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Depression is a serious condition that is associated with great psychic suffering and major impairments on the patient's general health, quality of life, and social and occupational activities. In some cases, it may lead to suicide. Regardless of the innumerous research works that have already addressed depression in wide and specific facets, there is still a lot to grasp in order to effectively help preventing and treating depression. This work presents data from a randomized clinical trial that sought to evaluate the effectiveness of two brief psychotherapeutic for Depression: Cognitive Behavioral Therapy (CBT) and Supportive-Expressive Dynamic Psychotherapy (SEDP). This was a convenience sample composed of 46 individuals that were evaluated using a structured diagnostic interview and then randomly allocated to the SEDP group. We examined baseline and post-intervention serum levels of the Interleukin-6 (IL-6) and the Tumor Necrosis Factor (TNF-α) in addition to the severity of depressive symptoms according to the Outcome Questionnaire - 45.2 (OQ-45.2) and the Beck Depression Inventory (BDI). Results show that serum IL-6 and TNF-α levels, as well as the scores from the OQ-45.2 and the BDI significantly decreased after 16 sessions of SEDP (p < 0.001), except for the Interpersonal Relationship domain from the OQ-45. Despite the reduction of serum cytokines levels and OQ-45 and BDI scores, they were only significantly correlated regarding the social role domain from the OQ-45. Nonetheless, our data suggests an effective role of brief psychodynamic psychotherapy in the reduction of depressive symptoms and serum inflammatory levels that are associated with depression.

The aim of this study was to evaluate the effect of two brief psychotherapy models for major depressive disorder (MDD). This is a randomized clinical trial with 247 individuals diagnosed with MDD. Supportive-expressive dynamic psychotherapy (SEDP) (18 sessions) and cognitive-behavioral therapy (CBT) (16 sessions) were the two models used in this study. Participants were evaluated at baseline, during treatment, and postintervention (last session). Clinically significant changes were found in both psychotherapy models, and CBT showed higher response rates. Regarding the Beck Depression Inventory-II [F(1,120) = 4.07, p = 0.046] and Outcome Questionnaire 45.2 [F(1.114) = 7.99, p = 0.006], CBT had a better effect than SEDP. Hence, the results obtained have contributed to literature, served to corroborate the importance and effectiveness of psychodynamic psychotherapy, as well as explored the mechanisms of change, remission, and response in the treatment of MDD, which have been ignored to a large extent.

To evaluate the effect of cognitive therapy on biological rhythm and depressive and anxious symptoms in a twelve-month follow-up period. In addition, correlations between the reduction of depression and anxiety symptoms and the regulation of biological rhythm were observed.This was a randomized clinical trial with young adults from 18 to 29 years of age who were diagnosed with depression. Two models of psychotherapy were used: Cognitive Behavioral Therapy (CBT) and Narrative Cognitive Therapy (NCT). Biological rhythm was assessed with the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN). Severity of depressive and anxious symptoms was assessed by the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS), respectively. The sample included 97 patients who were divided within the protocols of psychotherapy.There was a significant reduction in depressive and anxious symptoms (p0.001) and an increase on regulation of biological rhythm (p0.05) at the twelve-month follow-up. Moreover, we showed a positive correlation between the reduction of depressive symptoms and regulation of biological rhythm (r=0.638; p0.001) and between the reduction of anxious symptoms and regulation of biological rhythm (r=0.438; p0.001).Both models showed that cognitive therapy was effective on the reduction of depressive and anxious symptoms and on the regulation of biological rhythm at a twelve-month follow-up evaluation. This study highlights the association between biological rhythm and symptoms of depression and anxiety.We did not assess genetic, hormonal or neurochemical factors and we did not include patients under pharmaceutical treatment or those with severe symptomatology.

Objectives To verify the prevalence of current posttraumatic stress disorder (PTSD) in young adults, the occurrence of comorbidities and its association with quality of life. Methods This is a cross-sectional population-based study. The targeted population consisted on individuals aged 18 to 24 years old, who lived in the urban area of Pelotas-RS, Brazil. Cluster sampling was applied. PTSD and its comorbidities were assessed using the Mini International Neuropsychiatric Interview (MINI 5.0), whereas quality of life was evaluated with the eight domains of the Medical Outcomes Survey Short-form General Health Survey (SF-36). Results A total of 1,762 young adults were selected. The prevalence of PTSD was 2.1% and current episode of depression was the most prevalent comorbidity (71.9%). The individuals with PTSD had lower scores in all domains of quality of life. Conclusion These findings indicate that PTSD is associated with other psychopathologies, especially depression, and it has a substantial impact over quality of life in a sample of young adults.

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-09-12T13:01:17Z No. of bitstreams: 3 Giovanna_Del_Grande_da_Silva_Alves.pdf: 1480052 bytes, checksum: d35fd8b618bd782bdff6ef801dfc68ef (MD5) giovanna 2.pdf: 128634 bytes, checksum: e25d780ccb5d47babf4f4c421249646b (MD5) Silva et al 2016 J Psych Research.pdf: 747242 bytes, checksum: 98e17c2c97366c098d5343dd88ec3b32 (MD5) Made available in DSpace on 2016-09-12T13:01:17Z (GMT). No. of bitstreams: 3 Giovanna_Del_Grande_da_Silva_Alves.pdf: 1480052 bytes, checksum: d35fd8b618bd782bdff6ef801dfc68ef (MD5) giovanna 2.pdf: 128634 bytes, checksum: e25d780ccb5d47babf4f4c421249646b (MD5) Silva et al 2016 J Psych Research.pdf: 747242 bytes, checksum: 98e17c2c97366c098d5343dd88ec3b32 (MD5) Previous issue date: 2016-02-24 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES# #2075167498588264571# #600 Depression is a serious disorder that causes major impairments to the individual and may affect general functioning, familial relations, social and occupational activities. Despite its high prevalence (worldwide and in the Brazilian population) and of the proved effectiveness of psychotherapy as a treatment modality, individuals who suffer from Depression frequently do not receive proper psychotherapeutic care due to the several structural complexities of the basic health systems. In addition, other characteristics, such as comorbidities (personality disorders included) may make the clinical improvement of these patients more difficult. Thus, it is crucial that psychotherapy strategies that may be applied to the public health system are identified and effectively proved in terms of biochemical and psychological measures. The general objective of this thesis is to evaluate general suffering, symptom distress, interpersonal relations, and social role performance accordingly to the presence of personality disorders. Moreover, it aims to verify the effectiveness of two brief psychodynamic and cognitive-behavioral psychotherapy models through the evaluation instruments and biochemical markers. The first work sought to associate inflammatory biomarkers (IL-6 and TNF-α) with the remission of depressive symptoms in the supportive-expressive dynamic psychotherapy (n=46). The evaluation of depressive symptoms was carried out through the Outcome Questionnaire-45 (OQ-45) and the Beck Depression Inventory-II (BDI). Results demonstrate the effectiveness of psychotherapy in reducing inflammatory biomarkers (p

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2019-05-20T12:11:01Z No. of bitstreams: 1 Mariana Carret Soares.pdf: 2646448 bytes, checksum: 703d8b3921b26f5fd34c541875f02232 (MD5) Made available in DSpace on 2019-05-20T12:11:01Z (GMT). No. of bitstreams: 1 Mariana Carret Soares.pdf: 2646448 bytes, checksum: 703d8b3921b26f5fd34c541875f02232 (MD5) Previous issue date: 2018-12-12 Introduction: Major depression is a disabling and high prevalence disorder and is associated with reduced quality of life, disability in social and personal relationships and impaired functionality of working life. Brief models of psychotherapy have proved effective and have in recent years been an increasing interest and commitment to the integration of this psychotherapy model with other mental health services in the context of primary care. Aims: The aim of this thesis is to evaluate the efficacy of two brief psychotherapy models for depression on the therapeutic progress and on the improvement of depressive symptoms at postintervention. As well as, evaluated the impact of these two brief psychotherapy models on patient’s functionality and on depressive and anxious symptomatology at twelve-month followup. Method: A randomized clinical trial was conducted with individuals of 18-60 tears of age who sought for psychotherapeutic treatment at the Clinic of Research and Extension in Mental Health of the Catholic University of Pelotas. The diagnose was conduct according to the Mini International Neuropsychiatric Interview – Plus (MINI-PLUS). Two models of psychotherapy were used: Supportive-Expressive dynamic psychotherapy (SEDP) (18 sessions) and Cognitive Behavior Therapy (CBT) (16 sessions). Therapeutic progress was evaluated through Outcome Questionnaire 45 (OQ-45) and the depressive symptoms through Beck depression inventory-II (BDI-II). Patients functionality was evaluated through Functional Assessment Short Test (FAST) and anxious symptoms through Beck Anxiety Inventory (BAI). Participants were evaluated at baseline, post-intervention (last session), at six-month and twelve-month followup. Results: Both models were effective in BDI-II improvement from baseline to post-intervention at CBT (p £ 0.05; Cohens’d = 1.27) and OQ-45 (p £ 0.05; Cohens’d = 1.42), and at SEDP group in BDI-II (p £ 0.05; Cohens’d = 1.09) and OQ-45 (p £ 0.05; Cohens’d = 1.13), no differences were found between the models for BDI-II (IC = -0.19 a 0.52) and OQ-45 (IC= -0.14 a 0.57). There was a significant increase in patient’s functionality in both models from baseline to twelve-month follow-up (F = 22.981, p < 0.001), in depressive symptoms (F = 50.054; p < 0.001) and anxious symptoms (F = 21.036; p < 0.001). there were no differences between models in all evaluation’s times. 9 Conclusion: Both models of psychotherapy were effective in improving depressive symptoms during the treatment for major depressive disorder, as well as had an impact in improving patient functionality and depressive and anxious symptomatology a year after its end. Introdução: A depressão maior é um transtorno incapacitante, bastante prevalente e está associada à redução da qualidade de vida, deficiência nas relações sociais e pessoais e prejuízo na funcionalidade da vida profissional. Os modelos breves de psicoterapia têm se mostrado eficazes, tendo nos últimos anos havido um crescente interesse e compromisso com a integração desses modelos com outros serviços de saúde mental no contexto de cuidados primários. Objetivos: Esta tese tem como objetivo avaliar a eficácia de dois modelos de psicoterapia breve para depressão no progresso terapêutico e na melhora de sintomas depressivos após a intervenção. Como também, avaliar o impacto destes dois modelos de psicoterapia breve na funcionalidade do paciente e na sintomatologia depressiva e ansiosa no follow-up de dozemeses. Método: Foi realizado um ensaio clínico randomizado com 247 indivíduos de 18 a 60 anos de idade que buscaram por tratamento psicoterapêutico no Ambulatório de Pesquisa e Extensão em Saúde Mental da Universidade Católica de Pelotas. O diagnóstico de transtorno depressivo maior foi realizado através da Mini International Neuropsychiatric Interview – PLUS (MINIPLUS). Os modelos de psicoterapia utilizados foram: Psicoterapia Dinâmica Suportiva- Expressiva (PDSE) (18 sessões) e Terapia Cognitiva-Comportamental (TCC) (16 sessões). O progresso terapêutico foi avaliado através do instrumento Outcome Questionnaire-45 (OQ-45) e os sintomas depressivos através do Beck Depression Inventory-II (BDI-II). A funcionalidade do paciente foi avaliada através da Functional Assesment Short Test (FAST) e a sintomatologia ansiosa através do Beck Anxiety Inventory (BAI). Participantes foram avaliados no início, durante o tratamento e após a intervenção (última sessão), como também no follow-up de seis e doze-meses. Resultados: Ambos modelos foram eficazes na melhora do BDI-II do baseline ao pósintervenção na TCC (p £ 0.05; Cohens’d = 1.27) e OQ-45 (p £ 0.05; Cohens’d = 1.42), e na PDSE no BDI-II (p £ 0.05; Cohens’d = 1.09) e OQ-45 (p £ 0.05; Cohens’d = 1.13), sem diferença entre os modelos para o BDI-II (IC = -0.19 a 0.52) e OQ-45 (IC= -0.14 a 0.57). Houve uma melhora na funcionalidade em ambos modelos do baseline ao follow-up de doze-meses (F = 22.981, p < 0.001), nos sintomas depressivos (F = 50.054; p < 0.001) e sintomas ansiosos (F = 21.036; p < 0.001). Não houve diferenças entre os modelos em todos os tempos de avaliação. Conclusão: Os dados demonstram que ambos os modelos de psicoterapia foram eficazes na melhora da autoavalição do progresso terapêutico e dos sintomas depressivos durante o 7 tratamento para o transtorno depressivo maior, como também tiveram impacto na melhora da funcionalidade e da sintomatologia ansiosa e depressiva um ano após o término.