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Your search keyword '"Fan, Ruoxi"' showing total 9 results
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9 results on '"Fan, Ruoxi"'

2. Chromosome‐level reference genome and resequencing of 322 accessions reveal evolution, genomic imprint and key agronomic traits in adzuki bean

Author

Chu, Liwei, primary, Yang, Kai, additional, Chen, Chunhai, additional, Zhao, Bo, additional, Hou, Yanan, additional, Wang, Wanqiu, additional, Zhao, Pu, additional, Wang, Kaili, additional, Wang, Binhu, additional, Xiao, Ying, additional, Li, Yongqiang, additional, Li, Yisong, additional, Song, Qijian, additional, Liu, Biao, additional, Fan, Ruoxi, additional, Bohra, Abhishek, additional, Yu, Jianping, additional, Sonnenschein, Eva C., additional, Varshney, Rajeev K, additional, Tian, Zhixi, additional, Jian, Jianbo, additional, and Wan, Ping, additional

Published
2024
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4. P-hydroxy benzaldehyde facilitates reprogramming of reactive astrocytes into neurons via endogenous transcriptional regulation.

Author

Li, Xin, Fan, Ruoxi, Xiang, Jianming, Yuan, Yajin, Mao, Xiaojian, and Zhou, Ningna

Subjects
*GENETIC transcription regulation, *NEURONS, *BENZALDEHYDE, *ASTROCYTES, *CEREBRAL ischemia, *POINT processes, *PLURIPOTENT stem cells, *TRANSCRIPTION factors, *HYDROXYCINNAMIC acids
Abstract

Cerebral ischemia leads to linguistic and motor dysfunction, as the death of neurons in ischemic core is permanent and non-renewable. An innovative avenue is to induce and/or facilitate reprogramming of adjacent astrocytes into neurons to replace the lost neurons and re-establish brain homeostasis. This study aimed to investigate whether the p-hydroxy benzaldehyde (p-HBA), a phenolic compound isolated from Gastrodia elata Blume, could facilitate the reprogramming of oxygen-glucose deprivation/reperfusion (OGD/R)-damaged astrocytes into neurons. The primary parenchymal astrocytes of rat were exposure to OGD and reperfusion with define culture medium. Cells were then incubated with different concentration of p-HBA (1, 10, 100, 400 μM) and collected at desired time point for reprogramming process analysis. OGD/R could elicit endogenous neurogenic program in primary parenchymal astrocytes of rat under define culture condition, and these so-called reactive astrocytes could be reprogrammed into neurons. However, the neonatal neurons produced by this endogenous procedure could not develop into mature neurons, and the conversion rate was only 1.9%. Treatment of these reactive astrocytes with p-HBA could successfully promote the conversion rate to 6.1%, and the neonatal neurons could develop into mature neurons within 14 days. Further analysis showed that p-HBA down-regulated the Notch signal component genes Dll1, Hes1 and SOX2, while the transcription factor NeuroD1 was up-regulated. The results of this study demonstrated that p-HBA facilitated the astrocyte-to-neuron conversion. This chemical reprogramming was mediated by inhibition of Notch1 signaling pathway and transcriptional activation of NeuroD1. [ABSTRACT FROM AUTHOR]

Published
2023
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7. The origin of chow chows in the light of the East Asian breeds

Author

Yang, Hechuan, primary, Wang, Guodong, additional, Wang, Meng, additional, Ma, Yaping, additional, Yin, Tingting, additional, Fan, Ruoxi, additional, Wu, Hong, additional, Zhong, Li, additional, Irwin, David M., additional, Zhai, Weiwei, additional, and Zhang, Yaping, additional

Published
2017
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