13 results on '"Felis, C."'
Search Results
2. Infección crónica por el virus de la hepatitis C: un factor de riesgo independiente para la ateromatosis subclínica
- Author
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Revuelto Artigas, T., Zaragoza Velasco, N., Gómez Arbones, X., Vidal Ballester, T., Piñol Felis, C., Reñe Espinet, J.M., and Betriu Bars, A.
- Published
- 2019
- Full Text
- View/download PDF
3. Telomeres and telomerase in the clinical management of colorectal cancer
- Author
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Piñol-Felis, C., Fernández-Marcelo, T., Viñas-Salas, J., and Valls-Bautista, C.
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- 2017
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4. Telomeres and telomerase in the clinical management of colorectal cancer
- Author
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Piñol-Felis, C., primary, Fernández-Marcelo, T., additional, Viñas-Salas, J., additional, and Valls-Bautista, C., additional
- Published
- 2016
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5. Effect of Barley and Oat Consumption on Immune System, Inflammation and Gut Microbiota: A Systematic Review of Randomized Controlled Trials.
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Cortijo-Alfonso ME, Romero MP, Macià A, Yuste S, Moralejo M, Rubió-Piqué L, and Piñol-Felis C
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- Humans, Immune System drug effects, Whole Grains, Diet, C-Reactive Protein analysis, Acute-Phase Proteins, Carrier Proteins, Membrane Glycoproteins, Hordeum, Avena, Gastrointestinal Microbiome, Randomized Controlled Trials as Topic, Inflammation
- Abstract
Purpose of Review: The aim of this systematic review was to investigate the effects of whole grain Avena sativa and Hordeum vulgare L., or their isolated fractions, on immune and inflammatory functions, as well as their influence on gut microbiota. A structured literature search was undertaken in line with PRISMA guidelines. Randomized controlled trials (RCTs) that investigated the effects of oats or barley consumption in adults and reported ≥ 1 of the following: C-reactive protein (CRP), tumor necrosis factor (TNF-α), interleukin-6 (IL-6), IL-2, IL-8, IL-18, lipopolysacharide binding protein (LBP) or gut microbiota-related outcomes, were included., Recent Findings: A total of 16 RCTs were included, among which 6 studies recruited metabolically at-risk population, including individuals with overweight and obesity, metabolic syndrome or hypercholesterolemia. Additionally, 3 trials involved young healthy population, 5 trials targeted older individuals (aged over 50 years), and 2 studies encompassed populations with other disease states. A total of 1091 individuals were included in the evaluation of short-term (up to 14 days) and long-term (beyond 14 days, up to 90 days) supplementation with oats or barley-based products. 9 studies measured inflammatory biomarkers and 5 of them reported significant reductions, specifically in long-term studies. Notably, no evidence of anti-inflammatory benefits was found in healthy individuals, whereas studies involving metabolically at-risk populations showed promising reductions in inflammation. 13 studies measured the impact on gut microbiota, and collectively suggest that oats and barley food products can influence the composition of gut microbiota, associated in some cases with metabolic improvements. Oats and barley consumption may confer anti-inflammatory effects in metabolically at-risk populations and influence gut microbiota outcomes. However, no anti-inflammatory benefits were observed in healthy individuals. Results from this systematic review suggests caution in interpreting findings due to limited trials and variations in interventions and health conditions., (© 2024. The Author(s).)
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- 2024
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6. Metabolic profiling of (poly)phenolic compounds in mouse urine following consumption of hull-less and purple-grain barley.
- Author
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Cortijo-Alfonso ME, Yuste S, Friero I, Martínez-Subirà M, Moralejo M, Piñol-Felis C, Rubió-Piqué L, and Macià A
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- Animals, Mice, Male, Anthocyanins metabolism, Anthocyanins urine, Tandem Mass Spectrometry, Polyphenols metabolism, Polyphenols urine, Hydroxybenzoates metabolism, Hydroxybenzoates urine, Flavonoids metabolism, Flavonoids urine, Hordeum chemistry, Hordeum metabolism, Mice, Inbred BALB C
- Abstract
The present study attempted for the first time to investigate the metabolic fate of (poly)phenolic compounds provided by a hull-less and purple grain barley genotype biofortified in anthocyanins. Balb/c mice were supplemented either with standard purified diet (SD) or whole-grain barley supplemented diet (WGB) for six weeks. Subsequently, (poly)phenolic metabolites were determined in urine samples by UPLC-MS/MS, and the principal metabolic pathways were elucidated. Thirty-nine (poly)phenolics compounds were identified in WGB which were distributed between the free (58%) and bound (42%) fractions, encompassing anthocyanins, phenolic acids, flavan-3-ols and flavones. Upon WGB intake, forty-two (poly)phenolic metabolites were identified, predominantly comprising phase-II sulphate, glucuronide, and/or methylated conjugates, along with colonic catabolites. Noteworthy metabolites included peonidin-3- O -glucuronide, peonidin-3- O -6''- O -malonylglucoside, and peonidin-3- O -glucoside among anthocyanins; hydroxyphenylpropanoic acid- O -sulphate among phenolic acids; and 5-(3',4'-dihydroxyphenyl)-γ-valerolactone- O -sulphate among flavan-3-ols. Metabolites like phenylpropionic, phenylacetic, hydroxybenzoic, and hippuric acids were found in both WGB and SD groups, with higher levels after barley consumption, indicating both endogenous and polyphenolic metabolism origins. Overall, this study offers valuable insights into the metabolism of (poly)phenols in purple barley, setting the stage for future investigations into the health benefits linked to the consumption of purple grain barley.
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- 2024
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7. Chemopreventive effects of anthocyanins on colorectal and breast cancer: A review.
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Bars-Cortina D, Sakhawat A, Piñol-Felis C, and Motilva MJ
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- Animals, Anthocyanins pharmacology, Anthocyanins therapeutic use, Female, Humans, Anticarcinogenic Agents pharmacology, Breast Neoplasms drug therapy, Breast Neoplasms etiology, Breast Neoplasms prevention & control, Colorectal Neoplasms drug therapy, Colorectal Neoplasms etiology, Colorectal Neoplasms prevention & control
- Abstract
The present review has analyzed the scientific literature, available in the PubMed and Scopus databases, in order to summarize the current state of diet anthocyanin research in breast cancer (BC) and colorectal cancer (CRC) animal models but also for up-to-date human studies. For CRC, 28 preclinical and 9 clinical studies were selected in line with our search query in science databases. In relation to BC, 14 preclinical and 5 clinical studies were selected. Remarkably, all the preclinical studies, to a greater or lesser degree, suggested a chemoprevention effect of anthocyanin in BC/CRC rodent models. These encouraging results from animal models are not extrapolated to the same degree to human studies where, from the similar theoretical daily doses of anthocyanins in these studies, the opposite results were reported. Nevertheless, it is worth mentioning that the anthocyanin doses in the human studies carried out recently are low if we consider the estimated exposure to anthocyanins issued by the European Food Safety Agency (EFSA) or extremely low if we consider with caution the human equivalent dose based on body surface area from the preclinical dosage regimes used. Therefore, although some clinical data has demonstrated an inverse relation between anthocyanin consumption and BC/CRC, this could, in fact, be more relevant if we increase the daily human anthocyanin dose (as observed in animal model dose-effect studies) while new toxicological data for this flavonoid subtype are brought to light., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2022
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8. Metabolic Fate and Cardiometabolic Effects of Phenolic Compounds from Red-Fleshed Apple in Hypercholesterolemic Rats: A Comparative Study with Common White-Fleshed Apple. The AppleCOR Study.
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Yuste S, Ludwig IA, Romero MP, Piñol-Felis C, Catalán Ú, Pedret A, Valls RM, Fernández-Castillejo S, Motilva MJ, Macià A, and Rubió L
- Subjects
- Animals, Anthocyanins administration & dosage, Anthocyanins pharmacokinetics, Drug Synergism, Female, Flavonoids administration & dosage, Male, Photinia, Plant Extracts administration & dosage, Rats, Rats, Wistar, Species Specificity, Cardiotonic Agents, Fruit chemistry, Hypercholesterolemia drug therapy, Malus, Phenols administration & dosage, Phenols pharmacokinetics
- Abstract
The present study aims to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats are fed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W), or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis, and phenol biological metabolites are determined. Plasma, urine, and feces show a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan-3-ols are significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect is observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function is improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) is also observed. The findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan-3-ols, together with dihydrochalcones, compose a phenolic phytocomplex in red- and white-fleshed apples, respectively, which can act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats., (© 2021 Wiley-VCH GmbH.)
- Published
- 2021
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9. Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma/adenocarcinoma in an azoxymethane rat colon carcinogenesis model.
- Author
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Bars-Cortina D, Martínez-Bardají A, Macià A, Motilva MJ, and Piñol-Felis C
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- Adenocarcinoma metabolism, Adenocarcinoma pathology, Animals, Anthocyanins analysis, Anthocyanins metabolism, Azoxymethane adverse effects, Carcinogenesis, Colonic Neoplasms metabolism, Colonic Neoplasms pathology, Flavonoids analysis, Flavonoids metabolism, Fruit chemistry, Fruit metabolism, Galactosides analysis, Galactosides metabolism, Humans, Male, Malus chemistry, Plant Extracts analysis, Plant Extracts metabolism, Polyphenols analysis, Polyphenols metabolism, Rats, Rats, Wistar, Adenocarcinoma diet therapy, Colonic Neoplasms diet therapy, Malus metabolism
- Abstract
Colorectal cancer (CRC) is the fourth cancer with the most new cases reported in 2018 worldwide. Consumption of fruit and vegetables is a protective factor against the risk of CRC. Beyond this, flavonoids could orchestrate these healthy effects. Apart from containing the typical apple flavonoids, red-fleshed apples also contain anthocyanins, mainly cyanidin-3-O-galactoside (Cy3Gal). Through an azoxymethane rat carcinogenesis model, a study was carried out in order to assess the possible protective effects of apple polyphenols, with special attention to anthocyanins. In addition, apart from negative and positive controls, a group with chemotherapy with 5-fluorouracil (5FU) was included to compare their performance against the output collected from the animal treatments with white-fleshed apple (WF), red-fleshed apple (RF) and Cy3Gal (AE). Although the 5FU group presented the best performance towards aberrant crypt foci (ACF) inhibition (70.1%), rats fed with white-fleshed apples ('Golden Smoothee') were able to achieve 41.3% ACF inhibition, while none of the challenged treatments (WF, RF and AE) suffered mucin depletion in their colonocytes. Expression changes of 17 genes related to CRC were assessed. In detail, the ACF inhibition phenotype detected in 5FU and WF groups could be explained through the expression changes detected in the apoptosis-related genes of Aurka, p53 and Cox2. Moreover, in the apple consumption groups (WF and RF), a reduced protein expression of matrix metalloproteinases with gelatinase activity (MMP-2 and 9) was detected. Overall, our study suggests an effect of apple polyphenols and apple anthocyanin Cy3Gal against colon carcinogenesis, retarding/diminishing the appearance of the precancerous markers studied., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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10. Antiviral treatment does not improve subclinical atheromatosis in patients with chronic hepatitis caused by hepatitis C virus.
- Author
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Revuelto Artigas T, Betriu Bars À, Zaragoza Velasco N, Gómez Arbones X, Vidal Ballester T, Piñol Felis C, and Reñé Espinet JM
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- Adult, Aged, Carotid Artery Diseases blood, Carotid Artery Diseases diagnostic imaging, Carotid Artery Diseases drug therapy, Carotid Artery Diseases virology, Carotid Intima-Media Thickness, Female, Femoral Artery diagnostic imaging, Femoral Artery virology, Hepatitis C, Chronic blood, Hepatitis C, Chronic complications, Humans, Interferon alpha-2 therapeutic use, Interferon-alpha therapeutic use, Lipids blood, Male, Middle Aged, Plaque, Atherosclerotic blood, Plaque, Atherosclerotic diagnostic imaging, Plaque, Atherosclerotic virology, Polyethylene Glycols therapeutic use, Prospective Studies, Recombinant Proteins therapeutic use, Ribavirin therapeutic use, Risk Factors, Time Factors, Antiviral Agents therapeutic use, Hepacivirus, Hepatitis C, Chronic drug therapy, Plaque, Atherosclerotic drug therapy
- Abstract
Introduction: Chronic infection with hepatitis C virus is a risk factor for developing atheromatous plaques, although the possible effect of virus clearance is unknown. Our aim was to determine whether or not subclinical atheromatosis improved and there was any modification in the composition of the plaques 12 months after eradication of hepatitis C virus by direct-acting antiviral agents., Materials and Methods: Prospective study that included 85 patients with chronic hepatitis C virus infection in different stages of fibrosis who were on direct-acting antiviral agents. Patients with a cardiovascular history, diabetes and kidney disease were excluded. An arterial ultrasound (carotid and femoral) was performed to diagnose atheromatous plaques (defined as intima-media thickness ≥1.5mm) and the composition (percentage of lipids, fibrosis and calcium with HEMODYN4 software) was analysed at the beginning of the study and 12 months after stopping the therapy., Results: After follow-up no changes were detected in the intima-media thickness (0.65mm vs. 0.63mm, P=.240) or in the presence of plaques (65.9% vs 71.8%, P=.063). There was also no significant change in their composition or affected vascular territory, with an increase in blood lipid profile (P<.001) after 12 months of treatment. These results were confirmed in subgroups by severity of liver disease., Discussion: The eradication of hepatitis C virus by direct-acting antiviral agents does not improve the atheroma plaques and nor does it vary their composition, regardless of liver fibrosis. More prospective studies are needed to evaluate residual cardiovascular risk after virus eradication., (Copyright © 2019. Publicado por Elsevier España, S.L.U.)
- Published
- 2019
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11. Design, optimization and validation of genes commonly used in expression studies on DMH/AOM rat colon carcinogenesis model.
- Author
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Bars-Cortina D, Riera-Escamilla A, Gou G, Piñol-Felis C, and Motilva MJ
- Abstract
Colorectal cancer (CRC), also known as colon cancer, is the third most common form of cancer worldwide in men and the second in women and is characterized by several genetic alterations, among them the expression of several genes. 1,2-dimethylhydrazine (DMH) and its metabolite azoxymethane (AOM) are procarcinogens commonly used to induce colon cancer in rats (DMH/AOM rat model). This rat model has been used to study changes in mRNA expression in genes involved in this pathological condition. However, a lack of proper detailed PCR primer design in the literature limits the reproducibility of the published data. The present study aims to design, optimize and validate the qPCR, in accordance with the MIQE (Minimum Information for Publication of Quantitative Real-Time PCR Experiments) guidelines, for seventeen genes commonly used in the DMH/AOM rat model of CRC ( Apc, Aurka, Bax, Bcl2, β -catenin, Ccnd1, Cdkn1a, Cox2, Gsk3beta, IL-33, iNOs, Nrf2, p53, RelA, Smad4, Tnfα and Vegfa ) and two reference genes ( Actb or β - actin and B2m ). The specificity of all primer pairs was empirically validated on agarose gel, and furthermore, the melting curve inspection was checked as was their efficiency (%) ranging from 90 to 110 with a correlation coefficient of r
2 > 0.980. Finally, a pilot study was performed to compare the robustness of two candidate reference genes., Competing Interests: The authors declare there are no competing interests.- Published
- 2019
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12. In colon cancer, normal colon tissue and blood cells have altered telomere lengths.
- Author
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Valls-Bautista C, Piñol-Felis C, Reñé-Espinet JM, Buenestado-García J, and Viñas-Salas J
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- Aged, Aged, 80 and over, Blood Cells metabolism, Case-Control Studies, Colorectal Neoplasms blood, Colorectal Neoplasms genetics, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Prognosis, Biomarkers, Tumor genetics, Blood Cells pathology, Colon metabolism, Colorectal Neoplasms pathology, Telomere Homeostasis genetics
- Abstract
Background: Telomere length (TL) shortened occurs in colorectal carcinogenetic process. Our objective is to determine if it is only a local fact or there are alterations in normal colon cells and in other body cells., Methods: TL of tumoral and normal mucosa and leukocytes of 40 patients operated of colorectal cancer (CRC) and 40 control patients with normal colonoscopy were measured by Southern-blot. Groups were matched by the same localization as tumors, sex, and age., Results: In CRC patients, TRFL (Telomere Repeat Factor Length) leukocytes mean was 8.84 kpb, normal colonic mucosa 7.97 kpb, and tumoral mucosa 7.33 kpb (P < 0.001). In the 40 normal control patients, mean TRFL of colonic mucosa was 7.76 kpb, while in blood cells was 7.01 kpb (P < 0.001). We observed an inverse correlation between leukocytes TRFL and age (r(2) = 0.17, P = 0.008). Mucosa TRFL correlates significantly with patient's age (r(2) = 0.138, P = 0.018). TRFL of controls colonic mucosa correlates with TRFL of their blood cells (r(2) = 0.354, P < 0.001)., Conclusions: Normal colonic mucosa and leukocytes in CCR patients presents telomere altered in respect to normal patients. Telomere length in normal leukocytes could be an initial marker for colorectal cancer., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2015
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13. A non-digestible fraction of the common bean (Phaseolus vulgaris L.) induces cell cycle arrest and apoptosis during early carcinogenesis.
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Feregrino-Perez AA, Piñol-Felis C, Gomez-Arbones X, Guevara-González RG, Campos-Vega R, Acosta-Gallegos J, and Loarca-Piña G
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- Aberrant Crypt Foci chemically induced, Aberrant Crypt Foci drug therapy, Animals, Azoxymethane toxicity, Cell Line, Tumor, Colon cytology, Colon drug effects, Colon metabolism, Colonic Neoplasms drug therapy, Cooking, Dietary Carbohydrates analysis, Dietary Fiber analysis, Dietary Proteins analysis, Digestion, Flavonoids analysis, Male, Rats, Rats, Sprague-Dawley, Apoptosis drug effects, Carcinogenesis drug effects, Cell Cycle Checkpoints drug effects, Phaseolus chemistry, Plant Extracts pharmacology
- Abstract
We have previously demonstrated that the non-digestible fraction (NDF) from common cooked beans (P. vulgaris L., cv Negro 8025) inhibits azoxymethane (AOM)-induced colon cancer and influences the expression of genes involved in the induction of apoptosis and cell cycle arrest through the action of butyrate. The objective of this study was to identify cell cycle alterations and morphological changes induced by treatment with AOM and to examine the formation of colonic aberrant crypt foci (ACF) in male Sprague Dawley rats fed with these beans. Rats were fed control diets upon arrival and were randomly placed into four groups after one week of acclimatization: control, NDF (intragastric administration), NDF + AOM and AOM. Rats treated with NDF + AOM exhibited a significantly lower number of total colonic ACF with a notable increase in the number of cells present in the G1 phase (83.14%); a decreased proliferation index was observed in the NDF + AOM group when compared to AOM group. NDF + AOM also displayed a higher number of apoptotic cells compared to AOM group. NDF of cooked common beans inhibited colon carcinogenesis at an early stage by inducing cell cycle arrest of colon cells and morphological changes linked to apoptosis, thus confirming previous results obtained with gene expression studies.
- Published
- 2014
- Full Text
- View/download PDF
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