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Your search keyword '"García Mena M."' showing total 4 results
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4 results on '"García Mena M."'

1. Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease

Author

Cambray S., Bermudez-Lopez M., Bozic M., Valdivielso J.M., Castro E., María V., Molí T., Vidal T., Soria M., Aladrén Regidor Ma.J., Almirall J., Ponz E., Arteaga Coloma J., Bajo Rubio Ma.A., Belart Rodríguez M., Gascón A., Bover Sanjuan J., Puigvert F., Bronsoms Artero J., Cabezuelo Romero J.B., Muray Cases S., Calviño Varela J., Caro Acevedo P., Carreras Bassa J., Cases Amenós A., Massó Jiménez E., Moreno López R., Cigarrán Guldris S., López Prieto S., Comas Mongay L., Comerma I., Compte Jové Ma.T., Cuberes Izquierdo M., de Álvaro F., Hevia Ojanguren C., de Arriba de la Fuente G., del Pino y Pino Ma.D., Diaz-Tejeiro Izquierdo R., Hormigos A., Dotori M., Duarte V., Estupiñan Torres S., Fernández Reyes Ma.J., Fernández Rodríguez Ma.L., Fernández G., Galán Serrano A., García Cantón C., García Herrera A.L., García Mena M., Gil Sacaluga L., Aguilar M., Górriz J.L., Huarte Loza E., Lerma J.L., Liebana Cañada A., Marín Álvarez J.P., Martín Alemany N., Martín García J., Martínez Castelao A., Martínez Villaescusa M., Martínez I., Moina Eguren I., Moreno Los Huertos S., Mouzo Mirco R., Munar Vila A., Muñoz Díaz A.B., Navarro González J.F., Nieto J., Carreño A., Novoa Fernández E., Ortiz A., Fernandez B., Paraíso V., Pérez Fontán M., Peris Domingo A., Piñera Haces C., Prados Garrido Ma.D., Prieto Velasco M., Puig Marí C., Rivera Gorrín M., Rubio E., Ruiz P., Salgueira Lazo M., Martínez Puerto A.I., Sánchez Tomero J.A., Sánchez J.E., Sans Lorman R., Saracho R., Sarrias M., Serón D., Soler M.J., Barrios C., Sousa F., Toran D., Tornero Molina F., Usón Carrasco J.J., Valera Cortes I., Vilaprinyo del Perugia Ma.M., Ruiz V., Pallarés V., Altozano C.S., Ródenas M.A., Sanitaria de Arán I.G.G.Á.B., Gil F.A., Criado E.G., Belinchón R.D., Fernández Toro J.Ma., and Antonio J.

Subjects
cardiovascular risk, genetic association, adult, genotype, allele, chronic kidney failure, cohort analysis, major clinical study, Klotho protein, Article, homozygote, aged, cause of death, female, multicenter study, male, priority journal, cardiovascular mortality, single nucleotide polymorphism, follow up, human, prospective study
Abstract

Background. Chronic kidney disease (CKD) is associated with an elevated risk of all-cause mortality, with cardiovascular death being extensively investigated. However, non-cardiovascular mortality represents the biggest percentage, showing an evident increase in recent years. Klotho is a gene highly expressed in the kidney, with a clear influence on lifespan. Low levels of Klotho have been linked to CKD progression and adverse outcomes. Single nucleotide polymorphisms (SNPs) of the Klotho gene have been associated with several diseases, but studies investigating the association of Klotho SNPs with noncardiovascular death in CKD populations are lacking. Methods. The main aim of this study was to assess whether 11 Klotho SNPs were associated with non-cardiovascular death in a subpopulation of the National Observatory of Atherosclerosis in Nephrology (NEFRONA) study (n ¼ 2185 CKD patients). Results. After 48 months of follow-up, 62 cardiovascular deaths and 108 non-cardiovascular deaths were recorded. We identified a high non-cardiovascular death risk combination of SNPs corresponding to individuals carrying the most frequent allele (G) at rs562020, the rare allele (C) at rs2283368 and homozygotes for the rare allele (G) at rs2320762 (rs562020 GG/AG þ rs2283368 CC/CT þ rs2320762 GG). Among the patients with the three SNPs genotyped (n ¼ 1016), 75 (7.4%) showed this combination. Furthermore, 95 (9.3%) patients showed a low-risk combination carrying all the opposite genotypes (rs562020 AA þ rs2283368 TT þ rs2320762 GT/TT). All the other combinations [n ¼ 846 (83.3%)] were considered as normal risk. Using competing risk regression analysis, we confirmed that the proposed combinations are independently associated with a higher fhazard ratio [HR] 3.28 [confidence interval (CI) 1.51-7.12]g and lower [HR 6 × 10-6 (95% CI 3.3 × 10-7-1.1 × 10-5)] risk of suffering a non-cardiovascular death in the CKD population of the NEFRONA cohort compared with patients with the normal-risk combination. Conclusions. Determination of three SNPs of the Klotho gene could help in the prediction of non-cardiovascular death in CKD. © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2020
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2. [Prevalence of SARS-CoV-2 coronavirus infection in patients and professional staff at a medium or long-stay hospital in Spain].

Author

Moreno Borraz LA, Giménez López M, Carrera Lasfuentes P, González Pérez E, Ortíz Domingo C, Bonafonte Marteles JL, Vicente Gaspar C, Amorós de la Nieta F, Sastre Heres A, García Forcada ÁL, Serrano Herrero MP, Fernández Doblado S, Espinosa Val MC, Fernández Adarve MM, Narvión Carriquiri A, Arto Maza F, Barea Gil M, Aznar Vázquez I, Sisas Rubio R, González Tejedor R, Florentín Ostáriz E, López Santed C, Molina Morales AR, Parrilla Binué S, Pérez Sans J, García Mena M, Moragrega Cardona B, Luzón Alonso M, Díaz Mora F, Gil Acebes JC, Rubio Morilla Y, Lou Lou R, Zabala Lahoz RB, and Coarasa Lirón de Robles A

Subjects
Adult, Aged, Aged, 80 and over, Female, Hospitalization, Hospitals, Humans, Male, Middle Aged, Prevalence, Spain epidemiology, Young Adult, COVID-19 epidemiology, Occupational Diseases epidemiology, Occupational Diseases virology, Personnel, Hospital
Abstract

Background and Goals: The aim of the study is to know the prevalence of SARS-CoV-2 infection in patients and professional staff of a medium or long-stay hospital during the peak period of the pandemic in Spain, spring 2020., Material and Methods: At the end of February 2020, we developed at the hospital a strategy to diagnose the SARS-CoV-2 infection consisting of complementing the realization of PCR tests at real time with a quick technique of lateral flow immunochromatography to detect IgG and IgM antibodies against the virus. We also developed a protocol to realize those diagnostic tests and considered an infection (current or past) a positive result in any of the above tests. We included 524 participants in the study (230 patients and 294 hospital staff), and divided them into hospital patients and Hemodialysis outpatients. Furthermore, we divided the hospital staff into healthcare and non-healthcare staff. The documented period was from March, 20 th to April, 21 st , 2020., Results: 26 out of 230 patients tested positive in any of the diagnostic techniques (PCR, antibodies IgG, IgM) with a 11.30% prevalence. According to patients groups, we got a 14.38% prevalence in hospital patients vs. 5.95% in outpatients, with a significantly higher risk in admitted patients after adjustment for age and gender (OR=3,309, 95%CI: 1,154-9,495). 24 out of 294 hospital staff tested positive in any of the diagnostic techniques, with a 8.16% prevalence. According to the groups, we got a 8.91% prevalence in healthcare staff vs. 4.26% in non-healthcare staff. Thus, we do not see any statistically significant differences between hospital staff and patients as far as prevalence is concerned (P=0,391), (OR=2,200, 95%CI: 0,500-9,689)., Conclusions: The result of the study was a quite low prevalence rate of SARS-CoV-2 infection, in both patients and hospital staff, being the hospital patients' prevalence rate higher than the outpatients', and the healthcare staff higher than the non-healthcare's. Combining PCR tests (gold standard) with antibodies tests proved useful as a diagnostic strategy., (Copyright © 2020 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2021
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3. Association between vitamin D serum levels and inflammatory markers in patients on hemodialysis.

Author

Villafuerte-Ledesma HM, Moragrega B, Castillón E, Luzón-Alonso M, and García-Mena M

Subjects
Aged, Biomarkers blood, Blood Platelets cytology, C-Reactive Protein analysis, Cross-Sectional Studies, Female, Humans, Lymphocytes cytology, Male, Neutrophils cytology, Prevalence, Renal Insufficiency, Chronic therapy, Inflammation Mediators blood, Renal Dialysis, Renal Insufficiency, Chronic blood, Vitamin D blood, Vitamin D Deficiency blood, Vitamin D Deficiency epidemiology
Abstract

Introduction: The relationship between 25-OH-vitamin D and the immune system in patients with chronic kidney disease is a subject of attention., Objectives: To assess the prevalence of vitamin D deficiency in patients on hemodialysis and to investigate the association between vitamin D, ultra-sensitive C-reactive protein (US-CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)., Method: Cross-sectional study of 80 patients on hemodialysis, divided into two groups: a serum 25-OH-vitamin D level < 20 ng/mL was considered to be vitamin D deficiency and a serum level ≥ 20 ng/mL was regarded as normal. The relationship between the parameters was defined with Spearman's correlation analysis., Results: 40 % of the patients had vitamin D deficiency. There were significant differences between groups in US-CRP (p = 0.047), NLR (p = 0.039), PLR (p = 0.042) and treatment with vitamin D analogues (p = 0.022). Vitamin D had a significant negative correlation with US-CRP (p = 0.026), NLR (p = 0.013) and PLR (p = 0.022)., Conclusions: The prevalence of vitamin D deficiency was 40 %. The values of US-CRP, NLR and PLR were significantly higher in the presence of vitamin D deficiency. A significant inverse correlation was found between vitamin D levels and US-CRP, NLR and PLR., Introducción: La relación entre 25-OH-vitamina D y el sistema inmune en pacientes con enfermedad renal crónica es objeto de atención., Objetivos: Evaluar la prevalencia de la deficiencia de vitamina D en pacientes en hemodiálisis e investigar la asociación entre la vitamina D y proteína C reactiva ultrasensible (PCRus), índice neutrófilo-linfocito (INL) e índice plaqueta-linfocito (IPL)., Método: Estudio transversal de 80 pacientes en hemodiálisis, divididos en dos grupos: un nivel sérico de 25-OH-vitamina D < 20 ng/mL se consideró como deficiencia de vitamina D y ≥ 20 ng/mL, como normal. Con el análisis de correlación de Spearman se definió la relación entre los parámetros., Resultados: 40 % de los pacientes presentó deficiencia de vitamina D. Hubo diferencias significativas entre los grupos en PCRus (p = 0.047), INL (p = 0.039), IPL (p = 0.042) y tratamiento con análogos de vitamina D (p = 0.022). La vitamina D tuvo una correlación negativa significativa con PCRus (p = 0.026), INL (p = 0.013) e IPL (p = 0.022)., Conclusiones: La deficiencia de vitamina D fue de 40 %. Los niveles de PCRus, INL e IPL fueron significativamente más altos ante deficiencia de vitamina D. Se encontró correlación inversa significativa entre vitamina D y PCRus, INL e IPL., (Copyright: © 2020 Permanyer.)

Published
2020
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