3 results on '"Dinh Phu Vu"'
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2. Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial
- Author
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Dadang Hudaya Somasetia, Lu Viet Ho, Jeremy Farrar, Elizabeth Higgs, Walter Rj Taylor, Pham Phuong Bui, Iko Safika, Yong Rongrungruang, Elaine Stockwell, Tan Thanh Tran, Niklas Lindegardh, Thanh Phong Nguyen, Thi Thuy Chinh Bkrong Nguyen, Quoc Chinh Luong, Nguyen Truc Nhu Le, Van Kinh Nguyen, Umaporn Chantbuddhiwet, Thi Thu Thao Le, Arto Yuwono Soeroto, Quoc Bao Vo, Winai Ratanasuwan, Sri Sudarwati, Kasia Stepniewska, Thi Thanh Dang, Quang Ha Do, Kulkanya Chokephaibulkit, Nicholas P. J. Day, Laura Merson, Thuy Ngan Tran, Chareon Chuchottaworn, Ngoc Quang Minh Ngo, H. Rogier van Doorn, Frederick G. Hayden, Anh Tuan Tran, Sondang Maryutka Sirait, Steve Wignall, Michael Polis, Moh Suhud Malik, Menno D. de Jong, Wasana Prasitsuebsai, Phuong Khanh Vo, Adria Rusli, Nguyen Nhat Trung Le, Prijanti Z Soepandi, Huu Khanh Truong, Paul A. Tambyah, Anh Tuan Le, Quynh Huong Tran, Tjandra Yoga Aditama, Thi Ngoc Anh Tran, Yee Sin Leo, Rismali Agus, Patama Sutha, Thi San Luong, Thi Tam Duong, Xuan Vu Bui, Vinh Diet Tran, Quoc Thai Nguyen, Tinh Hien Tran, Thanh Liem Nguyen, Thi Tam Cao, Endang Rahayu Sedyaningsih, Tawee Chotpitayasunondh, Thi Ty Hang Vu, Lawrence Lee, An Nguyet Lam, Hong Nhien Trinh, Piamlarp Sansayunh, Ngoc Tu Anh Nguyen, My Ngoc Nghiem, Thi Thanh Ha Nguyen, Weerawat Manosuthi, Thi Tam Uyen Le, Tini T Maskoen, Viet Hung Pham, Annette Fox, Piyarat Suntarattiwong, Supichaya Netsawang, Thi Hai Men Pham, Thi Hai Ninh Tran, Heiman L Wertheim, Xuan Ngoc Le, Thu Hien Pham, Ida Parwati, Juliet E. Bryant, C. Fukuda, Ngoc Phuc Nguyen, Dewi Murniati, Louis Yi Ann Chai, Phan Kim Thoa Le, Minh Hien Vo, Thi Hanh Le Nguyen, Van Hao Nguyen, Chau Viet Do, Yovita Hartantri, Quoc Thinh Le, Nirun Vanprapar, Vu Huy Bui, Nicholas J. White, Viet Tung Cao, Orasri Wittawatmongkol, Djatnika Setiabudi, Thi Tham Nguyen, Thi Kim Thoa Ho, Trung Cap Nguyen, Vivi Setiawaty, Duy Khuong Huynh, Thi Mai Thanh Doan, Thi Thu Loan Tran, Viet Hung Dau, Huu Phuc Phan, Thi Thuy Ha Lam, Hadi Jusuf, Hong Ha Nguyen, Vu Nguyen, Van Tuyet Hoang, Agung P Sutiyoso, Thi My Dung Tran, Ika Priatni, Sila Wiweka, Sardikin Giriputro, Emmy Hermiyanti Pranggono, Anh Tuan Ho, Pilaipan Puthavathana, Kevin Baird, Erlina Burhan, Binh Bao Tinh Le, Kittima Bangpattanasiri, Thanomsak Anekthananon, Chariya Sangsajja, Sri Sulastri, Dale A. Fisher, Minh Qui Le, Peter Horby, Manh Tuan Ha, Raymond T. P. Lin, Trihono Trihono, Chau Thy Tieu, Thi Thuy Tran, Duc Hien Nguyen, Tu Qui Phan, Tran Dieu Hien Pham, Thanh Truong Nguyen, Dinh Phu Vu, Van Vinh Chau Nguyen, Tony Soetanto, John H. Beigel, Lia G Partakusuma, AII - Amsterdam institute for Infection and Immunity, and Medical Microbiology and Infection Prevention
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Administration, Oral ,Severity of Illness Index ,law.invention ,chemistry.chemical_compound ,0302 clinical medicine ,Clinical Protocols ,Randomized controlled trial ,law ,Medicine ,030212 general & internal medicine ,Child ,Singapore ,0303 health sciences ,Reverse Transcriptase Polymerase Chain Reaction ,virus diseases ,General Medicine ,Middle Aged ,Thailand ,3. Good health ,Hospitalization ,Treatment Outcome ,medicine.anatomical_structure ,Vietnam ,Influenza A virus ,Practice Guidelines as Topic ,Adult ,Oseltamivir ,medicine.medical_specialty ,Severe influenza ,Antiviral Agents ,Double blind ,03 medical and health sciences ,Double-Blind Method ,Throat ,Internal medicine ,Influenza, Human ,Humans ,In patient ,Dose-Response Relationship, Drug ,030306 microbiology ,business.industry ,Double dose ,Infant ,Hemagglutination Inhibition Tests ,Clinical trial ,Influenza B virus ,chemistry ,Indonesia ,business - Abstract
Objective To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza. Design Double blind randomised trial. Setting Thirteen hospitals in Indonesia, Singapore, Thailand, and Vietnam. Participants Patients aged ≥1 year admitted to hospital with confirmed severe influenza. Interventions Oral oseltamivir at double dose (150 mg twice a day/paediatric equivalent) versus standard dose (75 mg twice a day/paediatric equivalent). Main outcome measure Viral status according to reverse transcriptase polymerase chain reaction (RT-PCR) for influenza RNA in nasal and throat swabs on day five. Results Of 326 patients (including 246 (75.5%) children aged
- Published
- 2016
3. Effectiveness of Continuous Endotracheal Cuff Pressure Control for the Prevention of Ventilator-Associated Respiratory Infections: An Open-Label Randomized, Controlled Trial.
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Dat VQ, Minh Yen L, Thi Loan H, Dinh Phu V, Thien Binh N, Geskus RB, Khanh Trinh DH, Hoang Mai NT, Hoan Phu N, Huong Lan NP, Phuong Thuy T, Vu Trung N, Trung Cap N, Tuyet Trinh D, Thi Hoa N, Thi Thu Van N, Luan VTT, Quynh Nhu TT, Bao Long H, Thanh Ha NT, Thi Thanh Van N, Campbell J, Ahmadnia E, Kestelyn E, Wyncoll D, Thwaites GE, Van Hao N, Chien LT, Van Kinh N, Vinh Chau NV, van Doorn HR, Thwaites CL, and Nadjm B
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- Humans, Intubation, Intratracheal adverse effects, Length of Stay, Ventilators, Mechanical, Pneumonia, Ventilator-Associated epidemiology, Pneumonia, Ventilator-Associated microbiology, Pneumonia, Ventilator-Associated prevention & control, Respiratory Tract Infections epidemiology, Respiratory Tract Infections prevention & control
- Abstract
Background: An endotracheal tube cuff pressure between 20 and 30 cmH2O is recommended to prevent ventilator-associated respiratory infection (VARI). We aimed to evaluate whether continuous cuff pressure control (CPC) was associated with reduced VARI incidence compared with intermittent CPC., Methods: We conducted a multicenter open-label randomized controlled trial in intensive care unit (ICU) patients within 24 hours of intubation in Vietnam. Patients were randomly assigned 1:1 to receive either continuous CPC using an automated electronic device or intermittent CPC using a manually hand-held manometer. The primary endpoint was the occurrence of VARI, evaluated by an independent reviewer blinded to the CPC allocation., Results: We randomized 600 patients; 597 received the intervention or control and were included in the intention to treat analysis. Compared with intermittent CPC, continuous CPC did not reduce the proportion of patients with at least one episode of VARI (74/296 [25%] vs 69/301 [23%]; odds ratio [OR] 1.13; 95% confidence interval [CI] .77-1.67]. There were no significant differences between continuous and intermittent CPC concerning the proportion of microbiologically confirmed VARI (OR 1.40; 95% CI .94-2.10), the proportion of intubated days without antimicrobials (relative proportion [RP] 0.99; 95% CI .87-1.12), rate of ICU discharge (cause-specific hazard ratio [HR] 0.95; 95% CI .78-1.16), cost of ICU stay (difference in transformed mean [DTM] 0.02; 95% CI -.05 to .08], cost of ICU antimicrobials (DTM 0.02; 95% CI -.25 to .28), cost of hospital stay (DTM 0.02; 95% CI -.04 to .08), and ICU mortality risk (OR 0.96; 95% CI .67-1.38)., Conclusions: Maintaining CPC through an automated electronic device did not reduce VARI incidence., Clinical Trial Registration: NCT02966392., (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Published
- 2022
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