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Your search keyword '"Dong, Wen Fei"' showing total 401 results
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401 results on '"Dong, Wen Fei"'

19. Metal‐Doping Strategy for Carbon‐Based Sonosensitizer in Sonodynamic Therapy of Glioblastoma.

Author

Cheng, Mingming, Liu, Yan, You, Qiannan, Lei, Zhubing, Ji, Jiajian, Zhang, Fan, Dong, Wen‐Fei, and Li, Li

Subjects
TUMOR growth, GLIOBLASTOMA multiforme, WESTERN immunoblotting, BRAIN tumors, THERAPEUTICS
Abstract

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and known for its challenging prognosis. Sonodynamic therapy (SDT) is an innovative therapeutic approach that shows promise in tumor elimination by activating sonosensitizers with low‐intensity ultrasound. In this study, a novel sonosensitizer is synthesized using Cu‐doped carbon dots (Cu‐CDs) for the sonodynamic treatment of GBM. Doping with copper transforms the carbon dots into a p–n type semiconductor having a bandgap of 1.58 eV, a prolonged lifespan of 10.7 µs, and an improved electron‐ and hole‐separation efficiency. The sonodynamic effect is efficiency enhanced. Western blot analysis reveals that the Cu‐CDs induces a biological response leading to cell death, termed as cuproptosis. Specifically, Cu‐CDs upregulate dihydrosulfanyl transacetylase expression, thereby establishing a synergistic therapeutic effect against tumor cell death when combined with SDT. Furthermore, Cu‐CDs exhibit excellent permeability through the blood‐brain barrier and potent anti‐tumor activity. Importantly, the Cu‐CDs effectively impede the growth of glioblastoma tumors and prolong the survival of mice bearing these tumors. This study provides support for the application of carbon‐based nanomaterials as sonosensitizers in tumor therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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25. MXene quantum dot functionalized bimetallic MOFs as a label-free aptasensor for highly sensitive detection of exosomes.

Author

Su, Xue, You, Qiannan, Wang, Panyong, Li, Li, Ge, Mingfeng, Yang, Li, Dong, Wen-Fei, and Chang, Zhimin

Abstract

Exosomes have attracted increasing attention in the early diagnosis of tumors due to their participation in physiological and pathological processes. Herein, a novel label-free aptasensor based on the CuNi bimetallic metal–organic frameworks (MOFs) that was decorated with MXene quantum dots (MQDs) was fabricated for exosome sensing. The CuNi-MOFs functionalized with dual specific aptamers, CD63 and MUC1, served as an ideal nanocarrier and catalyst for efficient recognition and capture of target exosomes. Meanwhile, the MQDs with excellent electron transfer can promote the electrochemical catalytic performance of this designed aptasensor. It is noteworthy that the large specific surface area of 2D bimetallic CuNi-MOF nanosheets can offer plenty of exposed active sites and facilitate the connection of aptamers, thereby achieving the goal of specific capture and detection of exosomes. The as-prepared electrochemical aptasensor possesses a wide linear range of 1 × 101 to 1 × 106 particles μL−1 for exosome detection and a low detection limit of 5 particles μL−1 (S/N = 3). Besides, the as-prepared aptasensor exhibited satisfactory electrochemical stability for the detection of exosomes, which can provide new ideas for clinical detection and tumor diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Engineering a biomimetic system for hepatocyte-specific RNAi treatment of non-alcoholic fatty liver disease

Author

He, Xuan, primary, Chang, Zhimin, additional, Chen, Fangman, additional, Zhang, Wensheng, additional, Sun, Madi, additional, Shi, Tongfei, additional, Liu, Jie, additional, Chen, Peiyu, additional, Zhang, Kunbao, additional, Guan, Shan, additional, Zhao, Zhibin, additional, Li, Mingqiang, additional, Dong, Wen-fei, additional, Shao, Dan, additional, and Yang, Chao, additional

Published
2023
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32. An all-optical multidirectional mechano-sensor inspired by biologically mechano-sensitive hair sensilla.

Author

Li, Yuxiang, Guo, Zhihe, Zhao, Xuyang, Liu, Sheng, Chen, Zhenmin, Dong, Wen-Fei, Wang, Shixiang, Sun, Yun-Lu, and Wu, Xiang

Subjects
HAIR, ROBOTICS, BIOLOGICALLY inspired computing, RESONATORS
Abstract

Mechano-sensitive hair-like sensilla (MSHS) have an ingenious and compact three-dimensional structure and have evolved widely in living organisms to perceive multidirectional mechanical signals. Nearly all MSHS are iontronic or electronic, including their biomimetic counterparts. Here, an all-optical mechano-sensor mimicking MSHS is prototyped and integrated based on a thin-walled glass microbubble as a flexible whispering-gallery-mode resonator. The minimalist integrated device has a good directionality of 32.31 dB in the radial plane of the micro-hair and can detect multidirectional displacements and forces as small as 70 nm and 0.9 μN, respectively. The device can also detect displacements and forces in the axial direction of the micro-hair as small as 2.29 nm and 3.65 μN, respectively, and perceive different vibrations. This mechano-sensor works well as a real-time, directional mechano-sensory whisker in a quadruped cat-type robot, showing its potential for innovative mechano-transduction, artificial perception, and robotics applications. Hair-like sensilla are evolved widely in organisms that perceive mechanical signals. Here, the authors report an all-optical mechano-sensor that can detect the real-time, directional displacement and force at several nm and μN levels. [ABSTRACT FROM AUTHOR]

Published
2024
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