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1,463 results on '"Freitas, Rosa"'

18. Development of silanized bacterial cellulose aerogels for the incorporation of natural oils with healing properties: Copaiba (Copaifera officinalis), bourbon geranium (Pelargonium X ssp.) essential oils and buriti (Mauritia flexuosa) vegetable oil

Author

Pontes, Evellheyn Rebouças, de Souza Guedes, Luciana, da Silva, Thamyres Freire, Barbosa, Francisco Cesar Barroso, de Souza, Bartolomeu Warlene Silva, de Freitas Rosa, Morsyleide, Vieira, Rodrigo Silveira, and Andrade, Fábia Karine

Published
2024
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22. Oxidized Bacterial Cellulose Membranes Immobilized with Papain for Dressing Applications: Physicochemical and In Vitro Biological Properties

Author

Niédja Fittipaldi Vasconcelos, Pascale Chevallier, Diego Mantovani, Morsyleide de Freitas Rosa, Fernando José Soares Barros, Fábia Karine Andrade, and Rodrigo Silveira Vieira

Subjects
hemocompatibility, cytotoxicity, fibroblasts, keratinocytes, debridement, dressing, Pharmacy and materia medica, RS1-441
Abstract

This research consolidates our group’s advances in developing a therapeutic dressing with innovative enzymatic debridement, focusing on the physicochemical and in vitro biological properties of papain immobilized in wet oxidized bacterial cellulose (OxBC–Papain) dressing. OxBC membranes were produced with Komagataeibacter hansenii oxidized with NaIO4, and papain was immobilized on them. They were characterized in terms of enzyme stability (over 100 days), absorption capacity, water vapor transmission (WVT), hemocompatibility, cytotoxicity, and cell adhesion. The OxBC–Papain membrane showed 68.5% proteolytic activity after 100 days, demonstrating the benefit of using the OxBC wet membrane for papain stability. It had a WVT rate of 678 g/m2·24 h and cell viability of 99% and 86% for L929 and HaCat cells, respectively. The membranes exhibited non-hemolytic behavior and maintained 26% clotting capacity after 1 h. The wet OxBC–Papain membrane shows significant potential as a natural biomolecule-based therapeutic dressing for wound care, offering efficient debridement, moisture maintenance, exudate absorption, gas exchange, and hemostasis without cytotoxic effects or cell adhesion to the dressing. Further research, especially using in vivo models, is needed to assess its efficacy in inducing epithelialization. This study advances stomatherapy knowledge, providing a cost-effective solution for enzymatic debridement in healthcare.

Published
2024
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29. Use of biomarkers for predicting a malignant course in acute ischemic stroke: an observational case–control study

Author

Alexandre Guimarães de Almeida Barros, Lucas Roquim e Silva, Alberlúcio Pessoa, Antonio Eiras Falcão, Luiz Alexandre Viana Magno, Daniela Valadão Freitas Rosa, Marco Aurelio Romano Silva, Debora Marques de Miranda, and Rodrigo Nicolato

Subjects
Medicine, Science
Abstract

Abstract Acute ischemic stroke is a sudden neurological event caused by brain ischemia. Patients with large vessel occlusion are at high risk of developing significant cerebral edema, which can lead to rapid neurological decline. The optimal timing for decompressive hemicraniectomy to prevent further brain damage is still uncertain. This study aimed to identify potential predictors of severe brain edema. The data indicate that specific cytokines may help identify patients with a higher risk of developing life-threatening brain swelling in the early phase post-stroke. The association between a positive biomarker and the outcome was calculated, and three biomarkers—S100B protein, MMP-9, and IL-10—were found to be significantly associated with malignant edema. A model was derived for early predicting malignant cerebral edema, including S100B protein and IL-1 beta. These findings suggest that molecular biomarkers related to the ischemic cascade may be a helpful way of predicting the development of malignant cerebral edema in ischemic stroke patients, potentially widening the time window for intervention and assisting in decision-making. In conclusion, this study provides insights into the molecular mechanisms of severe brain edema and highlights the potential use of biomarkers in predicting the course of ischemic stroke.

Published
2023
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