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4 results on '"Fu,Binfan"'

1. Causal relationship between diabetes mellitus and lung cancer: a two-sample Mendelian randomization and mediation analysis.

Author

Yu, Xiaolin, Fu, Binfan, Sun, Taizhen, and Sun, Xu

Subjects
TYPE 1 diabetes, MENDELIAN randomization, LUNG cancer, DIABETES, SQUAMOUS cell carcinoma, LUNGS
Abstract

Background: Diabetes mellitus (DM) is the common comorbidity with lung cancer (LC), and metabolic disorders have been identified as significant contributors to the pathogenesis of both DM and LC. The causality between diabetes mellitus and lung cancer is still controversial. Hence, the causal effects of DM on the risk of LC was systemically investigated, and the mediating role of blood metabolites in this relationship was further explored. Methods: This study utilized a comprehensive Mendelian randomization (MR) analysis to investigate the association between diabetes mellitus and lung cancer. The inverse variance weighted method was employed as the principle approach. MR Egger and weighted median were complementary calculations for MR assessment. A two-step MR analysis was performed to evaluate the mediating effects of blood metabolites as potential intermediate factors. Simultaneously, sensitivity analyses were performed to confirm the lack of horizontal pleiotropy and heterogeneity. Results: The two-sample MR analysis illustrated the overall effect of type 1 diabetes mellitus (T1DM) on lung squamous cell carcinoma (LUSC) (OR: 1.040, 95% CI: 1.010–1.072, p = 0.009). No causal connection was found between T2DM and the subtypes of lung cancer. Two-step MR identified two candidate mediators partially mediating the total effect of T1DM on LUSC, including glutamine conjugate of C6H10O2 levels (17.22%) and 2-hydroxyoctanoate levels (5.85%). Conclusion: Our findings supported a potentially causal effect of T1DM against LUSC, and shed light on the importance of metabolites as risk factors in understanding this relationship. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Biosynthesis, characterization, and anticancer effect of plant-mediated silver nanoparticles using Coptis chinensis

Author

Pei, Junwen, Fu, Binfan, Jiang, Lifeng, and Sun, Taizhen

Subjects
Coptis chinensis, silver nanoparticles, Silver, Metal Nanoparticles, Antineoplastic Agents, Apoptosis, Microbial Sensitivity Tests, X-Ray Diffraction, Cell Movement, International Journal of Nanomedicine, Spectroscopy, Fourier Transform Infrared, Humans, Neoplasm Invasiveness, Original Research, Bacteria, Plant Extracts, Spectrometry, X-Ray Emission, Green Chemistry Technology, invasion, Dynamic Light Scattering, Anti-Bacterial Agents, lung cancer, A549 Cells, antimicrobial, Spectrophotometry, Ultraviolet, Coptis
Abstract

Junwen Pei, Binfan Fu, Lifeng Jiang, Taizhen Sun Department of Integrated Traditional Chinese and Western Medicine, The Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450008, China Background: Tremendous growth in nanotechnology has opened up new frontiers in fundamental and applied aspects, including the synthesis of nanoscale matter and understanding/utilizing its exotic physicochemical and optoelectronic properties. Green-synthesis methods employing either biological microorganisms or plant extracts have emerged as a simple and alternative to chemical synthesis. Methods: In our present study, we aimed to synthesize silver nanoparticles (AgNPs) in combination with an aqueous extract of Coptis chinensis (CC) using a suitable ecofriendly green-synthesis way. Results: In our results, ultraviolet-visible spectroscopy revealed a near-absorbance peak at 450 nm, which confirmed the AgNP synthesis. The crystalline nature of the AgNPs was revealed with X-ray diffraction. Transmission electron-microscopy analysis showed spherically dispersed nanoparticles of 6–45 nm diameter. We analyzed the elementary mechanism across A549 lung carcinoma cells ahead of treatment with doses of CC-AgNPs (10 µg/mL and 25 µg/mL). The antiproliferative effect of CC-AgNPs revealed a significant decline in cell viability. Antibacterial assays with both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria exhibited a higher zone of inhibition against S. aureus. Conclusion: Furthermore, CC-AgNPs regulated apoptosis using the intrinsic pathway to inhibit A549-cell proliferation. Proliferation migration and invasion were notably inhibited by CC-AgNPs, which promoted apoptosis in lung adenocarcinoma cells by regulating the apoptotic pathway. Keywords: Coptis chinensis, silver nanoparticles, antimicrobial, lung cancer, apoptosis, invasion

Published
2019

4. Biosynthesis, characterization, and anticancer effect of plant-mediated silver nanoparticles using Coptis chinensis

Author

Pei,Junwen, Fu,Binfan, Jiang,Lifeng, Sun,Taizhen, Pei,Junwen, Fu,Binfan, Jiang,Lifeng, and Sun,Taizhen

Abstract

Junwen Pei, Binfan Fu, Lifeng Jiang, Taizhen Sun Department of Integrated Traditional Chinese and Western Medicine, The Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450008, China Background: Tremendous growth in nanotechnology has opened up new frontiers in fundamental and applied aspects, including the synthesis of nanoscale matter and understanding/utilizing its exotic physicochemical and optoelectronic properties. Green-synthesis methods employing either biological microorganisms or plant extracts have emerged as a simple and alternative to chemical synthesis. Methods: In our present study, we aimed to synthesize silver nanoparticles (AgNPs) in combination with an aqueous extract of Coptis chinensis (CC) using a suitable ecofriendly green-synthesis way. Results: In our results, ultraviolet-visible spectroscopy revealed a near-absorbance peak at 450 nm, which confirmed the AgNP synthesis. The crystalline nature of the AgNPs was revealed with X-ray diffraction. Transmission electron-microscopy analysis showed spherically dispersed nanoparticles of 6–45 nm diameter. We analyzed the elementary mechanism across A549 lung carcinoma cells ahead of treatment with doses of CC-AgNPs (10 µg/mL and 25 µg/mL). The antiproliferative effect of CC-AgNPs revealed a significant decline in cell viability. Antibacterial assays with both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria exhibited a higher zone of inhibition against S. aureus. Conclusion: Furthermore, CC-AgNPs regulated apoptosis using the intrinsic pathway to inhibit A549-cell proliferation. Proliferation migration and invasion were notably inhibited by CC-AgNPs, which promoted apoptosis in lung adenocarcinoma cells by regulating the apoptotic pathway. Keywords: Coptis chinensis, silver nanoparticles, antimicrobial, lung cancer, apoptosis, invasion

Published
2019

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