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Pleurotus ostreatus cv. Florida is one of the widely used edible mushroom. The polysaccharides from this mushrooms have been studied for antidiabetic potential; however, no efforts have been made to explore the potential of this mushroom to influence carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was undertaken to investigate the inhibitory potential of Pleurotus ostreatus cv. Florida on enzymes α-amylase and α-glucosidase. Several concentrations of extracts were used to study inhibition of enzymatic activity of α-amylase and α-glucosidase. A dose dependent inhibitory effect on enzymes was observed. The current study, for the first time, uncovered α-amylase and α-glucosidase inhibitory potential of Pleurotus ostreatus cv. Florida. The study could be helpful to isolate and characterize compounds responsible for it. [ABSTRACT FROM AUTHOR]

Plant, mineral, and animal products have been utilized as medications from the beginning of time to cure a variety of ailments. Use of medicinal herbs to modulate immune function has a rich history. Natural products serve as the foundation for contemporary pharmaceutical ingredients. Immunomodulation alters an individual's immune system by interfering with its normal processes. Immunomodulators derived from natural sources have been extensively studied in order to modify the immune system and prevent illness. Berberine is an alkaloid has been identified for its anti-inflammatory properties. In animal studies, Berberine was found to demonstrate analgesic properties. The current work is aimed to explore the in silico interactions of Berberine with various chemokines and inflammatory pathways. Berberine was docked with TNF-α, IL-1β, IL-6, and NOs in this investigation. Docking study demonstrated notable interactions with these targets. The present research provides insight into the development of new compounds for immunomodulation and the management of inflammatory illnesses. More research on Berberine and related flavonoids is necessary to assess its safety. As a result, Berberine can be regarded as a candidate for the advancement of an immunomodulatory agent. [ABSTRACT FROM AUTHOR]

Byline: Shagun. Dubey, Aditya. Ganeshpurkar, Divya. Bansal, Nazneen. Dubey Objective: To study the effect of the co-administration of phenytoin (PHT) and rutin in comparison with PHT and piracetam (PIM) on [...]

Byline: Neelofar. Khan, Aditya. Ganeshpurkar, Nazneen. Dubey, Divya. Bansal Objectives: Wheat grass (Triticum aestivum) is a gift of nature given to mankind. A number of scientific research on wheatgrass establishes [...]

Byline: Shagun. Dubey, Aditya. Ganeshpurkar, Divya. Bansal, Nazneen. Dubey Aim: The severity of adverse reactions due to antiepileptics is observed during initiation and early treatment in which impairment of cognitive [...]

The contemporary scientific community has presently recognized flavonoids to be a unique class of therapeutic molecules due to their diverse therapeutic properties. Of these, catechin, also, has been explored for a number of pharmacological effects. The present review aims to document the therapeutic potential of catechin. Tea leave, catechu, and much more possess catechin as one of the active constituents. Today, catechin has been observed for its nutraceutical effect. The objective of this review is to examine the evidence of the effectiveness and pharmacological effects of catechin. Preclinical, as well as randomized controlled clinical trials pertaining to studies of catechin, are included in the study. Chemical properties of catechin and its structure-activity relationship about various biological activities have also been documented. The review revealed protective effects of catechin on functions and integrity of liver, kidney, heart, and agerelated memory impairment. Catechin demonstrated the antimicrobial, anticancer, antihypertensive, anticoagulant, and antiulcer effect. The present review highlights the current information and the health-promoting effects of catechin. Along with this, the chemotherapeutic potential of the same has also been discussed. [ABSTRACT FROM AUTHOR]

The inflammation was observed by a sequence of comprehensive, correlated prevalence which causes enrollment of macrophages along with by removal of foreign particles and instigation of tissue repair. Though, massive release of chemokine and cytokines from macrophages can cause the progression of auto-inflammation and auto-immune diseases. The control overproduction of these mediators without damaging macrophages seems to be a novel strategy to control inflammation. Plants have been an integral part of the health-care system since ancient times. Many modern-day pharmaceuticals find their origin from phytochemicals. Rutin, catechin, and hesperidin are well-recognized for analgesic, anti-inflammatory and antiarthritic effects. Scientific reports rationalize their protective effect on humoral and cell-mediated immunity. The present study is focused to determine the immunomodulatory effect of rutin, catechin, and hesperidin on macrophage function. Rat peritoneal macrophages were harvested and cultured in the presence of lipopolysaccharides (LPS) and hesperidin. MTT assay was performed to determine macrophage viability. The levels of TNF-α, IL-1β, IL-6 were determined by ELISA kits whereas NO levels were determined by Griess method. The results of the present study revealed a decrease in levels of TNF-α, IL-1β, IL-6 and NO in LPS treated groups. In conclusion, LPS activated the macrophage by promoting the production of immune mediators, whereas rutin, catechin, and hesperidin treatment showed anti-inflammatory activities by suppressing the cytokine production in rat macrophages. [ABSTRACT FROM AUTHOR]

Context: Haphazard use of drugs is one of the key reasons for progression of liver diseases. Drugs such as paracetamol, isoniazid, rifampicin etc. cause hepatotoxicity. There is currently no single synthetic drug which is effective for the treatment of such conditions. Drugs from natural sources have been used by humans since before written records. Thus, plants serve to be an important source to explore hepatoprotectives. Objective: The current study was designed to assess the hepatoprotective activity of Glycyrrhiza glabra extract. Materials and Methods: Glycyrrhiza glabra roots were dried in shade, powdered and extracted with ethanol and phytochemical screening was performed. The extract phenolic and flavonoids contents were estimated. Hepatoprotective studies were performed using isoniazid- rifampicin induced hepatotoxicity in rats. Results: Results of the phytochemical studies demonstrated that the extract was rich in flavonoids, glycosides and polyphenolics. The extract also demonstrated excellent hepatoprotective activity against isoniazid- rifampicin induced hepatotoxicity in rats. Discussion and Conclusion: Results of study demonstrate that ethanol extract of Glycyrrhiza glabra is potent source of phytochemicals that are responsible to demonstrate hepatoprotective activity. [ABSTRACT FROM AUTHOR]

The modern scientific society has presently recognized flavonoids to be a unique class of therapeutic molecules due to their varied therapeutic properties. Of these, hesperidin, found along with vitamin C, has been explored for a number of pharmacological effects. Citrus and oranges possess hesperidin as one of the active constituents. Today, hesperidin has been well recognized for its beneficial effects on health. The present review highlights the current information and healthpromoting effects of hesperidin. The review uncovers protective effects of hesperidin on functions and integrity of liver, kidney, heart, and age related memory impairment. Hesperidin demonstrated the antimicrobial, anticancer, antihypertensive and antiulcer effect. The present review focus on current information of hesperidin and its active metabolite hesperetin. Along with this, the chemotherapeutic potential of the same has also discussed. [ABSTRACT FROM AUTHOR]

Forms eternal era, plant, mineral and animal products are used as drugs for the treatment of various diseases. The use of medicinal plants for immunomodulation has a long history. The modern medicinal compounds find their leads in natural products. Immunomodulation amends the immune system of an individual by prying with its usual functions. Discovery of immunomodulators from natural sources has been comprehensively made to modulate the immune system to prevent diseases. Hesperidin has been investigated for its potential anti-inflammatory effects. Hesperidin demonstrated analgesic effects in experimental animals. The present study is focused on exploring the in silico interaction of hesperidin with some chemokines and inflammatory targets. In this study, hesperidin was docked with TNF-a, IL-ip, IL-6, and NOs. Docking studies revealed the excellent interaction of hesperidin with these targets. The result of this work provided an insight into the discovery of novel molecules for immunomodulation and treatment of inflammatory disorders. Additional studies on hesperidin and associated flavonoids are necessary to establish its safety. Hesperidin, can, therefore, can be considered as a candidate for development of an immunomodulatory agent. [ABSTRACT FROM AUTHOR]