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2. Finding women in fishing communities around Lake Victoria: "Feasibility and acceptability of using phones and tracking devices".

Author

Nanyonjo, Gertrude, Kwena, Zachary, Nakamanya, Sarah, Okello, Elialilia, Oketch, Bertha, Bahemuka, Ubaldo M., Ssetaala, Ali, Okech, Brenda, Price, Matt A., Kapiga, Saidi, Fast, Pat, Bukusi, Elizabeth, and Seeley, Janet

Subjects
FISHING villages, FISH communities, SIM cards, GPS receivers, GLOBAL Positioning System
Abstract

Introduction: Women in fishing communities have both high HIV prevalence and incidence, hence they are a priority population for HIV prevention and treatment interventions. However, their mobility is likely to compromise the effectiveness of interventions. We assessed the acceptability, feasibility and of using phones and global positioning system (GPS) devices for tracking mobility, to inform future health research innovations. Methods: A mult-site formative qualitative study was conducted in six purposively selected Fishing Communities on the shores of Lake Victoria in Kenya, Tanzania, and Uganda. Participants were selected based on duration of stay in the community and frequency of movement. Sixty-four (64) women participated in the study (16 per fishing community). Twenty-four (24) participants were given a study phone; 24 were asked to use their own phones and 16 were provided with a portable GPS device to understand what is most preferred. Women were interviewed about their experiences and recommendations on carrying GPS devices or phones. Twenty four (24) Focus Group Discussions with 8–12 participants were conducted with community members to generate data on community perceptions regarding GPS devices and phones acceptability among women. Data were analyzed thematically and compared across sites/countries. Results: Women reported being willing to use tracking devices (both phones and GPS) because they are easy to carry. Their own phone was preferred compared to a study phone and GPS device because they were not required to carry an additional device, worry about losing it or be questioned about the extra device by their sexual partner. Women who carried GPS devices suggested more sensitization in communities to avoid domestic conflicts and public concern. Women suggested changing the GPS colour from white to a darker colour and, design to look like a commonly used object such as a telephone Subscriber Identity Module (SIM) card, a rosary/necklace or a ring for easy and safe storage. Conclusion: Women in the study communities were willing to have their movements tracked, embraced the use of phones and GPS devices for mobility tracking. Devices need to be redesigned to be more discrete, but they could be valuable tools to understanding movement patterns and inform design of interventions for these mobile populations. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses

Author

Muir, Roshell, primary, Metcalf, Talibah, additional, Fourati, Slim, additional, Bartsch, Yannic, additional, Kyosiimire-Lugemwa, Jacqueline, additional, Canderan, Glenda, additional, Alter, Galit, additional, Muyanja, Enoch, additional, Okech, Brenda, additional, Namatovu, Teddy, additional, Namara, Irene, additional, Namuniina, Annemarie, additional, Ssetaala, Ali, additional, Mpendo, Juliet, additional, Nanvubya, Annet, additional, Kitandwe, Paul Kato, additional, Bagaya, Bernard S., additional, Kiwanuka, Noah, additional, Nassuna, Jacent, additional, Biribawa, Victoria Menya, additional, Elliott, Alison M., additional, de Dood, Claudia J., additional, Senyonga, William, additional, Balungi, Priscilla, additional, Kaleebu, Pontiano, additional, Mayanja, Yunia, additional, Odongo, Matthew, additional, Connors, Jennifer, additional, Fast, Pat, additional, Price, Matt A., additional, Corstjens, Paul L. A. M., additional, van Dam, Govert J., additional, Kamali, Anatoli, additional, Sekaly, Rafick Pierre, additional, and Haddad, Elias K., additional

Published
2023
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4. Schistosoma mansoniinfection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses

Author

Muir, Roshell, primary, Metcalf, Talibah, additional, Fourati, Slim, additional, Bartsch, Yannic, additional, Lugemwa, Jacqueline Kyosiimire, additional, Canderan, Glenda, additional, Alter, Galit, additional, Muyanja, Enoch, additional, Okech, Brenda, additional, Namatovu, Teddy, additional, Namara, Irene, additional, Namuniina, Annemarie, additional, Ssetaala, Ali, additional, Mpendo, Juliet, additional, Nanvubya, Annet, additional, Kitandwe, Paul Kato, additional, Bagaya, Bernard S., additional, Kiwanuka, Noah, additional, Nassuna, Jacent, additional, Biribawa, Victoria Menya, additional, Elliott, Alison M., additional, de Dood, Claudia J., additional, Senyonga, William, additional, Balungi, Priscilla, additional, Kaleebu, Pontiano, additional, Mayanja, Yunia, additional, Odongo, Mathew, additional, Fast, Pat, additional, Price, Matt A., additional, Corstjens, Paul L.A.M., additional, van Dam, Govert J., additional, Kamali, Anatoli, additional, Sekaly, Rafick Pierre, additional, and Haddad, Elias K, additional

Published
2023
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5. HIV vaccine-induced sero-reactivity: A challenge for trial participants, researchers, and physicians

Author

Voronin, Yegor, Zinszner, Helene, Karg, Carissa, Brooks, Katie, Coombs, Robert, Hural, John, Holt, Renee, Fast, Pat, Allen, Mary, Busch, Michael, Fruth, Ulrich, Golding, Hana, Khurana, Surender, Mulenga, Joseph, Peel, Sheila, Schito, Marco, Barnabas, Nomampondo, Bentsen, Christopher, Graham, Barney, Gray, Glenda, Levin, Andrew, McCluskey, Margaret, O’Connell, Robert, Snow, Bill, and Ware, Mark

Published
2015
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7. Social networks, mobility, and HIV risk among women in the fishing communities of Lake Victoria

Author

Nakamanya, Sarah, primary, Okello, Elialilia S., additional, Kwena, Zachary A, additional, Nanyonjo, Gertrude, additional, Bahemuka, Ubaldo M, additional, Kibengo, Freddie M, additional, Ssetaala, Ali, additional, Bukusi, Elizabeth, additional, Kapiga, Saidi, additional, Fast, Pat, additional, Seeley, Janet, additional, and Kidega, The Lake Victoria Consortium for Health Research (LVCHR), additional

Published
2022
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8. Measles immunity gap among reproductive-age women participating in a simulated HIV vaccine efficacy trial in Zambia

Author

Malama, Kalonde, primary, Tichacek, Amanda, additional, Kelly, Hilary, additional, Parker, Rachel, additional, Inambao, Mubiana, additional, Sharkey, Tyronza, additional, Wall, Kristin M., additional, Kilembe, William, additional, Price, Matt A., additional, Fast, Pat, additional, Priddy, Fran, additional, and Allen, Susan, additional

Published
2022
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9. Identifying the immune interactions underlying HLA class I disease associations

Author

Debebe, Bisrat J, Boelen, Lies, Lee, James C, IAVI Protocol C Investigators, Thio, Chloe L, Astemborski, Jacquie, Kirk, Gregory, Khakoo, Salim I, Donfield, Sharyne M, Goedert, James J, Asquith, Becca, Sanders, Eduard J, Anzala, Omu, Kamali, Anatoli, Kaleebu, Pontiano, Karita, Etienne, Kilembe, William, Inambao, Mubiana, Lakhi, Shabir, Allen, Susan, Hunter, Eric, Edward, Vinodh A, Fast, Pat E, Price, Matt A, Gilmour, Jill, Tang, Jianming, Asquith, Becca [0000-0002-5911-3160], Apollo - University of Cambridge Repository, and Lee, James [0000-0001-5711-9385]

Subjects
disease association, systems biology, natural killer cell, immunology, HLA, immunogenetics, computational biology, Immunology and Inflammation, CD8 T cell, inflammation, GWAS, Research Article, Computational and Systems Biology, Human
Abstract

Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. HLA class I associations are often interpreted in the light of 'protective' or 'detrimental' CD8+ T cell responses which are restricted by the host HLA class I allotype. However, given the diverse receptors which are bound by HLA class I molecules, alternative interpretations are possible. As well as binding T cell receptors on CD8+ T cells, HLA class I molecules are important ligands for inhibitory and activating killer immunoglobulin-like receptors (KIRs) which are found on natural killer cells and some T cells; for the CD94:NKG2 family of receptors also expressed mainly by NK cells and for leukocyte immunoglobulin-like receptors (LILRs) on myeloid cells. The aim of this study is to develop an immunogenetic approach for identifying and quantifying the relative contribution of different receptor-ligand interactions to a given HLA class I disease association and then to use this approach to investigate the immune interactions underlying HLA class I disease associations in three viral infections: Human T cell Leukemia Virus type 1, Human Immunodeficiency Virus type 1 and Hepatitis C Virus as well as in the inflammatory condition Crohn's disease.

Published
2020

11. Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection

Author

Macharia, Gladys N., primary, Yue, Ling, additional, Staller, Ecco, additional, Dilernia, Dario, additional, Wilkins, Daniel, additional, Song, Heeyah, additional, McGowan, Edward, additional, King, Deborah, additional, Fast, Pat, additional, Imami, Nesrina, additional, Price, Matthew A., additional, Sanders, Eduard J., additional, Hunter, Eric, additional, and Gilmour, Jill, additional

Published
2020
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12. Prevalence and correlates of HIV infection among adolescents and young people living in fishing populations along Lake Victoria Fishing Communities in Uganda

Author

Nanyonjo, Gertrude, primary, Asiki, Gershim, additional, Ssetaala, Ali, additional, Nakaweesa, Teddy, additional, Wambuzi, Mathias, additional, Nanvubya, Annet, additional, Mpendo, Juliet, additional, Okech, Brenda, additional, Kitandwe, Paul Kato, additional, Nielsen, Leslie, additional, Nalutaaya, Annet, additional, Welsh, Sabrina, additional, Bagaya, Bernard Ssentalo, additional, Chinyenze, Kundai, additional, Fast, Pat, additional, Price, Matt, additional, and Kiwanuka, Noah, additional

Published
2020
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13. PS-003: EVIDENCE-INFORMED POLICY MAKING: CHALLENGES AND OPPORTUNITIES

Author

Makanga, Michael, Beattie, Pauline, Breugelmans, Gabrielle, Nyirenda, Thomas, Bockarie, Moses, Tanner, Marcel, Volmink, Jimmy, Hankins, Catherine, Walzl, Gerhard, Chegou, Novel, Malherbe, Stephanus, Hatherill, Mark, Scriba, Thomas J., Zak, Daniel E., Barry, Clifton E., Kaufmann, Stefan H.E., Noor, Abdisalan, Strub-Wourgaft, Nathalie, Phillips, Patrick, Munguambe, Khátia, Ravinetto, Raffaella, Tinto, Halidou, Diro, Ermias, Mahendrahata, Yodi, Okebe, Joseph, Rijal, Suman, Garcia, Coralith, Sundar, Shyam, Ndayisaba, Gilles, Sopheak, Thai, Ngoduc, Thang, Loen, Harry Van, Jacobs, Jan, D'Alessandro, Umberto, Boelaert, Marleen, Buvé, Anne, Kamalo, Patrick, Manda-Taylor, Lucinda, Rennie, Stuart, Mokgatla, Boitumelo, Bahati, Prince, Ijsselmuiden, Carel, Afolabi, Muhammed, Mcgrath, Nuala, Kampmann, Beate, Imoukhuede, Egeruan, Alexander, Neal, Larson, Heidi, Chandramohan, Daniel, Bojang, Kalifa, Kasaro, Margaret Phiri, Muluka, Brenda, Kaunda, Kaunda, Morse, Jill, Westfall, Andrew, Kapata, Nathan, Kruuner, Annika, Henostroza, German, Reid, Stewart, Alabi, Abraham, Foguim, Francis, Sankarganesh, Jeyaraj, Bruske, Ellen, Mfoumbi, Arnault, Mevyann, Chester, Adegnika, Ayola, Lell, Bertrand, Kranzer, Katharina, Kremsner, Peter, Grobusch, Martin, Sabiiti, Wilber, Ntinginya, Nyanda, Kuchaka, Davis, Azam, Khalide, Kampira, Elizabeth, Mtafya, Bariki, Bowness, Ruth, Bhatt, Nilesh, Davies, Gerry, Kibiki, Gibson, Gillespie, Stephen, Lejon, Veerle, Ilboudo, Hamidou, Mumba, Dieudonné, Camara, Mamady, Kaba, Dramane, Lumbala, Crispin, Fèvre, Eric, Jamonneau, Vincent, Bucheton, Bruno, Büscher, Philippe, Chisenga, Caroline, Sinkala, Edford, Chilengi, Roma, Chitundu, Hellen, Zyambo, Zude, Wandeler, Gilles, Vinikoor, Michael, Emilie, Dama, Camara, Oumou, Mathurin, Koffi, Guiguigbaza-Kossigan, Dayo, Philippe, Büscher, Regassa, Fikru, Hassane, Sakande, Bienvenu, Somda Martin, Fabrice, Courtin, Ouédraogo, Elie, Kouakou, Lingue, Owusu, Michael, Mensah, Eric, Enimil, Anthony, Mutocheluh, Mohamed, Ndongo, Francis Ateba, Tejiokem, Mathurin Cyrille, Texier, Gaetan, Penda, Calixte, Ndiang, Suzie, Ndongo, Jean-Audrey, Guemkam, Georgette, Sofeu, Casimir Ledoux, Afumbom, Kfutwa, Faye, Albert, Msellati, Philippe, Warszawski, Josiane, Vos, Alinda, Devillé, Walter, Barth, Roos, Klipstein-Grobusch, Kerstin, Tempelman, Hugo, Venter, François, Coutinho, Roel, Grobbee, Diederick, Ssemwanga, Deogratius, Lyagoba, Frederick, Magambo, Brian, Kapaata, Anne, Kirangwa, Joseph, Nannyonjo, Maria, Nassolo, Faridah, Nsubuga, Rebecca, Yebra, Gonzalo, Brown, Andrew, Kaleebu, Pontiano, Nylén, Hanna, Habtewold, Abiy, Makonnen, Eyasu, Yimer, Getnet, Burhenne, Jürgen, Diczfalusy, Ulf, Aklillu, Eleni, Steele, Duncan, Walker, Richard, Simuyandi, Michelo, Beres, Laura, Bosomprah, Samuel, Ansumana, Rashid, Taitt, C., Lamin, J.M., Jacobsen, K.H., Mulvaney, S.P., Leski, T., Bangura, U., Stenger, D., Vries, Sophie De, Zinsou, Frejus Jeannot, Honkpehedji, J, Dejon, Jean Claude, Loembe, Marguerite Massinga, Bache, Bache, Pakker, Nadine, Leeuwen, Remko Van, Hounkpatin, Aurore Bouyoukou, Yazdanbakhsh, Maria, Bethony, Jeffrey, Hotez, Peter, Diemert, David, Bache, Bache Emmanuel, Fernandes, José F., Mba, Régis M Obiang, Kabwende, Anita L., Grobusch, Martin P., Krishna, Sanjeev, Kremsner, Peter G., Todagbe, Agnandji Selidji, Nambozi, Michael, Kabuya, Jean-Bertin, Hachizovu, Sebastian, Mwakazanga, David, Kasongo, Webster, Buyze, Jozefien, Mulenga, Modest, Geertruyden, Jean-Pierre, Gitaka, Jesse, Chan, Chim, Kongere, James, Kagaya, Wataru, Kaneko, Akira, Kabore, Naomie, Barry, Nouhoun, Kabre, Zachari, Werme, Karidia, Fofana, Aminata, Compaore, Daniel, Nikiema, Frederic, Some, Fabrice, Djimde, Abdoulaye, Zongo, Issaka, Ouedraogo, Bosco, Kone, Aminatou, Sagara, Issaka, Björkman, Anders, Gil, Jose Pedro, Nchinda, Godwin, Bopda, Alain, Nji, Nadesh, Ambada, Georgia, Ngu, Loveline, Tchadji, Jules, Sake, Carol, Magagoum, Suzanne, Njambe, Ghislain D., Lisom, Abel, Park, Chae Gyu, Tait, Dereck, Sibusiso, Hlatjwako, Manda, Olga, Croucher, Kristin, Westhuizen, Anja Van Der, Mshanga, Isaac, Levin, Jonathan, Nanvubya, Annet, Kibengo, Freddie, Jaoko, Walter, Pala, Pietro, Perreau, Matthieu, Namuniina, Annemarie, Kitandwe, Paul, Tapia, Gonzalo, Serwanga, Jennifer, Yates, Nicole, Fast, Pat, Mayer, Bryan, Montefiori, David, Tomaras, Georgia, Robb, Merlin, Lee, Carter, Wagner, Ralf, Sanders, Edward, Kilembe, William, Kiwanuka, Noah, Gilmour, Jill, Kuipers, Hester, Vooij, Dani, Chinyenze, Kundai, Priddy, Frances, Ding, Song, Hanke, Tom, Pantaleo, Giuseppe, Ngasala, Billy, Jovel, Irina, Malmberg, Maja, Mmbando, Bruno, Premji, Zul, Mårtensson, Andreas, Mwaiswelo, Richard, Agbor, Lenshina, Apinjoh, Tobias, Mwanza, Sydney, Chileshe, Justin, Joshi, Sudhaunshu, Malunga, Phidelis, Manyando, Christine, Laufer, Miriam, Dara, Antoine, Niangaly, Amadou, Sinha, Indranil, Brodin, David, Fofana, Bakary, Dama, Souleymane, Dembele, Demba, Sidibe, Bakary, Diallo, Nouhoum, Thera, Mahamadou, Wright, Karin, Gil, Jose, Doumbo, Ogobara, Baraka, Vito, Nabasumba, Carolyn, Francis, Filbert, Lutumba, Pascal, Mavoko, Hypolite, Alifrangis, Michael, Geertruyden, Jean-Pierre Van, Sissoko, Sekou, Sangaré, Cheick, Toure, Sekou, Sanogo, Kassim, Diakite, Hamadoun, Toure, Siaka, Doumbia, Diagassan, Haidara, Kadiatou, Julé, Amélie, Ashurst, Hazel, Merson, Laura, Olliaro, Piero, Marsh, Vicki, Lang, Trudie, Guérin, Philippe, Awuondo, Kennedy, Njenga, Daniel, Nyakarungu, Elizabeth, Titus, Pauline, Sutamihardja, Awalludin, Lowe, Brett, Ogutu, Bernhards, Billingsley, Peter, Soulama, Issiaka, Kaboré, Moïse, Coulibaly, Aboubacar, Ouattara, Maurice, Sanon, Souleymane, Diarra, Amidou, Bougouma, Edith, Ouedraogo, Alphonse, Sombie, Benjamin, Ouedraogo, Amidou, Kargougou, Désiré, Ouattara, Daouda, Issa, Nebie, Tiono, Alfred, Sirima, Sodiomon, Chaponda, Mike, Dabira, Edgard, Dao, François, Dara, Nianwalou, Sidibe, Bouran, Coulibaly, Moctar, Tolo, Allaye, Maiga, Hamma, Ouologuem, Nouhoum, Niangaly, Hamidou, Botchway, Felix, Wilson, Nana, Dickinson-Copeland, Carmen M, Adjei, Andrew A., Wilson, Michael, Stiles, Jonathan K., Hamid, Muzamil Abdel, Awad-Elgeid, Mona, Nasr, Awad, Netongo, Palmer, Kamdem, Séverin, Velavan, Thirumalaisamy, Lasry, Estrella, Diarra, Modibo, Bamadio, Amadou, Traore, Aliou, Coumare, Samba, Soma, Bahonan, Dicko, Yeyia, Sangare, Boubou, Tembely, Aly, Traore, Djibril, Haidara, Aboubecrin, Dicko, Alassane, Diawara, Elisabeth, Beavogui, Abdoul, Camara, Daouda, Sylla, Malick, Yattara, Mohamed, Sow, Amadou, Camara, Gnèpou Camara, Diallo, Saliou, Mombo-Ngoma, Ghyslain, Remppis, Jonathan, Sievers, Moritz, Manego, Rella Zoleko, Endamne, Lilian, Hutchinson, David, Held, Jana, Supan, Christian, Salazar, Carmen L. Ospina, Bonkian, Léa Nadège, Nahum, Alain, Sié, Ali, Abdulla, Salim, Cantalloube, Cathy, Djeriou, Elhadj, Bouyou-Akotet, Marielle, Mordmüller, Benjamin, Siribie, Mohamadou, Sirima, Sodiomon B., Ouattara, San Maurice, Coulibaly, Sam, Kabore, Jean Moïse, Amidou, Diarra, Tekete, Mamadou, Burhenne, Juergen, Traore, Oumar, Haefeli, Walter, Borrmann, Steffen, Kaboré, Naomie, Kabré, Zachari, Nikèma, Fréderic, Compaoré, Daniel, Somé, Fabrice, Djimdé, Abdoulaye, Ouédraogo, Jean, Chalwe, Victor, Miller, John, Diakité, Hamadoun, Greco, Beatrice, Spangenberg, Thomas, Kourany-Lefoll, Elly, Oeuvray, Claude, Mulry, Jim, Tyagarajan, Kamala, Magsaam, Bettina, Barnes, Karen, Hodel, Eva Maria, Humphreys, Georgina, Pace, Cheryl, Banda, C.G, Denti, Paulo, Allen, Elizabeth, Lalloo, David, Mwapasa, Victor, Terlouw, Anja, Mwesigwa, Julia, Achan, Jane, Jawara, Musa, Ditanna, Gian, Worwui, Archibald, Affara, Muna, Koukouikila-Koussounda, Félix, Kombo, Michael, Vouvoungui, Christevy, Ntoumi, Francine, Etoka-Beka, Mandingha Kosso, Deibert, Julia, Poulain, Pierre, Kobawila, Simon, Gueye, Nerly Gampio, Koukouikila-Koussounda, Felix, Seda, Brian, Kwambai, Titus, Jangu, Phelix, Samuels, Aaron, ter Kuile, Feike, Kariuki, Simon, Barry, Aissata, Bousema, Teun, Okech, Brenda, Egwang, Thomas, Corran, Patrick, Riley, Eleanor, Ezennia, Ifeoma, Ekwunife, Obinna, Muleba, Mbanga, Stevenson, Jennifer, Mbata, Keith, Coetzee, Maureen, Norris, Douglas, Moneke-Anyanwoke, Ngozi, Momodou, Jasseh, Clarke, Ed, Scott, Susana, Tijani, Adelani, Djimde, Moussa, Vaillant, Michel, Samouda, Hanen, Mensah, Victorine, Roetynck, Sophie, Kanteh, Ebrima, Bowyer, Georgina, Ndaw, Amy, Oko, Francis, Bliss, Carly, Jagne, Ya Jankey, Cortese, Riccardo, Nicosia, Alfredo, Roberts, Rachel, D'Alessio, Flavia, Leroy, Odile, Faye, Babacar, Cisse, Badara, Gerry, Stephen, Viebig, Nicola, Lawrie, Alison, Ewer, Katie, Hill, Adrian, Nebie, Issa, Tiono, Alfred B, Sanou, Guillaume, Konate, Amadou T, Yaro, Baptiste J, Sodiomon, Sirima, Honkpehedji, Yabo, Agobe, Jean Claude Dejon, Zinsou, Frejus, Mengue, Juliana, Richie, Thomas, Hoffman, Stephen, Nouatin, Odilon, Ngoa, Ulysse Ateba, Edoa, Jean R, Homoet, Andreas, Engelhon, Julie Englhon, Massinga-Louembe, Marguerite, Esen, Meral, Theisen, Michael, Sim, Kim Lee, Luty, Adrian Jf, Moutairou, Kabirou, Dinko, Bismarck, King, Elizabeth, Targett, Geoffrey, Sutherland, Colin, Likhovole, Clement, Ouma, Collins, Vulule, John, Musau, Susan, Khayumbi, Jeremiah, Okumu, Albert, Murithi, Wilfred, Otu, Jacob, Gehre, Florian, Zingue, Dezemon, Kudzawu, Samuel, Forson, Audrey, Mane, Morto, Rabna, Paulo, Diarra, Bassirou, Kayede, Salako, Adebiyi, Emmanuel, Kehinde, Aderemi, Onyejepu, Nneka, Onubogu, Catherine, Idigbe, Emmanuel, Ba, Awa, Diallo, Aissatou, Mboup, Souleymane, Disse, Kodjo, Kadanga, Gerard, Dagnra, Yaotse, Baldeh, Ignatius, Corrah, Tumani, Jong, Bouke De, Antonio, Martin, Musanabaganwa, Clarisse, Musabyimana, Jean Pierre, Karita, Etienne, Diop, Blondin, Nambajimana, Abidan, Dushimiyimana, Valentine, Karame, Prosper, Russell, Jim, Ndoli, Jules, Hategekimana, Theobald, Sendegeya, Augustin, Condo, Jeannine, Binagwaho, Agnes, Okonko, Iheanyi, Okerentugba, Phillip, Opaleye, Oluyinka, Awujo, Ezinwanne, Frank-Peterside, Nnenna, Moyo, Sikhulile, Kotokwe, Kenanao, Mohammed, Terence, Boleo, Coretah, Mupfumi, Lucy, Chishala, Samuel, Gaseitsiwe, Simani, Tsalaile, Lesedi, Bussmann, Herman, Makhema, Joseph, Baum, Marianna, Marlink, Richard, Engelbretch, Susan, Essex, Max, Novitsky, Vladimir, Saka, Emmanuel, Kalipalire, Zex, Bhairavabhotla, Ravikiran, Midiani, Dalitso, Sherman, Judith, Mgode, Georgies, Cox, Christophe, Bwana, Dickens, Mtui, Leah, Magesa, Daniel, Kahwa, Amos, Mfinanga, Godfrey, Mulder, Christiaan, Borain, Nick, Petersen, Lizette, Plessis, Julianne Du, Theron, Grant, Holm-Hansen, Carol, Tekwu, Emmanuel Mouafo, Sidze, Larissa Kamgue, Assam, Jean Paul Assam, Eyangoh, Sarah, Niemann, Stefan, Beng, Veronique Penlap, Frank, Matthias, Atiadeve, Samuel, Hilmann, Doris, Awoniyi, Dolapo, Baumann, Ralf, Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre, Kaempfer, Susanne, Singh, Mahavir, Mwanza, Winnie, Milimo, Deborah, Moyo, Maureen, Kasese, Nkatya, Cheeba-Lengwe, Maina, Munkondya, Stembiso, Ayles, Helen, Haas, Petra De, Muyoyeta, Monde, Namuganga, Anna Ritah, Kizza, Harriet Mayanja, Mendy, Alieu, Tientcheu, Leopold, Ayorinde, Abigail, Coker, Edward, Egere, Uzochukwu, Coussens, Anna, Naude, Celeste, Chaplin, George, Noursadeghi, Mahdad, Martineau, Adrian, Jablonski, Nina, Wilkinson, Robert, Ouedraogo, Henri Gautier, Matteelli, Alberto, Regazzi, Mario, Tarnagda, Grissoum, Villani, Paola, Sulis, Giorgia, Diagbouga, Serge, Roggi, Alberto, Giorgetti, Francesco, Kouanda, Seni, Bidias, Amel, Ndjonka, Dieudonné, Olemba, Clémence, Souleymanou, Arabo, Mukonzo, Jackson, Kuteesa, Ronald, Ogwal-Okeng, Jasper, Gustafsson, Lars L., Owen, Joel, Bassi, Peter, Gashau, Wadzani, Olaf, Klungel, Dodoo, Alexander, Okonkwo, Prosper, Kanki, Phyllis, Maruapula, Dorcas, Seraise, Boitumelo, Einkauf, Kevin, Reilly, Amanda, Rowley, Christopher, Musonda, Rosemary, Framhein, Anna, Mpagama, Stella, Semvua, Hadija, Maboko, Leonard, Hoelscher, Michael, Heinrich, Norbert, Mulenga, Lloyd, Kaayunga, Callistus, Davies, Mary-Ann, Egger, Matthias, Musukuma, Kalo, Dambe, Rosalia, Usadi, Benjamin, Ngari, Moses, Thitiri, Johnstone, Mwalekwa, Laura, Fegan, Greg, Berkley, James, Nsagha, Dickson, Munamunungu, Virginia, Bolton, Carolyn, Siyunda, Alice, Shilimi, Jacinta, Bucciardini, Raffaella, Fragola, Vincenzo, Abegaz, Teshome, Lucattini, Stefano, Halifom, Atakilt, Tadesse, Eskedar, Berhe, Micheal, Pugliese, Katherina, Castro, Paola De, Terlizzi, Roberta, Fucili, Luca, Gregorio, Massimiliano Di, Mirra, Marco, Zegeye, Teame, Binelli, Andrea, Vella, Stefano, Abraham, Loko, Godefay, Hagos, Rakotoarivelo, Rivo, Raberahona, Mihaja, Randriamampionona, Njary, Andriamihaja, Rabezanahary, Rasamoelina, Tahinamandranto, Cornet, Muriel, Randria, Mamy Jean De Dieu, Benet, Thomas, Vanhems, Philippe, Andrianarivelo, Mala Rakoto, Chirwa, Uchizi, Michelo, Charles, Hamoonga, Raymond, Wandiga, Steve, Oduor, Patience, Agaya, Janet, Sharma, Aditya, Cavanaugh, Sean, Cain, Kevin, Mukisa, John, Mupere, Ezekiel, Worodria, William, Ngom, Justice Trésor, Koro, Francioli, Godwe, Celestin, Adande, Clemence, Ateugieu, Romaric, Onana, Tatiana, Ngono, Annie, Kamdem, Yannick, Ngo-Niobe, Sara, Etoa, François-Xavier, Kanengoni, Muchineripi, Ruzario, Sithembile, Ndebele, Paul, Shana, Melody, Tarumbiswa, Fadzai, Musesengwa, Rosemary, Gutsire, Rutendo, Fisher, Kevin, Thyagarajan, Bargavi, Akanbi, Olusola, Binuyo, Michael, Ssengooba, Willy, Respeito, Durval, Mambuque, Edson, Blanco, Silvia, Mandomando, Inacio, Cobelens, Frank, Garcia-Basteiro, Alberto, Tamene, Ayele, Topp, Stephanie, Mwamba, Chanda, Padian, Nancy, Sikazwe, Izukanji, Geng, Elvin, Holmes, Charles, Sikombe, Kombatende, Hantuba, Cardinal, Czaicki, Nancy, Simbeza, Sandra, Somwe, Paul, Umulisa, Michele, Ilo, Jennifer, Kestelyn, Evelyne, Uwineza, Mireille, Agaba, Stephen, Delvaux, Therese, Wijgert, Janneke, Gethi, Dickson, Odeny, Lazarus, Tamandjou, Cynthia, Kaindjee-Tjituka, Francina, Brandt, Laura, Cotton, Mark, Nel, Etienne, Preiser, Wolfgang, Andersson, Monique, Adepoju, Abiola, Magana, Musa, Etsetowaghan, Andrew, Chilikwazi, Mutinta, Sutcliffe, Catherine, Thuma, Philip, Sinywimaanzi, Kathy, Matakala, Hellen, Munachoonga, Passwell, Moss, William, Masenza, Issa Sabi, Geisenberger, Otto, Agrea, Peter, Rwegoshora, France, Mahiga, Hellen, Olomi, Willyhelmina, Kroidl, Arne, Kayode, Gbenga, Amoakoh-Coleman, Mary, Ansah, Evelyn, Uthman, Olalekan, Fokam, Joseph, Santoro, Maria-Mercedes, Musolo, Chrissie, Chimbiri, Isabel, Chikwenga, Gloria, Deula, Ruth, Massari, Riccardo, Lungu, Agness, Perno, Carlo-Federico, Ndzengue, Georgia, Loveline, Ngu, Lissom, Abel, Flaurent, Tchouangueu, Sosso, Samuel, Essomba, Claudine, Kpeli, Grace, Otchere, Isaac, Lamelas, Araceli, Buultjens, Andrew, Bulach, Dieter, Baines, Sarah, Seemann, Torsten, Giulieri, Stefano, Nakobu, Zuliehatu, Aboagye, Samuel, Owusu-Mireku, Evelyn, Danso, Emelia, Hauser, Julia, Hinic, Vladimira, Pluschke, Gerd, Stinear, Timothy, Yeboah-Manu, Dorothy, Elshayeb, Ayman, Siddig, Marmar El, Ahmed, Abdel Azim, Hussien, Adil El, Kabwe, Mwila, Tembo, John, Chilukutu, Lophina, Chilufya, Moses, Ngulube, Francis, Lukwesa, Chileshe, Enne, Virve, Wexner, Hannah, Mwananyanda, Lawrence, Hamer, Davidson, Sinyangwe, Sylvester, Ahmed, Yusuf, Klein, Nigel, Maeurer, Markus, Zumla, Ali, Bates, Matthew, Beyala, Landry, Etienne, Guenou, Anthony, Njimbia, Benjamin, Azike, Ateudjieu, Jerome, Chibwe, Bertha, Ojok, David, Tarr, Christine Attia, Perez, Guillermo Martinez, Omeonga, Senga, Kibungu, Fanta, Meyer, Ana, Lansana, Peter, Mayor, Alfredo, Onyango, Peter, Loggerenberg, François Van, Furtado, Tamzin, Boggs, Liam, Segrt, Alexis, Dochez, Carine, Burnett, Rosemary, Mphahlele, M. Jeffrey, Miiro, George, Mbidde, Edward, Peshu, Norbert, Kivaya, Esther, Ngowi, Bernard, Kavishe, Reginald, Maowia, Mukhtar, Sandstrom, Eric, Ayuo, Elizabeth, Mmbaga, Blandina, Leisegang, Cordelia, Thorpe, Marie, Batchilly, Elizabeth, N'Guessan, Jean-Pierre, Kanteh, Dembo, Søfteland, Solrun, Sebitloane, Motshedisi, Vwalika, Bellington, Taylor, Myra, Galappaththi-Arachchige, Hashini, Holmen, Sigve, Gundersen, Svein Gunnar, Ndhlovu, Patricia, Kjetland, Eyrun Floerecke, Kombe, Francis, Toohey, Jacintha, Pienaar, Elizabeth, Kredo, Tamara, Cham, Pa Modou, Abubakar, Ismaela, Dondeh, Bai Lamin, Vischer, Nerina, Pfeiffer, Constanze, Burri, Christian, Musukwa, Kalo, Zürcher, Samuel, Mwandu, Temwani, Bauer, Sophie, Adriko, Moses, Mwaura, Peter, Omolloh, Kevin, Jones, Clarer, Malecela, Mwelecele, Hamidu, Buhari Adamu, Jenner, Tettevi Edward, Asiedu, Larbi John, Osei-Atweneboana, Mike, Afeke, Innocent, Addo, Phyllis, Newman, Mercy, Durnez, Lies, Eddyani, Miriam, Ammisah, Nana, Abas, Mona, Quartey, Maxwell, Ablordey, Anthony, Akinwale, Olaoluwa, Adeneye, Adeniyi, Ezeugwu, Sylvanus, Olukosi, Yetunde, Adewale, Babatunde, Sulyman, Medinat, Mafe, Margaret, Okwuzu, Jane, Gyang, Pam, Nwafor, Timothy, Henry, Uzoma, Musa, Bilkisu, Ujah, Innocent, Agobé, Jean Claude Dejon, Grau-Pujol, Berta, Sacoor, Charfudin, Nhabomba, Augusto, Casellas, Aina, Quintó, Llorenç, Subirà, Carme, Giné, Ricard, Valentín, Antònia, Muñoz, Jose, Nikiema, Marguerite, Ky-Ba, Absatou, Comapore, Kiswendsida Abdou Muller, Traore, Alfred, Sangare, Lassana, Oluremi, Adeolu, Michel, Mandro, Camara, Yaya, Sanneh, Bakary, Cuamba, Inocencia, Gutiérrez, Jose, Lázaro, Carlota, Mejia, Rojelio, Adedeji, Abimbola, Folorunsho, Sola, Demehin, Pelumi, Akinsanya, Bamidele, Cowley, Giovanna, Silva, Eunice Teixeira Da, Nabicassa, Meno, Barros, Pedrozinho Duarte Pereira De, Blif, Milena Mbote, Bailey, Robin, Last, Anna, Mahendradhata, Yodi, Gotuzzo, Eduardo, Nys, Kateljine De, Casteels, Minnes, Nona, Sylvie Kwedi, Lumeka, Kabwende, Todagbe, Agnandji, Djima, Mariam Mama, Ukpong, Morenike, Sagay, Atiene, Khamofu, Hadiza, Torpey, Kwasi, Afiadigwe, Evaristus, Anenih, James, Ezechi, Oliver, Nweneka, Chidi, Idoko, John, Muhumuza, Simon, Katahoire, Anne, Nuwaha, Fred, Olsen, Annette, Okeyo, Seth, Omollo, Raymond, Kimutai, Robert, Ochieng, Michael, Egondi, Thaddaeus, Moonga, Clement, Chileshe, Chisele, Magwende, George, Anumudu, Chiaka, Onile, Olugbenga, Oladele, Victoria, Adebayo, Adewale, Awobode, Henrietta, Oyeyemi, Oyetunde, Odaibo, Alexander, Kabuye, Emily, Lutalo, Tom, Njua-Yafi, Clarisse, Nkuo-Akenji, Theresa, Anchang-Kimbi, Judith, Mugri, Regina, Chi, Hanesh, Tata, Rolland, Njumkeng, Charles, Dodoo, Daniel, Achidi, Eric, Fernandes, José, Bache, Emmanuel B., Matakala, Kalumbu, Searle, Kelly, Greenman, Michelle, and Rainwater-Lovett, Kaitlin

Subjects
Abstracts of Poster Presentations, Abstracts of Oral Presentations, Author Index, Abstracts of Presentations in Plenary Sessions, Article, Abstracts of the Eighth Edctp Forum, 6–9 November 2016
Published
2017

15. THE RESULTS OF THE EV06 DNA-PROTEIN COMBINATION TRIAL AND PLANS FOR GREAT, AN EDCTP2-FUNDED CONSERVED-MOSAIC EPITOPE HIV VACCINE TRIAL

Author

Kaleebu, Pontiano, Levin, Jonathan, Nanvubya, Annet, Kibengo, Freddie, Jaoko, Walter, Pala, Pietro, Perreau, Matthieu, Namuniina, Annemarie, Kitandwe, Paul, Tapia, Gonzalo, Serwanga, Jennifer, Yates, Nicole, Fast, Pat, Mayer, Bryan, Montefiori, David, Tomaras, Georgia, Robb, Merlin, Lee, Carter, Wagner, Ralf, Sanders, Edward, Kilembe, William, Kiwanuka, Noah, Gilmour, Jill, Kuipers, Hester, Vooij, Dani, Chinyenze, Kundai, Priddy, Frances, Ding, Song, Hanke, Tom, and Pantaleo, Giuseppe

Published
2017

16. Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection.

Author

Macharia, Gladys N., Yue, Ling, Staller, Ecco, Dilernia, Dario, Wilkins, Daniel, Song, Heeyah, McGowan, Edward, King, Deborah, Fast, Pat, Imami, Nesrina, Price, Matthew A., Sanders, Eduard J., Hunter, Eric, and Gilmour, Jill

Subjects
T cells, HIV infections, VIRUS diseases, MOLECULAR cloning, INFECTION, B cells
Abstract

HIV-1 transmission is associated with a severe bottleneck in which a limited number of variants from a pool of genetically diverse quasispecies establishes infection. The IAVI protocol C cohort of discordant couples, female sex workers, other heterosexuals and men who have sex with men (MSM) present varying risks of HIV infection, diverse HIV-1 subtypes and represent a unique opportunity to characterize transmitted/founder viruses (TF) where disease outcome is known. To identify the TF, the HIV-1 repertoire of 38 MSM participants' samples was sequenced close to transmission (median 21 days post infection, IQR 18–41) and assessment of multivariant infection done. Patient derived gag genes were cloned into an NL4.3 provirus to generate chimeric viruses which were characterized for replicative capacity (RC). Finally, an evaluation of how the TF virus predicted disease progression and modified the immune response at both acute and chronic HIV-1 infection was done. There was higher prevalence of multivariant infection compared with previously described heterosexual cohorts. A link was identified between multivariant infection and replicative capacity conferred by gag, whereby TF gag tended to be of lower replicative capacity in multivariant infection (p = 0.02) suggesting an overall lowering of fitness requirements during infection with multiple variants. Notwithstanding, multivariant infection was associated with rapid CD4+ T cell decline and perturbances in the CD4+ T cell and B cell compartments compared to single variant infection, which were reversible upon control of viremia. Strategies aimed at identifying and mitigating multivariant infection could contribute toward improving HIV-1 prognosis and this may involve strategies that tighten the stringency of the transmission bottleneck such as treatment of STI. Furthermore, the sequences and chimeric viruses help with TF based experimental vaccine immunogen design and can be used in functional assays to probe effective immune responses against TF. Author summary: The development of a safe and effective HIV-1 vaccine alongside cure strategies is a major public health concern and requires in-depth knowledge of the HIV-1 populations that establish infection. Here we sequenced the HIV genetic populations present during the acute stage of HIV-1 infection in 38 Men who have sex with men (MSM) and identified the transmitted/founder variant's sequence. We then cloned the gag gene from each patient's transmitted/founder gag sequences in both single and multiple variant infection into a common, lab-adapted virus and measured the replicative capacity it conferred on this virus. Finally, cellular immune responses were compared between single variant and multiple variant infection at 0–3, 6–9 and 24–30 months after infection. We observed a higher frequency of multivariant infection in MSM than has been previously described in heterosexually infected participants, and this was associated with faster decline of CD4+ T cells and perturbances in the CD4+ T cell and the B cell compartment. Moreover, the replicative capacity conferred by gag was lower in multivariant infection, suggesting a less stringent transmission bottleneck that allowed for less fit variants to establish infection. These results suggest that strategies to tighten the stringency of the transmission bottleneck may be of benefit to patients by reducing the likelihood of multivariant transmission and potentially slowing down disease progression. [ABSTRACT FROM AUTHOR]

Published
2020
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17. Understanding mobility and sexual risk behaviour among women in fishing communities of Lake Victoria in East Africa: a qualitative study.

Author

Kwena, Zachary, Nakamanya, Sarah, Nanyonjo, Gertrude, Okello, Elialilia, Fast, Pat, Ssetaala, Ali, Oketch, Bertha, Price, Matt, Kapiga, Saidi, Bukusi, Elizabeth, Seeley, Janet, the LVCHR, Grosskurth, Heiner, Kamali, Anatoli, Kaleebu, Pontiano, Kibengo, Freddie Mukasa, Kidega, William, De Bont, Jan, and LVCHR

Subjects
FISHING villages, HIV prevention, HIV infections, WOMEN'S sexual behavior, WOMEN
Abstract

Background: HIV-prevalence and incidence is high in many fishing communities around Lake Victoria in East Africa. In these settings, mobility among women is high and may contribute to increased risk of HIV infection and poor access to effective prevention and treatment services. Understanding the nature and patterns of this mobility is important for the design of interventions. We conducted an exploratory study to understand the nature and patterns of women's mobility to inform the design of HIV intervention trials in fishing communities of Lake Victoria.Methods: This was a cross-sectional formative qualitative study conducted in six purposively selected fishing communities in Kenya, Tanzania and Uganda. Potential participants were screened for eligibility on age (18+ years) and having stayed in the fishing community for more than 6 months. We collected data using introductory and focus group discussions, and in-depth interviews with key informants. Data focused on: history and patterns of mobility, migration in and out of fishing communities and the relationship between mobility and HIV infection. Since the interviews and discussions were not audio-recorded, detailed notes were taken and written up into full scripts for analysis. We conducted a thematic analysis using constant comparison analysis.Results: Participants reported that women in fishing communities were highly mobile for work-related activities. Overall, we categorized mobility as travels over long and short distances or periods depending on the kind of livelihood activity women were involved in. Participants reported that women often travelled to new places, away from familiar contacts and far from healthcare access. Some women were reported to engage in high risk sexual behaviour and disengaging from HIV care. However, participants reported that women often returned to the fishing communities they considered home, or followed a seasonal pattern of work, which would facilitate contact with service providers.Conclusion: Women exhibited circular and seasonal mobility patterns over varying distances and duration away from their home communities. These mobility patterns may limit women's access to trial/health services and put them at risk of HIV-infection. Interventions should be tailored to take into account mobility patterns of seasonal work observed in this study. [ABSTRACT FROM AUTHOR]

Published
2020
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19. Assessment of Anti–HIV-1 Antibodies in Oral and Nasal Compartments of Volunteers From 3 Different Populations

Author

Bergin, Philip J., primary, Langat, Robert, additional, Omosa-Manyonyi, Gloria, additional, Farah, Bashir, additional, Ouattara, Gina, additional, Park, Harriet, additional, Coutinho, Helen, additional, Laufer, Dagna, additional, Fast, Pat, additional, Verlinde, Carl, additional, Bizimana, Jean, additional, Umviligihozo, Gisele, additional, Nyombayire, Julien, additional, Ingabire, Rosine, additional, Kuldanek, Kristin, additional, Cox, Josephine, additional, McMorrow, Martin, additional, Fidler, Sarah, additional, Karita, Etienne, additional, Gilmour, Jill, additional, and Anzala, Omu, additional

Published
2016
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20. Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch

Author

MacLeod, Daniel T., primary, Choi, Nancy M., additional, Briney, Bryan, additional, Garces, Fernando, additional, Ver, Lorena S., additional, Landais, Elise, additional, Murrell, Ben, additional, Wrin, Terri, additional, Kilembe, William, additional, Liang, Chi-Hui, additional, Ramos, Alejandra, additional, Bian, Chaoran B., additional, Wickramasinghe, Lalinda, additional, Kong, Leopold, additional, Eren, Kemal, additional, Wu, Chung-Yi, additional, Wong, Chi-Huey, additional, Kosakovsky Pond, Sergei L., additional, Wilson, Ian A., additional, Burton, Dennis R., additional, Poignard, Pascal, additional, Price, Matt A., additional, Gilmour, Jill, additional, Fast, Pat, additional, Kamali, Anatoli, additional, Sanders, Eduard J., additional, Anzala, Omu, additional, Allen, Susan, additional, Hunter, Eric, additional, Karita, Etienne, additional, Lakhi, Shabir, additional, Inambao, Mubiana, additional, Edward, Vinodh, additional, and Bekker, Linda-Gail, additional

Published
2016
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21. Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein

Author

Zhang, Xinsheng, primary, Wallace, Olivia L., additional, Domi, Arban, additional, Wright, Kevin J., additional, Driscoll, Jonathan, additional, Anzala, Omu, additional, Sanders, Eduard J., additional, Kamali, Anatoli, additional, Karita, Etienne, additional, Allen, Susan, additional, Fast, Pat, additional, Gilmour, Jill, additional, Price, Matt A., additional, and Parks, Christopher L., additional

Published
2015
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22. The Immune Space: A Concept and Template for Rationalizing Vaccine Development

Author

Manrique, Amapola, primary, Adams, Elizabeth, additional, Barouch, Dan H., additional, Fast, Pat, additional, Graham, Barney S., additional, Kim, Jerome H., additional, Kublin, James G., additional, McCluskey, Margaret, additional, Pantaleo, Giuseppe, additional, Robinson, Harriet L., additional, Russell, Nina, additional, Snow, William, additional, and Johnston, Margaret I., additional

Published
2014
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23. Acceptability and Feasibility of Repeated Mucosal Specimen Collection in Clinical Trial Participants in Kenya

Author

Omosa-Manyonyi, Gloria, primary, Park, Harriet, additional, Mutua, Gaudensia, additional, Farah, Bashir, additional, Bergin, Philip J., additional, Laufer, Dagna, additional, Lehrman, Jennifer, additional, Chinyenze, Kundai, additional, Barin, Burc, additional, Fast, Pat, additional, Gilmour, Jill, additional, and Anzala, Omu, additional

Published
2014
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25. African Early Infection Cohort as a Platform for Vaccine Discovery: The IAVI Protocol C Experience

Author

Gilmour, Jill, primary, Kamali, Anatoli, additional, Karita, Etienne, additional, Kilembe, William, additional, Sanders, Eduard J., additional, Anzala, Omu, additional, Allen, Susan, additional, Edward, Vinodh, additional, Priddy, Fran, additional, Price, Matt A., additional, Macharia, Gladys, additional, Baalwa, Joshua, additional, Crotty, Shane, additional, Denny, Thomas, additional, Landais, Elise, additional, Borrow, Persephone, additional, Tang, Jianming, additional, Busch, Michael, additional, Prince, Jessica, additional, Claiborne, Dan, additional, Poignard, Pascal, additional, Fast, Pat, additional, and Hunter, Eric, additional

Published
2014
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26. Implementation of a Training Program to Standardize Mucosal Sample Collection and Processing at Multiple Laboratories in Eastern Africa

Author

Omosa-Manyonyi, Gloria, primary, Langat, Robert, additional, Mutisya, Elizabeth, additional, Park, Harriet, additional, Bergin, Philip, additional, Farah, Bashir, additional, Ogutu, Hilda, additional, Ogola, Simon, additional, Ouattara, Gina, additional, Indangasi, Jackton, additional, Ndambuki, Rose, additional, Fast, Pat, additional, Laufer, Dagna, additional, Priddy, Fran, additional, and Anzala, Omu, additional

Published
2014
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30. Prevalence of HIV, Sexual Transmitted Infections and High Risk Sexual Behaviors among Female Sex Workers in Kigali, Rwanda

Author

Mukamuyango, Jeannine, primary, Ingabire, Rosine, additional, Karita, Etienne, additional, Nyombayire, Julien, additional, Sinabamenye, Robertine, additional, Ahmed, Nuri, additional, Nduwamungu, Jean Nepo, additional, Radjabari, Sukaina, additional, Oppert, Marydale, additional, Price, Matt, additional, Priddy, Frances, additional, Fast, Pat, additional, Tichacek, Amanda, additional, and Allen, Susan, additional

Published
2014
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31. Detection of Vaccine Induced Mucosal Antibodies in Phase I HIV Preventative Vaccine Trials

Author

Bergin, Phil, primary, Langat, Robert, additional, Farah, Bashir, additional, Ogola, Simon, additional, Omosa-Manyonyi, Gloria, additional, Mutua, Gaudensia, additional, Outtara, Gina, additional, Park, Harriet, additional, Lehrman, Jennifer, additional, Mwangi, Irene, additional, Coutinho, Helen, additional, Chetty, Paramesh, additional, McMorrow, Martin, additional, Cox, Josephine, additional, Fast, Pat, additional, Laufer, Dagna, additional, Gilmour, Jill, additional, and Anzala, Omu, additional

Published
2014
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32. Overweight BMI and Alcohol Use Are Associated with Immune Responses in Phase I HIV Vaccine Trials

Author

Bayingana, Roger, primary, Mutua, Gaudensia, additional, Mpendo, Juliet, additional, Kilembe, William, additional, Omosa-Manyonyi, Gloria, additional, Ruzagirwa, Eugene, additional, Page-Shipp, Liesl, additional, Gray, Glenda, additional, Bekker, Linda-Gail, additional, Baden, Lindsey, additional, Hayes, Peter, additional, Dally, Len, additional, Schmidt, Claudia, additional, Laufer, Dagna, additional, Priddy, Frances, additional, Fast, Pat, additional, Gilmour, Jill, additional, and Cox, Josephine, additional

Published
2014
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34. High Transmitter CD4+ T-Cell Count Shortly after the Time of Transmission in a Study of African Serodiscordant Couples.

Author

Karita, Etienne, Price, Matt A, Lakhi, Shabir, Kilembe, William, Kamali, Anatoli, Ruzagira, Eugene, Hunter, Eric, Farmer, Paul, Allen, Susan, Stevens, Gwynn, Chetty, Paramesh, Welsh, Sabrina, Yang, Annie, Gilmour, Jill, Fast, Pat, and null, null

Subjects
HIV infection transmission, CD4 antigen, T cells, AFRICANS, LONGITUDINAL method, DISEASES
Abstract

Background: 2013 WHO guidelines recommend starting ART at CD4+ T-cell counts ≤500 cells/μL. We present the T-cell counts from adult Africans with HIV shortly following transmission to their sexual partners. Methods: HIV-discordant couples in Zambia, Uganda and Rwanda were followed prospectively and received couples counseling and condoms. HIV uninfected partners were tested for HIV at least quarterly and HIV-infected partners received HIV care and referral for ART per national guidelines. Upon diagnosis of incident HIV infection in the previously HIV-uninfected partner, a blood sample was collected from both partners to measure CD4+ T-cells and perform viral linkage. The estimated date of infection (EDI) of the incident case was calculated based on testing history. EDI was unknown for suspected transmitting partners. Results: From 2006–2011, 4,705 HIV-discordant couples were enrolled in this cohort, and 443 cases of incident HIV infection were documented. Virus linkage analysis was performed in 374 transmission pairs, and 273 (73%) transmissions were linked genetically. CD4 counts in the transmitting partner were measured a median of 56 days after EDI (mean:90.5, min:10, max:396). The median CD4 count was 339 cells/μl (mean:386.4, min:15, max:1,434), and the proportion of partners with a CD4+ T-cell count above 500/μl was 25% (95% CI:21, 31). Conclusions: In our cohort of discordant couples, 73% of HIV transmissions occurred within the relationship, and the transmitter CD4+ T cell count shortly after the transmission event was frequently higher than the WHO 2013 ART-initiation guidelines. [ABSTRACT FROM AUTHOR]

Published
2015
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35. Overweight BMI and Alcohol Use Are Associated with Immune Responses in Phase I HIV Vaccine Trials.

Author

Mutua, Gaudensia, Mpendo, Juliet, Kilembe, William, Omosa-Manyonyi, Gloria, Ruzagirwa, Eugene, Page-Shipp, Liesl, Gray, Glenda, Bekker, Linda-Gail, Baden, Lindsey, Hayes, Peter, Dally, Len, Schmidt, Claudia, Laufer, Dagna, Priddy, Frances, Fast, Pat, Gilmour, Jill, and Cox, Josephine

Abstract

An abstract of the article "Overweight BMI and Alcohol Use Are Associated with Immune Responses in Phase I HIV Vaccine Trials" by Gaudensia Mutua, Juliet Mpendo and colleagues is presented.

Published
2014
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36. Participation in Clinical Research Could Modify Background Risk for Trial Outcome Measures.

Author

Asiki, Gershim, Levin, Jonathan, Bahemuka, Ubaldo, Ruzagira, Eugene, Kibengo, Freddie M., Mulondo, Jerry, Ndibazza, Juliet, Price, Matthew A., Fast, Pat, and Kamali, Anatoli

Abstract

An abstract of the article "Participation in Clinical Research Could Modify Background Risk for Trial Outcome Measures" by Andrew M. Abaasa, Gershim Asiki, Jonathan Levin, Ubaldo Bahemuka and colleagues is presented.

Published
2014
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37. Implementation of a Training Program to Standardize Mucosal Sample Collection and Processing at Multiple Laboratories in Eastern Africa.

Author

Langat, Robert, Mutisya, Elizabeth, Park, Harriet, Bergin, Philip, Farah, Bashir, Ogutu, Hilda, Ogola, Simon, Ouattara, Gina, Indangasi, Jackton, Ndambuki, Rose, Fast, Pat, Laufer, Dagna, Priddy, Fran, and Anzala, Omu

Abstract

An abstract of the article "Implementation of a Training Program to Standardize Mucosal Sample Collection and Processing at Multiple Laboratories in Eastern Africa" by Robert Langat, Elizabeth Mutisya, Harriet Park and colleagues is presented.

Published
2014
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38. Use of Virtual Cohorts in Zambia's Couples' Voluntary Counseling and Testing (CVCT) as a Screening Mechanism for Clinical Trials.

Author

Parker, Rachel, Kilembe, William, Inambao, Mubiana, Priddy, Frances, Fast, Pat, Price, Matt, Tichacek, Amanda, Hunter, Eric, and Allen, Susan

Abstract

An abstract of the article "Use of Virtual Cohorts in Zambia's Couples' Voluntary Counseling and Testing (CVCT) as a Screening Mechanism for Clinical Trials" by Tyronza Sharkey, Rachel Parker, William Kilembe and colleagues is presented.

Published
2014
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39. Detection of Vaccine Induced Mucosal Antibodies in Phase I HIV Preventative Vaccine Trials.

Author

Langat, Robert, Farah, Bashir, Ogola, Simon, Omosa-Manyonyi, Gloria, Mutua, Gaudensia, Outtara, Gina, Park, Harriet, Lehrman, Jennifer, Mwangi, Irene, Coutinho, Helen, Chetty, Paramesh, McMorrow, Martin, Cox, Josephine, Fast, Pat, Laufer, Dagna, Gilmour, Jill, and Anzala, Omu

Abstract

An abstract of the article "Detection of Vaccine Induced Mucosal Antibodies in Phase I HIV Preventative Vaccine Trials" by Phil Bergin and colleagues is presented.

Published
2014
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41. Prevalence of HIV, Sexual Transmitted Infections and High Risk Sexual Behaviors among Female Sex Workers in Kigali, Rwanda.

Author

Ingabire, Rosine, Karita, Etienne, Nyombayire, Julien, Sinabamenye, Robertine, Ahmed, Nuri, Nduwamungu, Jean Nepo, Radjabari, Sukaina, Oppert, Marydale, Price, Matt, Priddy, Frances, Fast, Pat, Tichacek, Amanda, and Allen, Susan

Abstract

An abstract of the article "Prevalence of HIV, Sexual Transmitted Infections and High Risk Sexual Behaviors among Female Sex Workers in Kigali, Rwanda" by Jeannine Mukamuyango and colleagues is presented.

Published
2014
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42. Recall of Acute Retroviral Symptoms in a Multicentre Cohort Study in Africa.

Author

Powers, Kimberley A., Karita, Etienne, Kamali, Anatoli, Kilemba, William, Allen, Susan, Hunter, Eric, Anzala, Omu, Fast, Pat, and Price, Matthew A.

Abstract

An abstract of the article "Recall of Acute Retroviral Symptoms in a Multicentre Cohort Study in Africa" by Eduard J. Sanders, Kimberley A. Powers, Etienne Karita and colleagues is presented.

Published
2014
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43. Participation of Individuals from Fishing Communities in a Simulated Vaccine Efficacy Trial in Preparation for Future HIV Prevention Work.

Author

Abaasa, Andrew, Bahemuka, Ubaldo, Mulondo, Jerry, Kibengo, Freddie, Ruzagira, Eugene, Kamali, Anatoli, and Fast, Pat

Abstract

An abstract of the article "Participation of Individuals from Fishing Communities in a Simulated Vaccine Efficacy Trial in Preparation for Future HIV Prevention Work" by Gershim Asiki, Andrew Abaasa, Ubaldo Bahemuka and colleagues is presented.

Published
2014
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44. Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses.

Author

Muir R, Metcalf T, Fourati S, Bartsch Y, Lugemwa JK, Canderan G, Alter G, Muyanja E, Okech B, Namatovu T, Namara I, Namuniina A, Ssetaala A, Mpendo J, Nanvubya A, Kitandwe PK, Bagaya BS, Kiwanuka N, Nassuna J, Biribawa VM, Elliott AM, de Dood CJ, Senyonga W, Balungi P, Kaleebu P, Mayanja Y, Odongo M, Fast P, Price MA, Corstjens PLAM, van Dam GJ, Kamali A, Sekaly RP, and Haddad EK

Abstract

The impact of endemic infections on protective immunity is critical to inform vaccination strategies. In this study, we assessed the influence of Schistosoma mansoni infection on host responses in a Ugandan fishing cohort given a Hepatitis B (HepB) vaccine. Concentrations of schistosome-specific circulating anodic antigen (CAA) pre-vaccination showed a significant bimodal distribution associated with HepB titers, which were lower in individuals with high CAA. We established that participants with high CAA had significantly lower frequencies of circulating T follicular helper (cTfh) subpopulations pre- and post-vaccination and higher regulatory T cells (Tregs) post-vaccination. Polarization towards higher frequencies of Tregs: cTfh cells can be mediated by changes in the cytokine environment favoring Treg differentiation. In fact, we observed higher levels of CCL17 and soluble IL-2R pre-vaccination (important for Treg recruitment and development), in individuals with high CAA that negatively associated with HepB titers. Additionally, alterations in pre-vaccination monocyte function correlated with HepB titers, and changes in innate-related cytokines/chemokine production were associated with increasing CAA concentration. We report, that by influencing the immune landscape, schistosomiasis has the potential to modulate immune responses to HepB vaccination. These findings highlight multiple Schistosoma -related immune associations that could explain abrogated vaccine responses in communities with endemic infections., Author Summary: Schistosomiasis drives host immune responses for optimal pathogen survival, potentially altering host responses to vaccine-related antigen. Chronic schistosomiasis and co-infection with hepatotropic viruses are common in countries where schistosomiasis is endemic. We explored the impact of Schistosoma mansoni ( S. mansoni ) infection on Hepatitis B (HepB) vaccination of individuals from a fishing community in Uganda. We demonstrate that high schistosome-specific antigen (circulating anodic antigen, CAA) concentration pre-vaccination, is associated with lower HepB antibody titers post-vaccination. We show higher pre-vaccination levels of cellular and soluble factors in instances of high CAA that are negatively associated with HepB antibody titers post-vaccination, which coincided with lower frequencies of circulating T follicular helper cell populations (cTfh), proliferating antibody secreting cells (ASCs), and higher frequencies of regulatory T cells (Tregs). We also show that monocyte function is important in HepB vaccine responses, and that high CAA is associated with alterations in the early innate cytokine/chemokine microenvironment. Our findings suggest that in individuals with high CAA and likely high worm burden, schistosomiasis creates and sustains an environment that is polarized against optimal host immune responses to the vaccine, which puts many endemic communities at risk for infection against HepB and other diseases that are preventable by vaccines.

Published
2023
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45. Assessment of Anti-HIV-1 Antibodies in Oral and Nasal Compartments of Volunteers From 3 Different Populations.

Author

Bergin PJ, Langat R, Omosa-Manyonyi G, Farah B, Ouattara G, Park H, Coutinho H, Laufer D, Fast P, Verlinde C, Bizimana J, Umviligihozo G, Nyombayire J, Ingabire R, Kuldanek K, Cox J, McMorrow M, Fidler S, Karita E, Gilmour J, and Anzala O

Subjects
Case-Control Studies, Enzyme-Linked Immunosorbent Assay, HIV Infections immunology, Humans, Kenya, Limit of Detection, Rwanda, United Kingdom, HIV Antibodies analysis, HIV Infections virology, HIV-1 immunology, Mouth virology, Nasal Cavity virology
Abstract

In this study, we assessed the feasibility of collecting standardized nasal and salivary samples at centers in Nairobi (Kenya), Kigali (Rwanda), and London (United Kingdom) using different collection devices and media (synthetic absorptive matrices versus flocked swabs, and Salimetrics oral swabs versus whole oral fluid collection). We detected anti-Gag (p24) and envelope (gp140) antibodies in both nasal fluid and salivary collections from all HIV-infected individuals, and cross-reactive anti-p24 antibodies were detected in 10% of HIV-uninfected individuals enrolled at one site. Collections from the nasal turbinates were comparable with samples collected deeper in the nasopharyngeal tract, and the yield of anti-p24 IgA in the whole oral fluid samples was higher than in samples collected from the parotid gland. We noted a trend toward reduced levels of anti-HIV antibody in the volunteers receiving anti-retroviral therapy. Levels of antibodies were stable over multiple collection visits. Overall, this study shows that nasal and salivary samples can be collected in a standardized manner over repeated visits in both low- and high-resource settings. These methods may be used in support for future HIV vaccine clinical trials.

Published
2016
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46. Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission.

Author

Kamali A, Price MA, Lakhi S, Karita E, Inambao M, Sanders EJ, Anzala O, Latka MH, Bekker LG, Kaleebu P, Asiki G, Ssetaala A, Ruzagira E, Allen S, Farmer P, Hunter E, Mutua G, Makkan H, Tichacek A, Brill IK, Fast P, Stevens G, Chetty P, Amornkul PN, and Gilmour J

Subjects
Africa South of the Sahara epidemiology, Cooperative Behavior, Female, Geography, HIV Infections transmission, Humans, Incidence, Male, Prevalence, Risk Factors, Biomedical Research organization & administration, Communicable Disease Control organization & administration, Community Networks organization & administration, HIV Infections epidemiology, HIV Infections prevention & control
Abstract

HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted HIV observational epidemiology studies in populations at risk for HIV infection as part of an HIV prevention and vaccine trial network. Annual HIV incidence ranged from below 2% to above 10% and varied by CRC and risk group, with rates above 5% observed in Zambian men in an HIV-discordant relationship, Ugandan men from Lake Victoria fishing communities, men who have sex with men, and several cohorts of women. HIV incidence tended to fall after the first three months in the study and over calendar time. Among suspected transmission pairs, 28% of HIV infections were not from the reported partner. Volunteers with high incidence were successfully identified and enrolled into large scale cohort studies. Over a quarter of new cases in couples acquired infection from persons other than the suspected transmitting partner.

Published
2015
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