Search

Your search keyword '"FORTI, GIANNI"' showing total 162 results
Start Over Author "FORTI, GIANNI" Publication Year Range Last 10 years
162 results on '"FORTI, GIANNI"'

1. Late-Onset Hypogonadism

Author

Rastrelli, Giulia, Forti, Gianni, Lenzi, Andrea, Series editor, Jannini, Emmanuele A., Series editor, Simoni, Manuela, editor, and Huhtaniemi, Ilpo T., editor

Published
2017
Full Text
View/download PDF

2. Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study

Author

Overman, Margot J., Pendleton, Neil, O'Neill, Terence W., Bartfai, Gyorgy, Casanueva, Felipe F., Forti, Gianni, Rastrelli, Giulia, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E.J., Punab, Margus, Lee, David M., Correa, Elon S., Ahern, Tomas, Laurent, Michaël R., Verschueren, Sabine M.P., Antonio, Leen, Gielen, Evelien, Rutter, Martin K., Vanderschueren, Dirk, Wu, Frederick C.W., and Tournoy, Jos

Published
2017
Full Text
View/download PDF

6. Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study

Author

Overman, Margot J., Pendleton, Neil, O’Neill, Terence W., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Rastrelli, Giulia, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Lee, David M., Correa, Elon S., Ahern, Tomas, Verschueren, Sabine M. P., Antonio, Leen, Gielen, Evelien, Rutter, Martin K., Vanderschueren, Dirk, Wu, Frederick C. W., Tournoy, Jos, and The EMAS Study Group

Published
2017
Full Text
View/download PDF

8. Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS)

Author

Han, Thang S., Correa, Elon, Lean, Michael E. J., Lee, David M., O’Neill, Terrence W., Bartfai, György, Forti, Gianni, Giwercman, Aleksander, Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Rutter, Martin K., Vanderschueren, Dirk, Huhtaniemi, Ilpo T., Wu, Frederick C. W., Casanueva, Felipe F., and and the EMAS Study Group

Published
2017
Full Text
View/download PDF

10. Reproductive hormone levels, androgen receptor CAG repeat length and their longitudinal relationships with decline in cognitive subdomains in men: The European Male Ageing Study.

Author

Overman, Margot J, primary, Pendleton, Neil, additional, O'Neill, Terence W, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe F, additional, Forti, Gianni, additional, Rastrelli, Giulia, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Huhtaniemi, Ilpo T, additional, Slowikowska-Hilczer, Jolanta, additional, Lean, Michael EJ, additional, Punab, Margus, additional, Lee, David M, additional, Antonio, Leen, additional, Gielen, Evelien, additional, Rutter, Martin K, additional, Vanderschueren, Dirk, additional, Wu, Frederick CW, additional, and Tournoy, Jos, additional

Published
2022
Full Text
View/download PDF

11. Elevated luteinizing hormone despite normal testosterone levels in older men—natural history, risk factors and clinical features

Author

Eendebak, Robert J. A. H., Ahern, Tomas, Swiecicka, Agnieszka, Pye, Stephen R., OʼNeill, Terence W., Bartfai, Gyorgy, Casanueva, Felipe F., Maggi, Mario, Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Słowikowska‐Hilczer, Jolanta, Lean, Michael E. J., Punab, Margus, Pendleton, Neil, Keevil, Brian G., Vanderschueren, Dirk, Rutter, Martin K., Tampubolon, Gindo, Goodacre, Royston, Huhtaniemi, Ilpo T., and Wu, Frederick C. W.

Published
2018
Full Text
View/download PDF

12. Reproductive Hormone Levels Predict Changes in Frailty Status in Community-Dwelling Older Men: European Male Ageing Study Prospective Data

Author

Swiecicka, Agnieszka, Eendebak, Robert J A H, Lunt, Mark, O’Neill, Terence W, Bartfai, György, Casanueva, Felipe F, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Slowikowska-Hilczer, Jolanta, Lean, Michael E J, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Huhtaniemi, Ilpo T, Wu, Frederick C W, and Rutter, Martin K

Published
2018
Full Text
View/download PDF

16. Chronic widespread pain is associated with worsening frailty in European men

Author

Wade, Katie Fredrika, Lee, David M., McBeth, John, Ravindrarajah, Rathi, Gielen, Evelien, Pye, Stephen R., Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Punab, Margus, Wu, Frederick C. W., and OʼNeill, Terence W.

Published
2016
Full Text
View/download PDF

17. Aging Men With Insufficient Vitamin D Have a Higher Mortality Risk: No Added Value of its Free Fractions or Active Form

Author

Dejaeger, Marian, primary, Antonio, Leen, additional, Bouillon, Roger, additional, Moors, Hannes, additional, Wu, Frederick C W, additional, O’Neill, Terence W, additional, Huhtaniemi, Ilpo T, additional, Rastrelli, Giulia, additional, Forti, Gianni, additional, Maggi, Mario, additional, Casanueva, Felipe F, additional, Slowikowska-Hilczer, Jolanta, additional, Punab, Margus, additional, Gielen, Evelien, additional, Tournoy, Jos, additional, and Vanderschueren, Dirk, additional

Published
2021
Full Text
View/download PDF

18. Low heel ultrasound parameters predict mortality in men: results from the European Male Ageing Study (EMAS)

Author

Pye, Stephen R., Vanderschueren, Dirk, Boonen, Steven, Gielen, Evelien, Adams, Judith E., Ward, Kate A., Lee, David M., Bartfai, György, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E., Pendleton, Neil, Punab, Margus, Wu, Frederick C., and OʼNeill, Terence W.

Published
2015
Full Text
View/download PDF

20. Associations Between Sex Steroids and the Development of Metabolic Syndrome: A Longitudinal Study in European Men

Author

Antonio, Leen, Wu, Frederick C. W., OʼNeill, Terence W., Pye, Stephen R., Carter, Emma L., Finn, Joseph D., Rutter, Martin K., Laurent, Michaël R., Huhtaniemi, Ilpo T., Han, Thang S., Lean, Michael E. J., Keevil, Brian G., Pendleton, Neil, Rastrelli, Giulia, Forti, Gianni, Bartfai, Gyorgy, Casanueva, Felipe F., Kula, Krzysztof, Punab, Margus, Giwercman, Aleksander, Claessens, Frank, Decallonne, Brigitte, and Vanderschueren, Dirk

Published
2015

21. Sexual symptoms predict all-cause mortality independently of sex steroids in ageing men

Author

Antonio Leen, Dejaeger Marian, Wu Frederick CW, Terence WO'Neil, Pye Stephen R, Huhtaniemi Ilpo T, Rastrelli Giulia, Forti Gianni, Casanueva Felipe F, Slowikowska-Hilczer Jolanta, Punab Margus, Vanderschueren Dirk, and Tournoy Jos

Subjects
business.industry, Ageing, Medicine, business, Sexual symptoms, All cause mortality, Demography
Published
2020

23. European Academy of Andrology (EAA) guidelines* on investigation, treatment and monitoring of functional hypogonadism in males

Author

Corona, Giovanni, Goulis, Dimitrios G, Huhtaniemi, Ilpo, Zitzmann, Michael, Toppari, Jorma, Forti, Gianni, Vanderschueren, Dirk, and Wu, Frederick C

Subjects
cardiovascular risk, libido, obesity, erectile dysfunction, testosterone, functional hypogonadism, late-onset hypogonadism
Abstract

BACKGROUND: Evidence regarding functional hypogonadism, previously referred to as 'late-onset' hypogonadism, has increased substantially during the last 10 year. OBJECTIVE: To update the European Academy of Andrology (EAA) guidelines on functional hypogonadism. METHODS: Expert group of academicians appointed by the EAA generated a series of consensus recommendations according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) system. RESULTS: The diagnosis of functional hypogonadism should be based on both the presence of clinical symptoms supported by repeatedly low morning fasting serum total testosterone (T) measured with a well-validated assay, after exclusion of organic causes of hypogonadism. Lifestyle changes and weight reduction should be the first approach in all overweight and obese men. Whenever possible, withdrawal/modification of drugs potentially interfering with T production should be advised. Testosterone replacement therapy (TRT) is contraindicated in men with untreated prostate or breast cancer, as well as severe heart failure. Severe low urinary tract symptoms and haematocrit >48%-50% represent relative contraindications for TRT. Prostate-specific antigen and digital rectal examination of the prostate should be undertaken in men >40 years of age before initiating TRT to exclude occult prostate cancer. Transdermal T should be preferred for initiation of TRT, whereas gonadotrophin therapy is only recommended when fertility is desired in men with secondary hypogonadism. TRT is able to improve sexual function in hypogonadal men. Other potential positive outcomes of TRT remain uncertain and controversial. CONCLUSION: TRT can reliably improve global sexual function in men with hypogonadism in the short term. Long-term clinical benefits, and safety of TRT in functional hypogonadism, remain to be fully documented. Clinicians should therefore explicitly discuss the uncertainties and benefits of TRT and engage them in shared management decision-making. ispartof: ANDROLOGY vol:8 issue:5 pages:970-987 ispartof: location:England status: published

Published
2020

24. Erectile dysfunction predicts mortality in middle-aged and older men independent of their sex steroid status.

Author

Antonio, Leen, Wu, Frederick C W, Moors, Hannes, Matheï, Cathy, Huhtaniemi, Ilpo T, Rastrelli, Giulia, Dejaeger, Marian, O'Neill, Terence W, Pye, Stephen R, Forti, Gianni, Maggi, Mario, Casanueva, Felipe F, Slowikowska-Hilczer, Jolanta, Punab, Margus, Tournoy, Jos, Vanderschueren, Dirk, and Group, the EMAS Study

Subjects
MORTALITY risk factors, SEXUAL dysfunction, IMPOTENCE, CONFIDENCE intervals, TESTOSTERONE, RISK assessment, SEX hormones, INDEPENDENT living, QUESTIONNAIRES, MASS spectrometry, DESCRIPTIVE statistics, MALE reproductive organ diseases, PROPORTIONAL hazards models, HYPOACTIVE sexual desire disorder, SYMPTOMS, OLD age
Abstract

Background erectile dysfunction is associated with mortality, whereas the association between low testosterone (T) and higher mortality remains controversial. Sexual dysfunction and low T often coexist, but the relative importance of sexual symptoms versus low T in predicting mortality is not known. We studied the interrelationships between sex steroids and sexual symptoms with all-cause mortality in a large prospective cohort of European men. Design survival status was assessed in 1,788 community-dwelling men, aged 40–79, who participated in the European Male Ageing Study (EMAS). Sexual symptoms were evaluated via a validated questionnaire (EMAS-SFQ). Sex steroids were measured by mass spectrometry. Cox proportional hazard models were used to study the association between hormones, sexual symptoms and mortality. Results about 420 (25.3%) men died during a mean follow-up of 12.6 ± 3.1 years. Total T levels were similar in both groups, but free T was lower in those who died. Men with three sexual symptoms (erectile dysfunction, reduced morning erections and lower libido) had a higher mortality risk compared with men with none of these symptoms (adjusted hazard ratio (HR) and 95% confidence intervals: 1.75 (1.28–2.40, P  = 0.001)). Particularly, erectile dysfunction and poor morning erections, but not lower libido, were associated with increased mortality (HR 1.40 (1.13–1.74, P  = 0.002), 1.28 (1.04–1.59, P  = 0.023) and 1.12 (0.90–1.39, P  = 0.312), respectively). Further adjusting for total T, free T or oestradiol did not influence the observed risk. Conclusions sexual symptoms, in particular erectile dysfunction, predict all-cause mortality independently of sex steroids and can be an early warning sign of a poor health status. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

25. Aging Men With Insufficient Vitamin D Have a Higher Mortality Risk: No Added Value of its Free Fractions or Active Form.

Author

Dejaeger, Marian, Antonio, Leen, Bouillon, Roger, Moors, Hannes, Wu, Frederick C. W., O'Neill, Terence W., Huhtaniemi, Ilpo T., Rastrelli, Giulia, Forti, Gianni, Maggi, Mario, Casanueva, Felipe F., Slowikowska-Hilczer, Jolanta, Punab, Margus, Gielen, Evelien, Tournoy, Jos, and Vanderschueren, Dirk

Subjects
VITAMIN D, SMOKING, MORTALITY
Abstract

Context: Low total 25-hydroxyvitamin D (25(OH)D) has been associated with mortality. Whether vitamin D in its free form or 1,25-dihydroxyvitamin D (1,25(OH)2D), provide any additional information is unclear. Objective: To determine what level of 25(OH)D is predictive for mortality and if free 25(OH)D or 1,25(OH) 2 D concentrations have any added value. Methods: This prospective cohort comprised 1915 community-dwelling men, aged 40 to 79 years. Intervention included determination of association of total and free 25(OH)D and 1,25(OH) 2 D concentrations with survival status. Vitamin D results were grouped into quintiles. For total 25(OH)D, specific cutoff values were also applied. Cox proportional hazard models were used adjusted for center, body mass index, smoking, alcohol, physical activity, season of blood sample, kidney function, and number of comorbidities. Results: A total of 469 (23.5%) men died during a mean follow-up of 12.3 ± 3.4 years. Compared to those with normal vitamin D values (> 30 µg/L), men with a total 25(OH)D of less than 20 µg/L had an increased mortality (hazard ratio [HR] 2.03 [95% CI, 1.39-2.96]; P < .001). Likewise, men in the lowest 3 free 25(OH)D quintiles (< 4.43 ng/L) had a higher mortality risk compared to the highest quintile (HR 2.09 [95% CI, 1.34-3.25]; P < .01). Mortality risks were similar across all 1,25(OH)2D and vitamin D binding protein quintiles. Conclusion: Aging men with vitamin D deficiency have a 2-fold increased mortality risk. Determinations of either the free fractions of vitamin D or measurement of its active form offer no additional information on mortality risks. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

26. Free 25-hydroxyvitamin D, but not free 1.25-dihydroxyvitamin D, predicts all-cause mortality in ageing men

Author

Antonio, Leen, primary, Dejaeger, Marian, additional, Bouillon, Roger, additional, Wu, Frederick, additional, O’Neill, Terence, additional, Pye, Stephen, additional, Huhtaniemi, Ilpo, additional, Rastrelli, Giulia, additional, Forti, Gianni, additional, Casanueva, Felipe, additional, Slowikowska-Hilczer, Jolanta, additional, Punab, Margus, additional, Tournoy, Jos, additional, and Vanderschueren, Dirk, additional

Published
2020
Full Text
View/download PDF

27. OR02-06 Sexual Symptoms Predict All-Cause Mortality Independently of Sex Steroids in Ageing Men

Author

Antonio, Leen, primary, Dejaeger, Marian, primary, Wu, Frederick C, primary, O’Neill, Terence, primary, Pye, Stephen, primary, Huhtaniemi, Ilpo T, primary, Rastrelli, Giulia, primary, Forti, Gianni, primary, Casanueva, Felipe F, primary, Slowikowska-Hilczer, Jolanta, primary, Punab, Margus, primary, Vanderschueren, Dirk M, primary, and Tournoy, Jos, primary

Published
2020
Full Text
View/download PDF

28. European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males

Author

Corona, Giovanni, primary, Goulis, Dimitrios G., additional, Huhtaniemi, Ilpo, additional, Zitzmann, Michael, additional, Toppari, Jorma, additional, Forti, Gianni, additional, Vanderschueren, Dirk, additional, Wu, Frederick C., additional, Corona, G., additional, Goulis, D.G., additional, Forti, G., additional, Behre, H.M., additional, Punab, M., additional, Toppari, J., additional, Krausz, C., additional, Rajpert‐De Meyts, E, additional, Tüttelmann, F, additional, Isidori, A.M., additional, Ruiz‐Castane, E, additional, Jezek, D, additional, Kopa, Z, additional, and Simoni, M., additional

Published
2020
Full Text
View/download PDF

29. Symptomatic androgen deficiency develops only when both total and free testosterone decline in obese men who may have incident biochemical secondary hypogonadism: prospective results from the EMAS

Author

Rastrelli, Giulia, Eendebak, Robert J.A.H., O'Neill, Terence W., Ahern, Tomas, Gyorgy, Bartfai, Casanueva, Felipe F., Forti, Gianni, Keevil, Brian, Giwercman, Aleksander, Han, Thang S., Slowikowska-Hilczer, Jolanta, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Antonio, Leen, Tournoy, Jos, Vanderschueren, Dirk, Maggi, Mario, Huhtaniemi, Ilpo T., and Wu, Frederick C.W.

Abstract

Objective: \ud Limited evidence supports the use of free testosterone (FT) for diagnosing hypogonadism when sex hormone binding globulin (SHBG) is altered. Low total testosterone (TT) is commonly encountered in obesity where SHBG is typically decreased. We aimed to assess the contribution of FT in improving the diagnosis of symptomatic secondary hypogonadism (SH), identified initially by low total testosterone (TT), and then further differentiated by normal FT (LNSH) or low FT (LLSH).\ud \ud Design: \ud Prospective observational study with a median follow‐up of 4.3 years.\ud \ud Patients: \ud 3369 community‐dwelling men aged 40‐79 years from eight European centres.\ud \ud Measurements: \ud Subjects were categorised according to baseline and follow‐up biochemical status into persistent eugonadal (referent group; n=1880), incident LNSH (eugonadism to LNSH; n=101) and incident LLSH (eugonadism to LLSH; n=38). Predictors and clinical features associated with the transition from eugonadism to LNSH or LLSH were assessed.\ud \ud Results: \ud The cumulative incidence of LNSH and LLSH over 4.3 years was 4.9% and 1.9% respectively. Baseline obesity predicted both LNSH and LLSH but the former occurred more frequently in younger men. LLSH, but not LNSH, was associated with new/worsened sexual symptoms, including low desire [OR= 2.67 (1.27‐5.60)], erectile dysfunction [OR= 4.53 (2.05‐10.01)] and infrequent morning erections [OR= 3.40 (1.48‐7.84)].\ud \ud Conclusions: \ud These longitudinal data demonstrate the importance of FT in the diagnosis of hypogonadism in obese men with low TT and SHBG. The concurrent fall in TT and FT identifies the minority (27.3%) of men with hypogonadal symptoms, which were not present in the majority developing low TT with normal FT.

Published
2018

30. Reproductive hormone levels predict changes in frailty status in community-dwelling older men:European Male Ageing Study prospective data

Author

Swiecicka, Agnieszka, Eendebak, Robert J.A.H., Lunt, Mark, O'Neill, Terence W., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Slowikowska-Hilczer, Jolanta, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Huhtaniemi, Ilpo T., Wu, Frederick C.W., and Rutter, Martin K.

Abstract

CONTEXT: Clinical sequelae of androgen deficiency share common features with frailty. Evidence supporting the role of androgens in the development of frailty is limited and conflicting. OBJECTIVE: To determine associations between male reproductive hormones and prospective changes in frailty status. DESIGN/SETTING: A 4.3-year prospective cohort study of community-dwelling men participating in the European Male Ageing Study. PARTICIPANTS: A total of 3369 men aged 40 to 79 from eight European centers. INTERVENTION: None. MAIN OUTCOME MEASURE: Frailty status was determined using frailty index (FI; n = 2278) and frailty phenotype (FP; n = 1980). RESULTS: After adjusting for baseline frailty, age, center, and smoking, the risk of worsening FI decreased with higher testosterone (T), free T, and dihydrotestosterone (DHT) [percentage change (95% confidence interval) in FI associated with 1 standard deviation higher hormone level: -3.0 (-5.9, -1.0) for total T; -3.9 (-6.8, -2.0) for free T; and -3.9 (-6.8, -2.0) for DHT]. After further adjustment for body mass index, only free T remained a significant predictor of FI change. In fully adjusted models, higher luteinizing hormone and follicle-stimulating hormone were positively related to worsening FI only in men

Published
2018

31. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study

Author

McCabe, Paul S., Pye, Stephen, Mcbeth, John, Lee, David M, Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C, and O'Neill, Terence

Subjects
GENERAL-POPULATION, Science & Technology, Chronic Widespread pain, Epidemiology, Depression, 1103 Clinical Sciences, R1, PREVALENCE, D DEFICIENCY, PERSISTENT, EMAS Study Group, Orthopedics, Rheumatology, ONSET, Chronic Widespread Pain, Orthopedics and Sports Medicine, Obesity, Chronic Pain, Vitamin D, Life Sciences & Biomedicine, MUSCULOSKELETAL PAIN, MANCHESTER, FIBROMYALGIA, BONE HEALTH
Abstract

BACKGROUND: The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. METHODS: Three thousand three hundred sixty nine men aged 40-79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. RESULTS: Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5%) developed new CWP at follow up and 577 (24.9%) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (

Published
2016

34. The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men

Author

Eendebak, Robert J A H, primary, Huhtaniemi, Ilpo T, additional, Pye, Stephen R, additional, Ahern, Tomas, additional, O’Neill, Terence W, additional, Bartfai, György, additional, Casanueva, Felipe F, additional, Maggi, Mario, additional, Forti, Gianni, additional, Alston, Robert D, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Kula, Krzysztof, additional, Lean, Michael E J, additional, Punab, Margus, additional, Pendleton, Neil, additional, Keevil, Brian G, additional, Vanderschueren, Dirk, additional, Rutter, Martin K, additional, Tampubolon, Gindo, additional, Goodacre, Royston, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2016
Full Text
View/download PDF

35. Frailty and bone health in European men

Author

Cook, Michael J., primary, Oldroyd, Alexander, additional, Pye, Stephen R., additional, Ward, Kate A., additional, Gielen, Evelien, additional, Ravindrarajah, Rathi, additional, Adams, Judith E., additional, Lee, David M., additional, Bartfai, Gyorgy, additional, Boonen, Steven, additional, Casanueva, Felipe, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S., additional, Huhtaniemi, Ilpo T., additional, Kula, Krzysztof, additional, Lean, Michael E., additional, Pendleton, Neil, additional, Punab, Margus, additional, Vanderschueren, Dirk, additional, Wu, Frederick C., additional, and O'Neill, Terence W., additional

Published
2016
Full Text
View/download PDF

37. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study

Author

Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, McCabe, Paul S., Pye, Stephen R., Mc Beth, John, Lee, David M., Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva Freijo, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C., O’Neill, Terence W., EMAS Study Group, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, McCabe, Paul S., Pye, Stephen R., Mc Beth, John, Lee, David M., Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva Freijo, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C., O’Neill, Terence W., and EMAS Study Group

Abstract

Background The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. Methods Three thousand three hundred sixty nine men aged 40–79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. Results Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5 %) developed new CWP at follow up and 577 (24.9 %) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (<15.6 ng/mL) were more likely to develop CWP (Odds Ratio [OR] = 1.93; 95 % CI = 1.0-3.6). Further adjustment for BMI (OR = 1.67; 95 % CI = 0.93-3.02) or depression (OR = 1.77; 95 % CI = 0.98-3.21), however rendered the association non-significant. Conclusions Low vitamin D is linked with the new occurrence of CWP, although this may be explained by underlying adverse health factors, particularly obesity and depression.

Published
2016

38. P2-419: Evaluation of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D and Cognitive Decline in the European Male Ageing Study

Author

Tournoy, Jos, primary, Overman, Margot, additional, Pendleton, Neil, additional, O'Neill, Terence, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe, additional, Forti, Gianni, additional, Rastrelli, Giulia, additional, Giwercman, Aleksander, additional, Han, Thang, additional, Huhtaniemi, Ilpo, additional, Kula, Krzysztof, additional, Lean, Michael, additional, Punab, Margus, additional, Lee, David, additional, Correa, Elon, additional, Verschueren, Sabine, additional, Antonio, Leen, additional, Gielen, Evelien, additional, Rutter, Martin, additional, Vanderschueren, Dirk, additional, and Wu, Frederick, additional

Published
2016
Full Text
View/download PDF

39. A novel human fetal brown stem cell functional model to study brown adipogenesis

Author

Franco, Alessandra Di, primary, Guasti, Daniele, additional, Squecco, Roberta, additional, Mazzanti, Benedetta, additional, Rossi, Francesca, additional, Idrizaj, Eglantina, additional, Gallego-Escuredo, Jose, additional, Villarroya, Francesc, additional, Bani, Daniele, additional, Forti, Gianni, additional, Vannelli, Gabriella Barbara, additional, and Luconi, Michaela, additional

Published
2016
Full Text
View/download PDF

40. Variation of DNA Fragmentation Levels During Density Gradient Sperm Selection for Assisted Reproduction Techniques

Author

Muratori, Monica, primary, Tarozzi, Nicoletta, additional, Cambi, Marta, additional, Boni, Luca, additional, Iorio, Anna Lisa, additional, Passaro, Claudia, additional, Luppino, Benedetta, additional, Nadalini, Marco, additional, Marchiani, Sara, additional, Tamburrino, Lara, additional, Forti, Gianni, additional, Maggi, Mario, additional, Baldi, Elisabetta, additional, and Borini, Andrea, additional

Published
2016
Full Text
View/download PDF

42. Searching for Classical Brown Fat in Humans: Development of a Novel Human Fetal Brown Stem Cell Model

Author

Di Franco, Alessandra, primary, Guasti, Daniele, additional, Squecco, Roberta, additional, Mazzanti, Benedetta, additional, Rossi, Francesca, additional, Idrizaj, Eglantina, additional, Gallego-Escuredo, José M., additional, Villarroya, Francesc, additional, Bani, Daniele, additional, Forti, Gianni, additional, Vannelli, Gabriella Barbara, additional, and Luconi, Michaela, additional

Published
2016
Full Text
View/download PDF

43. Low heel ultrasound parameters predict mortality in men: results from the European Male Ageing Study (EMAS).

Author

Pye, Stephen R, Vanderschueren, Dirk, Boonen, Steven, Gielen, Evelien, Adams, Judith E, Ward, Kate A, Lee, David M, Bartfai, György, Casanueva, Felipe F, Finn, Joseph D, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael E, Pendleton, Neil, Punab, Margus, Wu, Frederick C, O'Neill, Terence W, Pye, Stephen R, Vanderschueren, Dirk, Boonen, Steven, Gielen, Evelien, Adams, Judith E, Ward, Kate A, Lee, David M, Bartfai, György, Casanueva, Felipe F, Finn, Joseph D, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael E, Pendleton, Neil, Punab, Margus, Wu, Frederick C, and O'Neill, Terence W

Abstract

low bone mineral density measured by dual-energy x-ray absorptiometry is associated with increased mortality. The relationship between other skeletal phenotypes and mortality is unclear. The aim of this study was to determine the relationship between quantitative heel ultrasound parameters and mortality in a cohort of European men.

Published
2015

44. Chronic widespread pain is associated with worsening frailty in European men

Author

Wade, Katie Fredrika, primary, Lee, David M., additional, McBeth, John, additional, Ravindrarajah, Rathi, additional, Gielen, Evelien, additional, Pye, Stephen R., additional, Vanderschueren, Dirk, additional, Pendleton, Neil, additional, Finn, Joseph D., additional, Bartfai, György, additional, Casanueva, Felipe F., additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Huhtaniemi, Ilpo T., additional, Kula, Krzysztof, additional, Punab, Margus, additional, Wu, Frederick C. W., additional, and O'Neill, Terence W., additional

Published
2015
Full Text
View/download PDF

45. Massive Weight Loss Obtained by Bariatric Surgery Affects Semen Quality in Morbid Male Obesity: a Preliminary Prospective Double-Armed Study.

Author

Samavat, Jinous, Cantini, Giulia, Lotti, Francesco, Franco, Alessandra, Tamburrino, Lara, Degl'innocenti, Selene, Maseroli, Elisa, Filimberti, Erminio, Facchiano, Enrico, Lucchese, Marcello, Muratori, Monica, Forti, Gianni, Baldi, Elisabetta, Maggi, Mario, and Luconi, Michaela

Subjects
WEIGHT loss, BARIATRIC surgery, SEMEN analysis, OBESITY in men, SEX hormones
Abstract

Objectives: The aim of this study is to evaluate the effect of massive weight loss on the seminal parameters at 6 months from bariatric surgery. Design: Two-armed prospective study performed in 31 morbidly obese men, undergoing laparoscopic roux-en-Y-gastric bypass ( n = 23) or non-operated ( n = 8), assessing sex hormones, conventional (sperm motility, morphology, number, semen volume), and non-conventional (DNA fragmentation and seminal interleukin-8), semen parameters, at baseline and after 6 months from surgery or patients' recruitment. Results: In operated patients only, a statistically significant improvement in the sex hormones was confirmed. Similarly, a positive trend in the progressive/total sperm motility and number was observed, though only the increase in semen volume and viability was statistically significant (Δ = 0.6 ml and 10%, P < 0.05, respectively). A decrease in the seminal interleukin-8 levels and in the sperm DNA fragmentation was also present after bariatric surgery, whereas these parameters even increased in non-operated subjects. Age-adjusted multivariate analysis showed that the BMI variations significantly correlated with the changes in the sperm morphology ( β = −0.675, P = 0.025), sperm number ( β = 0.891, P = 0.000), and semen volume ( r = 0.618, P = 0.015). Conclusion: The massive weight loss obtained with bariatric surgery was associated with an improvement in some semen parameters. The correlations found between weight loss and semen parameter variations after surgery suggest that these might occur early downstream of the testis and more slowly than the changes in the sex hormones. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

46. Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone levels: results from the European Male Ageing Study

Author

Antonio, Leen, primary, Wu, Frederick, additional, O'Neill, Terrence, additional, Pye, Stephen, additional, Carter, Emma, additional, Finn, Joseph, additional, Laurent, Michaël, additional, Huhtaniemi, Ilpo, additional, Rutter, Martin, additional, Rastrelli, Giulia, additional, Forti, Gianni, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe, additional, Kula, Krzysztof, additional, Punab, Margus, additional, Giwercman, Aleksander, additional, Claessens, Frank, additional, Decallonne, Brigitte, additional, and Vanderschueren, Dirk, additional

Published
2015
Full Text
View/download PDF

48. Low free testosterone is associated with hypogonadal symptoms in men with normal total testosterone levels: results from the European Male Ageing Study

Author

Antonio, Leen, primary, Wu, Frederic, additional, O'Neill, Terrence, additional, Pye, Stephen, additional, Carter, Emma, additional, Finn, Joseph, additional, Laurent, Michael, additional, Huhtaniemi, Ilpo, additional, Rutter, Martin, additional, Rastrelli, Giulia, additional, Forti, Gianni, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe, additional, Kula, Krzysztof, additional, Punab, Margus, additional, Giwercman, Aleksander, additional, Claessens, Frank, additional, Decallonne, Brigitte, additional, and Vanderschueren, Dirk, additional

Published
2015
Full Text
View/download PDF

49. Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

Author

Ahern, Tomas B, primary, Huhtaniemi, Ilpo T, additional, Carter, Emma L, additional, Finn, Joseph D, additional, Pye, Stephen R, additional, O'Neill, Terence W, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe F, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Kula, Krzysztof, additional, Lean, Michael EJ, additional, Pendleton, Neil, additional, Punab, Margus, additional, Vanderschueren, Dirk, additional, and Wu, Frederick C W, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results