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4. Management of acute appendicitis during COVID-19 pandemic. Single center data from a tertiary care hospital in Germany

Author

Andric Mihailo, Stockheim Jessica, Rahimli Mirhasan, Klös Michael, Esser Torben, Soldatovic Ivan, Dölling Maximilian, Al-Madhi Sara, Acciuffi Sara, Croner Roland, and Perrakis Aristotelis

Subjects
acute appendicitis, appendicectomy, conservative treatment, covid-19, Surgery, RD1-811
Abstract

The unexpected global overload of the health system during COVID-19 pandemic has caused changes in management of acute appendicitis worldwide. Whereas conservative treatment was widely recommended, the appendicectomy remained standard therapy in Germany. We aimed to investigate the impact of COVID-19 pandemic on treatment routine for acute appendicitis at University Hospital of Magdeburg.

Published
2023
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7. EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

Author

Kaufmann, Marc, Thaler, Markus, Maier, Martin, Prause, Gerhard, Trimmel, Helmut, de Longueville, Diane, Preseau, Thierry, Biarent, Dominique, Melot, Christian, Mpotos, Nicolas, Monsieurs, Koen, Van de Voorde, Patrick, Vanhove, Marie, Lievens, Pascale, Faniel, Mathias, Keleuva, Slobodanka, Lazarevic, Milan, Ujevic, Radmila Majhen, Devcic, Mato, Bardak, Branka, Barisic, Fabijan, Anticevic, Silvija Hunyadi, Georgiou, Marios, Truhláſ, Anatolij, Knor, Jiſí, Smržová, Eva, Sviták, Roman, Šín, Robin, Mokrejš, Petr, Lippert, Freddy K., Hallikainen, Juhana, Hoikka, Marko, Iirola, Timo, Jama, Timo, Jäntti, Helena, Jokisalo, Raimo, Jousi, Milla, Kirves, Hetti, Kuisma, Markku, Laine, Jukka, Länkimäki, Sami, Loikas, Petri, Lund, Vesa, Määttä, Teuvo, Nal, Heini, Niemelä, Heimo, Portaankorva, Petra, Pylkkänen, Marko, Sainio, Marko, Setälä, Piritta, Tervo, Jerry, Väyrynen, Taneli, Murgue, Davy, Champenois, Anne, Fournier, Marc, Meyran, Daniel, Tabary, Romain, Avondo, Aurélie, Gelin, Gelin, Simonnet, Bruno, Joly, Marc, Megy-Michoux, Isabelle, Paringaux, Xavier, Duffait, Yves, Vial, Michael, Segard, Julien, Narcisse, Sophie, Hamban, David, Hennache, Jonathan, Thiriez, Sylvain, Doukhan, Mathieu, Vanderstraeten, Carine, Morel, Jean-Charles, Majour, Gilles, Michenet, Corinne, Tritsch, Laurent, Dubesset, Marc, Peguet, Olivier, Pinero, David, Guillaumee, Fréderic, Fuster, Patrick, Ciacala, Jean-François, Jardel, Benoît, Letarnec, Jean-Yves, Goes, Frank, Gosset, Pierre, Vergne, Muriel, Bar, Christian, Branche, Fabienne, Prineau, Stevens, Lagadec, Steven, Cornaglia, Carole, Ursat, Cécile, Bertrand, Philippe, Agostinucci, Jean-Marc, Nadiras, Pierre, de Linares, Géraldine Gonzales, Jacob, Line, Revaux, François, Pernot, Thomas, Roudiak, Nathalie, Ricard-Hibon, Agnès, Villain-Coquet, Laurent, Beckers, Stefan, Hanff, Thomas, Strickmann, Bernd, Wiegand, Nicolai, Wilke, Petra, Sues, Harald, Bogatzki, Stefan, Baumeier, Wolfgang, Pohl, Kai, Werner, Bert, Fischer, Hans, Zeng, Torsten, Popp, Erik, Günther, Andreas, Hochberg, Andreas, Lechleuthner, Alex, Schewe, Jens-Christian, Lemke, Hans, Wranze-Bielefeld, Erich, Bohn, Andreas, Roessler, Markus, Naujoks, Frank, Sensen, Frank, Esser, Torben, Fischer, Matthias, Messelken, Martin, Rose, Christopher, Schlüter, Gabriele, Lotz, Wolfgang, Corzilius, Michael, Muth, Claus-Martin, Diepenseifen, Christian, Tauchmann, Björn, Birkholz, Torsten, Flemming, Andreas, Herrmann, Stefanie, Kreimeier, Uwe, Kill, Clemens, Marx, Frank, Schröder, Ralph, Lenz, Wolfgang, Botini, Glykeria, Grigorios, Barakos, Giannakoudakis, Nikolaos, Zervopoulos, Michail, Papangelis, Dimitrios, Petropoulou-Papanastasiou, Sofia, Liaskos, Themistoklis, Papanikolaou, Spyridon, Karabinis, Andreas, Zentay, Attila, ÿorsteinsson, Hólmgeir, Gilsdóttir, Anna, Birgisson, Svavar A., Guðmundsson, Fjölnir Freyr, Hreiðarsson, Hallgrímur, ÿrnason, Björgvin, Hermannsson, Hermann, Björnsson, Gísli, Friðriksson, Brynjar ÿór, Baldursson, Gunnar, Höskuldsson, ÿrmann, Valgarðsdottir, Jórunn, ÿsmundardóttir, Matthildur, Guðmundsson, Guðmundur, Kristjánsson, Hjörtur, ÿórarinsson, Eyþór Rúnar, Guðlaugsson, Jón, Skarphéðinsson, Sigurður, Peratoner, Alberto, Santarelli, Andrea, Sabetta, Cesare, Gordini, Giovanni, Sesana, Giovanni, Giudici, Riccardo, Savastano, Simone, Pellis, Tommaso, Beissel, Jean, Uhrig, Jean, Manderscheid, Tom, Klop, Marco, Stammet, Pascal, Koch, Marc, Welter, Philippe, Schuman, Robert, Bruins, Wendy, Amin, Hesam, Braa, Nina, Bratland, Staale, Buanes, Eirik Alnes, Draegni, Tomas, Johnsen, Knut Roar, Mathisen, Wenche Torunn, Oedegaarden, Terje, Oppedal, Marie, Reksten, Alf Stolt-Nielsen, Roedsand, Mats Eirik, Steen-Hansen, Jon Erik, Dyrda, Marta, Frejlich, Anna, MaciĿg, Sſawomir, Osadnik, Sonia, Weryk, Ireneusz, Mendonça, Eugénio, Freitas, Carlos, Cruz, Pinto, Caldeira, Carmo, Barros, José, Vale, Luis, Brazão, António, Jardim, Nuno, Rocha, Fernanda, Duarte, Ricardo, Fernandes, Nicodemos, Ramos, Pedro, Jardim, Margarida, Reis, Miguel, Ribeiro, Romulo, Zenha, Sérgio, Fernandes, Jorge, Francisco, Juan, Assis, David, Abreu, Fernanda, Freitas, Dinarte, Ribeiro, Leonardo, Azevedo, Paulo, Calafatinho, Débora, Jardim, Rui, Pestana, Aleixo, Faria, Rui, Oprita, Bogdan, Grasu, Alis, Nedelea, Paul, Sovar, Sorina, Agapi, Florin, KliĿkoviĿ, Aleksandar, LaziĿ, Aleksandra, NikoliĿ, Bogdan, Zivanovic, Bogdan, MartinoviĿ, Branislav, MilenkoviĿ, Dušan, Damir, HuseinoviĿ, Koprivica, Jovanka, JakšiĿ, Kornelija Horvat, Pajor, Margit, MiliĿ, Saša, VidoviĿ, Mirko, Glamoclija, Radojka Petrovic, Andjelic, Sladjana, Sladjana, Vlajovic, BabiĿ, Zlatko, Fišer, Zlatko, Androvic, Peter, Bajerovska, Lubica, Chabron, Miroslav, Dobias, Viliam, Havlikova, Eva, Horanova, Bozena, Kratochvilova, Renata, Kubova, Dana, Murgas, Jan, Patras, Juraj, Simak, Ladislav, Snarskij, Vladimir, Zaviaticova, Zuzana, Zuffova, Marcela, Roig, Francesc Escalada, Santos, Luis Sánchez, Sucunza, Alfredo Echarri, Cordero Torres, Juan A., Muñoz, Guadalupe Inza, del Valle, Marta Martínez, Rozalen, Isabel Ceniceros, Sánchez, Enrique Martín, Berlanga, María Victoria Raúl Canabal, Olalde, Karlos Ibarguren, Ruiz Azpiazu, José I., García-Ochoa, María José, López-Navarro, Rafael Zoyo, Adsuar Quesada, José M., Cortés Ramas, José A., Mellado Vergel, Francisco J., López Messa, Juan B., del Valle, Patricia Fernández, Anselmi, Luciano, Benvenuti, Breganzona Claudio, Batey, Nigel, Ambulance, Yorkshire, Booth, Scott, Bucher, Patricia, Deakin, Charles D., Duckett, Jay, Ji, Chen, Loughlin, Nancy, Lumley-Holmes, Jenny, Lynde, Jessica, Mersom, Frank, Ramsey, Carly, Robinson, Clare, Spaight, Robert, Dosanjh, Sukhdeep, Virdi, Gurkamal, Whittington, Andrew, Gräsner, Jan-Thorsten, Lefering, Rolf, Koster, Rudolph W., Masterson, Siobhán, Böttiger, Bernd W., Herlitz, Johan, Wnent, Jan, Tjelmeland, Ingvild B.M., Ortiz, Fernando Rosell, Maurer, Holger, Baubin, Michael, Mols, Pierre, HadžibegoviĿ, Irzal, Ioannides, Marios, Škulec, Roman, Wissenberg, Mads, Salo, Ari, Hubert, Hervé, Nikolaou, Nikolaos I., Lóczi, Gerda, Svavarsdóttir, Hildigunnur, Semeraro, Federico, Wright, Peter J., Clarens, Carlo, Pijls, Ruud, Cebula, Grzegorz, Correia, Vitor Gouveia, Cimpoesu, Diana, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Strömsöe, Anneli, Burkart, Roman, Perkins, Gavin D., and Bossaert, Leo L.

Published
2016
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14. EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry

Author

Gräsner, Jan-Thorsten, primary, Lefering, Rolf, additional, Koster, Rudolph W., additional, Masterson, Siobhán, additional, Böttiger, Bernd W., additional, Herlitz, Johan, additional, Wnent, Jan, additional, Tjelmeland, Ingvild B.M., additional, Ortiz, Fernando Rosell, additional, Maurer, Holger, additional, Baubin, Michael, additional, Mols, Pierre, additional, HadžibegoviĿ, Irzal, additional, Ioannides, Marios, additional, Škulec, Roman, additional, Wissenberg, Mads, additional, Salo, Ari, additional, Hubert, Hervé, additional, Nikolaou, Nikolaos I., additional, Lóczi, Gerda, additional, Svavarsdóttir, Hildigunnur, additional, Semeraro, Federico, additional, Wright, Peter J., additional, Clarens, Carlo, additional, Pijls, Ruud, additional, Cebula, Grzegorz, additional, Correia, Vitor Gouveia, additional, Cimpoesu, Diana, additional, Raffay, Violetta, additional, Trenkler, Stefan, additional, Markota, Andrej, additional, Strömsöe, Anneli, additional, Burkart, Roman, additional, Perkins, Gavin D., additional, Bossaert, Leo L., additional, Kaufmann, Marc, additional, Thaler, Markus, additional, Maier, Martin, additional, Prause, Gerhard, additional, Trimmel, Helmut, additional, de Longueville, Diane, additional, Preseau, Thierry, additional, Biarent, Dominique, additional, Melot, Christian, additional, Mpotos, Nicolas, additional, Monsieurs, Koen, additional, Van de Voorde, Patrick, additional, Vanhove, Marie, additional, Lievens, Pascale, additional, Faniel, Mathias, additional, Keleuva, Slobodanka, additional, Lazarevic, Milan, additional, Ujevic, Radmila Majhen, additional, Devcic, Mato, additional, Bardak, Branka, additional, Barisic, Fabijan, additional, Anticevic, Silvija Hunyadi, additional, Georgiou, Marios, additional, Truhláſ, Anatolij, additional, Knor, Jiſí, additional, Smržová, Eva, additional, Sviták, Roman, additional, Šín, Robin, additional, Mokrejš, Petr, additional, Lippert, Freddy K., additional, Hallikainen, Juhana, additional, Hoikka, Marko, additional, Iirola, Timo, additional, Jama, Timo, additional, Jäntti, Helena, additional, Jokisalo, Raimo, additional, Jousi, Milla, additional, Kirves, Hetti, additional, Kuisma, Markku, additional, Laine, Jukka, additional, Länkimäki, Sami, additional, Loikas, Petri, additional, Lund, Vesa, additional, Määttä, Teuvo, additional, Nal, Heini, additional, Niemelä, Heimo, additional, Portaankorva, Petra, additional, Pylkkänen, Marko, additional, Sainio, Marko, additional, Setälä, Piritta, additional, Tervo, Jerry, additional, Väyrynen, Taneli, additional, Murgue, Davy, additional, Champenois, Anne, additional, Fournier, Marc, additional, Meyran, Daniel, additional, Tabary, Romain, additional, Avondo, Aurélie, additional, Gelin, Gelin, additional, Simonnet, Bruno, additional, Joly, Marc, additional, Megy-Michoux, Isabelle, additional, Paringaux, Xavier, additional, Duffait, Yves, additional, Vial, Michael, additional, Segard, Julien, additional, Narcisse, Sophie, additional, Hamban, David, additional, Hennache, Jonathan, additional, Thiriez, Sylvain, additional, Doukhan, Mathieu, additional, Vanderstraeten, Carine, additional, Morel, Jean-Charles, additional, Majour, Gilles, additional, Michenet, Corinne, additional, Tritsch, Laurent, additional, Dubesset, Marc, additional, Peguet, Olivier, additional, Pinero, David, additional, Guillaumee, Fréderic, additional, Fuster, Patrick, additional, Ciacala, Jean-François, additional, Jardel, Benoît, additional, Letarnec, Jean-Yves, additional, Goes, Frank, additional, Gosset, Pierre, additional, Vergne, Muriel, additional, Bar, Christian, additional, Branche, Fabienne, additional, Prineau, Stevens, additional, Lagadec, Steven, additional, Cornaglia, Carole, additional, Ursat, Cécile, additional, Bertrand, Philippe, additional, Agostinucci, Jean-Marc, additional, Nadiras, Pierre, additional, de Linares, Géraldine Gonzales, additional, Jacob, Line, additional, Revaux, François, additional, Pernot, Thomas, additional, Roudiak, Nathalie, additional, Ricard-Hibon, Agnès, additional, Villain-Coquet, Laurent, additional, Beckers, Stefan, additional, Hanff, Thomas, additional, Strickmann, Bernd, additional, Wiegand, Nicolai, additional, Wilke, Petra, additional, Sues, Harald, additional, Bogatzki, Stefan, additional, Baumeier, Wolfgang, additional, Pohl, Kai, additional, Werner, Bert, additional, Fischer, Hans, additional, Zeng, Torsten, additional, Popp, Erik, additional, Günther, Andreas, additional, Hochberg, Andreas, additional, Lechleuthner, Alex, additional, Schewe, Jens-Christian, additional, Lemke, Hans, additional, Wranze-Bielefeld, Erich, additional, Bohn, Andreas, additional, Roessler, Markus, additional, Naujoks, Frank, additional, Sensen, Frank, additional, Esser, Torben, additional, Fischer, Matthias, additional, Messelken, Martin, additional, Rose, Christopher, additional, Schlüter, Gabriele, additional, Lotz, Wolfgang, additional, Corzilius, Michael, additional, Muth, Claus-Martin, additional, Diepenseifen, Christian, additional, Tauchmann, Björn, additional, Birkholz, Torsten, additional, Flemming, Andreas, additional, Herrmann, Stefanie, additional, Kreimeier, Uwe, additional, Kill, Clemens, additional, Marx, Frank, additional, Schröder, Ralph, additional, Lenz, Wolfgang, additional, Botini, Glykeria, additional, Grigorios, Barakos, additional, Giannakoudakis, Nikolaos, additional, Zervopoulos, Michail, additional, Papangelis, Dimitrios, additional, Petropoulou-Papanastasiou, Sofia, additional, Liaskos, Themistoklis, additional, Papanikolaou, Spyridon, additional, Karabinis, Andreas, additional, Zentay, Attila, additional, ÿorsteinsson, Hólmgeir, additional, Gilsdóttir, Anna, additional, Birgisson, Svavar A., additional, Guðmundsson, Fjölnir Freyr, additional, Hreiðarsson, Hallgrímur, additional, ÿrnason, Björgvin, additional, Hermannsson, Hermann, additional, Björnsson, Gísli, additional, Friðriksson, Brynjar ÿór, additional, Baldursson, Gunnar, additional, Höskuldsson, ÿrmann, additional, Valgarðsdottir, Jórunn, additional, ÿsmundardóttir, Matthildur, additional, Guðmundsson, Guðmundur, additional, Kristjánsson, Hjörtur, additional, ÿórarinsson, Eyþór Rúnar, additional, Guðlaugsson, Jón, additional, Skarphéðinsson, Sigurður, additional, Peratoner, Alberto, additional, Santarelli, Andrea, additional, Sabetta, Cesare, additional, Gordini, Giovanni, additional, Sesana, Giovanni, additional, Giudici, Riccardo, additional, Savastano, Simone, additional, Pellis, Tommaso, additional, Beissel, Jean, additional, Uhrig, Jean, additional, Manderscheid, Tom, additional, Klop, Marco, additional, Stammet, Pascal, additional, Koch, Marc, additional, Welter, Philippe, additional, Schuman, Robert, additional, Bruins, Wendy, additional, Amin, Hesam, additional, Braa, Nina, additional, Bratland, Staale, additional, Buanes, Eirik Alnes, additional, Draegni, Tomas, additional, Johnsen, Knut Roar, additional, Mathisen, Wenche Torunn, additional, Oedegaarden, Terje, additional, Oppedal, Marie, additional, Reksten, Alf Stolt-Nielsen, additional, Roedsand, Mats Eirik, additional, Steen-Hansen, Jon Erik, additional, Dyrda, Marta, additional, Frejlich, Anna, additional, MaciĿg, Sſawomir, additional, Osadnik, Sonia, additional, Weryk, Ireneusz, additional, Mendonça, Eugénio, additional, Freitas, Carlos, additional, Cruz, Pinto, additional, Caldeira, Carmo, additional, Barros, José, additional, Vale, Luis, additional, Brazão, António, additional, Jardim, Nuno, additional, Rocha, Fernanda, additional, Duarte, Ricardo, additional, Fernandes, Nicodemos, additional, Ramos, Pedro, additional, Jardim, Margarida, additional, Reis, Miguel, additional, Ribeiro, Romulo, additional, Zenha, Sérgio, additional, Fernandes, Jorge, additional, Francisco, Juan, additional, Assis, David, additional, Abreu, Fernanda, additional, Freitas, Dinarte, additional, Ribeiro, Leonardo, additional, Azevedo, Paulo, additional, Calafatinho, Débora, additional, Jardim, Rui, additional, Pestana, Aleixo, additional, Faria, Rui, additional, Oprita, Bogdan, additional, Grasu, Alis, additional, Nedelea, Paul, additional, Sovar, Sorina, additional, Agapi, Florin, additional, KliĿkoviĿ, Aleksandar, additional, LaziĿ, Aleksandra, additional, NikoliĿ, Bogdan, additional, Zivanovic, Bogdan, additional, MartinoviĿ, Branislav, additional, MilenkoviĿ, Dušan, additional, Damir, HuseinoviĿ, additional, Koprivica, Jovanka, additional, JakšiĿ, Kornelija Horvat, additional, Pajor, Margit, additional, MiliĿ, Saša, additional, VidoviĿ, Mirko, additional, Glamoclija, Radojka Petrovic, additional, Andjelic, Sladjana, additional, Sladjana, Vlajovic, additional, BabiĿ, Zlatko, additional, Fišer, Zlatko, additional, Androvic, Peter, additional, Bajerovska, Lubica, additional, Chabron, Miroslav, additional, Dobias, Viliam, additional, Havlikova, Eva, additional, Horanova, Bozena, additional, Kratochvilova, Renata, additional, Kubova, Dana, additional, Murgas, Jan, additional, Patras, Juraj, additional, Simak, Ladislav, additional, Snarskij, Vladimir, additional, Zaviaticova, Zuzana, additional, Zuffova, Marcela, additional, Roig, Francesc Escalada, additional, Santos, Luis Sánchez, additional, Sucunza, Alfredo Echarri, additional, Cordero Torres, Juan A., additional, Muñoz, Guadalupe Inza, additional, del Valle, Marta Martínez, additional, Rozalen, Isabel Ceniceros, additional, Sánchez, Enrique Martín, additional, Berlanga, María Victoria Raúl Canabal, additional, Olalde, Karlos Ibarguren, additional, Ruiz Azpiazu, José I., additional, García-Ochoa, María José, additional, López-Navarro, Rafael Zoyo, additional, Adsuar Quesada, José M., additional, Cortés Ramas, José A., additional, Mellado Vergel, Francisco J., additional, López Messa, Juan B., additional, del Valle, Patricia Fernández, additional, Anselmi, Luciano, additional, Benvenuti, Breganzona Claudio, additional, Batey, Nigel, additional, Ambulance, Yorkshire, additional, Booth, Scott, additional, Bucher, Patricia, additional, Deakin, Charles D., additional, Duckett, Jay, additional, Ji, Chen, additional, Loughlin, Nancy, additional, Lumley-Holmes, Jenny, additional, Lynde, Jessica, additional, Mersom, Frank, additional, Ramsey, Carly, additional, Robinson, Clare, additional, Spaight, Robert, additional, Dosanjh, Sukhdeep, additional, Virdi, Gurkamal, additional, and Whittington, Andrew, additional

Published
2016
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15. Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation.

Author

KEILHOFF, GERBURG, TITZE, MAXIMILIAN, ESSER, TORBEN, EBMEYER, UWE, and SCHILD, LORENZ

Subjects
GYNOSTEMMA pentaphyllum, NEUROPROTECTIVE agents, CARDIOPULMONARY resuscitation, CARDIAC arrest, ISCHEMIA
Abstract

Asphyxial cardiac arrest (ACA)-induced ischemia results in acute and delayed neuronal cell death. The early reperfusion phase is critical for the outcome. Intervention strategies directed to this period are promising to reduce ACA/resuscitation-dependent impairments. This study focused on the evaluation of the protective potential of an extract from Gynostemma pentaphyllum (GP), a plant used in traditional medicine with antioxidative, glucose lowering and neuroprotective activities, in an ACA rat model. We tested the following parameters: i) Basic systemic parameters such as pCO2 and blood glucose value within the first 30 min post-ACA; ii) mitochondrial response by determining activities of citrate synthase, respiratory chain complexes I + III and II + III, and the composition of cardiolipin 6 and 24 h post-ACA; iii) neuronal vitality of the CA1 hippocampal region by immunohistochemistry 24 h and 7 days post-ACA; and iv) cognitive function by a novel object recognition test 7 days post-ACA. GP, administered after reaching spontaneous circulation, counteracted the following: i) ACA-mediated increases in arterial CO2 tension and blood glucose values; ii) transient increase in the activity of the respiratory chain complexes II + III; iii) elevation in cardiolipin content; iv) hippocampal CA1 neurodegeneration, and v) loss of normal novelty-object seeking. The protective effects of GP were accompanied by side effects of the vehicle DMSO, such as the stimulation of citrate synthase activity in control animals, inhibition of cardiolipin synthesis in ACA animals and complex II + III activity in both control and ACA animals. The results emphasize the importance of the early post-resuscitation phase for the neurological outcome after ACA/resuscitation, and demonstrated the power of GP substitution as neuroprotective intervention. Moreover, the results underline the need of a careful handling of the popular vehicle DMSO. [ABSTRACT FROM AUTHOR]

Published
2017
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