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277 results on '"Gheonea, Dan"'

4. Introducing Colorectal Cancer Screening in Romania – Preliminary Results from the Regional Pilot Programs (ROCCAS)

Author

Manuc, Mircea, primary, Diculescu, Mircea, primary, Dumitru, Eugen, primary, Gheonea, Dan-Ionut, primary, Jinga, Mariana, primary, Ionita-Radu, Florentina, primary, Mergeani, Dina, primary, Udrescu, Mihaela, primary, Manuc, Teodora Ecaterina, primary, Cotruta, Bogdan, primary, Ungurean, Carmen, primary, Milanesi, Elena, primary, Dobre, Maria, primary, Stefan, Iulian, primary, Sanduleanu-Dascalescu, Silvia, primary, and Gheorghe, Cristian, primary

Published
2024
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5. Anesthesia Medication's Impacts on Inflammatory and Neuroendocrine Immune Response in Patients Undergoing Digestive Endoscopy.

Author

Popa-Ion, Denisa-Ancuța, Boldeanu, Lidia, Gheonea, Dan-Ionuț, Denicu, Madalina Maria, Boldeanu, Mihail Virgil, and Chiuțu, Luminița Cristina

Subjects
IMMUNE response, TUMOR necrosis factors, DRUGS, ENDOSCOPY, ANESTHESIA
Abstract

The aim of this study was to explore the impact of anesthetic drugs currently used to perform lower digestive endoscopy on serum concentrations of inflammation markers and catecholamines. We selected 120 patients and divided them into three lots of 40 patients each: L1, in which no anesthetics were used; L2, in which propofol was used; and L3, in which propofol combined with fentanyl was used. All patients had serum concentrations of adrenaline/epinephrine (EPI), noradrenaline/norepinephrine (NE), tumor necrosis factor alpha (TNF-α), interleukin-4 (IL-4), IL-6, IL-8, and IL-10, taken at three time points: at the beginning of the endoscopic procedure (T0), 15 min after (T1), and 2 h after the end of the endoscopic procedure (T2). The results of the research showed changes in the levels of catecholamines and interleukins (ILs) at T0, with an increased response in L1 above the mean recorded in L2 and L3 (p < 0.001). At T1, increased values were recorded in all lots; values were significantly higher in L1. At T2, the values recorded in L3 were significantly lower than the values in L2 (student T, p < 0.001) and L1, in which the level of these markers continued to increase, reaching double values compared to T0 (student T, p < 0.001). In L2 at T1, the dose of propofol correlated much better with NE, EPI, and well-known cytokines. Our results show that propofol combined with fentanyl can significantly inhibit the activation of systemic immune and neuroendocrine response during painless lower digestive endoscopy. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Safety, Efficacy and Persistence of Advanced Therapies in Inflammatory Bowel Disease: Results from ORIGINS. A Retrospective Observational Study

Author

Mateescu, Radu Bogdan, primary, Gheorghe, Cristian, primary, Trifan, Anca Victorita, primary, Saftoiu, Adrian, primary, Seicean, Andrada, primary, Diculescu, Mihai Mircea, primary, Banciu, Christian, primary, Gheorghe, Liliana Simona, primary, Busuioc, Bogdan, primary, Goldis, Adrian, primary, Dobru, Daniela, primary, Fratila, Ovidiu, primary, Eugen, Dumitru, primary, Bataga, Simona, primary, Constantinescu, Gabriel, primary, Gheonea, Dan, primary, Tantau, Alina, primary, Jinga, Mariana, primary, Brisc, Ciprian, primary, Cijevschi Prelipcean, Cristina, primary, Chira, Romeo, primary, Fierbințeanu-Braticevici, Carmen, primary, Dumitrascu, Dan, primary, State, Monica, primary, Voiosu, Theodor, primary, and Negreanu, Lucian, primary

Published
2023
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7. Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis

Author

Poenariu, Ioan Sabin, primary, Boldeanu, Lidia, additional, Ungureanu, Bogdan Silviu, additional, Caragea, Daniel Cosmin, additional, Cristea, Oana Mariana, additional, Pădureanu, Vlad, additional, Siloși, Isabela, additional, Ungureanu, Anca Marinela, additional, Statie, Răzvan-Cristian, additional, Ciobanu, Alina Elena, additional, Gheonea, Dan Ionuț, additional, Osiac, Eugen, additional, and Boldeanu, Mihail Virgil, additional

Published
2023
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9. Periodontal status and inflammatory markers in gingival crevicular fluid of patients with periodontitis and colorectal cancer

Author

Râmboiu, Sandu, primary, Nicolae, Flavia Mirela, additional, Soancă, Andrada, additional, Gheorghe, Dorin Nicolae, additional, Popescu, Dora Maria, additional, Ungureanu, Bogdan Silviu, additional, Mărgăritescu, Dragoș Nicolae, additional, Turcu-Știolica, Adina, additional, Boldeanu, Mihail Virgil, additional, Șurlin, Valeriu Marin, additional, Gheonea, Dan Ionuț, additional, and Șurlin, Petra, additional

Published
2023
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10. Freiburg personality inventory in inflammatory bowel disease: diagnosis and psychotherapeutic needs.

Author

Rada, Cornelia, Țieranu, Cristian George, Gheonea, Dan Ionut, and Ionescu, Elena Mirela

Subjects
INFLAMMATORY bowel diseases, CROHN'S disease, ULCERATIVE colitis, INTESTINAL diseases, PSYCHOTHERAPY, PESSIMISM, TALLIES, EXTRAVERSION
Abstract

Copyright of Anales de Psicología is the property of Servicio de Publicaciones de la Universidad de Murcia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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11. Assessment of Ileal Crohn’s Disease Activity by Gastrointestinal Ultrasound and MR Enterography: A Pilot Study

Author

Statie, Răzvan-Cristian, primary, Iordache, Sevastița, additional, Florescu, Lucian Mihai, additional, Gheonea, Ioana-Andreea, additional, Sacerdoțianu, Victor-Mihai, additional, Ungureanu, Bogdan Silviu, additional, Rogoveanu, Ion, additional, Gheonea, Dan-Ionuț, additional, Ciurea, Tudorel, additional, and Florescu, Dan Nicolae, additional

Published
2023
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16. Association between Direct-Acting Agents Adherence and Health-Related Quality of Life of Patients with Hepatitis C.

Author

PAULA DOICA, IRINA, TURCU-STIOLICA, ADINA, SILVIU UNGUREANU, BOGDAN, NICOLAE FLORESCU, DAN, ROGOVEANU, ION, and GHEONEA, DAN-IONUţ

Subjects
QUALITY of life, PATIENT compliance, HEPATITIS
Abstract

This observational study included all patients undergoing HCV treatment with direct-acting antiviral (DAA)-based therapy between May 2020 and September 2023 at the Dolj County Hospital, Romania. The aim was to investigate adherence to DAAs among HCV patients and the effect of this treatment on their health-related quality of life (HRQoL). Chronic HCV-infected patients were prospectively evaluated at baseline (T0), before the beginning of treatment, and 12 weeks after completing DAAs treatment (T1). The HCV-AD10 questionnaire was used to measure DAAs adherence, and HRQoL was assessed with the 15D instrument. The 15D questionnaire was administered at two time points: T0 and T1, during which the Sustained Virologic Response (SVR) was also measured. The primary outcome was DAAs adherence, with secondary outcomes including quality of life (QoL), and sustained virologic response (SVR). DAAs based therapy was initiated for 368 patients, all of whom were health insured. HRQoL and psychological state of HCV patients clinically improved. The DAAs adherence was very good (mean±SD, 91.51±8.34), being influenced by age (younger patients were much adherent, rho=-0.112, p-value=0.031) and the severity of the disease (patients with more severe hepatitis were less adherent, rho=-0.167, p-value=0.001). DAAs had a significant effect on improving HRQoL of HCV patients, but did not influence medication adherence. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Rare BRCA2 Mutation and MSI-H in Male Patient with Aggressive Stage III Colorectal Cancer, Case Report and Literature Review

Author

GHIMPAU, VALENTINA, UNGUREANU, BOGDAN SILVIU, GHEONEA, DAN-IONUT, LUNGULESCU, CRISTINA, and LUNGULESCU, CRISTIAN VIRGIL

Subjects
MSI-H, Case Report, Colorectal cancer, BRCA2
Abstract

Colorectal cancer is the third most common malignancy worldwide. We report the case of a 66-year-old man diagnosed with stage III B colorectal cancer who underwent radical surgery, adjuvant chemotherapy and subsequently developed hepatic metastases. Two months following metastasectomy, PET-CT scan revealed liver metastases with metabolic activity. The patient was started on FOLFIRI chemotherapy regimen in combination with cetuximab, and achieved stable partial remission 7 weeks after starting the treatment. NGS and IHC testing of the surgically removed tumor revealed MSI-H/dMMR, and NRAS/KRAS wild type status, moderate positive (30%) expression of PD-L1 protein, along with BRCA2 mutation.

Published
2021

20. Efficacy of Endobiliary Radiofrequency Ablation in Preserving Survival, Performance Status and Chemotherapy Eligibility of Patients with Unresectable Distal Cholangiocarcinoma: A Case-Control Study

Author

Sandru, Vasile, primary, Ungureanu, Bogdan Silviu, additional, Stan-Ilie, Madalina, additional, Oprita, Ruxandra, additional, Balan, Gheorghe G., additional, Plotogea, Oana-Mihaela, additional, Rinja, Ecaterina, additional, Butuc, Andreea, additional, Panaitescu, Afrodita, additional, Constantinescu, Alexandru, additional, Gheonea, Dan Ionut, additional, and Constantinescu, Gabriel, additional

Published
2022
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21. Heterogeneity in the Number of Astrocytes in the Central Nervous System after Peritonitis

Author

ROTARU-ZAVALEANU, ALEXANDRA DANIELA, NEACŞU, ALEXANDRU IONUŢ, COJOCARU, ALEXANDRU, OSIAC, EUGEN, and GHEONEA, DAN IONUT

Subjects
Original Paper, Sepsis, peritonitis, atrocytic response
Abstract

Sepsis remains a major medical emergency that describes the body's systemic immune response to an infectious process and can lead to end-stage organ dysfunction and death. Clinical studies have introduced the concept of sepsis associated encephalopathy, which seems to have a plethora of cellular and molecular triggers starting from systemic inflammatory cytokines, blood-brain barrier (BBB) rupture, microscopic brain injury, altered cerebral circulation, neurotransmission, or even metabolic dysfunction. The purpose of our study is to reproduce the sepsis model previously described using the cecal ligature and puncture (CLP), and to take a closer look to the acute modifications that occur on cellular level when it comes to the brain-blood-barrier of the mice with systemic inflammation. After a rapid systemic response to peritonitis, we show a heterogeneity in astrocytic response within different cortical structures; hippocampus having the longest change in the number of GFAP+cells, while no difference was seen in the number of cortical astrocytes. With even more increasing roles of astrocytes in different pathologies, the relation between sepsis and astrocytes could prove a valuable in discovering new therapy in sepsis.

Published
2021

22. Different Age Related Neurological and Cardiac Effects of Verapamil on a Transgenic Mouse Model of Alzheimer's Disease

Author

COJOCARU, ALEXANDRU, ZAVALEANU, ALEXANDRA DANIELA, CĂLINA, DANIELA CORNELIA, GHEONEA, DAN IONUT, OSIAC, EUGEN, BOBOC, IANIS KEVYN STEFAN, and MITRAN, SMARANDA IOANA

Subjects
Original Paper, age, Calcium blockers, Alzheimer’s
Abstract

Dementias are the third cause of the disability-adjusted life-years (DALYs) worldwide with Alzheimer's (AD) having the highest prevalence. Despite ample research in the field, therapeutic options are limited. However, with the increase in lifespan, a larger number of AD patients will receive other medication for the evermore-increased number of comorbidities that such patients face. The purpose of this study was to evaluate the neurological and cardiac effects of verapamil, on C57BL/6J-TgN (Thy1-APPKM670/671NL; Thy1-PS1L166P (APP) mice. The daily administration of 3.5mg/kg of verapamil for 28 days revealed different effects on young and aged APP mice. While young animals showed less anxiety and improved short-term memory with minimal cardiac effects (an increase in the duration of ventricular depolarization), aged ones did not present behavioral improvements, but with a decrease in the duration of ventricular depolarizing. Repolarization effects of verapamil were similar in young and aged animals, except for the duration of the ST segment that was longer in aged animals. Considering our results, the use of calcium blockers in AD patients should take into consideration the stage of the disease, as different effects could be seen at different stages of AD, in our model.

Published
2021

23. Rare Complication During Anti-TNF-α Treatment in a Patient with Crohn’s Disease: A Case Report and Review of the Literature

Author

STATIE, RĂZVAN-CRISTIAN, FLORESCU, DAN NICOLAE, GHEONEA, DAN-IONUŢ, and CIUREA, TUDOREL

Subjects
Crohn's disease, side effects, tuberculosis, adalimumab, Case Report, anti-TNF-α agents
Abstract

Crohn's disease represents an inflammatory bowel disease of unknown etiology, with chronic evolution, which may affect any segment of the digestive tract. The main classes of drugs used in patients with inflammatory bowel disease include: aminosalicylates, corticosteroids, immunosuppressants, biological agents and antibiotics. Biological therapy with anti-TNF-α agents offers significant therapeutic benefits, but their use requires caution, as they can also be associated with numerous side effects. We present the case of a female patient known with Crohn's disease, under going biological therapy with adalimumab, who developed a complication, quite rarely described in the literature, possibly as a result of treatment with anti-TNF-α agents.

Published
2021

24. Gastric Cancer Angiogenesis Assessment by Dynamic Contrast Harmonic Imaging Endoscopic Ultrasound (CHI-EUS) and Immunohistochemical Analysis—A Feasibility Study

Author

Sacerdoțianu, Victor Mihai, primary, Ungureanu, Bogdan Silviu, additional, Iordache, Sevastiţa, additional, Cazacu, Sergiu Marian, additional, Pirici, Daniel, additional, Liliac, Ilona Mihaela, additional, Burtea, Daniela Elena, additional, Șurlin, Valeriu, additional, Stroescu, Cezar, additional, Gheonea, Dan Ionuț, additional, and Săftoiu, Adrian, additional

Published
2022
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27. The Need for Oral Hygiene Care and Periodontal Status among Hospitalized Gastric Cancer Patients

Author

Nicolae, Flavia Mirela, primary, Bennardo, Francesco, additional, Barone, Selene, additional, Șurlin, Petra, additional, Gheorghe, Dorin Nicolae, additional, Burtea, Daniela, additional, Pătrascu, Ștefan, additional, Râmboiu, Sandu, additional, Radu, Adrian Petru, additional, Ungureanu, Bogdan Silviu, additional, Turcu-Știolica, Adina, additional, Didilescu, Andreea Cristiana, additional, Strâmbu, Victor Dan Eugen, additional, Șurlin, Valeriu Marin, additional, and Gheonea, Dan Ionuț, additional

Published
2022
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28. The Role of Neuropilin-2 in the Epithelial to Mesenchymal Transition of Colorectal Cancer: A Systematic Review

Author

Lungulescu, Cristina, Ghimpau, Valentina, Gheonea, Dan Ionut, Sur, Daniel, and Lungulescu, Cristian Virgil

Subjects
angiogenesis, neuropilin-2, QH301-705.5, Medicine (miscellaneous), cancer, metastasis, NRP2, Systematic Review, Biology (General), epithelial–mesenchymal transition, General Biochemistry, Genetics and Molecular Biology
Abstract

Neuropilin-2 (NRP-2) expression has been found in various investigations on the expression and function of NRP-2 in colorectal cancer. The link between NRP-2 and colorectal cancer, as well as the mechanism that regulates it, is still mostly unclear. This systematic review was carried out according to the Cochrane guidelines for systematic reviews. We searched PubMed, Embase®, MEDLINE, Allied & Complementary MedicineTM, Medical Toxicology & Environmental Health, DH-DATA: Health Administration for articles published before 1 October 2021. The following search terms were used: “neuropilin-2” “neuropilin 2”, “NRP2” and “NRP-2”, “colorectal cancer”, “colon cancer”. Ten articles researching either tumor tissue samples, cell lines, or mice models were included in this review. The majority of human primary and metastatic colon cancer cell lines expressed NRP-2 compared to the normal colonic mucosa. NRPs have been discovered in human cancers as well as neovasculature. The presence of NRP-2 appears to be connected to the epithelial–mesenchymal transition’s function in cancer dissemination and metastatic evolution. The studies were heterogeneous, but the data assessed indicates NRP-2 might have an impact on the metastatic potential of colorectal cancer cells. Nevertheless, further research is needed.

Published
2022

29. The Use of Endoscopic Ultrasonography in Inflammatory Bowel Disease: A Review of the Literature.

Author

Statie, Răzvan-Cristian, Florescu, Dan Nicolae, Gheonea, Dan-Ionuț, Ungureanu, Bogdan Silviu, Iordache, Sevastița, Rogoveanu, Ion, and Ciurea, Tudorel

Subjects
INFLAMMATORY bowel diseases, ENDOSCOPIC ultrasonography, CROHN'S disease, ULCERATIVE colitis, MAGNETIC resonance imaging, INTESTINAL diseases
Abstract

The diagnosis of inflammatory bowel disease (IBD) can sometimes be challenging. By corroborating clinical, imaging and histological data, the two main entities of IBD, ulcerative colitis and Crohn's disease (CD), can be differentiated in most cases. However, there remains 10–20% of patients where the diagnosis cannot be accurately established, in which case the term "IBD unclassified" is used. The imaging techniques most used to evaluate patients with IBD include colonoscopy, ultrasonography and magnetic resonance imaging. Endoscopic ultrasonography is mainly recommended for the evaluation of perianal CD. Through this work, we aim to identify other uses of this method in the case of patients with IBD. [ABSTRACT FROM AUTHOR]

Published
2023
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30. The Role of Analgesia in the Identification and Treatment of Digestive Tract Lesions: A Randomized, Prospective, Double-Blind Study.

Author

POPA-ION, DENISA-ANCUŢA, CHIUŢU, LUMINIŢA CRISTINA, DENICU, MĂDĂLINA MARIA, and GHEONEA, DAN-IONUŢ

Subjects
ALIMENTARY canal, ANALGESIA, PROPOFOL, FENTANYL, COGNITIVE ability
Abstract

The association of sedation with analgesia in endoscopic procedures represents the ideal combination of anesthetic drugs, which allows these exploratory procedures to be carried out safely, in an outpatient setting. The aim of this study is to compare the results of the use of simple Propofol or Propofol associated with Fentanyl in order to ensure optimal sedation necessary for the detection of benign or malignant lesions of the digestive tract. In this study, 80 patients aged between 18 and 80 years were included, 40 in Group 1 who were administered Propofol alone and 40 in Group 2 in which Propofol was administered associated with Fentanyl. The onset of anesthetic sleep was 19.3±5.1 seconds in Lot 2 versus 29.6±9.1 seconds in Lot 1. The average dose of Propofol used was 203.6±82.8 mg in Lot 1 and in Lot 2 it was lower, 166.3±8.3mg. Cardio respiratory changes were more frequent in Lot 2. The wake-up time was 3.2±1.2 minutes in Lot 1 as a result of the administration of Propofol alone and 7±1.4 minutes in Lot 2. The discharge time was equal for patients in both groups. The degree of postanesthesia safisfaction was 10 for all patients from Lot 2, due to the analgesia provided by the administration of Fentanyl. The use of Propofol associated with Fentanyl in gastrointestinal endoscopic procedures is associated with a rapid recovery of cognitive function at the time of discharge and minimal adverse events, ensuring optimal conditions of analgesia and stability of vital functions. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory Manifestations

Author

Drug, Vasile Liviu, primary, Antoniu, Sabina, primary, Oana, Barboi Bogdana, primary, Arghir, Oana Cristina, primary, Bancila, Ion, primary, Bataga, Simona, primary, Brisc, Ciprian, primary, Cijevschi-Prelipcean, Cristina, primary, Ciocîrlan, Mihai, primary, Ciortescu, Irina, primary, David, Liliana, primary, Deleanu, Oana Claudia, primary, Diculescu, Mircea, primary, Dimitriu, Anca, primary, Dobru, Daniela, primary, Dumitru, Eugen, primary, Gheonea, Dan Ionut, primary, Gheorghe, Cristian, primary, Goldis, Adrian, primary, Jinga, Mariana, primary, Man, Milena, primary, Mateescu, Bogdan, primary, Manuc, Mircea, primary, Mihai, Catalina, primary, Mihaltan, Florin, primary, Mihaescu, Traian, primary, Nedelcu, Laurentiu, primary, Negreanu, Lucian, primary, Pop, Carmen Monica, primary, Rajnoveanu, Ruxandra, primary, Saftoiu, Adrian, primary, Seicean, Andrada, primary, Sporea, Ioan, primary, Stanciu, Carol, primary, Surdea-Blaga, Teodora, primary, Tantau, Marcel, primary, Todea, Doina, primary, Trifan, Anca Victorita, primary, Ulmeanu, Ruxandra, primary, Iov, Diana Elena, primary, and Dumitrascu, Dan Lucian, primary

Published
2022
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32. Subgingival Periopathogens Assessment and Clinical Periodontal Evaluation of Gastric Cancer Patients—A Cross Sectional Pilot Study

Author

Nicolae, Flavia Mirela, primary, Didilescu, Andreea Cristiana, additional, Șurlin, Petra, additional, Ungureanu, Bogdan Silviu, additional, Șurlin, Valeriu Marin, additional, Pătrașcu, Ștefan, additional, Ramboiu, Sandu, additional, Jelihovschi, Igor, additional, Iancu, Luminita Smaranda, additional, Ghilusi, Mirela, additional, Cucu, Mihai, additional, and Gheonea, Dan Ionuț, additional

Published
2022
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33. Impact of biliary stenting in endoscopic ultrasound‐guided tissue acquisition among patients with pancreatic cancer

Author

Constantinescu, Alexandru, primary, Plotogea, Oana‐Mihaela, additional, Stan‐Ilie, Mădălina, additional, Ciurea, Tudorel, additional, Gheonea, Dan Ionut, additional, Ungureanu, Bogdan Silviu, additional, Bălan, Gheorghe, additional, Rinja, Ecaterina, additional, Panic, Nikola, additional, Şandru, Vasile, additional, and Constantinescu, Gabriel, additional

Published
2022
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39. Preliminary Results of the Micro-Elimination Project of Hepatitis C in a Disadvantaged Town in South-West of Romania-Orşova

Author

BUTARU, ANCA ELENA, DOICA, IRINA PAULA, GHEONEA, DAN IONUŢ, ROGOVEANU, ION, DICULESCU, MIRCEA, and OANCEA, CARMEN NICOLETA

Subjects
Original Paper, HCV elimination, sustained virological response, disadvantaged region screening
Abstract

Despite all recent advances in the diagnosis and treatment of hepatitis C virus infection, the incidence remains high, motivating the present study to improve the prognosis of the disease through early diagnosis of asymptomatic patients with possible detectable risk factors. The aim of this study is to identify HCV infection in a disadvantaged population before the onset of symptoms and guide to specialized services for initiation of antiviral therapy, thus adhering to the WHO goal of elimination the infection. Materials and Methods: In the first two weeks after the start of the study, 320 patients with detectable risk factors for HCV were tested using rapid tests, in a southwestern city of Romania, Orşova, with the participation of four doctors, via Family Medicine Offices. Results: As a percentage, the amount of detection based on rapid tests was 2.5%, the positive results have apparently been achieved exclusively among female subjects. All patients have been informed about the result and included in the diagnostic trial, where they were fully evaluated to determine if they were eligible for therapy. Conclusions. Population screening contributes to the diagnosis and elimination of an underdiagnosed pathology, in a disadvantaged area with limited access to medical care. The positive feedback that has been received in just a few weeks after its beginning, once again has motivated to emphasis the population screening, with real considerations on the possibility of expanding this program on a large scale.

Published
2020

44. Risk Factors for Extraintestinal Manifestations in Inflammatory Bowel Diseases - Data from the Romanian National Registry

Author

Singeap, Ana-Maria, primary, Girleanu, Irina, primary, Diculescu, Mircea, primary, Gheorghe, Liana, primary, Ciocîrlan, Maria, primary, Gheorghe, Cristian, primary, Costache, Adrian, primary, Tanțău, Alina, primary, Zaharie, Roxana, primary, Goldis, Adrian, primary, Gheonea, Dan, primary, Dobru, Daniela, primary, Dumitru, Eugen, primary, Prelipcean, Cristina Cijevschi, primary, Gîlcă-Blanariu, Georgiana-Emmanuela, primary, Moscalu, Mihaela, primary, Stanciu, Carol, primary, and Trifan, Anca, primary

Published
2021
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45. Comparative Study of Moderate Sedation with Propofol Versus Propofol Combined with Midazolam for Ambulatory Care Digestive Endoscopic Procedures.

Author

POPA-ION, DENISA-ANCUȚA, GHEONEA, DAN-IONUȚ, DENICU, MĂDĂLINA MARIA, and CHIUȚU, LUMINIȚA CRISTINA

Subjects
*PROPOFOL, *OUTPATIENT medical care, *MIDAZOLAM, *AMBULATORY surgery, *COMPARATIVE studies, *BRADYCARDIA
Abstract

Anesthesia is essential during colonoscopy because it provides patients with necessary sedation to perform the investigation safely and nonetheless to obtain the highest quality of the results. We aimed here to evaluate and establish which of the combinations of anesthetic drugs most frequently used for sedation purposes for gastrointestinal endoscopic procedures performed in the ambulatory best covers the needs of the patient and the gastroenterologist. This is a prospective, randomized, double-blind study carried out on a total of 100 patients, aged between 18 and 80 years, who meet the conditions for inclusion in the study. Patients were randomly allocated into either group A (Propofol) or group B (Midazolam plus Propofol). Evaluation of the dose of Propofol used in the 2 groups, awakening time, anesthetic induction, as well as the occurrence of episodes of bradycardia and hypotension represented the parameters followed in the study. In group A, 50 patients received on average 218.6mg of Propofol in bolus of 10-20mg. In group B, 50 patients received 0.1mg/kg Midazolam and an average of up to 129.2mg of Propofol in bolus of 10-20mg. Awakening time was shorter in group A-3.18 minutes, than in group B-15.7 minutes. Bradycardia and hypotension were met in a larger number in group B than in group A. The quality of the endoscopic evaluation was similar in both groups. The conclusion of our study was that the group to which only Propofol was administered had the best results from all aspects (rapid anesthetic induction, stability of vital functions, lower cost, awakening time much faster) compared to the combination of Propofol with Midazolam. [ABSTRACT FROM AUTHOR]

Published
2022
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47. ID: 3523607 TUMOR ANGIOGENESIS ASSESSED BY DYNAMIC CONTRAST HARMONIC IMAGING ENDOSCOPIC ULTRASOUND AND IMMUNOHISTOCHEMICAL ANALYSIS IN GASTRIC CANCER - A FEASIBILITY STUDY

Author

Mihai Sacerdotianu, Victor, primary, Ungureanu, Bogdan S., additional, Iordache, Sevastita, additional, Constantinescu, Codruta, additional, Cazacu, Sergiu M., additional, Pirici, Daniel, additional, Stroescu, Cezar, additional, Surlin, Valeriu, additional, Gheonea, Dan Ionut, additional, and Saftoiu, Adrian, additional

Published
2021
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