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5. Don't Be a Waster! Student Perceptions of Recycling Strategies at an English University's Halls of Residence

Author

Dixon, Joseph and Parker, Jonathan

Abstract

Purpose: This paper aims to explore student perceptions of recycling and explore whether one university's strategy helped or hindered student recycling in their university's halls of residence. There is near-universal acknowledgement of the urgency of the climate crisis, yet household recycling rates remain low at 45.2%. Student-recycling rates have been suggested to be even lower. After a brief consideration of the recent history of sustainability and recycling, this paper identifies the actions required to increase student recycling, including peer influence, education and information, physical structures and attitudes and motivations. Design/methodology/approach: Twelve in-depth, semi-structured interviews were undertaken at one Southern English university. The rich, qualitative data obtained were then analysed thematically. The theory of environmentally significant behaviour provided a framework for understanding perceptions and behaviours in that site. Findings: Confirming aspects of existing literature, students' recycling behaviours were found to be limited through lack of perceived ability, lack of facilities and unconfident knowledge. Students were also found to be limiting their own actions. A holistic approach including peer influence, education and information, physical structures and attitudes and motivations was recommended. Originality/value: There is little research into student recycling behaviours and limited literature concerning halls of residence, especially in the UK. This paper draws on one case to add to nascent understandings. While limited to one site and by sample size, a number of recommendations are made, covering university facilities, student empowerment and individual responsibility to increase future recycling.

Published
2022
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8. Increasing the saturation of BET inhibitors

Author

Dixon, Joseph Edward, Watson, Allan, and Wellaway, Chris

Abstract

Bromodomains are epigenetic reader modules that are found as part of multidomain proteins. They recognise acetylated lysine residues on histone tails in order to regulate gene expression. Bromodomain and extra-terminal domain (BET) proteins are a family of bromodomain-containing proteins that consist of BRD2, BRD3, BRD4 and BRDT. Each of these contains the tandem bromodomain modules, BD1 and BD2. BET proteins are an interesting target for drug discovery that has emerged in recent years, with numerous pan-BET inhibitors being reported to have anti-inflammatory and anti-proliferative properties. A chemoinformatic analysis has demonstrated that, compared to approved drugs, reported BET inhibitors had relatively low three-dimensional character.1 In other words, they are highly unsaturated, flat molecules. The relevance of this is explained in the "Escape from Flatland" papers, wherein empirical analysis demonstrated that drug candidates with a higher degree of saturation are likely to be less promiscuous, more soluble and overall be more likely to succeed to market.2,3 This research set out to develop a series of pan-BET inhibitors with an increased degree of saturation to those existing in the literature. The approach taken involved replacing a phenyl ring in a well-established inhibitor fragment with a saturated analogue, and exploring the vectors produced. During this process a molecule was discovered that had unexpected selectivity for the BD2 domain of BRD4 over the BD1 domain. There are very few published examples of BD2-selective BET inhibitors, and as a result there is limited understanding of how the biological roles of BD2 domains differ from their BD1 counterparts. Therefore, the direction of this project was altered in order to try and understand the source of this observed selectivity, and rationally improve upon it. Target compounds were designed to probe which amino acid residue differences were responsible for the selectivity, and from this a hypothesis was generated. The end result was a lead compound with three stereocentres around a piperidine framework, sub-micromolar potency, and over twice the level of BD2-selectivity at BRD4 of any compounds reported to date. This compound, and the approach taken to discover it, represents an important contribution to the art and provides a basis for further investigations in this scientific field.

Published
2018
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9. The UK foot and ankle COVID-19 national (FAlCoN) audit – Regional variations in COVID-19 infection and national foot and ankle surgical activity

Author

Harb, Ziad, Richardson, Ruth, Gadd, Richard, Kerr, Alexander, Clay, William, Mallick, Arijit, Bhargava, Amit, Tiruveedhula, Madhu, Walls, Andrew, O'Flaherty, Maurice, Craig, Julie, Dawson, Daniel, McCaughey, Philip, Crean, Jonathan, Ayyasamy, Brijesh, Prasad, Pradeep, Ansnd, Anoop, Tarar, Yasir, Choo, Xin Yin, Yousufuddin, Shaik, Stone, Andrew, Amer, Mohammed, Haarer, Francesca, Barrow, Tom, Singh, Vishwajeet, Junaid, Sayani, Houssain, Natasha, Dhukaram, Vivek, Elbayyouk, Khalil, Abiddin, Zain ul, Salih, Samir, Fong, Angus, Arora, Abhishek, Louette, Luc, Faria, Giles, Smith, Andrew, Aithal, Shivashanker, Palihawadana, Dhanushka, Pir-Siahbazy, Ramtin, Zubairy, Aamir, Rose, Barry, McCormack, Annie, Vega-Poblete, Maira, Wahed, Karim, Malik, Khalid, Yousaf, Sohail, Sott, Andrea, Evangelidis, Dimosthenis, Hamilton, Paul, Abbott, Sarah, Naraen, Akarshan, Syed, Turab A, Benjamin, Biju, Ferreira, Catarina, Drampalos, Efstathios, Dasari, Kishore Kumar, Galhoum, Ahmed, Marsland, Daniel, Elliot, Robin, Chowdhury, Alex, Tareef, Tareq, Salim, Javed, Mishra, Viren, Amanat, Suheil, Ray, Robbie, Kavarthapu, Venu, Ahluwalia, Raju, Shah, Rohi, Lyle, Shirley, Molloy, Andy, Currall, Verity, Hatzantonis, Catherine, Dixon, Joseph, Goff, Thomas, Eyre, Jason, Kheir, Ehab, Haendlmayer, Kurt, Demoulin, Erin, Ali, Zulfikar, Loughenbury, Faye, Mansoor, Sufyan, Butcher, Alexander, Bonner, Rory, Saha, Anamika, Mcknight, Gareth Ewan, Lokanathan, Prashan, Lees, Rupert, Harrison, Peter, Kelly, Andrew, Macdonald, Hamish, Slade, George, Clayton, Robert, Middleton, Scott, Oag, Erlend, Loveday, David T, Atkinson, Henry, Dalrymple, James, Zaveri, Amit, Jani, Priya, Fernandes, Ramon, Johnson-Lynn, Sarah, Robertson-McPartlin, Lynne, Alderton, Elizabeth, Townshend, Dave, Porter, Anna, McLaughlin, Nicole, Guiguis, John, Kurup, Harish, Vasukutty, Nijil, Wokhlu, Ashim, Ogunsola, Abidemi, Koc, Togay, Hodkinson, Simon, Jowett, Billy, Shamoon, Samer, Mustafa, Qamar, Stoneham, Adam, Duggleby, Luke, Teoh, Kar, Ali, Shahahoor, Islam, Raisa, Butler, Mike, Brennan, Ciaran, Jennison, Toby, Karim, Tariq, Milner, Stephen, Mishra, Arya, Singh, Hemant, Haldar, Anil, Budair, Basil, MacKenzie, James, Dong, Huan, Prem, Hari, Wall, Rosemary, Dawe, Edward, Sexton, Sarah, O'Dowd-Booth, Christopher, Azeez, Sadeeq, Mavromatidou, Galini, Topliss, Claire, Makwana, Nilesh, Dass, Debashis, Abas, Sameera, Cheruvu, Manikandar Srinivas, Devany, Adam, Ieong, Edmund, Rudge, Ben, Kane, Prathamesh, Guha, Abhijit, Suen, Eric Ho Ming, Eldessouky, Amr, Saad, Ahmed Isam, Ali, Ibrahim, Hickey, Benjamin, Pillai, Anand, Islam, Amirul, Akbar, Zeeshan, Naylor, Tom, Khan, Umair, Jowett, Charlie, Mahmoud, Mohamed, Cryer, Gunay, Place, Stuart, Mason, Lyndon W, Malhotra, Karan, Houchen-Wollof, Linzy, and Mangwani, Jitendra

Published
2022
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12. Early years postgraduate surgical training programmes in the UK are failing to meet national quality standards: An analysis from the ASiT/BOTA Lost Tribe prospective cohort study of 2,569 surgical trainees

Author

Glasbey, James C., Harries, Rhiannon L., Beamish, Andrew J., Gokani, Vimal J., Mohan, Helen, Williams, Adam P., Fleming, Simon, Chai, Aaron, Singh, Abhinav, Stoneham, Adam C.S., Lunt, Adam J., Rehman, Adeeb H., Dhahri, Adeel A., Yvon, Adrien R.A., Dutta, Agneish, Abou-Foul, Ahmad K., Abdelrahman, Ahmed, Daoub, Ahmed, Sanalla, Ahmed, de Gea Rico, Aitor, Konarski, Alastair, Ward, Alex E., Wilkin, Alex J., Winter, Alexandra K., Arnaout, Ali, Bakhsh, Ali, Esfandiari, Alireza, Hardy, Alistair W., Khan, Amad N., Thacoor, Amitabh, Gavrila, Ana D., Nedea, Anca-Mihaela, Fontalis, Andreas, Hall, Andrew J., Williamson, Andrew J., Kosti, Angeliki, Harlinska, Anna, Adimonye, Anthony, Egglestone, Anthony, Thaventhiran, Anthony J., Myatt, Antonia, Vusirikala, Anuhya, Rawashdeh, Arab S., Paramasivan, Arjun C., Cotton, Arthur E., Scrimshire, Ashley B., Ramesh, Ashwanth C., Krishnamoorthy, Ashwin K., Ahmed, Asif, Abdul-Hamid, Ayeshah, Khan, Ayushah, Oremule, Babatunde, Ho, Beatrice, Barkham, Ben, Collard, Ben, Edgar, Ben F., Drake, Benjamin, John, Bethan E., Gordon, Catherine R., Rossborough, Catherine, Park, Chang Y., Seretis, Charalampos, Johnson, Charles H.N., Gill, Charn, Serino, Chiara, Ogbuokiri, Chinomso I., Swords, Chloe, Kang, Chong Y., McKinnon, Chris, Brown, Christopher E., Manning, Christopher J., Marusza, Christopher J., Jones, Christopher P., Forde, Cillian T., Wilson, Claire L., Koh, Claudia, Horgan, Conal, Lin, Daniel J., Ashmore, Daniel L., Ness, Daniel, Akhtar, Daniel O., Doherty, Daniel T., Scholfield, Daniel W., Ensor, David C., Bratt, David G., Spence, David J.R., Thomson, David R., Ferguson, David W., Apparau, Denish, Navaratnam, Devaraj M., Mai, Dinh, Rutherford, Duncan G., Karam, Edward, Wu, Eiling, Zimmermann, Eleanor F., Douka, Eleftheria, Flatt, Elinor, Kane, Elizabeth G., Thornhill, Elizabeth L., Gammeri, Emanuele, Littlehales, Emma G., Valsamis, Epaminondas M., Hankin, Erin J., Meenan, Erin R.M., Botha, Etienne N., Khalid, Farhan, Patel, Fatema, Power, Fiachra R., Rutherford, Fiona M., Saeed, Fozia, Guest, Francesca L., Barbosa, Francisco J., Cameron, Fraser G., Raja, Furqan R., Thiruchandran, Gajendiran, Munbauhal, Gavish, Dovey, Gemma E., Hogg, Gemma E., Dovell, George E., Matheron, George, Hill, George T., Layton, Georgia R., Jong, Georgiana G.S., Hicks, Georgina, Millward, Graham J., Shaw, Grahame A., Stamp, Gregory F.W., Parwaiz, Hammad, Chong, Han Hong, Copley, Hannah C., Lennox-Warburton, Hannah C., Emerson, Hannah M., Dean, Harry F., Eltyeb, Hazim, Chu, Howard O., Sadien, Iannish, Mohamed, Imran M., Parwaiz, Iram, Drummond, Isabella M.H., Pearce, Jack C.H., Ahmed, Jacob J., Koris, Jacob, Rait, Jaideep S., Bailey, James A., Cohen, James A., Kennedy, James A., Olivier, James B., Bailey, James, Archer, James E., Stewart, James J., de Barros, James N.J.Monteiro, Allen, James R., O'Brien, James W., James, McGhee, T., Quarcoopome, Jared N., Winyard, Jasmine C., Roberts, Jason L., Barwell, Jennifer S., Rodrigues, Jeremy, Chapman, Jessica A.R., Fairbanks, Jessica Y., Voll, Jessika, Lim, Jie Q., Chang, Jin H., Bovis, Joanna L., Ferns, John, Tam, Johnson Pok Him, Herron, Jonathan B.T., Macdonald, Jonathan D.R., Ducey, Jonathan R., DIxon, Joseph W., Luck, Joshua T., Hewage, Kalon, Yakoub, Kamal M., Bhopal, Kamran F., Vejsbjerg, Karen A., Aboelmagd, Karim, Bera, Katarzyna D., Hamlett, Katharine E., Fok, Katherine E., Hurst, Katherine V., Gillams, Kathryn L., Siggens, Katie L., Young, Katie, Burns, Kenneth M., Burke, Kerry A., Seebah, Kevin, Shah, Khalid A., Bentick, Kieran R., Majid, Kiran, Davies, Kirsty L., Tan, Krystal, Baryeh, Kwaku W., Phillips, Laura A.F., Ellerton, Laura N., Giet, Leeying J., Monaghan, Liam, Ka Cheung, Lok, Shen, Louise L., Paramore, Louise, Arrowsmith, Lucy J., Attwell, Lukas A., Thornton, Luke, Xu, Luting, Leadon, Madeline L., Natarajan, Madhavi, Houlihan, Maria C.R., Cheah, Marisa, Sagmeister, Markus L., Abubakar, Maryam, Flynn, Matthew F., Harris, Matthew, Stone, Matthew J., Young, Matthew J., Gray, Matthew P., Horner, Matthew P., Schembri, Matthew, Trail, Matthew, Joy, Melvin, Rice, Michael J., Thomas, Michael P., Poon, Michael T.C., Stoddart, Michael T., Fong, Michelle L., Foster, Mitchell T., Mohamud, Mohamed F., Hoque, Mohammed N., Remtulla, Mohammedabbas, Javed Karim, Mohsin, Rezacova, Monika, Siddiqui, Muhammad B., Iqbal, Muhammad R., Mensa, Mussa, McCauley, Nadine, Bauer, Natasha J., Walker, Nathan, Hakim, Navid A., Knight, Ngonidzashe, O'Hara, Niall, Fawcett, Nicholas A., Wong, Nicholas, Allen, Nicola F.D., Husnoo, Nilofer, Vallabh, Nimisha, Srikandarajah, Nisaharan, Chidumije, Nnaemeka, Elamin, Obaiy, Akinlaja, Odunayo O., Griffiths, Olga, Brown, Oliver D., Shastri, Oliver, Cameron, Olivia J., Kenyon, Olivia, Javed, Omar A., Sogaolu, Opeyemi O., Birmpili, Panagiota, Haylock-Vize, Patricia, Green, Patrick A., Carroll, Patrick J., Yang, Peiming, Beak, Philip, Persson, Pia, Tam, Pok Him Johnson, Waqar, Rabia, Morley, Rachael L., Bowden, Rachel Clare, Eyre, Rachel L., Pankhania, Rahul M., Sahemey, Rajpreet S., Kabariti, Rakan, Rawashdeh, M., Arab, Rawashdeh S., Rollett, Rebecca A., Nicholas, Rebecca S., Morgan, Rebecca V., Limb, Richard, Robinson, Richard Mark, Hayes, Richard S., Daureeawoo, Ridwan, Cooke, Robert A., Espey, Robert A.J., Chessman, Robert, Whitham, Robert D.J., Payne, Robert E., Staruch, Robert, Alho, Roberto J.R., Gordon, Robin, Cuthbert, Rory, Harrison, Roseanna B., Scott, Rupert A., Parks, Ruth M., Cheong, Ryan C.T., Hillier-Smith, Ryan L., Moffatt, Ryan, Rehman, Saad, Ambren, Sabah, Abdulal, Sabria, Kulkarni, Sagar, Hopwood, Sam, Greenfield, Samantha H., Mehta, Samir K., Haines, Samuel, AlSaati, Sarah A., Williams, Sarah A., El-Badawy, Sarah, Barlow, Sarah L., Pywell, Sarah, Pollock, Sarah-jayne, Lampridis, Savvas, Nazarian, Scarlet, Rezvani, Sean, Scattergood, Sean, Toescu, Sebastian M., Hotonu, Sesi, Shaikh, Shafaque, Rupani, Shamil, Hasan, Shumaila, Pradeep, Shwetha, Cole, Simon J., Growcott, Siona A., Bedoya, Sofia E., Ike, Sonia I., Bodnarescu, Stefan V., Seppings, Stella C., Poyntz, Stephanie A., Jordan, Stevan J., Iqbal, Sundas, Das, Suparna, Chatterjee-Woolman, Suravi, Shumon, Syed, Morrison, Tamsin E.M., Sibartie, Tara, Aboelmagd, Tariq, Russell, Thomas B., Seddon, Thomas C., Stringfellow, Thomas D., Goldsmith, Thomas, Banks, Thomas H.F., Tolley, Thomas, Oputa, Tobenna J., Kanzara, Todd T., Challoner, Tom, Urbonas, Tomas, Richards, Tomos B., Morrison-Jones, Victoria J., Garikapati, Vivek, Al-Azzani, Waheeb A.K., Zahra, Wajiha, Ho, Weiguang, Al-Dhahir, Wesam, Gibson, William G.W., Grant, Yasmin, Hijazi, Yasser, Chiang, Yayganeh, Gundkalli, Zobia K., Seymour, Zoe M., and Panayi, Zoe

Published
2018
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14. Where To Watch ' Halloween Ends' (Free) Online Streaming at Home Here's How

Author

Dixon, Joseph

Subjects
African American Studies, Arts and Humanities, Race, Ethnicity and Post-Colonial Studies
Abstract

‘Halloween Ends’: How to Watch The Final Installment of the Slasher Series Online Halloween Ends will arrive on Peacock on Oct. 14. Here's how to watch the final installment of the slasher series online.

Published
2022
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16. The UK foot and ankle COVID-19 national (FAlCoN) audit – Regional variations in COVID-19 infection and national foot and ankle surgical activity

Author

Mason, Lyndon W, primary, Malhotra, Karan, additional, Houchen-Wollof, Linzy, additional, Mangwani, Jitendra, additional, Harb, Ziad, additional, Richardson, Ruth, additional, Gadd, Richard, additional, Kerr, Alexander, additional, Clay, William, additional, Mallick, Arijit, additional, Bhargava, Amit, additional, Tiruveedhula, Madhu, additional, Walls, Andrew, additional, O'Flaherty, Maurice, additional, Craig, Julie, additional, Dawson, Daniel, additional, McCaughey, Philip, additional, Crean, Jonathan, additional, Ayyasamy, Brijesh, additional, Prasad, Pradeep, additional, Ansnd, Anoop, additional, Tarar, Yasir, additional, Choo, Xin Yin, additional, Yousufuddin, Shaik, additional, Stone, Andrew, additional, Amer, Mohammed, additional, Haarer, Francesca, additional, Barrow, Tom, additional, Singh, Vishwajeet, additional, Junaid, Sayani, additional, Houssain, Natasha, additional, Dhukaram, Vivek, additional, Elbayyouk, Khalil, additional, Abiddin, Zain ul, additional, Salih, Samir, additional, Fong, Angus, additional, Arora, Abhishek, additional, Louette, Luc, additional, Faria, Giles, additional, Smith, Andrew, additional, Aithal, Shivashanker, additional, Palihawadana, Dhanushka, additional, Pir-Siahbazy, Ramtin, additional, Zubairy, Aamir, additional, Rose, Barry, additional, McCormack, Annie, additional, Vega-Poblete, Maira, additional, Wahed, Karim, additional, Malik, Khalid, additional, Yousaf, Sohail, additional, Sott, Andrea, additional, Evangelidis, Dimosthenis, additional, Hamilton, Paul, additional, Abbott, Sarah, additional, Naraen, Akarshan, additional, Syed, Turab A, additional, Benjamin, Biju, additional, Ferreira, Catarina, additional, Drampalos, Efstathios, additional, Dasari, Kishore Kumar, additional, Galhoum, Ahmed, additional, Marsland, Daniel, additional, Elliot, Robin, additional, Chowdhury, Alex, additional, Tareef, Tareq, additional, Salim, Javed, additional, Mishra, Viren, additional, Amanat, Suheil, additional, Ray, Robbie, additional, Kavarthapu, Venu, additional, Ahluwalia, Raju, additional, Shah, Rohi, additional, Lyle, Shirley, additional, Molloy, Andy, additional, Currall, Verity, additional, Hatzantonis, Catherine, additional, Dixon, Joseph, additional, Goff, Thomas, additional, Eyre, Jason, additional, Kheir, Ehab, additional, Haendlmayer, Kurt, additional, Demoulin, Erin, additional, Ali, Zulfikar, additional, Loughenbury, Faye, additional, Mansoor, Sufyan, additional, Butcher, Alexander, additional, Bonner, Rory, additional, Saha, Anamika, additional, Mcknight, Gareth Ewan, additional, Lokanathan, Prashan, additional, Lees, Rupert, additional, Harrison, Peter, additional, Kelly, Andrew, additional, Macdonald, Hamish, additional, Slade, George, additional, Clayton, Robert, additional, Middleton, Scott, additional, Oag, Erlend, additional, Loveday, David T, additional, Atkinson, Henry, additional, Dalrymple, James, additional, Zaveri, Amit, additional, Jani, Priya, additional, Fernandes, Ramon, additional, Johnson-Lynn, Sarah, additional, Robertson-McPartlin, Lynne, additional, Alderton, Elizabeth, additional, Townshend, Dave, additional, Porter, Anna, additional, McLaughlin, Nicole, additional, Guiguis, John, additional, Kurup, Harish, additional, Vasukutty, Nijil, additional, Wokhlu, Ashim, additional, Ogunsola, Abidemi, additional, Koc, Togay, additional, Hodkinson, Simon, additional, Jowett, Billy, additional, Shamoon, Samer, additional, Mustafa, Qamar, additional, Stoneham, Adam, additional, Duggleby, Luke, additional, Teoh, Kar, additional, Ali, Shahahoor, additional, Islam, Raisa, additional, Butler, Mike, additional, Brennan, Ciaran, additional, Jennison, Toby, additional, Karim, Tariq, additional, Milner, Stephen, additional, Mishra, Arya, additional, Singh, Hemant, additional, Haldar, Anil, additional, Budair, Basil, additional, MacKenzie, James, additional, Dong, Huan, additional, Prem, Hari, additional, Wall, Rosemary, additional, Dawe, Edward, additional, Sexton, Sarah, additional, O'Dowd-Booth, Christopher, additional, Azeez, Sadeeq, additional, Mavromatidou, Galini, additional, Topliss, Claire, additional, Makwana, Nilesh, additional, Dass, Debashis, additional, Abas, Sameera, additional, Cheruvu, Manikandar Srinivas, additional, Devany, Adam, additional, Ieong, Edmund, additional, Rudge, Ben, additional, Kane, Prathamesh, additional, Guha, Abhijit, additional, Suen, Eric Ho Ming, additional, Eldessouky, Amr, additional, Saad, Ahmed Isam, additional, Ali, Ibrahim, additional, Hickey, Benjamin, additional, Pillai, Anand, additional, Islam, Amirul, additional, Akbar, Zeeshan, additional, Naylor, Tom, additional, Khan, Umair, additional, Jowett, Charlie, additional, Mahmoud, Mohamed, additional, Cryer, Gunay, additional, and Place, Stuart, additional

Published
2022
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17. Unilateral Do-Not-Attempt-Resuscitation Orders: How Did We Get Here and Where Are We Going?

Author

Marks, Adam and Dixon, Joseph D.

Subjects
*TERMINAL care, *COVID-19 pandemic, *CARDIOPULMONARY resuscitation, *TERMINALLY ill, *CARDIAC arrest
Abstract

1. Utilizing a case-based approach, participants will self-report an understanding of the historical context of cardiopulmonary resuscitation, do-not-attempt-resuscitation (DNAR) orders, and unilateral do-not-attempt-resuscitation (UDNAR) orders. 2. Utilizing a case-based approach, participants will self report a knowledge of the ethical principles involved with UDNAR orders as well as concerns for unequal utilization of UDNAR orders for underserved populations. The principle of non-maleficence calls upon providers to not offer treatments we believe to be futile or non-beneficial. In recent years, this concept has led to the rise of so-called Unilateral Do-Not-Attempt-Resuscitation (UDNAR) orders. However, emerging evidence suggests that UDNAR orders may be disproportionately affecting underserved communities and may drive distrust between these communities and medical organizations. In serious illness communication, discussions around code status are common and typically occur in the context of end of life care. Traditionally, an individual's default code status has been understood to be "Full Code" and that cardiopulmonary resuscitation could only be withheld at the explicit request of a patient or their surrogate decision maker. However, providing full code measures for a patient dying of an irreversible process can cause a great deal of moral distress to clinicians. In the last 10-15 years the idea of a unilateral do-not-attempt resuscitation (UDNAR) order has gained increasing acceptance, recognizing that clinicians can identify when the aggressive treatment of a cardiopulmonary arrest provides little to no benefit to the terminally ill. More recently, however, controversies about when and how to invoke UNDAR orders have arisen. During the COVID pandemic, concerns were raised about inappropriate blanket DNAR orders for patient's severely ill with COVID, and recent studies have suggested that vulnerable populations may be inordinately subject to UDNAR orders in the hospital. In this case-based discussion, we will review the historical context of both cardiopulmonary resuscitation and do-not-attempt resuscitation (DNAR) orders; discuss the rise of UDNAR orders; outline the ethical argument for and against UDNAR orders; and explore recent work involving disparities in its application to patients at the end of life. Ethical / Legal Aspects of Care; Diversity, Equity, Inclusion, Belonging, Justice [ABSTRACT FROM AUTHOR]

Published
2024
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19. Safety evaluation of a strategy to restart elective orthopaedic surgery during the de-escalation phase of the COVID-19 pandemic

Author

Zahra, Wajiha, primary, Dixon, Joseph W., additional, Mirtorabi, Negin, additional, Rolton, Daniel J., additional, Tayton, Edward R., additional, Hale, Peter C., additional, Fisher, Warren J., additional, Barnes, Richard J., additional, Tunstill, Simon A., additional, Iyer, Shabnam, additional, and Pollard, Tom C. B., additional

Published
2020
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22. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice

Author

Nikonorova, Inna A., primary, Al-Baghdadi, Rana J.T., additional, Mirek, Emily T., additional, Wang, Yongping, additional, Goudie, Michael P., additional, Wetstein, Berish B., additional, Dixon, Joseph L., additional, Hine, Christopher, additional, Mitchell, James R., additional, Adams, Christopher M., additional, Wek, Ronald C., additional, and Anthony, Tracy G., additional

Published
2017
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24. Design, Synthesis and Applications of Lanthanide Metal-Organic Frameworks based on 1,2,4,5-benzenetetracarboxylic acid

Author

Dixon, Joseph William (author), De Lill, Daniel T. (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry, Dixon, Joseph William (author), De Lill, Daniel T. (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, and Department of Chemistry and Biochemistry

Abstract

Summary: The organic linker 1,2,4,5-benzenetetracarboxylic acid (BTC) has been widely used in the construction of lanthanide metal-organic frameworks (MOFs) due the high symmetry and versatile nature of its structure. Under identical hydrothermal reaction conditions, it was discovered that lanthanide BTC MOFs will form one of four unique structures based on its location in the series (La-Sm, Eu-Tb, Dy-Tm, Yb-Lu). This is uncommon in LOF materials, as in many cases the same compound can be produced for all of the lanthanides or two different structures may be observed for the first and second half of the series. Descriptions and comparisons of these structures as discussed herein, noticeably the decrease in coordination number and the lanthanide-oxygen bond lengths as the lanthanide atomic number increases. This thesis also attempts to use these compounds to catalyze a model mixed-aldol reaction. Two closely related BTC compounds from yttrium and uranium are also presented. The structure of the yttrium BTC MOFs was identical to that of the Eu, Gd and Tb compounds., 2015, Includes bibliography., Degree granted: Thesis (M.S.)--Florida Atlantic University, 2015., Collection: FAU Electronic Theses and Dissertations Collection

Published
2015

25. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment

Author

Wilson, Gabriel J., primary, Lennox, Brittany A., additional, She, Pengxiang, additional, Mirek, Emily T., additional, Al Baghdadi, Rana J. T., additional, Fusakio, Michael E., additional, Dixon, Joseph L., additional, Henderson, Gregory C., additional, Wek, Ronald C., additional, and Anthony, Tracy G., additional

Published
2015
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27. Oncogenic signaling in the adult Drosophila prostate-like accessory gland leads to activation of a conserved pro-tumorigenic program, in the absence of proliferation.

Author

Church SJ, Pulianmackal AJ, Dixon JA, Loftus LV, Amend SR, Pienta K, Cackowski FC, and Buttitta LA

Abstract

Drosophila models for tumorigenesis and metastasis have revealed conserved mechanisms of signaling that are also involved in mammalian cancer. Many of these models use the proliferating tissues of the larval stages of Drosophila development, when tissues are highly mitotically active, or stem cells are abundant. Fewer Drosophila tumorigenesis models use adult animals to initiate tumor formation when many tissues are largely terminally differentiated and postmitotic. The Drosophila accessory glands are prostate-like tissues and a model for some aspects of prostate tumorigenesis using this tissue has been explored. In this model, oncogenic signaling was induced during the proliferative stage of accessory gland development, raising the question of how oncogenic activity would impact the terminally differentiated and postmitotic adult tissue. Here, we show that oncogenic signaling in the adult Drosophila accessory gland leads to activation of a conserved pro-tumorigenic program, similar to that observed in mitotic larval tissues, but in the absence of proliferation. Oncogenic signaling in the adult postmitotic gland leads to tissue hyperplasia with nuclear anaplasia and aneuploidy through endoreduplication, which increases polyploidy and occasionally results in non-mitotic neoplastic-like extrusions. We compare gene expression changes in our Drosophila model with that of endocycling prostate cancer cells induced by chemotherapy, which potentially mediate tumor recurrence after treatment. Similar signaling pathways are activated in the Drosophila gland and endocycling cancer cells, suggesting the adult accessory glands provide a useful model for aspects of prostate cancer progression that do not involve cellular proliferation., Competing Interests: Conflicts of Interest: Kenneth Pienta discloses that he is a consultant to Cue Biopharma Inc., an equity holder in PEEL therapeutics, an equity holder in Keystone Biopharma Inc, and an equity holder in Kreftect, Inc. Sarah Amend discloses that she is an equity holder in Keystone Biopharma Inc.

Published
2024
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28. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.

Author

Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon JL, Henderson GC, Wek RC, and Anthony TG

Subjects
Adipose Tissue, White drug effects, Adipose Tissue, White metabolism, Adipose Tissue, White pathology, Animals, Antineoplastic Agents administration & dosage, Asparaginase administration & dosage, Biomarkers blood, Biomarkers metabolism, Chemical and Drug Induced Liver Injury pathology, Escherichia coli Proteins administration & dosage, Escherichia coli Proteins adverse effects, Female, Fibroblast Growth Factors blood, Gene Expression Regulation drug effects, Homeostasis drug effects, Injections, Intraperitoneal, Lipid Peroxidation drug effects, Liver metabolism, Liver pathology, Male, Mice, Inbred C57BL, Mice, Knockout, Protein Serine-Threonine Kinases genetics, RNA, Messenger metabolism, Antineoplastic Agents adverse effects, Asparaginase adverse effects, Chemical and Drug Induced Liver Injury metabolism, Fibroblast Growth Factors agonists, Liver drug effects, Protein Serine-Threonine Kinases metabolism, Triglycerides metabolism
Abstract

The antileukemic agent asparaginase triggers the amino acid response (AAR) in the liver by activating the eukaryotic initiation factor 2 (eIF2) kinase general control nonderepressible 2 (GCN2). To explore the mechanism by which AAR induction is necessary to mitigate hepatic lipid accumulation and prevent liver dysfunction during continued asparaginase treatment, wild-type and Gcn2 null mice were injected once daily with asparaginase or phosphate buffered saline for up to 14 days. Asparaginase induced mRNA expression of multiple AAR genes and greatly increased circulating concentrations of the metabolic hormone fibroblast growth factor 21 (FGF21) independent of food intake. Loss of Gcn2 precluded mRNA expression and circulating levels of FGF21 and blocked mRNA expression of multiple genes regulating lipid synthesis and metabolism including Fas, Ppara, Pparg, Acadm, and Scd1 in both liver and white adipose tissue. Furthermore, rates of triglyceride export and protein expression of apolipoproteinB-100 were significantly reduced in the livers of Gcn2 null mice treated with asparaginase, providing a mechanistic basis for the increase in hepatic lipid content. Loss of AAR-regulated antioxidant defenses in Gcn2 null livers was signified by reduced Gpx1 gene expression alongside increased lipid peroxidation. Substantial reductions in antithrombin III hepatic expression and activity in the blood of asparaginase-treated Gcn2 null mice indicated liver dysfunction. These results suggest that the ability of the liver to adapt to prolonged asparaginase treatment is influenced by GCN2-directed regulation of FGF21 and oxidative defenses, which, when lost, corresponds with maladaptive effects on lipid metabolism and hemostasis., (Copyright © 2015 the American Physiological Society.)

Published
2015
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