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1. Author Correction: Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

Author

Liu, Lili, Khan, Atlas, Sanchez-Rodriguez, Elena, Zanoni, Francesca, Li, Yifu, Steers, Nicholas, Balderes, Olivia, Zhang, Junying, Krithivasan, Priya, LeDesma, Robert A., Fischman, Clara, Hebbring, Scott J., Harley, John B., Moncrieffe, Halima, Kottyan, Leah C., Namjou-Khales, Bahram, Walunas, Theresa L., Knevel, Rachel, Raychaudhuri, Soumya, Karlson, Elizabeth W., Denny, Joshua C., Stanaway, Ian B., Crosslin, David, Rauen, Thomas, Floege, Jürgen, Eitner, Frank, Moldoveanu, Zina, Reily, Colin, Knoppova, Barbora, Hall, Stacy, Sheff, Justin T., Julian, Bruce A., Wyatt, Robert J., Suzuki, Hitoshi, Xie, Jingyuan, Chen, Nan, Zhou, Xujie, Zhang, Hong, Hammarström, Lennart, Viktorin, Alexander, Magnusson, Patrik K. E., Shang, Ning, Hripcsak, George, Weng, Chunhua, Rundek, Tatjana, Elkind, Mitchell S. V., Oelsner, Elizabeth C., Barr, R. Graham, Ionita-Laza, Iuliana, Novak, Jan, Gharavi, Ali G., and Kiryluk, Krzysztof

Published
2023
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4. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

Author

Liu, Lili, Khan, Atlas, Sanchez-Rodriguez, Elena, Zanoni, Francesca, Li, Yifu, Steers, Nicholas, Balderes, Olivia, Zhang, Junying, Krithivasan, Priya, LeDesma, Robert A., Fischman, Clara, Hebbring, Scott J., Harley, John B., Moncrieffe, Halima, Kottyan, Leah C., Namjou-Khales, Bahram, Walunas, Theresa L., Knevel, Rachel, Raychaudhuri, Soumya, Karlson, Elizabeth W., Denny, Joshua C., Stanaway, Ian B., Crosslin, David, Rauen, Thomas, Floege, Jürgen, Eitner, Frank, Moldoveanu, Zina, Reily, Colin, Knoppova, Barbora, Hall, Stacy, Sheff, Justin T., Julian, Bruce A., Wyatt, Robert J., Suzuki, Hitoshi, Xie, Jingyuan, Chen, Nan, Zhou, Xujie, Zhang, Hong, Hammarström, Lennart, Viktorin, Alexander, Magnusson, Patrik K. E., Shang, Ning, Hripcsak, George, Weng, Chunhua, Rundek, Tatjana, Elkind, Mitchell S. V., Oelsner, Elizabeth C., Barr, R. Graham, Ionita-Laza, Iuliana, Novak, Jan, Gharavi, Ali G., and Kiryluk, Krzysztof

Published
2022
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6. After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy

Author

Floege, Jürgen, Eitner, Frank, Rauen, Thomas, Moeller, Marcus J., Weihprecht, Horst, Budde, Klemens, Peters, Harm, Elitok, Saban, Bieringer, Markus, Schindler, Ralf, Frei, Ulrich, Canaan–Kühl, Sima, Erley, Christiane, Schlieps, Karsten, Kuhlmann, Uwe, Zandvoort, Frans, Hohenstein, Bernd, Hugo, Christian, Palm, Catrin, Hilgers, Karl, Witzke, Oliver, Gross, Oliver, Panzer, Ulf, Haller, Hermann, Bertram, Anna, Sommerer, Claudia, Zeier, Martin, Wolf, Gunter, Busch, Martin, Rath, Thomas, Ziefle, Stephan, Benzing, Thomas, Grundmann, Franziska, Mertens, Peter R., Westphalen, Stefan, Benck, Urs, Göttmann, Uwe, Vielhauer, Volker, Fischereder, Michael, Sarkar, Oliver, Stefanidou, Marianna, Mann, Johannes F.E., Otte, Britta, Pavenstädt, Hermann, Banas, Bernhard, Boeger, Alexander, Heyne, Nils, Artunc, Ferruh, Reichel, Helmut, Mettang, Thomas, Wanner, Christoph, Metzger, Thomas, Wied, Stephanie, Fitzner, Christina, and Hilgers, Ralf-Dieter

Published
2020
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9. The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats

Author

Kraehling, Jan R., primary, Benardeau, Agnes, additional, Schomber, Tibor, additional, Popp, Laura, additional, Vienenkoetter, Julia, additional, Ellinger-Ziegelbauer, Heidrun, additional, Pavkovic, Mira, additional, Hartmann, Elke, additional, Siudak, Krystyna, additional, Freyberger, Alexius, additional, Hagelschuer, Ina, additional, Mathar, Ilka, additional, Hueser, Joerg, additional, Hahn, Michael G., additional, Geiss, Volker, additional, Eitner, Frank, additional, and Sandner, Peter, additional

Published
2023
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10. International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology

Author

Nangaku, Masaomi, primary, Kitching, A. Richard, additional, Boor, Peter, additional, Fornoni, Alessia, additional, Floege, Jürgen, additional, Coates, P. Toby, additional, Himmelfarb, Jonathan, additional, Lennon, Rachel, additional, Anders, Hans-Joachim, additional, Humphreys, Benjamin D., additional, Caskey, Fergus J., additional, Fogo, Agnes B., additional, Angeletti, Andrea, additional, Bedard, Patricia W., additional, Benigni, Ariela, additional, Granqvist, Anna Björnson, additional, Chabova, Vera Certikova, additional, Chatziantoniou, Christos, additional, Cross, Jennifer, additional, Damster, Sandrine, additional, Donner, Jo-Ann, additional, Eitner, Frank, additional, Faguer, Stanislas, additional, Fontanella, Antonio, additional, Fujimoto, Yuri, additional, Gaut, Joseph, additional, Gewin, Leslie, additional, Hansen, Pernille B.L., additional, He, John Cijiang, additional, Hughes, Jeremy, additional, Inagi, Reiko, additional, Jenkinson, Celia, additional, Jha, Vivekanand, additional, Kato, Mikio, additional, Kelly, Darren, additional, Kopp, Jeffrey, additional, Korstanje, Ron, additional, Mačiulaitis, Romaldas, additional, Mark, Patrick B., additional, Marti, Hans-Peter, additional, McAdoo, Stephen P., additional, Miner, Jeffrey H., additional, Ortiz, Alberto, additional, Parikh, Samir M., additional, Pozzi, Ambra, additional, Romagnani, Paola, additional, Ronco, Pierre, additional, Rovin, Brad H., additional, Saez-Rodriguez, Julio, additional, Saleem, Moin A., additional, Sayer, John A., additional, Shankland, Stuart, additional, Shaw, Andrey S., additional, Suzuki, Yusuke, additional, Takano, Tomoko, additional, Tang, Sydney, additional, Tolba, Rene, additional, Viel, John, additional, Yamada, Yoshihisa, additional, Yanagita, Motoko, additional, Yokoo, Takashi, additional, Yoshida, Nobuya, additional, Yuen, Darren, additional, Zent, Roy, additional, and Zhang, Aihua, additional

Published
2023
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11. International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology

Author

Angeletti, Andrea, Bedard, Patricia W., Benigni, Ariela, Granqvist, Anna Björnson, Chabova, Vera Certikova, Chatziantoniou, Christos, Claure-Del Granado, Rolando, Cross, Jennifer, Damster, Sandrine, Donner, Jo-Ann, Eitner, Frank, Faguer, Stanislas, Fontanella, Antonio, Fujimoto, Yuri, Gaut, Joseph, Gewin, Leslie, Hansen, Pernille B.L., He, John Cijiang, Hughes, Jeremy, Inagi, Reiko, Jenkinson, Celia, Jha, Vivekanand, Kato, Mikio, Kelly, Darren, Kopp, Jeffrey, Korstanje, Ron, Mačiulaitis, Romaldas, Mark, Patrick B., Marti, Hans-Peter, McAdoo, Stephen P., Miner, Jeffrey H., Ortiz, Alberto, Parikh, Samir M., Pozzi, Ambra, Romagnani, Paola, Ronco, Pierre, Rovin, Brad H., Saez-Rodriguez, Julio, Saleem, Moin A., Sayer, John A., Shankland, Stuart, Shaw, Andrey S., Soler, Maria José, Suzuki, Yusuke, Takano, Tomoko, Tang, Sydney, Tolba, Rene, Ulasi, Ifeoma, Viel, John, Yamada, Yoshihisa, Yanagita, Motoko, Yokoo, Takashi, Yoshida, Nobuya, Yuen, Darren, Zent, Roy, Zhang, Aihua, Nangaku, Masaomi, Kitching, A. Richard, Boor, Peter, Fornoni, Alessia, Floege, Jürgen, Coates, P. Toby, Himmelfarb, Jonathan, Lennon, Rachel, Anders, Hans-Joachim, Humphreys, Benjamin D., Caskey, Fergus J., and Fogo, Agnes B.

Published
2023
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14. BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor

Author

Meibom, Daniel, primary, Micus, Sina, additional, Andreevski, Anna Lena, additional, Anlauf, Sonja, additional, Bogner, Pamela, additional, von Buehler, Clemens-Jeremias, additional, Dieskau, André P., additional, Dreher, Jan, additional, Eitner, Frank, additional, Fliegner, Daniela, additional, Follmann, Markus, additional, Gericke, Kersten Matthias, additional, Maassen, Stefanie, additional, Meyer, Jutta, additional, Schlemmer, Karl-Heinz, additional, Steuber, Holger, additional, Tersteegen, Adrian, additional, and Wunder, Frank, additional

Published
2022
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16. Sirolimus in renal transplant recipients with malignancies in Germany

Author

Naik, Marcel G., Arns, Wolfgang, Budde, Klemens, Diekmann, Fritz, Eitner, Frank, Gwinner, Wilfried, Heyne, Nils, Jürgensen, Jan Steffen, Morath, Christian, Riester, Udo, Heller, Katharina M., Fischereder, Michael, and German Sirolimus Study Group

Subjects
immunosuppression, sirolimus, graft survival, cancer, kidney transplantation, Original Articles, AcademicSubjects/MED00340, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, multicentre study, survival analysis
Abstract

Clinical kidney journal 14(9), 2047-2058 (2021). doi:10.1093/ckj/sfaa262, Published by Oxford Univ. Press, Oxford

Published
2020

18. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

Author

Liu, Lili, primary, Khan, Atlas, additional, Sanchez-Rodriguez, Elena, additional, Zanoni, Francesca, additional, Li, Yifu, additional, Steers, Nicholas, additional, Balderes, Olivia, additional, Zhang, Junying, additional, Krithivasan, Priya, additional, LeDesma, Robert A., additional, Fischman, Clara, additional, Hebbring, Scott J., additional, Harley, John B., additional, Moncrieffe, Halima, additional, Kottyan, Leah C., additional, Namjou-Khales, Bahram, additional, Walunas, Theresa L., additional, Knevel, Rachel, additional, Raychaudhuri, Soumya, additional, Karlson, Elizabeth W., additional, Denny, Joshua C., additional, Stanaway, Ian B., additional, Crosslin, David, additional, Rauen, Thomas, additional, Floege, Jurgen, additional, Eitner, Frank, additional, Moldoveanu, Zina, additional, Reily, Colin, additional, Knoppova, Barbora, additional, Hall, Stacy, additional, Sheff, Justin T., additional, Julian, Bruce A., additional, Wyatt, Robert J., additional, Suzuki, Hitoshi, additional, Xie, Jingyuan, additional, Chen, Nan, additional, Zhou, Xujie, additional, Zhang, Hong, additional, Hammarstrom, Lennart, additional, Viktorin, Alexander, additional, Magnusson, Patrik K. E., additional, Shang, Ning, additional, Hripcsak, George, additional, Weng, Chunhua, additional, Rundek, Tatjana, additional, Elkind, Mitchell S. V., additional, Oelsner, Elizabeth C., additional, Barr, R. Graham, additional, Ionita-Laza, Iuliana, additional, Novak, Jan, additional, Gharavi, Ali G., additional, and Kiryluk, Krzysztof, additional

Published
2021
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21. Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney

Author

Stehle, Daniel, primary, Xu, Min Ze, additional, Schomber, Tibor, additional, Hahn, Michael G., additional, Schweda, Frank, additional, Feil, Susanne, additional, Kraehling, Jan R., additional, Eitner, Frank, additional, Patzak, Andreas, additional, Sandner, Peter, additional, Feil, Robert, additional, and Bénardeau, Agnès, additional

Published
2021
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22. Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: the German Chronic Kidney Disease (GCKD) study

Author

Jing, Jiaojiao, Kielstein, Jan T., Schultheiss, Ulla T., Sitter, Thomas, Titze, Stephanie I., Schaeffner, Elke S., McAdams-DeMarco, Mara, Kronenberg, Florian, Eckardt, Kai-Uwe, Köttgen, Anna, Eckardt, Kai-Uwe, Titze, Stephanie, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Reis, André, Ekici, Arif B., Gefeller, Olaf, Hilgers, Karl F., Hübner, Silvia, Avendaño, Susanne, Becker-Grosspitsch, Dinah, Hauck, Nina, Seuchter, Susanne A., Hausknecht, Birgit, Rittmeier, Marion, Weigel, Anke, Beck, Andreas, Ganslandt, Thomas, Knispel, Sabine, Dressel, Thomas, Malzer, Martina, Floege, Jürgen, Eitner, Frank, Schlieper, Georg, Findeisen, Katharina, Arweiler, Elfriede, Ernst, Sabine, Unger, Mario, Lipski, Stefan, Schaeffner, Elke, Baid-Agrawal, Seema, Petzold, Kerstin, Schindler, Ralf, Köttgen, Anna, Schultheiss, Ulla, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Walz, Gerd, Haller, Hermann, Lorenzen, Johan, Kielstein, Jan T., Otto, Petra, Sommerer, Claudia, Föllinger, Claudia, Zeier, Martin, Wolf, Gunter, Busch, Martin, Paul, Katharina, Dittrich, Lisett, Sitter, Thomas, Hilge, Robert, Blank, Claudia, Wanner, Christoph, Krane, Vera, Schmiedeke, Daniel, Toncar, Sebastian, Cavitt, Daniela, Schönowsky, Karina, Börner-Klein, Antje, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weiensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, and Schmid, Matthias

Published
2015
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23. Disease burden and risk profile in referred patients with moderate chronic kidney disease: composition of the German Chronic Kidney Disease (GCKD) cohort

Author

Titze, Stephanie, Schmid, Matthias, Köttgen, Anna, Busch, Martin, Floege, Jürgen, Wanner, Christoph, Kronenberg, Florian, Eckardt, Kai-Uwe, Eckardt, Kai-Uwe, Titze, Stephanie, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Ganslandt, Thomas, Gefeller, Olaf, Schmid, Matthias, Köster, Jan, Malzer, Martina, Schlieper, Georg, Eitner, Frank, Meisen, Sabine, Kehl, Katharina, Arweiler, Elfriede, Floege, Jürgen, Schaeffner, Elke, Baid-Agrawal, Seema, Schindler, Ralf, Titze, Stephanie, Hübner, Silvia, Dienemann, Thomas, Hilgers, Karl F., Eckardt, Kai-Uwe, Köttgen, Anna, Schulthei, Ulla, Walz, Gerd, Kielstein, Jan T., Lorenzen, Johan, Haller, Hermann, Sommerer, Claudia, Zeier, Martin, Busch, Martin, Paul, Katharina, Wolf, Gunter, Hilge, Robert, Sitter, Thomas, Krane, Vera, Schmiedeke, Daniel, Toncar, Sebastian, Wanner, Christoph, Ekici, Arif B., Reis, André, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Kollertits, Barbara, Raschenberger, Julia, Kronenberg, Florian, Gronwald, Wolfram, Zacharias, Helena, and Oefner, Peter

Published
2015
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24. Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)

Author

Hahn, Michael G., primary, Lampe, Thomas, additional, El Sheikh, Sherif, additional, Griebenow, Nils, additional, Woltering, Elisabeth, additional, Schlemmer, Karl-Heinz, additional, Dietz, Lisa, additional, Gerisch, Michael, additional, Wunder, Frank, additional, Becker-Pelster, Eva-Maria, additional, Mondritzki, Thomas, additional, Tinel, Hanna, additional, Knorr, Andreas, additional, Kern, Armin, additional, Lang, Dieter, additional, Hueser, Joerg, additional, Schomber, Tibor, additional, Benardeau, Agnes, additional, Eitner, Frank, additional, Truebel, Hubert, additional, Mittendorf, Joachim, additional, Kumar, Vijay, additional, van den Akker, Focco, additional, Schaefer, Martina, additional, Geiss, Volker, additional, Sandner, Peter, additional, and Stasch, Johannes-Peter, additional

Published
2021
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25. Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney.

Author

Stehle, Daniel, Xu, Min Ze, Schomber, Tibor, Hahn, Michael G., Schweda, Frank, Feil, Susanne, Kraehling, Jan R., Eitner, Frank, Patzak, Andreas, Sandner, Peter, Feil, Robert, and Bénardeau, Agnès

Subjects
GUANYLATE cyclase, VASODILATION, CHRONIC kidney failure, KIDNEYS, KIDNEY physiology, BLOOD flow
Abstract

Background and Purpose: Generation of cGMP via NO‐sensitive soluble guanylyl cyclase (sGC) has been implicated in the regulation of renal functions. Chronic kidney disease (CKD) is associated with decreased NO bioavailability, increased oxidative stress and oxidation of sGC to its haem‐free form, apo‐sGC. Apo‐sGC cannot be activated by NO, resulting in impaired cGMP signalling that is associated with chronic kidney disease progression. We hypothesised that sGC activators, which activate apo‐sGC independently of NO, increase renal cGMP production under conditions of oxidative stress, thereby improving renal blood flow (RBF) and kidney function. Experimental Approach Two novel sGC activators, runcaciguat and BAY‐543, were tested on murine kidney. We measured cGMP levels in real time in kidney slices of cGMP sensor mice, vasodilation of pre‐constricted glomerular arterioles and RBF in isolated perfused kidneys. Experiments were performed at baseline conditions, under L‐NAME‐induced NO deficiency, and in the presence of oxidative stress induced by ODQ. Key Results: Mouse glomeruli showed NO‐induced cGMP increases. Under baseline conditions, sGC activator did not alter glomerular cGMP concentration or NO‐induced cGMP generation. In the presence of ODQ, NO‐induced glomerular cGMP signals were markedly reduced, whereas sGC activator induced strong cGMP increases. L‐NAME and ODQ pretreated isolated glomerular arterioles were strongly dilated by sGC activator. sGC activator also increased cGMP and RBF in ODQ‐perfused kidneys. Conclusion and Implication: sGC activators increase glomerular cGMP, dilate glomerular arterioles and improve RBF under disease‐relevant oxidative stress conditions. Therefore, sGC activators represent a promising class of drugs for chronic kidney disease treatment. LINKED ARTICLES: This article is part of a themed issue on cGMP Signalling in Cell Growth and Survival. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.11/issuetoc [ABSTRACT FROM AUTHOR]

Published
2022
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30. Determinants of Successful Use of Sirolimus in Renal Transplant Patients

Author

Naik, Marcel G., primary, Jürgensen, Jan Steffen, additional, Arns, Wolfgang, additional, Basic, Edin, additional, Budde, Klemens, additional, Eitner, Frank, additional, Fischereder, Michael, additional, Goßmann, Jan, additional, Heller, Katharina M., additional, Heyne, Nils, additional, Morath, Christian, additional, Riester, Udo, additional, Diekmann, Fritz, additional, and Gwinner, Wilfried, additional

Published
2020
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31. After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy

Author

Rauen, Thomas, primary, Wied, Stephanie, additional, Fitzner, Christina, additional, Eitner, Frank, additional, Sommerer, Claudia, additional, Zeier, Martin, additional, Otte, Britta, additional, Panzer, Ulf, additional, Budde, Klemens, additional, Benck, Urs, additional, Mertens, Peter R., additional, Kuhlmann, Uwe, additional, Witzke, Oliver, additional, Gross, Oliver, additional, Vielhauer, Volker, additional, Mann, Johannes F.E., additional, Hilgers, Ralf-Dieter, additional, Floege, Jürgen, additional, Rauen, Thomas, additional, Moeller, Marcus J., additional, Weihprecht, Horst, additional, Peters, Harm, additional, Elitok, Saban, additional, Bieringer, Markus, additional, Schindler, Ralf, additional, Frei, Ulrich, additional, Canaan–Kühl, Sima, additional, Erley, Christiane, additional, Schlieps, Karsten, additional, Zandvoort, Frans, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Palm, Catrin, additional, Hilgers, Karl, additional, Haller, Hermann, additional, Bertram, Anna, additional, Wolf, Gunter, additional, Busch, Martin, additional, Rath, Thomas, additional, Ziefle, Stephan, additional, Benzing, Thomas, additional, Grundmann, Franziska, additional, Westphalen, Stefan, additional, Göttmann, Uwe, additional, Fischereder, Michael, additional, Sarkar, Oliver, additional, Stefanidou, Marianna, additional, Pavenstädt, Hermann, additional, Banas, Bernhard, additional, Boeger, Alexander, additional, Heyne, Nils, additional, Artunc, Ferruh, additional, Reichel, Helmut, additional, Mettang, Thomas, additional, Wanner, Christoph, additional, and Metzger, Thomas, additional

Published
2020
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34. Comparison of different measurement methods of cGMP

Author

Kremser, Marcel, Winkler, Steffen, Eitner, Frank, Bénardeau, Agnes, and Kraehling, Jan Robert

Subjects
education, ddc:610, humanities, health care economics and organizations
Abstract

9th International Conference on cGMP, Mainz, Germany, 14 Jun 2019 - 16 Jun 2019; Journal of translational medicine 17(Supplement 2), P22 (2019). special issue: "Meeting abstracts from the 9th International Conference on cGMP: Generators, Effectors and Therapeutic Implications", Published by BioMed Central, London

Published
2019

35. Sirolimus in renal transplant recipients with malignancies in Germany.

Author

Naik, Marcel G, Arns, Wolfgang, Budde, Klemens, Diekmann, Fritz, Eitner, Frank, Gwinner, Wilfried, Heyne, Nils, Jürgensen, Jan Steffen, Morath, Christian, Riester, Udo, Heller, Katharina M, and Fischereder, Michael

Subjects
SKIN cancer, KIDNEY transplantation, BOWEN'S disease, OVERALL survival, RAPAMYCIN, BASAL cell carcinoma
Abstract

Background Renal transplant recipients have an increased cancer risk. The mammalian target of rapamycin inhibitor sirolimus (SRL) has immunosuppressive and antitumour activities but knowledge about its use in recipients with cancer is limited. Methods We retrospectively analysed 726 renal allograft recipients converted to SRL from 10 German transplant centres. Patient and graft survival were analysed depending on malignancy status prior to conversion and tumour entity. Results Malignancy before conversion to SRL was reported in 230 patients, with 137 patients having skin cancers and 101 having solid cancers. Cancer occurred 4.6 ± 9.4 (median 3.0) years after transplantation. Basal cell carcinoma, squamous cell carcinoma and Bowen's disease were the most prevalent skin cancers, while carcinomas of the kidney, colon and breast were the most prevalent solid cancers before conversion. Patients with prior malignancy were older and had better renal function at conversion compared with patients without a history of cancer. After conversion to SRL, cancer incidence rates (IRs) of all tumours were lower compared with rates before conversion. Cancer IRs after conversion were higher in patients with malignancy before conversion compared with those without. Patient survival was worse in patients with solid cancers compared with patients with skin cancers or without malignancies. Biopsy-proven acute rejections in the first year after conversion were less frequent in patients with malignancy compared with those without. Graft survival and renal function in all cancer types were better than in patients converted to SRL without cancers. Conclusions Conversion to SRL in patients with a history of cancer is safe regarding renal function and graft survival, while patient survival is largely dependent on tumour entity. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Prevalence, phenotypic characteristics and prognostic role of apparent treatment resistant hypertension in the German Chronic Kidney Disease (GCKD) study

Author

Mielke, Johanna, Trucks-Jansen, Holger, Schurmann, Claudia, Kotsis, Fruzsina, Köttgen, Anna, Schneider, Markus P., Eckardt, Kai-Uwe, Freitag, Daniel F., Eitner, Frank, and Becker, Michael S.

Abstract

Treatment resistant hypertension (TRH) appears of particular relevance in patients with chronic kidney disease (CKD). However, causes and consequences of TRH in CKD patients remain incompletely understood. Therefore, we analyzed the prevalence of apparent TRH (aTRH), and phenotypic characteristics and prognosis associated with aTRH among participants of the German Chronic Kidney Disease (GCKD) study. As insufficient medication adherence has been shown to be a frequent cause of pseudoresistance, we also assessed treatment adherence. Study participants were classified as having aTRH, controlled hypertension and uncontrolled hypertension based on study visit blood pressure and self-reported medication intake. Drug adherence was assessed by comparing self-reported antihypertensive medication with detectable urinary drug metabolites measured by mass spectroscopy. Out of 4901 individuals included in this study, 38% were classified as having aTRH. Male sex, older age, lower estimated glomerular filtration rate (eGFR), higher body mass index (BMI), higher urine albumin-to-creatinine ratio (UACR) and presence of diabetes mellitus were independently associated with higher prevalence of aTRH in a multivariable adjusted regression model. Patients classified as aTRH had higher risk for major adverse cardiovascular events and worsening of kidney disease compared to patients with no aTRH after multivariate adjustment for potential confounders. There was a high agreement between self-reported medication and detectable urinary drug metabolites. In conclusion, in a cohort of Caucasian patients with moderately severe CKD, aTRH was highly prevalent and, in most cases, likely not caused by low medication adherence. Furthermore, aTRH was linked to cardio-renal endpoints, emphasizing the need for improved management.

Published
2022
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37. Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils.

Author

Frei, Robert, Nordlohne, Johannes, Hüser, Ulrike, Hild, Seda, Schmidt, Johannes, Eitner, Frank, and Grundmann, Manuel

Subjects
NEUTROPHILS, G protein coupled receptors, FREE fatty acids, CHEMOKINE receptors, PROPIONIC acid
Abstract

The G protein‐coupled free fatty acid receptor 2 (FFA2R) is highly expressed on neutrophils and was previously described to regulate neutrophil activation. Allosteric targeting of G protein‐coupled receptors (GPCRs) is increasingly explored to create distinct pharmacology compared to endogenous, orthosteric ligands. The consequence of allosteric versus orthosteric FFA2R activation for neutrophil response, however, is currently largely elusive. Here, different FFA2R desensitization profiles in human neutrophils following allosteric or orthosteric activation are reported. Using a set of neutrophil functional assays to measure calcium flux, pERK1/2, chemotaxis, cellular degranulation, and oxidative burst together with holistic and pathway‐unbiased whole cell sensing based on dynamic mass redistribution, it is found that the synthetic positive allosteric modulator agonist 4‐CMTB potently activates neutrophils and simultaneously alters FFA2R responsiveness toward the endogenous, orthosteric agonist propionic acid (C3) after homologous and heterologous receptor desensitization. Stimulation with C3 or the hierarchically superior chemokine receptor activator IL‐8 led to strong FFA2R desensitization and rendered neutrophils unresponsive toward repeated stimulation with C3. In contrast, stimulation with allosteric 4‐CMTB engaged a distinct composition of signaling pathways as compared to orthosteric receptor activation and was able to activate neutrophils that underwent homologous and heterologous desensitization with C3 and IL‐8, respectively. Moreover, allosteric FFA2R activation could re‐sensitize FFA2 toward the endogenous agonist C3 after homologous and heterologous desensitization. Given the fact that receptor desensitization is critical in neutrophils to sense and adapt to their current environment, these findings are expected to be useful for the discovery of novel pharmacological mechanisms to modulate neutrophil responsiveness therapeutically. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension

Author

van Roeyen, Claudia R.C., primary, Martin, Ina V., additional, Drescher, Ana, additional, Schuett, Katharina A., additional, Hermert, Daniela, additional, Raffetseder, Ute, additional, Otten, Stephanie, additional, Buhl, Eva M., additional, Braun, Gerald S., additional, Kuppe, Christoph, additional, Liehn, Elisa, additional, Boor, Peter, additional, Weiskirchen, Ralf, additional, Eriksson, Ulf, additional, Gross, Oliver, additional, Eitner, Frank, additional, Floege, Jürgen, additional, and Ostendorf, Tammo, additional

Published
2019
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41. Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.

Author

Unterschemmann, Kerstin, Ehrmann, Alexander, Herzig, Ina, Andreevski, Anna-Lena, Lustig, Klemens, Schmeck, Carsten, Eitner, Frank, and Grundmann, Manuel

Subjects
CHRONIC kidney failure, ACUTE kidney failure, CLINICAL pharmacology, OXIDATIVE stress, REACTIVE oxygen species
Abstract

Oxidative stress is a key concept in basic, translational, and clinical research to understand the pathophysiology of various disorders, including cardiovascular and renal diseases. Although attempts to directly reduce oxidative stress with redox-active substances have until now largely failed to prove clinical benefit, indirect approaches to combat oxidative stress enzymatically have gained further attention as potential therapeutic strategies. The pantetheinase Vanin-1 is expressed on kidney proximal tubular cells, and its reaction product cysteamine is described to negatively affect redox homeostasis by inhibiting the replenishment of cellular antioxidative glutathione stores. Vanin-1-deficient mice were shown to be protected against oxidative stress damage. The aim of this study was to elucidate whether pharmacological inhibition of Vanin-1 protects mice from oxidative stress-related acute or chronic kidney injury as well. By studying renal ischemia-reperfusion injury in Col4a3-/- (Alport syndrome) mice and in vitro hypoxia-reoxygenation in human proximal tubular cells we found that treatment with a selective and potent Vanin-1 inhibitor resulted in ample inhibition of enzymatic activity in vitro and in vivo. However, surrogate parameters of metabolic and redox homeostasis were only partially and insufficiently affected. Consequently, apoptosis and reactive oxygen species level in tubular cells as well as overall kidney function and fibrotic processes were not improved by Vanin-1 inhibition. We thus conclude that Vanin-1 functionality in the context of cardiovascular diseases needs further investigation and the biological relevance of pharmacological Vanin-1 inhibition for the treatment of kidney diseases remains to be proven. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Monitoring transcellular fluid shifts during episodes of intradialytic hypotension using bioimpedance spectroscopy.

Author

Ismail, Abdul Hamid, Gross, Theresa, Schlieper, Georg, Walter, Marian, Eitner, Frank, Floege, Jürgen, and Leonhardt, Steffen

Subjects
SYSTOLIC blood pressure, EXTRACELLULAR fluid, HYPOTENSION, SPECTROMETRY, FLUIDS
Abstract

Background Transcellular fluid shifts during dialysis treatment could be related to the frequency and severity of intradialytic hypotension (IDH). We investigated that (i) in addition to ultrafiltration, extracellular fluid (ECF) is further depleted by transcellular fluid shifts and (ii) changes in intracellular fluid (ICF), which have been overlooked so far, or if they were considered, are not understood, might be due to these fluid shifts. Methods Thirty-six patients were categorized as haemodynamically stable, asymptomatic IDH or unstable (symptomatic IDH) according to their changes in systolic blood pressure and associated clinical symptoms. Their intradialytic changes in body fluids were studied using bioimpedance spectroscopy measurements and compared among groups. Results For IDH-prone patients, data showed a rapid drop in ECF that was more than expected from the ultrafiltration rate (UFR) profile and was associated with a significant increase in ICF (P = 0.001). Study of accumulative loss profiles of ECF revealed a loss in ECF up to 300 ml, more than that predicted from UFR for unstable patients. Conclusions The considerable discrepancy between the expected and measured loss in ECF might provide evidence of transcellular fluid shifts possibly induced by changes in plasma osmolarity due to haemodialysis. Moreover, the results suggest a pattern of fluid removal in IDH-prone patients that significantly differs from that in haemodynamically stable patients. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Patients with IgA nephropathy exhibit high systemic PDGF-DD levels

Author

Boor, Peter, Eitner, Frank, Cohen, Clemens D., Lindenmeyer, Maja T., Mertens, Peter R., Ostendorf, Tammo, and Floege, Jürgen

Subjects
urologic and male genital diseases
Abstract

Background. Platelet-derived growth factor (PDGF) is a central mediator of mesangioproliferative glomerulonephritis (GN). In experimental mesangioproliferative GN, PDGF-DD serum levels, unlike PDGF-BB, increased up to 1000-fold. Methods. We assessed disease activity in 72 patients with GN, established a novel PDGF-D ELISA and then determined their PDGF-DD levels. In parallel, we studied renal PDGF-DD mRNA expression by RT-PCR. Results. PDGF-DD serum levels in patients with IgA nephropathy (IgAN) were significantly higher (1.67 ± 0.45 ng/ml) and in patients with lupus nephritis significantly lower (0.66 ± 0.86 ng/ml) compared to healthy controls (1.17 ± 0.46 ng/ml), while patients with focal segmental glomerulosclerosis, membranous GN and ANCA-positive vasculitis did not differ from controls. The subgroup of IgAN patients with elevated PDGF-DD levels (27% of samples) did not differ in their clinical features from those with normal PDGF-DD levels. In IgAN patients with repetitive PDGF-DD determinations, most exhibited only minor fluctuations of serum levels over time. Intrarenal PDGF-DD mRNA expression did not differ between controls and patients, suggesting an extrarenal source of the elevated PDGF-DD in IgAN. Conclusions. Serum PDGF-DD levels were specifically elevated in patients with IgAN, in particular in those with early disease, i.e. preserved renal function. Our data support the rationale for anti-PDGF-DD therapy in mesangioproliferative GN

Published
2017

47. Effects of Two Immunosuppressive Treatment Protocols for IgA Nephropathy

Author

Rauen, Thomas, primary, Fitzner, Christina, additional, Eitner, Frank, additional, Sommerer, Claudia, additional, Zeier, Martin, additional, Otte, Britta, additional, Panzer, Ulf, additional, Peters, Harm, additional, Benck, Urs, additional, Mertens, Peter R., additional, Kuhlmann, Uwe, additional, Witzke, Oliver, additional, Gross, Oliver, additional, Vielhauer, Volker, additional, Mann, Johannes F.E., additional, Hilgers, Ralf-Dieter, additional, and Floege, Jürgen, additional

Published
2017
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48. GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

Author

Kiryluk, Krzysztof, primary, Li, Yifu, additional, Moldoveanu, Zina, additional, Suzuki, Hitoshi, additional, Reily, Colin, additional, Hou, Ping, additional, Xie, Jingyuan, additional, Mladkova, Nikol, additional, Prakash, Sindhuri, additional, Fischman, Clara, additional, Shapiro, Samantha, additional, LeDesma, Robert A., additional, Bradbury, Drew, additional, Ionita-Laza, Iuliana, additional, Eitner, Frank, additional, Rauen, Thomas, additional, Maillard, Nicolas, additional, Berthoux, Francois, additional, Floege, Jürgen, additional, Chen, Nan, additional, Zhang, Hong, additional, Scolari, Francesco, additional, Wyatt, Robert J., additional, Julian, Bruce A., additional, Gharavi, Ali G., additional, and Novak, Jan, additional

Published
2017
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49. Opponent's comments

Author

Rauen, Thomas, primary, Eitner, Frank, additional, Fitzner, Christina, additional, and Floege, Jürgen, additional

Published
2016
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50. Heart failure in a cohort of patients with chronic kidney disease: the GCKD study

Author

Beck, Hanna, Titze, Stephanie I., Hübner, Silvia, Busch, Martin, Schlieper, Georg Rainer, Schultheiss, Ulla T., Wanner, Christoph, Kronenberg, Florian, Krane, Vera, Eckardt, Kai-Uwe, Köttgen, Anna, GCKD Investigators, Titze, Stephanie, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Reis, André, Ekici, Arif B., Gefeller, Olaf, Hilgers, Karl F., Avendaño, Susanne, Becker-Grosspitsch, Dinah, Hauck, Nina, Seuchter, Susanne A., Hausknecht, Birgit, Rittmeier, Marion, Weigel, Anke, Beck, Andreas, Ganslandt, Thomas, Knispel, Sabine, Dressel, Thomas, Malzer, Martina, Flöge, Jürgen, Eitner, Frank, Findeisen, Katharina, Arweiler, Elfriede Christel, Ernst, Sabine, Unger, Mario, Lipski, Stefan, Schaeffner, Elke, Baid-Agrawal, Seema, Petzold, Kerstin, Schindler, Ralf, Schultheiss, Ulla, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Walz, Gerd, Haller, Hermann, Lorenzen, Johan, Kielstein, Jan T., Otto, Petra, Sommerer, Claudia, Föllinger, Claudia, Zeier, Martin, Wolf, Gunter, Paul, Katharina, Dittrich, Lisett, Sitter, Thomas, Hilge, Robert, Blank, Claudia, Schmiedeke, Daniel, Toncar, Sebastian, Cavitt, Daniela, Schönowsky, Karina, Börner-Klein, Antje, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weißensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, Schmid, Matthias, and GCKD Investigators

Subjects
medicine.medical_specialty, Anemia, 610 Medizin, Renal function, lcsh:Medicine, Medizinische Fakultät, Internal medicine, Epidemiology, Medicine, ddc:610, Risk factor, Prospective cohort study, lcsh:Science, Multidisciplinary, business.industry, lcsh:R, medicine.disease, Endocrinology, Heart failure, Cohort, lcsh:Q, business, Research Article, Kidney disease
Abstract

PLoS one 10(4), e0122552 (2015). doi:10.1371/journal.pone.0122552, Published by PLoS, Lawrence, Kan.

Published
2015

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