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10 results on '"Ellen van der Schoot C"'

1. Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Author

Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Spinello, Antinori, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, de Jongh, Willem A., Salanti, Ali, Theander, Thor G., McCall, Matthew B.B., Esen, Meral, Van Coillie, Julie, Pongracz, Tamas, Šuštić, Tonći, Wang, Wenjun, Nouta, Jan, Le Gars, Mathieu, Keijzer, Sofie, Linty, Federica, Cristianawati, Olvi, Keijser, Jim B.D., Visser, Remco, Smit, Merel J., Sander, Adam, Schmidt, David E., Steenhuis, Maurice, Rispens, Theo, Nielsen, Morten A., Mordmüller, Benjamin G., Ellen van der Schoot, C., Roozendaal, Ramon, Wuhrer, Manfred, and Vidarsson, Gestur

Published
2023
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3. Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Author

Van Coillie, Julie, primary, Pongracz, Tamas, additional, Šuštić, Tonći, additional, Wang, Wenjun, additional, Nouta, Jan, additional, Le Gars, Mathieu, additional, Keijzer, Sofie, additional, Linty, Federica, additional, Cristianawati, Olvi, additional, Keijser, Jim B.D., additional, Visser, Remco, additional, van Vught, Lonneke A., additional, Slim, Marleen A., additional, van Mourik, Niels, additional, Smit, Merel J., additional, Sander, Adam, additional, Schmidt, David E., additional, Steenhuis, Maurice, additional, Rispens, Theo, additional, Nielsen, Morten A., additional, Mordmüller, Benjamin G., additional, Vlaar, Alexander P.J., additional, Ellen van der Schoot, C., additional, Roozendaal, Ramon, additional, Wuhrer, Manfred, additional, Vidarsson, Gestur, additional, Appelman, Brent, additional, van de Beek, Diederik, additional, Bomers, Marije K., additional, de Brabander, Justin, additional, Brouwer, Matthijs C., additional, Buis, David T.P., additional, Chekrouni, Nora, additional, van Gils, Marit J., additional, de Jong, Menno D., additional, Lavell, Ayesha H.A., additional, Olie, Sabine E., additional, Peters, Edgar J.G., additional, Reijnders, Tom D.Y., additional, Schinkel, Michiel, additional, Schuurman, Alex R., additional, Sikkens, Jonne J., additional, Smulders, Yvo M., additional, Wiersinga, Joost W., additional, Spinello, Antinori, additional, Bassoli, Cinzia, additional, Bestetti, Giovanna, additional, Corbellino, Mario, additional, Covizzi, Alice, additional, Lupo, Angelica, additional, Milazzo, Laura, additional, Schiuma, Marco, additional, Torre, Alessandro, additional, de Jongh, Willem A., additional, Salanti, Ali, additional, Theander, Thor G., additional, McCall, Matthew B.B., additional, and Esen, Meral, additional

Published
2023
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4. Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Author

Van Coillie, Julie, Pongracz, Tamas, Šuštić, Tonći, Wang, Wenjun, Nouta, Jan, Le Gars, Mathieu, Keijzer, Sofie, Linty, Federica, Cristianawati, Olvi, Keijser, Jim B.D., Visser, Remco, van Vught, Lonneke A., Slim, Marleen A., van Mourik, Niels, Smit, Merel J., Sander, Adam, Schmidt, David E., Steenhuis, Maurice, Rispens, Theo, Nielsen, Morten A., Mordmüller, Benjamin G., Vlaar, Alexander P.J., Ellen van der Schoot, C., Roozendaal, Ramon, Wuhrer, Manfred, Vidarsson, Gestur, Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Smulders, Yvo M., Wiersinga, Joost W., Spinello, Antinori, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Salanti, Ali, Theander, Thor G., Van Coillie, Julie, Pongracz, Tamas, Šuštić, Tonći, Wang, Wenjun, Nouta, Jan, Le Gars, Mathieu, Keijzer, Sofie, Linty, Federica, Cristianawati, Olvi, Keijser, Jim B.D., Visser, Remco, van Vught, Lonneke A., Slim, Marleen A., van Mourik, Niels, Smit, Merel J., Sander, Adam, Schmidt, David E., Steenhuis, Maurice, Rispens, Theo, Nielsen, Morten A., Mordmüller, Benjamin G., Vlaar, Alexander P.J., Ellen van der Schoot, C., Roozendaal, Ramon, Wuhrer, Manfred, Vidarsson, Gestur, Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Smulders, Yvo M., Wiersinga, Joost W., Spinello, Antinori, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Salanti, Ali, and Theander, Thor G.

Published
2023

5. Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors : Results from Donor InSight

Author

Timmer, Tiffany C., de Groot, Rosa, Rijnhart, Judith J.M., Lakerveld, Jeroen, Brug, Johannes, Perenboom, Corine W.M., Baart, Mireille, Prinsze, Femmeke J., Zalpuri, Saurabh, Ellen van der Schoot, C., de Kort, Wim L.A.M., van den Hurk, Katja, Timmer, Tiffany C., de Groot, Rosa, Rijnhart, Judith J.M., Lakerveld, Jeroen, Brug, Johannes, Perenboom, Corine W.M., Baart, Mireille, Prinsze, Femmeke J., Zalpuri, Saurabh, Ellen van der Schoot, C., de Kort, Wim L.A.M., and van den Hurk, Katja

Published
2020

6. Sensitivity of fetalRHDscreening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the Netherlands

Author

de Haas, Masja, primary, Thurik, Florentine F, additional, van der Ploeg, Catharina P B, additional, Veldhuisen, Barbera, additional, Hirschberg, Hoang, additional, Soussan, Aicha Ait, additional, Woortmeijer, Heleen, additional, Abbink, Frithjofna, additional, Page-Christiaens, Godelieve C M L, additional, Scheffer, Peter G, additional, and Ellen van der Schoot, C, additional

Published
2016
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7. Early occurrence of red blood cell alloimmunization in patients with sickle cell disease

Author

Sins, Joep W.R., primary, Biemond, Bart J., additional, van den Bersselaar, Sil M., additional, Heijboer, H., additional, Rijneveld, Anita W., additional, Cnossen, Marjon H., additional, Kerkhoffs, Jean-Louis H., additional, van Meurs, Alfred H., additional, von Ronnen, F.B., additional, Zalpuri, Saurabh, additional, de Rijke, Yolanda B., additional, Ellen van der Schoot, C., additional, de Haas, Masja, additional, van der Bom, Johanna G., additional, and Fijnvandraat, Karin, additional

Published
2016
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8. Sensitivity of fetal RHDscreening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the Netherlands

Author

de Haas, Masja, Thurik, Florentine F, van der Ploeg, Catharina P B, Veldhuisen, Barbera, Hirschberg, Hoang, Soussan, Aicha Ait, Woortmeijer, Heleen, Abbink, Frithjofna, Page-Christiaens, Godelieve C M L, Scheffer, Peter G, and Ellen van der Schoot, C

Abstract

Objective To determine the accuracy of non-invasive fetal testing for the RHDgene in week 27 of pregnancy as part of an antenatal screening programme to restrict anti-D immunoglobulin use to women carrying a child positive for RHD.Design Prospectively monitoring of fetal RHDtesting accuracy compared with serological cord blood typing on introduction of the test. Fetal RHDtesting was performed with a duplex real time quantitative polymerase chain reaction, with cell-free fetal DNA isolated from 1 mL of maternal plasma The study period was between 4 July 2011 and 7 October 2012. The proportion of women participating in screening was determined.Setting Nationwide screening programme, the Netherlands. Tests are performed in a centralised setting.Participants 25 789 RhD negative pregnant women.Main outcome measures Sensitivity, specificity, false negative rate, and false positive rate of fetal RHDtesting compared with serological cord blood typing; proportion of technical failures; and compliance to the screening programme.Results A fetal RHDtest result and serological cord blood result were available for 25 789 pregnancies. Sensitivity for detection of fetal RHDwas 99.94% (95% confidence interval 99.89% to 99.97%) and specificity was 97.74% (97.43% to 98.02%). Nine false negative results for fetal RHDtesting were registered (0.03%, 95% confidence interval 0.01% to 0.06%). In two cases these were due to technical failures. False positive fetal RHDtesting results were registered for 225 samples (0.87%, 0.76% to 0.99%). Weak RhD expression was shown in 22 of these cases, justifying anti-D immunoglobulin use. The negative and positive predictive values were 99.91% (95% confidence interval 99.82% to 99.95%) and 98.60% (98.40% to 98.77%), respectively. More than 98% of the women participated in the screening programme.Conclusions Fetal RHDtesting in week 27 of pregnancy as part of a national antenatal screening programme is highly reliable and can be used to target both antenatal and postnatal anti-D immunoglobulin use.

Published
2016
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9. C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia.

Author

Kapur, Rick, Heitink-Pollé, Katja M. J., Porcelijn, Leendert, Bentlage, Arthur E. H., Bruin, Marrie C. A., Visser, Remco, Roos, Dirk, Schasfoort, Richard B. M., de Haas, Masja, Ellen van der Schoot, C., and Vidarsson, Gestur

Subjects
*THROMBOCYTOPENIA, *BLOOD platelet disorders, *IMMUNOGLOBULIN G, *IMMUNOGLOBULINS, *C-reactive protein
Abstract

Immune-mediated platelet destruction is most frequently caused by allo- or autoantibodies via Fcγ receptor-dependent phagocytosis. Disease severity can be predicted neither by antibody isotype nor by titer, indicating that other factors play a role. Here we show that the acute phase protein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by human phagocytes in vitro and in vivo in mice. Without antiplatelet antibodies, CRP was found to be inert toward platelets, but it bound to phosphorylcholine exposed after oxidation triggered by antiplatelet antibodies, thereby enhancing platelet phagocytosis. CRP levels were significantly elevated in patients with allo- and autoantibody-mediated thrombocytopenias compared with healthy controls. Within a week, intravenous immunoglobulin treatment in children with newly diagnosed immune thrombocytopenia led to significant decrease of CRP levels, increased platelet numbers, and clinically decreased bleeding severity. Furthermore, the higher the level of CRP at diagnosis, the longer it took before stable platelet counts were reached. These data suggest that CRP amplifies antibody-mediated platelet destruction and may in part explain the aggravation of thrombocytopenia on infections. Hence, targeting CRP could offer new therapeutic opportunities for these patients. [ABSTRACT FROM AUTHOR]

Published
2015
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10. Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity.

Author

Larsen MD, de Graaf EL, Sonneveld ME, Plomp HR, Nouta J, Hoepel W, Chen HJ, Linty F, Visser R, Brinkhaus M, Šuštić T, de Taeye SW, Bentlage AEH, Toivonen S, Koeleman CAM, Sainio S, Kootstra NA, Brouwer PJM, Geyer CE, Derksen NIL, Wolbink G, de Winther M, Sanders RW, van Gils MJ, de Bruin S, Vlaar APJ, Rispens T, den Dunnen J, Zaaijer HL, Wuhrer M, Ellen van der Schoot C, and Vidarsson G

Subjects
Adult, Aged, Antibodies, Viral blood, Antibodies, Viral chemistry, COVID-19 physiopathology, Cells, Cultured, Critical Illness, Cytomegalovirus immunology, Female, Fucose analysis, Glycosylation, HIV immunology, Hepatitis B Vaccines immunology, Humans, Immunoglobulin Fc Fragments chemistry, Immunoglobulin Fc Fragments immunology, Immunoglobulin G blood, Immunoglobulin G chemistry, Inflammation, Interleukin-6 biosynthesis, Interleukin-6 immunology, Macrophages immunology, Male, Middle Aged, Parvovirus B19, Human immunology, Severity of Illness Index, Spike Glycoprotein, Coronavirus immunology, Vaccines, Subunit immunology, Young Adult, Antibodies, Viral immunology, COVID-19 immunology, Immunoglobulin G immunology, SARS-CoV-2 immunology
Abstract

Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential for IgG function, shows variable composition in humans. Afucosylated IgG variants are already used in anticancer therapeutic antibodies for their increased activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated IgG (approximately 6% of total IgG in humans) are specifically formed against enveloped viruses but generally not against other antigens. This mediates stronger FcγRIIIa responses but also amplifies brewing cytokine storms and immune-mediated pathologies. Critically ill COVID-19 patients, but not those with mild symptoms, had high concentrations of afucosylated IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), amplifying proinflammatory cytokine release and acute phase responses. Thus, antibody glycosylation plays a critical role in immune responses to enveloped viruses, including COVID-19., (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

Published
2021
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