50 results on '"Douglas, Morgan"'
Search Results
2. Effects of nonnutritive sugar inclusion in laboratory diets and attracticidal spheres on survivorship and mobility of 2 Dipteran species, Rhagoletis pomonella (Diptera: Tephritidae) and Drosophila suzukii (Diptera: Drosophilidae)
- Author
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Nixon, Laura J, primary, Douglas, Morgan, additional, Ibrahim, Aya, additional, Jones, Sharon, additional, Piñero, Jaime C, additional, and Leskey, Tracy C, additional
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- 2024
- Full Text
- View/download PDF
3. Multi-omic evaluation of metabolic alterations in multiple sclerosis identifies shifts in aromatic amino acid metabolism
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Fitzgerald, Kathryn C., Smith, Matthew D., Kim, Sol, Sotirchos, Elias S., Kornberg, Michael D., Douglas, Morgan, Nourbakhsh, Bardia, Graves, Jennifer, Rattan, Ramandeep, Poisson, Laila, Cerghet, Mirela, Mowry, Ellen M., Waubant, Emmanuelle, Giri, Shailendra, Calabresi, Peter A., and Bhargava, Pavan
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- 2021
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4. Transparência e accountability de algoritmos governamentais: o caso do sistema eletrônico de votação brasileiro
- Author
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DOUGLAS MORGAN FULLIN SALDANHA and MARCELA BARBOSA DA SILVA
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Governo eletrônico ,Governança digital ,Urna eletrônica ,Boas práticas ,Princípios ,Business ,HF5001-6182 - Abstract
Resumo Nos últimos anos, uma série de movimentos de dados abertos tem surgido ao redor do mundo, assegurando aos cidadãos mais oportunidades para acessar informações, sendo a transparência um fator associado à confiança nas organizações públicas e no governo. A transparência em algoritmos traduz-se no conhecimento dos passos realizados e critérios adotados para a obtenção de determinado resultado. O objetivo deste estudo consiste em identificar as características de transparência e accountability do sistema eletrônico de votação brasileiro. Por meio do estudo de caso, foram confrontadas recomendações e boas práticas de transparência - que propiciam controle e fiscalização por parte da sociedade em algoritmos - com as particularidades do sistema de votação eletrônico brasileiro. Este estudo avança na discussão da influência das novas tecnologias na democracia, situando o sistema eletrônico de votação brasileiro nos limites da transparência e accountability de algoritmos e do governo em geral.
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- 2020
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5. Transparency and accountability of government algorithms: the case of the Brazilian electronic voting system/Transparencia e accountability de algoritmos governamentais: o caso do sistema eletronico de votacao brasileiro/Transparencia y accountability de algoritmos gubernamentales: el caso del sistema electoral electronic brasileno
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Saldanha, Douglas Morgan Fullin and Da Silva, Marcela Barbosa
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- 2020
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6. Cryopreservation of Anopheles stephensi (MOSQUITO) EGGS: EFFECTS ON GENOTYPIC AND PHENOTYPIC CHARACTERISTICS
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Douglas, Morgan, primary, Inbar, Ehud, additional, Sharakov, Igor, additional, El-Sayed, Najib M., additional, Belew, Ashton T., additional, Overby, James, additional, Matheny, Steve, additional, Addisu, Fantahun, additional, Abebe, Yonas, additional, Koutzoumis, Dimitri, additional, Springer, Kerri, additional, Eappen, Abraham, additional, Billingsley, Peter F., additional, and James, Eric R., additional
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- 2023
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7. Effects of nonnutritive sugar inclusion in laboratory diets and attracticidal spheres on survivorship and mobility of 2 Dipteran species, Rhagoletis pomonella(Diptera: Tephritidae) and Drosophila suzukii(Diptera: Drosophilidae)
- Author
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Nixon, Laura J, Douglas, Morgan, Ibrahim, Aya, Jones, Sharon, Piñero, Jaime C, and Leskey, Tracy C
- Abstract
Native apple maggot fly, Rhagoletis pomonella, and invasive spotted-wing drosophila, Drosophila suzukii, are key pests of apple and small fruit, respectively, in the United States. Both species are typically managed with standard insecticide applications. However, interest in alternative strategies that result in insecticide reductions has led to evaluations of nonnutritive sugars as toxicants for Drosophilaspecies and development of attracticidal spheres for both species. Here, we evaluated the survivorship of R. pomonellaand D. suzukiiwhen provided with standard diets that substituted saccharin, sucralose, aspartame, erythritol, dextrose, or mannitol for the sucrose component and compared them with standard diets and water-only controls for up to 15 days. Presence of erythritol and mannitol significantly decreased survivorship of R. pomonellaand erythritol significantly decreased the survivorship of D. suzukii.However, mobility trials following a 2 h exposure to aqueous solutions of each sugar treatment resulted in no strong impact on either species. Survivorship after 30 min exposure to erythritol or mannitol alone, or in combination with varying concentrations of sucrose (serving as a phagostimulant) at 30 min and 24 h were evaluated for both species. Only D. suzukiisurvivorship was affected with decreased survivorship on erythritol:sucrose solutions of 20:0% and 15:5% for 24 h. Based on all results, erythritol appeared most promising, and was integrated into attracticidal spheres as a toxicant but even at the highest concentration, survivorship remained unaffected for either species, thus making this nonnutritive sugar impractical and ineffective as a toxicant substitute in attracticidal spheres.
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- 2024
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8. Temperature profiles of hot gas in early-type galaxies
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Dong-Woo Kim, Liam Traynor, Alessandro Paggi, Ewan O'Sullivan, Craig Anderson, Douglas Burke, Raffaele D'Abrusco, Giuseppina Fabbiano, Antonella Fruscione, Jennifer Lauer, Michael McCollough, Douglas Morgan, Amy Mossman, Saeqa Vrtilek, and Ginevra Trinchieri
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- 2019
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9. Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes
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Ehrhardt, Henrik, primary, Lambe, Jeffrey, additional, Moussa, Hussein, additional, Vasileiou, Eleni S., additional, Kalaitzidis, Grigorios, additional, Murphy, Olwen C., additional, Filippatou, Angeliki G., additional, Pellegrini, Nicole, additional, Douglas, Morgan, additional, Davis, Simidele, additional, Nagy, Natalia, additional, Quiroga, Agustina, additional, Hu, Chen, additional, Zambriczki Lee, Alexandra, additional, Duval, Anna, additional, Fitzgerald, Kathryn C., additional, Prince, Jerry L., additional, Calabresi, Peter A., additional, Sotirchos, Elias S., additional, Bermel, Robert, additional, and Saidha, Shiv, additional
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- 2023
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10. Transparency and accountability in digital public services: Learning from the Brazilian cases.
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Douglas Morgan Fullin Saldanha, Cleidson Nogueira Dias, and Siegrid Guillaumon
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- 2022
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11. An XMM-Newton Early-type Galaxy Atlas
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Nazma Islam, Dong-Woo Kim, Kenneth Lin, Ewan O'Sullivan, Craig Anderson, Giuseppina Fabbiano, Jennifer Lauer, Douglas Morgan, Amy Mossman, and Alessandro Paggi
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Astrophysics ,Astronomy - Abstract
The distribution of hot interstellar medium in early-type galaxies(ETGs)bears the imprint of the various astrophysical processes it underwent during its evolution. The X-ray observations of these galaxies have identified various structural features related to active galactic nucleus(AGN)and stellar feedback and environmental effects such as merging and sloshing. In our XMM-Newton Galaxy Atlas(NGA)project, we analyze archival observations of 38 ETGs, utilizing the high sensitivity and large field of view of XMM-Newton to construct spatially resolved 2D spectral maps of the hot gas halos. To illustrate our NGA data products in conjunction with the Chandra Galaxy Atlas, we describe two distinct galaxies, NGC 4636 and NGC 1550, in detail. We discuss the revolutionary history with a particular focus on the asymmetric distribution of metal-enriched, low-entropy gas caused by sloshing and AGN-driven uplift. We will release the NGA data products to a dedicated website, from where users can download them to perform further analyses.
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- 2021
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12. HIV related hypochlorhydria does not appear to respond to anti-retroviral therapy in Zambian adults: a case control study
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Violet Kayamba, Aaron Shibemba, Kanekwa Zyambo, Douglas Corbett Heimburger, Douglas Morgan, and Paul Kelly
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hiv ,intestinal metaplasia ,hypochlorhydria ,gastric atrophy ,pepsinogen ,Medicine - Abstract
INTRODUCTION: Human Immunodeficiency Virus (HIV) infection is associated with hypochlorhydria but the mechanism is unknown. The objective of this study was to determine effects of anti-retroviral therapy (ART) on gastric physiology as measured by validated markers. METHODS: we studied HIV infected individuals who were either ART-naïve or on treatment with undetectable viral loads. We measured H.pylori IgG antibodies, pepsinogen (PG) 1 and 2 levels and fasting gastrin-17 using Biohit GastroPanel. Gastric antral biopsies and juice were obtained for histology and pH respectively. Also included were historical data from HIV negative participants (n = 72) in a previous study, for reference. RESULTS: we enrolled 84 HIV positive individuals with a median age 42 years (IQR 37-40 years). 55(66%) were female, 32(38%) were ART naïve, and 52(62%) were on ART. Hypochlorhydria (pH4) was present in 48(57%) of the HIV positive and 18(25%) of the HIV negative individuals (OR 4: 95% CI 1.9-8.5, p=0.001) with no significant effect of ART (OR 0.9: 95% CI 0.3-2.3, P = 0.82). Hypochlorhydria was not associated with the serological detection of corpus atrophy using low PG 1:2 ratio (OR 2.1: 95% CI 0.5-10.2, P = 0.37) or GastroPanel algorithm, (OR 0.7: 95% CI 0.01-60.1, P = 1.0). ART reduced the frequency of low PG 1:2 ratio (P = 0.001), but not the histological detection in the antrum of atrophy or non-atrophic gastritis. CONCLUSION: ART use is associated with reduced serological evidence of corpus atrophy but has no effect on fasting pH, supporting earlier data that suggest that the mechanism of HIV-associated hypochlorhydria is multifactorial.
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- 2018
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13. Effects of Myopia on Rates of Change in Optical Coherence Tomography Measured Retinal Layer Thicknesses in People with Multiple Sclerosis and Healthy Controls
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Kalaitzidis, Grigorios, primary, Pellegrini, Nicole, additional, Nagy, Natalia, additional, Vasileiou, Eleni, additional, Ehrhardt, Henrik, additional, Reppen, Abbey, additional, Murphy, Olwen C., additional, Moussa, Hussein, additional, Filippatou, Angeliki, additional, Lambe, Jeffrey, additional, DuVal, Anna, additional, Fioravante, Nicholas, additional, Kwakyi, Ohemaa, additional, Nguyen, James, additional, Davis, Simidele, additional, Douglas, Morgan, additional, Ramirez, Alexandra, additional, Ecoff, Katie, additional, Valenzuela, Alyssandra, additional, Reyes-Mantilla, Maria, additional, Hu, Chen, additional, Fitzgerald, Kathryn C., additional, Sotirchos, Elias S., additional, Saidha, Shiv, additional, and Calabresi, Peter A., additional
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- 2022
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14. S369 Dysphagia From an Ischemic Colonic Segment in a Patient With Colon Interposition
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Yassmin Hegazy, Usman Barlass, Douglas Morgan, Dane Johnson, Pooja Bhavsar, and Kondal R. Kyanam Kabir Baig
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Hepatology ,Gastroenterology - Published
- 2022
15. S3363 A Case of Progressive Refractory Diarrhea due to Zollinger-Ellison Syndrome
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Yassmin Hegazy, Dane Johnson, Jim McPhail, and Douglas Morgan
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Hepatology ,Gastroenterology - Published
- 2022
16. S942 Initial Descriptive Epidemiology of Inflammatory Bowel Disease in Northern Central America
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Eleazar E. Montalvan-Sanchez, Katherine Falloon, Dalton A. Norwood, Luis Alfredo Najera Donis, Renato Beas, Aida Rodriguez Murillo, Kathya Jimenez, Roberto Giron, Do Han Kim, Rawan Aljaras, Jonathan Montrose, Deborah Proctor, and Douglas Morgan
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Hepatology ,Gastroenterology - Published
- 2022
17. S1612 High Seroprevalence of Helicobacter pylori and CagA/VacA Virulence Factors in Northern Central America
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Dalton A. Norwood, Do Han Kim, Eleazar E. Montalvan-Sanchez, Christian S. Alvarez, Alvaro Rivera-Andrade, Ricardo L. Dominguez, Katherine A. McGlynn, Manuel Ramirez-Zea, Douglas Morgan, and Juan E. Corral
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Hepatology ,Gastroenterology - Published
- 2022
18. Transparência e accountability de algoritmos governamentais: o caso do sistema eletrônico de votação brasileiro
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Marcela Barbosa da Silva and Douglas Morgan Fullin Saldanha
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Governança digital ,Electronic ballot ,HF5001-6182 ,05 social sciences ,Buenas prácticas ,Boas práticas ,Digital governance ,Gobierno electrónico ,Gobernanza digital ,Principios ,Electronic governing ,0506 political science ,Governo eletrônico ,Urna eletrônica ,0502 economics and business ,Princípios ,050602 political science & public administration ,General Earth and Planetary Sciences ,Urna electrónica ,Good practices ,Business ,Principles ,050203 business & management ,General Environmental Science - Abstract
Resumo Nos últimos anos, uma série de movimentos de dados abertos tem surgido ao redor do mundo, assegurando aos cidadãos mais oportunidades para acessar informações, sendo a transparência um fator associado à confiança nas organizações públicas e no governo. A transparência em algoritmos traduz-se no conhecimento dos passos realizados e critérios adotados para a obtenção de determinado resultado. O objetivo deste estudo consiste em identificar as características de transparência e accountability do sistema eletrônico de votação brasileiro. Por meio do estudo de caso, foram confrontadas recomendações e boas práticas de transparência - que propiciam controle e fiscalização por parte da sociedade em algoritmos - com as particularidades do sistema de votação eletrônico brasileiro. Este estudo avança na discussão da influência das novas tecnologias na democracia, situando o sistema eletrônico de votação brasileiro nos limites da transparência e accountability de algoritmos e do governo em geral. Resumen En los últimos años, han surgido varios movimientos de datos abiertos en todo el mundo, que garantizan a los ciudadanos más oportunidades para acceder a la información, y la transparencia es un factor asociado con la confianza en las organizaciones públicas y el gobierno. La transparencia en los algoritmos se traduce en el conocimiento de los pasos realizados y los criterios adoptados para obtener un resultado determinado. El objetivo de este estudio es identificar las características de transparencia y responsabilidad del sistema electoral electrónico brasileño. A través del estudio de caso, las recomendaciones y las buenas prácticas de transparencia se confrontaron con las particularidades del sistema electoral electrónico brasileño, que proporciona control y supervisión por parte de la sociedad en algoritmos. Este estudio avanza en la discusión sobre la influencia de las nuevas tecnologías en la democracia, colocando el sistema electoral electrónico brasileño dentro de los límites de transparencia y responsabilidad de los algoritmos y del gobierno en general. Abstract In recent years a number of open data movements have emerged around the world, ensuring citizens more opportunities to access information, transparency being a factor associated with trust in public organizations and government. The transparency in algorithms translates into the knowledge of the steps performed and the criteria adopted to obtain a certain result. The objective of this study is to identify the characteristics of transparency and accountability of the Brazilian electronic voting system. Through the case study, recommendations and good practices of transparency in algorithms were examined with the particularities of the Brazilian electronic voting system, which provides control and oversight to society. This study advances the discussion on the influence of new technologies on democracy, placing the Brazilian electronic voting system within the limits of transparency and accountability of algorithms and the government in general.
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- 2020
19. Transparency and accountability of government algorithms: the case of the Brazilian electronic voting system
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Marcela Barbosa da Silva and Douglas Morgan Fullin Saldanha
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Government ,business.industry ,Electronic voting ,05 social sciences ,Accounting ,Transparency (behavior) ,0506 political science ,Political science ,0502 economics and business ,Accountability ,050602 political science & public administration ,General Earth and Planetary Sciences ,business ,050203 business & management ,General Environmental Science - Abstract
Resumo Nos últimos anos, uma série de movimentos de dados abertos tem surgido ao redor do mundo, assegurando aos cidadãos mais oportunidades para acessar informações, sendo a transparência um fator associado à confiança nas organizações públicas e no governo. A transparência em algoritmos traduz-se no conhecimento dos passos realizados e critérios adotados para a obtenção de determinado resultado. O objetivo deste estudo consiste em identificar as características de transparência e accountability do sistema eletrônico de votação brasileiro. Por meio do estudo de caso, foram confrontadas recomendações e boas práticas de transparência - que propiciam controle e fiscalização por parte da sociedade em algoritmos - com as particularidades do sistema de votação eletrônico brasileiro. Este estudo avança na discussão da influência das novas tecnologias na democracia, situando o sistema eletrônico de votação brasileiro nos limites da transparência e accountability de algoritmos e do governo em geral.
- Published
- 2020
20. Effects of Myopia on Rates of Change in Optical Coherence Tomography Measured Retinal Layer Thicknesses in People with Multiple Sclerosis and Healthy Controls.
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Kalaitzidis, Grigorios, Pellegrini, Nicole, Nagy, Natalia, Vasileiou, Eleni, Ehrhardt, Henrik, Reppen, Abbey, Murphy, Olwen C., Moussa, Hussein, Filippatou, Angeliki, Lambe, Jeffrey, DuVal, Anna, Fioravante, Nicholas, Kwakyi, Ohemaa, Nguyen, James, Davis, Simidele, Douglas, Morgan, Ramirez, Alexandra, Ecoff, Katie, Valenzuela, Alyssandra, and Reyes-Mantilla, Maria
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OPTICAL coherence tomography ,MYOPIA ,MULTIPLE sclerosis ,REFRACTIVE errors ,RETINAL artery ,NERVE fibers ,CHOROID - Abstract
To quantify the associations of myopia with longitudinal changes in retinal layer thicknesses in people with multiple sclerosis (PwMS) and healthy controls (HC). A cohort of PwMS and HC with recorded refractive error (RE) prospectively scanned on Cirrus HD-OCT at the Johns Hopkins MS Center was assessed for inclusion. Exclusion criteria included OCT follow-up < 6 months, ocular comorbidities, incidental OCT pathologies, and inadequate scan quality. Eyes were classified as having high myopia (HM) (RE≤ −6 diopters), low myopia (LM) (RE> −6 and ≤ −3 diopters), or no myopia (NM) (RE> −3 and ≤ +2.75). Linear mixed-effects regression models were used in analyses. A total of 213 PwMS (eyes: 67 HM, 98 LM, 207 NM) and 80 HC (eyes: 26 HM, 37 LM, 93 NM) were included. Baseline average ganglion cell/inner plexiform (GCIPL) and peri-papillary retinal nerve fiber layer (pRNFL) thicknesses were lower in MS HM compared with MS NM (diff: −3.2 µm, 95% CI: −5.5 to −0.8, p = 0.008 and −5.3 µm, 95% CI: −9.0 to −1.7, p = 0.004, respectively), and similarly in HC HM, as compared with HC NM. Baseline superior, inferior, and nasal pRNFL thicknesses were lower in HM compared with NM, while temporal pRNFL thickness was higher, both in MS and HC (MS: 7.1 µm, 95% CI: 2.7–11.6, p = 0.002; HC: 4.7 µm, 95% CI: −0.3 to 9.7, p = 0.07). No longitudinal differences in rates of GCIPL change were noted between HM and LM vs. NM, either in MS or HC. Cross-sectional differences in average GCIPL and pRNFL thicknesses are commonly seen in people with HM as compared to reference normative values from people with NM and can lead to false attribution of pathology if RE is not taken into account. However, our study suggests that longitudinal changes in average GCIPL thickness in PwMS with myopia are similar in magnitude to PwMS with NM, and therefore are appropriate for monitoring disease-related pathology. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Abstract A016: Successful design and execution of two gastric cancer chemoprevention trials in Central America and Puerto Rico
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Eleazar Montalvan-Sanchez, Maria Gonzalez-Pons, Dalton Norwood, Ricardo Dominguez, Keith Wilson, Marcia Cruz-Correa, and Douglas Morgan
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Cancer Research ,Oncology - Abstract
Gastric adenocarcinoma (GAC) is the third leading global cause of cancer mortality and leading infection-associated cancer. The high incidence regions are Latin America, East Asia, and Eastern Europe. In the U.S., GAC represents a major cancer disparity, double the incidence rates in all non-white populations, the opposite of Barrett’s Esophagus and EAC. Immigrants from high incidence regions maintain the risk profile of their nations of origin. In a paradigm shift, recent guidelines now recommend surveillance endoscopy (eg, 3 years) for patients with high-risk gastric premalignant conditions (GPMCs). Clinical trials of chemoprevention agents for patients with GPMCs are lacking. We conducted two independent, NCI DCP funded, phase II placebo-controlled chemoprevention trials in patients with GPMCs (intestinal metaplasia, atrophic gastritis). The oral agents were curcumin and eflornithine (DFMO). A highly bioavailable preparation of curcumin was used. The RCTs were conducted in Puerto Rico and rural Honduras, with important characteristics: (1) representative of Caribbean and Mesoamerican populations and linked to large U.S. immigrant populations; (2) high prevalence of H. pylori infection and GPMCs; (3) absence of turmeric and curcuminoids in the local diets; (4) proven bidirectional collaboration with academic institutions in the U.S. In the curcumin trial (NCT02782949) H. pylori negative patients were randomized to study drug or placebo for 6 months. In the eflornithine study (NCT02794428), H. pylori positive and negative subjects were randomized to study drug or placebo for 18 months, with endoscopy at baseline, and 6. 18, and 24 months. The primary outcomes were based upon changes in histologic parameters at 6 months. Principal study challenges included: (1) International and bilingual regulatory environment; (2) Strengthening of the research infrastructure, particularly in Central America; (3) Participant recruitment, eg, in the curcumin RCT in Honduras wherein only 10-15% are H. pylori negative; (4) The Covid-19 pandemic; (5) Natural disasters (3 hurricanes). In Conclusion: Eflornithine and curcumin RCTs have been successfully completed, despite important challenges in implementation and execution. No losses to follow-up were encountered related to the pandemic or natural disasters. The south-south partnership may provide a model for chemoprevention and translational studies in Latino populations with prevalent cancers such as GAC. Citation Format: Eleazar Montalvan-Sanchez, Maria Gonzalez-Pons, Dalton Norwood, Ricardo Dominguez, Keith Wilson, Marcia Cruz-Correa, Douglas Morgan. Successful design and execution of two gastric cancer chemoprevention trials in Central America and Puerto Rico [abstract]. In: Proceedings of the Second Biennial NCI Meeting: Translational Advances in Cancer Prevention Agent Development (TACPAD); 2022 Sep 7-9. Philadelphia (PA): AACR; Can Prev Res 2022;15(12 Suppl_2): Abstract nr A016.
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- 2022
22. Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy
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Gadani, Sachin P., primary, Reyes-Mantilla, Maria, additional, Jank, Larissa, additional, Harris, Samantha, additional, Douglas, Morgan, additional, Smith, Matthew D., additional, Calabresi, Peter A., additional, Mowry, Ellen M., additional, Fitzgerald, Kathryn C., additional, and Bhargava, Pavan, additional
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- 2021
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23. Risk Factors for Infection and Health Impacts of the Coronavirus Disease 2019 (COVID-19) Pandemic in People With Autoimmune Diseases
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Fitzgerald, Kathryn C, primary, Mecoli, Christopher A, additional, Douglas, Morgan, additional, Harris, Samantha, additional, Aravidis, Berna, additional, Albayda, Jemima, additional, Sotirchos, Elias S, additional, Hoke, Ahmet, additional, Orbai, Ana-Maria, additional, Petri, Michelle, additional, Christopher-Stine, Lisa, additional, Baer, Alan N, additional, Paik, Julie J, additional, Adler, Brittany L, additional, Tiniakou, Eleni, additional, Timlin, Homa, additional, Bhargava, Pavan, additional, Newsome, Scott D, additional, Venkatesan, Arun, additional, Chaudhry, Vinay, additional, Lloyd, Thomas E, additional, Pardo, Carlos A, additional, Stern, Barney J, additional, Lazarev, Mark, additional, Truta, Brindusa, additional, Saidha, Shiv, additional, Chen, Edward S, additional, Sharp, Michelle, additional, Gilotra, Nisha, additional, Kasper, Edward K, additional, Gelber, Allan C, additional, Bingham, Clifton O, additional, Shah, Ami A, additional, and Mowry, Ellen M, additional
- Published
- 2021
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24. RISK FACTORS FOR INFECTION AND HEALTH IMPACTS OF THE COVID-19 PANDEMIC IN PEOPLE WITH AUTOIMMUNE DISEASES
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Fitzgerald, Kathryn C., primary, Mecoli, Christopher A., additional, Douglas, Morgan, additional, Harris, Samantha, additional, Aravidis, Berna, additional, Albayda, Jemima, additional, Sotirchos, Elias S., additional, Hoke, Ahmet, additional, Orbai, Ana-Maria, additional, Petri, Michelle, additional, Christopher-Stine, Lisa, additional, Baer, Alan N., additional, Paik, Julie J., additional, Adler, Brittany L., additional, Tiniakou, Eleni, additional, Timlin, Homa, additional, Bhargava, Pavan, additional, Newsome, Scott D., additional, Venkatesan, Arun, additional, Chaudhry, Vinay, additional, Lloyd, Thomas E., additional, Pardo, Carlos A., additional, Stern, Barney J., additional, Lazarev, Mark, additional, Truta, Brindusa, additional, Saidha, Shiv, additional, Chen, Edward S., additional, Sharp, Michelle, additional, Gilotra, Nisha, additional, Kasper, Edward K., additional, Gelber, Allan C., additional, Bingham, Clifton O., additional, Shah, Ami A., additional, and Mowry, Ellen M., additional
- Published
- 2021
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25. Multi-omic Evaluation of Metabolic Alterations in Multiple Sclerosis Identifies Shifts in Aromatic Amino Acid Metabolism
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Fitzgerald, Kathryn C., primary, Smith, Matthew D., additional, Sotirchos, Elias S., additional, Kornberg, Michael D., additional, Douglas, Morgan, additional, Nourbakhsh, Bardia, additional, Graves, Jennifer, additional, Rattan, Ramandeep, additional, Poisson, Laila, additional, Cerghet, Mirela, additional, Mowry, Ellen M., additional, Waubant, Emmanuelle, additional, Giri, Shailendra, additional, Calabresi, Peter A., additional, and Bhargava, Pavan, additional
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- 2021
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26. Measurement of Mentoring Program Outcomes
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Mark Douglas Morgan
- Subjects
ComputingMilieux_GENERAL ,ComputingMilieux_THECOMPUTINGPROFESSION ,Psychology - Abstract
The purpose of this research study was to investigate how mentoring is measured and assessed in the workplace by reviewing and synthesizing qualitative, quantitative and mixed methods studies that appear in the professional literature. Mentoring programs are common practice in the workplace. The one-on-one nature of a formal mentoring program creates outcomes that benefit the protégé throughout their career in three ways: onboarding, retention at an organization, and career advancement. However, mentoring programs are expensive, both in terms of direct monetary cost and the time it takes to complete the tasks associated with mentoring, making measurement of outcomes critical for organizations. The primary question of this study was: how do organizations assess the outcomes of mentoring programs? There were three sub-questions that will provide the details to the primary question: what are the assessed outcomes of mentoring programs; what quantitative measures and scales do organizations use to assess mentoring programs; how do organizations qualitatively assess mentoring programs? The study was conducted using a systematic multiple studies review (MSR) to answer the research questions. The researcher followed the seven steps of the MSR process as outlined by Petticrew and Roberts (2006). The researcher used the systematic process to narrow an initial search result of 4,795 articles down to the final twenty which included qualitative, quantitative and mixed methods research written between 2012 and 2018 about outcomes of participants in formal mentor programs in the business environment. The key results found during this study were that organizations have measured mentor program outcomes by focusing on seven key themes: career resilience, career success, employee engagement, mutual development, personal learning, protégé satisfaction and professional exposure. Of those themes, the most measured outcome themes by quantitative methods were career success, professional exposure and personal learning. Qualitative assessment in the studies used in this MSR focused on career success and mutual development. Fifteen of the seventeen qualitative studies in this MSR measured outcomes of mentoring by survey of the protégé and/or mentor. The remaining two qualitative studies measured outcomes by extant data. Both qualitative studies assessed mentoring outcomes via interview. The mixed methods study used both interview and survey. The desired benefits and the expense of formal mentoring programs show the importance of evaluating the outcomes. This MSR shows that mentoring can be evaluated successfully using quantitative methods, especially by survey, and qualitatively, especially by interview. When determining what to evaluate, an organization needs to consider which outcomes to focus on then align their study to those specific themes, as the studies in this MSR have modeled. Rather than focusing on only the quality of the mentoring experience or satisfaction with mentoring, evaluation should focus tying the mentoring experience to outcomes like job satisfaction, level of employee engagement, and adjustment to new job environments to show the organizational impact of a formal mentor program.
- Published
- 2020
27. Transparência e accountability em serviços públicos digitais
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Saldanha, Douglas Morgan Fullin and Dias, Cleidson Nogueira
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Serviços públicos eletrônicos ,Accountability ,Transparência na administração pública - Abstract
Dissertação (mestrado)—Universidade de Brasília, Faculdade de Economia, Administração, Contabilidade e Gestão de Políticas Públicas, Programa de Pós-Graduação em Administração, Mestrado Profissional em Administração Pública, 2020. O avanço tecnológico vem introduzindo um novo tipo de racionalização no setor público pelo uso das modernas tecnologias de informação e comunicação (TICs), acarretando mudanças em políticas públicas, processos e funções. Cada vez mais os serviços públicos têm sido disponibilizados no meio digital, aumentando a dependência do cidadão em relação aos seus resultados. Ocorre que os resultados e decisões oriundos de sistemas ou processos automatizados são pouco transparentes e dificultam eventual contestação em caso de resultados indevidos. A transparência e accountability de sistemas e algoritmos tem por finalidade proteger o usuário contra resultados indesejáveis ou prejudiciais e assegurar a aplicação das leis ao meio digital. Assim, o objetivo do estudo é verificar a transparência e accountability proporcionada ao cidadão em serviços públicos digitais (eserviços) oferecidos pela Administração Pública Federal brasileira. Adotando uma abordagem qualitativa, a pesquisa avaliou três serviços públicos digitais brasileiros (ComprasNet, Sisu e Naturalizar-se) a fim de avaliar o tratamento que tais serviços vêm dispensando à transparência e accountability. As avaliações foram conduzidas por meio de entrevistas realizadas com gestores de cada sistema, seguindo roteiro de avaliação criado em fase piloto, devidamente validado por juízes, à luz do teste de coeficiente de validação de conteúdo - CVC. As entrevistas foram estudadas pelo método de análise de conteúdo com o apoio de estatísticas textuais. Os elementos colhidos na pesquisa permitiram a construção de um modelo de avaliação de transparência e accountability em serviços públicos digitais composto por 8 dimensões (acessibilidade; consciência; acesso e reparação; accountability; explicação; origem dos dados, privacidade e justiça; auditoria; validação, precisão e teste) e 35 itens de análise. As evidências encontradas na pesquisa demonstram uma preocupação do poder público em oferecer um serviço digital mais célere e eficiente, sem proporcionar mecanismos de transparência e accountability adequados. Os resultados indicam obstáculos técnicos e econômicos (aumento do custo e complexidade) para a promoção da consciência do usuário quanto aos passos seguidos por um serviço público digital. Os resultados obtidos e os procedimentos adotados nessa pesquisa são relevantes para a prática dos gestores públicos que desejam avaliar a transparência e accountability de serviços públicos digitais. As dimensões e itens de análise utilizados permitem esquadrinhar a transparência em serviços públicos digitais proporcionando a reaplicação futura e consequente comparação com outros serviços. A contribuição teórica pode ser creditada à combinação inédita dos critérios estudados a fim de se estudar a transparência de um serviço público digital, com vistas à promoção da accountability. Technological advances have been introducing a new type of rationalization in the public sector through the use of modern information and communication technologies (ICTs), leading to changes in public policies, processes and functions. Increasingly, public services have been made available in the digital environment, increasing the citizen's dependence on their results. Results and decisions coming from automated systems or processes are not very transparent and hard to challenge in case of undue results. The transparency and accountability of the system and algorithms aims to protect the user against undesirable or harmful results and to ensure the application of laws to the digital environment. Thus, the objective of the study is to verify the transparency and accountability provided to the citizen in digital public services (e-services) offered by the Brazilian Federal Public Administration. Adopting a qualitative approach, the research evaluated three Brazilian digital public services (ComprasNet, Sisu and Naturalizar-se) in order to evaluate the treatment that these services have been giving to transparency and accountability. The evaluations were conducted through interviews with managers of each system, following an evaluation script created in a pilot phase, validated by judges, in light of the content validation coefficient test - CVC. The interviews were studied using the content analysis method with the support of textual statistics. The elements collected in the research allowed the construction of a model for assessing transparency and accountability in digital public services composed of 8 dimensions (accessibility; awareness; access and repair; accountability; explanation; data source, privacy and justice; audit; validation, accuracy and testing) and 35 items of analysis. The evidence found in the research demonstrates a concern of the public authorities in offering a faster and more efficient digital service, without providing adequate transparency and accountability mechanisms. The results indicate technical and economic obstacles (increased cost and complexity) to promote the user's awareness of the steps followed by a digital public service. The results obtained and the procedures adopted in this research are relevant to the practice of public managers who wish to assess the transparency and accountability of digital public services. The dimensions and items of analysis make it possible to scan transparency in digital public services, providing future reapplication and consequent comparison with other services. The theoretical contribution can be credited to the unprecedented combination of the studied criteria in order to study the transparency of a digital public service, with a view to promoting accountability.
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- 2020
28. Comparing X-ray color selection in separating X-ray binary classes using Color-Color-Intensity diagrams
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Ewan O'Sullivan, A. Mossman, Jennifer Lauer, Raffaele D'Abrusco, Ginevra Trinchieri, Giuseppina Fabbiano, Douglas Morgan, Douglas Burke, Nazma Islam, Bram Boroson, C. Anderson, S. D. Vrtilek, Michael L. McCollough, Alessandro Paggi, Dong-Woo Kim, and Antonella Fruscione
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Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Stars: Black holes ,010308 nuclear & particles physics ,Astrophysics::High Energy Astrophysical Phenomena ,Color intensity ,X-ray ,X-ray binary ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Compact star ,01 natural sciences ,Universality (dynamical systems) ,Black hole ,Neutron star ,Space and Planetary Science ,Methods: Data analysis ,0103 physical sciences ,Stars: Neutron ,X-rays: Binaries ,Astrophysics - High Energy Astrophysical Phenomena ,010303 astronomy & astrophysics ,Instrumentation - Abstract
X-ray binaries exhibit a wide range of properties but there are few accepted methods to determine the nature of the compact object. Color-Color-Intensity diagrams have been suggested as a means of distinguishing between systems containing black holes from those containing neutron stars. However, this technique has been verified with data from only one instrument (RXTE/ASM) with a single set of X-ray colors defined using data available only in pre-determined energy bands. We test a selection of X-ray colors with a more sensitive instrument to determine the reliability of this method. We use data from the MAXI Gas Slit Camera, which allows users to specify energy-bands. We test X-ray colors that have been previously defined in the literature as well as ones that we define specifically in this paper. A representative set of systems are used to construct Color-Color-Intensity diagrams in each set of colors to determine which are best for separating different classes. For studying individual sources certain bands are more effective than others. For a specified energy range, the separation of soft states in black hole binaries was possible only where both soft and hard colors included information from the lowest energy band. We confirm that Color-Color-Intensity diagrams can distinguish between systems containing black holes or neutron stars in all X-ray colors tested; this suggests an universality in the accretion processes governing these different classes. We suggest possible physical processes driving different classes of X-ray binaries to different locations in Color-Color-Intensity diagrams., Comment: 23 pages, 19 figures. Accepted in New Astronomy
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- 2020
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29. Multiple sclerosis management during the COVID-19 pandemic
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Moss, Brandon P, Mahajan, Kedar R, Bermel, Robert A, Hellisz, Kelsey, Hua, Le H, Hudec, Timothy, Husak, Scott, McGinley, Marisa P, Ontaneda, Daniel, Wang, Zhini, Weber, Malory, Tagliani, Paula, Cárdenas-Robledo, Simón, Zabalza, Ana, Arrambide, Georgina, Carbonell-Mirabent, Pere, Rodríguez-Barranco, Marta, Sastre-Garriga, Jaume, Tintoré, Mar, Montalban, Xavier, Douglas, Morgan, Ogbuokiri, Esther, Aravidis, Berna, Cohen, Jeffrey A, Mowry, Ellen M, Fitzgerald, Kathryn C, and Universitat Autònoma de Barcelona
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Male ,Health Behavior ,Comorbidity ,Disease ,medicine.disease_cause ,Health Services Accessibility ,0302 clinical medicine ,Occupational Therapy ,disease modifying therapies ,Risk Factors ,Pandemic ,Disease modifying therapies ,030212 general & internal medicine ,Disease management (health) ,Home Infusion Therapy ,healthcare delivery ,Coronavirus ,Age Factors ,Disease Management ,Middle Aged ,Original Research Paper ,health behaviors ,Neurology ,Hypertension ,Educational Status ,Female ,Disease Susceptibility ,Coronavirus Infections ,Adult ,Employment ,medicine.medical_specialty ,Multiple Sclerosis ,Coronavirus disease 2019 (COVID-19) ,Pneumonia, Viral ,Healthcare delivery ,Multiple sclerosis ,Betacoronavirus ,03 medical and health sciences ,medicine ,Humans ,Immunologic Factors ,Obesity ,Intensive care medicine ,Health behaviors ,Pandemics ,Physical Therapy Modalities ,business.industry ,SARS-CoV-2 ,COVID-19 ,medicine.disease ,United States ,Social Class ,Spain ,Multivariate Analysis ,Neurology (clinical) ,business ,Delivery of Health Care ,030217 neurology & neurosurgery - Abstract
Altres ajuts: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. The development of standardized data collection as part of routine clinical care through Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) was developed and implemented at CC, JH, and CEMCAT in partnership with Biogen. Biogen did not have involvement in study design, data analysis or interpretation, or manuscript preparation. People with multiple sclerosis (MS) may be at higher risk for complications from the 2019 coronavirus (COVID-19) pandemic due to use of immunomodulatory disease modifying therapies (DMTs) and greater need for medical services. To evaluate risk factors for COVID-19 susceptibility and describe the pandemic's impact on healthcare delivery. Surveys sent to MS patients at Cleveland Clinic, Johns Hopkins, and Vall d'Hebron-Centre d'Esclerosi Múltiple de Catalunya in April and May 2020 collected information about comorbidities, DMTs, exposures, COVID-19 testing/outcomes, health behaviors, and disruptions to MS care. There were 3028/10,816 responders. Suspected or confirmed COVID-19 cases were more likely to have a known COVID-19 contact (odds ratio (OR): 4.38; 95% confidence interval (CI): 1.04, 18.54). In multivariable-adjusted models, people who were younger, had to work on site, had a lower education level, and resided in socioeconomically disadvantaged areas were less likely to follow social distancing guidelines. 4.4% reported changes to therapy plans, primarily delays in infusions, and 15.5% a disruption to rehabilitative services. Younger people with lower socioeconomic status required to work on site may be at higher exposure risk and are potential targets for educational intervention and work restrictions to limit exposure. Providers should be mindful of potential infusion delays and MS care disruption.
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- 2020
30. Transparência e accountability de algoritmos governamentais: o caso do sistema eletrônico de votação brasileiro
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SALDANHA, DOUGLAS MORGAN FULLIN, primary and SILVA, MARCELA BARBOSA DA, additional
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- 2020
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31. An XMM-Newton Early-type Galaxy Atlas
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Amy E. Mossman, Ewan O'Sullivan, Craig Anderson, Ginevra Trinchieri, Alessandro Paggi, Giuseppina Fabbiano, Nazma Islam, Kenneth Lin, Saeqa Dil Vrtilek, Jennifer Lauer, Dong-Woo Kim, and Douglas Morgan
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Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,Astronomy & Astrophysics ,Atomic ,Particle and Plasma Physics ,Atlas (anatomy) ,medicine ,Nuclear ,Astrophysics::Galaxy Astrophysics ,Physics ,Astrophysical Processes ,Conjunction (astronomy) ,Spatially resolved ,Molecular ,Astronomy and Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Galaxy ,Early type ,Interstellar medium ,medicine.anatomical_structure ,Space and Planetary Science ,Astrophysics of Galaxies (astro-ph.GA) ,Halo ,Astronomical and Space Sciences ,Physical Chemistry (incl. Structural) - Abstract
The distribution of hot interstellar medium in early-type galaxies bears the imprint of the various astrophysical processes it underwent during its evolution. The X-ray observations of these galaxies have identified various structural features related to AGN and stellar feedback and environmental effects such as merging and sloshing. In our XMM-Newton Galaxy Atlas (NGA) project, we analyze archival observations of 38 ETGs, utilizing the high sensitivity and large field of view of XMM-Newton to construct spatially resolved 2D spectral maps of the hot gas halos. To illustrate our NGA data products in conjunction with the Chandra Galaxy Atlas (Kim et al. 2019), we describe two distinct galaxies - NGC 4636 and NGC 1550, in detail. We discuss their evolutionary history with a particular focus on the asymmetric distribution of metal-enriched, low-entropy gas caused by sloshing and AGN- driven uplift. We will release the NGA data products to a dedicated website, which users can download to perform further analyses., 19 pages, 6 figures, 2 tables. Accepted for publication in ApJS. The data-products along with the quick look results are here: https://cxc.cfa.harvard.edu/GalaxyAtlas/NGA/v1/
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- 2021
32. Risk Factors for Infection and Health Impacts of the Coronavirus Disease 2019 (COVID-19) Pandemic in People With Autoimmune Diseases.
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Fitzgerald, Kathryn C, Mecoli, Christopher A, Douglas, Morgan, Harris, Samantha, Aravidis, Berna, Albayda, Jemima, Sotirchos, Elias S, Hoke, Ahmet, Orbai, Ana-Maria, Petri, Michelle, Christopher-Stine, Lisa, Baer, Alan N, Paik, Julie J, Adler, Brittany L, Tiniakou, Eleni, Timlin, Homa, Bhargava, Pavan, Newsome, Scott D, Venkatesan, Arun, and Chaudhry, Vinay
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GLUCOCORTICOIDS ,COVID-19 ,ACQUISITION of data methodology ,CONFIDENCE intervals ,INFLAMMATION ,AUTOIMMUNE diseases ,MENTAL health ,RISK assessment ,SOCIOECONOMIC factors ,MEDICAL records ,QUESTIONNAIRES ,IMMUNOLOGICAL adjuvants ,DESCRIPTIVE statistics ,HEALTH behavior ,HEALTH impact assessment ,IMMUNOSUPPRESSIVE agents ,ODDS ratio ,SOCIAL distancing ,COVID-19 pandemic ,LONGITUDINAL method ,COMORBIDITY ,DISEASE complications - Abstract
Background People with autoimmune or inflammatory conditions taking immunomodulatory/suppressive medications may have higher risk of novel coronavirus disease 2019 (COVID-19). Chronic disease care has also changed for many patients, with uncertain downstream consequences. Methods We included participants with autoimmune or inflammatory conditions followed by specialists at Johns Hopkins. Participants completed periodic surveys querying comorbidities, disease-modifying medications, exposures, COVID-19 testing and outcomes, social behaviors, and disruptions to healthcare. We assessed whether COVID-19 risk is higher among those on immunomodulating or suppressive agents and characterized pandemic-associated changes to care and mental health. Results In total, 265 (5.6%) developed COVID-19 over 9 months of follow-up (April–December 2020). Patient characteristics (age, race, comorbidity, medications) were associated with differences in social distancing behaviors during the pandemic. Glucocorticoid exposure was associated with higher odds of COVID-19 in models incorporating behavior and other potential confounders (odds ratio [OR]: 1.43; 95% confidence interval [CI]: 1.08, 1.89). Other medication classes were not associated with COVID-19 risk. Diabetes (OR: 1.72; 95% CI: 1.08, 2.73), cardiovascular disease (OR: 1.68; 95% CI: 1.24, 2.28), and kidney disease (OR: 1.76; 95% CI: 1.04, 2.97) were associated with higher odds of COVID-19. Of the 2156 reporting pre-pandemic utilization of infusion, mental health or rehabilitative services, 975 (45.2%) reported disruptions therein, which disproportionately affected individuals experiencing changes to employment or income. Conclusions Glucocorticoid exposure may increase risk of COVID-19 in people with autoimmune or inflammatory conditions. Disruption to healthcare and related services was common. Those with pandemic-related reduced income may be most vulnerable to care disruptions. [ABSTRACT FROM AUTHOR]
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- 2022
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33. Multiple sclerosis management during the COVID-19 pandemic
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Moss, Brandon P, primary, Mahajan, Kedar R, additional, Bermel, Robert A, additional, Hellisz, Kelsey, additional, Hua, Le H, additional, Hudec, Timothy, additional, Husak, Scott, additional, McGinley, Marisa P, additional, Ontaneda, Daniel, additional, Wang, Zhini, additional, Weber, Malory, additional, Tagliani, Paula, additional, Cárdenas-Robledo, Simón, additional, Zabalza, Ana, additional, Arrambide, Georgina, additional, Carbonell-Mirabent, Pere, additional, Rodríguez-Barranco, Marta, additional, Sastre-Garriga, Jaume, additional, Tintore, Mar, additional, Montalban, Xavier, additional, Douglas, Morgan, additional, Ogbuokiri, Esther, additional, Aravidis, Berna, additional, Cohen, Jeffrey A, additional, Mowry, Ellen M, additional, and Fitzgerald, Kathryn C, additional
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- 2020
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34. Overcoming nursing barriers to intensive care unit early mobilisation: A quality improvement project
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Elisabeth L. George, Dianxu Ren, Patricia K. Tuite, Oluwatobi O. Hunter, Douglas Morgan, and Margaret Rosenzweig
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Adult ,Male ,medicine.medical_specialty ,Quality management ,Adolescent ,Nurses ,Nursing knowledge ,Critical Care Nursing ,law.invention ,03 medical and health sciences ,Education, Nursing, Continuing ,0302 clinical medicine ,Nursing ,law ,Post training ,Humans ,Medicine ,Early Ambulation ,business.industry ,Outcome measures ,030208 emergency & critical care medicine ,Middle Aged ,Quality Improvement ,Intensive care unit ,Intensive Care Units ,030228 respiratory system ,Protocol Compliance ,Coronary care unit ,Physical therapy ,Female ,Training program ,business ,Program Evaluation - Abstract
To increase adherence with intensive care unit mobility by developing and implementing a mobility training program that addresses nursing barriers to early mobilisation.An intensive care unit mobility training program was developed, implemented and evaluated with a pre-test, immediate post-test and eight-week post-test. Patient mobility was tracked before and after training.A ten bed cardiac intensive care unit.The training program's efficacy was measured by comparing pre-test, immediate post-test and 8-week post-test scores. Patient mobilisation rates before and after training were compared. Protocol compliance was measured in the post training group.Nursing knowledge increased from pre-test to immediate post-test (p0.0001) and pre-test to 8-week post-test (p0.0001). Mean test scores decreased by seven points from immediate post-test (80±12) to 8-week post-test (73±14). Fear significantly decreased from pre-test to immediate post-test (p=0.03), but not from pre-test to 8-week post-test (p=0.06) or immediate post-test to 8-week post-test (p=0.46). Post training patient mobility rates increased although not significantly (p=0.07). Post training protocol compliance was 78%.The project successfully increased adherence with intensive care unit mobility and indicates that a training program could improve adoption of early mobility.
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- 2017
35. Traumatic injuries in rural Honduras: A two month pilot study
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W Tyler Winders, Ricardo L. Dominguez, Isis Ramos, Douglas Morgan, Celeny Perez, Rosa Estevez, Dalton Argean Norwood, Juan Carlos Cardona, and Willian Sabillon
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Poison control ,Pilot Projects ,Violence ,Suicide prevention ,Proof of Concept Study ,Occupational safety and health ,Young Adult ,Injury Severity Score ,Epidemiology ,Injury prevention ,medicine ,Humans ,Registries ,Child ,Aged ,Descriptive statistics ,business.industry ,Mortality rate ,Accidents, Traffic ,Human factors and ergonomics ,General Medicine ,Middle Aged ,Cross-Sectional Studies ,Honduras ,Child, Preschool ,Emergency medicine ,Emergency Medicine ,Wounds and Injuries ,Accidental Falls ,Female ,business ,Emergency Service, Hospital - Abstract
Objectives Trauma is a leading cause of morbidity and mortality worldwide, with a disproportionate burden of illness in low- and middle- income countries. This study sought to provide a proof-of-concept pilot study to evaluate the feasibility of a trauma registry in the Western Honduras Hospital. Methods A cross-sectional, observation study was performed that included all admitted, transferred, or deceased trauma patients presenting to the Western Honduras Hospital from February 4, 2019 until April 4, 2019. Descriptive statistics were utilized to describe patient demographics and injury characteristics. Results 268 patients were enrolled. The average age was 27.5 years (SD ±21.3). 10% of injuries were due to interpersonal violence. The most common mechanisms of injury were falls (33.6%) and motor vehicle collisions (MVCs) (22.4%). The mean Modified Kampala Trauma Score (M-KTS) was 12 (SD ±1.4). The mortality rate was 1.1% (N = 3). 94.5% of data points were complete. Conclusions A continuous injury surveillance system in the Western Honduras Hospital is feasible and provides valuable information. The data completeness was suboptimal, but the current data collection system may be improved via modifying and utilizing the registry form as both a clinical and data collection instrument.
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- 2019
36. AGA Institute Technical Review on Gastric Intestinal Metaplasia – Part 1
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Gawron, Andrew J., Shah, Shailja C., Altayar, Osama, Davitkov, Perica, Douglas, Morgan, Kevin, Turner, and Mustafa, Reem A.
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Article - Published
- 2019
37. A Macroscopic Charcoal and Multiproxy Record from Peat Recovered from Depression Marshes in Longleaf Pine Sandhills, Florida, USA
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Tanner, Benjamin, primary, Douglas, Morgan, additional, Greenberg, Cathryn, additional, Chamberlin, Jessica, additional, and Styers, Diane, additional
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- 2018
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38. Budgeting for Local Governments and Communities
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Douglas Morgan, Kent S. Robinson, Dennis Strachota, and James A. Hough
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- 2017
39. Budgeting for Local Governments and Communities
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Douglas Morgan, Kent S. Robinson, Dennis Strachota, James A. Hough, Douglas Morgan, Kent S. Robinson, Dennis Strachota, and James A. Hough
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- Local budgets--United States, Local finance--United States, Budget--United States
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Budgeting for Local Governments and Communities is designed as the primary textbook for a quarter or semester-long course in public budgeting and finance in an MPA programme.Many currently available texts for this course suffer from a combination of defects that include a focus on federal and state budgeting, a lack of a theoretical governance framework, an omission of important topics, and typically a lack of exercises and datasets for student use. Budgeting for Local Governments and Communities solves all of these problems.The book is exceptionally comprehensive and well written, and represents the efforts of veteran authors with both teaching and real-world experience. Key Features: Special Focus on Local Government Budgeting: focuses exclusively on budgeting at the local levels of American government, which are responsible for spending 40 percent of the taxes collected from citizens. Integration of Theory and Practice: teaching cases and chapters capture the'lessons learned'by professional practitioners who have extensive experience in making local public budgeting work on the ground. Polity Approach to Local Budgeting: presents an introduction to local budgeting as the central political activity that integrates the resources of the community into a unified whole. Budgeting is presented as governance work, rather than as a unique set of skills possessed by analysts and financial specialists. Legal, Historical, Economic and Moral Foundations of Local Government Budgeting: provides readers with an understanding of how the structures and processes of local budgeting systems are firmly tethered to the underlying core values, legal principles and historical development of the larger American federal, state and local political systems. Electronic Datasets and Budgeting Exercises: the text includes access to extensive electronic datasets and practice exercises that provide abundant opportunities for students to'learn through doing.'Extensive Glossary and Bibliography: covers terms on the history and practice of local public budgeting.
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- 2015
40. New Public Governance : A Regime-Centered Perspective
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Douglas Morgan, Brian Cook, Douglas Morgan, and Brian Cook
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- Public administration, Local government, Leadership
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Written by scholars who have been at the forefront of the NPG debate as well as by scholar-practitioners, this book provides lessons learned from experience on how networked, contract-based and partnership-centered approaches to government can be undertaken in ways that preserve the values at the center of the American constitutional and political system.
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- 2015
41. Deterioration of Cognitive Function During Cold Water Immersion is not Changed Following Repeated Exposure, Medicine & Science in Sports & Exercise
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Bailey, Stephen, Jones, Douglas Morgan, Rostomily, Kaitlyn A, Pautz, Carina M, Ito, Danica W, Buono, Michael J, Roelands, Bart, Meeusen, Romain, Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group, International Relations and Mobility, Advanced Rehabilitation Technology & Science, and Spine Research Group
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genetic structures ,musculoskeletal, neural, and ocular physiology ,behavioral disciplines and activities - Abstract
Acute cold exposure results in impaired cognitive function by diverting attention away from the primary task and reducing vigilance. Repeated exposure to cold stress induces physiological changes such as decreased skin temperature and a delayed onset of shivering in an effort to reduce heat loss and conserve energy during subsequent cold exposures. It is unclear if repeated exposure to cold attenuates the decrease in cognitive function typically seen during acute cold exposure. PURPOSE:To determine if cognitive function during acute cold exposure is changed following repeated immersions in cold water. METHODS: Eight healthy volunteers (age: 25.9 ± 6.4 years, height: 172.7 ± 6.3 cm, weight: 74.9 ± 11.4 kg) completed seven 90-minute cold water immersions in 10°C water. Subjects completed the psychomotor vigilance task (PVT) during the 1st, 4th, and 7th cold water immersion at several time points (pre, 5 min, 30 min, 60 min, 90 min). Core temperature, heart rate, skin temperature (Tsk), thermal sensation, and skin blood flow were collected during each heat trial. RESULTS: Significantly reduced skin temperature and a delayed onset of shivering were observed during the 7th cold water immersion when compared with the 1st, suggesting that acclimation to cold occurred. Reaction time (RT) (pre=263±7 msec, 5 min=268±12 msec, 30 min=278±10 msec, 60 min=294±7 msec, 90 min=291±8 msec; p
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- 2016
42. Carbapenem-Resistant Klebsiella pneumoniae Cluster Associated With Gastroscope Exposure Among Surgical Intensive Care Unit Patients at University of Pittsburgh Medical Center
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Ashley Querry, Douglas Morgan, Carlene A. Muto, Anthony W. Pasculle, and Alyssa Parr
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Pediatrics ,medicine.medical_specialty ,biology ,Carbapenem resistant Klebsiella pneumoniae ,business.industry ,Klebsiella pneumoniae ,Surgical intensive care unit ,030501 epidemiology ,Disease cluster ,biology.organism_classification ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Oncology ,Emergency medicine ,medicine ,030211 gastroenterology & hepatology ,Gastroscopes ,0305 other medical science ,business ,Carbapenem resistance - Published
- 2016
43. BINARY PROPERTIES FROM CEPHEID RADIAL VELOCITIES (CRaV)
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Joy S. Nichols, Alexey S. Rastorguev, Jennifer Lauer, Douglas Morgan, Pawel Moskalik, Nancy Remage Evans, Natalya Gorynya, L. N. Berdnikov, and H. Moritz Günther
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Physics ,Orbital speed ,Cepheid variable ,media_common.quotation_subject ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Mass ratio ,Orbital period ,Stars ,Amplitude ,Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,Range (statistics) ,Astrophysics::Solar and Stellar Astrophysics ,Eccentricity (behavior) ,Solar and Stellar Astrophysics (astro-ph.SR) ,media_common - Abstract
We have examined high accuracy radial velocities of Cepheids to determine the binary frequency. The data are largely from the CORAVEL spectrophotometer and the Moscow version, with a typical uncertainty of $\leq1$~km~s$^{-1}$, and a time span from 1 to 20 years. A systemic velocity was obtained by removing the pulsation component using a high order Fourier series. From this data we have developed a list of stars showing no orbital velocity larger than $\pm1$~km~s$^{-1}$. The binary fraction was analyzed as a function of magnitude, and yields an apparent decrease in this fraction for fainter stars. We interpret this as incompleteness at fainter magnitudes, and derive the preferred binary fraction of $29\pm8$\% ( $20\pm6$\% per decade of orbital period) from the brightest 40 stars. Comparison of this fraction in this period range (1-20 years) implies a large fraction for the full period range. This is reasonable in that the high accuracy velocities are sensitive to the longer periods and smaller orbital velocity amplitudes in the period range sampled here. Thus the Cepheid velocity sample provides a sensitive detection in the period range between short period spectroscopic binaries and resolved companions. The recent identification of $\delta$ Cep as a binary with very low amplitude and high eccentricity underscores the fact that the binary fractions we derive are lower limits, to which other low amplitude systems will probably be added. The mass ratio (q) distribution derived from ultraviolet observations of the secondary is consistent with a flat distribution for the applicable period range (1 to 20 years)., Comment: accepted for publication in AJ
- Published
- 2015
44. Chemoprevention of Gastric Carcinogenesis
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National Cancer Institute (NCI), Cancer Prevention Pharmaceuticals, Inc., and Douglas Morgan, Director, Latin America sites, Vanderbilt Institute for Global Health
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- 2024
45. Novel Screening Modality for Early Gastric Cancer
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Douglas Morgan MD, Professor of Medicine, Director, Division of Gastroenterology/ Hepatology
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- 2023
46. Chandra Early-type Galaxy Atlas.
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Dong-Woo Kim, Craig Anderson, Douglas Burke, Raffaele D’Abrusco, Giuseppina Fabbiano, Antonella Fruscione, Jennifer Lauer, Michael McCollough, Douglas Morgan, Amy Mossman, Ewan O’Sullivan, Alessandro Paggi, Saeqa Vrtilek, and Ginevra Trinchieri
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- 2019
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47. BINARY PROPERTIES FROM CEPHEID RADIAL VELOCITIES (CRaV).
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Nancy Remage Evans, Leonid Berdnikov, Jennifer Lauer, Douglas Morgan, Joy Nichols, H. Moritz Günther, Natalya Gorynya, Alexey Rastorguev, and Pawel Moskalik
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- 2015
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48. Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy.
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Gadani SP, Reyes-Mantilla M, Jank L, Harris S, Douglas M, Smith MD, Calabresi PA, Mowry EM, Fitzgerald KC, and Bhargava P
- Abstract
Background: Sphingosine-1-phosphate receptor (S1P) modulators and antiCD20 therapies impair humoral responses to SARS-CoV-2 mRNA vaccines. Whether disease modifying therapies (DMTs) for multiple sclerosis (MS) also impact T cell immune response to vaccination is unknown., Methods: In 101 people with MS, we measured humoral responses via an immunoassay to measure IgG against the COVID-19 spike S1 glycoprotein in serum. We also measured T cell responses using FluoroSpot assay for interferon gamma (IFN-γ) (Mabtech,Sweden) using cryopreserved rested PBMCs and then incubated in cRPMI with 1µg/ml of pooled peptides spanning the entire spike glycoprotein (Genscript, 2 pools; 158 peptides each). Plates were read on an AID iSpot Spectrum to determine number of spot forming cells (SFC)/10
6 PBMCs. We tested for differences in immune responses across DMTs using linear models., Findings: Humoral responses were detected in 22/39 (56.4%) participants on anti-CD20 and in 59/63 (93.6%) participants on no or other DMTs. In a subset with immune cell phenotyping (n=88; 87%), T cell responses were detected in 76/88 (86%), including 32/33 (96.9%) participants on anti-CD20 therapies. AntiCD20 therapies were associated with an increase in IFN-γ SFC counts relative to those on no DMT or other DMTs (for antiCD20 vs. no DMT: 425.9% higher [95%CI: 109.6%, 1206.6%] higher; p<0.001; for antiCD20 vs. other DMTs: 289.6% [95%CI: 85.9%, 716.6%] higher; p<0.001)., Interpretation: We identified a robust T cell response in individuals on anti-CD20 therapies despite a reduced humoral response to SARS-CoV-2 vaccination. Follow up studies are needed to determine if this translates to protection against COVID-19 infection.- Published
- 2021
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49. RISK FACTORS FOR INFECTION AND HEALTH IMPACTS OF THE COVID-19 PANDEMIC IN PEOPLE WITH AUTOIMMUNE DISEASES.
- Author
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Fitzgerald KC, Mecoli CA, Douglas M, Harris S, Aravidis B, Albayda J, Sotirchos ES, Hoke A, Orbai AM, Petri M, Christopher-Stine L, Baer AN, Paik JJ, Adler BL, Tiniakou E, Timlin H, Bhargava P, Newsome SD, Venkatesan A, Chaudhry V, Lloyd TE, Pardo CA, Stern BJ, Lazarev M, Truta B, Saidha S, Chen ES, Sharp M, Gilotra N, Kasper EK, Gelber AC, Bingham CO 3rd, Shah AA, and Mowry EM
- Abstract
Background: People with autoimmune or inflammatory conditions who take immunomodulatory/suppressive medications may have a higher risk of novel coronavirus disease 2019 (COVID-19). Chronic disease care has also changed for many patients, with uncertain downstream consequences., Objective: Assess whether COVID-19 risk is higher among those on immunomodulating or suppressive agents and characterize pandemic-associated changes to care., Design: Longitudinal registry study., Participants: 4666 individuals with autoimmune or inflammatory conditions followed by specialists in neurology, rheumatology, cardiology, pulmonology or gastroenterology at Johns Hopkins., Measurements: Periodic surveys querying comorbidities, disease-modifying medications, exposures, COVID-19 testing and outcomes, social behaviors, and disruptions to healthcare., Results: A total of 265 (5.6%) developed COVID-19 over 9 months of follow-up (April-December 2020). Patient characteristics (age, race, comorbidity, medication exposure) were associated with differences in social distancing behaviors during the pandemic. Glucocorticoid exposure was associated with higher odds of COVID-19 in multivariable models incorporating behavior and other potential confounders (OR: 1.43; 95%CI: 1.08, 1.89). Other medication classes were not associated with COVID-19 risk. Diabetes (OR: 1.72; 95%CI: 1.08, 2.73), cardiovascular disease (OR: 1.68; 95%CI: 1.24, 2.28), and chronic kidney disease (OR: 1.76; 95%CI: 1.04, 2.97) were each associated with higher odds of COVID-19. Pandemic-related disruption to care was common. Of the 2156 reporting pre-pandemic utilization of infusion, mental health or rehabilitative services, 975 (45.2%) reported disruptions. Individuals experiencing changes to employment or income were at highest odds of care disruption., Limitations: Results may not be generalizable to all patients with autoimmune or inflammatory conditions. Information was self-reported., Conclusions: Exposure to glucocorticoids may increase risk of COVID-19 in people with autoimmune or inflammatory conditions. Disruption to healthcare and related services was common. Those with pandemic-related reduced income may be most vulnerable to care disruptions.
- Published
- 2021
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50. Multiple sclerosis management during the COVID-19 pandemic.
- Author
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Moss BP, Mahajan KR, Bermel RA, Hellisz K, Hua LH, Hudec T, Husak S, McGinley MP, Ontaneda D, Wang Z, Weber M, Tagliani P, Cárdenas-Robledo S, Zabalza A, Arrambide G, Carbonell-Mirabent P, Rodríguez-Barranco M, Sastre-Garriga J, Tintore M, Montalban X, Douglas M, Ogbuokiri E, Aravidis B, Cohen JA, Mowry EM, and Fitzgerald KC
- Subjects
- Adult, Age Factors, Betacoronavirus, COVID-19, Comorbidity, Coronavirus Infections prevention & control, Delivery of Health Care, Disease Management, Disease Susceptibility, Educational Status, Female, Health Behavior, Health Services Accessibility, Home Infusion Therapy, Humans, Hypertension epidemiology, Male, Middle Aged, Multivariate Analysis, Obesity epidemiology, Pandemics prevention & control, Pneumonia, Viral prevention & control, Risk Factors, SARS-CoV-2, Spain epidemiology, United States epidemiology, Coronavirus Infections epidemiology, Employment, Immunologic Factors therapeutic use, Multiple Sclerosis therapy, Occupational Therapy, Physical Therapy Modalities, Pneumonia, Viral epidemiology, Social Class
- Abstract
Background: People with multiple sclerosis (MS) may be at higher risk for complications from the 2019 coronavirus (COVID-19) pandemic due to use of immunomodulatory disease modifying therapies (DMTs) and greater need for medical services., Objectives: To evaluate risk factors for COVID-19 susceptibility and describe the pandemic's impact on healthcare delivery., Methods: Surveys sent to MS patients at Cleveland Clinic, Johns Hopkins, and Vall d'Hebron-Centre d'Esclerosi Múltiple de Catalunya in April and May 2020 collected information about comorbidities, DMTs, exposures, COVID-19 testing/outcomes, health behaviors, and disruptions to MS care., Results: There were 3028/10,816 responders. Suspected or confirmed COVID-19 cases were more likely to have a known COVID-19 contact (odds ratio (OR): 4.38; 95% confidence interval (CI): 1.04, 18.54). In multivariable-adjusted models, people who were younger, had to work on site, had a lower education level, and resided in socioeconomically disadvantaged areas were less likely to follow social distancing guidelines. 4.4% reported changes to therapy plans, primarily delays in infusions, and 15.5% a disruption to rehabilitative services., Conclusion: Younger people with lower socioeconomic status required to work on site may be at higher exposure risk and are potential targets for educational intervention and work restrictions to limit exposure. Providers should be mindful of potential infusion delays and MS care disruption.
- Published
- 2020
- Full Text
- View/download PDF
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