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Usage of MR imaging biomarkers is limited to experts. Automatic quantitative reports provide access for clinicians to data analysis. Automated data analysis was tested for usability in a small cohort of patients with hereditary spastic paraplegia type 4 (SPG4). We analyzed 3T MRI 3D-T1 datasets of n = 25 SPG4 patients and matched healthy controls using a commercial segmentation tool (AIRAscore structure 2.0.1) and standard VBM. In SPG4 total brain volume was reduced by 27.6 percentiles (p = 0.001) caused mainly by white matter loss (− 30.8th, p

Objective: Vessel wall contrast enhancement (VW-CE) has been shown to possibly predict disease progression in Moyamoya patients. Aim of this study was to investigate the predictive value of vessel wall contrast enhancement (CE) in Moyamoya Angiopathy (MMA) and its association with local disease progression [for full text, please go to the a.m. URL]

BackgroundWe hypothesized that ongoing IV thrombolysis (IVT) at flow restoration in patients with acute ischemic stroke (AIS) treated with IVT and endovascular thrombectomy (ET) is associated with improved outcome.MethodsWe included patients with IVT and successful recanalization (modified Thrombolysis in Cerebral Infarction score ≥2b) after ET from an observational multicenter cohort, the German Stroke Registry – Endovascular Treatment trial. Procedural characteristics and functional outcome at discharge and 90 days were compared between patients with and without ongoing IVT at flow restoration. To determine associations with functional outcome, adjusted ORs were calculated using ordinal multivariable logistic regression models adjusted for potential baseline confounder variables.ResultsAmong 1303 patients treated with IVT and ET who achieved successful recanalization, IVT was ongoing in 13.8% (n=180) at flow restoration. Ongoing IVT was associated with better functional outcome at discharge (adjusted OR 1.61; 95% CI 1.13 to 2.30) and at 90 days (adjusted OR 1.52; 95% CI 1.06 to 2.18).ConclusionThese results provide preliminary evidence for a benefit of ongoing IVT at flow restoration in patients with AIS treated with ET.

Objective: Vessel wall contrast enhancement has been shown to possibly predict disease progression in Moyamoya patients. Aim of this study is to investigate the natural course of vessel wall contrast enhancement in MMD and its association with local disease progression as seen in conventional angiography.[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: To evaluate chronological patterns of arterial wall contrast enhancement in high resolution MRI (CE-HR-MRI) of Moyamoya patients. Methods: A blinded analysis of clinical and imaging data was performed for Moyamoya patients with CE-HR-MRI. Data were analyzed chronologically for each patient[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Patients with Moyamoya Disease (MMD) need hemodynamic evaluation of vascular territories at risk of stroke. Today’s investigative standards include H215O PET/CT with pharmacological challenges with acetazolamide (ACZ). Recent developments suggest that CO2-triggered blood-oxygen-level-dependent[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: High-field iMRI suites provide surgeons with diagnostic-quality MR scans. However, more advanced imaging, such as DWI, is highly sensitive to susceptibility artefacts. We analyzed and defined the sources of interference, compared intraoperative and postoperative MR diffusion restrictions [for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Benign intracranial hypertension (BIH), traditionally termed pseudotumor cerebri, is a challenging disease complex with diverse etiologies. Because of improved MR venography sequences and interventional angiography techniques, the focus has shifted within the last decade to an appreciation[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Chronic benign intracranial hypertension may have a variety of causes. Most frequent is this syndrome found in obese young women ('pseudotumor cerebri'), still of unknown etiology. However, venous congestion due to sinus occlusion has to be ruled out. We report a young woman with an intrasinusal meningioma of the transverse sinus and hypoplasia of the transverse sinus contralaterally. Diagnosis was achieved by MRI and angiography. Imaging signs of increased intracranial pressure comprised dilated perioptic sheaths and an empty sella. Abnormalities of the brain parenchyma or the CSF spaces were absent.

Objective: Spinal cord herniation through a dural defect is a cause of myelopathy and may occur spontaneously, after surgery or trauma. The authors report on a series of 2 patients with spontaneous thoracic cord herniation with deteriorating neurological deficits and propose a surgical strategy. [for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Einleitung: Die Indikation zu einer invasiven Therapie vaskulärer Malformationen hängt nicht nur von der Beschwerdesymptomatik sondern auch von der Ausdehnung des Befundes ab. Ziel dieser Arbeit ist die Präsentation unserer Behandlungsstrategie und die Darstellung unserer Ergebnisse nach[for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Objective: The posterior circulation is often overlooked in moyamoya angiopathy. We present the clinical, neuroradiological findings and neurosurgical management of European moyamoya patients presenting with a stenosis/occlusion of the posterior cerebral artery (PCA). Method: Specific analysis[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)