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Background: Inflammatory myofibroblastic tumor (IMT) is an indolent tumor mainly affecting children and young adults. As a rare mesenchymal tumor with unknown etiology and pathogenesis, IMT has a predilection for the lung and abdominopelvic region. Previous literature featuring IMT in the central nervous system (IMT-CNS) is rare. The clinical symptoms and radiologic features of IMT-CNS are not specific; therefore, the diagnosis is predominately based on the histopathologic and immunohistochemical analysis of the specimen., Case Description: We herein present a case of a 21-year-old woman who complained of bilateral blurred vision for 15 days. Head magnetic resonance imaging demonstrated a round-shaped and irregular lesion located in the right frontal lobe. The boundary of the lesion was clear, and the lesion was homogeneously enhanced. Peripheral edema of the lesion was observed, and the mass effect was obvious. Supratentorial craniotomy tumor resection was performed. Histopathologic and immunohistochemical analysis revealed IMT, which had negative expression of anaplastic lymphoma kinase., Conclusions: Remission of her symptoms was observed, and no recurrence was recorded during a 6-month follow-up., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Although inflammatory myofibroblastic tumors (IMTs) are seen in the lower respiratory tract in the pediatric population, few cases occurring in the larynx have been reported in the literature. Treatment of choice is complete surgical excision because of risk of recurrence. We describe a case of pediatric subglottic IMT presenting with progressive hoarseness and symptoms of persistent reactive airway treated with potassium titanyl phosphate laser. We also enumerate the number of pediatric cases of IMT that occur in the larynx and subglottis compared with those which occur in the upper respiratory tract, specifically the trachea and bronchi. To the best of our knowledge, this is the first reported case of respiratory tract IMT excision using a potassium titanyl phosphate laser and the second reported case of a pediatric laryngeal IMT showing anaplastic lymphoma kinase-1 immunoreactivity., (Copyright © 2014 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)