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Your search keyword '"Glatz, Jan F.C."' showing total 45 results
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45 results on '"Glatz, Jan F.C."'

2. Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis

Author

Wang, Shujin, primary, Han, Yinying, additional, Liu, Ruimin, additional, Hou, Mengqian, additional, Neumann, Dietbert, additional, Zhang, Jun, additional, Wang, Fang, additional, Li, Yumeng, additional, Zhao, Xueya, additional, Schianchi, Francesco, additional, Dai, Chao, additional, Liu, Lizhong, additional, Nabben, Miranda, additional, Glatz, Jan F.C., additional, Wu, Xin, additional, Lu, Xifeng, additional, Li, Xi, additional, and Luiken, Joost J.F.P., additional

Published
2024
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11. Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations

Author

Abdurrachim, Desiree, Nabben, Miranda, Hoerr, Verena, Kuhlmann, Michael T., Bovenkamp, Philipp, Ciapaite, Jolita, Geraets, Ilvy M.E., Coumans, Will, Luiken, Joost J.F.P., Glatz, Jan F.C., Schäfers, Michael, Nicolay, Klaas, Faber, Cornelius, Hermann, Sven, and Prompers, Jeanine J.

Published
2017
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15. List of Contributors

Author

Beauloye, Christophe, primary, Berthiaume, Jessica M., additional, Bertrand, Luc, additional, Brown, David I., additional, Doenst, Torsten, additional, Glatz, Jan F.C., additional, Hue, Louis, additional, Kennel, Peter J., additional, Larsen, Terje S., additional, Lygate, Craig A., additional, Nabben, Miranda, additional, Nguyen, Tien Dung, additional, Niemann, Bernd, additional, Osterholt, Moritz, additional, Peterson, Linda R., additional, Rohrbach, Susanne, additional, Schrepper, Andrea, additional, Schulze, Paul Christian, additional, Schwarzer, Michael, additional, van Bilsen, Marc, additional, Werner, Christina, additional, Willis, Monte S., additional, and Young, Martin E., additional

Published
2016
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33. Palmitate-Induced Vacuolar-Type H+-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction

Author

Liu, Yilin, primary, Steinbusch, Laura K.M., additional, Nabben, Miranda, additional, Kapsokalyvas, Dimitris, additional, van Zandvoort, Marc, additional, Schönleitner, Patrick, additional, Antoons, Gudrun, additional, Simons, Peter J., additional, Coumans, Will A., additional, Geomini, Amber, additional, Chanda, Dipanjan, additional, Glatz, Jan F.C., additional, Neumann, Dietbert, additional, and Luiken, Joost J.F.P., additional

Published
2017
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37. Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring

Author

Van Ewijk, Petronella A., Paglialunga, Sabina, Kooi, M.E., Nunes, Patricia M., Gemmink, Anne, Slenter, Jos, Kornips, Esther, Jörgensen, Johanna A., Hoeks, Joris, Wildberger, Joachim E., Hesselink, Matthijs K.C., Glatz, Jan F.C., Heerschap, Arend, Kersten, Sander, Schrauwen, Patrick, and Schrauwen-Hinderling, Vera B.

Subjects
Voeding, Metabolisme en Genomica, Life Science, Nutrition, Metabolism and Genomics, VLAG
Abstract

Objective Parental high-fat feeding was proposed to negatively impact metabolic health in offspring. Here, the ectopic fat storage in heart and liver in offspring was investigated, and the effects on mitochondrial function, de novo lipogenesis, and postprandial lipid metabolism were explored in detail. Methods Male and female mice received either a high-fat (HF) or standard chow (LF) diet during mating, gestation and lactation. All offspring animals received the HF diet. Results Abdominal visceral adipose tissue tended to be higher in HF/HF mice. Cardiac lipid content was also higher in the HF/HF mice (LF/HF vs. HF/HF: 1.03% ± 0.08% vs. 1.33% ± 0.07% of water signal, P = 0.01). In contrast, hepatic lipid content tended to be lower in HF/HF mice compared to LF/HF mice. A severely disturbed postprandial lipid clearance was revealed in HF/HF mice by the results from the triglyceride (TG) tolerance tests (LF/HF vs. HF/HF: 6,753 ± 2,213 vs. 14,367 ± 1,978 mmol l-1 min-1, P = 0.01) and 13C-fatty acid retention test (LF/HF vs. HF/HF: 2.73% ± 0.85% vs. 0.89% ± 0.26% retention from bolus, P = 0.04), which may underlie the lower hepatic lipid content. Conclusions Here it is shown that HF diet negatively impacts postprandial TG clearance in offspring and results in an overall metabolic unfavorable phenotype and ectopic lipid deposition in the heart and in visceral storage sites.

Published
2015

39. The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content

Author

Oligschlaeger, Yvonne, primary, Miglianico, Marie, additional, Dahlmans, Vivian, additional, Rubio-Villena, Carla, additional, Chanda, Dipanjan, additional, Garcia-Gimeno, Maria Adelaida, additional, Coumans, Will A., additional, Liu, Yilin, additional, Voncken, J. Willem, additional, Luiken, Joost J.F.P., additional, Glatz, Jan F.C., additional, Sanz, Pascual, additional, and Neumann, Dietbert, additional

Published
2016
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40. Early health technology assessment of future clinical decision rule aided triage of patients presenting with acute chest pain in primary care.

Author

Willemsen, Robert T.A., Kip, Michelle M.A., Koffijberg, Hendrik, Kusters, Ron, Buntinx, Frank, Glatz, Jan F.C., and Dinant, Geert Jan

Subjects
CARDIOVASCULAR disease diagnosis, CHEST pain diagnosis, ACUTE coronary syndrome, BIOMARKERS, CLINICAL medicine, COST effectiveness, DIAGNOSTIC errors, EMERGENCY medicine, INFORMATION storage & retrieval systems, MEDICAL databases, MEDICAL care, MEDICAL technology, PATIENTS, PRIMARY health care, RESEARCH funding, MEDICAL triage, DECISION making in clinical medicine, DATA analysis software, DIAGNOSIS
Abstract

The objective of the paper is to estimate the number of patients presenting with chest pain suspected of acute coronary syndrome (ACS) in primary care and to calculate possible cost effects of a future clinical decision rule (CDR) incorporating a point-of-care test (PoCT) as compared with current practice. The annual incidence of chest pain, referrals and ACS in primary care was estimated based on a literature review and on a Dutch and Belgian registration study. A health economic model was developed to calculate the potential impact of a future CDR on costs and effects (ie, correct referral decisions), in several scenarios with varying correct referral decisions. One-way, two-way, and probabilistic sensitivity analyses were performed to test robustness of the model outcome to changes in input parameters. Annually, over one million patient contacts in primary care in the Netherlands concern chest pain. Currently, referral of eventual ACS negative patients (false positives, FPs) is estimated to cost €1,448 per FP patient, with total annual cost exceeding 165 million Euros in the Netherlands. Based on ‘international data’, at least a 29% reduction in FPs is required for the addition of a PoCT as part of a CDR to become cost-saving, and an additional €16 per chest pain patient (ie, 16.4 million Euros annually in the Netherlands) is saved for every further 10% relative decrease in FPs. Sensitivity analyses revealed that the model outcome was robust to changes in model inputs, with costs outcomes mainly driven by costs of FPs and costs of PoCT. If PoCT-aided triage of patients with chest pain in primary care could improve exclusion of ACS, this CDR could lead to a considerable reduction in annual healthcare costs as compared with current practice. [ABSTRACT FROM PUBLISHER]

Published
2018
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