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14 results on '"Espinosa Román, Laura"'

7. Case report: combined liver-kidney transplantation to correct a mutation in complement factor B in an atypical Hemolytic Uremic Syndrome patient

Author

Comunidad de Madrid, López-Trascasa, Margarita [0000-0001-8594-282X], Melgosa, Marta [0000-0001-6236-414X], Espinosa-Román, Laura [0000-0002-1668-3622], García-Fernández, Eugenia [0000-0002-3850-1906], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Sánchez-Corral, Pilar [0000-0003-4212-1233], López-Trascasa, Margarita, Alonso-Melgar, Ángel, Melgosa, Marta, Espinosa-Román, Laura, Lledín-Barbancho, María Dolores, García-Fernández, Eugenia, Rodríguez de Córdoba, Santiago, Sánchez-Corral, Pilar, Comunidad de Madrid, López-Trascasa, Margarita [0000-0001-8594-282X], Melgosa, Marta [0000-0001-6236-414X], Espinosa-Román, Laura [0000-0002-1668-3622], García-Fernández, Eugenia [0000-0002-3850-1906], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Sánchez-Corral, Pilar [0000-0003-4212-1233], López-Trascasa, Margarita, Alonso-Melgar, Ángel, Melgosa, Marta, Espinosa-Román, Laura, Lledín-Barbancho, María Dolores, García-Fernández, Eugenia, Rodríguez de Córdoba, Santiago, and Sánchez-Corral, Pilar

Abstract

Pathogenic gain-of-function variants in complement Factor B were identified as causative of atypical Hemolytic Uremic syndrome (aHUS) in 2007. These mutations generate a reduction on the plasma levels of complement C3. A four-month-old boy was diagnosed with hypocomplementemic aHUS in May 2000, and he suffered seven recurrences during the following three years. He developed a severe hypertension which required 6 anti-hypertensive drugs and presented acrocyanosis and several confusional episodes. Plasma infusion or exchange, and immunosuppressive treatments did not improve the clinical evolution, and the patient developed end-stage renal disease at the age of 3 years. Hypertension and vascular symptoms persisted while he was on peritoneal dialysis or hemodialysis, as well as after bilateral nephrectomy. C3 levels remained low, while C4 levels were normal. In 2005, a heterozygous gain-of-function mutation in Factor B (K323E) was found. A combined liver and kidney transplantation (CLKT) was performed in March 2009, since there was not any therapy for complement inhibition in these patients. Kidney and liver functions normalized in the first two weeks, and the C3/C4 ratio immediately after transplantation, indicating that the C3 activation has been corrected. After remaining stable for 4 years, the patient suffered a B-cell non-Hodgkin lymphoma that was cured by chemotherapy and reduction of immunosuppressive drugs. Signs of liver rejection with cholangitis were observed a few months later, and a second liver graft was done 11 years after the CLKT. One year later, the patient maintains normal kidney and liver functions, also C3 and C4 levels are within the normal range. The 12-year follow-up of the patient reveals that, in spite of severe complications, CLKT was an acceptable therapeutic option for this aHUS patient.

Published
2021

8. Diagnostic and therapeutic management of vesico-ureteral reflux in pediatric kidney transplantation-Results of an online survey on behalf of the European Society for Paediatric Nephrology

Author

Murer, Luisa, Knops, Noël, de Jong, Huib, Konrad, Martin, Levtchenko, Elena, Jankauskiene, Augustina, Madrid-Aris, Alvaro, Marks, Stephen D., Mattoo, Tej K., Maxted, Andrew, Jahnukainen, Timo, Hooman, Nakisa, Higueras, Walter, Goñi, Maria Herrero, Herthelius, Maria, Henne, Thomas, Grenda, Ryszard, Gessner, Michaela, Gander, Romy, Zirngibl, Matthias, Galiano, Matthias, Fila, Marc, Espinosa-Román, Laura, Esfandiar, Nasrin, Dinçel, Nida Temizkan, Kılıç, Beltinge Demircioğlu, Buder, Kathrin, Dehoux, Laurène, Cornelissen, Marlies, Clothier, Joanna, Cicek, Neslihan, Christian, Martin, Bulum, Burcu, Büscher, Anja, Melgosa-Hijosa, Marta, Luithle, Tobias, Tönshoff, Burkhard, Weitz, Marcus, Zieg, Jakub, Yüksel, Selçuk, Yıldız, Nurdan, Yap, Yok-Chin, Yalçınkaya, Fatma Fatoş, Weber, Lutz T., Mincham, Christine Marie, Alonso-Melgar, Ángel, Ariceta, Gema, Mitsioni, Andromachi, Montini, Giovanni, Awan, Atif, Morgan, Henry, Bakkaloglu, SEVCAN AZİME, Baskin, Esra, Vidal, Enrico, Bekassy, Zivile, Bhimma, Rajendra, Verrina, Enrico Eugenio, Bitzan, Martin, Aki, Fazil Tuncay, Tse, Yincent, Tschumi, Sibylle, Trnka, Peter, Bjerre, Anna Kristina, Torres, Diletta, Topaloğlu, Rezan, Bootsma-Robroeks, Charlotte M., Thumfart, Julia, Teixeira, Ana, Bouts, Antonia, Tasic, Velibor, Taşdemir, Mehmet, Stabouli, Stella, Sinha, Rajiv, Silva, Ana Cristina Simões E., Shenoy, Mohan, Seeman, Tomas, Rus, Rina, Rumyantsev, Alexander, Rubik, Jacek, Roussinov, Dimitar, Reynolds, Ben, Prytula, Agnieszka, Printza, Nikoleta, Parvex, Paloma, Pape, Lars, Özçakar, Z Birsin, Müller-Sacherer, Thomas, Pediatrics, Paediatric Nephrology, and ARD - Amsterdam Reproduction and Development

Subjects
Transplantation, therapy, vesico-ureteral reflux, Pediatrics, Perinatology and Child Health, online survey, febrile urinary tract infection, pediatric kidney transplantation, ureteral implantation
Abstract

© 2022 The Authors. Pediatric Transplantation published by Wiley Periodicals LLC.Background: Vesico-ureteral reflux (VUR) is considered to be a risk factor for recurrent febrile urinary tract infections and impaired renal transplant survival. Methods: An online survey supported by the European Society for Paediatric Nephrology was designed to evaluate current management strategies of VUR in native and transplanted kidneys of recipients aged

Published
2022
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9. Case Report: Combined Liver-Kidney Transplantation to Correct a Mutation in Complement Factor B in an Atypical Hemolytic Uremic Syndrome Patient

Author

López-Trascasa, Margarita, primary, Alonso-Melgar, Ángel, additional, Melgosa-Hijosa, Marta, additional, Espinosa-Román, Laura, additional, Lledín-Barbancho, María Dolores, additional, García-Fernández, Eugenia, additional, Rodríguez de Córdoba, Santiago, additional, and Sánchez-Corral, Pilar, additional

Published
2021
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11. Autores

Author

Alcobendas Rueda, Rosa, Alcolea Sánchez, Alida, Alonso García, Luis A., Alonso Melgar, Ángel, Alonso Prieto, Mercedes, Álvarez Román, M.ª Teresa, Aracil Santos, Francisco Javier, Ballesteros Moya, Estefanía, Baquero Artigao, Fernando, Barreda Bonis, Ana Coral, Barrio Gómez de Agüero, M.ª Isabel, Barrios Machiain, Ursino, Bote Gascón, Patricia, Bravo Feito, Juan, Bueno Barriocanal, Marta, Burgos Lucena, Laura, Bustamante Amador, Jorge, Cabello Blanco, Juan, Cabrera Lafuente, Marta, Calle Gómez, Ángeles, Calvo Rey, Cristina, Camarena Grande, Carmen, Carceller Benito, Fernando, Cartón Sánchez, Antonio, Castaño Andreu, Elisa, Climent Alcalá, Francisco J., Cuesta Rodríguez, Marian, De Andrés Baeza, Paloma, De Ceano-Vivas, María, De la Torre Ramos, Carlos, De Lucas García, Nieves, De Lucas Laguna, Raúl, Deiros-Bronte, Lucía, Del Castillo Martín, Fernando, Del Rosal Rabes, M.ª Teresa, Delgado Díez, Belén, Díaz Fernández, Carmen, Diz-Lois Palomares, Cristina, Dorado de Regil, Marta, Dorao Romillo, Paloma, Elorza Fernández, María Dolores, Escosa García, Luis, Espinosa Román, Laura, Estepa Fernández, Victoria, Fernández Camblor, Carlota, Ferrán Campillo, Luis, Ferreira Pou, Erika, Fiorita, Filippo, Fuentes Gimeno, Blanca, García-Arenzana, Nicolás, García Ascaso, Marta, García Fernández-Villalta, Marta, García García, Santos, García Guereta, Luis, García Guixot, Sara, García Lasheras, Cristina, García López-Hortelano, Milagros, García-Mauriño, Cristina, García Meseguer, Carmen, García Nardiz, Cristina, García Sánchez, Paula, Goded Rimbaud, Federico, Gómez Zamora, Ana, González Benítez, Cristina, González Bertolín, Isabel, González Casado, Isabel, González Hernando, María Luisa, González Morán, Gaspar, González Sacristán, Rocío, Goycochea Valdivia, Walter A., Guerrero Fernández, Julio, Hernández Gutiérrez, Alicia, Hernández Palomo, Rosa, Herrera Castillo, Laura, Itza Martín, Nerea, Jara Vega, Paloma, Jiménez Yuste, Víctor, Laita de Roda, Paula, Laura Fernández, Ana, Lázaro de Lucas, Carmen, López Carrasco, Ana, López López, M.ª del Rosario, López Ortego, Paloma, López Pereira, Pedro, María Eugenia, Martín Maldonado, Martín Sánchez, Julia, Martínez Bermejo, Antonio, Martínez Martínez, Leopoldo, Martínez-Ojínaga, Eva, Martínez Urrutia, M.ª José, Melgosa Hijosa, Marta, Mellado Peña, M.ª José, Méndez Echevarría, Ana, Menéndez Suso, Juan J., Molina Gutiérrez, Miguel Á., Montejano Milner, Rafael, Mora Palma, Cristina, MorÁis López, Ana, Moraleda Cobo, Luis, Moreno Sánchez, Francisco J., Moreno Sanz-Gadea, Bárbara, Muñoz Bartolo, Gema, Muñoz Muñiz, M.ª del Mar, Murcia Zorita, Francisco Javier, Murias Loza, Sara, Nebreda Pérez, Verónica, Noci Belda, Jesús, Núñez Cerezo, Vanesa, Ots Ruiz, Cristina, Peña Carrión, Antonia, Peralta Calvo, Jesús, Pérez Mora, Rosa María, Plaza López de Sabando, Diego, Reinoso Barbero, Francisco, Remesal Camba, Agustín, Reyero Farreras, Andrea, Robustillo Rodela, Ana, Romero Amor, Elena, Rubio Aparicio, Pedro, Rubio Sánchez-Tirado, Mercedes, Ruiz Domínguez, José A., Saceda Gutiérrez, Javier M., Sáinz Costa, Talía, Salamanca Fresno, Luis, Salas Bolívar, Patricia, Salcedo Montejo, María, Salmerón Ruiz, María, Sánchez Galán, Alba, Sanromán Pacheco, Sonsoles, Santos Simarro, Guillermo, Sanz González, Paloma, Sarría Oses, Jesús, Sastre Urgelles, Ana, Schüffelmann Gutiérrez, Cristina, Tirado Requero, Pilar, Torres Deulofeu, Clara, Udaondo Gascón, Clara, Vacas del Arco, Beatriz, Valverde Núñez, Eva, Vara Izquierdo, Teresa, Vega Benito Sánchez, Andrea, Velázquez Fragua, Ramón, Verdú Sánchez, Cristina, Yan Tong, Hoi, and Zarauza Santoveña, Alejandro

Published
2020
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12. Case Report: Combined Liver-Kidney Transplantation to Correct a Mutation in Complement Factor B in an Atypical Hemolytic Uremic Syndrome Patient

Author

Margarita López-Trascasa, Ángel Alonso-Melgar, Marta Melgosa-Hijosa, Laura Espinosa-Román, María Dolores Lledín-Barbancho, Eugenia García-Fernández, Santiago Rodríguez de Córdoba, Pilar Sánchez-Corral, Comunidad de Madrid, López-Trascasa, Margarita [0000-0001-8594-282X], Melgosa, Marta [0000-0001-6236-414X], Espinosa-Román, Laura [0000-0002-1668-3622], García-Fernández, Eugenia [0000-0002-3850-1906], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Sánchez-Corral, Pilar [0000-0003-4212-1233], López-Trascasa, Margarita, Melgosa, Marta, Espinosa-Román, Laura, García-Fernández, Eugenia, Rodríguez de Córdoba, Santiago, and Sánchez-Corral, Pilar

Subjects
medicine.medical_specialty, medicine.medical_treatment, Immunology, Complement, Case Report, Complement factor B, Gastroenterology, Peritoneal dialysis, combined liver-kidney transplantation, Internal medicine, Atypical hemolytic uremic syndrome, factor B, medicine, Immunology and Allergy, complement, Factor B, Atypical Hemolytic Uremic Syndrome, Combined liver-kidney transplantation, Kidney, Chemotherapy, Acrocyanosis, business.industry, atypical hemolytic uremic syndrome, rare diseases, RC581-607, medicine.disease, Rare diseases, Transplantation, medicine.anatomical_structure, Hemodialysis, Immunologic diseases. Allergy, business
Abstract

Pathogenic gain-of-function variants in complement Factor B were identified as causative of atypical Hemolytic Uremic syndrome (aHUS) in 2007. These mutations generate a reduction on the plasma levels of complement C3. A four-month-old boy was diagnosed with hypocomplementemic aHUS in May 2000, and he suffered seven recurrences during the following three years. He developed a severe hypertension which required 6 anti-hypertensive drugs and presented acrocyanosis and several confusional episodes. Plasma infusion or exchange, and immunosuppressive treatments did not improve the clinical evolution, and the patient developed end-stage renal disease at the age of 3 years. Hypertension and vascular symptoms persisted while he was on peritoneal dialysis or hemodialysis, as well as after bilateral nephrectomy. C3 levels remained low, while C4 levels were normal. In 2005, a heterozygous gain-of-function mutation in Factor B (K323E) was found. A combined liver and kidney transplantation (CLKT) was performed in March 2009, since there was not any therapy for complement inhibition in these patients. Kidney and liver functions normalized in the first two weeks, and the C3/C4 ratio immediately after transplantation, indicating that the C3 activation has been corrected. After remaining stable for 4 years, the patient suffered a B-cell non-Hodgkin lymphoma that was cured by chemotherapy and reduction of immunosuppressive drugs. Signs of liver rejection with cholangitis were observed a few months later, and a second liver graft was done 11 years after the CLKT. One year later, the patient maintains normal kidney and liver functions, also C3 and C4 levels are within the normal range. The 12-year follow-up of the patient reveals that, in spite of severe complications, CLKT was an acceptable therapeutic option for this aHUS patient., ML-T, SRC, and PS-C are supported by the Spanish Autonomous Region of Madrid (Complement II-CM network; B2017/BMD-3673).

Published
2021

13. Salud oral en el niño trasplantado renal

Author

Martín Muñoz, Fátima, Nova García, Manuel Joaquín, Espinosa Román, Laura, and Albajara Velasco, Luis

Subjects
Odontología infantil
Published
2016

14. Distar Renal Tubular Acidosis (dRTA): Epidemiological, diagnostics, clinical follow-up and therapeutical issues. Nephrologists cohort survey outcome.

Author

Torregrosa Prats JV, Santos Rodríguez F, González Parra E, Espinosa Román L, Buades Fuster JM, Monteagud-Marrahí E, and Navas Serrano VM

Abstract

Background and Objectives: dRTA is a genetic or acquired rare disease, characterized by an unability to excrete hydrogens (H+) into urine, hypobicarbonatemia, hyperchloremia, and frequently hypercalciuria and hypokalaemia. Genetic forms are usually diagnosed during the first months of life and its treatment is based on providing alkali supplements in order to prevent long term clinical consequences, particularly chronic kidney disease (described in some cohorts up to 82% of dRTA patients) and the associated bone disease. A 10 queries multi choice closed response survey was designed to know more about epidemiological, diagnostics, clinical management and therapeutical issues of this disease among Spanish nephrologists., Materials and Methods: This survey was delivered to the attendees to a scientific meeting on dRTA at the Spanish Nephrology Society congress in 2019. Surveys were collected at the end of this dRTA event. Results were analyzed by using a parametric statistical test, obtaining the percentage of each response for the 10 questions., Results: Among the survey responders, 44.4% and 37.7% did not visit any dRTA patient during the 1st and 3rd last year respectively. When having a suspicious diagnose, confirming genetic diagnostic test is only performed on the 13.3% of cases and pedigree studies only on 11.1%. Only a 26.6% confirms that metabolic control is excellent, good or very good, and 69% of the responders believe that treatment compliance is not bad, bad or very bad., Conclusions: This survey enhances the fact that dRTA is not a well known entity, satisfaction with metabolic control is poor and compliance is low. All these factors can lead to a higher severity of renal and bone diseases associated to dRTA., (Copyright © 2020 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.)

Published
2021
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