ,Ovarian Tumors ,Cancer ,Model - Abstract
ImportanceCorrect diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy.ObjectiveTo investigate the diagnostic performance of the O-RADS lexicon and the IOTA 2-step strategy.Design, Setting, and ParticipantsRetrospective external diagnostic validation study based on interim data of IOTA5, a prospective international multicenter cohort study, in 36 oncology referral centers or other types of centers. A total of 8519 consecutive adult patients presenting with an adnexal mass between January 1, 2012, and March 1, 2015, and treated either with surgery or conservatively were included in this diagnostic study. Twenty-five patients were excluded for withdrawal of consent, 2777 were excluded from 19 centers that did not meet predefined data quality criteria, and 812 were excluded because they were already in follow-up at recruitment. The analysis included 4905 patients with a newly detected adnexal mass in 17 centers that met predefined data quality criteria. Data were analyzed from January 31 to March 1, 2022.ExposuresStratification into O-RADS categories (malignancy risk Main Outcomes and MeasuresObserved prevalence of malignancy in each O-RADS risk category, as well as sensitivity and specificity. The reference standard was the status of the tumor at inclusion, determined by histology or clinical and ultrasonographic follow-up for 1 year. Multiple imputation was used for uncertain outcomes owing to inconclusive follow-up information.ResultsMedian age of the 4905 patients was 48 years (IQR, 36-62 years). Data on race and ethnicity were not collected. A total of 3441 tumors (70%) were benign, 978 (20%) were malignant, and 486 (10%) had uncertain classification. Using the O-RADS lexicon resulted in 1.1% (24 of 2196) observed prevalence of malignancy in O-RADS 2, 4% (34 of 857) in O-RADS 3, 27% (246 of 904) in O-RADS 4, and 78% (732 of 939) in O-RADS 5; the corresponding results for the IOTA 2-step strategy were 0.9% (18 of 1984), 4% (58 of 1304), 30% (206 of 690), and 82% (756 of 927). At the 10% risk threshold (O-RADS 4-5), the O-RADS lexicon had 92% sensitivity (95% CI, 87%-96%) and 80% specificity (95% CI, 74%-85%), and the IOTA 2-step strategy had 91% sensitivity (95% CI, 84%-95%) and 85% specificity (95% CI, 80%-88%).Conclusions and RelevanceThe findings of this external diagnostic validation study suggest that both the O-RADS lexicon and the IOTA 2-step strategy can be used to stratify patients into risk groups. However, the observed malignancy rate in O-RADS 2 was not clearly below 1%. more...
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- 2023
38. Benign descriptors and ADNEX in two-step strategy to estimate risk of malignancy in ovarian tumors: retrospective validation on IOTA 5 multicenter cohort
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C. Landolfo, T. Bourne, W. Froyman, B. Van Calster, J. Ceusters, A. C. Testa, L. Wynants, P. Sladkevicius, C. Van Holsbeke, E. Domali, R. Fruscio, E. Epstein, D. Franchi, M. J. Kudla, V. Chiappa, J. L. Alcazar, F. P. G. Leone, F. Buonomo, M. E. Coccia, S. Guerriero, N. Deo, L. Jokubkiene, L. Savelli, D. Fischerova, A. Czekierdowski, J. Kaijser, A. Coosemans, G. Scambia, I. Vergote, D. Timmerman, L. Valentin, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Landolfo, C, Bourne, T, Froyman, W, Van Calster, B, Ceusters, J, Testa, A, Wynants, L, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Savelli, L, Fischerova, D, Czekierdowski, A, Kaijser, J, Coosemans, A, Scambia, G, Vergote, I, Timmerman, D, and Valentin, L more...
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Radiological and Ultrasound Technology ,Benign simple descriptor ,Validation study ,IOTA ,Obstetrics and Gynecology ,ultrasonography ,General Medicine ,benign simple descriptors ,ovarian neoplasms ,benign simple descriptor ,ovarian neoplasm ,Ovarian neoplasm ,Settore MED/40 - GINECOLOGIA E OSTETRICIA ,Reproductive Medicine ,validation study ,ADNEX model ,Radiology, Nuclear Medicine and imaging ,Ultrasonography - Abstract
OBJECTIVE: Previous work has suggested that the ultrasound-based benign simple descriptors (BDs) can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. This study aimed to validate a modified version of the BDs and to validate a two-step strategy to estimate the risk of malignancy, in which the modified BDs are followed by the Assessment of Different NEoplasias in the adneXa (ADNEX) model if modified BDs do not apply. METHODS: This was a retrospective analysis using data from the 2-year interim analysis of the International Ovarian Tumor Analysis (IOTA) Phase-5 study, in which consecutive patients with at least one adnexal mass were recruited irrespective of subsequent management (conservative or surgery). The main outcome was classification of tumors as benign or malignant, based on histology or on clinical and ultrasound information during 1 year of follow-up. Multiple imputation was used when outcome based on follow-up was uncertain according to predefined criteria. RESULTS: A total of 8519 patients were recruited at 36 centers between 2012 and 2015. We excluded patients who were already in follow-up at recruitment and all patients from 19 centers that did not fulfil our criteria for good-quality surgical and follow-up data, leaving 4905 patients across 17 centers for statistical analysis. Overall, 3441 (70%) tumors were benign, 978 (20%) malignant and 486 (10%) uncertain. The modified BDs were applicable in 1798/4905 (37%) tumors, of which 1786 (99.3%) were benign. The two-step strategy based on ADNEX without CA125 had an area under the receiver-operating-characteristics curve (AUC) of 0.94 (95% CI, 0.92-0.96). The risk of malignancy was slightly underestimated, but calibration varied between centers. A sensitivity analysis in which we expanded the definition of uncertain outcome resulted in 1419 (29%) tumors with uncertain outcome and an AUC of the two-step strategy without CA125 of 0.93 (95% CI, 0.91-0.95). CONCLUSION: A large proportion of adnexal masses can be classified as benign by the modified BDs. For the remaining masses, the ADNEX model can be used to estimate the risk of malignancy. This two-step strategy is convenient for clinical use. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. ispartof: ULTRASOUND IN OBSTETRICS & GYNECOLOGY vol:61 issue:2 pages:231-242 ispartof: location:England status: published more...
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- 2022
39. Validation of models to diagnose ovarian cancer in patients managed surgically or conservatively: multicentre cohort study
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Ekaterini Domali, An Coosemans, Giovanni Scambia, Laure Wynants, J. Kaijser, Valentina Chiappa, Dirk Timmerman, Jolien Ceusters, Juan Luis Alcázar, Luca Savelli, Daniela Fischerova, Caroline Van Holsbeke, Elisabeth Epstein, Dorella Franchi, Povilas Sladkevicius, Nandita Deo, Ignace Vergote, Artur Czekierdowski, Tom Bourne, Maria Elisabetta Coccia, Ben Van Calster, Antonia Carla Testa, Marek Kudla, Lil Valentin, Chiara Landolfo, Ligita Jokubkiene, F. Leone, Wouter Froyman, Robert Fruscio, Stefano Guerriero, F. Buonomo, Van Calster, B, Valentin, L, Froyman, W, Landolfo, C, Ceusters, J, Testa, A, Wynants, L, Sladkevicius, P, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Savelli, L, Fischerova, D, Czekierdowski, A, Kaijser, J, Coosemans, A, Scambia, G, Vergote, I, Bourne, T, Timmerman, D, Epidemiologie, and RS: CAPHRI - R5 - Optimising Patient Care more...
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EXTERNAL VALIDATION ,RISK MODELS ,SURGERY ,PREDICTION ,Conservative Treatment ,Adnexal mass ,0302 clinical medicine ,Prospective Studies ,Stage (cooking) ,Prospective cohort study ,Membrane Protein ,ULTRASOUND ,Ultrasonography ,Ovarian Neoplasms ,Aged, 80 and over ,CALIBRATION ,030219 obstetrics & reproductive medicine ,General Medicine ,Middle Aged ,TUMORS ,030220 oncology & carcinogenesis ,Female ,Radiology ,Life Sciences & Biomedicine ,Cohort study ,Human ,Adult ,IOTA ADNEX MODEL ,medicine.medical_specialty ,Adolescent ,Ovariectomy ,Malignancy ,Risk Assessment ,1117 Public Health and Health Services ,03 medical and health sciences ,Young Adult ,Medicine, General & Internal ,General & Internal Medicine ,medicine ,Fallopian Tube Neoplasms ,Humans ,Fallopian Tube Neoplasm ,MASSES ,Aged ,MALIGNANCY ,Science & Technology ,Receiver operating characteristic ,business.industry ,Research ,Ovarian Neoplasm ,Membrane Proteins ,1103 Clinical Sciences ,medicine.disease ,Confidence interval ,Clinical trial ,Prospective Studie ,Logistic Models ,CA-125 Antigen ,business - Abstract
ObjectiveTo evaluate the performance of diagnostic prediction models for ovarian malignancy in all patients with an ovarian mass managed surgically or conservatively.DesignMulticentre cohort study.Setting36 oncology referral centres (tertiary centres with a specific gynaecological oncology unit) or other types of centre.ParticipantsConsecutive adult patients presenting with an adnexal mass between January 2012 and March 2015 and managed by surgery or follow-up.Main outcome measuresOverall and centre specific discrimination, calibration, and clinical utility of six prediction models for ovarian malignancy (risk of malignancy index (RMI), logistic regression model 2 (LR2), simple rules, simple rules risk model (SRRisk), assessment of different neoplasias in the adnexa (ADNEX) with or without CA125). ADNEX allows the risk of malignancy to be subdivided into risks of a borderline, stage I primary, stage II-IV primary, or secondary metastatic malignancy. The outcome was based on histology if patients underwent surgery, or on results of clinical and ultrasound follow-up at 12 (±2) months. Multiple imputation was used when outcome based on follow-up was uncertain.ResultsThe primary analysis included 17 centres that met strict quality criteria for surgical and follow-up data (5717 of all 8519 patients). 812 patients (14%) had a mass that was already in follow-up at study recruitment, therefore 4905 patients were included in the statistical analysis. The outcome was benign in 3441 (70%) patients and malignant in 978 (20%). Uncertain outcomes (486, 10%) were most often explained by limited follow-up information. The overall area under the receiver operating characteristic curve was highest for ADNEX with CA125 (0.94, 95% confidence interval 0.92 to 0.96), ADNEX without CA125 (0.94, 0.91 to 0.95) and SRRisk (0.94, 0.91 to 0.95), and lowest for RMI (0.89, 0.85 to 0.92). Calibration varied among centres for all models, however the ADNEX models and SRRisk were the best calibrated. Calibration of the estimated risks for the tumour subtypes was good for ADNEX irrespective of whether or not CA125 was included as a predictor. Overall clinical utility (net benefit) was highest for the ADNEX models and SRRisk, and lowest for RMI. For patients who received at least one follow-up scan (n=1958), overall area under the receiver operating characteristic curve ranged from 0.76 (95% confidence interval 0.66 to 0.84) for RMI to 0.89 (0.81 to 0.94) for ADNEX with CA125.ConclusionsOur study found the ADNEX models and SRRisk are the best models to distinguish between benign and malignant masses in all patients presenting with an adnexal mass, including those managed conservatively.Trial registrationClinicalTrials.gov NCT01698632. more...
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- 2020
40. Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study
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Valentina Chiappa, Antonia Carla Testa, Chiara Landolfo, An Coosemans, Ignace Vergote, J. Kaijser, F. Leone, Lil Valentin, Bavo De Cock, Laure Wynants, Dirk Timmerman, Maria José dos Santos Bernardo, Juan Luis Alcázar, Ligita Jokubkiene, Wouter Froyman, Ben Van Calster, Povilas Sladkevicius, Robert Fruscio, L. Hochberg, Stefano Guerriero, Jan Y Verbakel, F. Buonomo, Maria Elisabetta Coccia, Nandita Deo, Marek Kudla, Ekaterini Domali, Tom Bourne, Caroline Van Holsbeke, Elisabeth Epstein, Dorella Franchi, Froyman, W, Landolfo, C, De Cock, B, Wynants, L, Sladkevicius, P, Testa, A, Van Holsbeke, C, Domali, E, Fruscio, R, Epstein, E, dos Santos Bernardo, M, Franchi, D, Kudla, M, Chiappa, V, Alcazar, J, Leone, F, Buonomo, F, Hochberg, L, Coccia, M, Guerriero, S, Deo, N, Jokubkiene, L, Kaijser, J, Coosemans, A, Vergote, I, Verbakel, J, Bourne, T, Van Calster, B, Valentin, L, Timmerman, D, The Linbury Trust, Epidemiologie, and RS: CAPHRI - R5 - Optimising Patient Care more...
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Adult ,medicine.medical_specialty ,PREMENOPAUSAL ,Adolescent ,BENIGN ,EXPECTANT MANAGEMENT ,Malignancy ,Adnexal mass ,Cohort Studies ,Diagnosis, Differential ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Neoplasms ,medicine ,Humans ,Cumulative incidence ,1112 Oncology and Carcinogenesis ,Prospective Studies ,Oncology & Carcinogenesis ,Prospective cohort study ,ULTRASOUND ,Aged ,Ultrasonography ,Ovarian Neoplasms ,030219 obstetrics & reproductive medicine ,Science & Technology ,business.industry ,General surgery ,Incidence (epidemiology) ,NATURAL-HISTORY ,Middle Aged ,medicine.disease ,Interim analysis ,CANCER ,POSTMENOPAUSAL WOMEN ,Oncology ,Adnexal Diseases ,030220 oncology & carcinogenesis ,Cohort ,DERMOID CYSTS ,Female ,SIMPLE ADNEXAL CYSTS ,business ,FOLLOW-UP ,Life Sciences & Biomedicine ,Cohort study - Abstract
BACKGROUND: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complications and malignancy during the first 2 years of follow-up after adnexal masses have been classified as benign by use of ultrasonography. METHODS: In the international, prospective, cohort International Ovarian Tumor Analysis Phase 5 (IOTA5) study, patients aged 18 years or older with at least one adnexal mass who had been selected for surgery or conservative management after ultrasound assessment were recruited consecutively from 36 cancer and non-cancer centres in 14 countries. Follow-up of patients managed conservatively is ongoing at present. In this 2-year interim analysis, we analysed patients who were selected for conservative management of an adnexal mass judged to be benign on ultrasound on the basis of subjective assessment of ultrasound images. Conservative management included ultrasound and clinical follow-up at intervals of 3 months and 6 months, and then every 12 months thereafter. The main outcomes of this 2-year interim analysis were cumulative incidence of spontaneous resolution of the mass, torsion or cyst rupture, or borderline or invasive malignancy confirmed surgically in patients with a newly diagnosed adnexal mass. IOTA5 is registered with ClinicalTrials.gov, number NCT01698632, and the central Ethics Committee and the Belgian Federal Agency for Medicines and Health Products, number S51375/B32220095331, and is ongoing. FINDINGS: Between Jan 1, 2012, and March 1, 2015, 8519 patients were recruited to IOTA5. 3144 (37%) patients selected for conservative management were eligible for inclusion in our analysis, of whom 221 (7%) had no follow-up data and 336 (11%) were operated on before a planned follow-up scan was done. Of 2587 (82%) patients with follow-up data, 668 (26%) had a mass that was already in follow-up at recruitment, and 1919 (74%) presented with a new mass at recruitment (ie, not already in follow-up in the centre before recruitment). Median follow-up of patients with new masses was 27 months (IQR 14-38). The cumulative incidence of spontaneous resolution within 2 years of follow-up among those with a new mass at recruitment (n=1919) was 20·2% (95% CI 18·4-22·1), and of finding invasive malignancy at surgery was 0·4% (95% CI 0·1-0·6), 0·3% ( more...
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- 2019
41. Option Pricing and Hedging with Liquidity Costs and Market Impact
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Frédéric Abergel, Grégoire Loeper, Mathématiques et Informatique pour la Complexité et les Systèmes (MICS), CentraleSupélec, Monash University [Clayton], Abergel, F, Aoyama, H, Chakrabarti, BK, Chakraborti, A, Deo, N, Raina, D, and Vodenska, I more...
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050208 finance ,Stochastic volatility ,Financial economics ,05 social sciences ,Liquidity crisis ,Liquidity risk ,01 natural sciences ,Market liquidity ,010104 statistics & probability ,Price equation ,Valuation of options ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,0502 economics and business ,Order book ,Econometrics ,Business ,0101 mathematics ,Market impact - Abstract
International audience; We study the influence of taking liquidity costs and market impact into account when hedging a contingent claim. In the continuous time setting and under the assumption of perfect replication, we derive a fully non-linear pricing partial differential equation, and characterize its parabolic nature according to the value of a numerical parameter interpreted as a relaxation coefficient for market impact. We also investigate the case of stochastic volatility models with pseudo-optimal strategies. more...
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- 2017
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42. Virtual reality for the management of pain and anxiety during outpatient manual vacuum aspiration for miscarriage or incomplete abortion: a mixed methods trial.
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McDougall AA, Bard E, Jesner O, Ibrahim S, Rouabhi S, and Deo N
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- Humans, Female, Adult, Pregnancy, Prospective Studies, Abortion, Incomplete therapy, Abortion, Spontaneous psychology, Pain Management methods, Pain Measurement, Young Adult, Pain, Procedural psychology, Pain, Procedural therapy, Pain, Procedural etiology, Anxiety etiology, Anxiety therapy, Vacuum Curettage methods, Virtual Reality
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Purpose: To evaluate the efficacy and acceptability of virtual reality (VR) as a distraction technique in the management of acute pain and anxiety during outpatient uterine aspiration using a manual vacuum aspirator (MVA)., Materials and Methods: This mixed methods study included a prospective multi-centre randomised controlled trial and structured individual interviews. Of the 72 patients approached, 50 consenting, eligible participants were randomised to VR intervention (immersive video content 'The Forest of Serenity') or standard care during MVA for the management of miscarriage or incomplete abortion from July 2021-July 2022 across two university hospitals in London, UK. Expected and actual pain scores, and anxiety before and after the procedure were measured as numeric rating scores (0-10). Structured interviews were undertaken after the procedure in women randomised to VR. Statistical analysis of pain and anxiety scores were by intention-to-treat including all randomised participants, using Stata-12 software. Qualitative analysis was achieved by thematic analysis of transcribed interviews., Results: There was no significant difference in pain or anxiety scores reported by participants randomised to VR compared with standard care. Mean worst pain scores were 5.98 and 6.88 in the standard care and VR groups respectively (p-value 0.13), with corresponding anxiety scores at the end of the procedure 3.94 and 3.3 (p-value 0.57). Qualitative analysis from interviews was highly favourable from women randomised to VR with all participants reporting a positive experience. 90% (18/20) of participants reported that VR reduced their anxiety and 71% (15/21) stated that it helped to reduce or distract from their pain., Conclusion: While virtual reality did not decrease pain or anxiety scores during MVA, it is a feasible and acceptable option that may improve patient experience. more...
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- 2024
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43. Racial Disparities in Cancer Stage at Diagnosis and Survival for Adolescents and Young Adults.
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Taparra K, Kekumano K, Benavente R, Roberto L, Gimmen M, Shontell R, Cakobau H, Deo N, Kinslow CJ, Betof Warner A, Deville C, Shing JZ, Vo JB, Patel MI, and Pollom E
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- Humans, Female, Male, Adolescent, Young Adult, Adult, Retrospective Studies, United States epidemiology, Health Status Disparities, Neoplasms mortality, Neoplasms ethnology, Neoplasms diagnosis, Neoplasm Staging
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Importance: There are limited studies assessing stage at diagnosis and risk of death among all 5 federally defined races in the US among adolescent and young adult (AYA) patients with cancer., Objective: To identify racial disparities in stage at diagnosis and survival among AYA patients with cancer., Design, Setting, and Participants: This retrospective cohort study used data from a US national hospital-based oncology database on AYA patients, aged 15 to 39 years, with the 10 deadliest cancers among AYA patients who received a diagnosis from January 1, 2004, to December 31, 2017, with 6 months or more of follow-up. Analyses by race were categorized by the 5 federally defined races in the US: American Indian or Alaska Native, Asian, Black, Native Hawaiian or Other Pacific Islander, and non-Hispanic White (hereafter, White). White patients served as the majority reference group. Statistical analysis was performed from November 2022 to September 2023., Main Outcomes and Measures: The primary end points were late stage at diagnosis (logistic regression with adjusted odds ratios [AORs] and 95% CIs) and overall survival (log-rank tests and Cox proportional hazards regression with adjusted hazard ratios [AHRs] and 95% CIs)., Results: A total of 291 899 AYA patients (median age, 33 years [IQR, 28-37 years]; 186 549 female patients [64%]; 189 812 [65%] with stage I or II cancers) were evaluated. The cohort included 1457 American Indian or Alaska Native patients (1%), 8412 Asian patients (3%), 40 851 Black patients (14%), 987 Native Hawaiian or Other Pacific Islander patients (0.3%), and 240 192 White patients (82%). Cancers included breast (n = 79 195 [27%]), lymphoma (n = 45 500 [16%]), melanoma (n = 36 724 [13%]), testis (n = 31 413 [11%]), central nervous system (n = 26 070 [9%]), colon or rectum (n = 22 545 [8%]), cervix (n = 20 923 [7%]), sarcoma (n = 14 951 [5%]), ovary (n = 8982 [3%]), and lung (n = 5596 [2%]). Risk of late-stage diagnosis was higher for Asian (AOR, 1.20; 95% CI, 1.14-1.26), Black (AOR, 1.40; 95% CI, 1.36-1.43), and Native Hawaiian or Other Pacific Islander (AOR, 1.34; 95% CI, 1.16-1.55) patients compared with White patients. Overall survival differed by race for all cancer sites, except cancers of the central nervous system and ovary. Risk of death was higher for American Indian or Alaska Native (AHR, 1.15; 95% CI, 1.02-1.30), Black (AHR, 1.22; 95% CI, 1.19-1.26), and Native Hawaiian or Other Pacific Islander (AHR, 1.25; 95% CI, 1.09-1.44) patients but lower for Asian patients (AHR, 0.90; 95% CI, 0.85-0.95) compared with White patients., Conclusions and Relevance: This cohort study of AYA patients suggests that stage at diagnosis and survival varied across races for the 10 deadliest AYA cancers. These results support the need for tailored interventions and informed public policy to achieve cancer care equity for all races. more...
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- 2024
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44. Association of hypothyroidism with outcomes in hospitalized adults with COVID-19: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry.
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Bogojevic M, Bansal V, Pattan V, Singh R, Tekin A, Sharma M, La Nou AT, LeMahieu AM, Hanson AC, Schulte PJ, Deo N, Qamar S, Zec S, Valencia Morales DJ, Perkins N, Kaufman M, Denson JL, Melamed R, Banner-Goodspeed VM, Christie AB, Tarabichi Y, Heavner S, Kumar VK, Walkey AJ, Gajic O, Bhagra S, Kashyap R, Lal A, and Domecq JP more...
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- Humans, Male, Female, Middle Aged, Aged, Severity of Illness Index, Adult, Comorbidity, Cohort Studies, SARS-CoV-2, Intensive Care Units statistics & numerical data, Aged, 80 and over, COVID-19 mortality, COVID-19 complications, COVID-19 epidemiology, Hypothyroidism epidemiology, Hypothyroidism complications, Registries, Hospitalization statistics & numerical data, Hospital Mortality
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Introduction: Coronavirus disease 2019 (COVID-19) is associated with high rates of morbidity and mortality. Primary hypothyroidism is a common comorbid condition, but little is known about its association with COVID-19 severity and outcomes. This study aims to identify the frequency of hypothyroidism in hospitalized patients with COVID-19 as well as describe the differences in outcomes between patients with and without pre-existing hypothyroidism using an observational, multinational registry., Methods: In an observational cohort study we enrolled patients 18 years or older, with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection between March 2020 and February 2021. The primary outcomes were (1) the disease severity defined as per the World Health Organization Scale for Clinical Improvement, which is an ordinal outcome corresponding with the highest severity level recorded during a patient's index COVID-19 hospitalization, (2) in-hospital mortality and (3) hospital-free days. Secondary outcomes were the rate of intensive care unit (ICU) admission and ICU mortality., Results: Among the 20,366 adult patients included in the study, pre-existing hypothyroidism was identified in 1616 (7.9%). The median age for the Hypothyroidism group was 70 (interquartile range: 59-80) years, and 65% were female and 67% were White. The most common comorbidities were hypertension (68%), diabetes (42%), dyslipidemia (37%) and obesity (28%). After adjusting for age, body mass index, sex, admission date in the quarter year since March 2020, race, smoking history and other comorbid conditions (coronary artery disease, hypertension, diabetes and dyslipidemia), pre-existing hypothyroidism was not associated with higher odds of severe disease using the World Health Organization disease severity index (odds ratio [OR]: 1.02; 95% confidence interval [CI]: 0.92, 1.13; p = .69), in-hospital mortality (OR: 1.03; 95% CI: 0.92, 1.15; p = .58) or differences in hospital-free days (estimated difference 0.01 days; 95% CI: -0.45, 0.47; p = .97). Pre-existing hypothyroidism was not associated with ICU admission or ICU mortality in unadjusted as well as in adjusted analysis., Conclusions: In an international registry, hypothyroidism was identified in around 1 of every 12 adult hospitalized patients with COVID-19. Pre-existing hypothyroidism in hospitalized patients with COVID-19 was not associated with higher disease severity or increased risk of mortality or ICU admissions. However, more research on the possible effects of COVID-19 on the thyroid gland and its function is needed in the future., (© 2022 John Wiley & Sons Ltd.) more...
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- 2024
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45. Surgical Scissors: The Core Surgical Instrument.
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Agarwal A, Jain A, Upadhyay A, and Deo N
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- Humans, Orthopedic Procedures instrumentation, Equipment Design, Biomechanical Phenomena, Surgical Instruments
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Surgical scissors form an essential part of both basic and specialty surgical sets. Their prime function is to cut tissues. They are also used for blunt dissection/development of tissue planes and piercing tissues. A wide variety of scissors are available for use in practice. This review article briefly describes common surgical scissors in orthopaedic use. The basic construct, biomechanics, types, their identification, specific uses, and care aspects are also discussed. A surgeon should be aware of the different types of scissors, their biomechanical features, and specific uses, as they are an important tool in his/her armamentarium. (Journal of Surgical Orthopaedic Advances 33(1):001-004, 2024). more...
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- 2024
46. Dry Eye Disease: An Overview of Its Risk Factors, Diagnosis, and Prevalence by Age, Sex, and Race.
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Deo N and Nagrale P
- Abstract
This short review focuses on the significance and prevalence of dry eye disease (DED) in the arena of ophthalmology. DED can be identified as one of the most common optical morbidities affecting about one-fourth of the patients visiting ophthalmology clinics. The perception of the cytology and disease evolution of DED has shown a noteworthy advancement in the last decade by recognizing two diverse mechanisms of the disease: tear desertion and deficient tear production. The role of these two components independently or concurrently in the prevalence of DED was also understood. Several studies in different parts of the world have projected that DED is more common in women as compared to men and this difference increases with ageing. Aged people, especially women in the menopausal and post-menopausal stages, are more prone to DED. This ailment is more prevalent in patients suffering from autoimmune diseases with a higher percentage of women getting affected. Various everyday activities as well as social and dietary behaviors like smoking might set off DED symptoms. Extensive visual tasking while using a computer, watching television, and doing a lot of reading also increase the risk of DED. Although DED occurs in all age groups, it is seen in very few children in comparison to adults. In fact, DED in children may be related to diverse factors such as congenial, inflammatory, and autoimmune disorders as well as environmental conditions and nutritional deficiencies. A significant relationship has also been found between DED and racial differences among individuals. A few studies have suggested that the Asian population is more susceptible to DED as compared to the Caucasian population, but this concept needs further research and investigation. Climatic conditions and environmental challenges, such as relative humidity (RH), internal atmosphere, effluence, travel by air, and intense temperatures, are equally important in the occurrence of DED. The present review aims to examine the prevalence of DED in relation to age, sex, and race by analyzing several relevant studies and also have an overview of the diagnosis and risk factors of the disease., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Deo et al.) more...
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- 2024
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47. Exploring complexity of class-A Beta-lactamase family using physiochemical-based multiplex networks.
- Author
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Bhadola P and Deo N
- Subjects
- Biological Evolution, Sequence Alignment, Amino Acids, beta-Lactamase Inhibitors, Anti-Bacterial Agents, beta-Lactamases metabolism, Proteins chemistry
- Abstract
The Beta-lactamase protein family is vital in countering Beta-lactam antibiotics, a widely used antimicrobial. To enhance our understanding of this family, we adopted a novel approach employing a multiplex network representation of its multiple sequence alignment. Each network layer, derived from the physiochemical properties of amino acids, unveils distinct insights into the intricate interactions among nodes, thereby enabling the identification of key motifs. Nodes with identical property signs tend to aggregate, providing evidence of the presence of consequential functional and evolutionary constraints shaping the Beta-lactamase family. We further investigate the distribution of evolutionary links across various layers. We observe that polarity manifests the highest number of unique links at lower thresholds, followed by hydrophobicity and polarizability, wherein hydrophobicity exerts dominance at higher thresholds. Further, the combinations of polarizability and volume, exhibit multiple simultaneous connections at all thresholds. The combination of hydrophobicity, polarizability, and volume uncovers shared links exclusive to these layers, implying substantial evolutionary impacts that may have functional or structural implications. By assessing the multi-degree of nodes, we unveil the hierarchical influence of properties at each position, identifying crucial properties responsible for the protein's functionality and providing valuable insights into potential targets for modulating enzymatic activity., (© 2023. The Author(s).) more...
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- 2023
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48. Iatrogenic Demodex folliculitis: A case report.
- Author
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Deo N, Isaq NA, Peters MS, and Link J
- Subjects
- Humans, Animals, Female, Middle Aged, Skin pathology, Iatrogenic Disease, Mite Infestations diagnosis, Mite Infestations drug therapy, Mite Infestations complications, Folliculitis diagnosis, Folliculitis drug therapy, Folliculitis etiology, Mites
- Abstract
Demodex folliculorum is a commensal mite that inhabits the orifices of cutaneous pilosebaceous follicles. Overgrowth of these organisms can lead to Demodex folliculitis, which typically presents as papules and pustules predominantly involving the temples, cheeks, and occasionally the chest. We present a 51-year-old woman with iatrogenic Demodex folliculitis secondary to immunosuppressive treatment for an autoimmune connective tissue disease. Histopathological exam of a skin biopsy, which revealed follicular Demodex mites, confirmed the diagnosis. The eruption was treated with oral ivermectin and topical metronidazole gel, and the patient's immunosuppressive regimen was decreased, resulting in marked improvement in the eruption within 6 weeks and no worsening of her underlying autoimmune disorder. This case emphasizes the importance of considering Demodex folliculitis in the differential diagnosis of a new onset rash in the context of immunosuppressive treatment., (© 2023 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.) more...
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- 2023
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49. Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis.
- Author
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Siddiqui H, Deo N, Rutledge MT, Williams MJA, Redpath GMI, and McCormick SPA
- Subjects
- Humans, Lipoprotein(a) metabolism, Dextrans metabolism, Phosphatidylinositol 3-Kinases metabolism, Carrier Proteins, Apolipoproteins A metabolism, Plasminogen chemistry, Plasminogen metabolism, Annexin A2 genetics
- Abstract
Background: High levels of Lp(a) (lipoprotein(a)) are associated with multiple forms of cardiovascular disease. Lp(a) consists of an apoB
100 -containing particle attached to the plasminogen homologue apo(a). The pathways for Lp(a) clearance are not well understood. We previously discovered that the plasminogen receptor PlgRKT (plasminogen receptor with a C-terminal lysine) promoted Lp(a) uptake in liver cells. Here, we aimed to further define the role of PlgRKT and to investigate the role of 2 other plasminogen receptors, annexin A2 and S100A10 (S100 calcium-binding protein A10) in the endocytosis of Lp(a)., Methods: Human hepatocellular carcinoma (HepG2) cells and haploid human fibroblast-like (HAP1) cells were used for overexpression and knockout of plasminogen receptors. The uptake of Lp(a), LDL (low-density lipoprotein), apo(a), and endocytic cargos was visualized and quantified by confocal microscopy and Western blotting., Results: The uptake of both Lp(a) and apo(a), but not LDL, was significantly increased in HepG2 and HAP1 cells overexpressing PlgRKT, annexin A2, or S100A10. Conversely, Lp(a) and apo(a), but not LDL, uptake was significantly reduced in HAP1 cells in which PlgRKT and S100A10 were knocked out. Surface binding studies in HepG2 cells showed that overexpression of PlgRKT, but not annexin A2 or S100A10, increased Lp(a) and apo(a) plasma membrane binding. Annexin A2 and S100A10, on the other hand, appeared to regulate macropinocytosis with both proteins significantly increasing the uptake of the macropinocytosis marker dextran when overexpressed in HepG2 and HAP1 cells and knockout of S100A10 significantly reducing dextran uptake. Bringing these observations together, we tested the effect of a PI3K (phosphoinositide-3-kinase) inhibitor, known to inhibit macropinocytosis, on Lp(a) uptake. Results showed a concentration-dependent reduction confirming that Lp(a) uptake was indeed mediated by macropinocytosis., Conclusions: These findings uncover a novel pathway for Lp(a) endocytosis involving multiple plasminogen receptors that enhance surface binding and stimulate macropinocytosis of Lp(a). Although the findings were produced in cell culture models that have limitations, they could have clinical relevance since drugs that inhibit macropinocytosis are in clinical use, that is, the PI3K inhibitors for cancer therapy and some antidepressant compounds., Competing Interests: Disclosures None. more...- Published
- 2023
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50. Discharge Disposition and Loss of Independence Among Survivors of COVID-19 Admitted to Intensive Care: Results From the SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS).
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Siddiqui S, Kelly L, Bosch N, Law A, Patel LA, Perkins N, Armaignac DL, Zabolotskikh I, Christie A, Krishna Mohan S, Deo N, Bansal V, Kumar VK, Gajic O, Kashyap R, Domecq JP, Boman K, Walkey A, Banner-Goodspeed V, and Schaefer MS more...
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- Adult, Humans, Aged, Patient Discharge, Critical Care, Hospitalization, Intensive Care Units, Survivors, COVID-19
- Abstract
Objectives: To describe incidence and risk factors of loss of previous independent living through nonhome discharge or discharge home with health assistance in survivors of intensive care unit (ICU) admission for coronavirus disease 2019 (COVID-19)., Design: Multicenter observational study including patients admitted to the ICU from January 2020 till June 30, 2021., Hypothesis: We hypothesized that there is a high risk of nonhome discharge in patients surviving ICU admission due to COVID-19., Setting: Data were included from 306 hospitals in 28 countries participating in the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 registry., Patients: Previously independently living adult ICU survivors of COVID-19., Interventions: None., Measurements and Main Results: The primary outcome was nonhome discharge. Secondary outcome was the requirement of health assistance among patients who were discharged home. Out of 10 820 patients, 7101 (66%) were discharged alive; 3791 (53%) of these survivors lost their previous independent living status, out of those 2071 (29%) through nonhome discharge, and 1720 (24%) through discharge home requiring health assistance. In adjusted analyses, loss of independence on discharge among survivors was predicted by patient age ≥ 65 years (adjusted odds ratio [aOR] 2.78, 95% confidence interval [CI] 2.47-3.14, P < .0001), former and current smoking status (aOR 1.25, 95% CI 1.08-1.46, P = .003 and 1.60 (95% CI 1.18-2.16), P = .003, respectively), substance use disorder (aOR 1.52, 95% CI 1.12-2.06, P = .007), requirement for mechanical ventilation (aOR 4.17, 95% CI 3.69-4.71, P < .0001), prone positioning (aOR 1.19, 95% CI 1.03-1.38, P = .02), and requirement for extracorporeal membrane oxygenation (aOR 2.28, 95% CI 1.55-3.34, P < .0001)., Conclusions: More than half of ICU survivors hospitalized for COVID-19 are unable to return to independent living status, thereby imposing a significant secondary strain on health care systems worldwide. more...
- Published
- 2023
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